CN104873908A

CN104873908A - Traditional Chinese medicine for treating coronary heart disease with anxiety

Info

Publication number: CN104873908A
Application number: CN201510322423.XA
Authority: CN
Inventors: 李丽
Original assignee: Jinan Bangwen Pharmaceutical Technology Co Ltd
Current assignee: Jinan Bangwen Pharmaceutical Technology Co Ltd
Priority date: 2015-06-13
Filing date: 2015-06-13
Publication date: 2015-09-02

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine for treating coronary heart disease with anxiety. The traditional Chinese medicine for treating coronary heart disease with anxiety is prepared by the following raw materials: bupleurum root, pericarpium citri reticulatae viride, nutgrass galingale rhizome, Szechwan chinaberry fruit, bergamot, citron, rose, armeniaca mume, birthwor root, fructus aurantii, gardenia, bamboo leaves, lophatherum gracile, calcitum, prunella vulgaris, keel, magnetite, seed of wild jujube, cortex albiziae, polygonum multiflorum, corydalis tuber, rhizoma chuanxiong, radix curcumae, rhizoma curcumae longae, trogopterus dung, frankincense, myrrh, red sage root, safflower, peach kernel, lignum sappan, sanguis draconis, leech, tabanus, amd licorice. The traditional Chinese medicine for treating coronary heart disease with anxiety is high in both significant efficiency and effective efficiency; it improves anxiety while improves the syndrome of Chinese medicine of a patient, so that the electrocardiogram of the patient with coronary heart disease can be recovered to normal.

Description

A kind of Chinese medicine for the treatment of coronary heart disease companion anxiety

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of coronary heart disease companion anxiety.

Background technology

In Chinese medicine, coronary heart disease ranges the category of " thoracic obstruction ", " pained ", and normal in middle-aged and elderly people.Traditional view thinks that coronary heart disease is by long-term hyperpiesia, Hyperlipemia, the too high initiation of blood glucose, and modern medicine circle is generally admitted coronary heart disease and is not only a class body illness, and be the disease of a class impact psychology, the factor such as emotion and behavior also obviously have impact on morbidity and the progress of coronary heart disease.The morbidity of coronary heart disease is by the result of bio-psycho-social factors comprehensive function, and patient not only will stand the misery on health, also will bear complicated reaction at heart.

Anxiety (Anxiety) symptom is that one allows patient feel offending special emotion, the patient with anxiety symptom often with a kind of nervous emotion for feature do not conformed to very much with reality to treat actual life, this nervously do not have fixing object or content, and constantly.Anxiety state is one of affective state of the most often merging of coronary heart disease, and the development of the lasting anxiety state that exists and coronary heart disease is closely related.Patient shows as anxiety symptom on the one hand, shows as concrete physical symptom and vegetative nerve disease on the other hand.In domestic and international clinical statistics, the sickness rate of coronary heart disease companion anxiety symptom constantly increases, claim the internal medicine having 69% ~ 70.4% senile patients with coronary heart disease of being in hospital to occur together anxiety symptom according to relevant studies in China, foreign data statistics has 80% cardiac Care Unit patient to occur together anxiety symptom.And the anxiety sickness rate of normal population is far below patients with coronary heart disease.Coronary heart disease companion anxiety symptom patient often with Somatic discomfort and sleep disorder, have with autonomic nervous dysfunction, had a strong impact on ability to work and the efficiency of patient.Patient goes to a doctor repeatedly, not only adds burden and the medical expense of medical institutions, causes sizable economic pressures also to individual and country.

Current western medical treatment coronary heart disease companion anxiety symptom, mainly to the treatment of coronary heart disease, is aided with anxiolytic drugs.Although there is certain curative effect, anti-antipsychotics has the shortcomings such as side effect is large, expensive, and many medicines itself can cause the untoward reaction of cardiovascular system.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, a kind of Chinese medicine for the treatment of coronary heart disease companion anxiety is provided, this Chinese medicine is for improving the anxiety symptom of Coronary Heart Disease with Anxiety, there is obvious effective rate high, the advantage that effective percentage is high, while improving anxiety, improve the tcm syndrome of disease patient, make patients with coronary heart disease electrocardiogram recover normal.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for coronary heart disease companion anxiety, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Bupleuri 8-16 part, Pericarpium Citri Reticulatae Viride 6-14 part, Rhizoma Cyperi 8-16 part, Fructus Toosendan 6-14 part, Fructus Citri Sarcodactylis 6-14 part, Fructus Citri 6-14 part, Flos Rosae Rugosae 4-8 part, FLOS MUME 4-8 part, Radix Aristolochiae 6-14 part, Fructus Aurantii 8-16 part, Fructus Gardeniae 8-16 part, Folium Bambusae 11-19 part, Herba Lophatheri 8-16 part, Mirabilitum crystallina 8-16 part, Spica Prunellae 8-16 part, Os Draconis 11-19 part, Magnetitum 11-19 part, Semen Ziziphi Spinosae 8-16 part, Cortex Albiziae 16-24 part, Caulis Polygoni Multiflori 11-19 part, Rhizoma Corydalis 11-19 part, Rhizoma Chuanxiong 11-19 part, Radix Curcumae 8-16 part, Rhizoma Curcumae Longae 5-13 part, Oletum Trogopterori 6-14 part, Olibanum 5-13 part, Myrrha 5-13 part, Radix Salviae Miltiorrhizae 8-16 part, Flos Carthami 5-13 part, Semen Persicae 5-13 part, Lignum Sappan 5-13 part, Sanguis Draxonis 1-2 part, Hirudo 2-4 part, Tabanus 1-2 part, Radix Glycyrrhizae 5-13 part.

