CN104856969A - Buccal tablet for treating oral ulcer - Google Patents
Buccal tablet for treating oral ulcer Download PDFInfo
- Publication number
- CN104856969A CN104856969A CN201510307630.8A CN201510307630A CN104856969A CN 104856969 A CN104856969 A CN 104856969A CN 201510307630 A CN201510307630 A CN 201510307630A CN 104856969 A CN104856969 A CN 104856969A
- Authority
- CN
- China
- Prior art keywords
- buccal tablet
- oral ulcer
- treatment
- gel
- ulcer according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a buccal tablet for treating oral ulcer. Oral ulcer is a common disease and a frequently-occurring disease, and the ulcer surface of oral ulcer is easily infected. According to a traditional method for preventing or treating wound injection, mouth wash, spray, a wound smearing agent, a wound adhesive and the like are mainly adopted, so that problems of short medical effect, mouth mucosa damage, poor comfort and the like exist. The buccal tablet is of a sheet structure, hydrophilic and water-insoluble gel serves as a matrix of the buccal tablet, and the buccal tablet contains an antibacterial agent which is contained in the gel, and the gel internally contains a support framework. The buccal tablet is orally taken or adhered to an oral ulcer part.
Description
technical field:
the present invention relates to a kind of buccal tablet being used for the treatment of oral ulcer.
background technology:
oral ulcer is commonly encountered diseases, frequently-occurring disease, and its ulcer surface very easily infects.Tradition prevention or treatment traumatic infection mainly adopt collutory, spray, wound surface smearing agent, wound surface to paste agent etc., and wherein wound surface smearing agent comprises common liniment and has adhering liniment.Oral cavity is moistening environment, constantly there is salivation, this can make the medicine being applied to wound surface as collutory, spray, common liniments etc. only have very short residence time, and oral cavity is the good environment of various microbial growth, this just makes the therapeutic effect of this kind of preparation limited, although although adhering liniment and paste agent and can play therapeutical effect for a long time, but the inner surface in oral cavity is mucosa, use adhering liniment at mucomembranous surface and paste agent and easily damage mucosa, form new ulcer, simultaneously, mucosa use adhering preparation sense of discomfort strong.
the object of this invention is to provide a kind of effective drug duration long, comfortable, to the undamaged buccal tablet being used for the treatment of oral ulcer of oral mucosa.
above-mentioned object is realized by following technical scheme:
be used for the treatment of a buccal tablet for oral ulcer, described buccal tablet is laminated structure, and its substrate is hydrophilic and water-insoluble gel, and described buccal tablet contains antibacterial, and described antibacterial is comprised in the inside of described gel, and supportive skeleton is contained in the inside of described gel.
the described buccal tablet being used for the treatment of oral ulcer, described buccal tablet is connected with paster, and the back side of described paster is binding agent, and the two ends, front of described paster are with annular casing, and described buccal tablet is positioned at the annular casing at described paster two ends.
the described buccal tablet being used for the treatment of oral ulcer, described hydrophilic and water-insoluble gel are cross-linked polyacrylamide, one composition in cross-linked sodium polyacrylate, starch grafted polyacrylamide, SANWET, cellulose graft polyacrylamide, cellulose graft sodium polyacrylate, poly hydroxy ethyl acrylate, cross-linked poly-methyl methacrylate hydroxyl ethyl ester or several copolymerization form.
the described buccal tablet being used for the treatment of oral ulcer, described supportive skeleton is that one or more in sponge, fiber, fabric, thin film mix.
the described buccal tablet being used for the treatment of oral ulcer, described antibacterial is that one or more in antibiotic, disinfectant mix.
the described buccal tablet being used for the treatment of oral ulcer, described antibacterial is slow releasing preparation, and described slow releasing preparation is the one or more combination in sustained-release micro-spheres, slow-release fiber, sustained release sponge, sustained release film.
the described buccal tablet being used for the treatment of oral ulcer, described buccal tablet is dry body, preferred lyophilizing.
the described buccal tablet being used for the treatment of oral ulcer, described slow releasing preparation uses as supportive skeleton simultaneously.
the described buccal tablet being used for the treatment of oral ulcer, described binding agent is adhesive of medical.
the described buccal tablet being used for the treatment of oral ulcer, described buccal tablet thickness is 0.5 millimeter-10 millimeters.Beneficial effect:
1. buccal tablet in the present invention adopt hydrophilic and water-insoluble gel as substrate, molecular structure due to adopted gel is tridimensional network, tridimensional network can keep gel not dissolve, do not degrade, make outward appearance simultaneously, shape, size in use remains unchanged substantially, moisture and medicine free diffusing can be made simultaneously, thus make medicine be easy to act on wound, and there is strong hydrophilic, moisture in gel absorption saliva becomes water saturation state, soft after water saturation, smooth surface, inviscid, nonirritant and there is water lubrication effect, therefore it is NA for contacting with skin or oral mucosa, greatly can strengthen the comfortableness of use.
