CN104905244B - A kind of kidney tonifying is smart by force, food, health products or the pharmaceutical composition of prevention or/and treatment prostatic disorders - Google Patents
A kind of kidney tonifying is smart by force, food, health products or the pharmaceutical composition of prevention or/and treatment prostatic disorders Download PDFInfo
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Abstract
The invention provides a kind of food, health products or pharmaceutical composition, its raw material includes the component matched as follows：1~3 part of maca, 5~12 parts of radish juice, 0.1~2 part of honey.After maca, radish juice and honey are used in combination the present invention, synergistic function is played, available for preventing or/and treat kidney deficiency, it can also be used to the adjuvant drugs of other treatment kidney deficiency medicines, the present composition also have good anti-inflammatory, diuresis, it is antifatigue the effect of.
Description
Technical field
The present invention relates to a kind of food, health products or pharmaceutical composition.
Background technology
Maca (Maca), also known as Peruvian ginseng, maka, maca-maca, maino, ayak chichira,
Ayak willku etc., originate in 3500~4500 meters of height above sea level South America andes region be mainly distributed in Peru Puno life
State area and Peru the southeastern city of Puno, it is Cruciferae (Cruciferae) Lepidium (Lepidium) plant.
Maca is the plateau plant of Cruciferae, originates in the plateau plant in more than 4000 meters of South America Peru Andes.
There is significant effect to balanced human's hormone secretion containing exclusive macamide and maca ene.Maca has antifatigue, increase essence
Protonatomic mass, regain one's strength of body, improve impotence and premature ejaculation, improve sleep, anti-climacteric, active fertility, enhancing memory and other effects.And agate
Coffee is that men and women is all suitable for, and also has good adjustment effect to the climacteric metancholia of women.
The content of the invention
It is an object of the invention to provide a kind of food, health products or pharmaceutical composition.
The invention provides a kind of food, health products or pharmaceutical composition, its bulk drug includes the component matched as follows：
1~3 part of maca, 5~12 parts of radish juice, 0.1~2 part of honey.
Further, its bulk drug includes the component matched as follows：
1~1.5 part of maca, 7~9 parts of radish juice, 0.5~0.9 part of honey.
Further, the bulk drug is made up of the component of following weight proportion：
1~3 part of maca, 5~12 parts of radish juice, 0.1~2 part of honey.
Further, the bulk drug is made up of the component of following weight proportion：
1~1.5 part of maca, 7~9 parts of radish juice, 0.5~0.9 part of honey.
Further, described bulk drug is made up of the component of following weight proportion：
1 part of maca, 8.2 parts of radish juice, 0.8 part of honey.
Wherein, the radish juice, it is made up of radish squeezing centrifuging and taking juice.
Wherein, it is the water extract or/and ethanol extract by maca, plus radish juice, honey, auxiliary material or it is complementary into
Divide the formulation being prepared.
Further, the formulation is through gastrointestinal administration formulation.
Further, the formulation is selected from granule, tablet, medicinal tea, oral liquid, capsule, pill.
The invention provides said composition to prepare prevention or/and treatment kidney deficiency；Auxiliary treatment kidney deficiency, kidney tonifying are smart by force, adjust
Save the purposes in the food, health products or medicine of hormone secretion.
The invention provides said composition to prepare prevention or/and treatment prostatic disorders, urinary system infection contamination or property work(
Purposes that can be in the food of obstacle, health products or medicine.
Present invention also offers the composition in anti-inflammatory, diuresis or antifatigue food, health products or medicine is prepared
Purposes.
Further, the prostatic disorders are prostatitis, hyperplasia of prostate, hypertrophy of the prostate.
The present invention maca, radish juice and honey are used in combination after, played synergistic function, available for prevention or/
With treatment kidney deficiency, it can also be used to which the adjuvant drug of other treatment kidney deficiency medicines, the present composition also have good anti-inflammatory, profit
The effect of urinating, be antifatigue.
Embodiment
The preparation of 1 oral liquid of the present invention of embodiment
Using maca 1kg, radish juice 7kg, honey 0.5kg as raw material, it is aided with potassium sorbate, citric acid；Maca is extracted, dense
Contracting, radish centrifuge through squeezing, then formulated, filtering, ultra-high temperature sterilization, filling, two-stage sterilization form.
The preparation of the present composition of embodiment 2
Using maca 1.5kg, radish juice 9kg, honey 0.9kg as raw material, it is aided with potassium sorbate, citric acid；Maca is extracted,
Concentration, radish centrifuge through squeezing, then formulated, filtering, ultra-high temperature sterilization, filling, two-stage sterilization form.