Preferably, the Chinese medicine of above-mentioned treatment coronary heart disease companion anxiety, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Bupleuri 10-14 part, Pericarpium Citri Reticulatae Viride 8-12 part, Rhizoma Cyperi 10-14 part, Fructus Toosendan 8-12 part, Fructus Citri Sarcodactylis 8-12 part, Fructus Citri 8-12 part, Flos Rosae Rugosae 5-7 part, FLOS MUME 5-7 part, Radix Aristolochiae 8-12 part, Fructus Aurantii 10-14 part, Fructus Gardeniae 10-14 part, Folium Bambusae 13-17 part, Herba Lophatheri 10-14 part, Mirabilitum crystallina 10-14 part, Spica Prunellae 10-14 part, Os Draconis 13-17 part, Magnetitum 13-17 part, Semen Ziziphi Spinosae 10-14 part, Cortex Albiziae 18-22 part, Caulis Polygoni Multiflori 13-17 part, Rhizoma Corydalis 13-17 part, Rhizoma Chuanxiong 13-17 part, Radix Curcumae 10-14 part, Rhizoma Curcumae Longae 7-11 part, Oletum Trogopterori 8-12 part, Olibanum 7-11 part, Myrrha 7-11 part, Radix Salviae Miltiorrhizae 10-14 part, Flos Carthami 7-11 part, Semen Persicae 7-11 part, Lignum Sappan 7-11 part, Sanguis Draxonis 1.2-1.8 part, Hirudo 2.5-3.5 part, Tabanus 1.2-1.8 part, Radix Glycyrrhizae 7-11 part.

Preferred, the Chinese medicine of above-mentioned treatment coronary heart disease companion anxiety, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Bupleuri 12 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi 12 parts, Fructus Toosendan 10 parts, Fructus Citri Sarcodactylis 10 parts, Fructus Citri 10 parts, Flos Rosae Rugosae 6 parts, FLOS MUME 6 parts, Radix Aristolochiae 10 parts, Fructus Aurantii 12 parts, Fructus Gardeniae 12 parts, 15 parts, Folium Bambusae, Herba Lophatheri 12 parts, Mirabilitum crystallina 12 parts, Spica Prunellae 12 parts, Os Draconis 15 parts, Magnetitum 15 parts, Semen Ziziphi Spinosae 12 parts, Cortex Albiziae 20 parts, Caulis Polygoni Multiflori 15 parts, Rhizoma Corydalis 15 parts, Rhizoma Chuanxiong 15 parts, Radix Curcumae 12 parts, 9 parts, Rhizoma Curcumae Longae, Oletum Trogopterori 10 parts, Olibanum 9 parts, Myrrha 9 parts, Radix Salviae Miltiorrhizae 12 parts, 9 parts, Flos Carthami, 9 parts, Semen Persicae, Lignum Sappan 9 parts, Sanguis Draxonis 1.5 parts, Hirudo 3 parts, Tabanus 1.5 parts, 9 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of coronary heart disease companion anxiety.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In the clinical observation of Cardiological, patients with coronary heart disease is clinical manifestation usually with generalized anxiety disorder: often with a kind of nervous emotion for feature do not conformed to very much with reality to treat actual life, this nervously do not have fixing object or content, and constantly.A kind of pathological state like this allows patient be difficult to break away from; Normal hyperfunction with vegetative nervous function, nervousness in sports is with undue vigilant.The patient of generalized anxiety disorder usually shows the local discomforts such as chest presses and nervous, tachypnea, pale complexion, perspiration, frequent micturition clinically, is afraid of cold, similar to the symptom of coronary heart disease.Coronary heart disease is accompanied anxiety symptom mainly with somatization and mental symptom and is seen.Somatization comprises: uncomfortable in chest, chest pain, fullness and distention in the chest and hypochondrium, have a dizzy spell, the dark red tongue of bitter taste in the mouth and dry throat, yellowish or reddish urine, constipation, tongue is white or yellow, stringy pulse or stringy and rapid pulse; Mental symptom comprises: anxiety, vexed irritability, insomnia and dreamful sleep.

