CN1048752C - Disinfecting detergent and preparation method thereof - Google Patents
Disinfecting detergent and preparation method thereof Download PDFInfo
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- CN1048752C CN1048752C CN95102774A CN95102774A CN1048752C CN 1048752 C CN1048752 C CN 1048752C CN 95102774 A CN95102774 A CN 95102774A CN 95102774 A CN95102774 A CN 95102774A CN 1048752 C CN1048752 C CN 1048752C
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Abstract
The present invention relates to a disinfecting detergent and a preparation method thereof. The formula of the detergent comprises sodium fatty alcohol ether sulphate, alkyl benzene sulfonate, a complex nonionic surface active agent, a stabilizing agent, sodium carboxymethyl cellulose, sodium ethylene diamine tetracetate, iodine, iodide salt and water as the rest. The preparation method of the detergent comprises: firstly adding the alkyl benzene sulfonate, the complex nonionic surface active agent, the sodium ethylene diamine tetracetate and the sodium carboxymethyl cellulose into the water, heating and stirring the mixture; then orderly adding the sodium fatty alcohol ether sulphate, the stabilizing agent, the iodide salt and the iodine; at last ageing the mixture to prepare the detergent. The present invention has the washing and disinfecting functions and has the advantages of stable disinfecting components and no stimulation.
Description
The present invention relates to a kind of disinfecting detergent and preparation method thereof.
At present, the sterilizing agent and the washing composition overwhelming majority are the simple function product on the market.The most extensive as sterilizing agent with chloride dose of use, but this detergent with sterilizing is single owing to cleaning ingredients, and its washing effect such as detersive power, emulsifying power etc. are starkly lower than common washing composition; And chlorine-containing disinfecting washing composition poor stability, corrodibility is strong, toxicity is high, pungency is big, thereby can't satisfy the multiple demand of daily life.Common washing composition only has single washing function again, and does not have sterilizing function, thereby also can't satisfy the multiple demand of daily life." a kind of disinfectant detergent powder and manufacture method thereof " disclosed in Chinese patent CN1041613A, this washing powder mainly is to be base-material with the anion surfactant, add materials such as Efficacious Disinfeitant therein, adopt chemically bulked comminution granulation to be prepared from, this washing powder needs tool decontamination, disinfectant dual-use function, but its weak point is still basic identical with chlorine-containing disinfectant, and this laundry can't be made liquor with compound/composition.The chlorine-containing disinfecting washing composition mostly is solid shape greatly by retrieval, all can't make aqueously, contains the active substance that short chlorine decomposes in the aqueous washing composition of Yin Putong mostly, and the two-in-one function of liquid compound cleaning and disinfecting of chlorine agent can't be realized.
The objective of the invention is aqueously to have that washing, sterilizing function, disinfection composition are stable concurrently in order to provide a kind of, nonirritant, sterilisation effect obviously and have no side effect, disinfecting detergent that the preparation method is easy and preparation method thereof.
Purpose of the present invention can realize by following measure:
A kind of formulation weight percentage composition of disinfecting detergent is:
Polyoxyethylenated alcohol sodium sulfate 8-15%
Alkylbenzene sulfonate 5-8%
Solvay-type nonionogenic tenside 5-8%
Stablizer 2-6%
Xylo-Mucine 0.1-1%
Sodium ethylene diamine tetracetate 0.1-1%
Iodine 0.5-2%
Iodized salt 1-2%
Its surplus is a water.
The preparation method of this washing composition is undertaken by following steps in sequence:
(1) takes by weighing each component by the weight percentage in the prescription, get alkylbenzene sulfonate, solvay-type nonionogenic tenside, sodium ethylene diamine tetracetate, Xylo-Mucine and add in the entry, and 45-75 ℃ of heating, stir the 15-30 branch;
(2) again polyoxyethylenated alcohol sodium sulfate is added in (1) mixed solution, and stirred 30-40 minute;
(3) then the mixed solution of stablizer and iodized salt is added above-mentioned mixed solution, and stirred 10-20 minute;
When (4) being cooled to 20-25 ℃ at last, adding iodine again and stir after 30-40 minute to the mixed solution, can produce in ageing 1-2 days.
