CN101502261A - Stable thickening type quaternary ammonium salt composition - Google Patents
Stable thickening type quaternary ammonium salt composition Download PDFInfo
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- CN101502261A CN101502261A CNA200810154396XA CN200810154396A CN101502261A CN 101502261 A CN101502261 A CN 101502261A CN A200810154396X A CNA200810154396X A CN A200810154396XA CN 200810154396 A CN200810154396 A CN 200810154396A CN 101502261 A CN101502261 A CN 101502261A
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- dimethyl ammonium
- water
- quaternary ammonium
- cellulose esters
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Abstract
The present invention discloses a stabilized thickening quaternary ammonium compound which comprises the following components: quaternary ammonium, cellulose ester thickening agent and water. The compound has the advantages of transparency, easy dissolving into the water and stable capability. The stabilized thickening quaternary ammonium compound of the invention is suitable for sterilizing, cleaning and mildew prevention for household use, medical use and industrial use, eliminating algae in swimming pool, sterilizing in clothes washing process, daily sterilizing of pet, etc.
Description
Technical field
The present invention relates to stabilized thickened type quaternary ammonium salt composition.Specifically, the present invention relates to be fit to family expenses, medical and industrial sterilization, sterilization, cleaning, mildew-resistant, the algae removal class is sterilized in the laundry processes in the swimming pool, the daily sterilization of pet etc.
Background technology
Along with the raising that epidemic prevention disease is realized and the expansion of raising pets amount, increasing people has recognized the importance of sterilization.Pursuing the safety of disinfectant, efficient nonirritant, permeability and duration, is consumer's general psychology.The hypochlorite solutions that traditional amount ratio is bigger since intrinsic to mucous membrane irritation, easily cause the shortcoming of fabric fading, the manufacturer of product has developed the alternate sets compound based on quaternary amine.But now not only kind is few for the quaternary ammonium salts disinfectant of listing, and formulation is single, is solution, poor permeability but also short not only in the time of staying that object shows, and the Disinfection Effect duration is short.Therefore invented stable thickener comprises quaternary ammonium salt composition with raising usability.
Summary of the invention
Invented stable thickening type quaternary ammonium salt disinfectant.After this disinfectant agent process thickening, the time of staying significant prolongation on non-horizontal surface, bactericidal action time and bactericidal effect have obtained obvious lifting.
The present invention is a kind of thickener composition that comprises quaternary amine.Said composition comprises: the cellulose esters thickener of the quaternary amine of 0.01%-15% part by weight, 0.01%-5% part by weight or cellulose esters mixtures of thickening agents and water.The viscosity of described composition is greater than 500cP.The composition that comprises the thickening of quaternary amine can storage-stable.
The cellulose esters that is used for thickening comprises for example Hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose, propyl cellulose, hydroxypropyl cellulose etc.The viscosity of the quaternary ammonium salt composition of described thickening will depend on one or more used in composition cellulose esters thickeners, their concentration and the required viscosity of purposes of said composition expection.
The composition that comprises quaternary amine of described stabilized thickened comprises the quaternary amine of 0.01%-15% weight usually, preferred 1%-12%, the more preferably quaternary amine of 9%-11% weight.Quaternary amine can be buied on market, and its typical structure feature is:
R wherein
1, R
2Be the structure of hydrocarbon chain or band phenyl ring, hydrocarbon chain or phenyl ring band side chain or be not with side chain, X is a halide ion.Typical material has: the derivative and the compound of alkyl dimethyl ammonium halide, two alkyl dimethyl ammonium halide, dodecylbenzyl alkyl dimethyl ammonium chloride, dodecyl benzyl dimethyl ammonium bromide, softex kw, two certain herbaceous plants with big flowers base alkyl dimethyl ammonium chloride, dodecyl dimethyl ammonium halide and these materials thereof.
May need to add flavouring agent in described composition, with the usability of enhancing composition, the flavouring agent of adding is water miscible essence, and essence such as water quality lemon, water quality fragrance of a flower fruital, water quality forest, water quality chamomile are typically arranged.