Coronary heart disease companion anxiety symptom site of pathological change is mainly at the heart, relevant with liver spleen kidney.Simulataneous insufficiency and excessive is its pathologic feature, and dialectical from void is negative and positive of qi and blood virtual loss: ponder over and not saving, cause deficiency of the spleen causing weakness of QI, lack of preservation of spirit; The loss of the moon blood, liver-blood deficiency, the heart is become homeless foster, irritability imbalance or excessive rising of liver-YANG, then hide soul uneasiness, appended by god's nothing; Deficiency of liver-blood is courage virtual loss then, resolution mistake department; Feelings will is forfeited one's integrity, it is excessive to be worried, then the loss motive, can cause courage virtual loss; If cloudy essence consumption wound, can involve all internal organs of heart kidney liver and gall, the moon sun not processed, deficiency-fire stirring up, the mind disturbed by fire.From real dialectical for expectorant is turbid, blood stasis, the stagnation of QI hinder in meridians."Nei Jing" has cloud: " anxiety making QI depressed ... excessive fright leading to disturbance of QI ... the frightened then heart, without complied with, is considered and determine without institute, god's nothing returned ", has set forth disorder of movement of QI and has had a strong impact on the generation of primary disease and lapsed to.In addition, the physiological function of liver is main catharsis, and liver person belongs to wood, wood characterized by bending and straightening, and happiness tune reaches and dislikes depression, and department's feelings will regulates; It is inappropriate that the reason of depression of liver-QI mostly is feelings will, and for some reason, many scholars inquire into the main pathogenesis that " liver-disorder of movement of QI-anxiety " is primary disease.Theory has: ponder over and not saving, and insufficiency of the spleen wood is weak, and catharsis is not enough, functional activity of QI being not smooth, and stagnation of liver-QI is fire-transformation with the passing of time, upsets the mind; Depression of liver-QI, wooden strongly fragrant insult spleen, transporting mistake department, Tianjin is coagulated for expectorant, stagnation of Qi and phelgm, blocks sering, lack of preservation of spirit; Melancholy with the passing of time, depression of liver-QI, catharsis mistake department, qi-movement disturbance, with the passing of time fire-transformation, refining liquid is expectorant, and expectorant, heat, strongly fragrant mutual knot, hoodwink the mind; Be worried for a long time, depression of liver-QI, stagnation of QI sering, changed raw blood stasis, stasis of blood fire-transformation of a specified duration, follow through on disturb, malaise.As can be seen here, depression of liver-QI can cause anxiety, and in addition, excessive rising of liver-YANG, liver-wind stirring up internally, also can the disturbance mind, causes the generation of anxiety.Liver department feelings will, liver and gall are the exterior and the interior each other, and has cloud in " the secret allusion quotation opinion of Plain Questions LINGLAN ": " gallbladder person; fu-viscera with decisive character; make a decision and here ", illustrates that gallbladder internal organs can prevent extraneous excessive direct stimulation under normal physiological function, keeps the normal coordination of body negative and positive of qi and blood and other function.Easily there is anxiety in gerontal patient, because its function void declines, easily by the stimulation of external environment, abnormal emotion.Internal organs void declines, asthenia of cholic qi, and failure of stomach-QI to descend is superinverse on the contrary, and water paddy is become thoroughly decomposed Yun Hua mistake department, and spleen deficiency generating phlegm, expectorant coagulates heat-transformation, combination of phlegm and heat, qi-movement disturbance.This cause of disease, because function is not normal, has again external environment to stimulate, gallbladder discomfort in the stomach, expectorant Re Neisheng, the disturbance mind, loses resolution ability.Heresy enters few sun, depression of liver-QI, and gallbladder internal organs is hot and suffocating, upsets the generation that the mind also can cause primary disease

Depression of liver-QI, the important morbidity link that the mind is anxiety disturbed by fire.Coronary heart disease merges anxiety generally from disorder of movement of QI, and people has life, entirely relies in gas, QI movement being in harmonious way under normal condition, ascending, descending, exiting and entering harmonious orderly, and body normally could play every physiological function, and internal organs could keep normally orderly functional activity.With the passing of time and heat-transformation is lit a fire, wood generating fire, liver heart mothers and sons each other under pathological state, disorder of movement of QI, ascending, descending, exiting and entering mistake department, depression of liver-QI, the liver heart communicates, liver-fire priming heart-fire, fire characterized by flaring up, and the mind disturbed by fire.Not only there is the pathological changes of depression of liver-QI in patient, as feeling of oppression and pain in the chest, fullness and distention in the chest and hypochondrium, bitter taste in the mouth and dry throat, the symptom such as to have a dizzy spell, mind aspect symptom disturbed by the fire such as clinical more visible vexed irritability, insomnia and dreamful sleep.The record that "Nei Jing" has " melancholy is feared indignation and felt frustrated ", thinks that five will are crossed and then feel frustrated.Have cloud in " Zhengzi Huibu melancholia ": " though melancholia is many, all because gas is not circulated, method when pleasant be first ", propose from gas by controlling.Clinical treatment melancholia, is first depressed liver-energy dispersing and QI regulating, liver controlling conveyance and dispersion, harmonizing the functional activities of vital QI, therefore treating the liver is and controls gas.On pathogenesis, feelings will does not save and causes the stagnation of QI, and the stagnation of QI is functional activity of QI being not smooth then, and causes suffocating of liver and gall mistake department, and then causes his dirty all diseases by the liver change of disease.The wet food of QI and blood phlegm-fire, the stagnation of QI is the beginning of six kinds of stagnation-syndromes, therefore, controls Yu Shouxian and is soothing the liver, to declare smooth few sun for principle, dispersing the stagnated live-QI to relieve the stagnation of QI, harmonizing the functional activities of vital QI.

