CN104856653A - Device and method for detecting blood vessel - Google Patents
Device and method for detecting blood vessel Download PDFInfo
- Publication number
- CN104856653A CN104856653A CN201510325800.5A CN201510325800A CN104856653A CN 104856653 A CN104856653 A CN 104856653A CN 201510325800 A CN201510325800 A CN 201510325800A CN 104856653 A CN104856653 A CN 104856653A
- Authority
- CN
- China
- Prior art keywords
- blood vessel
- visible light
- infrared
- visible
- far infrared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 86
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000003384 imaging method Methods 0.000 claims abstract description 58
- 238000012545 processing Methods 0.000 claims abstract description 34
- 230000005855 radiation Effects 0.000 claims abstract description 20
- 230000017531 blood circulation Effects 0.000 claims abstract description 19
- 238000001931 thermography Methods 0.000 claims abstract description 17
- 238000004458 analytical method Methods 0.000 claims abstract description 9
- 239000000835 fiber Substances 0.000 claims description 51
- 230000003287 optical effect Effects 0.000 claims description 34
- 238000001514 detection method Methods 0.000 claims description 15
- 210000003743 erythrocyte Anatomy 0.000 claims description 14
- 230000005540 biological transmission Effects 0.000 claims description 13
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 230000001951 hemoperfusion Effects 0.000 claims description 12
- 238000007639 printing Methods 0.000 claims description 12
- 230000002792 vascular Effects 0.000 claims description 12
- 238000010521 absorption reaction Methods 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 9
- 230000008520 organization Effects 0.000 claims description 7
- 230000036760 body temperature Effects 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 230000001360 synchronised effect Effects 0.000 claims description 5
- 238000013178 mathematical model Methods 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 3
- 230000008081 blood perfusion Effects 0.000 abstract description 9
- 230000002503 metabolic effect Effects 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
- 210000000056 organ Anatomy 0.000 abstract description 7
- 238000005516 engineering process Methods 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 6
- 238000012546 transfer Methods 0.000 abstract description 6
- 239000013307 optical fiber Substances 0.000 abstract description 5
- 230000007170 pathology Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 85
- 210000004369 blood Anatomy 0.000 description 44
- 239000008280 blood Substances 0.000 description 44
- 210000004027 cell Anatomy 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- XHCLAFWTIXFWPH-UHFFFAOYSA-N [O-2].[O-2].[O-2].[O-2].[O-2].[V+5].[V+5] Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[V+5].[V+5] XHCLAFWTIXFWPH-UHFFFAOYSA-N 0.000 description 3
- 229910052732 germanium Inorganic materials 0.000 description 3
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 3
- 210000003701 histiocyte Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000005693 optoelectronics Effects 0.000 description 3
- 230000001575 pathological effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229910001935 vanadium oxide Inorganic materials 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000000887 face Anatomy 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000011900 installation process Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010062038 Lip neoplasm Diseases 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 240000000783 Origanum majorana Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 206010057040 Temperature intolerance Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010043966 Tongue neoplasm malignant stage unspecified Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000013499 data model Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000008543 heat sensitivity Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000003331 infrared imaging Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 201000006721 lip cancer Diseases 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000000886 photobiology Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000013308 plastic optical fiber Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Radiation Pyrometers (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a device and a method for detecting a blood vessel. The device comprises a visible light source, an optical fiber coupler, a lighting optical fiber, an imaging receiving channel, an infrared beam splitter, a far infrared lens zoom system, a far infrared detector, a visible light lens zoom system, a visible light image sensor and an image processing system. According to the characteristic and the blood vessel blood flow heat transfer property that different heat radiation is generated by metabolic activity of hot body cells, tissues or organs in different states, infrared thermal imaging technology is integrated with visible light imaging technology, a high-quality and high-contrast blood vessel image is acquired, analysis of related blood flow parameters such as blood vessel blood flow speed and blood perfusion can be assisted, and early disease prediction and health assessment are performed according to temperature characteristics of human tissues under different pathologies.
Description
Technical field
The present invention relates to Photobiology technical field of imaging, particularly relating to a kind of apparatus and method for detecting blood vessel.
Background technology
In human body, blood vessel is the pipeline of pumping blood, can be divided into tremulous pulse, vein and blood capillary according to transporting direction.Blood is brought to bodily tissue from heart by tremulous pulse, vein takes back heart by between blood self-organizing, and blood capillary then connects tremulous pulse and vein, is the main place of mass exchange between blood and tissue, and be extensively distributed to whole body respectively to organize and iuntercellular, therefore blood capillary is also referred to as microcirculation.
Under normal circumstances, the metaboilic level of microvascular blood flow and tissue, organ adapts, and ensures the hemoperfusion amount of each histoorgan and regulates returned blood volume, making each organ physiological function in human body be able to normal operation.Blood capillary is easy to obstacle occurs.With advancing age, each organ of human body can be old and feeble gradually, and its function is also degenerated naturally thereupon, and this is the internal cause causing blood capillary obstacle.In pathological conditions, due to the effect of various paathogenic factor, microvascular function generation obstacle can be increased the weight of again.Blood capillary obstacle can change blood physicochemical property, be mainly manifested in the blood vessel on microvascular and the change of blood flow in function and morphology, make luminal stenosis, velocity of blood flow or slow down or form thrombosis, make local organization hypoxic-ischemic even downright bad, and then cause a series of clinical symptoms.Medical science proves: the aging of human body, the generation of tumor, and hypertension, diabetes and many cardio-cerebrovascular diseases are mainly caused by blood capillary obstacle.Blood capillary obstacle is the coexpress of a lot of pathological process and disease.Therefore, normally whether blood capillary, is the whether healthy important symbol of human body.
Microvascular observation Detection of content generally includes three aspects: form, phenomenon dynamically and around blood capillary.Microvascular observation detects position and mainly concentrates on body surface and mucosa, the positions such as domestic comparatively conventional first folds in a garment, bulbar conjunctiva, tongue, lip.Microvascular observation detects the traditional normal incident light spectrum imaging method of many employings, and the method can obtain ideal blood capillary image, but directly cannot show the situation of blood capillary perienchyma.
Summary of the invention
For above-mentioned the deficiencies in the prior art, the invention provides a kind of apparatus and method detected for blood vessel.
