CN104922192A - Traditional Chinese medicine for treating fracture and preparation method thereof - Google Patents
Traditional Chinese medicine for treating fracture and preparation method thereof Download PDFInfo
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Abstract
A traditional Chinese medicine for treating fracture is prepared from a monarch drug, a ministerial drug, an adjuvant and an envoy drug, and is characterized by comprising 200 g of the monarch drug which is radix dipsaci, 200 g of the ministerial drug which is rhizoma drynariae, 1000 g of the adjuvant which is cucumis satiuus, and 200 g of the envoy drug which is calcined concha ostreae. The traditional Chinese medicine has the effects of reinforcement and elimination in combination, nourishing blood, promoting blood circulation, activating blood to remove blood stasis, dispersing blood stasis, promoting fresh blood production, promoting reunion of fractured bones, relieving swelling and pain, and avoiding acute and subacute toxicity, has the efficacies of nourishing liver and kidney, regulating qi and blood, promoting reunion of fractured bones, and treating fracture, can promote granulation neogenesis and callus growth, accelerate fracture healing, rejoin fractured bones, and alleviate pains.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of fracture and preparation method thereof.
Background technology
When the integrity of bone or seriality are interrupted, be referred to as fracture.The fracture that violence causes, is referred to as traumatic fracture, and the broken ends of fractured bone mostly is cross-section or comminuted, the fracture that indirect violence causes, and comprises and passes on violence, torsion violence etc., how to cause oblique or spiral type section at the weak place of sclerotin.Easily there is fatigue fracture in persistence strain.In addition, osteoporosis also can bring out fracture, generally be more common in middle-aged and elderly people, women is multiple be born in more than 50 years old, male is multiple is born in more than threescore, and with age with the increasing the weight of of osteoporosis, fracture can successively repeatedly or multiple position occur, traumatic fracture is general irrelevant with the age, can occur in any age bracket, the between twenty and fifty chance mainly having born social labor is more.At present, the medicament categories of commercially available treatment fracture is a lot, and such as: spray formula medicine for external use, cream formula, powder type application compress, various dosage form oral medicine, local injection injection drug etc., should say respective feature and curative effect.Hospital is reset to master to fracture patient great majority with operative treatment, postoperatively still needs interior extenal fixation, the dislocation of the control broken ends of fractured bone or deformity.Pole has a few patients to adopt manual reduction and Gypsum Fibrosum extenal fixation, and the later stage all needs by transfusion, antiinflammatory of having an injection, the treatment of oral activating blood and removing stasis drug.Clinical present treatment fracture is divided into " three phases ", according to development after damage, is generally divided into morning, intermediary and later stages.
One, damaging early stage treatment, i.e., in the time in 1-2 weeks, is main mainly with blood circulation promoting and blood stasis dispelling, and recover QI and blood unobstructed, hemostasis of regulating the flow of vital energy, heat clearing away are fallen apart stagnant.
Two, damage the treatment in mid-term, i.e., in the time in 3-6 weeks, outside continuity activating blood and resolving stasis and treating, mainly with blood nourishing acupuncture-stimulating, the liver and the kidney tonifying, promotes muscles and bones healing.