The basic pathogenesis of coronary heart disease companion anxiety is depression of liver-QI, and qi depression to blood stasis, the strongly fragrant mutual knot of QI and blood, heat-transformation is lit a fire, and the mind disturbed by fire.Sick position is mainly dirty at the liver heart two.Liver and the heart in close relations.The heart matches fire, the liver belonging to wood, wood generating fire, liver heart mothers and sons each other; The main blood of the heart and house mind, blood stored in the liver and give up soul.The physiology contact of the two is mainly manifested in blood operation and mind two aspect.Cloud is had: " blood vessels and profit, spirit is occupy " in " the exhausted paddy section of Ling Shu Miraculous Pivot or Divine Axis normal person ".Through cloud: " soothing the stagnant liver is also, right blood stored in the liver, and sleeping then blood is attributed to liver at nightfall, is that foster person's blood is rely also in the institute of liver." because the main pathogenesis of coronary heart disease and the traditional Chinese medical science thoracic obstruction and pathological product to be cold coagulation, the stagnation of QI, blood stasis, expectorant turbid.The general character of these pathological factors or pathological product can affect mechanism of qi, liver controlling conveyance and dispersion, harmonizing emotions, the normal performance of liver controlling conveyance and dispersion function needs the normal of the ascending, descending, exiting and entering function of gas, and when the pathological product impatency mechanism of qi such as cold coagulation, blood stasis, expectorant is turbid, the catharsis function of liver will be not normal, disorder of movement of QI, depression of liver-QI, heat-transformation is lit a fire, liver heart mothers and sons each other, its gas phase is led to, liver-fire priming heart-fire, fire characterized by flaring up, causes clinical appearance fire to disturb the symptom of the mind.So the method for the treatment of of coronary heart disease companion anxiety is that resolving depression is invigorated blood circulation, clearing away heart-fire for tranquillization method.

The Chinese prescription mechanism for the treatment of coronary heart disease companion anxiety of the present invention is as follows:

Radix Bupleuri, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi, Fructus Toosendan, Fructus Citri Sarcodactylis, Fructus Citri, Flos Rosae Rugosae, FLOS MUME, Radix Aristolochiae, Fructus Aurantii merit are with dispersing the stagnated live-QI to relieve the stagnation of QI, and fluent mechanism of qi is monarch drug altogether; Rhizoma Corydalis, Rhizoma Chuanxiong, Radix Curcumae, Rhizoma Curcumae Longae, Oletum Trogopterori, Olibanum, Myrrha, Radix Salviae Miltiorrhizae, Flos Carthami, Semen Persicae, Lignum Sappan, Sanguis Draxonis, Hirudo, Tabanus merit with blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain; Fructus Gardeniae, Folium Bambusae, Herba Lophatheri, Mirabilitum crystallina, Spica Prunellae merit are with clearing heat and relieving fidgetness; Os Draconis, Magnetitum, Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori merit are with calm tranquilizing by nourishing the heart; Be adjuvant drug altogether; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making medicine.We's compatibility is reasonable, and all medicines what with playing dispersing the stagnated live-QI to relieve the stagnation of QI, promoting blood circulation to remove obstruction in the collateral altogether, the effect of clearing away heart-fire for tranquillization, and the pathogen and pathology of tcm of the coronary heart disease that links closely companion anxiety symptom patient, achieves good clinical efficacy.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine for coronary heart disease companion anxiety, each crude drug weight proportion is as follows:

Radix Bupleuri 12g, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Cyperi 12g, Fructus Toosendan 10g, Fructus Citri Sarcodactylis 10g, Fructus Citri 10g, Flos Rosae Rugosae 6g, FLOS MUME 6g, Radix Aristolochiae 10g, Fructus Aurantii 12g, Fructus Gardeniae 12g, Folium Bambusae 15g, Herba Lophatheri 12g, Mirabilitum crystallina 12g, Spica Prunellae 12g, Os Draconis 15g, Magnetitum 15g, Semen Ziziphi Spinosae 12g, Cortex Albiziae 20g, Caulis Polygoni Multiflori 15g, Rhizoma Corydalis 15g, Rhizoma Chuanxiong 15g, Radix Curcumae 12g, Rhizoma Curcumae Longae 9g, Oletum Trogopterori 10g, Olibanum 9g, Myrrha 9g, Radix Salviae Miltiorrhizae 12g, Flos Carthami 9g, Semen Persicae 9g, Lignum Sappan 9g, Sanguis Draxonis 1.5g, Hirudo 3g, Tabanus 1.5g, Radix Glycyrrhizae 9g.

