CN101618087B - Health-care food with function of improving climacteric - Google Patents
Health-care food with function of improving climacteric Download PDFInfo
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Abstract
The invention discloses a health-care food with the function of improving climacteric, comprising the following active components according to parts by weight and the mixture ratio: 20-250 parts of spina date seed, 5-150 parts of senega, 5-150 parts of schisandra fruit, 5-150 parts of shelled cedar seed and 1-30 parts of wood frog oil. The health-care food has the characteristics that the feature of the traditional Chinese herbal medicine and the research of the modern medicine are combined, various components have reasonable combination and are matched to use together, and the health-care function of improving the climacteric is achieved by various approaches and a plurality of levels.
Description
Technical field
The present invention relates to a kind of health food, relate in particular to a kind of by Chinese herbal medicine be primary raw material make have the climacteric of an improvement health care foods.
Background technology
In July, 2006, united the portion finished shows at the investigation report result of women's health situation and problem by the Ou Jianong drugmaker of Holland and the Synovate health consultation company under the Synovate: at present, the climacteric women number of China occupies first place in the world, about 1.3 hundred million people, and the women more than 83% is suffering the puzzlement of climacteric phenomenon in various degree, especially the puzzlement of sleeping problems.And the climacteric women in China city just has 4,600 ten thousand more than (climacteric produce market: high-level integration is sought in marketing), the climacteric insomnia is very general, and along with increasingly sharpening of social competition's pressure, the work rhythm of life is accelerated, life style changes, insomnia more and more becomes a kind of " epidemic diseases " in the modern life, and insomnia also spreads in young working woman gradually with the vicious cycle of climacteric phenomenon, and the women's health situation is troubling.Actively improve the insomnia situation, improve sleep quality, but the not only involutional arrival of delaying female is also most important to promoting female life quality and quality of life.This is not only one of important topic of medical circle, also is the important component part that makes up harmonious family, harmonious society.
At present, external existing many moneys are used for improving sleep and the involutional health food of delaying female, as the health product such as treasured strong Shu Xin capsule, the super sheep placental extract of magnificent nation and Vitamin World Radix vernoniae asperae of the U.S., be its effect demand all to improve sleep, to alleviate Women.Chinese herbal medicine has special advantages aspect health care, have very high cognition degree in Chinese women, enjoys the favor of Chinese women.
Summary of the invention
The object of the present invention is to provide a kind of by Chinese herbal medicine be primary raw material make have the climacteric of an improvement health care foods, the various composition reasonable formula of this health food, cooperate shared, by number of ways, reach and improve involutional health food function at many levels.
Provided by the invention have improve the climacteric health care foods and be prepared from by the active component of following weight parts proportioning: Semen Ziziphi Spinosae 20～250, Radix Polygalae 5～150, Fructus Schisandrae Chinensis 5～150, Semen Platycladi 5～150, Oviductus Ranae 1～30.
Preferred weight part proportioning of the active component of preparation health food of the present invention is: Semen Ziziphi Spinosae 50～150, Radix Polygalae 10～50, Fructus Schisandrae Chinensis 10～50, Semen Platycladi 10～150, Oviductus Ranae 2～15.
Optimum weight part proportioning of the active component of preparation health food of the present invention is: Semen Ziziphi Spinosae 100, Radix Polygalae 30, Fructus Schisandrae Chinensis 30, Semen Platycladi 30, Oviductus Ranae 10.
Above-mentioned have the climacteric of an improvement health care foods, by common process, can make said multiple dosage form on the pharmaceutics, as capsule, tablet, powder or granule etc.