Purpose of the present invention also can realize by following measure:
Solvay-type nonionogenic tenside in a kind of prescription of disinfecting detergent can be long-chain fat polyoxyethylenated alcohol and isomer thereof, propanediol polyoxypropylene Soxylat A 25-7; Stablizer can be alkylolamide, lauric acid diethanolamine, lauroyl Propanolamine.
The present invention has following advantage compared to existing technology:
1. the present invention has added sulphur in main lotion anion surfactant polyoxyethylenated alcohol sodium sulfate and alkylbenzene sulfonate, make this washing composition in the tool washing function, have sterilizing function again concurrently, overcome in common aqueous washing composition and can't contain the defective of sterilizing function, and ill effect such as avoided using the toxicity of bringing of chlorine-containing disinfectant big, pungency is strong.
2. in the technological process of the present invention, before adding iodine, added the stablizer and the iodized salt solubility promoter of iodine earlier, iodine is fully dissolved in washing composition and improved its stability, made washing composition shelf-time lengthening.
3. the present invention has also added the solvay-type nonionogenic tenside in prescription, this compound can with iodine generation complex reaction, thereby the yellow pigment that has overcome idodine easy contaminant surface after use, and when using to the skin weak points such as cusalgia sense that the surface of a wound causes of especially festering.
4. the present invention is the red-brown translucent liquid, deposits between Celsius-10-30 ℃ and does not have precipitation, free from extraneous odour, and solubleness is 100% in its water, (50-200ppm) Ph value＜10.0 under working concentration, nonirritant; The surfactant content of product of the present invention is 15%, and its detersive power is higher than two one-tenth of standard wash agent, and the rate of deoiling is a times of standard wash agent.
5. product of the present invention is to bacterium such as intestinal bacteria, golden yellow staphylococcus and Pseudomonas aeruginosa, bacillus subtilis black variety bud cells, and sterilizing rate can reach 99.9%; But to the hepatitis B virus deactivation; Sterilizing rate to pollution vessel such as the tableware that carries disease germs, glass can reach 94.12%-97.64%; Nontoxicity of the present invention, nothing corrosion.
6. preparation method of the present invention is simple, technology is convenient and reliable.
The present invention also will be described in further detail in conjunction with the embodiments:
Embodiment one:
A kind of formulation weight percentage composition of sterilizing agent washing composition is: polyoxyethylenated alcohol sodium sulfate 15%, sodium alkyl benzene sulfonate 5%, aliphatic alcohol polyethenoxy (7) ether 6%, alkylolamide 2%, Xylo-Mucine 1%, sodium ethylene diamine tetracetate 1%, iodine 1%, potassiumiodide 1%, its surplus is a water.
The preparation method of this washing composition is undertaken by following steps in sequence:
(1) takes by weighing each component by the weight percentage in the prescription, get sodium alkyl benzene sulfonate, aliphatic alcohol polyethenoxy (7) ether, sodium ethylene diamine tetracetate, Xylo-Mucine and add in the entry, and heat 60 ℃, stirred 25 fens;
(2) again polyoxyethylenated alcohol sodium sulfate is added in (1) mixed solution, and stirred 35 minutes;
(3) then the mixed solution of alkylolamide and potassiumiodide is added above-mentioned mixed solution, and stirred 15 minutes;
When (4) being cooled to 25 ℃ at last, adding iodine again and stir after 35 minutes to the mixed solution, ageing can be produced in 1 day.