Embodiment 2

Radix Bupleuri 10g, Pericarpium Citri Reticulatae Viride 12g, Rhizoma Cyperi 10g, Fructus Toosendan 12g, Fructus Citri Sarcodactylis 8g, Fructus Citri 12g, Flos Rosae Rugosae 5g, FLOS MUME 7g, Radix Aristolochiae 8g, Fructus Aurantii 14g, Fructus Gardeniae 10g, Folium Bambusae 17g, Herba Lophatheri 10g, Mirabilitum crystallina 14g, Spica Prunellae 10g, Os Draconis 17g, Magnetitum 13g, Semen Ziziphi Spinosae 14g, Cortex Albiziae 18g, Caulis Polygoni Multiflori 17g, Rhizoma Corydalis 13g, Rhizoma Chuanxiong 17g, Radix Curcumae 10g, Rhizoma Curcumae Longae 11g, Oletum Trogopterori 8g, Olibanum 11g, Myrrha 7g, Radix Salviae Miltiorrhizae 14g, Flos Carthami 7g, Semen Persicae 11g, Lignum Sappan 7g, Sanguis Draxonis 1.8g, Hirudo 2.5g, Tabanus 1.8g, Radix Glycyrrhizae 7g.

Embodiment 3

Radix Bupleuri 14g, Pericarpium Citri Reticulatae Viride 8g, Rhizoma Cyperi 14g, Fructus Toosendan 8g, Fructus Citri Sarcodactylis 12g, Fructus Citri 8g, Flos Rosae Rugosae 7g, FLOS MUME 5g, Radix Aristolochiae 12g, Fructus Aurantii 10g, Fructus Gardeniae 14g, Folium Bambusae 13g, Herba Lophatheri 14g, Mirabilitum crystallina 10g, Spica Prunellae 14g, Os Draconis 13g, Magnetitum 17g, Semen Ziziphi Spinosae 10g, Cortex Albiziae 22g, Caulis Polygoni Multiflori 13g, Rhizoma Corydalis 17g, Rhizoma Chuanxiong 13g, Radix Curcumae 14g, Rhizoma Curcumae Longae 7g, Oletum Trogopterori 12g, Olibanum 7g, Myrrha 11g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 11g, Semen Persicae 7g, Lignum Sappan 11g, Sanguis Draxonis 1.2g, Hirudo 3.5g, Tabanus 1.2g, Radix Glycyrrhizae 11g.

Embodiment 4

Radix Bupleuri 8g, Pericarpium Citri Reticulatae Viride 14g, Rhizoma Cyperi 8g, Fructus Toosendan 14g, Fructus Citri Sarcodactylis 6g, Fructus Citri 14g, Flos Rosae Rugosae 4g, FLOS MUME 8g, Radix Aristolochiae 6g, Fructus Aurantii 16g, Fructus Gardeniae 8g, Folium Bambusae 19g, Herba Lophatheri 8g, Mirabilitum crystallina 16g, Spica Prunellae 8g, Os Draconis 19g, Magnetitum 11g, Semen Ziziphi Spinosae 16g, Cortex Albiziae 16g, Caulis Polygoni Multiflori 19g, Rhizoma Corydalis 11g, Rhizoma Chuanxiong 19g, Radix Curcumae 8g, Rhizoma Curcumae Longae 13g, Oletum Trogopterori 6g, Olibanum 13g, Myrrha 5g, Radix Salviae Miltiorrhizae 16g, Flos Carthami 5g, Semen Persicae 13g, Lignum Sappan 5g, Sanguis Draxonis 2g, Hirudo 2g, Tabanus 2g, Radix Glycyrrhizae 5g.

Embodiment 5

Radix Bupleuri 16g, Pericarpium Citri Reticulatae Viride 6g, Rhizoma Cyperi 16g, Fructus Toosendan 6g, Fructus Citri Sarcodactylis 14g, Fructus Citri 6g, Flos Rosae Rugosae 8g, FLOS MUME 4g, Radix Aristolochiae 14g, Fructus Aurantii 8g, Fructus Gardeniae 16g, Folium Bambusae 11g, Herba Lophatheri 16g, Mirabilitum crystallina 8g, Spica Prunellae 16g, Os Draconis 11g, Magnetitum 19g, Semen Ziziphi Spinosae 8g, Cortex Albiziae 24g, Caulis Polygoni Multiflori 11g, Rhizoma Corydalis 19g, Rhizoma Chuanxiong 11g, Radix Curcumae 16g, Rhizoma Curcumae Longae 5g, Oletum Trogopterori 14g, Olibanum 5g, Myrrha 13g, Radix Salviae Miltiorrhizae 8g, Flos Carthami 13g, Semen Persicae 5g, Lignum Sappan 13g, Sanguis Draxonis 1g, Hirudo 4g, Tabanus 1g, Radix Glycyrrhizae 13g.

Carried out clinical pharrnacokinetics test to the Chinese medicine of embodiments of the invention l, Details as Follows:

Choose coronary heart disease and merge anxiety patient 100 example.

(1) western medicine diagnostic criteria

1. diagnostic criteria for coronary heart disease

With reference to " the coronary atherosclerotic heart disease diagnostic criteria " of Ministry of Health of the People's Republic of China's issue in 2010, wherein angina pectoris comprises stable angina pectoris and unstable angina pectoris, and myocardial infarction comprises non-ST section Elevation Myocardial Infarction and ST section Elevation Myocardial Infarction.

(1) stable angina pectoris (SA): anginal attack times, inducement, outbreak character and position are relatively stable in 1 month ~ 3 months.1. the Episodes of classical angina symptom, in conjunction with the cardiovascular risk factors that patient exists, the chest pain except caused by other reasons; 2. have electrocardiogram ischemic ST-T dynamically to change during episode, or the ECG exercise test positive change.Electrocardioscopy during outbreak is if find that based in the leading of R ripple, ST section moves down, and T ripple is low flat or be inverted, and can recuperator contribute to establishing and diagnoses gradually after remission.

According to Canadian cardiovascular association (CCS) angina pectoris Severity gradation.I grade: general physical exertion can not cause angina pectoris attacks.Such as level walking and going upstairs, but nervous, quick or lasting firmly can cause angina pectoris attacks.II grade: daily routines are restricted a little.Quick level walking or go upstairs, ascend a height, walk after the meal or go upstairs, cold or walk in contrary wind, excitedly cause angina pectoris attacks, or only to show effect in several hours after wakeing up.At nominal conditions with usual speed level land walking more than 200 meters or to climb up the stair of more than one deck limited.III grade: daily physical work is significantly limited, at nominal conditions with usual speed level walking 100 meters ~ 200 meters or step on one deck stair and can cause angina pectoris attacks.IV grade: when light activity or rest, can angina pectoris attacks be caused.

(2) non-ST section elevation acute coronary syndrome (NSTE-ACS): the 1. clinical manifestation such as typical Ischemic Chest Pain; 2. typical ECG alteration (kainogenesis or transient ST section Xia Yi≤0.1mV, or T ripple inversion >=0.2mV); If 3. cardiac marker cTnT, cTnI(TnT, Troponin I) or CK-MB(creatine kinase isozyme) level rising, NSTEMI can be diagnosed, if label level does not have overrun to be diagnosed as unstable angina pectoris (UA).

UA has following clinical manifestation: 1. silent Angina Pectoris: angina pectoris attacks is when rest, persistent period, usually more than 20 minutes, comprising ariant angina, is generally spontaneous, be characterized in that Electrocardiogram Feature is that transient ST section is raised, majority can spontaneous remission; 2. onset angina pectoris: angor of newly making up one's mind in 1 month, can show as spontaneous seizure and labour's property is shown effect and deposits; 3. worsen effort angina: have angina pectoris attacks history of past illness, in nearest 1 month, angina pectoris attack degree increases the weight of, and attack times is frequent, duration of seizure extends or the threshold of pain reduces.

(3) ST section elevation acute myocardial infarction (STEMI): have at least myocardial injury markers (cTnT, a cTnI or CK-MB) typical case to increase to over Upper Limit of Normal Value, simultaneously at least with in following situation, i.e. diagnosable STEMI.1. myocardial ischemia symptom; 2. prompting has the new Electrocardiogram Feature (the ST-T performance of new or the new left bundle branch block sent out) sending out ischemia; 3. there is pathologic Q ripple in electrocardiogram; The radiological evidence of the Abnormal Wall Motion 4. having the new survival myocardium sent out to lose or newly to send out.

2. the diagnostic criteria of anxiety

With reference to the anxiety state of " Chinese Spirit classification of diseases scheme and diagnostic criteria the 3rd edition (CCMD-3) ", and Hamilton anxiety scale (HAMA) is marked >=14 existence assigning to determine anxiety symptom.Hamilton anxiety scale (HAMA) standards of grading:

< 7 points, without anxiety;

>=7 points, anxiety may be had;

>=14 points, certainly there is anxiety;

>=21 points, obviously there is anxiety;

>=29 points, seriously there is anxiety.

(2) Chinese medicine diagnostic criteria

1. Standards of Chinese Medical Syndrome Differentiation

Traditional Chinese medical science depression of liver-QI, mind syndrome diagnostic criterion disturbed by fire: " the new Chinese medicine treatment coronary heart disease guideline of clinical investigations " and " Chinese Internal Medicine " developed and published with reference to Ministry of Health of the People's Republic of China is formulated.

(1) clinical manifestation

Primary symptom: uncomfortable in chest, chest pain.