In the said components, the Semen Ziziphi Spinosae saponin in the Semen Ziziphi Spinosae is the functional component with tranquilizing effect, and effect is lasting, steady, has no side effect, and is a kind of composition of sleeping peacefully with unique effect mechanism.Animal experiment study shows that the medicine that has tranquilizing effect with majority is compared, and Semen Ziziphi Spinosae saponin does not disturb the learning and memory function of mice, and booster action is arranged on the contrary.Radix Polygalae bitter in the mouth suffering, slightly warm in nature is gone into the heart, kidney, lung meridian, and bitter in the mouth is gone into heart channel, the relieving restlessness that clears away heart-fire, acrid in the mouth is kind lead off sensible, gas and mind calming god happily, can lead to kidney qi and Fructus Alpiniae Oxyphyllae again, be restoring normal coordination between the heart and kidney, the Fructus Alpiniae Oxyphyllae of calming the nerves, the good merchantable brand that eliminates the phlegm and have one's ideas straightened out, normal and the use of Semen Ziziphi Spinosae compatibility.The Fructus Schisandrae Chinensis sour in the mouth is sweet warm in nature, returns lung, the heart, kidney channel, and Bearberry Extract is astringent or styptic treatment for spontaneous sweating, the effect of supplementing QI for promoting the production of body fluid, kidney calming, sour in the mouth can be restrained the motive, hidroschesis promotes the production of body fluid, sweet in the mouth can benefiting QI for strengthening the superficies hidroschesis, and kidney tonifying essence can be improved diseases such as fidgets due to deficiency cardiopalmus due to the heart kidney yin anemia void, insomnia and dreamful sleep.The Semen Platycladi sweet in the mouth is flat, goes into the heart, kidney, large intestine channel, the effect of tool tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Normal and Semen Ziziphi Spinosae compatibility are used to improve the caused restlessness of asrhenia type and insomnia of blood failing to tonify the heart, card such as the severe palpitation of palpitating with fear.Oviductus Ranae is the rare Chinese medicine that integrates medicine food health care, is rich in the multiple nutrients material, and the efficacy effect of its kidney invigorating and essence nourishing, nourishing lung-YIN can obviously improve the physiological situation of the hepatic and renal YIN deficiency, imbalance of YIN and YANG.
Health food of the present invention is selected Semen Ziziphi Spinosae and Semen Platycladi compatibility for use at lack of preservation of spirit, the blood tranquilizing mind that nourishes heart, and because of the Chinese is the liquid of the heart, and the merit of tool hidroschesis, with the Radix Polygalae compatibility, can play the effect of the kidney tonifying of calming the nerves; At caused by liver and kidney deficiency, select Oviductus Ranae and Fructus Schisandrae Chinensis for use, Oviductus Ranae has the effect of benefiting kidney-essence, be used to improve diseases such as insomnia cardiopalmus that the deficiency of YIN causes, hectic fever night sweat, compatibility Fructus Schisandrae Chinensis, tonification mind calming, controlling nocturnal emission with astringent drugs astringing YIN to stop sweating again, the compatibility Radix Polygalae then plays the effect of foster kidney yin, tranquilizing mind; So all medicines are assisted mutually, reach and improve sleep, endocrine regulation, the regulating yin and yang balance delays the health care purpose of climacteric phenomenon.
The characteristics of health food of the present invention are to be primary raw material with Semen Ziziphi Spinosae, Radix Polygalae, Fructus Schisandrae Chinensis, Semen Platycladi and five kinds of Chinese herbal medicine of Oviductus Ranae, make various composition reasonable formula, cooperate shared, by number of ways, reach and improve involutional health care at many levels.
The invention will be further described below by the specific embodiment and pharmacodynamic study result.
The specific embodiment
The present invention will be described to enumerate a part of specific embodiment below, is necessary to be pointed out that at this following specific embodiment only is used for that the invention will be further described, does not represent limiting the scope of the invention.Some nonessential modifications that other people make according to the present invention and adjustment still belong to protection scope of the present invention.
Embodiment 1
The embodiment of the invention 1 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 200, Radix Polygalae 120, Fructus Schisandrae Chinensis 100, Semen Platycladi 100, Oviductus Ranae 25.
Embodiment 2
The embodiment of the invention 2 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 200, Radix Polygalae 100, Fructus Schisandrae Chinensis 100, Semen Platycladi 20, Oviductus Ranae 2.
Embodiment 3
The embodiment of the invention 3 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 200, Radix Polygalae 50, Fructus Schisandrae Chinensis 20, Semen Platycladi 50, Oviductus Ranae 5.
Embodiment 4
The embodiment of the invention 4 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 50, Radix Polygalae 120, Fructus Schisandrae Chinensis 30, Semen Platycladi 20, Oviductus Ranae 10.
Embodiment 5
The embodiment of the invention 5 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 20, Radix Polygalae 30, Fructus Schisandrae Chinensis 120, Semen Platycladi 120, Oviductus Ranae 20.
Embodiment 6
The embodiment of the invention 6 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 100, Radix Polygalae 30, Fructus Schisandrae Chinensis 30, Semen Platycladi 30, Oviductus Ranae 10.
Embodiment 7
The embodiment of the invention 7 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 100, Radix Polygalae 30, Fructus Schisandrae Chinensis 50, Semen Platycladi 100, Oviductus Ranae 10.
Embodiment 8
The embodiment of the invention 8 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 80, Radix Polygalae 50, Fructus Schisandrae Chinensis 30, Semen Platycladi 100, Oviductus Ranae 15.
Embodiment 9
The embodiment of the invention 9 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 100, Radix Polygalae 50, Fructus Schisandrae Chinensis 20, Semen Platycladi 100, Oviductus Ranae 10.
Embodiment 10
The embodiment of the invention 10 provides has and improves the climacteric health care foods and be prepared from by the active component of following weight proportioning: Semen Ziziphi Spinosae 150, Radix Polygalae 30, Fructus Schisandrae Chinensis 50, Semen Platycladi 150, Oviductus Ranae 15.
Among the above embodiment, each component is the commercial goods, by common process, can make said multiple dosage form on the pharmaceutics, as capsule, tablet, powder or granule etc.
Pharmacodynamic study
The applicant is provided by the composition proportioning of the health food that is provided by the foregoing description 6, has the climacteric of improvement health care foods and has carried out the effect confirmatory experiment by common process is prepared, and experimental result is as follows:
1. experimental unit
Medicine Molecular Biology Lab of life sciences institute of Zhongshan University.
2. experiment purpose
Study health food of the present invention and have the function of the climacteric of improvement.
3. experiment material
3.1 experiment medicine
Health food of the present invention: improve climacteric sample (capsule), provide lot number by no thresold (China) company limited: 081007; Usage: each 1.2g, every day 2 times.
3.2 experiment reagent
Estradiol valerate tablet, faint yellow coated tablet, the accurate word J20080036 of traditional Chinese medicines; France DELPHARM LilleS.A.S company produces the packing of Bayer medicines and health protection company limited Guangzhou Branch, lot number: 081105; The medroxyprogesterone acetate sheet, the accurate word H44021696 of traditional Chinese medicines, Guangzhou Kanghe Pharmaceutical Co., Ltd. produces, lot number: 080301; The GENGNIANAN capsule, the accurate word Z22020683 of traditional Chinese medicines, Tonghua Jinhui Pharmaceutical Co., Ltd. produces, lot number: 070302.064.
3.3 detecting instrument:
The BS110S electronic balance, Beijing Sai Duolisi balance company limited is produced; OLYMPUS CX31 type microscope, Japanese OLYMPUS company produces; The BI2000 image processing system, Chengdu TME Technology Co., Ltd. produces;
3.4 laboratory animal
The SD rat: the SPF level, body weight 150-180g purchases in Guangdong Medical Lab Animal Center the quality certification: SCXK (Guangdong) the word 2008A020 that checks and affirm in 2003-0002 Guangdong.
3.6 raising condition
SPF level SD rat feeding is in Zhongshan University's school of life and health sciences Chinese medicine and marine drug laboratory SPF level laboratory animal room, the zoopery environmental facility quality certification number: GB14925-2001, and the Guangdong word 2004C009 that checks and affirm, check and affirm word 2004C009 number in Guangdong.25 ± 1 ℃ of indoor maintenances are freely drunk water, are taken food, and adopt 12h: 12h to be interrupted illumination round the clock, change water weekly 3 times, change bedding and padding 2 times, water material abundance, and SPF level feedstuff originates from Guangdong Medical Lab Animal Center.
3.7 experimental result statistical procedures
Experimental data adopts Microsoft Excel 2003 to carry out statistical procedures, and the result represents with x ± s, and carries out TTEST and analyze the significance of t value method comparable group differences.
4. experimental technique and result
4.1 experimental technique
4.1.1 test dose setting
Table 1 dosage
| Group | Be equivalent to the multiple of being grown up | Rat dosage (mg/kg) |
| Improve climacteric sample low dosage | 5 | 158.3 |
| Improve dosage in the climacteric sample | 10 | 316.7 |
| Improve climacteric sample high dose | 30 | 950 |
| The GENGNIANAN capsule | 30 | 1044 |
| Estradiol valerate tablet medroxyprogesterone acetate sheet Annotate | 10 10 | 0.089 0.714 |
| Sham operated rats | - | The equal-volume distilled water |
| Model control group | - | The equal-volume distilled water |
Annotate: it is 0.089mg/kg that estradiol valerate tablet administration in every month 22 days, rat give dosage; Medroxyprogesterone acetate sheet every month was from the 17th day successive administration of estradiol administration 5 days.
4.1.2 experimental procedure
Choose 70 of healthy SD female rats, body weight 150-180g quarantined behind the animal about a week, carried out modeling and handled.Rat is through lumbar injection chloral hydrate 10%, press the anesthesia of 0.3g/kg body weight, fixing back, abdomen position in ventrimeson apart from vaginal orifice 3-4cm place unhairing, use iodine tincture and alcohol disinfecting respectively, treat dried slightly back incision skin and the about 2-3cm of abdominal muscle, the visible white adipose in the otch visual field, after pushing fat deposit aside and finding the uterus, gently a side cornua uteri is pulled out the ovary that is as seen wrapped up at its end by liparitosis. fractionation of fatty group, just can see the ovary of pink or yellowish red color.Clamp ovary with mosquito forceps, then fallopian tube under the ovary (comprising fat) is used the silk thread ligation, wipe out ovary (check and whether wipe out fully), take advantage of a situation cornua uteri is sent back in the abdominal cavity. wipe out other side ovary with method.After abdominal muscle and skin layering are sewed up, sterilization once more.After hindlimb muscle injection 20000U/kg penicillin, antibiotics was handled 3 days continuously.Behind the removal ovary 3 days, rat is divided into 7 groups at random, be respectively Sham-operated control group, model control group, parallel control group, GENGNIANAN capsule matched group, hormone matched group and improve the basic, normal, high dosage group of climacteric sample, every group of 10 rats, respectively each group rat is weighed, number, and carry out administration by the dosage table.
Rat is write down body weight weekly once, and adjusts dosage by the body weight value; The average food ration of record rat, this model test time is about 90 days.
When experiment finishes, take by weighing rat body weight, it is clear respectively to organize rat extracting blood then, frozen centrifugation, and-20 ℃ of preservations are with radioimmunity kit measurement serum estradiol (E
2), progesterone (P), estrone (E
1), the content of follicule-stimulating hormone (FSH) (FSH), lutropin (LH), rat takes off cervical vertebra and puts to death separating uterus, left and right sides adrenal gland, thymus, spleen, absorbent paper is blotted, and weighs, and calculates each organ index, more than each index all carry out statistical procedures, comparable group differences.
