CN104958743A - Traditional Chinese medicine composition for treating rheumatoid arthritis (RA) - Google Patents
Traditional Chinese medicine composition for treating rheumatoid arthritis (RA) Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines and in particular relates to a traditional Chinese medicine composition for treating rheumatoid arthritis (RA). The traditional Chinese medicine composition comprises the following traditional Chinese medicine compositions in parts by weight: 8-16 parts of morinda root, 8-16 parts of epimedium herb, 8-16 parts of common curculigo rhizome, 2-4 parts of dried human placenta, 2-4 parts of hairy antler, 8-16 parts of cassia twig, 8-16 parts of divaricate saposhnikovia root, 8-16 parts of incised notopterygium, 8-16 parts of doubleteeth pubescent angelica, 4-8 parts of prepared common monkshood daughter root, 8-16 parts of dried ginger, 4-8 parts of clove, 4-8 parts of common monkshood mother root, 2-4 parts of common threewingnut root, 8-16 parts of kadsura pepper stem, 8-16 parts of common clubmoss herb, 4-8 parts of scorpion, 8-16 parts of suberect spatholobus stem, 5-13 parts of cowherb seed and 4-8 parts of liquorice root. The inflammatory indicator level of RA can be obviously reduced, the functions of joints and the X-ray stage can be improved and the curative effects are definite by adopting the traditional Chinese medicine composition.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of rheumatoid arthritis.
Background technology
Rheumatoid arthritis (RA) is a kind of chronic, Progressive symmetric erythrokeratodermia, systematic autoimmune disease, with the persistence synovial membrane inflammation in joint, symmetry periphery for principal character.Its pathological characteristic is that synovial hyperplasia forms Xue Guan Medical, cause and osteoarticular invasion and attack are destroyed, if can not effective symptom management, the state of an illness can be caused to be progressive trend, because of the bone destruction of articular cartilage and bone, there is destruction of joint, tetanic and lopsided, and can amyotrophy be occurred in late period, be cause patient groups's disability and one of Etiological of disabling, the medical expense of great number causes huge financial burden also to family and society simultaneously.
Although western medical treatment RA onset is very fast, can controls and relief of symptoms, delay disease progression, the obvious toxic and side effects of normal appearance; Chinese medicine composition determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, adjustment body function, strengthens and while after treatment effect, side effect is less.
At present, need to find the Chinese medicine composition being exclusively used in treatment rheumatoid arthritis.
Summary of the invention
Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, a kind of Chinese medicine composition for the treatment of rheumatoid arthritis is provided, this Chinese medicine composition obviously can reduce the inflammatory parameters level of rheumatoid arthrosis, improves function of joint and x-ray by stages, determined curative effect.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for rheumatoid arthritis, be made up of the Chinese medicine composition of following weight portion:
Radix Morindae Officinalis 8-16 part, Herba Epimedii 8-16 part, Rhizoma Curculiginis 8-16 part, Placenta Hominis 2-4 part, Cornu Cervi Pantotrichum 2-4 part, Ramulus Cinnamomi 8-16 part, Radix Saposhnikoviae 8-16 part, Rhizoma Et Radix Notopterygii 8-16 part, Radix Angelicae Pubescentis 8-16 part, Radix Aconiti Lateralis Preparata 4-8 part, Rhizoma Zingiberis 8-16 part, Flos Caryophylli 4-8 part, Radix Aconiti 4-8 part, Radix Tripterygii Wilfordii 2-4 part, Caulis Piperis Kadsurae 8-16 part, Herba Lycopodii 8-16 part, Scorpio 4-8 part, Caulis Spatholobi 8-16 part, Semen Vaccariae 5-13 part, Radix Glycyrrhizae 4-8 part.
Preferably, the Chinese medicine composition of above-mentioned treatment rheumatoid arthritis, is made up of the Chinese medicine composition of following weight portion:
Radix Morindae Officinalis 10-14 part, Herba Epimedii 10-14 part, Rhizoma Curculiginis 10-14 part, Placenta Hominis 2.5-3.5 part, Cornu Cervi Pantotrichum 2.5-3.5 part, Ramulus Cinnamomi 10-14 part, Radix Saposhnikoviae 10-14 part, Rhizoma Et Radix Notopterygii 10-14 part, Radix Angelicae Pubescentis 10-14 part, Radix Aconiti Lateralis Preparata 5-7 part, Rhizoma Zingiberis 10-14 part, Flos Caryophylli 5-7 part, Radix Aconiti 5-7 part, Radix Tripterygii Wilfordii 2.5-3.5 part, Caulis Piperis Kadsurae 10-14 part, Herba Lycopodii 10-14 part, Scorpio 5-7 part, Caulis Spatholobi 10-14 part, Semen Vaccariae 7-11 part, Radix Glycyrrhizae 5-7 part.