For achieving the above object, the present invention adopts following technical scheme:
For detecting the device of blood vessel, comprise visible light source, fiber coupler, lighting fiber, imaging receiver passage, infrared light spectroscope, far infrared lens zoom system, far infrared deterctor, visible light lens zoom system, pancreatic system, visible light image sensor and image processing system;
Described visible light source, for sending the visible ray that can be absorbed by erythrocyte;
Described fiber coupler, is arranged on the direction of advance of described visible ray, for receiving the visible ray that described visible light source sends;
Described lighting fiber, is connected with described fiber coupler, for transmitting described visible ray, and projects human tissue surface after being derived by visible ray;
Described imaging receiver passage, returns the visible ray of tissue surface and the far infrared of tissue radiation for collecting from organization internal scattering;
Described infrared light spectroscope, is arranged on the top of imaging receiver passage, for separating of far infrared and visible ray;
Described visible light lens zoom system, pancreatic system, for adjusting the focusing distance of visible ray;
Described visible light image sensor, for optical signal is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, exports digital visible images;
Described far infrared lens zoom system, keeps synchronous for the focusing distance adjusting described far infrared with the focal length of described visible light lens zoom system, pancreatic system;
Described far infrared deterctor, for the far-infrared heat radiation signal of incidence is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, exports digital Far-infrared thermography;
Described image processing system, for described visible images and Far-infrared thermography registration are merged, the blood-vessel image of outputting high quality.
Preferably, described fiber coupler comprises fixed cover, condenser lens and optical branching device, described visible light source is fixed in fixed cover, the direction of advance of visible ray installs condenser lens and optical branching device successively, one end of optical branching device is fixedly connected with fixed cover, the other end of optical branching device is connected with lighting fiber, described lighting fiber is in the periphery of imaging receiver passage, described imaging receiver passage comprises circular tube shaped passage and collimating lens, collimating lens is arranged at the bottom of circular tube shaped passage, described infrared light spectroscope is the top that 45° angle is arranged on circular tube shaped passage, the side that circular tube shaped passage is relative with infrared light spectroscope is provided with printing opacity mouth, optical filter is posted at printing opacity mouth place.
Preferably, described circular tube shaped channel interior scribbles anti-reflection coating.
Preferably, visible light source is light emitting diode, and the wavelength of its incident ray is 410-430nm, 525-550nm or 780-800nm; Optical filter identical with the wavelength of incident ray through wavelength.
Preferably, described device is used for microvascular detection.
The present invention still further provides a kind of method for detecting blood vessel, comprises the following steps:
The visible ray that S1, visible light source send adopts the mode of side incidence to project human tissue surface through lighting fiber;
S2, imaging receiver passage collect the far infrared that the visible ray carrying vessel information of returning through tissue transmission and tissue radiation go out, after the light splitting of infrared light spectroscope, visible ray is transported to visible light lens zoom system, pancreatic system, and far infrared is transported to far infrared lens zoom system;
S3, visible light lens zoom system, pancreatic system project visible light image sensor after being focused on by the visible ray carrying vessel information collected, and obtain blood vessel visible images;
The zoom focal length parameter of visible light lens zoom system, pancreatic system described in S4, far infrared lens zoom system synchronization, projects far infrared deterctor after being focused on by described far infrared, obtains the infrared chart in institute's test set tissue region;
S5, image processing system carry out registration fusion to described visible images and described infrared chart, obtain blood-vessel image.
Preferably, the method for detecting blood vessel also comprises step S6 and utilizes temperature information to analyze the parameter of blood vessel on blood-vessel image, is reflected hemoperfusion degree height and the velocity of blood flow of tissue by the height of tissues surrounding vascular temperature.
Step S6 also comprises and utilizes the temperature profile of temperature information to tissue to analyze: utilize erythrocyte to the principle of absorption of visible ray to while blood vessel imaging, also utilize the tissue temperature field distribution of far infrared deterctor testing human and build three-dimensional temperature field mathematical model, obtaining human body temperature feature.
Preferably, described method is used for microvascular detection.
Compared with prior art, the present invention, for detecting the apparatus and method of blood vessel, has following beneficial effect:
(1) picture contrast using the present invention to obtain for the apparatus and method detecting blood vessel is high.In the present invention, visible ray adopts side incidence, makes surveyed area be rendered as the imaging technique of dark field, obtains the blood vessel imaging of more high image quality, more high-contrast with less energy; Produce heat radiation and the blood circulation characteristic to the exclusive thermal cycle of tissue heat transfer when utilizing histiocyte metabolism simultaneously, by Far infra-red hot detector, heat distribution detection is carried out to imaging of tissue region, obtain the thermal map of tissue, then two image registrations are merged, with temperature profile, blood vessel is compensated, improve the contrast of image further.
(2) when being in different conditions according to hot body cell, tissue or organ, its metabolic activity and the different feature of the heat radiation produced, and vessel heat transfer characteristic, also can the related blood stream parameter such as assistant analysis vascular flow speed, hemoperfusion degree, and according to the temperature profile of tissue under different pathological, carry out early prediction and the health evaluating of disease.
Accompanying drawing explanation
Fig. 1 is that the present invention is for detecting the block diagram of an embodiment of the device of blood vessel;
Fig. 2 is for detecting the structural representation of the device of blood vessel in Fig. 1;
Fig. 3 is that the present invention is for detecting the schematic flow sheet of an embodiment of the method for blood vessel.
Reference numeral is:
Visible light source 1, fiber coupler 2, fixed cover 21, condenser lens 22, optical branching device 23, lighting fiber 3, imaging receiver passage 4, circular tube shaped passage 41, collimating lens 42, printing opacity mouth 43, infrared light spectroscope 5, far infrared lens zoom system 61, far infrared deterctor 62, visible light lens zoom system, pancreatic system 71, visible light image sensor 72, image processing system 8, human tissue surface 9.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described.The elements such as the fiber coupler used in the present invention, infrared light spectroscope, far infrared lens zoom system, far infrared deterctor, visible light lens zoom system, pancreatic system, visible light image sensor and image processing system are all commercially available prod.
Embodiment 1
See Fig. 1, the device for detecting blood vessel described in the present embodiment, comprises visible light source 1, fiber coupler 2, lighting fiber 3, imaging receiver passage 4, infrared light spectroscope 5, far infrared lens zoom system 61, far infrared deterctor 62, visible light lens zoom system, pancreatic system 71, visible light image sensor 72 and image processing system 8; Described visible light source 1 is for sending the visible ray that can be absorbed by erythrocyte; Described fiber coupler 2 is arranged on the direction of advance of described visible ray, for receiving the visible ray that described visible light source 1 sends; Described lighting fiber 3 is connected with described fiber coupler 2, for transmitting described visible ray, and projects human tissue surface 9 after being derived by visible ray; Described imaging receiver passage 4 returns the visible ray of tissue surface and the far infrared of tissue radiation for collecting from organization internal scattering; Described infrared light spectroscope 5 is arranged on the top of imaging receiver passage 4, for separating of far infrared and visible ray; Described visible light lens zoom system, pancreatic system 71, for adjusting the focusing distance of visible ray; Described visible light image sensor 72, for optical signal is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, exports digital visible image signal; Described far infrared lens zoom system 61, for adjusting the focusing distance of described far infrared, makes it keep synchronous with the focal length of described visible light lens zoom system, pancreatic system 71; Described far infrared deterctor 62, for the far-infrared heat radiation signal of incidence is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, exports digital Far-infrared thermography; Described image processing system 8, for described visible images and Far-infrared thermography registration are merged, by the display of identical proportional sizes, the blood-vessel image of outputting high quality.Visible images after registration merges and Far-infrared thermography can be shown in the same window by same ratio size, can to show with different windows by same ratio size.
Described visible light source 1 can provide the visible ray of certain wavelength and energy, for the lighting source of visual light imaging.Particularly, visible light source 1 is light emitting diode, and the wavelength of preferred incident ray is the light emitting diode of 410-430nm, 525-550nm or 780-800nm, and hemoglobin has higher absorbance to the wavelength within the scope of these three kinds.The present invention can adopt absolute wavelength to detect blood vessel by selecting the wavelength of visible light source to realize for the device detecting blood vessel, and the contrast of image is high.
Optical signal is divided into multichannel and propagates by described fiber coupler 2, and the light energy of described visible ray can be coupled in described lighting fiber 3 to greatest extent.Described lighting fiber 3 is that one group of optical fiber passes light beam, is connected with described fiber coupler 2, for transmitting described visible ray, and visible ray is directly directed to the position needing to observe or detect.Optical fiber has the advantages such as little, the easy to operate and cold light source of volume, is suitable for very much the transmission of visible ray.Preferably, the diameter of lighting fiber 3 is 0.5-6mm, and its length is determined depending on operation requirements, and preferred length is 150-3000mm.Lighting fiber 3 material type used includes but not limited to: multicomponent glass optical fiber, silica fibre or polymer optical fiber.
The periphery of imaging receiver passage 4 arranges lighting fiber 3, the visible ray that lighting fiber 3 casts out can not directly enter imaging receiver passage 4, imaging receiver passage 4 only can collect from organization internal scattering return tissue surface luminous ray and organize thermal-radiating far infrared.Described imaging receiver passage 4 comprises circular tube shaped passage 41 and collimating lens 42, collimating lens 42 is arranged at the light entrance place of circular tube shaped passage 41 bottom, for the far infrared collimation visible ray gone out from tissue internal transmission collected and tissue given off.Circular tube shaped passage 41 leaves printing opacity mouth 43 in the side that infrared light spectroscope 5 faces, and the visible ray after reflection enters visible light lens zoom system, pancreatic system 71 through printing opacity mouth 43 through after imaging receiver passage 4.Printing opacity mouth 43 posts a multilayer filter, for the background noise that filtering is spuious, improves picture contrast.
Described infrared light spectroscope 5 is arranged on the top of imaging receiver passage 4, for visible ray is separated with far infrared, far infrared from its inside through, visible ray is from its surface reflection.The incident angle of infrared light spectroscope 5 is 45 °.In concrete installation process, infrared light spectroscope 5 is that 45° angle is placed on imaging receiver passage 4 top, ensures that visible ray and far infrared incide infrared light spectroscope 5 with 45° angle.
Described visible light lens zoom system, pancreatic system 71, for adjusting the focusing distance of described visible ray, makes imaging clearly; Visible light lens zoom system, pancreatic system 71 is made up of visible light lens group and visible light lens drive circuit.Visible light lens group is made up of multiple lens, iris aperture and focusing ring, realizes the difference in functionalitys such as focusing, amplification, brightness increase and decrease.Visible light lens group drive circuit intercoms mutually with image processing system and far infrared lens group drive circuit, ensure that visible light lens group is identical with far infrared lens group zoom focal length parameter, pel array in the same way.Described visible light image sensor 72 for optical signal is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, output digital image signal.
Described far infrared lens zoom system 61, for adjusting the focusing distance of described far infrared, keeps synchronous with visible ray focal length; Far infrared lens zoom system 61 comprises lens group and lens driving circuit two parts.Described lens group preferred transmission formula structure lens group, it has larger numerical aperture and non-stop layer stops, and while noise decrease equivalent temperature difference, increase light gathering, improves the temperature resolution of system; The preferred germanium infrared aspheric lens of eyeglass used, in the detection to weak signal, reaches the ability of stronger suppression veiling glare, and Heat stability is good, not out of focus in wide temperature range.
Described far infrared deterctor 62 for the described far-infrared heat radiation signal of incidence is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, output digital image signal.Particularly, described far infrared deterctor 62 preferably non-refrigerated infrared focal plane probe.Non-refrigerating infrared focal plane technology belongs to pyroelectric detector class thermal imaging, and non-refrigerated infrared focal plane probe can be divided into one chip and hybrid-type by structure.One chip thermal detector is the responsive first array of infrared acquisition supporting unsettled (i.e. micro-bridge structure) on reading circuit with heat isolation arm; Hybrid-type uncooled fpa detector is then make the responsive first array in focal plane and cmos signal reading circuit respectively, finally adopts the infrared focal plane array that the two fits together by indium post face-down bonding technique.Compared with BCD hybrid technology, one-piece construction can eliminate the effects such as pseudo-edge, haloing and stroboscopic, and completely isolated between the contiguous pixel of its array almost eliminates cross-talk, image streaking and blooming.Therefore, the uncooled fpa detector of one chip has potential performance advantage than hybrid-type focus planardetector.Described non-refrigerated infrared focal plane probe can be divided into again micro-metering bolometer, thermoelectric type and thermoelectric pile 3 type by mode of operation.Wherein, micro-metering bolometer is made up of reading circuit, micro-bridge structure array, vanadium oxide thin film material, encapsulation, and wherein the effect of vanadium oxide film is that infra-red radiation is transformed into the signal of telecommunication; Micro-bridge structure is by unsettled for vanadium oxide film thereon, and its minimum thermal capacity and thermal conductance ensure that there is sufficiently high heat sensitivity in detection unit; The signal of each detection unit reads by reading circuit, and the signal of telecommunication becoming spatial distribution is clock signal, so that realize staring thermal imaging, simultaneously as the support substrates of micro-bridge structure.
