CN209450597U - The plugging device of intracranial aneurysm - Google Patents

The plugging device of intracranial aneurysm Download PDF

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Publication number
CN209450597U
CN209450597U CN201821298904.7U CN201821298904U CN209450597U CN 209450597 U CN209450597 U CN 209450597U CN 201821298904 U CN201821298904 U CN 201821298904U CN 209450597 U CN209450597 U CN 209450597U
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plugging device
proximal end
aneurysm
developing mark
fixed
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CN201821298904.7U
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向勇刚
万杰清
张吉勇
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Shanghai Weimi Medical Technology Co Ltd
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Shanghai Weimi Medical Technology Co Ltd
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Abstract

The utility model relates to a kind of plugging device of intracranial aneurysm, the plugging device includes plugging device ontology, developing mark, delivery guidewire, burble point, delivery pipe, separator, and the developing mark is separately fixed at plugging device ontology proximally and distally;The plugging device is reticulated by 24-72 bursts of Ultimum Ti silk braidings;Distal end is respectively provided with developing mark with proximal end after the plugging device opens completely, and respectively beam holds together the Ultimum Ti silk of fixed plugging device distal end and proximal end to developing mark;The delivery guidewire is located in delivery pipe;Plugging device proximal end developing mark and delivery guidewire distal end are intermediate equipped with burble point;The delivery guidewire proximal end is connected with separator.In the case where not opening cranium, type up-narrow and down-wide for encephalic, giant aneurysm type, branch type aneurysm, by being implanted into plugging device ontology, the plugging device stable structure, the fast densified filling tumor chamber of energy after expansion reduces blood to the surge of tumor chamber to slow down flowing of the blood in aneurysm cavity, reinforce repair ability, reaches the aneurysmal purpose for the treatment of.

Description

The plugging device of intracranial aneurysm
Technical field
The utility model patent is related to a kind of Minimally Interventional Therapy device, belongs to the field of medical instrument technology, more particularly to A kind of device carrying out intracranial aneurysm closure by minimally invasive intervention means.
Background technique
According to Chinese cerebrovascular disease guideline of prevention and treatment, recently as the fast development of Chinese national economy, the substance of people Living standard is also greatly improved, and seriously affects diet and regularity in one's life, and the population that simultaneous arrives rapidly is old Age process, at present cerebrovascular related disease have become influence China middle-aged and the old health and life-threatening safety it is main One of disease.
About 2,000,000 people of patient of national annual new hair stroke (containing hemorrhagic apoplexy and Ischemic Stroke);Brain is died of every year About 1,500,000 people of the patient of relevant vascular diseases;Patient's number (including disabled patient and cured person) 600~7,000,000 of survival.Brain Relevant vascular diseases cause patient disabilities' ratio very high, according to statistics, in the cerebrovascular related disorder patients of survival, about four / tri- or so patient disability or self care ability to some extent, wherein there are about 40% patients due to brain Vascular diseases cause severe to disable.Currently, the whole nation every year will be 100 for treating the health care expenditures estimation of cranial vascular disease Hundred million yuan or more, in addition various indirect economic losses, estimation is every year because the total expenditure of cranial vascular disease is close to 20,000,000,000 yuan of people Coin causes heavy financial burden to country and numerous patient homes.
In cerebrovascular disease, intracranial aneurysm incidence is tightly inferior to cerebral thrombosis, occur with hypertension, cerebral arteriovenous malformation, Infection, wound etc. are related, are apt to occur in the 40-60 years old middle-aged and the old.Caused subarachnoid hemorrhage after rupture of intracranial aneurysm is Lead to a kind of disease that the death rate is high-incidence.
Traditional treatment of intracranial aneurysm means include that 1) surgical operation therapy is such as: aneurysm clip occlusion, aneurysm neck knot Prick art, incision suture of giant aneurysm etc.;2) internal medicine treatment, traditional internal medicine treatment is commonly used in uncracked Stable type aneurysm, main purpose are to control those by drug to induce the latent dangerous factor of aneurysm rupture, are such as controlled Patients' blood processed etc.;3) Minimally Interventional Therapy is such as: spring ring clogs aneurysm cavity, liquid glue filling aneurysm cavity and bracket Auxiliary filling etc..