Preferred, the Chinese medicine composition of above-mentioned treatment rheumatoid arthritis, is made up of the Chinese medicine composition of following weight portion:
Radix Morindae Officinalis 12 parts, Herba Epimedii 12 parts, Rhizoma Curculiginis 12 parts, Placenta Hominis 3 parts, 3 parts, Cornu Cervi Pantotrichum, Ramulus Cinnamomi 12 parts, Radix Saposhnikoviae 12 parts, Rhizoma Et Radix Notopterygii 12 parts, Radix Angelicae Pubescentis 12 parts, Radix Aconiti Lateralis Preparata 6 parts, Rhizoma Zingiberis 12 parts, Flos Caryophylli 6 parts, Radix Aconiti 6 parts, Radix Tripterygii Wilfordii 3 parts, Caulis Piperis Kadsurae 12 parts, Herba Lycopodii 12 parts, Scorpio 6 parts, Caulis Spatholobi 12, Semen Vaccariae 9 parts, 6 parts, Radix Glycyrrhizae.
The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.
The weight portion of said medicine, if in units of part, the normally consumption of 1 dose.
The indication of Chinese medicine composition of the present invention: be used for the treatment of rheumatoid arthritis.
The taboo item of Chinese medicine composition of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.
The Chinese medicine composition related in Chinese medicine composition prescription of the present invention all records in Chinese Pharmacopoeia 2010 editions.
The pathogenesis of RA is closely related with cold coagulation of suffering from a deficiency of the kidney.Because kidney is the viscus with functions of reproduction and development, the raw marrow of the main bone of store essential substances, the growth, growth, reparation etc. of bone all depend on the nourishing of essence in kidney, and kidney essense gas abundance just can make muscles and bones prosperous and powerful; Otherwise suffer from a deficiency of the kidney, bone is become homeless foster, exopathogen is had in opportunity and invades, blockage of main and collateral channels is numbness.As " in Principle and Prohibition for Medical profession air door " say " non-must to wet institute's numbness for wind and cold, it is thin that many natural endowmenies translate weakness of QI, and YIN-cold is condensed and do not understood in waist knee joint ", the cold coagulation that shows to suffer from a deficiency of the kidney is the major reason of morbidity.Reinforcing the kidney and supporting YANG, dispelling cold by warming the meridian, promoting blood circulation to remove obstruction in the collateral are its main rule for the treatment of.
Its prescription mechanism of Chinese medicine composition of the present invention is as follows:
Monarch drug: Radix Morindae Officinalis, Herba Epimedii, Rhizoma Curculiginis merit are with warming the kidney to invigorate YANG, bone and muscle strengthening, wind-damp dispelling.
Ministerial drug: Ramulus Cinnamomi, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis merit with dispersing wind-cold, exterior cold of dispelling; Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Flos Caryophylli merit with dispelling cold by warming the meridian, endogenous cold of dispelling.
Adjuvant drug: Placenta Hominis, Cornu Cervi Pantotrichum merit fill out marrow with the kidney invigorating and essence nourishing, it is foster to some extent that essence and blood fills then bone.Radix Aconiti, Radix Tripterygii Wilfordii, Caulis Piperis Kadsurae, Herba Lycopodii merit with wind-damp dispelling, removing obstruction in the collateral to relieve pain; Scorpio, Caulis Spatholobi, Semen Vaccariae merit are with promoting blood circulation to remove obstruction in the collateral.
Make medicine: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.