4.2 observation index
4.2.1 to the hormone index of removal ovary rat and the experimental result of organ coefficient
The experimental result of the organ coefficient of table 2 pair removal ovary rat (x ± SD, n=10)
| Group | Body weight after the administration (g) | Uterus index (mg/100g) | Index and spleen index (mg/100g) | Thymus index (mg/100g) | Adrenal gland's index (mg/100g) |
| Sham operated rats | 309.1±21.4** | 258.±127.3*** | 217.6±52.1* | 99.2±26.7 | 9.4±1.6* |
| Model control group | 341.0±17.9 | 30.9±9.8 | 168.2±31.2 | 117.0±22.3 | 7.7±1.2 |
| Improve climacteric sample low dose group | 329.2±32.5 | 27.4±5.1 | 183.7±23.9 | 120.1±23.3 | 6.8±1.1 |
| Improve dosage group in the climacteric sample | 313.9±29.5* | 31.1±9.0** | 196.6±51.2 | 120.7±25.4 | 6.5±1.3 |
| Improve climacteric sample high dose group | 323.8±33.4 | 53.7±11.7*** | 195.8±51.6 | 117.6±21.1 | 7.2±1.4 |
| The GENGNIANAN Capsules group | 324.2±27.7 | 30.5±8.5 | 210.9±40.5 | 106.1±22.7 | 7.9±1.5 |
| The hormone matched group | 303.5±21.1*** | 75.3±15.4*** | 229.7±33.0*** | 103.5±22.6 | 8.7±1.6 |
Annotate: with the model control group comparison same period
*P＜0.05,
*P＜0.01,
* *P＜0.001.
4.2.2 experimental result to the food ration of removal ovary rat
The experimental result of the food ration of table 3 pair removal ovary rat (unit: g//day)
4.2.3 experimental result to the hormone index of removal ovary rat
The experimental result of the hormone index of table 4 pair removal ovary rat (x ± SD, n=10)
| Group | Estradiol (pg/ml) | Progesterone (ng/ml) | Estrone (pg/ml) | Follicule-stimulating hormone (FSH) (mIU/ml) | Lutropin (mIU/ml) |
| Sham operated rats | 3.868±1.758*** | 32.465±16.006*** | 48.33±20.97** | 4.037±1.653*** | 2.121±0.871*** |
| Model group | 0.768±0.196 | 0.463±0.392 | 22.41±13.40 | 7.631±2.242 | 4.594±0.885 |
| Improve climacteric sample low dose group | 1.167±0.637 | 1.369±0.753** | 41.63±13.04** | 6.586±2.356 | 3.318±1.136* |
| Improve dosage group in the climacteric sample | 1.468±0.536*** | 2.443±0.921*** | 45.04±17.67** | 5.999±2.659 | 2.711±0.773*** |
| Improve climacteric sample high dose group | 2.765±0.855*** | 2.731±0.875*** | 49.18±12.82*** | 5.874±2.531 | 2.523±1.122*** |
| Parallel group | 1.646±0.660** | 1.400±0.547*** | 45.27±11.91*** | 5.739±1.302* | 1.634±1.104*** |
| The GENGNIANAN group | 4.361±3.813** | 1.663±1.096** | 38.42±6.59** | 5.533±1.866* | 1.106±0.916*** |
| The hormone group | 2.232±0.981*** | 5.283±4.008** | 43.77±7.38*** | 4.905±0.951** | 1.274±0.855*** |
Annotate: with the model control group comparison same period
*P＜0.05,
*P＜0.01,
* *P＜0.001.
4.3 experimental result
Can get by table 2 experimental result, rat excision ovary and administration are after about 90 days, the body weight of model control group rat obviously increases, index and spleen index, adrenal gland's index obviously reduce than sham operated rats, the These parameters sham operated rats is compared with model control group, has significant difference (P＜0.05, P＜0.01); Cut open the obvious atrophy in uterus of the visible model control group rat of inspection, uterus index sham operated rats is compared with model control group, has significant difference (P＜0.001), prompting modeling success.The body weight of improving climacteric group rat presents downward trend along with the increase of dosage, and with the same period model control group compare, have significant difference (P＜0.05); The uterus index that improves climacteric group rat increases along with the increase of dosage, wherein the uterus index of high dose group rat with the same period model control group compare, have significant difference (P＜0.05, P＜0.001).Tentatively prompting improves the climacteric high dose group and can significantly improve the metratrophia of removal ovary rat thus, and it may have certain hormonal regulation effect;
Can get by table 3 experimental result, the food ration of model group and sham operated rats rat is basicly stable, food ration of each administration group rat and model group fluctuate in certain scope but are approaching substantially, during the administration 3 months, do not see the food ration generation obvious variation of model group and administration group rat, point out given the test agent less thus the food ration influence of rat.