Hold concurrently disease: fullness and distention in the chest and hypochondrium, have a dizzy spell, vexed irritability, bitter taste in the mouth and dry throat, insomnia and dreamful sleep, yellowish or reddish urine, stool

The dark red tongue of constipated, tongue is white or yellow.

(2) pulse condition: string or stringy and rapid pulse.

Possess primary symptom and time disease 2 and more than, in conjunction with tongue arteries and veins.

2. tcm symptom scoring method, with reference to " new Chinese medicine treatment coronary heart disease guideline of clinical investigations ".

(3) case inclusive criteria

1. meet doctor trained in Western medicine diagnostic criteria for coronary heart disease person;

2. meet traditional Chinese medical science depression of liver-QI, the CM syndrome differentiation criterion of mind card disturbed by fire;

3. anxiety symptom symptom is obvious, Hamilton anxiety scale (HAMA) scoring >=14 points of persons;

4. the age was at 35-85 years old, and gender does not limit;

5. vital sign is steady, has certain ability to express;

6. do not take other anxiolytic drugs person in nearly two weeks;

7. sign patient's Informed Consent Form person.

The patient simultaneously meeting above-mentioned seven can be selected in.

(4) exclusion standard

1. do not meet Western medicine diagnose standard or Standards of Chinese Medical Syndrome Differentiation person.

2. be diagnosed as on inspection other great heart diseases (as congenital heart disease, serious valvular heart disease,

Pulmonary heart disease etc.), serious somatoform disorder, serious perimenopausal syndrome, hyperthyroidism, digestion

The chest pain person caused by other diseases such as systemic disease.

3. merge serious hypertension (apoplexy etc.), cardiac insufficiency, arrhythmia person, or liver, kidney, to make

The severe primary diseases such as blood system, psychotic.

4. take the withdrawal symptom after excited class overdose, calm class medicine or antianxiety drugs, other divides as spirit

Split the anxiety that the mental sickness such as disease, obsession, phobia, hypochondria, neurasthenia, mania occur together.

5. gestation or women breast-feeding their children.

6. allergic constitution and to multi-medicament allergy sufferers.

7. do not meet inclusive criteria, not by regulation medication, curative effect cannot be judged or state of an illness data is not congruent affects the treatment

Or safety judgement person.

Meet above-mentioned wherein one namely give eliminating.

Therapeutic Method

100 routine patients all give Chinese medicine resolving depression and to clear away heart-fire Huoxue Decoction.

Prescription is as follows: Radix Bupleuri 12g, Pericarpium Citri Reticulatae Viride 10g, Rhizoma Cyperi 12g, Fructus Toosendan 10g, Fructus Citri Sarcodactylis 10g, Fructus Citri 10g, Flos Rosae Rugosae 6g, FLOS MUME 6g, Radix Aristolochiae 10g, Fructus Aurantii 12g, Fructus Gardeniae 12g, Folium Bambusae 15g, Herba Lophatheri 12g, Mirabilitum crystallina 12g, Spica Prunellae 12g, Os Draconis 15g(is decocted first), Magnetitum 15g(smashes and is decocted first), Semen Ziziphi Spinosae 12g, Cortex Albiziae 20g, Caulis Polygoni Multiflori 15g, Rhizoma Corydalis 15g, Rhizoma Chuanxiong 15g, Radix Curcumae 12g, Rhizoma Curcumae Longae 9g, Oletum Trogopterori 10g, Olibanum 9g, Myrrha 9g, Radix Salviae Miltiorrhizae 12g, Flos Carthami 9g, Semen Persicae 9g, Lignum Sappan 9g, Sanguis Draxonis 1.5g(grinds into powder and takes after mixing it with water), Hirudo 3g, Tabanus 1.5g, Radix Glycyrrhizae 9g, be decocted in water for oral dose, every day potion, each 150ml, 2 times/d.

(2) observation item and index

1. safety indexes:

(1) general inspection project (temperature pulse respiration, blood pressure);

(2) blood, urine, stool routine inspection;

(3) Liver and kidney function inspection;

(4) Electrocardioscopy.

Above index respectively measures once respectively at (4 weeks) after (0 week) before treatment and treatment.

2. health giving quality is observed

(1) change of tcm clinical practice Symptoms and tongue fur, pulse condition:

Observe the sings and symptoms that coronary heart disease companion anxiety is common, and respectively at after (0 week), treatment before treatment (4 weeks)

Inquire item by item and note down, giving to judge score by symptom standard, every routine sample symptom score sum is this sample syndrome

Total mark value.

(2) evaluation of anxiety symptom

In strict accordance with the regulation of Hamilton anxiety scale (HAMA), by two medicos through training to patient

Carry out joint inspection.The time range of evaluation is at that time or enters to organize the situation of the last week, (0 week), treatment before treatment

(4 weeks) respectively evaluate once afterwards.