Embodiment two:
A kind of formulation weight percentage composition of disinfecting detergent is: polyoxyethylenated alcohol sodium sulfate 8%, Sodium dodecylbenzene sulfonate 8%, aliphatic alcohol polyethenoxy (9) ether 8%, lauroyl diethanolamine 6%, Xylo-Mucine 0.1%, sodium ethylene diamine tetracetate 0.1, iodine 0.5%, potassiumiodide 0.5%, its surplus is a water.
Its preparation method and example are together.
Embodiment three:
A kind of formulation weight percentage composition of disinfecting detergent is: polyoxyethylenated alcohol sodium sulfate 12%, Sodium dodecylbenzene sulfonate 7%, aliphatic alcohol polyethenoxy (10) ether 3%, lauroyl Propanolamine 4%, Xylo-Mucine 0.5%, sodium ethylene diamine tetracetate 0.5%, iodine 0.2%, potassiumiodide 2%, its surplus is a water.
Its preparation method and example are together.
Embodiment four:
A kind of formulation weight percentage composition of disinfecting detergent is: polyoxyethylenated alcohol sodium sulfate 10%, sodium alkyl benzene sulfonate 6%, aliphatic alcohol polyethenoxy (15) ether 5%, lauroyl Propanolamine 5%, Xylo-Mucine 0.7%, sodium ethylene diamine tetracetate 0.7%, iodine 1.5%, sodium iodide 1.8%, its surplus is a water.
Its preparation method and example are together.
Embodiment five:
A kind of formulation weight percentage composition of disinfecting detergent is: polyoxyethylenated alcohol sodium sulfate 13%, sodium alkyl benzene sulfonate 6.5%, propanediol polyoxypropylene Soxylat A 25-7 7%, alkylolamide 3%, Xylo-Mucine 0.9%, sodium ethylene diamine tetracetate 0.9%, iodine 1.2%, sodium iodide 1.2%, its surplus are water.
Its preparation method and example are together.
Use experiment effect of the present invention is as follows:
One, microbicidel test:
(1) bactericidal assay: by Ministry of Health's version " disinfection technology standard " in 1991 operation.(table 1 is seen the literary composition back)
(2) HBsAg and HBeAg rupture test (table 2 is seen the literary composition back)
Sterilization method: positive serum mixes with the detergent with sterilizing diluent with 1: 4 ratio after diluting with physiological saline, and different time adds the equivalent neutralizing agent, measures after 10 minutes: HBsAg and HBeAg, every hole 100 microlitres.The China ELISA of section medicine box.
Animal immune is observed: cancel malicious post neutralization mixed solution (table 2 concentration and action time), every mice by intraperitoneal injection 1ml strengthened once after 3 days, surveyed HBsAg and HBeAg after 21 days, surveyed positive serum, normal serum control group simultaneously.The result: specific antibody reaction (sAb and eAb) all appears in positive controls, and the sterilization group is all negative.
(3) organic substance influence test
Normal human serum 0%, 5% and 10% adds in the various concentration elimination detergents, and obviously influence is not found in four kinds of bacterium sterilizations; There is not obvious effect to destroying HBsAg and HBeAg antigenicity yet.This effect is that a big advantage of this product has promptly been eliminated organism to the bigger deficiency of general iodine shadow, for guaranteeing that effectively sterilization provides assurance.
Two, simulated field sterilization
(1) to the bacterium sterilisation effect
(table) is to bacterium sterilisation effect (table 3 is seen the literary composition back)
Pollute with bacterial concentration 1.4 * 1000000 CFU/ml, get 0.5ml and pollute 50 sq, 1 hour drying of 37 degree Celsius.Get 0.5ml inoculation counting after 10 minutes with adding the equivalent neutralizing agent behind the different concns immersion different time.
(2) destroy the HBsAg on-site disinfection test
With 1: crusts such as 256HBsAg positive serum tablewares, natural drying at room temperature 2 hours, soak 10 minutes post neutralization with the 200ppm scavenging solution and handle, and get in the scouring and mixed solution survey HBsAg (ELISA method), the result does not all send out HBsAg on tableware, glass and plastics.