The visible images that described image processing system 8 exports for the Far-infrared thermography and described visible light image sensor 72 receiving the output of described far infrared deterctor 62, and described visible images and described Far-infrared thermography registration are merged, by the display of identical proportional sizes, the blood-vessel image of outputting high quality.In addition, described image processing system can also analyze relevant blood vessel parameter and the temperature profile of tissue simultaneously.
The present invention is as follows for the basic functional principle of the device detecting blood vessel: visible light source 1 launches the visible ray that can be absorbed by erythrocyte; The visible ray that visible light source 1 sends collected by fiber coupler 2, and visible ray is coupled to lighting fiber 3; Visible ray is projected human tissue surface 9 by lighting fiber 3.Some meeting transmission of visible ray enter tissue inside, in the continuation scattering of tissue inside with by Tissue Blood erythrocyte strong absorption; Imaging receiver passage 4 gathers simultaneously and collimates far infrared that tissue radiation goes out and from the tissue internal transmission visible ray containing vessel information out; Infrared light spectroscope 5 reflect visible light, transmission far infrared are to realize being separated of visible ray and far infrared; Far infrared lens zoom system 61 far infrared is amplified focus on after project far infrared deterctor 62 and carry out opto-electronic conversion and obtain organizing infrared chart information; Visible light lens zoom system, pancreatic system 71 visible ray is amplified focus on after project visible light image sensor 72 and carry out opto-electronic conversion and obtain blood-vessel image information; Image processing system receives from the tissue infrared chart information of far infrared deterctor 62 and the blood-vessel image information of visible light image sensor 72, merges, analyzes two width image registrations.Image after being merged by registration can obtain width, the length of blood vessel, and the information such as vasoganglion distribution and density, analyze further and can also obtain the information such as blood flow rate, hemoperfusion degree and temperature difference.
Can form the obvious temperature line of a rule dark background in Far-infrared thermography, these temperature line compensate original blood-vessel image.Described image processing system 8, after described visible images and described Far-infrared thermography registration being merged, utilizes temperature information to analyze the parameter of blood vessel on blood-vessel image and the temperature profile of tissue, comprises the following steps:
(1) analysis of blood perfusion rate and velocity of blood flow.In prior art, visual light imaging device can calculate velocity of blood flow and perfusion degree, but will obtain and accurately calculate data, more difficult.By infrared imaging method assistant analysis velocity of blood flow and perfusion degree in the present invention, infrared data is combined with visible data and obtains velocity of blood flow and perfusion degree accurately.Utilize erythrocyte to the principle of absorption of visible ray to after blood vessel imaging, blood perfusion rate also cannot manifest intuitively in the picture.The present invention assists hemoperfusion degree height and the velocity of blood flow speed of reflection tissue by the height of detection tissues surrounding vascular temperature.Affect this is because tissues surrounding vascular temperature is mainly subject to blood perfusion rate, the oxygen content of blood vessel and hemorheology is isoparametric.
The impact of blood perfusion rate on tissues surrounding vascular temperature is mainly reflected in the degrees of expansion of blood vessel in tissue, when blood perfusion rate increases, corresponding arteries increases thick, make the Marjoram Extract that cannot manifest during Low perfusion rate, cause blood vessel number, size relative changes in tissue, because circumvascular tissue and blood heat exchange can occur, thus make tissues surrounding vascular change of temperature field, so the height of detection tissues surrounding vascular temperature just reflects the problem of the hemoperfusion degree height of tissue.Implement in measuring and calculating concrete, tissues surrounding vascular temperature is proportional with hemoperfusion degree, and tissues surrounding vascular temperature is high, then hemoperfusion degree is height, and tissues surrounding vascular temperature is lower, then hemoperfusion degree is low herein.Apparatus of the present invention, by collecting the sample data of tissue temperature change in test process, the flow velocity of reference standard and the relational data model of temperature, adopt normalization average value method to after sample data analyzing and processing, draw velocity of blood flow data.
(2) analysis of the temperature profile of tissue.There are two heat sources in tissue temperature field, and one is the heat exchange effect from blood vessel circulation, a heat produced when being histiocyte metabolism.When hot body cell, tissue or organ are in different conditions, its metabolic activity and the heat radiation produced are different.As certain tissue be in chronic disease, blood for not enough or local necrosis state time, its metabolic heat intensity is just on the low side; And metabolic heat intensity higher time, show as pain, hypertrophy, inflammation, tumor etc. more.For cancer card, at patient early stage (First Year, occupy-place is below millimeter), the metabolic heat output of cancerous cell can reach 70mw/cm
3more than 2 degrees Celsius can be reached with the temperature difference of its surrounding normal cell, and cancerous cell is in vivo in distributed in three dimensions, therefore the early prediction of disease will be realized, just need utilize erythrocyte to the principle of absorption of visible ray to blood vessel imaging while, also utilize the tissue temperature field distribution of far infrared deterctor testing human and build three-dimensional temperature field mathematical model, obtaining human body temperature feature.
The tissue used in the present invention, the heat transfer equation of blood are as shown in following formula:
div(λ
tgradT
t)+ρ
bc
bW
b(T
b-T
t)+Q
met＝0 (1)
In formula (1), formula (2), ρ
tfor tissue density, ρ
bfor the density of blood, Q
metfor biological metabolic heat; T
tfor tissue temperature, T
bfor blood heat, c
bfor organizing specific heat capacity at constant pressure, λ
tfor organizing heat conductivity, λ
bfor blood heat conductivity.The present invention uses bioheat technology, receive the heat radiation that metabolism of human cell produces, and by the chromatographic technique of distinctive imaging with " from outward appearance to inner essence ", measure the distribution of abnormal thermal source in body, the degree of depth, intensity, form and tendency, thus comprehensively, truly, dynamically reflect the holistic health expressed by body metabolism heat, be that current clinical medicine is splendid, the supplementary detection means of green.
Based on the structure in the temperature field of above search coverage, come guide image collection and analysis by software, just can identify that application of temperature stimulates the thermal signal of rear suspicious lesions and surrounding skin, may be used for the early prediction and the health evaluating that carry out disease, as:
1) early warning of cancer.As the tissue such as tongue, lip is carried out blood capillary detect time, when test to blood for not enough and temperature is higher region, will mark especially on described blood capillary image in addition carry out early warning.Verify whether be carcinoma of tongue, lip cancer afterwards.
2) devitalized tissue is found.General devitalized tissue is except matt appearance, more muddy, lose outside the elasticity of normal structure, also because without normal blood supply, temperature is lower, figure line processing system 8 will carry out early warning to the suspicious lesion tissue region detected on described blood-vessel image.