The preparation of the present composition beverage of embodiment 3
Using maca 1kg, radish juice 8.2kg, honey 0.8kg as raw material, it is aided with potassium sorbate, citric acid；Maca is extracted,
Mashing, centrifuging and taking juice, it is aided with citric acid, the drink that potassium sorbate is allocated, filter, embedding, high-temperature sterilization form.
Concrete technology step is：Maca, section or crushing are taken, adds 10 times of amount ethanol 0.5h, extracts 1h, filtering, obtain filtrate
And the dregs of a decoction；Filtrate recycling ethanol is concentrated into no alcohol taste, obtains clear cream；The dregs of a decoction add 10 times of amount decoctings twice (1 hour/time), filter, close
And decocting liquid twice；Merge clear cream and filtrate, obtain concentrate；Radish is cleaned, and is cut into block, is smashed with disintegrating machine, squeezes the juice；Centrifugation,
Take supernatant；Match somebody with somebody liquid with concentrate, add honey, citric acid, potassium sorbate, TRANSIENT HIGH TEMPERATURE processing, refrigerate more than 48h, centrifuging and taking
Supernatant, it is filling, sterilizing, lamp inspection, pack to obtain beverage of the present invention.(flow is shown in Fig. 1)
Beneficial effects of the present invention are proved below by way of specific pharmacodynamics test.
1 material
1.1 animal health SD mouse, cleaning grade, 18~22g of body weight, male and female half and half are limited up to large biotechnology by Chengdu
Company provides.
1.2 medicine present composition oral liquid 10g/100ml (are pressed by (being prepared by embodiment 3), single agate card alcohol extract
It is prepared by the agate card alcohol extraction procedure described in embodiment 3：Maca, section or crushing are taken, adds 10 times of amount ethanol 0.5h, extracts 1h,
Filtering, obtains filtrate and the dregs of a decoction；Filtrate recycling ethanol is concentrated into no alcohol taste, obtains clear cream), pressed before experiment human body recommended dose 5,
10th, 20 times, basic, normal, high 3 dosage groups, i.e. mouse dose are prepared as respectively with distilled water：8.35mg agates card crude drug/10g,
16.7mg agates card crude drug/10g, 33.4mg agate card crude drug/10g.
Compound aspirin tablets (Dalian Megtron pharmaceutcal corporation, Ltd, Chinese medicines quasi-word H20024666)；FUSAIMI PIAN (Shanghai
Morning sunlight pharmaceutcal corporation, Ltd, Chinese medicines quasi-word H31021074)；(the moral biotechnology industry of Chengdu Willie is limited for the very precious capsule of rhodiola root
Responsible company, the strong word G20040512 of state's food)；Hydrocortisone parenteral solution (Xinan Pharmaceutical Co., Ltd., Chinese medicines quasi-word
H50021209)；Chinkuei shin chewan pills (Yaodu Pharmaceutical Group Co., Ltd., Chinese medicines quasi-word Z13021066)；Liuwei Dihuang Wan
(Beijing Tongrentang Technology Development Co., Ltd., Chinese medicines quasi-word Z11020056), above medicine used time are made into by distilled water
Required concentration.
1.3 reagents and instrument dimethylbenzene (Chengdu Ke Long chemical reagents factory, lot number 20101111)；Other reagents are city
It is pure to sell analysis.Electronic balance (BP211D, German Sartorius Products)；(it is weighed in HZ-K3000DC, Foochow to electronic balance
Open up Electronics Co., Ltd.)；Mouse autonomic activities analyzer (ZZ-6, Chengdu TME Technology Co., Ltd.).
2 methods and result
2.1 anti-inflammation tests --- mice caused by dimethylbenzene xylene ear swelling is tested
Mouse 110,18~22g of body weight is taken, male, is randomly divided into 11 groups (every group 10)：Blank control group, Ah Si
Woods positive group, the high, medium and low dosage groups of 10g/100ml, the high, medium and low dosage group of single agate card.Gastric infusion 1 time daily, administration
Volume is 0.2ml/10g, and blank control group gives the distilled water of isometric(al), continuous 3d, 1h after last dose, by the μ l of dimethylbenzene 50
It is applied to mouse right ear two sides, left ear is not applied as control, and mouse is taken off into cervical vertebra after 30min puts to death, and is distinguished with diameter 6mm card punch
Lay round auricle at the same position of left and right ear, accurate weighing, using the difference of left and right auricle quality as swelling, inflammation inhibiting rate
(%)=(model group swelling-administration group swelling)/model group swelling × 100%.Data with Represent, use
SPSS19.0 softwares carry out the conspicuousness of more each group difference of variance analysis, the results are shown in Table 1.
The present composition beverage paraxylene induced mice auricle edema of table 1 influence (N=10)
Note：Compared with blank group, * P<0.05, * * P<0.01.
Compared with blank group, each group can significantly mitigate dimethylbenzene induced mice auricle edema；And present composition mouth
It is high compared with single agate card extract solution to take liquid swelling inhibiting rate, shows that agate card antiinflammatory action after compatibility strengthens.
2.2 diuretic test
Healthy mice 110,18~22g of body weight is taken, male and female half and half, is randomly divided into 11 groups, every group 10.Blank control
Group, frusemide positive group, the high, medium and low dosage groups of 10g/100ml, the high, medium and low dosage group of single agate card.Fasting can't help before experiment
Water 24h.Every group is first injected intraperitoneally by 0.2ml/10g physiological saline, and negative control group is filled with 0.2ml/10g water after 20min
Stomach, positive controls give 0.2ml/10g frusemide solution, and each group presses identical capacity gastric infusion.Filter paper is accurate in advance
After weighed weight, it is laid in cage, mouse is put into cage immediately after administration.Filter paper, which is taken out, every 1h weighs weight, and immediately
More renew filter paper, observe 4h altogether.Increased with weight method record filter weight, as urine volume.Data withRepresent, use
SPSS19.0 softwares carry out the conspicuousness of more each group difference of variance analysis, the results are shown in Table 2.
The present composition beverage of table 2 to mouse urine volume influence (N=10)
Note：Compared with model group, * P<0.05, * * P<0.01.
Compared with model group, the high, medium and low dosage group total volume of urine of 10g/100ml increased, and can dramatically increase urine volume,
As a result show that present composition beverage has preferable diuresis, and it is good compared with single agate card effect.
2.3 anti-fatigue test
Healthy mice 110,18~22g of body weight is taken, male and female half and half, is randomly divided into 11 groups, every group 10.Blank control
Group, the very precious capsule positive group (15mg/ml) of rhodiola root, the high, medium and low dosage groups of 10g/100ml, the high, medium and low dosage of single agate card
Group.Gavage 1 time daily, continuous 7d.It is 0.2ml/10g that volume, which is administered,.After last dose 30min, mouse tail heavy burden is given
The copper wire of body weight 5%, mouse is allowed in water temperature (25 ± 1) DEG C, depth of water 30cm swimming trunk went swimmings, observe and record mouse from putting into water
In exhaust the time that (the power standard of exhausting is that the mouse 10s that sinks under water does not emerge, and in plane can not carry out righting after pulling out anti-to power
Penetrate).Data withRepresent, the conspicuousness of more each group difference of variance analysis is carried out using SPSS19.0 softwares, is as a result seen
Table 3.
The present composition beverage of table 3 mice burden swimming power is exhausted the time influence (N=10)
Note：Compared with blank group, * P<0.05, * * P<0.01.
Compared with blank group, each group mouse swimming time is longer than blank group；Wherein 10g/100ml and single agate card
High, middle dose group mouse swimming time extremely significantly extends, and low dose group mouse swimming time significantly extends；And this hair
Bright each dosage group swimming time of composite drink has extended compared with single agate card corresponding dosage group.As a result show, this hair
Bright composite drink has preferable antifatigue effect, and is better than single agate card extract solution.
2.4 kidney tonifying are tested
2.4.1 kidney-yang deficiency
Healthy mice 120 is taken, 18~22g of body weight, male and female half and half, is randomly divided into 12 groups.Blank control group, kidney-yang deficiency mould
Type group, chinkuei shin chewan pills positive group (0.1g/ml), the high, medium and low dosage groups of 10g/100ml, the high, medium and low dosage of single agate card
Group.Every group of equal gastric infusion, administration volume is 0.2mL/10g, continuous 10d.Simultaneously in addition to normal group, remaining each group animal point
Intramuscular injection hydrocortisone parenteral solution (25mgkg/d), continuous 10d, to cause mice with kidney-yang deficiency not while administration.