Three, stability test
(1) natural reserved is observed: product is placed down at high temperature (25 degree Celsius), measures available iodine once in every month, observes six months altogether, and available iodine descends 1% altogether.Under working concentration (200ppm), be placed in the porcelain basin and add a cover, high temperature was observed 10 days, the results are shown in Table 4,5.(table 4,5 is seen the literary composition back)
The diluent available iodine is measured: get the 10ml diluent, add Starch Indicator 1-2 and drip, move back to the greatest extent with 0.001Mol/L Sulfothiorine titration to blueness.Every 1ml Sulfothiorine is equivalent to the iodine of 0.126mg.
(2) accelerated test: 500ml disinfecting detergent packing bottle, put in the thermostat container of 40 degree (error is in 0.11 degree), placed 3 months, surveyed available iodine once, and descended 6.89% after three months as a result in every month.(table 6 is seen the literary composition back)
Four, corrosion test
With stainless steel blade, medical scissors and tweezers, emgloves and emulsion tube, gauze, mouth mask are put to soak after 1 day in the 200ppm lotion and are observed, and find no obvious corrodibility.
Stainless steel blade is not seen rust shape spot, and blade is sharp
The hospital scissors tweezer is not seen rust shape spot, and coating gloss is bright
Emgloves, Guan Weijian are clamminess, variable color, and elasticity does not have change
Gauze, mouth mask non-coloring have certain bleaching action
Blue woollen cloth do not see fade, piebald
Five, toxicological test
LD50 measures: 18-22g small white mouse, 10 every group, male and female half and half, leaves of pulse plants stomach.Result: stoste LD50=4850mg/kg; The highest working concentration (200ppm) LD50＞28000MG/kg.
The skin irritation test: big white mouse is coated with once with stoste 0.2ml every day, in a continuous week, does not find red swelling of the skin, diabrosis and thickens phenomenon.
Table 1 quantitatively kill vegetative forms of bacteria and brood cell's effect (99.9% sterilizing rate) bacterial classification bacterial concentration is (individual/ml) (AT6538) Pseudomonas aeruginosa 6.6 * 1,000,000 20 (75) 1 (1) bacillus subtilis vars 9.1 * 1,000,000 75 (150) 10 (5) ATCC 9372 of drug concentration (ppm) action time (dividing) Escherichia coli 8,099 6.1 * 1,000,000 20 (75) 5 (1) staphylococcus aureus 7.1 * 1,000,000 20 (75) 10 (1)
Table 2 destroyed HBsAg and 1: 2 150 5-(S/N＜2) HBeAgl:1024 of HBeAg antigenicity effect measuring positive serum extent of dilution drug level (ppm) action time (branch) result (ELISA) HBsAgl:1028 1: 3 150 2-(S/N＜2)
Bacterium number sterilization back bacterium is counted sterilizing rate before table 3 pair index bacterium simulated field sterilization observation index bacterial classification drug level sterilization action time
(ppm), (second) CFU/ square centimeter CFU/ square centimeter, (%) intestinal bacteria 8,099 75 5 136 8 94.12 streptococcus aureuses 75 5 338.5 8 97.64, (AT6538) Pseudomonas aeruginosa 75 5 361.5 11.5 97.10 bacillus subtilis vars 75 5 326 8 97.55ATCC9372
Table 4 product room temperature (25 degree) natural reserved is down observed
Time (moon) 123456 available iodine contents (%) 0.500 0.500 0.499 0.498 0.496 0.495 rate of descent (%) 00 0.2 0.4 0.8 1.0
Table 5 working concentration (200ppm) room temperature (25 degree) natural reserved is down observed
Time (my god) 0 0.5 1247 10 available iodine contents (%), 200 195.8 189.76 95.94 68.8 25.8 11.4 rates of descent (%) 0 2.10 5.12 52.03 65.60 82.10 94.30
Table 6 product stability accelerated test (25 degree Celsius)
Time (moon) 0123 available iodine contents (%) 0.500 0.4893 0.4764 0.4656 rate of descent (%) 0 2.14 4.72 6.89
Claims (2)
1. a disinfecting detergent is characterized in that the formulation weight percentage composition of this washing composition is: polyoxyethylenated alcohol sodium sulfate 8-15%
Alkylbenzene sulfonate 5-8%
Solvay-type nonionogenic tenside 5-8%
Stablizer 2-6%
Xylo-Mucine 0.1-1%
Sodium ethylene diamine tetracetate 0.1-1%
Iodine 0.5-2%
Iodized salt 1-2%
Its surplus is a water: described solvay-type nonionogenic tenside is selected from a kind of in long-chain fat polyoxyethylenated alcohol and isomer thereof, the propanediol polyoxypropylene Soxylat A 25-7; Described stablizer is selected from a kind of in alkylolamide, lauroyl diethanolamine, the lauroyl Propanolamine.