(3) Electrocardioscopy

Before treatment, (0 week), rear (4 weeks) are respectively recorded once

3. curative effect determinate standard

(1) tcm syndrome curative effect determinate standard

Cure: clinical symptoms, sign disappear, therapeutic index (n) >=95%.

Effective: clinical symptoms, sign are obviously improved, therapeutic index (n) >=70%.

Effective: clinical symptoms, sign all take a favorable turn, therapeutic index (n) >=30%.

Invalid: clinical symptoms, sign are not improved, even increase the weight of, therapeutic index (n) < 30%.

Increase the weight of: clinical symptoms, sign all have and increase the weight of, therapeutic index (n) < 0.

The front integration x100% of integration/treatment after integration-treatment before therapeutic index (n)=treatment

(2) main hypertensive TCM disease is observed

Main hypertensive TCM disease: uncomfortable in chest, chest pain, fullness and distention in the chest and hypochondrium, have a dizzy spell, 11 symptoms such as the dark red tongue of vexed irritability, bitter taste in the mouth and dry throat, insomnia and dreamful sleep, yellowish or reddish urine, constipation, tongue is white or yellow, pulse condition string or stringy and rapid pulse.

(3) anxiety symptom the standard of curative effect evaluation

The front integration x100% of integration/treatment after integration-treatment before the rate=treatment of HAMA deduction

Cure: HAMA Manifest Anxiety Scale deduction rate >=95%.

Effective: HAMA Manifest Anxiety Scale scoring < 7 or deduction rate >=50%.

Effective: HAMA Manifest Anxiety Scale scoring deduction rate >=25%.

Invalid: HAMA Manifest Anxiety Scale scoring deduction rate < 25%.

Increase the weight of: increase before the scoring comparatively of HAMA Manifest Anxiety Scale.

(4) ECG curative effect criterion

Effective: electrocardiogram returns to " roughly normal ECG " (i.e. " electrocardiogram normal range ") from pathological state or reaches " normal ECG " standard.

Effective: former electrocardiogram is abnormal electrocardiographic pattern, ST section decreases beyond 0.05mV, through treatment ST section more than rise 0.05mV, but not yet reach electrocardiogram level normal range, the T ripple mainly led becomes shallow inversion (change amplitude reaches more than 25% person) from the dark inversion before treating; Or T ripple is become upright from low flat before treating, atrioventricular block or intraventricular block are improved before comparing treatment.

Invalid: electrocardiogram is substantially identical with before treatment.

Increase the weight of: former electrocardiogram is abnormal electrocardiographic pattern, ST section decreases beyond 0.05mV, more than 0.05mV is reduced before treatment ST section is comparatively treated, it is smooth from uprightly becoming before treating that the T ripple mainly led becomes dark inversion (change amplitude reaches more than 25% person) or T ripple from the shallow inversion before treating, become inversion from smooth, and occur that ectopia cordis is beaten, atrioventricular block or intraventricular block person.

(3) statistical procedures

The data obtained carries out statistical analysis with statistics software SPSS for windows 17.0, and measurement data adopts t

Inspection, enumeration data adopts X 2 test, ranked data rank test.

Therapeutic outcome

1. HAMA change and curative effect before and after treatment

Before 100 routine patient treatments, average HAMA is (37.43 ± 4.87) point, and drop to after treatment (7.12 ± 1.24) point, difference has statistical significance (P<0.05).HAMA curative effect is in table 1

Table 1 HAMA curative effect

Number of cases

Cure

Effective

Effectively

Invalid

Cure rate

Obvious effective rate

Effective percentage

100 examples

20 examples

70 examples

10 examples

0 example

20（20.0%）

90（90%）

100（100%）

2. before and after treatment, TCM syndrome scoring is compared

Before 100 routine patient treatments, average TCM syndrome integration is (42.13 ± 4.22) point, and drop to after treatment (6.43 ± 1.15) point, difference has statistical significance (P<0.05).Tcm syndrome curative effect is in table 2

Table 2 tcm syndrome curative effect

Number of cases

Cure

Effective

Effectively

Invalid

Cure rate

Obvious effective rate

Effective percentage

100 examples

23 examples

71 examples

6 examples

0 example

23（23.0%）

94（94.0%）

100（100.0%）

3. ECG curative effect is in table 3

Table 3 ECG curative effect

Number of cases	Effective	Effectively	Invalid	Obvious effective rate	Effective percentage
						100 examples	52 examples	46 examples	2 examples	52（52.0%）	96（96.0%）

4. analysis of adverse reactions

In therapeutic process, patient does not all tell uncomfortable situation, has no obvious adverse reaction.Before and after treatment, blood, urine, stool routine and Liver and kidney function detect and are showed no exception.

Claims

1. treat a Chinese medicine for coronary heart disease companion anxiety, be made up of the raw material of Chinese medicine medicine of following weight portion:

2. the Chinese medicine for the treatment of coronary heart disease companion anxiety according to claim 1, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion:

3. the Chinese medicine for the treatment of treatment coronary heart disease companion anxiety according to claim 2, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion: