CN104887282B - A kind of vascular repair device - Google Patents
A kind of vascular repair device Download PDFInfo
- Publication number
- CN104887282B CN104887282B CN201510270563.7A CN201510270563A CN104887282B CN 104887282 B CN104887282 B CN 104887282B CN 201510270563 A CN201510270563 A CN 201510270563A CN 104887282 B CN104887282 B CN 104887282B
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- China
- Prior art keywords
- circular support
- support shell
- spinneret orifice
- repair device
- vascular repair
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- 230000002792 vascular Effects 0.000 title claims abstract description 26
- 239000012530 fluid Substances 0.000 claims abstract description 41
- 239000007921 spray Substances 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 5
- 210000004204 blood vessel Anatomy 0.000 description 9
- 230000001070 adhesive effect Effects 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 5
- 239000000835 fiber Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 239000003364 biologic glue Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000007767 bonding agent Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000010711 Cattle disease Diseases 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- AFVLVVWMAFSXCK-VMPITWQZSA-N alpha-cyano-4-hydroxycinnamic acid Chemical group OC(=O)C(\C#N)=C\C1=CC=C(O)C=C1 AFVLVVWMAFSXCK-VMPITWQZSA-N 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001497 fibrovascular Effects 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002186 photoactivation Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
- A61B2017/00522—Sprayers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00831—Material properties
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Surgical Instruments (AREA)
Abstract
The present invention relates to a kind of vascular repair device, including circular support shell, the side of described circular support shell is connected with external fluid passage；Described circular support enclosure is provided with internal fluid channels；Described internal fluid channels are connected with external fluid passage, and are provided with flow direction controlling switch in junction；It is provided with high-voltage conducting wires in described external fluid passage and internal fluid channels；Also spinneret orifice is distributed with described circular support shell, is connected with internal fluid channels and high-tension line inside described spinneret orifice, spinneret orifice lateral direction is directed to the center of described circular support shell.The present invention may replace various numerous and diverse operations in existing internal medicine vascular suture mending course, reduces surgical error rate.
Description
Technical field
The present invention relates to vascular repair technical field, more particularly to a kind of vascular repair device.
Background technology
Vascular repair is the basis of organ transplantation in modern medicine, is also the important part of surgical operation.Operation stitching
It is the most important means of current vascular repair with medical adhesive.
The means of traditional vascular repair are operation stitchings, and from modern medicine is born so far, operation stitching occupies always
The major part of vascular repair, perfect operation stitching blood vessel requires blood vessel not oozing of blood, can complete at short notice, can
Any rupture will not be produced before blood vessel selfreparing.So, operation stitching is very strong to the technology dependence of doctor, and contrast is larger
The blood vessel of bore carries out operation stitching and is comparatively easier, but just relatively difficult for the suture of fibrovascular.Handss
The fault rate raising of art leads to patient's repeat surgery or death.
Development with tissue engineering technique and rise, large quantities of macromolecular materials especially biological adhesive is expected to be answered
Use vascular suture technology.Ideal biological binding agent has to meet some clinical requirements：
(1) safe and reliable, avirulence, no three cause (carcinogenic, teratogenesis, mutagenesis)；
(2) there is good biocompatibility, itself healing of without prejudice to tissue；
(3) aseptic and can keep aseptic over a period to come；
(4) can use under conditions of having blood and tissue fluid；
(5) quick-binding can be realized under room temperature, normal pressure；
(6) there is good bonding strength and persistency, stick portion has certain elasticity and toughness；
(7) in use to tissue nonirritant；
(8) can gradually degrade after reaching using effect, absorb, metabolism；
(9) there is good use state and be easy to preserve.
Disclosure satisfy that the biological adhesive of above-mentioned all conditions have not been reported.
The existing medical adhesive being commercialized mainly includes fibrin glue, collagen protein bonding agent, alpha-cyano
Esters of acrylic acid adhesive, Polyethylene Glycol (PEG) polymer etc., but these materials undoubtedly there is also this some unsatisfactory lacking
Point, such as fibrin glue commercial production be difficult problem it is necessary to by strict plasma screening, inactivation of virus, in case
The only potential threat of infective virus, and must low temperature storage, using front needing to melt, product adhesion strength low it is impossible to for height
Intensity requirement position；Collagen protein bonding agent due to employing thrombin of beef and bovine collagen albumen, increased immunological diseases (as crazy
Cattle disease) risk.A-cyanoacrylate class adhesive can be polymerized after meeting water immediately, can make troubles to operation.Glue-line fragility
Greatly, it is not suitable with peripheral organs' flexible tissue.And preserve inconvenience, easily occur rotten in wet environment.Burst pressure is little, to some
High-tension wound adhesive effect is poor.Catabolite can produce formaldehyde, can cause acute or chronic inflammation, tissue necrosiss and potential
Carcinogenecity, therefore cannot be used for in-vivo tissue bonding.Polyethylene glycol hydrogel can serve as tissue adhension.FocalSeal—L
(Genyzme Biosurgey, Inc., Britain) is a kind of water miscible bioabsorbable compound.It needs the plenty of time
Carry out photoactivation, thus limit it and be applied to adhesive field of stopping blooding.