Haemodynamics plays an important role in the generating process of intracranial aneurysm to the influence factor of intracranial vessel.It grinds Study carefully and show: when blood flows in the blood vessel, several different active forces being generated to vascular wall, mainly there is shear stress, pulsating force And pressure.The continuous action power of blood easily causes elastic layer in cerebral artery vessel crotch and damages, and is usually associated with blood Pipe middle layer defect expands, so bump of the intracranial vessel in bifurcation by blood flow, is easy to happen endangium damage And local bulkiness protrusion is generated under blood stream pressure, finally gradually form aneurysm.
The microlesion on entocranial artery vascular bifurcation position top caused by blood flow impacts is formed with centainly with aneurysmal Correlation.Since blood is viscous liquid, it is that (blood is small for blood main component that normal blood viscosity, which is 5.45-6.35mpa/ seconds, Plate, red blood cell, leucocyte and blood plasma etc.) flow deformation and ability of aggregation general performance.The blood flow of viscosity is sustainable right The vascular wall of bifurcation generates axial shear stress, and blood flow velocity is faster, and the shear stress which is subject to is bigger, when When shear stress is increased to a certain extent, causes endarterium impaired or tearing and gradually form aneurysm.Arterial vascular point It is often therefore the main function point of blood flow impact is easiest to that entocranial artery occurs at bifurcated artery knuckle at fork distal side knuckle Tumor;And the angle of bifurcated is bigger, causes impact force suffered by crotch distal vessels wall bigger, is more likely formed aneurysm.And Aneurysm is once occur, and arteries form also generates change (protrusion, local bulkiness etc.), so as to cause the blood flow of intracranial vessel Dynamics also occurs accordingly to change.
First entered after intracranial aneurysm is formed, when arterial vascular blood flow passes through aneurysm with a thinner inflow road dynamic The distal site of arteries and veins tumor neck causes directly to impact to aneurysmal distal exterior wall, while blood flow velocity slows down;Then, pass through The blood flow of aneurysm distal exterior wall is flowed with slower speed along aneurysm inner wall, gradually forms vortex;Finally, formed The blood flow of vortex is flowed out through tumor neck proximal end.
Based on principle of hemodynamics, Chinese invention patent application number 201210278884.8 discloses a kind of cerebral aneurysm Support system and preparation method thereof is completely cut off aneurysm by overlay film frame and inner support bracket, thus prevent aneurysm rupture, Reduce Parent artery occlusion.But since the technology completely cuts off intracranial aneurysm by being covered with macromolecule membrane in rack surface, It is higher for bracket release request in actual clinical use, since the inaccuracy of positioning may cause bracket covering branch vessel The case where occur, so as to cause postoperative cerebral apoplexy complication;Simultaneously because using double branch of overlay film frame and inner support bracket Frame technology causes transportation system flexibility inadequate, and the ability by the tortuous vascular lesion of encephalic is limited, so that limiting it makes With.
It is equally based on principle of hemodynamics, Chinese invention patent application number 200810202854.2 discloses one kind and is used for The intravascular stent of lesion vessels repairing uses mesh porosity to design for 55%~75% Ultimum Ti mesh grid, will The intravascular stent is implanted into lesion vessels, after discharging the bracket at aneurysm neck, since highdensity metal mesh is at tumor neck Barrier effect is formed, the blood flow in tumor is slowed down, to realize the repairing reconstruct of blood vessel.The highdensity intravascular stent design, It is aneurysmal to play the role for the treatment of, but since the metal wire material of braiding structure is embedded in normal parent artery, and cover The normal blood vessels of part are covered, patient generally requires to take anticoagulant all the life, the thrombosis being just avoided that in normal blood vessels; The close net support system of the invention is needing one section of stabilization just in order to maintain the stabilization of bracket in the blood vessels, in aneurysm diseased region Fixed section of the normal blood vessel as bracket, which limit the clinical applications of the product.
In conclusion type up-narrow and down-wide for encephalic, epimegetic aneurysm and the artery at bifurcated vessels position at present Tumor, there are no the processing of suitable means, clinically need a kind of aneurysmal product of novel Minimally Interventional Therapy, the plugging device Stable structure, the fast densified filling tumor chamber of energy after expansion reduce blood to tumor to slow down flowing of the blood in aneurysm cavity The surge of chamber reinforces repair ability, reaches the aneurysmal purpose for the treatment of.