Respectively before administration, after weigh, calculate changes of weight difference.30min after last dose, mouse is carried out with autonomic activities instrument
Autonomic activities is observed, and is recorded mouse autonomic activities number in 10min and is probed into number, then puts to death animal, win mouse rapidly
Adrenal gland, thymus gland, spleen, testis, prostate+seminal vesicle, uterus, ovary etc., are weighed with precise electronic Libra.Data withTable
Show, the conspicuousness of more each group difference of variance analysis is carried out using SPSS19.0 softwares, the results are shown in Table 4~6.
The present composition beverage of table 4 is to mice with kidney-yang deficiency body weight growth rate, autonomic activities number, the influence for probing into number
(N=10)
Note：Compared with kidney-yang deficiency model group, * P<0.05, * * P<0.01.
The present composition beverage of table 5 to mice with kidney-yang deficiency adrenal gland, thymus index, spleen index influence (N=
10)
Note：Compared with kidney-yang deficiency model group, * P<0.05, * * P<0.01.
The present composition beverage of table 6 to mice with kidney-yang deficiency testis, prostate, seminal vesicle, uterus, ovary influence (N=10)
Note：Compared with kidney-yang deficiency model group, * P<0.05, * * P<0.01.
As seen from table, after intramuscular injection hydrocortisone modeling 10d, there is Body weight loss in model group mouse, and activity is reduced, reaction
Blunt, chilly of becoming thin, the cold limb of tail is cool, the symptom such as few few food of drink, similar clinical kidney yang virtual state, shows modeling success.The deficient kidney of gold
The state of gas ball control group and each dosage group animal of the present composition is clearly better compared with model group.
(1) to the influence of mouse weight：Body weight significantly reduces compared with Normal group after modeling, after medication treatment, the deficient kidney of gold
Gas ball group and each dosage group body weight growth rate are above model control group.
(2) to mouse autonomic activities number, probe into the influence of number：Autonomic activities number after modeling, probe into number calibration
Normal control group significantly reduces；After medication treatment, chinkuei shin chewan pills group and each dosage group autonomic activities number pole are significantly higher than mould
Type control group, and in addition to 10g/100ml low dose groups, single agate card low dose group, remaining each group autonomic activities number is higher than just
Normal control group.Each dosage group probes into number and is above model control group；Wherein 10g/100ml height, middle dose group and single agate card
High dose group is probed into number and dramatically increased.
(3) to the influence of mouse adrenal gland, thymus index, spleen index：Mouse adrenal gland, thymus index, spleen refer to after modeling
Number significantly reduces compared with Normal group；After medication treatment, each dosage group adrenal gland, thymus index, spleen index are above model pair
According to group.
(4) to the influence of mouse sexual glands：Mouse testis, prostate, seminal vesicle, uterus, ovary weight system after modeling
Number significantly reduces compared with Normal group；After medication treatment, each dosage group testis, prostate, seminal vesicle, uterus weight coefficient are high
In model group；For ovary weight coefficient in addition to 10g/100ml low dose groups, unit agate card low dose group, each dosage group is above mould
Type control group.
As a result show, each dosage group of the present composition subtracts to mice with kidney-yang deficiency body weight, adrenal gland, thymus gland, spleen gland weight
Light and sexual glands atrophy has some improvement, and its effect is slightly better than single Ma Ka treatment groups.
2.4.2 kidney-yin deficiency
Healthy mice 120 is taken, 18~22g of body weight, male and female half and half, is randomly divided into 12 groups.Blank control group, kidney-yang deficiency mould
Type group, Liuwei Dihuang Wan positive group, the high, medium and low dosage groups of 10g/100ml, the high, medium and low dosage group of single agate card.Every group fills
Stomach is administered, and administration volume is 0.2mL/10g, continuous 10d.Simultaneously in addition to normal group, remaining each group animal is respectively in administration
Hydrocortisone parenteral solution (25mgkg/d), continuous 7d, to cause kidney-yin deficiency mouse is subcutaneously injected simultaneously.It is being administered respectively
It is forward and backward to weigh, calculate changes of weight difference.30min after last dose, autonomic activities sight is carried out to mouse with autonomic activities instrument
Examine, record in 10min and mouse autonomic activities number and probe into number, after give the copper wire of mouse tail heavy burden body weight 5%, allow mouse
In water temperature (25 ± 1) DEG C, depth of water 30cm swimming trunk went swimmings, observe and record mouse and exhaust the time that (power exhausts to power from putting into water
Standard is that the mouse 10s that sinks under water does not emerge, and righting reflex can not be carried out in plane after pulling out).Data withRepresent,
The conspicuousness of more each group difference of variance analysis is carried out using SPSS19.0 softwares, the results are shown in Table 7.
