CN104908321B - The control method of the Pneumatic double-acting biology 3D printing nozzle of inside and outside double screw cap structures - Google Patents
The control method of the Pneumatic double-acting biology 3D printing nozzle of inside and outside double screw cap structures Download PDFInfo
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- CN104908321B CN104908321B CN201510265391.4A CN201510265391A CN104908321B CN 104908321 B CN104908321 B CN 104908321B CN 201510265391 A CN201510265391 A CN 201510265391A CN 104908321 B CN104908321 B CN 104908321B
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Abstract
The invention discloses a kind of control method of the Pneumatic double-acting biology 3D printing nozzle of inside and outside double screw cap structures, using pressure classification input mode：When inputting the first stage pressure, active force promotes the downward sliding motion of piston component, moves to maximum sliding displacement as h, completes to select working condition nozzle；When further improving pressure input, inner swiveling closing valve port is opened, and gas squeezes out barrel inner cell liquid and flowed downward out from needle passage is squeezed out into feeding cylinder internal press chamber b.Multiple nozzles of the present invention can control deposition height with a motor and corresponding transmission device in vertical direction.And multiple ejection head units drive the h that moves downward of ejection head unit internal component in itself using the Pneumatic pressure of extrusion, and the nozzle of work selected from other nozzles.In this way, both having avoided interference of other nozzles to the forming face that works, system structure is also greatly simplified, reduces cost.
Description
Technical field
The present invention relates to a kind of the pneumatic of double screw cap structures inside and outside more file printings is applicable in for biological tissue's manufacture
The control method of double acting biology 3D printing nozzle prints for cell and biomaterial, belongs to tissue engineering technique and biology
3D printing field.
Background technology
For being damaged the treatment of bulk soft tissue and internal organs, human tissue organ's transplanting, which is that one kind is extremely effective, to be controlled
Treatment method.But since the problems such as shortage of organ donor source, immunological rejection exists, organ transplant treatment is deposited in practice
In the difficulty for being difficult to overcome.And the proposition of organizational project opens new approach in order to solve the above problem.Organizational project is by work
Cell is conformed to by some way in biomaterial matrix or the stent of preparation, comes constructing function tissue substituent.Then
Implantation within a patient after the tissue substituent of structure is cultivated replaces original pathological tissues organ to recover original body
Body function is realized to disease treatment.The research of organization engineering skin at present and with regard to the effective of the good development prospect of organizational project
Illustration.
Traditional Tissue Engineering Study has been limited to cell implanted prosthetics, i.e., cell " is implanted on stent to " this tissue
In engineering inherent technology link, different types of cell and biomaterial can not be pin-pointed to internal stent different spaces position
It puts.In fact, with the propulsion of Tissue Engineering Study, research work progressively prolongs life in terms of bulk soft tissue and internal organs,
Since these tissues and organ are often containing various kinds of cell and biomaterial, and different cells or material have specific space
Arrangement, therefore above-mentioned technical limitation more highlights.
In recent years, the fast development of 3D printing technique opens new manufacture production model for industry manufacture.In biology
In field, the technologies such as biometric print, cell three-dimensional controlled tissue are also applied and given birth to.These technologies have operation individual cells or list
The ability of ingredient microsize drop, can the accurately spatial position of control operation object and distribution, for realize bulk tissue
With in organ building process not the spatial position of allogenic cell and biomaterial deposition have huge meaning.Therefore, exploitation life
Object printing technique is the inexorable trend of future organization engineering research.And in a typical biometric print machine, critical component it
One is exactly to shape nozzle.
In order to meet the structure requirement of the various kinds of cell of bulk soft tissue and internal organs and material, it is necessary to which to develop one kind more
Material forming nozzle.More material forming nozzles are generally mounted in parallel using multiple nozzles in sustained height, and each nozzle can be located
Manage a kind of material or cell.General in print procedure only to work there are one nozzle, sustained height is in other sprays for shape of awaiting orders
Head may have the interference to structure texture forming face.It is this to solve the problems, such as, Pu Xiang universities of South Korea Dong-Woo Cho religions
More nozzle tissue/organs manufacture system of team's exploitation is awarded, nozzle segment set is into 6 groups of nozzles, wherein 4 groups are pneumatic extrusion molding
Nozzle, 4 groups of position piston extrusion molding nozzles.For nozzle work and two states of awaiting orders, every group of nozzle is equipped with a driving electricity
The entire nozzle component for participating in work by transmission mechanism is transferred to and is suitble to height, awaited orders using difference in height and other by machine
State nozzle distinguishes, it is possible to prevente effectively from the situation that nozzle disturbs forming face in print procedure of awaiting orders.But due to applying
Driving device is excessive, and system is relative complex, and cost is higher, and without scalability.
