CN104856640A - Laser-induced plasma spectral analysis device and method for corneal measurement - Google Patents
Laser-induced plasma spectral analysis device and method for corneal measurement Download PDFInfo
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- CN104856640A CN104856640A CN201510262847.1A CN201510262847A CN104856640A CN 104856640 A CN104856640 A CN 104856640A CN 201510262847 A CN201510262847 A CN 201510262847A CN 104856640 A CN104856640 A CN 104856640A
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Abstract
The invention relates to the technical field of laser ophthalmic surgery, in particular to a laser-induced plasma spectral analysis device for corneal measurement. The device comprises a laser, a light beam quality adjusting system, a light beam refraction system, a light filtering system, a telescope system, a detection point distance dynamic monitoring system, a feedback adjusting and controlling system, an echelle grating spectrograph, an integral delay detection system and a computer. The invention further discloses a method for corneal measurement by means of the device. By means of the laser-induced plasma spectral analysis device and method for corneal measurement, biomechanical parameters of corneas can be quickly and accurately obtained, and requirements for detected persons are low.
Description
Technical field
The present invention relates to laser eye surgery technical field, particularly a kind of Laser induced plasma spectroscopy analytical equipment for cornea measurement and method.
Background technology
For being not suitable for the patient carrying out laser eye surgery, modal reason easily occurs keratoconus, and keratoconus is also a kind of main clinical manifestation of current laser eye surgery failure.Whether easily occurring keratoconus to patient, is the problem that laser eye surgery must be considered.
Whether patient is easily occurred that its biological mechanics parameter of patient is mainly measured in the inspection of keratoconus, because its biological mechanics parameter of keratoconus is all lower than normal value at present.
And can the instrument of somatometry its biological mechanical property be uniquely at present ophthalmoreaction analyser clinically.The measuring method of ophthalmoreaction analyser is similar to traditional non-contact tonometer: allow patient be placed on instrument support by lower jaw, fixing head, open eyes wide as far as possible, green flashing sign in test eye fixation instrument, press " measurement " button, instrument probe from motion tracking close test eye, and blows out one gas pressing cornea, records series of parameters.On the same day using ophthalmoreaction analyser to measure, must get rid of any to the infringement operation of test eye and the use of eye eye drop, and tester must quiet, loosen environment and knowledge under measure.Usually each check measurement 3 times, when measurement data exists notable difference, also increases pendulous frequency to 5 time or more, gets its meansigma methods.
As from the foregoing, when measuring cornea biomechanical property with current ophthalmoreaction analyser, there is the problem measured and affect by several factors, especially the state of patient itself is very large on the impact of measurement result, causes the preoperative planning efficiency of laser surgery very low.
Summary of the invention
The present invention is intended to overcome existing ophthalmoreaction analyser technological deficiency existing in its biological mechanics properties testing, a kind of novel Laser induced plasma spectroscopy analytical equipment for cornea measurement and method are provided, when adopting this equipment to obtain its biological mechanics parameter, require lower to detected person and can obtain rapidly.
For achieving the above object, the present invention is by the following technical solutions:
On the one hand, the invention provides a kind of Laser induced plasma spectroscopy analytical equipment measured for cornea, comprise: laser instrument, beam quality regulating system, light beam steering system, filter system, telescopic system, test point distance dynamic monitoring system, feedback regulation control system, echelle spectrometer, integrated delay detection system and computer; Described beam quality regulating system is for controlling the output intensity of laser beam; Described light beam steering system is used for turning back and controls the laser light velocity; Described test point distance dynamic monitoring system is for detecting the distance of cornea to telescopic system; Described feedback regulation control system is for controlling telescopic system; Described telescopic system, for regulating the focal position of laser, makes laser focusing on cornea, forms plasma optical signal at anterior corneal surface; Described filter system is used for plasma optical signal and carries out noise reduction process; The plasma optical signal that described echelle spectrometer is used for gathering carries out spectrum analysis; Described integrated delay detection system, for the treatment of the plasma optical signal gathered, obtains quantitative spectral information.
Preferably, the optical maser wavelength that described laser instrument is launched is 1064nm.