Three, the treatment in later stage is damaged, namely in 7-8 time-of-weeks, to damage based on morning, intermediate period treatment, to take good care of QI and blood, promoting tissue regeneration by removing blood stasis, the liver and the kidney tonifying, continued access muscles and bones, dredging grain, relieving rigidity of joints.After above-mentioned three phases treatment, fracture patient damage with the passing of time, congestion condensation, QI and blood deficiency, grain adhesion and contracture, the amyotrophy of most of affected parts, limbs are weak, wind-cold damp pathogen, adjacent segment is stiff, ache, joint stuffiness, function of joint disappear, and the later stage also needs with relaxing muscles and tendons and activating QI and blood in the collateral therapy restore funcitons, namely at least in 9-16 time-of-weeks, substantially can recover limb function, reach knitting.As can be seen here, the damage of fracture brings inconvenience.In addition, due to traditional therapy overlong time, fracture patient long-term bed, outdoor activities reduce, Ca,P metabolism obstacle in body, endocrine disturbance, many undesirable elements such as malnutrition, cause the situation of healing time prolongation or disunion to occur.At present, have many medicines though clinical, contrast effect is not satisfactory, and administration time is long, and toxic and side effects is large.Especially various internal and external fixators tool is larger to the harm of fracture patient, very easily causes the chance of useless property fracture and infection of bone, not only increases misery and the worry of patient, also greatly add the financial burden of patient and family members.And reinforcement and elimination in combination, nourishing blood and promoting blood circulation trophic function type, administration time is short, determined curative effect, have no side effect, improve Ca,P metabolism effect in body, short time is dismountable fixing, recovery limbs normal physiological function, sequela is not stayed to fracture patient treatment, that can afford to use, relieved Chinese patent medicine, commercially there is not yet on sale.
Summary of the invention
Object of the present invention, is to provide a kind of Chinese medicinal capsule for the treatment of fracture, and the present invention adopts fracture internal treatment, and reinforcement and elimination in combination, nourishing blood and promoting blood circulation, without acute or subacute toxicity.There is invigorating the liver and kidney, blood circulation regulating, reuniting the fractured tendons and bones, treatment injured, dissipating blood stasis tissue regeneration promoting, promoting blood circulation and detumescence, removing obstruction in the collateral to relieve pain, relaxing muscles and tendons bone strengthening effect, can promote that granulation is newborn, growth of spur, the effect such as accelerating union of bone fracture and bone-setting pain stopping.
the technical scheme adopted
Treat a Chinese medicine for fracture, by monarch drug, ministerial drug, adjuvant drug, medicine is mixed with, it is characterized in that monarch drug used is Radix Dipsaci, ministerial drug is Rhizoma Drynariae, adjuvant drug is Semen Cucumidis sativi, make medicine be Forging Concha Ostreae; Monarch drug, ministerial drug, adjuvant drug, the compatibility of medicine is made to be: Radix Dipsaci 150-260 grams, Rhizoma Drynariae 100-300 grams, Semen Cucumidis sativi 500--1500 gram, Forging Concha Ostreae 160-230 grams.
Treat a Chinese medicinal preparation method for fracture, comprise following processing step:
1, by proportion compatibility: get Forging Concha Ostreae 160-230 grams and be ground into fine powder and cross 120 mesh sieves, obtain fine powder (1), put into container for subsequent use.
2, by proportion compatibility: get Radix Dipsaci 150-260 grams, Rhizoma Drynariae 100-300 grams, Semen Cucumidis sativi 500-1500 grams, be ground into fine powder respectively and cross 100 mesh sieves, by sieved fine powder mix homogeneously, add 6-10 times of water gagings, decoct 1-3 hours, filter, obtain filtrate (2); Medicinal residues add 3-7 times of water gagings, decoct 1-2 hours, filter, obtain filtrate (3).
3, filtrate (2) and filtrate (3) are merged, be concentrated into paste, let cool.Use 75% alcohol reflux, first time adds the alcohol reflux 3 hours being equivalent to crude drug 4 times amount, and second time adds the alcohol reflux 1 hour of 3 times amount, merges ethanol extract, leave standstill 16-48 hours precipitations, its supernatant of siphon, recovery ethanol, make without alcohol taste in medicinal liquid, medicinal liquid deposits 16-24 hours, refilter, in gained filtrate, add fine powder (1) prepared by step (1), stir, dry sterilization, by setting metering incapsulate, to obtain final product.