In order to ensure to distinguish two kinds of nozzle states of awaiting orders and work, disturbed condition is avoided to occur, while simplifies it and is
System structure, improves scalability, and the present invention provides a kind of Pneumatic double-acting biology 3D printing nozzle knot towards more file printings
Structure.
The content of the invention
Technical scheme is as follows：
A kind of control method of the Pneumatic double-acting biology 3D printing nozzle of inside and outside double screw cap structures, it is characterised in that：
Before printing, cell and biomaterial solution are attached in barrel, under original state, under compression spring effect,
Sliding piston is in top, and all extrusion molding units are in same state, therefore needle tip is located at sustained height；Miniature
It compresses under spring effect, spool is located at top, and the valve port of inner swiveling closing is also at closed state；
When needing a certain extrusion molding cell operation, the tracheae being connected with quick connector inputs gas, first in cavity a
Certain pressure is formed, when pressure reaches P1, overcomes the elastic force of compression spring in the active force that piston and inward turning cap surface generate,
Promotion slides downwards with piston and coupled inner core, barrel and syringe needle, and maximum sliding displacement is Δ h, in this way, by using
Sliding displacement Δ h distinguishes the extrusion molding unit of working condition and other armed state extrusion molding units, avoids treating
Interference of the life state extrusion molding unit to forming face, at this point, under the action of Mini compressed spring, the valve port of inner swiveling closing is still located
The not unicom between closed state, cavity a and cavity b；
Input pressure is further improved, when pressure reaches P2, active force of the pressure in spool upper surface overcomes miniature pressure
The elastic force of contracting spring drags valve core movement, and valve port is opened, unicom between cavity a and cavity b, gas from cavity a by valve port and
Venthole enters cavity b, maintains or continues to improve input pressure, the pressure P3 formed inside cavity b, in the effect of pressure P3
Under, solution is at the uniform velocity squeezed out from extrusion syringe needle in barrel, is fallen in forming face.
The Pneumatic double-acting biology 3D printing nozzle structure includes at least two groups of extrusion molding units, and described is extruded into
Shape unit includes lower housing, upper shell, outer spiral cover, piston, inner core, compression spring, barrel, inner swiveling closing, quick connector and extrusion
Syringe needle；The upper shell is connected with lower housing, and the outer spiral cover is connected by screw thread with upper shell, the quick connector and outward turning
Lid connection, piston installation with inside lower housing, the compression spring is mounted between piston and lower housing, the inner core with
Piston connects, and the barrel is mounted in inner core, and barrel opening is connected through a screw thread an inner swiveling closing, the extrusion syringe needle
Mounted on the bottom of barrel.
Preferably, the upper shell is closely connected with lower housing by screw, and contact surface embedding sealing material is sealed；
The quick connector is connected through a screw thread with outer spiral cover, and various outer diameter hoses can be connected according to institute's erection joint specification difference.
Preferably, the piston can carry out sliding motion inside lower housing, and downward maximum displacement Δ h, piston is under
Sealing ring between housing is installed and realizes sealing；The compression spring is mounted between piston and lower housing, and spring is in compression shape
State；The lower surface of the upper shell can limit sliding piston and be popped up by compression spring.
Preferably, the inner core can be with piston sliding motion.
Preferably, the inner swiveling closing includes inward turning lid housing, valve pocket, Mini compressed spring and spool；The valve pocket with it is interior
It is connected by screw between spiral cover housing together, uniformly distributed two radial direction ventholes on valve pocket；The spool is mounted in valve pocket
Portion, can be along valve pocket endoporus sliding motion, good seal between spool and valve pocket；The Mini compressed spring is mounted on spool and valve
Between set, in compressive state；Inner swiveling closing housing central bore is covered seal under the action of the spring by normal condition bottom spool, inward turning
Lid housing top center is equipped with valve port.
Preferably, the spiral cover, upper shell, lower housing, piston, inner core and inner swiveling closing form a cavity a；The material
Cylinder, inner swiveling closing and extrusion syringe needle form a cavity b；It is separated between cavity a and cavity b by inner swiveling closing structure.