Use the present invention for detecting the apparatus and method of blood vessel, can improve the contrast of blood-vessel image, the contrast of the blood-vessel image of acquisition is high.The raising of contrast mainly contains following factor:
(1) change illumination visible ray incidence and improve contrast.Common vessel detector adopts the mode of polarized light normal incidence, and analyzer cannot whole background noises of firing back of effective filtering tissue surface, cause picture contrast on the low side.The present invention adopts the mode of visible ray side incidence, surveyed area is made to be rendered as the imaging technique of dark field, and the optical noise that imaging receiver passage anti-reflection coating well avoids beyond from tissue surface infiltrates, the light source that scotopia place obtains all from organization internal by scattering after erythrocyte strong absorption and the light transmitted, avoid the pollution of optical noise, improve the contrast of blood-vessel image to a certain extent.
(2) temperature information is utilized to improve the contrast of described blood-vessel image.Because vessel inner blood temperature is higher than the temperature of tissues surrounding vascular, the tissue near blood vessel can have higher temperature, and can form the obvious temperature line of a rule dark background in Far-infrared thermography, these temperature line compensate original blood-vessel image.By change illumination visible ray incidence and temperature to the lifting of the compensating action twice pair of picture contrast of blood vessel, just make blood-vessel image reach higher picture contrast.
Embodiment 2
For a better understanding of the present invention, below in conjunction with a specific embodiment, structure of the present invention is described further.The content do not described in detail is in the present embodiment identical with embodiment 1.
As shown in Figure 2, the present invention, for detecting the device of blood vessel, comprises visible light source 1, fiber coupler 2, lighting fiber 3, imaging receiver passage 4, infrared light spectroscope 5, far infrared lens zoom system 61, far infrared deterctor 62, visible light lens zoom system, pancreatic system 71, visible light image sensor 72 and image processing system 8, described fiber coupler 2 comprises fixed cover 21, condenser lens 22 and optical branching device 23, described visible light source 1 is fixed in fixed cover 21, the direction of advance of visible ray is installed successively condenser lens 22 and optical branching device 23, one end of optical branching device 23 is fixedly connected with fixed cover 21, the other end of optical branching device 23 is connected with lighting fiber 3, described imaging receiver passage 4 comprises circular tube shaped passage 41 and collimating lens 42, collimating lens 42 is arranged at the bottom of circular tube shaped passage 41, circular tube shaped passage 41 inside scribbles anti-reflection coating, described lighting fiber 3 is in the periphery of imaging receiver passage 4, described infrared light spectroscope 5 is arranged on the top of circular tube shaped passage 41 in 45° angle, the side that circular tube shaped passage 41 is relative with infrared light spectroscope 5 is provided with printing opacity mouth 43, optical filter 44 is posted at printing opacity mouth 43 place.
Described fiber coupler 2, is arranged on the direction of advance of described visible ray, for receiving the visible ray that described visible light source 1 sends, the light energy of described visible ray can be coupled in described lighting fiber 3 to greatest extent.Described fixed cover 21, for fixing described visible light source 1 and described condenser lens 22, covers on outside described visible light source 1 simultaneously, better to collect visible ray, improves visible ray utilization rate.Described condenser lens 22 is arranged on the direction of advance of described visible ray, for being collimated by visible ray and converging, makes that visible ray is more efficient is coupled into optical branching device 23.Optical branching device 23 adopts fused tapered technique to make, can in implementation in one, optical branching device 23 final molding is the special Wave guide structure of bicone form, by controlling the angle of optic fibre turning and the length of stretching, makes each road all obtain identical light splitting ratio.
The wavelength of the described incident ray that the visible light source 1 in the present embodiment provides is 550nm, but is not limited to 550nm.Lighting fiber 3 in the present embodiment adopts the silica fibre with higher light transmittance, and diameter is 1mm, but is not limited to 1mm.
The periphery of described imaging receiver passage 4 arranges lighting fiber 3.Imaging receiver passage 4 only can collect from organization internal scattering return tissue surface luminous ray and carry out the thermal-radiating far infrared of self-organizing.Circular tube shaped passage 41 ensures that the light inside and outside imaging receiver passage 4 is completely isolated, avoids the pollution of optical noise.Preferably, circular tube shaped passage 41 inside scribbles anti-reflection coating, prevents the light secondary reflection again after reflection from lens or scattering, improves picture contrast.Described imaging receiver passage 4 inside also includes a collimating lens 42, collimating lens 42 is arranged at the light entrance place of imaging receiver passage 4 bottom, for the far infrared collimation visible ray gone out from tissue internal transmission collected and tissue given off.
Described infrared light spectroscope 5 belongs to double-tone spectroscope, adopts the thick germanium crystal material of 1mm to be prepared from, plates antireflection rete and optical filtering rete, make the far infrared of 8-14 mu m waveband have maximum transmission after surperficial twin polishing; The luminous ray of 420nm-680nm has high reflectance.In concrete installation process, infrared light spectroscope 5 is that 45° angle is placed on imaging receiver passage 4 top, ensures that visible ray and far infrared incide spectroscope with 45° angle, far infrared from its inside through, visible ray is from its surface reflection.Imaging receiver passage 4 leaves printing opacity mouth 43 in the side that infrared light spectroscope 5 faces, and one deck 550nm optical filter is posted at printing opacity mouth 43 place, for the background noise that filtering is spuious, improves picture contrast.
Described far infrared lens zoom system 61, for adjusting the focusing distance of described far infrared, keeps synchronous with visible ray focal length; Far infrared lens zoom system 61 comprises lens group and lens driving circuit two parts.Lens group described in the present embodiment adopts transmission-type structure, and eyeglass adopts germanium infrared aspheric lens.Described far infrared deterctor 62, for the described far-infrared heat radiation signal of incidence is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, output digital image signal.The spectral response wave-length coverage of far infrared deterctor 62 is 8-14um, and pixel divides 320*240 and 1,60*,120 two kinds, preferably adopts 320*240 pixel.
Described visible light lens zoom system, pancreatic system 71, for adjusting the focusing distance of described visible ray, makes imaging clearly; Visible light lens zoom system, pancreatic system 71 is made up of visible light lens group and visible light lens drive circuit.Described visible light image sensor 72, for optical signal is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, output digital image signal; During concrete enforcement, visible light image sensor 72 is charge coupled cell imageing sensor, and it adopts planar array type structure, is arranged in a square formation by a lot of photosensitive area, and connects into a device with certain form, and obtaining information amount is large, can process complicated image.