After having solved other all components, the surplus of described stabilized thickened type quaternary ammonium salt composition is a water.Because the aqueous solution of the 30%-80% that quaternary amine is normally buied on the market needs the dilute with water quaternary amine, usually to obtain required quaternary amine concentration.Described water should not contain can with the inorganic material of quaternary amine reaction, for example chlorine (Cl
2), hypochlorous acid (HOCl) and clorox (NaOCl).Preferred distilled water, purified water or deionized water.
Industrial applicibility
Described stabilized thickened type quaternary ammonium salt composition can be used for family expenses, medical and industrial sterilization, sterilization, cleaning, mildew-resistant, and the algae removal class is sterilized in the laundry processes in the swimming pool, the daily sterilization of pet etc.They clean the surface that is contacted and sterilize, and therefore can be used as antiseptic solution or disinfectant lotion.They can guarantee between the object that be cleaned and/or sterilize and the described composition that the method that well contacts uses by any.For example spraying process or swabbing process are then by for example with water wash and/or clean and remove.Described stabilized thickened type quaternary ammonium salt composition also can be used as algae removal class in the swimming pool, sterilizes the daily sterilization of pet etc. in the laundry processes.
Embodiment
Can observe beneficial property of the present invention with the following Examples, these embodiment are illustrative, can not be construed as limiting the present invention.
The preparation of embodiment 1, stabilized thickened type quaternary ammonium salt composition
Unless otherwise indicated, the compound method that described sample comprises the hydroxy propyl cellulose promotor composition of 10% moon benzyl three Matsubains and 0.6%-1.2% is: hydroxypropyl cellulose is mixed with purified water, fully stir evenly, behind the liquid stabilising, slowly add month benzyl three Matsubain solution (conversion content) while stirring; Add 0.5% water quality lemon extract, use the purified water constant volume then, promptly get thickening type quaternary ammonium salt composition after fully stirring.
Embodiment 2, thickening type quaternary ammonium salt composition study on the stability evaluation method
Unless other explanation is arranged, otherwise all adopts following step to carry out estimation of stability.Described sample is placed 60 ℃ of baking ovens.Measure appearance character, the viscosity of composition described in the study on the stability process, also measure month benzyl three Matsubain content of effective in the described composition in some cases.Use the full-automatic kinematic viscosity tester of SYD-04 type (production of east, Jilin tall and sturdy science and technology (instrument) Co., Ltd) to measure the viscosity of composition, viscosity unit is cP, by measure the concentration of moon benzyl three Matsubains with the tetraphenylboron sodium titration.
Embodiment 3, the test of thickening type quaternary ammonium salt study on the stability
This embodiment has shown the viscosity of month benzyl three Matsubain samples that comprise Hydroxypropyl methylcellulose thickener, essence and the wherein variation of month benzyl three Matsubain concentration.Prepared following sample according to embodiment 1 general step, and carried out the properties of sample evaluation, the results are shown in table 1 by the study on the stability method of embodiment 2.
Sample 1 comprises 10% moon benzyl three Matsubains and 0.6% hydroxypropyl cellulose.
Sample 2 comprises 10% moon benzyl three Matsubains and 0.7% hydroxypropyl cellulose.
Sample 3 comprises 10% moon benzyl three Matsubains and 0.9% hydroxypropyl cellulose.
Sample 4 comprises 10% moon benzyl three Matsubains and 1.2% hydroxypropyl cellulose.
Table 1 contains the moon benzyl three Matsubain stabilities of solution of different proportion thickener and investigates (placement is stablized 60 ℃)
*: be moon benzyl three Matsubain content (being equivalent to labelled amount), following content is meaning for this reason all.
From the study on the stability result as can be seen, when sample stores under 60 ℃ temperature, the concentration of its viscosity and month benzyl three Matsubains does not all have too big variation, show that system is stable, comprehensive viscosity effect and economic factor, select to contain 10% the moon benzyl three Matsubains and 0.7% hydroxypropyl cellulose prescription comparatively suitable.
The acquisition of embodiment 4, antiseptic property working sample
Embodiment 3 shown and comprised 10% moon benzyl three Matsubains, 0.7% hydroxypropyl cellulose, relatively more suitable popularization of sample 2 of 0.5% water quality lemon extract, so we enlarge total capacity, prepared sample 2 by the method among the embodiment 1 again.