Preferably, the optical maser wavelength that described laser instrument is launched is 266nm.
Preferably, described filter system comprises filter lens; Described filter lens surface is provided with highly reflecting films.
Preferably, the reflectance of described highly reflecting films is not less than 99.99%.
Preferably, described highly reflecting films are for carry out high reverse--bias to laser beam, and reflectance is 99.99%.
Preferably, described highly reflecting films are plated on described filter lens surface by the mode of plating.
Preferably, described telescopic system comprises convex reflecting mirror and concave mirror, by the position regulating the distance between described convex reflecting mirror and described concave mirror to regulate laser focusing.
Preferably, described test point distance dynamic monitoring system comprises the one in single frequency laser interferometer, two-frequency laser interferometer or laser range finder.
On the other hand, the invention provides a kind of method utilizing the said equipment to carry out cornea measurement, comprising: a. laser instrument Emission Lasers, laser focuses to cornea place by described telescopic system, makes anterior corneal surface form plasma signal; B. described plasma signal is by after described filter system process, the plasma optical signal gathered by described integrated delay detection system process, then carries out spectrum analysis by described echelle spectrometer; C. the mechanical property of cornea is judged by Spectroscopic analysis results.
Beneficial effect of the present invention is: provide a kind of Laser induced plasma spectroscopy analytical equipment for cornea measurement and method, the biomechanical parameter of cornea accurately can be obtained again fast by this equipment, biomechanical parameter specifically comprises the intensity etc. that cornea produces laser induced plasma signal, and this equipment requires lower to detected person.
Accompanying drawing explanation
The structural representation of the equipment of Fig. 1 one embodiment of the invention;
Fig. 2 is plasma spectrum figure according to an embodiment of the invention.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and the specific embodiments, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, and be not construed as limiting the invention.
First with reference to figure 1, show according to an embodiment of the invention for the Laser induced plasma spectroscopy analytical equipment of cornea measurement, comprise: laser instrument 1, beam quality regulating system 2, light beam steering system 3, filter system, telescopic system, test point distance dynamic monitoring system 12, feedback regulation control system 13, echelle spectrometer 4, integrated delay detection system 5 and computer 6;
Laser instrument 1 can adopt various types of laser instrument, and the optical maser wavelength that preferred laser 1 is launched can be 1064nm or 266nm.Because the laser wavelength of cornea to 266nm is opaque, when the optical maser wavelength that laser instrument 1 is launched is 266nm, the detection for cornea can be safer.
Beam quality regulating system 2 mainly makes employing one for detecting the speckle analysis instrument of optical quality, by the ECU of speckle analysis instrument and 1 li, laser instrument is connected, the output state that the size controlling laser device laser medium pumping current regulates laser beam final, especially the output intensity etc. of laser beam, guarantees to export optimized laser beam quality.
Light beam steering system 3 is mainly used for control laser beam of turning back, and can be made up of one or more reflecting mirror.
Telescopic system, for regulating the focal position of laser, makes laser focusing on cornea, forms plasma signal at anterior corneal surface; Telescopic system can be made up of convex reflecting mirror 8 and concave mirror 9, and by regulating the distance between concave mirror 9 and convex reflecting mirror 8, just can regulate the position of laser focusing easily, wherein, concave mirror 9 is structures that there is round hole a centre.
Test point distance dynamic monitoring system 12 is mainly for detection of the distance of cornea to telescopic system.By adopting single-frequency or two-frequency laser interferometer, the laser ranging instruments such as laser range finder, real-time precise monitoring patient cornea is to the distance of convex reflecting mirror 8, and carry out the distance between regulating and controlling concave mirror 9 and convex reflecting mirror 8 by feedback regulation control device 13, dynamically ensure that laser focusing is on detected cornea 14.
Feedback regulation control device 13 comprises an electric control structure, be mainly used in controlling telescopic system, receiving detected cornea 14 that test point distance dynamic monitoring system 12 provides after the distance of convex reflecting mirror 8, can by the position regulating electro-motor to change convex reflecting mirror 8, realize the distance between regulating and controlling concave mirror 9 and convex reflecting mirror 8, dynamically ensure that laser focusing is on detected cornea 14.