in the present invention, buccal tablet has slow releasing function, can control the dissolution rate of medicine, thus reaches the long-time effect playing drug effect.
buccal tablet in the present invention both can be used alone, also can with paster with the use of, when buccal tablet and paster with the use of time, the back side due to paster is binding agent, and the both sides, front of paster are with annular casing, first buccal tablet is placed in annular casing, then the back side of paster is pasted on ulcer spot corresponding tooth on, the front of paster is right against ulcer surface, thus plays fixing action by contact, because corona belongs to sclerous tissues, therefore to oral mucosa not damaged.
accompanying drawing illustrates:
accompanying drawing 1 is the structural representation after buccal tablet of the present invention and paster are installed.
accompanying drawing 2 is the structural representations after installing with paster after buccal tablet of the present invention is cut into a kind of shape.
accompanying drawing 3 is the structural representations after installing with paster after buccal tablet of the present invention is cut into another kind of shape.
detailed description of the invention:
embodiment 1:
be used for the treatment of a buccal tablet for oral ulcer, described buccal tablet is laminated structure, and its substrate is hydrophilic and water-insoluble gel, and described buccal tablet contains antibacterial, and described antibacterial is comprised in the inside of described gel, and supportive skeleton is contained in the inside of described gel.
embodiment 2:
the buccal tablet being used for the treatment of oral ulcer according to embodiment 1, described buccal tablet is connected with paster, and the back side of described paster is binding agent, and the two ends, front of described paster are with annular casing, and described buccal tablet is positioned at the annular casing of described paster.
embodiment 3:
the buccal tablet being used for the treatment of oral ulcer according to embodiment 1 or 2, described hydrophilic and water-insoluble gel are cross-linked polyacrylamide, one composition in cross-linked sodium polyacrylate, starch grafted polyacrylamide, SANWET, cellulose graft polyacrylamide, cellulose graft sodium polyacrylate, poly hydroxy ethyl acrylate, cross-linked poly-methyl methacrylate hydroxyl ethyl ester or several copolymerization form.
embodiment 4:
the buccal tablet being used for the treatment of oral ulcer according to embodiment 1 or 2 or 3, described supportive skeleton is that one or more in sponge, fiber, fabric, thin film mix.
embodiment 5:
the buccal tablet being used for the treatment of oral ulcer according to embodiment 1 or 2 or 3 or 4, described antibacterial is that one or both in antibiotic, disinfectant mix.
embodiment 6:
the buccal tablet being used for the treatment of oral ulcer according to embodiment 1 or 2 or 3 or 4 or 5, described antibacterial has slow releasing preparation, and described slow releasing preparation is the one in microsphere, slow-release fiber, sustained release sponge, sustained release film.
embodiment 7:
the buccal tablet being used for the treatment of oral ulcer according to embodiment 1 or 2 or 3 or 4 or 5 or 6, described slow releasing preparation uses as described supportive skeleton simultaneously.
embodiment 8:
the buccal tablet being used for the treatment of oral ulcer according to embodiment 1 or 2 or 3 or 4 or 5 or 6 or 7, described binding agent is pressure sensitive adhesive.
embodiment 9:
the buccal tablet being used for the treatment of oral ulcer according to embodiment 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8, described buccal tablet thickness is 0.5 millimeter-10 millimeters.
embodiment 10:
according to the preparation method being used for the treatment of the buccal tablet of oral ulcer one of claim 1-9 Suo Shu, the method comprises the steps: first to prepare gel mixed solution, antibacterial is added in gel mixed solution, then supportive skeleton is put into the flat molds of 0.5 millimeter of-10 millimeters thick, and above-mentioned gel mixed solution is filled mould, finally polyase 13 0-60 minute at the temperature of 35 DEG C-40 DEG C, obtains the buccal tablet of solid.
embodiment 11:
the preparation method being used for the treatment of the buccal tablet of oral ulcer according to embodiment 10, the substrate of described buccal tablet adopts crosslinked polyacrylamide gels, first crosslinked polyacrylamide gels mixed solution is prepared, it is as follows that it prepares formula: 30% acrylamide solution of 66.6ml, 12.7ml water, the 1.5 mol/L Tris (pH8.8) of 20ml, 10% Ammonium persulfate. of 0.7ml, the Temed of 0.05ml; 30% described acrylamide solution formula is dissolved in 100ml water by the N-N-methylene bisacrylamide of the acrylamide of 29g and 1g; 1g poly hexamethylene biguanide (antibacterial) is added in above-mentioned gel mixed solution, mixed dissolution is even, the medical sponge (supportive skeleton) of 1.5mm thickness is inserted in the flat molds of 2mm thickness, above-mentioned mixed solution is filled mould, polyase 13 0min under 37 DEG C of conditions, obtain the crosslinked polyacrylamide gels thin slice poly-containing 1% poly hexamethylene biguanide of 2mm thickness, being cut into required form during use, being less than ulcer wound site containing using greatly.