The present composition beverage of table 7 is to kidney-yin deficiency mouse weight growth rate, autonomic activities number, the influence for probing into number
(N=10)
Note：Compared with Kidney-yin-vacuity group, * P<0.05, * * P<0.01.
As seen from table, there is Body weight loss in Kidney-yin-vacuity group mouse after modeling, and activity is reduced, slow in reacting, etc. symptom,
Similar clinical kidney yin virtual state, show modeling success.Liuwei Dihuang Wan control group and each dosage group animal of the present composition
State is clearly better compared with model group.
(1) to the influence of mouse weight：Body weight significantly reduces compared with Normal group after modeling, after medication treatment, each treatment
Group body weight growth rate is above model control group.
(2) to mouse autonomic activities number, probe into the influence of number：Autonomic activities number after modeling, probe into number calibration
Normal control group significantly reduces；After medication treatment, each treatment group's autonomic activities number, probe into number pole and be significantly higher than model comparison
Group.
(3) time effects are exhausted to mice burden swimming power：Mouse Kidney swimming with a load attached to the body power exhausts the time compared with normal control after modeling
Group significantly reduces；After medication treatment, compared with model control group, each dosage group swimming with a load attached to the body power exhausts time pole and dramatically increased.
Show, each dosage group of the present composition to kidney-yin deficiency mouse weight, autonomous active number, probe into number, bear a heavy burden
Swimming power exhausts the time and had some improvement.
To sum up, present composition beverage group is respectively provided with antiinflammatory action.Diuretic test result shows, 10g/100ml is high,
In, low dose group total volume of urine increased, can pole dramatically increase urine volume, show that present composition beverage has preferable diuresis
Effect.Anti-fatigue test result shows, compared with blank group, each group mouse swimming time is longer than blank group；Wherein
10g/100ml and single Ma Kagao, middle dose group mouse swimming time extremely significantly extend, and low dose group mouse power exhausts swimming
Time significantly extends；And each dosage group swimming time of present composition beverage compared with single agate card corresponding dosage group
Extend.Show, present composition beverage has preferable antifatigue effect, and is better than single agate card extract solution.Kidney deficiency experiment knot
Fruit shows that each dosage group has necessarily to mice with kidney-yang deficiency body weight, adrenal gland, thymus gland, the weight saving of spleen gland and sexual glands atrophy
Improvement result；Each dosage group to kidney-yin deficiency mouse weight, autonomous active number, probe into number, swimming with a load attached to the body power exhausts the time has
Certain improvement result.And present composition beverage anti-inflammatory, diuresis, antifatigue and kidney tonifying functions are superior to the extraction of single agate card
Liquid.
Claims (6)
1. a kind of food, health products or pharmaceutical composition, it is characterised in that：Its bulk drug by following weight proportion component group
Into：
1 part of maca, 8.2 parts of radish juice, 0.8 part of honey.
2. food according to claim 1, health products or pharmaceutical composition, it is characterised in that：It is the water extraction by maca
Thing or/and ethanol extract, the oral formulations being prepared plus radish juice, honey, auxiliary material or complementary composition；The radish
Juice, it is made up of radish squeezing centrifuging and taking juice.
3. food according to claim 2, health products or pharmaceutical composition, it is characterised in that：The formulation is selected from particle
Agent, tablet, medicinal tea, oral liquid, capsule, pill.
4. composition described in claims 1 to 3 any one is preparing prevention or/and treatment kidney deficiency；Auxiliary treatment kidney deficiency, kidney tonifying
Strong essence, adjusts the purposes in the food, health products or medicine of hormone secretion.
5. composition described in claims 1 to 3 any one is preparing prevention or/and treatment prostatic disorders, urinary system togetherness
Purposes in the food of dye or sex dysfunction, health products or medicine.
6. composition described in claims 1 to 3 any one is preparing anti-inflammatory, diuresis or antifatigue food, health products or medicine
Purposes in product.
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| CN2014103130079 | 2014-07-02 | ||
| CN201510081824.0A CN104905244B (en) | 2014-07-02 | 2015-02-15 | A kind of kidney tonifying is smart by force, food, health products or the pharmaceutical composition of prevention or/and treatment prostatic disorders |
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| CN1690214A (en) * | 2004-04-19 | 2005-11-02 | 崔今淑 | Maca fermentation liquid and its preparing process |
| CN102138692B (en) * | 2011-01-21 | 2012-09-26 | 成都中医药大学 | Health-care drink and preparation method thereof |
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