Can get by table 4 biochemical indicator testing result, the excision ovary of model control group rat is after 3 months, serum hormone generation significant change, estradiol wherein, estrone, progesterone obviously descends, flitropin and interstitialcellstimulating hormone (ICSH) then obviously raise, with the same period sham operated rats compare, has significant difference (P＜0.01, P＜0.001), the prompting rat is because after losing ovary and all compensations and exhausting, body inner estrogen and progesterone level present reduction significantly, and after lacking estrogenic negative feedback, the amount of hypophysis secretion interstitialcellstimulating hormone (ICSH) obviously raises, and illustrates that the model of removal ovary rat simulation Woman climacteric prepares the condition that has reached menopausal women successfully and.Middle and high each the dosage group rat blood serum estradiol and the estrone content that improve the climacteric prescription obviously raise, with the same period model control group compare, have significant difference (P＜0.05, P＜0.01, P＜0.001); The serum progesterone index of improving basic, normal, high three dosage group rats of climacteric sample obviously raises, with the same period model control group compare tool significant difference (P＜0.01, P＜0.001); The content that improves involutional serum interstitialcellstimulating hormone (ICSH) obviously reduces, with the same period model control group compare, have significant difference (P＜0.05, P＜0.01, P＜0.001).
5. brief summary
This experimental result shows that health food of the present invention has the climacteric of improvement health function.
Claims (4)
1. one kind has the climacteric of improvement health care foods, it is characterized in that the active component of this health food and weight portion proportioning thereof are: Semen Ziziphi Spinosae 20～250, Radix Polygalae 5～150, Fructus Schisandrae Chinensis 5～150, Semen Platycladi 5～150, Oviductus Ranae 1～30.
2. according to claim 1 have the climacteric of an improvement health care foods, and wherein the weight portion proportioning of each active component is: Semen Ziziphi Spinosae 50～150, Radix Polygalae 10～50, Fructus Schisandrae Chinensis 10～50, Semen Platycladi 10～150, Oviductus Ranae 2～15.
3. according to claim 1 have the climacteric of an improvement health care foods, and wherein the weight portion proportioning of each active component is: Semen Ziziphi Spinosae 100, Radix Polygalae 30, Fructus Schisandrae Chinensis 30, Semen Platycladi 30, Oviductus Ranae 10.
4. describedly have the climacteric of an improvement health care foods according to claim 1,2 or 3, the dosage form that it is characterized in that described health food is capsule, tablet, powder or granule.
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| CN102669659A (en) * | 2012-04-27 | 2012-09-19 | 无限极（中国）有限公司 | Health-care food with sleep improving function |
| CN103251793B (en) * | 2012-12-27 | 2015-04-15 | 北京中研同仁堂医药研发有限公司 | Pharmaceutical composition for improving climacteric symptoms and preparation method of pharmaceutical composition |
| CN103495054B (en) * | 2013-09-25 | 2014-09-03 | 牛艳红 | Traditional Chinese medicine preparation for treating climacteric syndrome and preparation method thereof |
| CN104888176A (en) * | 2015-06-29 | 2015-09-09 | 孙小荣 | Spleen deficiency type climacteric syndrome treatment traditional Chinese medicine |
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| CN1911255A (en) * | 2006-08-17 | 2007-02-14 | 李晔 | Anti-oxidation tech. for wall-breaked glossy ganoderma spore powder |
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