2. the preparation method of the described sterilization type of claim 1 sanitising agent is characterized in that the preparation method of this washing composition is undertaken by following steps in sequence:
(1) takes by weighing each component by the weight percentage in the prescription, get alkylbenzene sulfonate, be selected from long-chain fat polyoxyethylenated alcohol and isomer thereof, a kind of solvay-type nonionogenic tenside, sodium ethylene diamine tetracetate, Xylo-Mucine adds in the entry in the propanediol polyoxypropylene Soxylat A 25-7, and 45-75 ℃ of heating, stirs the 15-30 branch;
(2) again polyoxyethylenated alcohol sodium sulfate is added in (1) mixed solution, and stirred 30-40 minute;
(3) will be selected from the stablizer a kind of in alkylolamide, lauroyl di-alcohol ammonium, the lauroyl Propanolamine and the mixed solution of iodized salt then and add above-mentioned mixed solution, and stir 10-20 minute;
When (4) being cooled to 20-25 ℃ at last, adding iodine again and stir after 30-40 minute to the mixed solution, can produce in ageing 1-2 days.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95102774A CN1048752C (en) | 1995-03-15 | 1995-03-15 | Disinfecting detergent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95102774A CN1048752C (en) | 1995-03-15 | 1995-03-15 | Disinfecting detergent and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1114679A CN1114679A (en) | 1996-01-10 |
| CN1048752C true CN1048752C (en) | 2000-01-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95102774A Expired - Fee Related CN1048752C (en) | 1995-03-15 | 1995-03-15 | Disinfecting detergent and preparation method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102311887B (en) * | 2011-08-18 | 2013-01-16 | 瓮福（集团）有限责任公司 | Iodine-containing antibacterial washing agent |
| CN103006446A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing toilet water |
| CN106937646B (en) * | 2017-03-29 | 2021-01-01 | 佛山市南海东方澳龙制药有限公司 | Preparation method of iodic acid mixed solution and iodic acid mixed solution prepared by same |
| CN106821974B (en) * | 2017-03-29 | 2021-04-02 | 佛山市南海东方澳龙制药有限公司 | Preparation method of povidone-iodine solution and povidone-iodine solution prepared by same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1038303A (en) * | 1988-06-04 | 1989-12-27 | 宛吉斌 | The efficient disinfectant liq soap |
| CN1095757A (en) * | 1993-05-22 | 1994-11-30 | 衡阳医学院 | A kind of sterilizing detergent and production method thereof |
-
1995
- 1995-03-15 CN CN95102774A patent/CN1048752C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1038303A (en) * | 1988-06-04 | 1989-12-27 | 宛吉斌 | The efficient disinfectant liq soap |
| CN1095757A (en) * | 1993-05-22 | 1994-11-30 | 衡阳医学院 | A kind of sterilizing detergent and production method thereof |
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| Publication number | Publication date |
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| CN1114679A (en) | 1996-01-10 |
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