embodiment 12:
the buccal tablet of oral ulcer and the preparation method of buccal tablet is used for the treatment of according to embodiment 10, the substrate of described buccal tablet adopts cross-linked sodium polyacrylate gel, supportive skeleton adopts hospital gauze, antibacterial adopts the PLA Microspheres of 5% minocycline, make the lamellar of 2.5mm thickness, be polymerized lyophilizing in latter 1 hour.
embodiment 13:
the buccal tablet of oral ulcer and the preparation method of buccal tablet is used for the treatment of according to embodiment 10, the substrate of described buccal tablet adopts SANWET gel, supportive skeleton adopts medical absorbent cotton fiber, antibacterial adopts the polylactic-co-glycolic acid sustained-release micro-spheres of 5% ornidazole, make the lamellar of 3mm thickness, be polymerized lyophilizing in latter 1 hour.
embodiment 14:
the buccal tablet of oral ulcer and the preparation method of buccal tablet is used for the treatment of according to embodiment 10, the substrate of described buccal tablet adopts cellulose graft polyacrylamide gel, antibacterial adopts the polylactic-co-glycolic acid sustained release film of 5% ornidazole, it is simultaneously as supportive skeleton, make the lamellar of 3mm thickness, be polymerized lyophilizing in latter 1 hour.
embodiment 15:
the buccal tablet of oral ulcer and the preparation method of buccal tablet is used for the treatment of according to embodiment 10.The substrate of described buccal tablet adopts poly hydroxy ethyl acrylate, and supportive skeleton adopts medical sponge, and antibacterial adopts the polylactic acid-sustained-release micro-spheres of 5% polyhexamethylene list guanidine, makes the lamellar of 2mm thickness, is polymerized lyophilizing in latter 1 hour.
embodiment 16:
according to the preparation method being used for the treatment of the buccal tablet of oral ulcer one of embodiment 10-15 Suo Shu, as shown in Figure 2, during use by obtained buccal tablet insert two ends, sticking tablet front annular casing in, then the back side of sticking tablet is pasted on ulcer spot for tooth on.
embodiment 17:
the buccal tablet of oral ulcer and the preparation method of buccal tablet is used for the treatment of according to according to one of embodiment 10-15, as shown in Figure 3, during use, buccal tablet is cut the teeth groove corresponding with sticking tablet annular casing, when buccal tablet being inserted the annular casing at two ends, sticking tablet front, annular casing is made to be positioned at the teeth groove of buccal tablet, make it fixing more firm, then the back side of sticking tablet is pasted on tooth corresponding to ulcer spot.
Claims (10)
1. one kind is used for the treatment of the buccal tablet of oral ulcer, it is characterized in that: described buccal tablet is laminated structure, its substrate is hydrophilic and water-insoluble gel, and described buccal tablet contains antibacterial, described antibacterial is comprised in the inside of described gel, and supportive skeleton is contained in the inside of described gel.
2. the buccal tablet being used for the treatment of oral ulcer according to claim 1, it is characterized in that: described buccal tablet is connected with paster, the back side of described paster is binding agent, and the two ends, front of described paster are with annular casing, and described buccal tablet is positioned at the annular casing at described paster two ends.
3. the buccal tablet being used for the treatment of oral ulcer according to claim 1 and 2, is characterized in that: described hydrophilic and water-insoluble gel are cross-linked polyacrylamide, one composition in cross-linked sodium polyacrylate, starch grafted polyacrylamide, SANWET, cellulose graft polyacrylamide, cellulose graft sodium polyacrylate, poly hydroxy ethyl acrylate, cross-linked poly-methyl methacrylate hydroxyl ethyl ester or several copolymerization form.
4. the buccal tablet being used for the treatment of oral ulcer according to claim 1 or 2 or 3, is characterized in that: described supportive skeleton is that one or more in sponge, fiber, fabric, thin film mix.
5. the buccal tablet being used for the treatment of oral ulcer according to claim 1 or 2 or 3 or 4, is characterized in that: described antibacterial is that one or more in antibiotic, disinfectant mix.
6. the buccal tablet being used for the treatment of oral ulcer according to claim 1 or 2 or 3 or 4 or 5, it is characterized in that: described antibacterial is slow releasing preparation, described slow releasing preparation is the one or more combination in sustained-release micro-spheres, slow-release fiber, sustained release sponge, sustained release film.
7. the buccal tablet being used for the treatment of oral ulcer according to claim 1 or 2 or 3 or 4 or 5 or 6, is characterized in that: described buccal tablet is dry body, preferred lyophilizing.