So far, except this biopolymer having particular/special requirement to material of biological adhesive have trial be used to into
Row vascular repair, much by the tissue engineering material of FDA certification because not having suitable method to repair without being applied to blood vessel
Multiple.
Content of the invention
The technical problem to be solved is to provide a kind of vascular repair device, may replace existing internal medicine vascular suture
Various numerous and diverse operations in mending course, reduce surgical error rate.
The technical solution adopted for the present invention to solve the technical problems is：There is provided a kind of vascular repair device, including circular
Support housing, the side of described circular support shell is connected with external fluid passage；In described circular support enclosure is provided with
Portion fluid passage；Described internal fluid channels are connected with external fluid passage, and junction be provided with flow direction control open
Close；It is provided with high-voltage conducting wires in described external fluid passage and internal fluid channels；Spray is also distributed with described circular support shell
Silk hole, is connected with internal fluid channels and high-tension line inside described spinneret orifice, spinneret orifice lateral direction is directed to described circle
The center of shape support housing.
The opposite side of the side that described circular support shell is provided with external fluid passage is provided with open channel.
Described spinneret orifice has six, and is evenly distributed on circular support shell.
Described spinneret orifice is waist-drum-shaped spinneret orifice.
Described waist-drum-shaped spinneret orifice is made using conductive metal.
It is provided with conductive pattern layer and the conductive slider being connected with described spinneret orifice in described flow direction controlling switch, described lead
Below the internally positioned fluid passage of electrograph layer, when flow direction controlling switch remains operationally, only flow of fluid
The circuit of side is connection.
Beneficial effect
Due to employing above-mentioned technical scheme, the present invention compared with prior art, has the following advantages that and actively imitates
Really：Fiber uniformly can be taped against the port disconnecting blood vessel by the present invention, and through repetition several times, fiber is by intact to blood
Pipe port carries out coated, incision position realization reparation the most at last.The present invention is simple and practical, and solve to run in vascular suture various asks
Topic, may replace various numerous and diverse operations in existing internal medicine vascular suture mending course, reduces surgical error rate, solves blood vessel seam
Close the dependence that art operates level to doctor, improve efficiency and the quality of vascular suture.
Brief description
Fig. 1 is the structural representation of the present invention；
Fig. 2 is the structural representation of spinneret orifice in the present invention；
Fig. 3 is the structural representation of flow direction controlling switch in the present invention.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than restriction the scope of the present invention.In addition, it is to be understood that after having read the content of present invention instruction, people in the art
Member can make various changes or modifications to the present invention, and these equivalent form of values equally fall within the application appended claims and limited
Scope.
Embodiments of the present invention are related to a kind of vascular repair device, as shown in figure 1, including circular support shell 1, described
The side of circular support shell 1 is connected with external fluid passage 2, and described circular support shell 1 is provided with the one of external fluid passage 2
The opposite side of side is provided with open channel；It is provided with internal fluid channels 3 inside described circular support shell 1；Described internal flow leads to
Road 3 is connected with external fluid passage 2, and is provided with flow direction controlling switch 4 in junction；Described external fluid passage 2 He
It is provided with high-voltage conducting wires 5 in internal fluid channels 3；Six spinneret orifices 6 are also evenly distributed with described circular support shell 1, described
Spinneret orifice 6 inner side is connected with internal fluid channels 3 and high-voltage conducting wires 5, and spinneret orifice 6 lateral direction is directed to described circular support
The center of shell 1.As shown in Fig. 2 described spinneret orifice 6 is waist-drum-shaped spinneret orifice, described waist-drum-shaped spinneret orifice adopts can be conductive
Metal make.As shown in figure 3, being provided with conductive pattern layer 41 in described flow direction controlling switch 4 and being connected with described spinneret orifice 6
Conductive slider 42, below the internally positioned fluid passage 3 of described conductive pattern layer 41, when flow direction controlling switch remains at
During work, the circuit of the only side of flow of fluid is connection.
Operation principle of the present invention is as follows：
Six waist-drum-shaped spinneret orifices are evenly distributed on circular support shell, with fluid passage and high-tension line inside spinneret orifice
It is connected, spinneret orifice lateral direction is directed to circular support center, and spin fluid is in the case of certain pressure through external fluid
Passage and internal fluid channels are transported to and extrude at the waist-drum-shaped spinneret orifice of circular support shell side, add certain value simultaneously
High pressure, polymer solution is spun into fiber under certain extruded velocity and high voltage and uniformly sprays to circular support shell
Between, rotating fluid direction control switch, fluid uniformly sprays from the waist-drum-shaped spinneret orifice of circular support shell opposite side, is sprayed onto circle
The center of shape support housing.