The visible images that described image processing system 8 exports for the Far-infrared thermography and described visible light image sensor 72 receiving the output of described far infrared deterctor 62, and described visible images and described Far-infrared thermography registration are merged, be shown in the same window by identical proportional sizes, the blood-vessel image of outputting high quality.In addition, described image processing system 8 can also analyze relevant blood vessel parameter and the temperature profile of tissue.Therefore, the device that the present invention detects blood vessel may be used for carrying out early prediction and the health evaluating of disease.
In the present embodiment, when adopting the device for detecting blood vessel to carry out blood capillary graphical analysis, its specific works process is:
Visible light source 1 launches the visible ray that better can be absorbed by erythrocyte; Fixed cover 21 covers on outside visible light source 1, and after described visible ray collimates by built-in condensing lens 22, pinching is to optical branching device 23; Lighting fiber 3 is connected with optical branching device 23, and described visible ray is projected the periphery of tissue surveyed area, continues refraction, scattering, diffraction after described visible ray part meeting transmission enters tissue inside, and by erythrocyte strong absorption; Imaging receiver passage 4 is collected by the visible ray transmitted after erythrocyte strong absorption in surveyed area, the far infrared of also collector soma surveyed area externally radiation simultaneously; The visible ray collected and far infrared first can project infrared light spectroscope 5 after collimating lens 42 collimates, far infrared is from infrared light spectroscope 5 internal transmission, after far infrared lens zoom system 61 zoom, project far infrared deterctor 62, convert digital infrared chart signal to; Visible ray is from infrared light spectroscope 5 surface reflection, and after visible light lens zoom system, pancreatic system 71 zoom, project visible light image sensor 72, opto-electronic conversion becomes digital visible image signal; Image processing system 8 receives described digital infrared chart signal and described digital visible image signal, two width image registrations are merged, the temperature obtained is utilized to compensate image, the blood capillary image of outputting high quality and analyze the health status of human body further.
Embodiment 3
Present invention also offers a kind of method for detecting blood vessel.Referring to Fig. 3, utilize tissue blood capillary is detected for the device detecting blood vessel in above-described embodiment 1 or 2, comprise the following steps:
The visible ray that S1, visible light source send adopts the mode of side incidence to project human tissue surface through lighting fiber;
S2, imaging receiver passage collect the far infrared that the visible ray carrying blood capillary information of returning through tissue transmission and tissue detection district give off, after the light splitting of infrared light spectroscope, visible ray is transported to visible light lens zoom system, pancreatic system, and far infrared is transported to far infrared lens zoom system;
S3, visible light lens zoom system, pancreatic system project visible light image sensor after being focused on by the visible ray of the blood capillary information of carrying collected, and obtain blood capillary visible images;
The zoom focal length parameter of visible light lens zoom system, pancreatic system described in S4, far infrared lens zoom system synchronization, projects far infrared deterctor after being focused on by described far infrared, obtains the infrared chart in institute's test set tissue region;
S5, image processing system carry out registration fusion to described visible images and described infrared chart, obtain blood capillary image.
Preferably, the method for detecting blood vessel also comprises step S6 and utilizes temperature information to analyze parameter microvascular on blood capillary image, is reflected hemoperfusion degree height and the velocity of blood flow of tissue by the height of blood capillary surrounding tissue temperature;
Preferably, step S6 also comprises and utilizes the temperature profile of temperature information to tissue to analyze: utilize erythrocyte to the principle of absorption of visible ray to while blood capillary imaging, also utilize the tissue temperature field distribution of far infrared deterctor testing human and build three-dimensional temperature field mathematical model, obtaining human body temperature feature.
Preferably, the described method for detecting blood vessel is for microvascular detection.
The present invention utilizes the above-described device for detecting blood vessel for the method detecting blood vessel, and visible ray adopts side incidence, makes surveyed area be rendered as the imaging technique of dark field, obtains the blood capillary imaging of more high image quality with less energy, produce heat radiation and the blood circulation characteristic to the exclusive thermal cycle of tissue heat transfer when utilizing histiocyte metabolism simultaneously, by Far infra-red hot detector, heat distribution detection is carried out to imaging of tissue region, obtain the thermal map of tissue, then two images are combined, according to hot body cell, when tissue or organ are in different conditions, its metabolic activity and the different feature of the heat radiation produced, and blood capillary heat-transfer character, also can assistant analysis microvascular blood flow velocity, the related blood stream parameters such as hemoperfusion degree, the blood vessel temperature detected is utilized to compensate blood capillary parameter, acquisition high-contrast, comprise blood vessel parameter information, high-quality blood capillary image, and according to the temperature profile of tissue under different pathological, carry out early prediction and the health evaluating of disease.
The above is the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.
Claims (10)
1. one kind for detecting the device of blood vessel, it is characterized in that, comprise visible light source, fiber coupler, lighting fiber, imaging receiver passage, infrared light spectroscope, far infrared lens zoom system, far infrared deterctor, visible light lens zoom system, pancreatic system, visible light image sensor and image processing system;
Described visible light source, for sending the visible ray that can be absorbed by erythrocyte;
Described fiber coupler, is arranged on the direction of advance of described visible ray, for receiving the visible ray that described visible light source sends;
Described lighting fiber, is connected with described fiber coupler, for transmitting described visible ray, and projects human tissue surface after being derived by visible ray;
Described imaging receiver passage, returns the visible ray of tissue surface and the far infrared of tissue radiation for collecting from organization internal scattering;
Described infrared light spectroscope, is arranged on the top of imaging receiver passage, for separating of far infrared and visible ray;
Described visible light lens zoom system, pancreatic system, for adjusting the focusing distance of visible ray;
Described visible light image sensor, for optical signal is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, exports digital visible images;
Described far infrared lens zoom system, keeps synchronous for the focusing distance adjusting described far infrared with the focal length of described visible light lens zoom system, pancreatic system;
Described far infrared deterctor, for the far-infrared heat radiation signal of incidence is converted to the signal of telecommunication, after processing and amplifying and analog digital conversion, exports digital Far-infrared thermography;
Described image processing system, for described visible images and Far-infrared thermography registration are merged, by the display of identical proportional sizes, the blood-vessel image of outputting high quality.
2. as claimed in claim 1 for detecting the device of blood vessel, it is characterized in that, described fiber coupler comprises fixed cover, condenser lens and optical branching device, described visible light source is fixed in fixed cover, the direction of advance of visible ray installs condenser lens and optical branching device successively, one end of optical branching device is fixedly connected with fixed cover, the other end of optical branching device is connected with lighting fiber, described lighting fiber is in the periphery of imaging receiver passage, described imaging receiver passage comprises circular tube shaped passage and collimating lens, collimating lens is arranged at the bottom of circular tube shaped passage, described infrared light spectroscope is the top that 45° angle is arranged on circular tube shaped passage, the side that circular tube shaped passage is relative with infrared light spectroscope is provided with printing opacity mouth, optical filter is posted at printing opacity mouth place.