Filter system is mainly used in plasma optical signal and carries out noise reduction process.Concrete, filter system comprises filter lens; Filter lens surface is provided with highly reflecting films.More specifically, the filter lens that surface is provided with highly reflecting films comprises the lens 7 with light-filtering characteristic and the dichroic mirror 10 with light-filtering characteristic.The lens 7 with light-filtering characteristic obtain by arranging highly reflecting films at lens surface, the optical signal that can be different from the plasma light signal in band of cornea 14 for other carries out quantitative absorption, the stability of the plasma light spectrum signal by echelle spectrometer 4 is effectively controlled with strong and weak contrast, thus improves signal to noise ratio.The dichroic mirror 10 with light-filtering characteristic obtains by arranging highly reflecting films in mirror surface, can carry out noise reduction process by plasma optical signal.
Preferred embodiment, the reflectance of the highly reflecting films adopted is not less than 99.99%.Highly reflecting films specifically can be and carry out high reverse--bias to laser beam, reflectance 99.99%.Highly reflecting films can be plated on filter lens surface by the mode of plating.
In addition, test point distance dynamic monitoring system 12 also comprises the reflecting mirror 11 for focal point position monitoring, and reflecting mirror 11 adopts the reflecting mirror that plasma optical signal can be allowed to pass through.
The plasma optical signal that echelle spectrometer 4 in equipment is mainly used in gathering carries out spectrum analysis, can commercially obtain.Integrated delay detection system 5, mainly for the treatment of the plasma optical signal gathered, obtains quantitative spectral information.Computer 6 is for controlling each system of whole equipment, and comprise and control laser instrument 1 whether bright dipping, when echelle spectrometer 4 carries out spectra collection and date processing etc., specifically can adopt normally used PC etc.
In detailed description of the invention, the process utilizing this equipment to carry out when cornea is measured is:
A. laser instrument Emission Lasers, laser focuses to cornea place by described telescopic system, makes anterior corneal surface form plasma signal;
B. described plasma signal is by after described filter system process, the plasma optical signal gathered by described integrated delay detection system process, then carries out spectrum analysis by described echelle spectrometer;
C. the mechanical property of cornea is judged by Spectroscopic analysis results.
The Laser induced plasma spectroscopy analytical equipment for cornea measurement that present embodiment provides and method, accurately can obtain again the bio-mechanical property of cornea fast, as whether normal etc. in can be judged the bio-mechanical property of cornea by the intensity of laser induced plasma signal; And require lower to detected person, be a kind of novel pachymetry device.
Adopt the Laser induced plasma spectroscopy analytical equipment measured for cornea that present embodiment provides, the spectrogram that observation obtains as shown in Figure 2, as can be seen from spectrogram, only to should have cornea tissue there is the spectrum of element, not there are other materials, as use in operation lubricating fluid, in operation with the optics etc. of the direct close contact of cornea, the corresponding spectrum of the element had.Absolutely prove, adopt Apparatus and method for of the present invention, can more accurately, obtained the biomechanical property parameter of cornea easily by the intensity of gained spectral signal.
The above the specific embodiment of the present invention, does not form limiting the scope of the present invention.Any various other done by technical conceive of the present invention change and distortion accordingly, all should be included in the protection domain of the claims in the present invention.
Claims (10)
1. the Laser induced plasma spectroscopy analytical equipment measured for cornea, it is characterized in that, comprise: laser instrument, beam quality regulating system, light beam steering system, filter system, telescopic system, test point distance dynamic monitoring system, feedback regulation control system, echelle spectrometer, integrated delay detection system and computer;
Described beam quality regulating system is for controlling the output intensity of laser beam;
Described light beam steering system is used for control laser beam of turning back;
Described test point distance dynamic monitoring system is for detecting the distance of cornea to telescopic system;
Described feedback regulation control system is for controlling telescopic system;
Described telescopic system, for regulating the focal position of laser, makes laser focusing on cornea, forms plasma optical signal at anterior corneal surface;
Described filter system is used for plasma optical signal and carries out noise reduction process;
The plasma optical signal that described echelle spectrometer is used for gathering carries out spectrum analysis;
Described integrated delay detection system, for the treatment of the plasma optical signal gathered, obtains quantitative spectral information.