The blood vessel that open channel on described circular support shell is available for two disconnections is put into, and fiber is uniformly taped against two
The port that root blood vessel disconnects, through the repetition of 2-3 time, fiber carries out coated, fracture the most at last by intact to vascular ports
Place realizes repairing.
Claims (6)
1. a kind of vascular repair device, including circular support shell (1) it is characterised in that the one of described circular support shell (1)
Side is connected with external fluid passage (2)；It is provided with internal fluid channels (3) inside described circular support shell (1)；Described internal stream
Body passage (3) is connected with external fluid passage (2), and is provided with flow direction controlling switch (4) in junction；Described outside stream
It is provided with high-voltage conducting wires (5) in body passage (2) and internal fluid channels (3)；Spray webbing is also distributed with described circular support shell (1)
Hole (6), is connected with internal fluid channels (3) and high-voltage conducting wires (5) inside described spinneret orifice (6), spinneret orifice (6) lateral direction
It is directed to the center of described circular support shell (1).
2. vascular repair device according to claim 1 is it is characterised in that described circular support shell (1) is provided with outside
The opposite side of the side of fluid passage (2) is provided with open channel.
3. vascular repair device according to claim 1 is it is characterised in that described spinneret orifice (6) has six, and uniformly divides
Cloth is on circular support shell (1).
4. vascular repair device according to claim 1 is it is characterised in that described spinneret orifice (6) is waist-drum-shaped spinneret orifice.
5. vascular repair device according to claim 4 is it is characterised in that described waist-drum-shaped spinneret orifice is using conductive
Metal is made.
6. vascular repair device according to claim 1 is it is characterised in that set in described flow direction controlling switch (4)
There are conductive pattern layer (41) and the conductive slider (42) being connected with described spinneret orifice (6)；The internally positioned fluid of described conductive pattern layer leads to
Below road (3)；When flow direction controlling switch (4) remains operationally, the circuit of the only side of flow of fluid is even
Logical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510270563.7A CN104887282B (en) | 2015-05-25 | 2015-05-25 | A kind of vascular repair device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510270563.7A CN104887282B (en) | 2015-05-25 | 2015-05-25 | A kind of vascular repair device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104887282A CN104887282A (en) | 2015-09-09 |
| CN104887282B true CN104887282B (en) | 2017-03-08 |
Family
ID=54020553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510270563.7A Active CN104887282B (en) | 2015-05-25 | 2015-05-25 | A kind of vascular repair device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104887282B (en) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE473082T1 (en) * | 2001-03-20 | 2010-07-15 | Nicast Ltd | PORTABLE ELECTROSPINNER DEVICE |
| US7134857B2 (en) * | 2004-04-08 | 2006-11-14 | Research Triangle Institute | Electrospinning of fibers using a rotatable spray head |
| CN1947664A (en) * | 2006-10-17 | 2007-04-18 | 南京大学 | Means used for blood vessel prosthesis and reconstruction |
| US7799261B2 (en) * | 2007-11-30 | 2010-09-21 | Cook Incorporated | Needle-to-needle electrospinning |
| DE102008034183A1 (en) * | 2008-07-17 | 2010-01-21 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Device and method for applying a coating on a lateral surface of a medical hollow body |
| CN102776583B (en) * | 2012-07-04 | 2014-11-12 | 青岛大学 | Portable handheld electrostatic spinning device |
| CN103114347B (en) * | 2013-03-08 | 2015-03-11 | 厦门大学 | Continuous fiber-manufacturing device |
| CN103343393B (en) * | 2013-07-24 | 2016-01-20 | 苏州大学 | A kind of electrostatic spinning apparatus of three-dimensional manometer fibre assemblies and method |
| CN103526336A (en) * | 2013-10-15 | 2014-01-22 | 东华大学 | Preparation method of oriented shell-core structural superfine composite fiber |
| CN203583028U (en) * | 2013-12-05 | 2014-05-07 | 厦门大学 | Device for manufacturing nanofibers |
| CN203976986U (en) * | 2014-07-02 | 2014-12-03 | 北京化工大学 | A kind of combination electrostatic spinning apparatus of preparing multistage superfine fibre |
| CN104451912A (en) * | 2014-11-24 | 2015-03-25 | 浙江大学 | Preparing device and method for forming micro-nanofiber |
-
2015
- 2015-05-25 CN CN201510270563.7A patent/CN104887282B/en active Active
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|---|---|
| CN104887282A (en) | 2015-09-09 |
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