Summary of the invention
The utility model proposes a kind of aneurysmal plugging devices of novel encephalic.
The purpose of this utility model is standard to type up-narrow and down-wide for encephalic at present, epimegetic, bifurcated vessels type position Aneurysm provides a kind of a kind of novel Minimally Interventional Therapy aneurysm product of fast densified filling tumor chamber of energy, the plugging device Stable structure, the fast densified filling tumor chamber of energy after expansion reduce blood to tumor to slow down flowing of the blood in aneurysm cavity The surge of chamber reinforces repair ability, reaches the aneurysmal purpose for the treatment of.
The plugging device of the intracranial aneurysm includes plugging device ontology, plugging device proximal end developing mark, blocks dress Set distal end developing mark, delivery guidewire, burble point, delivery pipe, separator, plugging device proximal end developing mark and the envelope Block apparatus distal end developing mark is separately fixed at the plugging device ontology proximally and distally;The plugging device ontology by 24-72 bursts of Ultimum Ti silk braidings reticulate;Distal end is respectively provided with development mark with proximal end after the plugging device opens completely Note, and respectively beam holds together the Ultimum Ti silk of fixed plugging device body distal end and proximal end to developing mark;The delivery guidewire In delivery pipe;Plugging device proximal end developing mark and delivery guidewire distal end are intermediate equipped with burble point;The conveying is led Silk proximal end is connected with separator.
The plugging device separates plugging device ontology and delivery guidewire by burble point.
The plugging device disconnects burble point by separator.
The plugging device is in " cylinder ", and top and bottom are in indent " cone ".
The developing mark built-in height of proximal end and distal end must not exceed the plugging device sheet in the plugging device ontology The top and bottom of body.
The plugging device determines plugging device by the developing mark of the proximal end of plugging device body apparatus and distal end The position in parent artery.
Plugging device type up-narrow and down-wide for encephalic, giant aneurysm type, branch type aneurysm are blocked by implantation Device noumenon, the fast densified filling tumor chamber of energy after expansion reduce blood to tumor to slow down flowing of the blood in aneurysm cavity The surge of chamber reinforces repair ability, reaches the aneurysmal purpose for the treatment of.
After plugging device is placed in aneurysm, struts and be adjacent to vascular wall generation support force in " ellipse ", it is equal by high density Even netted Ultimum Ti silk clogs tumor chamber, slows down velocity of blood flow, accelerates thrombus cohesion, promotes vascular repair healing.
Detailed description of the invention
Attached drawing 1 is a kind of plugging device structural schematic diagram of intracranial aneurysm of the utility model.
Attached drawing 2 is that the structure that a kind of plugging device of intracranial aneurysm of the utility model is placed in epimegetic aneurysm is shown It is intended to.
Attached drawing 3 is the structural schematic diagram of the production aneurysmal plugging device mold of novel encephalic of the utility model.
Attached drawing 4a is that the two sides of the utility model are in the front view of the wing aneurysmal plugging device of novel encephalic.
Attached drawing 4b is cross-sectional view of Fig. 4 a along line A-A.
It is dynamic that attached drawing 5a is that the two sides of the utility model in the wing aneurysmal plugging device of novel encephalic are placed in epimegetic Front view in arteries and veins tumor.
Attached drawing 5b is cross-sectional view of Fig. 5 a along line B-B.
Attached drawing 6a is the front view of the aneurysmal plugging device of novel encephalic of the up-narrow and down-wide shape of the utility model.
Attached drawing 6b is cross-sectional view of Fig. 6 a along the cross-sectional view of line C-C.
It is up-narrow and down-wide that attached drawing 7a is that the aneurysmal plugging device of novel encephalic of the up-narrow and down-wide shape of the utility model is placed in Front view in shape aneurysm.
Attached drawing 7b is cross-sectional view of Fig. 7 a along the cross-sectional view of line D-D.
Attached drawing 8 is the aneurysmal closure dress of novel encephalic that the utility model increases fixed-wing newly in plugging device body proximal end The front view set.