8. the buccal tablet being used for the treatment of oral ulcer according to claim 1 or 2 or 3 or 4 or 5 or 6 or 7, is characterized in that: described slow releasing preparation uses as supportive skeleton simultaneously.
9. the buccal tablet being used for the treatment of oral ulcer according to claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8, is characterized in that: described binding agent is adhesive of medical.
10. the buccal tablet being used for the treatment of oral ulcer according to claim 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9, is characterized in that: described buccal tablet thickness is 0.5 millimeter-10 millimeters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510307630.8A CN104856969A (en) | 2015-06-08 | 2015-06-08 | Buccal tablet for treating oral ulcer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510307630.8A CN104856969A (en) | 2015-06-08 | 2015-06-08 | Buccal tablet for treating oral ulcer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104856969A true CN104856969A (en) | 2015-08-26 |
Family
ID=53903444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510307630.8A Pending CN104856969A (en) | 2015-06-08 | 2015-06-08 | Buccal tablet for treating oral ulcer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104856969A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4765983A (en) * | 1985-06-05 | 1988-08-23 | Yamanouchi Pharmaceutical Co., Ltd. | Adhesive medical tapes for oral mucosa |
| CN101932309A (en) * | 2007-09-26 | 2010-12-29 | 贝恩斯公司 | Sustained release dosage forms for delivery of agents to an oral cavity of a user |
| CN103110610A (en) * | 2009-09-11 | 2013-05-22 | 上海微丸医药开发有限公司 | Mouth mucosa sustained-release preparation for treating oral and periodontal diseases by chlorhexidine |
| CN103582475A (en) * | 2011-05-27 | 2014-02-12 | 狮王株式会社 | Oral composition |
| CN103720603A (en) * | 2004-07-29 | 2014-04-16 | 高露洁-棕榄公司 | Oral care compositions with film forming polymers |
-
2015
- 2015-06-08 CN CN201510307630.8A patent/CN104856969A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4765983A (en) * | 1985-06-05 | 1988-08-23 | Yamanouchi Pharmaceutical Co., Ltd. | Adhesive medical tapes for oral mucosa |
| CN103720603A (en) * | 2004-07-29 | 2014-04-16 | 高露洁-棕榄公司 | Oral care compositions with film forming polymers |
| CN101932309A (en) * | 2007-09-26 | 2010-12-29 | 贝恩斯公司 | Sustained release dosage forms for delivery of agents to an oral cavity of a user |
| CN103110610A (en) * | 2009-09-11 | 2013-05-22 | 上海微丸医药开发有限公司 | Mouth mucosa sustained-release preparation for treating oral and periodontal diseases by chlorhexidine |
| CN103582475A (en) * | 2011-05-27 | 2014-02-12 | 狮王株式会社 | Oral composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0315606B2 (en) | ||
| CN102850598B (en) | Alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof | |
| JP2016511310A5 (en) | ||
| JP6212552B2 (en) | Dressing material that releases active ingredients continuously | |
| JP2003527356A (en) | A system for the controlled administration of active substances to dental sites | |
| JP2022523780A (en) | Antibacterial dressings, dressing components, and methods | |
| WO2007018622A3 (en) | Vaginal treatment composition | |
| CN102327161A (en) | Preparation process of wound dressing | |
| WO2019088227A1 (en) | Dental local anesthetic microneedle array | |
| CN109475608A (en) | The method of chronic wounds debridement | |
| US20050181025A1 (en) | Preparation for wound healing and prevention of bandage adhesion to the wound | |
| CN104856969A (en) | Buccal tablet for treating oral ulcer | |
| WO2022247183A1 (en) | Antibacterial patch and preparation method therefor | |
| CN102895699A (en) | Preparation method of composite hydrogel dressing for repairing skin injury | |
| CN203342090U (en) | Alginic acid dressing and application thereof | |
| CN210433776U (en) | Externally-used absorbable hemostatic material | |
| KR102020119B1 (en) | Wound dressings applicable for laser treatment and medical device for producing wound dressing thereof | |
| RU2201219C2 (en) | Pharmacological composition with prolonged effect | |
| UA28514U (en) | Antiseptic dressing material | |
| CN207886348U (en) | A kind of dentistry postoperation hemostatic dressing | |
| CN215779148U (en) | Hemostatic and antibacterial medical dressing | |
| Bruckner et al. | Evaluation of cellulose and polyhexamethylene biguanide (Suprasorb® X+ PHMB) in therapy of infected wounds | |
| CN213431816U (en) | Auxiliary patch for incubation of photosensitizer for oral mucosal disease | |
| CN218792766U (en) | Chitosan sterilization dressing plaster | |
| RU2792597C1 (en) | Drug composition with regenerative and antibacterial properties for the prevention of postoperative complications in rhinology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150826 |
|
| WD01 | Invention patent application deemed withdrawn after publication |