3. as claimed in claim 2 for detecting the device of blood vessel, it is characterized in that, visible light source is light emitting diode, and the wavelength of its incident ray is 410-430nm, 525-550nm or 780-800nm; Optical filter identical with the wavelength of incident ray through wavelength.
4. as claimed in claim 2 for detecting the device of blood vessel, it is characterized in that, described circular tube shaped channel interior scribbles anti-reflection coating.
5. as claimed in claim 1 for detecting the device of blood vessel, it is characterized in that, described image processing system has analysis module, for analyzing blood vessel parameter and human body temperature feature.
6. as claimed in claim 1 for detecting the device of blood vessel, it is characterized in that, described device is used for microvascular detection.
7. for detecting a method for blood vessel, it is characterized in that, comprising the following steps:
The visible ray that S1, visible light source send adopts the mode of side incidence to project human tissue surface through lighting fiber;
S2, imaging receiver passage collect the far infrared that the visible ray carrying vessel information of returning through tissue transmission and tissue radiation go out, after the light splitting of infrared light spectroscope, visible ray is transported to visible light lens zoom system, pancreatic system, and far infrared is transported to far infrared lens zoom system;
S3, visible light lens zoom system, pancreatic system project visible light image sensor after being focused on by the visible ray carrying vessel information collected, and obtain blood vessel visible images;
The zoom focal length parameter of visible light lens zoom system, pancreatic system described in S4, far infrared lens zoom system synchronization, projects far infrared deterctor after being focused on by described far infrared, obtains the infrared chart of institute's test set tissue region;
S5, image processing system carry out registration fusion to described visible images and described infrared chart, obtain blood-vessel image.
8. as claimed in claim 7 for detecting the method for blood vessel, it is characterized in that, method for detecting blood vessel also comprises step S6 and utilizes temperature information to analyze the parameter of blood vessel on blood-vessel image, is reflected hemoperfusion degree height and the velocity of blood flow of tissue by the height of tissues surrounding vascular temperature.
9. as claimed in claim 8 for detecting the method for blood vessel, it is characterized in that, step S6 also comprises and utilizes the temperature profile of temperature information to tissue to analyze: utilize erythrocyte to the principle of absorption of visible ray to while blood vessel imaging, also utilize the tissue temperature field distribution of far infrared deterctor testing human and build three-dimensional temperature field mathematical model, obtaining human body temperature feature.
10. as claimed in claim 7 for detecting the method for blood vessel, it is characterized in that, described method is used for microvascular detection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510325800.5A CN104856653B (en) | 2015-06-12 | 2015-06-12 | Apparatus and method for detecting blood vessel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510325800.5A CN104856653B (en) | 2015-06-12 | 2015-06-12 | Apparatus and method for detecting blood vessel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104856653A true CN104856653A (en) | 2015-08-26 |
| CN104856653B CN104856653B (en) | 2017-06-30 |
Family
ID=53903167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510325800.5A Active CN104856653B (en) | 2015-06-12 | 2015-06-12 | Apparatus and method for detecting blood vessel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104856653B (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106060364A (en) * | 2016-07-28 | 2016-10-26 | 浙江宇视科技有限公司 | Optical fog-penetrating color image acquisition method and camera |
| CN106580266A (en) * | 2017-01-24 | 2017-04-26 | 青岛大学附属医院 | Multi-view three-dimensional measurement device for detecting human body microvascular ultramicrostructure |
| CN106725345A (en) * | 2017-01-24 | 2017-05-31 | 青岛大学 | Device for detecting human body microvascular ultrastructure by circular polarization lateral flow dark field imaging technology |
| CN107115099A (en) * | 2017-03-29 | 2017-09-01 | 广州医软智能科技有限公司 | A kind of microcirculation of nail rugae imaging device |
| CN108784664A (en) * | 2018-06-28 | 2018-11-13 | 上海掌门科技有限公司 | Pulse diagnosing device based on pressure sensor and image capture device |
| CN109480791A (en) * | 2018-12-10 | 2019-03-19 | 徐州矿务集团总医院 | A kind of optimization of Cerebral Ischemia-reperfusion in Mice model and lose fruit evaluation method |
| CN110169759A (en) * | 2019-05-28 | 2019-08-27 | Oppo广东移动通信有限公司 | Blood temperature detection method and Related product |
| CN110567582A (en) * | 2018-06-06 | 2019-12-13 | 深圳市凯利博实业有限公司 | body temperature measuring device and method |
| CN110584619A (en) * | 2019-08-30 | 2019-12-20 | 赵宏杰 | Facial skin infrared temperature field detection system based on suspension lens |
| CN111772560A (en) * | 2020-08-06 | 2020-10-16 | 山西医科大学 | Fluorescence endoscope imaging system and method based on dual-channel efficient transmission |
| CN112587105A (en) * | 2020-12-11 | 2021-04-02 | 复旦大学附属中山医院 | Human body circulation perfusion state evaluation system |
| WO2021143204A1 (en) * | 2020-01-14 | 2021-07-22 | 华为技术有限公司 | Light-splitting flat panel, light-splitting device, light-splitting lens, camera, and electronic device |
| CN113786168A (en) * | 2021-09-10 | 2021-12-14 | 复旦大学附属中山医院 | Light source system capable of distinguishing blood vessels in adipose tissues during operation |
| US11864909B2 (en) | 2018-07-16 | 2024-01-09 | Bbi Medical Innovations, Llc | Perfusion and oxygenation measurement |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105825516B (en) * | 2016-03-25 | 2018-06-19 | 上海慧达医疗器械有限公司 | A kind of DICOM images blood flow analysis system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050033185A1 (en) * | 2003-08-06 | 2005-02-10 | Cytometrics, Llc | Method for correcting vessel and background light intensities used in beer's law for light scattering in tissue |
| CN103417196A (en) * | 2013-08-23 | 2013-12-04 | 中山大学 | Venous visualizer and visualizing method |
| CN103445764A (en) * | 2013-09-04 | 2013-12-18 | 广州医软智能科技有限公司 | Device and method for monitoring microcirculation imaging |