Attached drawing 9 is the aneurysmal closure dress of novel encephalic that the utility model increases fixed-wing newly in plugging device body proximal end It is placed in structural schematic diagram in branch type aneurysm.
Specific embodiment
The embodiments of the present invention is described in detail referring to attached drawing 1-9.
Appended drawing reference involved in attached drawing and component part are as follows:
1. 2. plugging device distal end developing mark of plugging device ontology
3. 4. burble point of plugging device proximal end developing mark
5. 6. delivery pipe of delivery guidewire
7. 8. aneurysm of separator
9. 10. mold of parent artery (1)
11. (2) 12. mold (3) of mold
13. 14 fixed-wing of developing mark on fixed-wing
15. connecting line
Attached drawing 1 is a kind of plugging device structural schematic diagram of intracranial aneurysm of the utility model.Plugging device includes envelope It is block apparatus ontology 1, plugging device distal end developing mark 2, plugging device proximal end developing mark 3, delivery guidewire 5, burble point 4, defeated Send pipe 6, separator 7;Plugging device ontology 1 is reticulated by 24-72 bursts of Ultimum Ti silk braidings;Plugging device ontology 1 For reticular structure, whole is in " cylinder ", and top and bottom are in " cone ", and the proximal end and distal end of plugging device ontology 1 all collect solid It is scheduled in plugging device distal end developing mark 2 and proximal end developing mark 3;It collapses when plugging device ontology 1 conveys in delivery pipe 6 In;Plugging device ontology 1 is expanded from inside to outside by delivery pipe 6 generates thrust by delivery guidewire 5;Plugging device proximal end developing mark 3 It is intermediate equipped with burble point 4 with 5 distal end of delivery guidewire;5 proximal end of delivery guidewire is equipped with separator 7, for disconnecting burble point 4.
Attached drawing 2 is that a kind of aneurysmal plugging device of novel encephalic of the utility model is placed in the knot in epimegetic aneurysm Structure schematic diagram.Plugging device ontology 1 is placed in epimegetic aneurysm 8;Plugging device ontology 1 is rendered as since tumor inner wall squeezes " ellipse ", top and bottom are in indent " cone ";1 side wall of plugging device ontology netted Ultimum Ti silk part and tumor wall are tight Closely connected conjunction;Plugging device ontology 1 is conveyed by the delivery pipe 6 entered in parent artery 9;There is delivery guidewire 5 in delivery pipe 6.
Attached drawing 3 is the structural schematic diagram of the plugging device mold of the production intracranial aneurysm of the utility model.Production should The plugging device mold of production intracranial aneurysm is spliced by two (1) 10, two, mold (2) 11, one, mold molds (3) 12 Composition.
Attached drawing 4a, 4b and 5a, 5b (preferably) be the utility model a kind of aneurysmal plugging device of novel encephalic and its It is placed in structural schematic diagram in epimegetic aneurysm.Plugging device is a kind of one of extension preferred embodiment of the utility model.Attached drawing 4a, 4b are the front view and cross-sectional view of this preferred new equipment;The present apparatus increases fixed-wing 14 newly in 1 proximal end of plugging device ontology;Gu The wing 14 is determined in reticular structure, and two sides are in " wing ";Fixed-wing 14, which distally collapses, is fixed on developing mark 13 on fixed-wing;Connection 15 proximal end of line is connected with developing mark 13 on fixed-wing, is distally connected with developing mark 3;Attached drawing 5a, 5b are this preferred new equipment The front view and cross-sectional view being placed in epimegetic aneurysm;Fixed-wing 14 is connected with plugging device ontology 1 by connecting line 15;Gu Determine the wing 14 and is placed in 8 opening of aneurysm;14 both wings of fixed-wing are close to respectively on 9 two sides vascular wall of parent artery.This preferred new clothes Set it is characterized in that: on original plugging device ontology 1 add fixed-wing 14,14 both wings of fixed-wing be close to 9 two sides of parent artery On vascular wall, vessel inner blood reduced velocity flow will not be made, prevent that thrombus is capable of fixing plugging device ontology 1 again;Aneurysm 8 with The acute angle wall that 9 vascular wall of parent artery is formed, meets the width in 14 connecting place gap of plugging device ontology 1 and fixed-wing, i.e., dynamic The acute angle wall that arteries and veins tumor 8 and 9 vascular wall of parent artery are formed is interspersed in 14 connecting place gap of plugging device ontology 1 and fixed-wing, A kind of fixed form is formd, such plugging device ontology 1 is not easily to fall off.