Sample 2 normal temperature were kept sample 10 days, and the sample after obtaining normal temperature and keeping sample is designated sample 5;
Sample 2 high temperature were quickened 10 days for 60 ℃, obtain quickening to keep sample sample, be designated sample 6.
The mensuration of Disinfection Effect after embodiment 5, thickening type quaternary ammonium salt sample quicken to keep sample
Get 1g sample 5,1g sample 6 respectively thin up be 0.1%, 0.2% and the solution of 0.3% 3 kind of variable concentrations, standby.The neutralizer of disinfectant is selected Tween 80 (20%).Carry out the quantitative assay of sample sterilizing ability by following operational procedure.
1, the preparation of test organisms liquid and metering
The preparation of bacterial suspension is with reference to " disinfectant for animals authenticate technology standard (trying) ", and the single bacterium colony of picking Escherichia coli (8099) is inoculated in the corresponding broth bouillon, cultivates 18-24h for 37 ℃, and is standby.
The viable bacteria metering of test strain.
(1) dilution: with the bacterial propagule bacteria suspension with turbidimetry according to a preliminary estimate bacterium liquid contain bacteria concentration, make serial dilution by 10 times then;
(2) inoculation: the bacterium liquid 0.1ml that draws dilution adds a small amount of aseptic water in ordinary broth agar solid culture plate respectively, makes bacterium liquid be evenly distributed on the surface of plate, and 3 plates of each dilution factor inoculation are inoculated 2～3 dilution factors, put 37 ℃ and join foster;
(3) counting: select clump count scope person's counting (undiluted stoste deficiency also should be counted) between 30～300.Count results is converted into every milliliter of viable count that stoste is contained, and calculates this dilution average bacterium number.Error rate between flat board or between dilution factor surpasses 10% and should reform.
2, quantitative test
2.1 method step
2.1.1 the bacterium liquid for preparing is carried out count plate, and with the dilution of 0.03M phosphate buffer, the bacteria containing amount that makes test organisms liquid is 2 * 10 then
6Individual/ml.
2.1.2 draw 0.5ml test organisms liquid in the disinfectant solution 4.5ml of test concentrations, mixing.Each concentration gradient is done 3 parallel repetitions.
2.1.3 put in 20 ℃ of water-baths and act on 5 minutes.
2.1.4 draw above-mentioned bacterium medicine mixed liquor 1.0ml immediately, add in the 9.0mL neutralizer mixing.
2.1.5 substitute thimerosal, carry out above steps simultaneously, in contrast group with the 0.03M phosphate buffer.
2.1.6 in and carry out count plate after 10 minutes.
The result
The sterilizing rate result of calculation of variable concentrations sample 5, sample 6 is as follows.
The table 2 stabilized thickened type moon benzyl three Matsubain Disinfection Effect quantitative expeditions
Annotate: the result is the mean value of 3 parallel sample.
From the quantitative expedition of bactericidal effect as can be seen, composition has the good sterilization effect, and more stable, can be used for clinical sterilization, cleaning etc.
Embodiment 6, thickening type disinfectant and routine disinfection agent sterilisation quality are detected
For comparing thickening type disinfectant and routine disinfection agent sterilisation quality, green bird egg Ji Chang has carried out the Disinfection Effect comparative trial in Tianjin for we.
Method: utilize that two facilities of Tianjin green bird egg chicken factory are in full accord, on all four two of epidemic prevention condition and raising chicken number raise house (raise house 1 and raise house 2) effect detection carries out disinfection.
After 1000 times of 2 dilutions of the sample among the embodiment 2, carry out spraying disinfection to raising house 1 environment; After 1000 times of commercially available golden allusion quotation 2008 (the archaic and abstruse Si Da in Inner Mongol Industrial Co., Ltd.) dilutions, carry out spraying disinfection to raising house 2 environment.After disinfecting 6 hours, the room air of raising house 1,2 adopts the ordinary nutrient agar flat board of diameter 9cm at each sampled point sedimentation 5min, with II, III class place total number of bacteria≤200cfu/m
3With≤500cfu/m
3For qualified.Chicken coop surface, hopper wiped away with aseptic cotton smear sampling, bacterial detection sum and pathogenic bacteria are with II, III class place total number of bacteria≤5cfu/m
3With≤10cfu/m
3For qualified. sterility test is carried out in the sterilizing article random sampling, serves as that sterilization is qualified with every whole asepsis growths of sample.