| CN204318721U (en) * | 2014-11-24 | 2015-05-13 | 广州呼研所红外科技有限公司 | A kind of peripheral vascular disease thermal image detection device |
| CN204734466U (en) * | 2015-06-12 | 2015-11-04 | 广州医软智能科技有限公司 | Be used for detecting hematal device |
-
2015
- 2015-06-12 CN CN201510325800.5A patent/CN104856653B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050033185A1 (en) * | 2003-08-06 | 2005-02-10 | Cytometrics, Llc | Method for correcting vessel and background light intensities used in beer's law for light scattering in tissue |
| CN103417196A (en) * | 2013-08-23 | 2013-12-04 | 中山大学 | Venous visualizer and visualizing method |
| CN103445764A (en) * | 2013-09-04 | 2013-12-18 | 广州医软智能科技有限公司 | Device and method for monitoring microcirculation imaging |
| CN204318721U (en) * | 2014-11-24 | 2015-05-13 | 广州呼研所红外科技有限公司 | A kind of peripheral vascular disease thermal image detection device |
| CN204734466U (en) * | 2015-06-12 | 2015-11-04 | 广州医软智能科技有限公司 | Be used for detecting hematal device |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106060364A (en) * | 2016-07-28 | 2016-10-26 | 浙江宇视科技有限公司 | Optical fog-penetrating color image acquisition method and camera |
| CN106725345B (en) * | 2017-01-24 | 2023-08-11 | 青岛大学 | Device for detecting human microvascular ultrastructure by using circular polarization sidestream dark field imaging technology |
| CN106580266A (en) * | 2017-01-24 | 2017-04-26 | 青岛大学附属医院 | Multi-view three-dimensional measurement device for detecting human body microvascular ultramicrostructure |
| CN106725345A (en) * | 2017-01-24 | 2017-05-31 | 青岛大学 | Device for detecting human body microvascular ultrastructure by circular polarization lateral flow dark field imaging technology |
| CN106580266B (en) * | 2017-01-24 | 2024-03-29 | 青岛大学附属医院 | Multi-eye three-dimensional measuring device for detecting human body microvascular ultrastructure |
| CN107115099A (en) * | 2017-03-29 | 2017-09-01 | 广州医软智能科技有限公司 | A kind of microcirculation of nail rugae imaging device |
| CN110567582A (en) * | 2018-06-06 | 2019-12-13 | 深圳市凯利博实业有限公司 | body temperature measuring device and method |
| CN108784664A (en) * | 2018-06-28 | 2018-11-13 | 上海掌门科技有限公司 | Pulse diagnosing device based on pressure sensor and image capture device |
| CN108784664B (en) * | 2018-06-28 | 2024-09-24 | 上海掌门科技有限公司 | Pulse feeling device based on pressure sensor and image acquisition equipment |
| US11864909B2 (en) | 2018-07-16 | 2024-01-09 | Bbi Medical Innovations, Llc | Perfusion and oxygenation measurement |
| CN109480791A (en) * | 2018-12-10 | 2019-03-19 | 徐州矿务集团总医院 | A kind of optimization of Cerebral Ischemia-reperfusion in Mice model and lose fruit evaluation method |
| CN110169759A (en) * | 2019-05-28 | 2019-08-27 | Oppo广东移动通信有限公司 | Blood temperature detection method and Related product |
| CN110584619A (en) * | 2019-08-30 | 2019-12-20 | 赵宏杰 | Facial skin infrared temperature field detection system based on suspension lens |
| EP4063940A4 (en) * | 2020-01-14 | 2023-01-18 | Huawei Technologies Co., Ltd. | Light-splitting flat panel, light-splitting device, light-splitting lens, camera, and electronic device |
| WO2021143204A1 (en) * | 2020-01-14 | 2021-07-22 | 华为技术有限公司 | Light-splitting flat panel, light-splitting device, light-splitting lens, camera, and electronic device |
| CN111772560A (en) * | 2020-08-06 | 2020-10-16 | 山西医科大学 | Fluorescence endoscope imaging system and method based on dual-channel efficient transmission |
| CN112587105B (en) * | 2020-12-11 | 2023-10-27 | 复旦大学附属中山医院 | Human body circulatory perfusion state evaluation system |
| CN112587105A (en) * | 2020-12-11 | 2021-04-02 | 复旦大学附属中山医院 | Human body circulation perfusion state evaluation system |
| CN113786168A (en) * | 2021-09-10 | 2021-12-14 | 复旦大学附属中山医院 | Light source system capable of distinguishing blood vessels in adipose tissues during operation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104856653B (en) | 2017-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104856653B (en) | Apparatus and method for detecting blood vessel | |
| US10314490B2 (en) | Method and device for multi-spectral photonic imaging | |
| CN204734466U (en) | Be used for detecting hematal device | |
| EP2640254B1 (en) | In-vivo imaging device and method for performing spectral analysis | |
| Sharma et al. | Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications | |
| CN102028477B (en) | Device and method for measuring blood oxygen saturation of eye fundus retina | |
| US20050194537A1 (en) | Integrated multi-spectral imaging systems and methods of tissue analyses using same | |
| US20170224220A1 (en) | Multi-modal fiber optic probe and spectroscopy system | |
| CN101019758A (en) | Non-invasive early cervical carcinoma detecting infrared diffused ray system and method | |
| JP4216893B2 (en) | Biological component concentration measuring device | |
| CN101194828B (en) | Nondestructive optics detecting device for Eye aqueous glucose concentration | |
| CN102946794A (en) | Device and method for detecting and monitoring ingredients or properties of a measurement medium, in particular of physiological blood values | |
| CN107941782B (en) | It can endoscopic fiber Raman microprobe and detection device | |
| CN104997519B (en) | Dual-wavelength retinal blood vessel blood oxygen measurement system based on fundus camera | |
| EP3417763A1 (en) | System for endoscopic imaging | |
| Luthman et al. | Bimodal reflectance and fluorescence multispectral endoscopy based on spectrally resolving detector arrays | |
| US20140163389A1 (en) | In vivo detection of eosinophils | |
| CN104535481A (en) | Imaging flow cytometer | |
| CN109820480A (en) | A kind of endogenous optical signal and multi-wavelength flow imaging system | |
| KR20070083854A (en) | Ir spectrographic apparatus and method for diagnosis of disease | |
| CN205317664U (en) | Detection device who lacks blood brain tissue based on reflective formation of image of terahertz wave | |
| Li et al. | Edge detection of heterogeneity in transmission images based on frame accumulation and multiband information fusion | |
| CN102599883B (en) | Dual-band optical coherence tomography imaging system for examining early lesion | |
| CN105996995B (en) | A kind of tympanitis diagnostic system and instrument based on spectral technique | |
| CN115177244A (en) | Micro non-invasive blood glucose detection system based on differential Raman spectrum |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |