CN104940800A - Traditional Chinese medicine composition for treating pancreatic cancer and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating pancreatic cancer and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating a pancreatic cancer and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-25 parts of thunder god vine, 15-20 parts of trametes robinioplila, 15-20 parts of cyathula prostrate, 15-20 parts of dandelion, 5-10 parts of mother chrysanthemum flower, 3-10 parts of peach peel, 3-10 parts of cucumber peel, 3-10 parts of bitter gourd peel, 3-10 parts of peach kernel, 5-10 parts of lucid ganoderma, 5-10 parts of angelica sinensis, 5-10 parts of salviae miltiorrhizae, 5-10 parts of radix curcumae longae, 3-5 parts of hawthorn and 5-10 parts of liquorice. The preparation method comprises the following steps: weighing raw materials, and putting into a container; and adding purified water, a bifidobacterium strain and a sweetening agent, sealing, putting the container into an environment at 18-25 DEG C, standing for 40-50 days, and taking the traditional Chinese medicine composition. The traditional Chinese medicine composition is significant in curative effect, and small in toxic or side effect; through a bio-fermentation technology, active components of the traditional Chinese medicines are prevented from being damaged to the maximal extent; the medicine effect is improved; and meanwhile, the toxic or side effects of triptolide are reduced.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition being used for the treatment of cancer of pancreas and preparation method thereof.
Background technology
Cancer of pancreas is common malignant tumor, grade malignancy is higher, development is fast, poor prognosis, although medical skill has had large increase over nearly 20 years, but in Diagnosis and Treat cancer of pancreas, still there is a lot of problem, early stage diagnosis rate is not high, and operative mortality is still higher, and cure rate is very low, cancer of pancreas is multiple is born in middle-aged and elderly people, and developed country's sickness rate is higher than developing country.Along with the change of China's growth in the living standard and dietary structure, the sickness rate of cancer of pancreas presents the trend of rising and has the tendency of rejuvenation in recent years.
Triptolide is the main active of Chinese herb triperygium wilfordii, derives from the root of Chinese herb triperygium wilfordii.In recent years, because triptolide shows multiple biological activity, as antiinflammatory, immunosuppressant, anti-cyst, especially active anticancer, cause great concern, show according to latest research, triptolide can anti-cancer of pancreas, but Radix Tripterygii Wilfordii is very toxic, how to effectively reduce toxin, be the key of Radix Tripterygii Wilfordii extensive use.
Modern sweat research shows, the multiple biotransformation capacity such as microorganism species has oxidation, esterification, methylates, hydroxylating, reducing.Chinese herbal medicine is after fermentation, its effective ingredient fully can be separated, be extracted, it is made to have more biological activity, and to make in fermentation liquid, containing a large amount of organized enzyme, to be absorbed rapidly by body tissue cell after taking, reach and get rid of illness, be healthy and strong, strengthen immunoregulatory function, play the drug effect of natural Chinese medicinal herb better, noxious substance in Chinese medicine also can decompose by the decomposition of microorganism, thus reduces the toxic and side effects of medicine, but is still in the stage of fumbling to Chinese medicine fermentation technique both at home and abroad at present.
Summary of the invention
A kind of Chinese medicine composition for the treatment of cancer of pancreas, it is characterized in that the crude drug comprising following parts by weight: Radix Tripterygii Wilfordii 20 ~ 25 parts, Auricularia Sophorae 15 ~ 20 parts, Herba Cyathulae Prostratae 15 ~ 20 parts, Herba Taraxaci 15 ~ 20 parts, Flos Chrysanthemi Indici 5 ~ 10 parts, Fructus Persicae skin 3 ~ 10 parts, peel of Fructus Cucumidis sativi 3 ~ 10 parts, Fructus Momordicae charantiae skin 3 ~ 10 parts, 3 ~ 10 parts, Semen Persicae, Ganoderma 5 ~ 10 parts, Radix Angelicae Sinensis 5 ~ 10 parts, Radix Salviae Miltiorrhizae 5 ~ 10 parts, 5 ~ 10 parts, Rhizoma Curcumae Longae, Fructus Crataegi 3 ~ 5 parts and 5 ~ 10 parts, Radix Glycyrrhizae.
Preferably, described a kind for the treatment of in the raw material components of the Chinese medicine composition of cancer of pancreas also comprises bifidobacterium strain and sweeting agent, and the weight portion that described bifidobacterium strain and sweeting agent add is respectively 0.02 ~ 0.05 part and 9 ~ 15 parts.
Preferably, the parts by weight of each crude drug are: Radix Tripterygii Wilfordii 23 parts, Auricularia Sophorae 18 parts, Herba Cyathulae Prostratae 15 parts, Herba Taraxaci 16 parts, Flos Chrysanthemi Indici 7 parts, Fructus Persicae skin 7 parts, peel of Fructus Cucumidis sativi 7 parts, Fructus Momordicae charantiae skin 7 parts, 7 parts, Semen Persicae, Ganoderma 7 parts, Radix Angelicae Sinensis 8 parts, Radix Salviae Miltiorrhizae 8 parts, 9 parts, Rhizoma Curcumae Longae, Fructus Crataegi 3 parts and 8 parts, Radix Glycyrrhizae;
Preferably, the bacillus bifidus added and the weight portion of sweeting agent are respectively 0.03 part and 12 parts.
Preferably, described sweeting agent is brown sugar or Mel.
Described a kind of Chinese medicine composition for the treatment of cancer of pancreas, it is characterized in that its preparation method is: by proportioning weighting raw materials, put into container, add pure water, amount of water is 52 ~ 62 times of crude drug quality, adds bacillus bifidus simultaneously, then seal, container is placed in the environment of 18 ~ 25 DEG C, shelves 40 ~ 50 days, can take.
Preferably, the viable count that the described bacillus bifidus of the bacillus bifidus every gram added in crude drug contains is 12 ~ 1,700,000,000.
In pharmaceutical composition of the present invention:
Radix Tripterygii Wilfordii: bitter in the mouth, pungent, cool in nature, greatly poison.Return liver, kidney channel.Effect expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, reducing swelling and alleviating pain, removing toxic substances parasite killing.For damp and hot tuberosity, the long-pending poison of carcinoma, treat lepra reaction, rheumatoid arthritis with it clinically.
Auricularia Sophorae: bitter in the mouth, pungent is flat, nontoxic.Return liver, spleen, large intestine channel.Hemostasis, dysentery relieving, anticancer, control hemorrhoid, have blood in stool, proctoptosis, metrorrhagia.
Herba Cyathulae Prostratae: pained, micro-cool.Heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis.Cure mainly carbuncle pyogenic infections from tumour or sore; Venom; Traumatic injury congestive edema.
Herba Taraxaci: sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Cure mainly upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder assists inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.
Flos Chrysanthemi Indici: pungent, bitter.Return lung, Liver Channel.Heat-clearing and toxic substances removing, liver heat removing and eyesight improving, dispelling wind and heat pathogens.Cure mainly furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Hypertension.
Fructus Persicae skin: sweet in the mouth, acid, warm in nature.There are intestine moistening of promoting the production of body fluid, promoting blood circulation to remove stagnancy, the effect of rich flesh skin Caring.
Peel of Fructus Cucumidis sativi: containing chlorogenic acid and caffeic acid, can play the effect of anti-inflammation and stimulation leukocytes phagocytic.
Fructus Momordicae charantiae skin: cold in nature, bitter in the mouth.Enter the heart, spleen, stomach warp, clearing away summer-heat washs heat, and improving eyesight is detoxified.
Semen Persicae: bitter but sweet flavor and property are put down, and can enter the heart, liver, large intestine, blood circulation promoting and blood stasis dispelling effect is very wide, availablely controls the various worn-out disease of stagnation of blood stasis.
Ganoderma: sweet in the mouth, micro-hardship, property is put down.Energy benefiting qi and nourishing blood, tranquilizing by nourishing the heart, cough-relieving is flat to be coughed.There is anti-aging effects, the immunologic function of energy enhancing body; There is sedation; Eliminate the phlegm, cough-relieving, antiasthmatic effect; There is cardiotonic, can myocardial flow be increased, increase coronary flow, reduce heart stock oxygen consumption, strengthen hypoxia-bearing capability; Can blood fat be reduced, regulate blood pressure, the liver protecting, leukocyte increasing; There is certain antitumor action.
Rhizoma Curcumae Longae: pungent, bitter, temperature.Return spleen, Liver Channel.Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.Enter the heart, Liver Channel.Promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spit blood, mastitis, carbuncle.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Fructus Crataegi: acid is sweet, tepor.Enter spleen, stomach, Liver Channel.Help digestion long-pending, dissipating blood stasis blood, expelling tenia, controls meat and amasss, lump in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia after-pains in puerperal, lochiorrhea, and children's's breast food is stagnated.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.
Triptolide is rich in Radix Tripterygii Wilfordii in medicine of the present invention, GRP78 can be suppressed, finally cause the death of pancreatic cancer cell, GRP78 is that a kind of Cell protection avoids dead protein, compared with normal organ, this albumen is abundanter in cancerous cell and tissue, be considered in the survival of help pancreatic cancer cell and play an important role in growing up, Auricularia Sophorae, Herba Cyathulae Prostratae and Herba Taraxaci can strengthening the body resistance, to invigorate blood circulation Xiao Disorder blood stasis dispelling, eliminating carbuncle eliminating stagnation, the common Shi Re Bing Pian of most Pancreas cancer patients clinically, blood stasis, the stagnation of QI, three hands over the symptom of resistance, it is the pathology key of cancer of pancreas that the poison stasis of blood is tied mutually, we are with Radix Tripterygii Wilfordii, Auricularia Sophorae, Herba Cyathulae Prostratae and Herba Taraxaci four Chinese medicine are monarch drug, effect that Flos Chrysanthemi Indici, Fructus Persicae skin, peel of Fructus Cucumidis sativi, Fructus Momordicae charantiae skin, the above five kinds of Chinese medicine of Semen Persicae have anti-inflammation, blood circulation promoting and blood stasis dispelling and heat-clearing and toxic substances removing can assist the toxicity alleviating Radix Tripterygii Wilfordii, and make property of medicine temperature, cold collocation, the component of medicine-food two-purpose is adopted to promote absorption of human body, alleviating Liver and kidney burden, is ministerial drug, Ganoderma, Rhizoma Curcumae Longae, Radix Salviae Miltiorrhizae and Fructus Crataegi have blood circulation regulating, dissipating blood stasis blood, nourish strong effect, are used for taking good care of health, and improve immunity, treating both the principal and secondary aspects of a disease is adjuvant drug, Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, and middle emergency can coordinating the actions of various ingredients in a prescription, for making medicine.
Bacillus bifidus is the profitable strain in humans and animals intestinal, has substantial connection with the health of body.Under health status, bacillus bifidus can play biological barrier, provides nutrition, improve the nutrition health-care functions such as immunity.Take in bacillus bifidus and can improve body antibody horizontal, the activate the phagocytic capacity of activating macrophage, and the anti-infection ability improving body, suppress and kill tumor cell.
Technique effect of the present invention is as follows: the present invention effectively make use of the inhibitory action of triptolide to pancreatic cancer cell, by introducing bifidobacterium strain, make itself and Chinese medicine compound synergic fermentation, Secondary Metabolites of Microorganisms and middle the effective elements of the medicine generation synergism, thus improve the ratio of active ingredient of Chinese herbs in compound formulation and tire, microorganism can extracellular proteinase in metabolic process, cellulase, hemicellulase, pectase, tens kinds of exoenzymes such as amylase enter culture medium, what these enzymes had can by ingredient decomposition and inversion, make the cellulose in cell wall and intercellular substance, the mass degradations such as hemicellulose, make cell rupture, intercellular substance increases, reduce cell wall, intercellular substance transmits barrier, to effective ingredient from born of the same parents to the drag reduction of born of the same parents' external diffusion, can promote that the absorption of effective ingredient improves, Radix Tripterygii Wilfordii is a kind of new drug resource that China develops in recent years, there is immunosuppressant, antiinflammatory, antitumor isoreactivity, but because nephrotoxicity is large, its clinical practice is restricted always, adopt microbiological transformation technology to carry out structural modification to triptolide and Tripterygium wilfordii lactone ketone, the derivant of high-efficiency low-toxicity can be obtained, in addition, the present invention is theoretical according to the marrow of Traditional Chinese Medicine, for Pancreas cancer patients Shi Re Bing Pian, blood stasis, the stagnation of QI, three hands over the symptom of resistance, adopts the Chinese medicinal components of multiple medicine-food two-purpose, gold compatibility, alleviate Liver and kidney burden, to killing off tumor cells and to reduce tumor effect splendid.
Detailed description of the invention
The health promoting beverage of the Chinese medicine composition for the treatment of cancer of pancreas of the present invention is described in detail below in conjunction with specific embodiment:
The raw material components table of table 1 embodiment 1 ~ 4
Preparation method is as follows:
Each component raw material medicine of embodiment 1,2,3 and 4 is taken respectively by the proportioning of table 1, Homogeneous phase mixing, in whole placing container, add pure water, add bifidobacterium strain and sweeting agent respectively by the proportioning of table 1 simultaneously, then seal, container is placed in respectively in the isoperibol of 18 DEG C, 21 DEG C, 22 DEG C, 25 DEG C, shelve 50,45,46,40 days respectively, can take; When taking, every day takes twice, each 80 ~ 100mL.
Model case is as follows:
1, patient Wang, man, 63 years old, finds cancer of pancreas 2 months, take the embodiment of the present invention 1 latter 3 months, the remission of the glutted discomfort of epigastrium, pain, during chemotherapy and drug administration, patient obviously declines, after symptom disappears completely without obvious toxicity tumor markers, continue to take 2 months, have regular physical checkups, stable disease, gets nowhere.
2, patient shuts out certain, female, 54 years old, and find that cancer of pancreas is after 4 months, after taking the embodiment of the present invention 4, jaundice changes latent jaundice into by clinical jaundice, and nausea and vomiting, symptom of diarrhea are alleviated, and after end of chemotherapy, continue to take 3 months, stable disease.
3, patient Lv, man, 69 years old, find that cancer of pancreas is after 1 month, after taking the embodiment of the present invention 2, fever on and off symptom is effectively controlled, appetite strengthens, and food-intake increases, after combined with chemotherapy takes 3 months, cancerous protuberance atrophy, continue to take medicine 4 months, excision is performed a surgical operation excision, after taking medicine 1 month, cut out, do not recur so far.
Curative effect and toxicity assessment:
Randomly draw medical Pancreas cancer patients 80 example, 49 ~ 78 years old age, male 46 people, female 44 people, carries out curative effect and toxicity assessment;
1,80 routine Pancreas cancer patients take Chinese medicine composition of the present invention, and curative effect is: cure 5 examples, and take a turn for the better 63 examples, invalid 12 examples, effective percentage 85%.
2, toxicity assessment: continue with drug administration before medication respectively to do a health check-up afterwards, a health check-up project in month: (1) is health check-up project generally: temperature pulse respiration.(2) blood, urine, stool routine examination inspection, before and after treatment, each work once.(3) liver function AST, ALT; Renal function BUN, CR and blood glucose; Cardiac function CPK, LDH, EKG; Coagulation function and platelet.
To toxicity assessment classification, standard is as follows:
0 grade: avirulence Symptoms; L level: mild toxicity Symptoms; 2 grades: moderate signs of toxicity shows; 3 grades: serious toxicity Symptoms; 4 grades: threat to life signs of toxicity shows;
Draw according to physical examination result analysis, in 80 routine Pancreas cancer patients, 0 grade of 74 people, 1 grade of 5 people, 3 grade of 1 people, 4 grade of 0 people.
As can be seen from curative effect and toxicity assessment, Chinese medicine composition of the present invention can control the pathological changes process of cancer of pancreas effectively, and toxic and side effects is less.
Experimental example 1
Experiment grouping: by 100 mices, 4 ~ 6 weeks age, body weight 25 ~ 30g, male and female regardless of, be divided into pancreatic cancer models group 80 and matched group 20 at random, conventionally take food and raising of freely drinking water.
Configuration carcinogen: get 100mg DMBA and add in 1ml Tween 80, is placed in 60 DEG C of water baths and makes it to dissolve; Add normal saline and shake 12h through agitator, be diluted to the DMBA suspension solution that final concentration is 10mg/ml.