Attached drawing 6a, 6b and 7a, 7b ((preferably) be the utility model a kind of aneurysmal plugging device of novel encephalic and its It is placed in structural schematic diagram in low wide and up narrow type aneurysm.Plugging device is a kind of one of extension preferred embodiment of the utility model. Attached drawing 6a, 6b be this preferred new equipment device just attempt and cross-sectional view;The present apparatus is reticular structure, is in " up-narrow and down-wide shape "; The present apparatus increases fixed-wing 14 newly in 1 proximal end of plugging device ontology, preferably hemispherical;Fixed-wing 14 is in reticular structure, and two sides are in " wing ";Developing mark 13 on fixed-wing are fixed in the gathering of fixed-wing 14;Developing mark 13 on 15 proximal end of connecting line and fixed-wing It is connected, is distally connected with developing mark 3;Attached drawing 7a, 7b (are placed in the positive examination in up-narrow and down-wide shape aneurysm for this preferably new equipment Figure and cross-sectional view;Fixed-wing 14 is connected with plugging device ontology 1 by connecting line 15;Fixed-wing 14 is placed in 8 opening of aneurysm Distally;14 both wings of fixed-wing are close to 9 two sides of parent artery respectively.This preferably new equipment it is characterized in that: in original plugging device Fixed-wing 14 is added on ontology 1,14 both wings of fixed-wing are close to 9 two sides of parent artery, velocity of blood flow will not be made to slow down, prevented Thrombus is capable of fixing plugging device ontology 1 again;14 both wings of fixed-wing are close to 9 two sides of parent artery, fixed-wing 14 and plugging device sheet Body 1 is connected by connecting line 15, generates support force, plugging device ontology 1 is made to play fixed function in aneurysm 8.
Attached drawing 8 and 9 (preferably) is a kind of aneurysmal plugging device of novel encephalic of the utility model and its is placed in bifurcated Structural schematic diagram in type aneurysm.Plugging device is a kind of one of extension preferred embodiment of the utility model.Attached drawing 8 is that this is preferred The structural schematic diagram of new equipment;The present apparatus is reticular structure, is in " spherical shape ";The present apparatus is in the new reinforcement in 1 proximal end of plugging device ontology Determine the wing 14;Fixed-wing 14 is in reticular structure, and whole is in " bowl-type ";Developing mark 13 on fixed-wing are fixed in the gathering of fixed-wing 14; 15 proximal end of connecting line is connected with developing mark 13 on fixed-wing, is distally connected with developing mark 3;Attached drawing 8 be this new equipment as Structural schematic diagram in branch type aneurysm;Fixed-wing 14 is connected with plugging device ontology 1 by connecting line 15;Fixed-wing 14 Outer diameter be greater than plugging device ontology 1;Fixed-wing 14 and plugging device ontology 1 are placed in aneurysm 8 together.This preferably new equipment its Feature is: fixed-wing 14 is added on original plugging device ontology 1;Plugging device ontology 1 and fixed-wing 14 are all placed in artery In tumor 8;Because 14 outer diameter of fixed-wing is greater than plugging device ontology 1, when plugging device ontology 1 is distally bonded 8 inner wall of aneurysm Afterwards, fixed-wing 14 is bonded 8 opening inner side vascular wall of aneurysm, generates support force, fixed plugging device ontology 1;And because moving thus Arteries and veins tumor 8 is chiasma type aneurysm, direction of flow of blood and 8 face of aneurysm, causes greatly to bear to aneurysm 8, so solid Determine the wing 14 other than fixed function, velocity of blood flow can be slowed down, blood after slowing down flow velocity after plugging device ontology 1 again It is secondary to be reduced, significantly reduce the pressure of aneurysm 8.