We's compatibility is reasonable, and all medicines share the effect of playing reinforcing the kidney and supporting YANG, dispelling cold by warming the meridian, promoting blood circulation to remove obstruction in the collateral altogether, and the rheumatoid arthritis that links closely is suffered from a deficiency of the kidney the pathogenesis of coagulated cold syndrome, obviously can reduce the inflammatory parameters level of rheumatoid arthrosis, improve function of joint and x-ray by stages, determined curative effect, is worthy to be popularized.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Treat a Chinese medicine composition for rheumatoid arthritis, each crude drug weight proportion is as follows:
Radix Morindae Officinalis 12g, Herba Epimedii 12g, Rhizoma Curculiginis 12g, Placenta Hominis 3g, Cornu Cervi Pantotrichum 3g, Ramulus Cinnamomi 12g, Radix Saposhnikoviae 12g, Rhizoma Et Radix Notopterygii 12g, Radix Angelicae Pubescentis 12g, Radix Aconiti Lateralis Preparata 6g, Rhizoma Zingiberis 12g, Flos Caryophylli 6g, Radix Aconiti 6g, Radix Tripterygii Wilfordii 3g, Caulis Piperis Kadsurae 12g, Herba Lycopodii 12g, Scorpio 6g, Caulis Spatholobi 12g, Semen Vaccariae 9g, Radix Glycyrrhizae 6g.
Embodiment 2
Treat a Chinese medicine composition for rheumatoid arthritis, each crude drug weight proportion is as follows:
Radix Morindae Officinalis 10g, Herba Epimedii 14g, Rhizoma Curculiginis 10g, Placenta Hominis 2.5g, Cornu Cervi Pantotrichum 3.5g, Ramulus Cinnamomi 14g, Radix Saposhnikoviae 10g, Rhizoma Et Radix Notopterygii 14g, Radix Angelicae Pubescentis 10g, Radix Aconiti Lateralis Preparata 5g, Rhizoma Zingiberis 14g, Flos Caryophylli 7g, Radix Aconiti 5g, Radix Tripterygii Wilfordii 2.5g, Caulis Piperis Kadsurae 10g, Herba Lycopodii 14g, Scorpio 7g, Caulis Spatholobi 10g, Semen Vaccariae 11g, Radix Glycyrrhizae 5g.
Embodiment 3
Treat a Chinese medicine composition for rheumatoid arthritis, each crude drug weight proportion is as follows:
Radix Morindae Officinalis 14g, Herba Epimedii 10g, Rhizoma Curculiginis 14g, Placenta Hominis 3.5g, Cornu Cervi Pantotrichum 2.5g, Ramulus Cinnamomi 10g, Radix Saposhnikoviae 14g, Rhizoma Et Radix Notopterygii 10g, Radix Angelicae Pubescentis 14g, Radix Aconiti Lateralis Preparata 7g, Rhizoma Zingiberis 10g, Flos Caryophylli 5g, Radix Aconiti 7g, Radix Tripterygii Wilfordii 3.5g, Caulis Piperis Kadsurae 14g, Herba Lycopodii 10g, Scorpio 5g, Caulis Spatholobi 14g, Semen Vaccariae 7g, Radix Glycyrrhizae 7g.
Embodiment 4
Treat a Chinese medicine composition for rheumatoid arthritis, each crude drug weight proportion is as follows:
Radix Morindae Officinalis 8g, Herba Epimedii 16g, Rhizoma Curculiginis 8g, Placenta Hominis 2g, Cornu Cervi Pantotrichum 4g, Ramulus Cinnamomi 16g, Radix Saposhnikoviae 8g, Rhizoma Et Radix Notopterygii 16g, Radix Angelicae Pubescentis 8g, Radix Aconiti Lateralis Preparata 4g, Rhizoma Zingiberis 16g, Flos Caryophylli 8g, Radix Aconiti 4g, Radix Tripterygii Wilfordii 4g, Caulis Piperis Kadsurae 16g, Herba Lycopodii 8g, Scorpio 8g, Caulis Spatholobi 16g, Semen Vaccariae 5g, Radix Glycyrrhizae 4g.
Embodiment 5
Treat a Chinese medicine composition for rheumatoid arthritis, each crude drug weight proportion is as follows:
Radix Morindae Officinalis 16g, Herba Epimedii 8g, Rhizoma Curculiginis 16g, Placenta Hominis 4g, Cornu Cervi Pantotrichum 2g, Ramulus Cinnamomi 8g, Radix Saposhnikoviae 16g, Rhizoma Et Radix Notopterygii 8g, Radix Angelicae Pubescentis 16g, Radix Aconiti Lateralis Preparata 8g, Rhizoma Zingiberis 8g, Flos Caryophylli 4g, Radix Aconiti 8g, Radix Tripterygii Wilfordii 2g, Caulis Piperis Kadsurae 8g, Herba Lycopodii 16g, Scorpio 4g, Caulis Spatholobi 8g, Semen Vaccariae 13g, Radix Glycyrrhizae 8g.
Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:
1. data and method
1.1 object of study
Choose 150 routine rheumatoid arthritis to suffer from a deficiency of the kidney coagulated cold syndrome patient.
1.2 Western medicine diagnose standards
Meet the standard of Americanism damp disease academic year revision:
(1) refuse to budge morning continuous 1 hour (>=6 weeks).
(2) more than 3 or 3 arthroncuss (>=6 weeks) are had.
(3) wrist, the palm refer to and proximal interphalangeal joint swollen (>=6 weeks).
(4) symmetry swollen joint (>=6 weeks).
(5) subcutaneous nodule is had.
(6) hands line changes (having the narrow of osteoporosis and joint space at least).
(7) rheumatoid factor positive (titre >1:32).
Possessing above more than 4 or 4 persons all diagnosable is rheumatoid arthritis.
1.3 TCM syndrome diagnostic criteria
Meet arthromyodynia to suffer from a deficiency of the kidney the CM syndrome differentiation criterion of coagulated cold syndrome: disease is seen: arthralgia is the spleen-distension, and morning is stiff, and movable unfavorable, fear of cold is afraid of cold, and refreshing tired lazyness is moved, and aching pain in waist and back, pitching is unfavorable, and cold weather increases the weight of, and light red tongue is fat, answers whiten, deep-thready pulse.
1.4 inclusive criteria
1. meet doctor trained in Western medicine Diagnosis of Rheumatoid Arthritis standard, and meet the patient of the empty coagulated cold syndrome CM syndrome differentiation criterion of Kidney Theory in TCM simultaneously;
2. the age is between 18-65 years old, male or female;
3. informed consent, volunteers tested.
4. function of joint 1-3 level.
5. x-ray I-III phase by stages.
1.5 exclusion standard
(1) age year below or year more than, gestation and the female patient of age of sucking;
(2) severe primary disease, the psychotics such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system is associated with;
(3) serious stomach or duodenal ulcer or rotten to the corn person is associated with;
(4) patient of severe joint deformity, afunction;
(5) other Patients with Rheumatic Diseases are associated with;
(6) the dialectical claimer of coagulated cold syndrome of suffering from a deficiency of the kidney is not met;
(7) arthrotrauma history person;
(8) to the not resistance to receptor of this medicine;
(9) function of joint 4 grades, the patient of x-ray IV phase;
1.6 Therapeutic Method
Treatment group gives traditional Chinese medicine composition for treating of the present invention, and prescription is as follows: Radix Morindae Officinalis 12g, Herba Epimedii 12g, Rhizoma Curculiginis 12g, Placenta Hominis 3g(grind into powder and take after mixing it with water), Cornu Cervi Pantotrichum 3g(grinds into powder and takes after mixing it with water), Ramulus Cinnamomi 12g, Radix Saposhnikoviae 12g, Rhizoma Et Radix Notopterygii 12g, Radix Angelicae Pubescentis 12g, Radix Aconiti Lateralis Preparata 6g, Rhizoma Zingiberis 12g, Flos Caryophylli 6g, Radix Aconiti 6g, Radix Tripterygii Wilfordii 3g, Caulis Piperis Kadsurae 12g, Herba Lycopodii 12g, Scorpio 6g, Caulis Spatholobi 12, Semen Vaccariae 9g, Radix Glycyrrhizae 6g.Be decocted in water for oral dose, day potion, sooner or later sub-service was a course for the treatment of with 2 weeks.
1.7 observation index
1. TCM syndrome integration;
2. main physical signs arthroncus degree, articular pain degree, grip;
3. inflammatory parameters: ESR, RF, CRP, x-ray are by stages etc.;
5. respectively rheumatoid arthritis clinical symptoms and sign classification and scoring, Chinese medicine syndrome integral are evaluated before and after treatment.
1.8 traditional Chinese medical science sign curative effect determinate standards
1. clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%
2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%
3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%
4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces <30%.
Computing formula: nimodipine method: integration x100% before (before treatment the rear integration of integration-treatment)/treatment.
1.9 statistical analysis technique
Using statistics software carries out analytic statistics analysis.Enumeration data adopts X2 inspection, and measurement data adopts t inspection, with P<0.05, ranked data Bian rank test, represents that difference has statistical significance.