pathogenesis and the rule for the treatment of
The treatment of Bone injury disease, with clinical examination and auxiliary examination for foundation, comprehensively should analyze, implement be association of activity and inertia, muscles and bones lays equal stress on, the Therapeutic Principle of internal and external application, cooperation between the doctors and patients.Internal treatment is the method by taking Chinese patent drugs for treatment bone injury disease.The measures such as attacking the pathogens first and then tonifying, reinforcement and elimination in combination or tonifying first and then eliminating the pathogen can be adopted by concrete condition.The present invention adopts internal treatment and reinforcement and elimination in combination.Bone injury internal treatment is according to " differential diagnosis in terms of eight principles " gained, and that suits the medicine to the illness is new and oldly analyzed, comprehensive, conclude, and in conjunction with the deficiency and excess of human righteousness and the order of importance and emergency of bone injury illness, can treat with disease.Qing Dynasty Chen Shi Duo says: " method for the treatment of by oral administration of medicines, must take blood circulation promoting and blood stasis dispelling as elder generation, the blood not rule for the treatment of stasis of blood must go, and the stasis of blood does not go then bone not connect "." all medicines with sour nourishing bone, with pungent nourishing muscle and tendon, with salty foster arteries and veins, foster the spirit of nobility with hardship, with sweet foster meat, support key with sliding, allly have the wounded, by its medicine beggar ".So in bone healing, necessary first blood circulation promoting and blood stasis dispelling, to reach the object of dissipating blood stasis tissue regeneration promoting.In addition, due to injured in the sinews or bones, certainly will internal organs be involved, very then hematozemia disappears marrow, to the function of internal organs function and Liver and kidney nourishing muscle and tendon bone growth promoting, also certainly leads to harmful effect.Therefore, internal organs must be in harmonious proportion, benefiting vital QI and blood, nourishing the liver and kidney, with the favorable factor caused or promote bone muscle impairment to heal, regulate zang-fu differentiation function, promote local blood circulation, improve endocrine and metabolic function, impel muscles and bones over the course for the treatment of, healed in repair process.
The importance of Chinese medicine to fracture correct application internal treatment has sufficient understanding for a long time.Say as far back as the Song dynasty " Holy help Dui record traumatic fracture a muscles and bones and traumatic fracture pain ": " people all one's life, blood Ying Qi defend, the infinite or muscles joint of circulating, traumatiing fracture by mistake, then between stagnation of QI-blood pain, storehouse soldier, lose what conditioning, institute must not hinder, then must not continue ".Point out the effective measures of Coryza Treated by Syndrome Differentiation.Illustrate local damage and overall relation.Clinical treat fracture time must mutually take into account.The traditional Chinese medical science is thought " liver governing tendons, kidney governing bones, the nourishing muscle and tendon of liver hemopoietic, kidney storing essence bone growth promoting ".The substantial connection of Liver and kidney and muscles and bones is described, so reinforcement and elimination in combination, nourishing blood and promoting blood circulation when controlling injured, with invigorating the liver and kidney, blood circulation regulating, reuniting the fractured tendons and bones, blood circulation promoting and blood stasis dispelling, dissipating blood stasis tissue regeneration promoting, reducing swelling and alleviating pain, bone and muscle strengthening are the rule for the treatment of.
Chinese traditional treatment fracture is emphasized to handle reduction well, fixes, is done exercises, medication four Important Relations, wherein uses Drug therapy fracture to be advantage and the feature of orthopedics and traumatology of Chinese medicine.In side, Radix Dipsaci has invigorating the liver and kidney, reuniting the fractured tendons and bones, tune blood promote blood circulation effect; Rhizoma Drynariae has invigorating the liver and kidney, reuniting the fractured tendons and bones, treatment injured, dissipating blood stasis tissue regeneration promoting, promoting blood circulation and stopping pain effect equally; Semen Cucumidis sativi can reunion of fractured tendons and bones, removing dampness of dispeling the wind, eliminate the phlegm and breathe heavily, arthralgia effect; Forging Concha Ostreae have hard masses softening and resolving, can tonifying YIN YANG hyperactivity suppressing, the caused irritated insomnia of hyperactivity of YANG due to deficiency of YIN, one's ears rang and spots danced before one's eyes, hectic fever night sweat, astringent therapy, pain relieving, antacid effect.All medicines 5 play blood circulation and channel invigorating, liver and kidney tonifying, dissipating blood stasis tissue regeneration promoting, promoting blood circulation and detumescence, thin muscle bone strengthening effect mutually altogether.Have and impel affected part granulation new life, growth of spur, accelerating union of bone fracture and bone-setting pain stopping effect.
Character: light brown powder, salty in the mouth, micro-hardship.
Specification: 400mg/ grain.
Storage: seal, put shady and cool place.
Function: continued access blood vessels, blood circulation promoting and blood stasis dispelling, dissipating blood stasis tissue regeneration promoting, thin muscle dredging collateral, reunion of fractured tendons and bones.
Cure mainly: all kinds of fracture.
Usage and dosage: oral one time 4,3 times on the one, 30 minutes ante cibum (medicine) being taken before meal use.
fang Xie
Radix Dipsaci: the bitter temperature of nature and flavor, has invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating effect." herbal classic " is said: " Radix Dipsaci is not only good at the muscles and bones wrecked of continuing, and is more that it is good at mending Radix Dipsaci blood trouble arteries and veins, so gain the name "." non-this of blood vessels that breaks do not continue, non-this of the muscles and bones of being hindered is not supported, and the stagnant joint of institute is non-, and this is unfavorable, pregnant this uneasiness non-of the tire damaged ".This product long-term taking can increase QI and blood, for the cause of disease therefore be monarch drug.
Rhizoma Drynariae: its bitter in the mouth, warm in nature, has liver and kidney tonifying, reuniting the fractured tendons and bones, treatment injured, promoting blood circulation and stopping pain effect, and " legendary god of farming's book on Chinese herbal medicine " is said: " liver and kidney tonifying, can bone and muscle strengthening, can wind-damp dispelling, bitter in the mouth is warm in nature is good at promoting blood circulation, and treatment fracture has promoting blood circulation and stopping pain effect ".5 monarchs drug, improve curative effect therefore be ministerial drug.
Semen Cucumidis sativi: different name Ha Lisu, platymiscium cucumber seeds, containing fatty oil, wherein have fatty acid, oleic acid, linoleic acid, Palmic acid, stearic acid etc., " Chinese herbal medicine is commonly used in Liaoning " is said: " reunion of fractured tendons and bones, removing dampness of dispeling the wind, eliminate the phlegm and breathe heavily, arthralgia ".Help the monarch and his subjects medicine thus for adjuvant drug.
Forging Concha Ostreae: nature and flavor are salty and bitter, have tonifying YIN YANG hyperactivity suppressing, restrain astringent or styptic treatment for spontaneous sweating, hard masses softening and resolving effect, " TCM Recipe medicine " is said: " salty in the mouth matter weight, is longer than hard masses softening and resolving, energy tonifying YIN YANG hyperactivity suppressing, the caused irritated insomnia of hyperactivity of YANG due to deficiency of YIN, the diseases such as one's ears rang and spots danced before one's eyes, hectic fever night sweat ".After this product puckery, forging, the property of astringent therapy strengthens, and has pain relieving, antacid effect, this moral character and and delay, energy coordinating the actions of various ingredients in a prescription therefore for making medicine.
Medication of the present invention is reasonable, proportioning science, scrupulous dialectical, correctly treats.Short to treatment fracture administration time, determined curative effect.Implementing internal treatment's principle of Bone injury disease, by taking Chinese patent drugs for treatment method, reinforcement and elimination in combination method should be adopted, as follows with " three phases " treatment:
1, early injury is based on blood circulation promoting and blood stasis dispelling, reunion of fractured tendons and bones, namely 1-7 days.Fracture, the diseases such as dislocation, muscle and tendon injury, gently then affect passages through which vital energy circulates QI and blood popular, depressedly do not fall apart, heavy then damage blood vessels, stagnant blood is detained, passages through which vital energy circulates is jammed, QI and blood is popular is obstructed.So, the initial stage to mend Radix Dipsaci blood trouble arteries and veins, to improve blood circulation, blood circulation promoting and blood stasis dispelling, dredge ruton arteries and veins.Reunion of fractured tendons and bones, just so-called: " stasis of blood is not gone, then fresh blood must not be given birth to also ".
2, mid-term is damaged based on blood nourishing acupuncture-stimulating, liver and kidney tonifying, namely 8-14 days.Menophania treatment qi depression to blood stasis successive elimination, swelling is disappeared gradually, and muscles and bones breaking part newly granulates, callus tentatively generates, pain relief, temperature recovery are normal, but muscles and bones acid is weak, and time has and has a pain, illustrate that congestion is not yet changed to the greatest extent, completely not unimpeded through resuming of pulse, QI and blood still charge less is prosperous.So mid-term treats on basis in the early stage, still with nourishing blood and promoting blood circulation, liver and kidney tonifying, activating muscle and blood, reunion of fractured tendons and bones, reducing swelling and alleviating pain to promote union of fracture.
3, damage the later stage with invigorating the liver and kidney, blood circulation regulating, promoting the flow of QI in the collateral by warming the meridian, bone and muscle strengthening are main, namely 14-21 days.Fracture and injury through just, intermediate period treatment dissipating blood stasis tissue regeneration promoting, muscles and bones is continued, then adds the current period and continue medication treatment fracture and substantially heal.But muscles and bones is not yet firm, and normal with deficient qi and blood, and the diseases such as limbs are weak, ankylosis, so the current period should with invigorating the liver and kidney, blood circulation regulating, hard masses softening and resolving, promoting the flow of QI in the collateral by warming the meridian, bone and muscle strengthening.
Comprehensively above-mentioned three phases treatment fracture heals substantially, and internal and external fixators tool all can be dismantled, and under the prerequisite that health does not bear a heavy burden, can do and recover limb function exercise, reach heal completely with it.
Animal acute toxicity, sub-acute toxicity test:
The present invention has promotion skeleton to the Absorption of calcium, improves calcium and phosphorus level, is conducive to bone calcification and bone mineral formation.Crude extract of the present invention has significant facilitation to chicken skeleton development, growth.The weight in wet base of administration group chicken femur and body weight, unit length cortical bone Ca, P, HP, HexN content are higher than matched group.Extracting solution of the present invention deposits obvious facilitation to Embryo Gallus domesticus collagen base Ca, the P in tissue culture, improve activity of acid phosphatase in tissue, promote proteoglycan synthesis, suppress collage synthesis, simultaneously to growth promoter, blood cytology, the content of hemoglobin of chicken, liver and renal function all have no significant effect, pathological anatomy check result, each main organs also has no toxic pathological change.
clinical experiment
The present invention can not only impel growth of spur, accelerating union of bone fracture and bone-setting pain stopping effect, and can suppress vascular permeability, improves local blood circulation effect.The routine pure of clinical observation 153, closure, fracture patient after manual reduction, result is that swell and ache disappearance, fracture para-position of affected part is good to line, have seriality growth of spur, the complete or basic recuperator of function, union of fracture effective percentage is 78.65%, pain relieving effective percentage is 97.8%, detumescence effective percentage is 96.43%, and blood stasis dispelling effective percentage is 97.75%, and limb functional recover effective percentage is 91.90%.
specific implementation method
Treating a Chinese medicine for fracture, is be mixed with by Radix Dipsaci 200 grams, Rhizoma Drynariae 200 grams, Semen Cucumidis sativi 1000 grams, Forging Concha Ostreae 200 grams.
Treat a Chinese medicinal preparation method for fracture, comprise following processing step:
1, by proportion compatibility: get Forging Concha Ostreae 200 grams, be ground into fine powder and cross 120 mesh sieves, obtain fine powder (1), put into container for subsequent use.