Multiple nozzles of the present invention can control deposition high with a motor and corresponding transmission device in vertical direction
Degree.And multiple ejection head units move downward Δ h drive ejection head unit internal component in itself using the Pneumatic pressure of extrusion, it will
The nozzle of work is selected from other nozzles.In this way, both having avoided interference of other nozzles to the forming face that works, also greatly simplify and be
System structure, reduces cost；
Each ejection head unit of the present invention is compact-sized, and transmission requires low, suitable extensive spread, combination operation,
Greatly promote the ability to work of equipment.
When printing finishes, reduced by proportioning valve or opening pressure inputs, the air pressure in cavity a and cavity b recovers normal
Pressure, being moved upwards in Mini compressed spring effect bottom spool disconnects valve port and radial direction venthole, while in compression spring effect
Under, for piston upwards at maximum displacement, drive needle retractable to elemental height, entire nozzle component is restored to initial shape
State.
Description of the drawings
Fig. 1 is a kind of Pneumatic double-acting biology 3D printing nozzle structure towards more file printings of 2 × 2 forms.
Fig. 2 is that a kind of Pneumatic double-acting biology 3D printing nozzle structure towards more file printings of 2 × 2 forms is faced
Figure.
Fig. 3 is that a kind of Pneumatic double-acting biology 3D printing nozzle structure towards more file printings of 2 × 2 forms is overlooked
Figure.
Fig. 4 is that a kind of extrusion molding unit of the Pneumatic double-acting biology 3D printing nozzle structure towards more file printings shows
It is intended to.
Fig. 5 is the schematic diagram of inner swiveling closing structure.
Fig. 6 is the two states of ejection head unit：Left hand view is armed state, and right side is in working condition.
Specific embodiment
Below in conjunction with the accompanying drawings 1~6 and the embodiment concrete structure, operation principle and the course of work that further illustrate the present invention
Content.
A kind of control method of the Pneumatic double-acting biology 3D printing nozzle of inside and outside double screw cap structures：
Before printing, cell and biomaterial solution are attached in barrel 10, under original state, acted in compression spring 9
Under, sliding piston 8 is in top, and all extrusion molding units are in same state, therefore 13 top of syringe needle is located at sustained height；
Under the effect of Mini compressed spring 17, spool 16 is located at top, and the valve port 141 of inner swiveling closing is also at closed state；
When needing a certain extrusion molding cell operation, the tracheae being connected with quick connector 12 inputs gas, first in chamber
Body a forms certain pressure, when pressure reaches P1, overcomes compression spring 9 in the active force that piston 8 and 11 surface of inner swiveling closing generate
Elastic force, promote and slid downwards with piston 8 and coupled inner core 18, barrel 10 and syringe needle 13, maximum sliding displacement is Δ
H, in this way, by using sliding displacement Δ h by the extrusion molding unit of working condition and other armed state extrusion molding lists
Member distinguishes, and avoids interference of the armed state extrusion molding unit to forming face, at this point, in the effect of Mini compressed spring 17
Under, the valve port 141 of inner swiveling closing 11 is still in closed state, not unicom between cavity a and cavity b；
Input pressure is further improved, when pressure reaches P2, active force of the pressure in 16 upper surface of spool overcomes miniature
The elastic force of spring 17 is compressed, dragging spool 16 moves, and valve port 141 is opened, unicom between cavity a and cavity b, and gas is from cavity a
Cavity b is entered by valve port 141 and venthole 151, maintain or continues to improve input pressure, the pressure formed inside cavity b
P3, under the action of pressure P3, solution is at the uniform velocity squeezed out from extrusion syringe needle 13 in barrel 10, is fallen in forming face.
Entire jet head sets are mounted in three-dimensional movement platform, there is the three-dimensional coordinate and motion path of platform courses nozzle.
It, can be with equilibrium bomb by the rigidity of spring 9 and effective pressure active area, quality and the coefficient of friction of sliding assembly
Relation between power, gravity, frictional force and pressure can obtain different size of pressure P1 values.
The Pneumatic double-acting biology 3D printing nozzle of inside and outside double screw cap structures described in the method for the present invention, includes at least two groups
Ejection head unit.Exemplified by the present invention is in the form of Fig. 1, the first ejection head unit 1, the second ejection head unit 2,3 and of the 3rd ejection head unit are included
Four groups of ejection head units including 4th ejection head unit 4, actual nozzle quantity and arrangement form can do self-defined.