2. as claimed in claim 1 for the Laser induced plasma spectroscopy analytical equipment that cornea is measured, it is characterized in that, the optical maser wavelength that described laser instrument is launched is 1064nm.
3. as claimed in claim 1 for the Laser induced plasma spectroscopy analytical equipment that cornea is measured, it is characterized in that, the optical maser wavelength that described laser instrument is launched is 266nm.
4., as claimed in claim 1 for the Laser induced plasma spectroscopy analytical equipment that cornea is measured, it is characterized in that, described filter system comprises filter lens; Described filter lens surface is provided with highly reflecting films.
5., as claimed in claim 4 for the Laser induced plasma spectroscopy analytical equipment that cornea is measured, it is characterized in that, the reflectance of described highly reflecting films is not less than 99.99%.
6., as claimed in claim 4 for the Laser induced plasma spectroscopy analytical equipment that cornea is measured, it is characterized in that, described highly reflecting films carry out high reverse--bias to laser beam, and reflectance is 99.99%.
7. as claimed in claim 4 for the Laser induced plasma spectroscopy analytical equipment that cornea is measured, it is characterized in that, described highly reflecting films are plated on described filter lens surface by the mode of plating.
8. as claimed in claim 1 for the Laser induced plasma spectroscopy analytical equipment of cornea measurement, it is characterized in that, described telescopic system comprises convex reflecting mirror and concave mirror, by the position regulating the distance between described convex reflecting mirror and described concave mirror to regulate laser focusing.
9. as claimed in claim 1 for the Laser induced plasma spectroscopy analytical equipment that cornea is measured, it is characterized in that, described test point distance dynamic monitoring system comprises the one in single frequency laser interferometer, two-frequency laser interferometer or laser range finder.
10. utilize equipment described in claim 1 to carry out a method for cornea measurement, it is characterized in that, comprising:
A. laser instrument Emission Lasers, laser focuses to cornea place by described telescopic system, makes anterior corneal surface form plasma signal;
B. described plasma signal is by after described filter system process, the plasma optical signal gathered by described integrated delay detection system process, then carries out spectrum analysis by described echelle spectrometer;
C. the mechanical property of cornea is judged by Spectroscopic analysis results.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108072634A (en) * | 2016-11-15 | 2018-05-25 | 中国科学院光电研究院 | It is a kind of to survey child's hair to obtain the Laser induced plasma spectroscopy analytical equipment of micro- information |
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| US20130150836A1 (en) * | 2011-06-23 | 2013-06-13 | Amo Development, Llc | Ophthalmic range finding |
| US20140364744A1 (en) * | 2012-12-20 | 2014-12-11 | Wavelight Gmbh | Apparatus, interface unit, suction ring and method to monitor corneal tissue |
| CN104382689A (en) * | 2014-12-02 | 2015-03-04 | 中国科学院光电研究院 | Femtosecond laser system using for imaging and operation at the same time |
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Patent Citations (8)
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| US6592574B1 (en) * | 1999-07-28 | 2003-07-15 | Visx, Incorporated | Hydration and topography tissue measurements for laser sculpting |
| CN1433287A (en) * | 1999-12-23 | 2003-07-30 | 维思克斯公司 | Optical feedback system for vision correction |
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| US8215774B2 (en) * | 2009-04-01 | 2012-07-10 | Tearscience, Inc. | Ocular surface interferometry (OSI) devices and systems for imaging and measuring ocular tear film layer thickness(es) |
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| US20130150836A1 (en) * | 2011-06-23 | 2013-06-13 | Amo Development, Llc | Ophthalmic range finding |
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| CN108072634A (en) * | 2016-11-15 | 2018-05-25 | 中国科学院光电研究院 | It is a kind of to survey child's hair to obtain the Laser induced plasma spectroscopy analytical equipment of micro- information |
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