2, by proportion compatibility: get Radix Dipsaci 200 grams, Rhizoma Drynariae 200 grams, Semen Cucumidis sativi 1000 grams, be ground into fine powder respectively and cross 100 mesh sieves, by sieved fine powder mix homogeneously, first time adds 8 times of water gagings, decocts 2 hours, filters, obtains filtrate (2).In medicinal residues, second time adds 6 times of water gagings again, decocts 1 hour, filters, obtains filtrate (3).
3, filtrate (2) and filtrate (3) are merged, be concentrated into paste, let cool, use 75% alcohol reflux, first time adds the alcohol reflux 3 hours being equivalent to crude drug 4 times amount, second time adds the alcohol reflux 1 hour of 3 times amount, merge ethanol extract and leave standstill 48 hours precipitations, its supernatant of siphon, reclaims ethanol, makes in medicine without alcohol taste, medicinal liquid places 24 hours, refilter, in gained filtrate, add fine powder (1) prepared by step (1), stir, dry sterilization, fill capsule, each capsule is containing this medicine of 400mg and get final product.
Claims (3)
1. treat a Chinese medicine for fracture, be by monarch drug, ministerial drug, adjuvant drug, medicine is mixed with, it is characterized in that monarch drug used is Radix Dipsaci, ministerial drug is Rhizoma Drynariae, adjuvant drug is Semen Cucumidis sativi, make medicine be Forging Concha Ostreae; Monarch drug, ministerial drug, adjuvant drug, make the compatibility of medicine be: Radix Dipsaci 150-260 grams, Rhizoma Drynariae 100--300 gram, Semen Cucumidis sativi 500-1500 grams, Forging Concha Ostreae 160-230 grams.
2. a kind of Chinese medicine for the treatment of fracture according to claim 1, is characterized in that being mixed with by Radix Dipsaci 200 grams, Rhizoma Drynariae 200 grams, Semen Cucumidis sativi 1000 grams, Forging Concha Ostreae 200 grams.
3. a kind of Chinese medicinal preparation method for the treatment of fracture according to claim 1, is characterized in that comprising following processing step:
(1) by proportion compatibility: get Forging Concha Ostreae 160-230 grams, be ground into fine powder and cross 120 mesh sieves, obtain fine powder 1., put into container for subsequent use;
(2) by proportion compatibility: get Radix Dipsaci 150-260 grams, Rhizoma Drynariae 100-300 grams, Semen Cucumidis sativi 500-1500 grams, be ground into fine powder respectively and cross 100 mesh sieves, by sieved fine powder mix homogeneously, first time adds 6-10 times of water gagings, decocts 1-3 hours, filters, obtains filtrate 2.; In medicinal residues, second time adds 3-7 times of water gagings again, decocts 1-2 hours, filters, obtains filtrate 3.;
(3) 3. 2. filtrate is merged with filtrate, be concentrated into paste, let cool, use 75% alcohol reflux, first time adds the alcohol reflux 3 hours being equivalent to crude drug 4 times amount, second time adds the alcohol reflux 1 hour of 3 times amount, merges ethanol extract, leaves standstill 48 hours precipitations, its supernatant of siphon, reclaim ethanol, make without alcohol taste in medicine, medicinal liquid was placement 16-48 hours, refilter, in gained filtrate, add the obtained fine powder of step (1) 1., stir, dry sterilization, by setting metering filling capsule, to obtain final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709378A (en) * | 2005-06-03 | 2005-12-21 | 江苏康缘药业股份有限公司 | Medicinal composition for promoting bone fracture healing and its preparing method |
| CN102755368A (en) * | 2012-07-18 | 2012-10-31 | 张君 | Bone setting traditional Chinese medicine and preparation method thereof |
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- 2015-06-12 CN CN201510320319.7A patent/CN104922192A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709378A (en) * | 2005-06-03 | 2005-12-21 | 江苏康缘药业股份有限公司 | Medicinal composition for promoting bone fracture healing and its preparing method |
| CN102755368A (en) * | 2012-07-18 | 2012-10-31 | 张君 | Bone setting traditional Chinese medicine and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘青: "《100种健康食物排行榜》", 31 August 2009, 中国铁道出版社 * |
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