When interventional therapy, 8 position of intracranial aneurysm is determined by angiography first, plugging device ontology 1 is placed in conveying In pipe 6, then the present apparatus is imported from femoral artery or arteria brachialis it is intravascular, push delivery pipe 6 to parent artery 9 at, pass through Developing mark 2 determines 1 position of plugging device ontology, when confirmation 6 distal end of delivery pipe passes through aneurysm 8 aperture position, touches and send Delivery guidewire 5 discharges plugging device ontology 1, and titanium-nickel wire memory wire generates memory deformation, plugging device after leaving delivery pipe 6 Ontology 1 opens vascular wall in fitting tumor completely, is then turned off burble point 4, withdraws delivery guidewire 5 and delivery pipe 6.
The utility model is a kind of aneurysmal plugging device of novel encephalic, in the case where not opening cranium, is sealed by merging Block apparatus ontology 1, the fast densified filling tumor chamber of energy reach treatment aneurysm to slow down the blood flowing intracavitary in aneurysm 8 8 purpose.The utility model extends three kinds of preferred new plugging devices, and type up-narrow and down-wide for encephalic, epimegetic, branch type are dynamic Arteries and veins tumor 8 has done different device schemes, and scheme increases fixed-wing 14 on original basis plugging device ontology 1, in different schemes Middle fixed-wing 14 produces very big effect, and in up-narrow and down-wide type aneurysm 8, fixed-wing 14 plays very big support and makees With preventing plugging device from falling off;
In epimegetic aneurysm 8, fixed-wing 14 plays very big fixed function, prevents plugging device from falling off;Dividing In forked type aneurysm 8, fixed-wing 14 plays very big fixed function, and greatly reduces the flow velocity of blood, plays very Good protective effect.The plugging device stable structure, the fast densified filling tumor chamber of energy after expansion, to slow down blood in aneurysm Intracavitary flowing reduces blood to the surge of tumor chamber, reinforces repair ability, reaches the aneurysmal purpose for the treatment of.
The above is preferred embodiments of the present invention, and those skilled in the art are practical without prejudice to this Equivalent deformation or replacement can be also made under the premise of novel spirit, these equivalent variation or replacement are all contained in the application right It is required that in limited range.

Claims (6)

1. a kind of plugging device of intracranial aneurysm, which is characterized in that the plugging device includes plugging device ontology, blocks dress Set proximal end developing mark, plugging device distal end developing mark, delivery guidewire, burble point, delivery pipe, separator, the closure dress It sets proximal end developing mark and plugging device distal end developing mark is separately fixed at the distal end of the plugging device ontology and close End;The plugging device ontology is reticulated by 24-72 bursts of Ultimum Ti silk braidings;The delivery guidewire is located at described defeated It send in pipe;The burble point is equipped among the distal end of plugging device proximal end developing mark and the delivery guidewire;It is described defeated The proximal end of seal wire is sent to be connected with the separator.
2. the plugging device of intracranial aneurysm according to claim 1, which is characterized in that the plugging device ontology it is remote End beam holds together to be fixed on the developing mark of the plugging device distal end, and the proximal end beam of the plugging device ontology, which holds together, is fixed on the envelope On the developing mark of block apparatus proximal end, the proximal end of the plugging device ontology is connected with the burble point, the delivery guidewire, and leads to It is mobile to cross the delivery guidewire.
3. the plugging device of intracranial aneurysm according to claim 1, which is characterized in that the plugging device ontology can be with It is uniform cylindric, or intermediate is in that the spherical or proximal end swelled is connected with the hemispherical of fixed-wing.
4. the plugging device of intracranial aneurysm according to claim 1, which is characterized in that the plugging device passes through described Burble point separates the plugging device ontology and the delivery guidewire.
5. the plugging device of intracranial aneurysm according to claim 1, which is characterized in that the plugging device passes through described Separator disconnects the burble point.
6. the plugging device of intracranial aneurysm according to claim 2, which is characterized in that the plugging device is intrinsic Plugging device proximal end developing mark and the plugging device distal end developing mark height are no more than the plugging device ontology Top and bottom.
CN201821298904.7U 2018-08-14 2018-08-14 The plugging device of intracranial aneurysm Active CN209450597U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022222256A1 (en) * 2021-04-21 2022-10-27 上海苏畅医疗科技有限公司 Aneurysm occlusion device and preparation method therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022222256A1 (en) * 2021-04-21 2022-10-27 上海苏畅医疗科技有限公司 Aneurysm occlusion device and preparation method therefor

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