Experiment:
(1) pancreatic cancer models group 80 mice pre-operative anxiety 24h, can't help water.2% pentobarbital sodium (1.5ml/kg body weight) intraperitoneal injects anesthesia, often organizes mice and all enters abdomen through Median incision on upper abdomen 1.5cm.Pancreatic cancer models group, after exposure pancreas, is inserted DMBA suspension (100mg/100g body weight) in pancreatic tail with 1ml injector to inject (dark 2mm), is raised in conventional environment.Mice mental status, body weight and with or without ascites etc. is observed at any time during the 3-5 month.Matched group is carried out at pancreatic tail is placed in equivalent normal saline with 1ml injector to inject (dark 2mm).
(2) after postoperative 48h, model group is divided into 4 groups at random, often organizes 20, is respectively model group 1, model group 2, model group 3 and model group 4; Model group 1, model group 2 and model group 3 take the medicine of embodiment 1,2 and 3 respectively, every day gavage 2ml/, one day three times; Model group 4, according to the crude drug proportioning of embodiment 2, does not add bacillus bifidus and ferments, and pulverized by crude drug, sieve 100 orders, and after mix homogeneously, put into marmite and decoct 1.5 hours, taking liquid is taken, every day gavage 2ml/, one day three times; Model group 5 is normally taken food, every day same time gavage equivalent sterile saline; After postoperative 5 months, all white mice are cut open the belly observation, result as table 2,
Table 2 modelling to be cut open the belly observed result to 100 white mice after postoperative 5 months
DMBA is a kind of stronger carcinogen, very strong effect is formed to what bring out animal tumor, as can be seen from Table 2, crude drug of the present invention can the expression of effective anticancer, and Chinese medicinal components evident in efficacy higher than the curative effect directly decocting and drink of not fermenting after fermentation, because medical material effective ingredient is present in endochylema more, plant cell wall is by cellulose, hemicellulose, pectic substance, the compact texture that the materials such as lignin are formed, in traditional Chinese medicine extyaction process, when the effective ingredient in endochylema spreads to Extraction medium, the dual resistance of cell wall and intercellular substance must be overcome, effective ingredient is leached be obstructed.Microorganism can utilize the composition in Chinese medicine to carry out dividing, grow, breed and metabolism for nutrition, in metabolic process, tens kinds of exoenzymes such as extracellular proteinase, cellulase, hemicellulase, pectase, amylase enter culture medium, make cell rupture, intercellular substance increases, reduce the mass transfer such as cell wall, intercellular substance barrier to effective ingredient from born of the same parents to the resistance to mass tranfer of Extraction medium diffusion, thus raising drug effect, play a multiplier role.
Experimental example 2
Human pancreas cancer cell strain is put into the RPMI-1640 complete medium containing 10%, be placed in 37 DEG C, 5%CO
2in incubator, every 2d changes liquid 1 time, 2 ~ 3d, the trypsinization of 0.25%, and one passes 3 Secondary Culture.
(1) until at the bottom of cell is covered with bottle time, single cell suspension is collected, every only 5 × 10
6tumor cell, 0.2ml, is injected in 100 naked white mice axillary fossa places subcutaneous, sets up tumor model.
(2) postoperative, by 100 naked white mice, 4 ~ 6 week age, body weight 25 ~ 30g, male and female regardless of, be divided into 5 groups at random, be respectively treatment group 1, treatment group 2, treatment group 3, treatment group 4 and matched group, treatment group 1, treatment group 2, treatment group 3 take the Chinese medicine composition of embodiment 2,3,4 respectively, every gavage 3ml/, one day three times; Treatment group 4 by the crude drug proportioning of embodiment 3, but does not add bacillus bifidus and carries out by fermentation, and pulverized by crude drug, sieve 100 orders, and after mix homogeneously, put into marmite and decoct 1.5 hours, taking liquid is taken, every day gavage 3ml/, one day three times; Matched group is normally taken food, every day same time gavage equivalent sterile saline;
(3) use weekly vernier caliper measurement tumor size, by formula: gross tumor volume=(π/6) × length × wide × height, calculate tumor size, shown in result table 3,
The gross tumor volume of the naked white mice of table 3 is along with the growth pattern of the prolongation of inoculation time
As can be seen from Table 3, the growth of the present invention to pancreatic tumour has good inhibitory action, and crude drug by fermentation after, enhancing evident in efficacy.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (7)
1. treat the Chinese medicine composition of cancer of pancreas for one kind, it is characterized in that the crude drug comprising following parts by weight: Radix Tripterygii Wilfordii 20 ~ 25 parts, Auricularia Sophorae 15 ~ 20 parts, Herba Cyathulae Prostratae 15 ~ 20 parts, Herba Taraxaci 15 ~ 20 parts, Flos Chrysanthemi Indici 5 ~ 10 parts, Fructus Persicae skin 3 ~ 10 parts, peel of Fructus Cucumidis sativi 3 ~ 10 parts, Fructus Momordicae charantiae skin 3 ~ 10 parts, 3 ~ 10 parts, Semen Persicae, Ganoderma 5 ~ 10 parts, Radix Angelicae Sinensis 5 ~ 10 parts, Radix Salviae Miltiorrhizae 5 ~ 10 parts, 5 ~ 10 parts, Rhizoma Curcumae Longae, Fructus Crataegi 3 ~ 5 parts and 5 ~ 10 parts, Radix Glycyrrhizae.
2. a kind of Chinese medicine composition for the treatment of cancer of pancreas according to right 1, it is characterized in that the parts by weight of each crude drug are: Radix Tripterygii Wilfordii 23 parts, Auricularia Sophorae 18 parts, Herba Cyathulae Prostratae 15 parts, Herba Taraxaci 16 parts, Flos Chrysanthemi Indici 7 parts, Fructus Persicae skin 7 parts, peel of Fructus Cucumidis sativi 7 parts, Fructus Momordicae charantiae skin 7 parts, 7 parts, Semen Persicae, Ganoderma 7 parts, Radix Angelicae Sinensis 8 parts, Radix Salviae Miltiorrhizae 8 parts, 9 parts, Rhizoma Curcumae Longae, Fructus Crataegi 3 parts and 8 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine composition for the treatment of cancer of pancreas according to claim 1 and 2, characterized by further comprising bifidobacterium strain and sweeting agent, and the weight portion that described bifidobacterium strain and sweeting agent add is respectively 0.02 ~ 0.05 part and 9 ~ 15 parts.
4. a kind of Chinese medicine composition for the treatment of cancer of pancreas according to claim 3, is characterized in that the viable count that every gram of described bacillus bifidus contains is 12 ~ 1,700,000,000.
5. a kind of Chinese medicine composition for the treatment of cancer of pancreas according to claim 3, is characterized in that, the bacillus bifidus added and the weight portion of sweeting agent are respectively 0.03 part and 12 parts.
6., according to the arbitrary described a kind of Chinese medicine composition for the treatment of cancer of pancreas of claim 3 or 5, it is characterized in that described sweeting agent is brown sugar or Mel.
7. a kind of Chinese medicine composition for the treatment of cancer of pancreas according to claim 1, is characterized in that its preparation method comprises the steps:
By proportioning weighting raw materials, put into container, add pure water, amount of water is 52 ~ 62 times of the weight of raw material components, adds bacillus bifidus and sweeting agent simultaneously, then seals, and is placed in by container in the environment of 18 ~ 25 DEG C, shelves 40 ~ 50 days, to obtain final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102805840A (en) * | 2012-08-21 | 2012-12-05 | 亳州康复肿瘤药物研究所 | Complex anti-tumor traditional Chinese medicine preparation |
| CN104095225A (en) * | 2014-06-11 | 2014-10-15 | 胡安然 | Microecologic special diet for patients with pancreatic cancer |
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- 2015-05-22 CN CN201510265326.1A patent/CN104940800A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805840A (en) * | 2012-08-21 | 2012-12-05 | 亳州康复肿瘤药物研究所 | Complex anti-tumor traditional Chinese medicine preparation |
| CN104095225A (en) * | 2014-06-11 | 2014-10-15 | 胡安然 | Microecologic special diet for patients with pancreatic cancer |
Non-Patent Citations (1)
| Title |
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| 魏长志等主编: "《抗肿瘤中药集锦》", 31 August 2010, 中医古籍出版社 * |
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Application publication date: 20150930 |