The result: continuous 3 testing results show, after two kinds of thimerosal sterilizations, all have significant difference in IAQ qualification rate, sterilizing article qualification rate, and there is clear superiority in the thickening type disinfectant.Concrete data see the following form 1.
Table 1 thickening type disinfectant (sample 2) and golden allusion quotation 2008 Disinfection Effects detect
From above result of the test as can be seen, the thickening type disinfectant duration is obviously long than common disinfectant, sterilize after 6 hours, the separation number of sterilization place microorganism significantly is lower than common disinfectant, the sterilization qualification rate is all more than 96%, and behind the common disinfectant sterilization certain hour, it is obviously many than the thickening type disinfectant that bacterium detects number, and the component environment qualification rate is low to moderate below 87%.Illustrate through thickening and handle that the sterilization duration of disinfectant obviously prolongs.
Claims (6)
1. composition, said composition comprises: the cellulose esters thickener of the quaternary amine of 0.01%-15% part by weight, 0.01%-5% part by weight or cellulose esters mixtures of thickening agents and water.The viscosity of described composition is greater than 500cP.
2. composition as claimed in claim 1 is characterized in that described composition comprises the quaternary amine of 0.01%-15% part by weight.The feature of quaternary amine is that it is a cationic surfactant, has following typical structure feature:
R wherein
1, R
2Be the structure of hydrocarbon chain or band phenyl ring, hydrocarbon chain or phenyl ring band side chain or be not with side chain, X is a halide ion.Typical material has: the derivative and the compound of alkyl dimethyl ammonium halide, two alkyl dimethyl ammonium halide, dodecylbenzyl alkyl dimethyl ammonium chloride, dodecyl benzyl dimethyl ammonium bromide, softex kw, two decyl alkyl dimethyl ammonium chloride, dodecyl dimethyl ammonium halide and these materials thereof.
3. composition according to claim 1, it is characterized in that described one or more cellulose esters thickeners are selected from the homopolymers and the copolymer of Hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose, propyl cellulose, hydroxypropyl cellulose or cellulose esters material.Described composition comprises the cellulose esters thickener or the cellulose esters mixtures of thickening agents of 0.01%-5% weight.
4. composition according to claim 1 is characterized in that, the preferred distilled water of described water, purified water or deionized water.
5. composition as claimed in claim 3 is characterized in that, the viscosity of described composition is 500-100,000cP.
6. composition according to claim 1 is characterized in that, the prescription of a typical composition is: 10% pair eight, two ten alkyl-dimethyl ammonium chlorides, 0.7% Hydroxypropyl methylcellulose, solvent are distilled water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810154396XA CN101502261A (en) | 2008-12-24 | 2008-12-24 | Stable thickening type quaternary ammonium salt composition |
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|---|---|---|---|
| CNA200810154396XA CN101502261A (en) | 2008-12-24 | 2008-12-24 | Stable thickening type quaternary ammonium salt composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101956027A (en) * | 2010-10-13 | 2011-01-26 | 四川大学 | Sheep fur with nanometer antibacterial function and preparation method thereof |
| GB2510042A (en) * | 2012-11-21 | 2014-07-23 | Henkel Ag & Co Kgaa | Highly viscous disinfectant composition |
| CN111096340A (en) * | 2019-12-02 | 2020-05-05 | 安徽启威生物科技有限公司 | Disinfectant concentrated solution for pet hospitals and preparation method thereof |
-
2008
- 2008-12-24 CN CNA200810154396XA patent/CN101502261A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101956027A (en) * | 2010-10-13 | 2011-01-26 | 四川大学 | Sheep fur with nanometer antibacterial function and preparation method thereof |
| CN101956027B (en) * | 2010-10-13 | 2013-06-05 | 四川大学 | Sheep fur with nanometer antibacterial function and preparation method thereof |
| GB2510042A (en) * | 2012-11-21 | 2014-07-23 | Henkel Ag & Co Kgaa | Highly viscous disinfectant composition |
| CN111096340A (en) * | 2019-12-02 | 2020-05-05 | 安徽启威生物科技有限公司 | Disinfectant concentrated solution for pet hospitals and preparation method thereof |
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Open date: 20090812 |