Four groups of ejection head unit cellular constructions are identical, linked together by same lower housing 5.Each ejection head unit includes solid
Determine component and movable part two parts composition.Fixed component includes upper shell 6, lower housing 5, outer spiral cover 7 and quick connector 12,
Upper shell 5 is linked together with lower housing 6 by plug screw, and contact surface does encapsulation process with sealing material；Outer spiral cover 7 passes through screw thread
Mode is connected with upper shell 7, and contact surface has good sealing, and addition can voluntarily remove spiral cover 7 when printing liquid or cleaning sprayer；Soon
Connection-peg 12 is connected through a screw thread mode on upper shell 7, can be by nozzle by the quick connector 7 for replacing different size
It is connected on the power input hose of various outer diameter.
Internal movable part includes piston 8, inner core 18, compression spring 9, barrel 10 and inner swiveling closing 11 and forms.Piston 8 exists
It inside lower housing 5, is co-axially mounted, can be slided up and down along 5 inner wall of lower housing, piston 8 is directly used with lower housing with lower housing 5
Sealing ring 14 seals；It compresses spring 9 to be mounted between lower housing 5 and piston 8, in compressive state, compresses bullet under original state
Spring 9 is promoted at piston 8 to maximum displacement, i.e., the upper surface of piston 8 is contacted with the lower surface of upper shell 6；Inner core 18 is solid with piston 8
It is connected together, can move up and down with piston 8, barrel 10, contact surface good seal are inserted with inside inner core 18；It is opened in barrel 10
Inner swiveling closing 11 is also equipped at head, inner swiveling closing 11 is connected by external screw thread 141 with barrel internal thread, voluntarily can be removed or be installed.
Inner swiveling closing structure includes spiral cover housing 14, valve pocket 15, spool 16 and microsprings 17.Valve pocket 15 is mounted on spiral cover shell
On body 14, connected by the screw being axially distributed, contact surface sealing material good seal；Spool 16 is mounted in valve pocket 15
Portion can slide up and down in valve pocket 15；Microsprings 17 are mounted between valve pocket 15 and spool 16, in compressive state, initially
Bottom spool 16 is acted under state in compression spring 16 to close valve port 141；Spool 16 and 15 contact surface good seal of valve pocket；Valve pocket
15 radial directions are provided with radial direction venthole 151.
When valve port 141 is passed through a certain size pressure, spool 16 can be promoted to move, make valve port 141 and radial direction venthole
151 are connected.
Syringe needle 13 is mounted on 18 lower ends on barrel, and injection needle or Glue dripping head may be employed, and can also use self-control syringe needle.
Multiple nozzles of the present invention can control deposition high with a motor and corresponding transmission device in vertical direction
Degree.And multiple ejection head units move downward Δ h drive ejection head unit internal component in itself using the Pneumatic pressure of extrusion, it will
The nozzle of work is selected from other nozzles.In this way, both having avoided interference of other nozzles to the forming face that works, also greatly simplify and be
System structure, reduces cost；
Each ejection head unit of the present invention is compact-sized, and transmission requires low, suitable extensive spread, combination operation,
Greatly promote the ability to work of equipment.
When printing finishes, reduced by proportioning valve or opening pressure inputs, the air pressure in cavity a and cavity b recovers normal
Pressure, acting on bottom spool 16 in Mini compressed spring 17 and move upwards disconnects valve port 141 and radial direction venthole 151, while is pressing
Under contracting spring 9 acts on, piston 8 is moved upward at maximum displacement, and syringe needle 13 is driven to retract to elemental height, entire nozzle component
It returns to original state.
Claims (1)
1. a kind of control method of the Pneumatic double-acting biology 3D printing nozzle of inside and outside double screw cap structures, it is characterised in that：
The 3D printing nozzle structure includes at least two groups of extrusion molding units, and the extrusion molding unit includes lower housing
(5), upper shell (6), outer spiral cover (7), piston (8), inner core (18), compression spring (9), barrel (10), inner swiveling closing (11), fast insert
Connector (12) and extrusion syringe needle (13)；The upper shell is connected with lower housing, and the outer spiral cover is connected by screw thread with upper shell,
The quick connector is connected with outer spiral cover, and the piston is mounted on inside lower housing, and the compression spring is mounted on piston under
Between housing, the inner core is connected with piston, and the barrel is mounted in inner core, and barrel opening is connected through a screw thread in one
Spiral cover, the extrusion syringe needle (13) are mounted on the bottom of barrel (10)；
The inner swiveling closing includes inward turning lid housing, valve pocket, Mini compressed spring and spool；Between the valve pocket and inward turning lid housing
It is connected by screw together, uniformly distributed two radial direction ventholes on valve pocket；The spool is mounted on inside valve pocket, can be along valve pocket
Hole sliding motion, good seal between spool and valve pocket；The Mini compressed spring is mounted between spool and valve pocket, in pressure
Contracting state；Inner swiveling closing case top center is equipped with valve port；
Before printing, cell and biomaterial solution are attached in barrel (10), under original state, acted in compression spring (9)
Under, sliding piston (8) is in top, and all extrusion molding units are in same state, therefore syringe needle (13) top is positioned at same
Highly；Under Mini compressed spring (17) effect, spool (16) is located at top, and the valve port (141) of inner swiveling closing is also at closing shape
State；
When needing a certain extrusion molding cell operation, the tracheae being connected with quick connector (12) inputs gas, first in cavity a
Certain pressure is formed, when pressure reaches P1, overcomes compression spring in the active force that piston (8) and inner swiveling closing (11) surface generate
(9) elastic force promotes piston (8) and the inner core (18), barrel (10) and the syringe needle (13) that are connected with piston (8) to slide downwards, most
Big sliding displacement is Δ h, in this way, the extrusion molding unit of working condition is awaited orders with other by using sliding displacement Δ h
State extrusion molding unit distinguishes, and interference of the armed state extrusion molding unit to forming face is avoided, at this point, in Mini compressed
Under the action of spring (17), the valve port (141) of inner swiveling closing (11) is still in closed state, not unicom between cavity a and cavity b；
Input pressure is further improved, when pressure reaches P2, active force of the pressure in spool (16) upper surface overcomes miniature pressure
The elastic force of contracting spring (17), dragging spool (16) move, and valve port (141) is opened, unicom between cavity a and cavity b, and gas is from chamber
Body a into cavity b, is maintained by valve port (141) and venthole (151) or is continued to improve input pressure, formed inside cavity b
Pressure P3, under the action of pressure P3, barrel (10) interior solution is at the uniform velocity squeezed out from extrusion syringe needle (13), is fallen in forming face.
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| CN201510265391.4A CN104908321B (en) | 2015-05-22 | 2015-05-22 | The control method of the Pneumatic double-acting biology 3D printing nozzle of inside and outside double screw cap structures |
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Cited By (1)
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| IT201900000999A1 (en) * | 2019-01-23 | 2020-07-23 | Faiveley Transport Italia Spa | Railway braking device and procedure for making a railway braking device |
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| MX2018009683A (en) * | 2016-02-11 | 2019-06-10 | Kuster Martin | Movable printing devices for three-dimensional printers. |
| CN106113503B (en) * | 2016-07-25 | 2019-05-21 | 华中科技大学 | A kind of back pressure type electrofluid flexible material 3D printer spray head |
| CN106493941B (en) * | 2016-12-15 | 2018-12-25 | 浙江大学 | A kind of fusion sediment type 3D printer of fast changeable printing head |
| CN107498866A (en) * | 2017-09-14 | 2017-12-22 | 广州迈普再生医学科技有限公司 | A kind of 3D printing shower nozzle automatic switching control equipment and its control method and 3D printer |
| CN110744817B (en) * | 2019-10-31 | 2020-11-06 | 中南大学 | 3D printer material flow prevention device and printing method |
| CN112339271B (en) * | 2020-10-15 | 2021-10-12 | 中国热带农业科学院农产品加工研究所 | 3D prints pneumatic control and extrudes subassembly |
| CN114147951B (en) * | 2021-11-29 | 2022-08-05 | 浙江大学 | Pneumatic multi-channel control system and method for multi-nozzle biological 3D printing system |
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| US9884318B2 (en) * | 2012-02-10 | 2018-02-06 | Adam Perry Tow | Multi-axis, multi-purpose robotics automation and quality adaptive additive manufacturing |
| CN203792905U (en) * | 2014-02-27 | 2014-08-27 | 袁梦杰 | 3D printer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201900000999A1 (en) * | 2019-01-23 | 2020-07-23 | Faiveley Transport Italia Spa | Railway braking device and procedure for making a railway braking device |
| WO2020152612A1 (en) * | 2019-01-23 | 2020-07-30 | Faiveley Transport Italia S.P.A. | Railway braking device and manufacturing method of a railway braking device |
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