2. result
Inflammatory parameters change before and after 2.1 treatments
Front and back inflammatory parameters change treated by table 1
Time | ESR | RF | CRP |
Before treatment | 52.14±13.43 | 612.21±102.45 | 142.92±33.09 |
After treatment | 10.21 ±2.92 | 87.23±23.26 | 28.28±6.12 |
After treatment, ESR, RF, CRP level is obviously improved before all comparatively treating, and difference has statistical significance (P<0.05); In table 1.
Before and after 2.2 treatments, function of joint classification and x-ray compare by stages
Treatment posterior joint functional classification and x-ray be all comparatively front obviously improvement for the treatment of by stages, and difference has statistical significance (P<0.05), in table 2.
2.3 TCM syndrome curative effects
150 routine patients, recovery from illness 79 example, effective 52 examples, effective 16 examples, invalid 3 examples, cure rate 52.7%, total obvious effective rate 87.3%, total effective rate 98.0%.
Claims (3)
1. treat a Chinese medicine composition for rheumatoid arthritis, be made up of the Chinese medicine composition of following weight portion:
Radix Morindae Officinalis 8-16 part, Herba Epimedii 8-16 part, Rhizoma Curculiginis 8-16 part, Placenta Hominis 2-4 part, Cornu Cervi Pantotrichum 2-4 part, Ramulus Cinnamomi 8-16 part, Radix Saposhnikoviae 8-16 part, Rhizoma Et Radix Notopterygii 8-16 part, Radix Angelicae Pubescentis 8-16 part, Radix Aconiti Lateralis Preparata 4-8 part, Rhizoma Zingiberis 8-16 part, Flos Caryophylli 4-8 part, Radix Aconiti 4-8 part, Radix Tripterygii Wilfordii 2-4 part, Caulis Piperis Kadsurae 8-16 part, Herba Lycopodii 8-16 part, Scorpio 4-8 part, Caulis Spatholobi 8-16 part, Semen Vaccariae 5-13 part, Radix Glycyrrhizae 4-8 part.
2. the Chinese medicine composition for the treatment of rheumatoid arthritis according to claim 1, is characterized in that, is made up of the Chinese medicine composition of following weight portion:
Radix Morindae Officinalis 10-14 part, Herba Epimedii 10-14 part, Rhizoma Curculiginis 10-14 part, Placenta Hominis 2.5-3.5 part, Cornu Cervi Pantotrichum 2.5-3.5 part, Ramulus Cinnamomi 10-14 part, Radix Saposhnikoviae 10-14 part, Rhizoma Et Radix Notopterygii 10-14 part, Radix Angelicae Pubescentis 10-14 part, Radix Aconiti Lateralis Preparata 5-7 part, Rhizoma Zingiberis 10-14 part, Flos Caryophylli 5-7 part, Radix Aconiti 5-7 part, Radix Tripterygii Wilfordii 2.5-3.5 part, Caulis Piperis Kadsurae 10-14 part, Herba Lycopodii 10-14 part, Scorpio 5-7 part, Caulis Spatholobi 10-14 part, Semen Vaccariae 7-11 part, Radix Glycyrrhizae 5-7 part.
3. the Chinese medicine composition for the treatment of rheumatoid arthritis according to claim 3, is characterized in that, is made up of the Chinese medicine composition of following weight portion:
Radix Morindae Officinalis 12 parts, Herba Epimedii 12 parts, Rhizoma Curculiginis 12 parts, Placenta Hominis 3 parts, 3 parts, Cornu Cervi Pantotrichum, Ramulus Cinnamomi 12 parts, Radix Saposhnikoviae 12 parts, Rhizoma Et Radix Notopterygii 12 parts, Radix Angelicae Pubescentis 12 parts, Radix Aconiti Lateralis Preparata 6 parts, Rhizoma Zingiberis 12 parts, Flos Caryophylli 6 parts, Radix Aconiti 6 parts, Radix Tripterygii Wilfordii 3 parts, Caulis Piperis Kadsurae 12 parts, Herba Lycopodii 12 parts, Scorpio 6 parts, Caulis Spatholobi 12, Semen Vaccariae 9 parts, 6 parts, Radix Glycyrrhizae.
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KR20110109607A (en) * | 2010-03-31 | 2011-10-06 | 이윤식 | Composition of herb medicine for reliefing and curing lumbar disc pain |
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