CN105030413A - Device for detecting laser cutting threshold value of cornea - Google Patents
Device for detecting laser cutting threshold value of cornea Download PDFInfo
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- CN105030413A CN105030413A CN201510313798.XA CN201510313798A CN105030413A CN 105030413 A CN105030413 A CN 105030413A CN 201510313798 A CN201510313798 A CN 201510313798A CN 105030413 A CN105030413 A CN 105030413A
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Abstract
The invention relates to the technical field of laser ophthalmologic operation, and provides a method and a device for detecting a laser cutting threshold value of the cornea. According to the device, a laser light source generated by a laser module irradiates a sample on a sample module so as to generate laser-induced plasma signals and second harmonic signals, a laser-induced plasma signal collection module collects the laser-induced plasma signals, a second harmonic signal collection module collects the second harmonic signals, the laser module, the laser-induced plasma signal collection module and the second harmonic signal collection module are respectively electrically connected with a data processing module, the data processing module receives the signals collected by the laser-induced plasma signal collection module and the second harmonic signal collection module, and takes a threshold value obtained by measurement before the laser-induced plasma signals appear and when the second harmonic signals are reduced. The method and the device can accurately measure the femtosecond laser cutting threshold value of the cornea.
Description
[technical field]
The present invention relates to laser eye surgery technical field, particularly relate to a kind of device detecting cornea laser cutting threshold value.
[background technology]
Past 10 years, owing to having accurate cutting precision and minimized side effect effect, the development of femtosecond laser area of ophthalmic surgery is very rapid, have wide potential applicability in clinical practice, that has applied in actual operation comprises femtosecond laser corneal graft and femtosecond laser original position keratomileusis.In order to obtain best surgical effect, the femto-second laser pulse energy demand used in operation as much as possible close to and a little more than corneal laser ablation threshold.Accurate femtosecond laser cornea ablation threshold value of measuring in real time has very urgent application demand for operation application.
Measurement femtosecond laser cornea ablation threshold method conventional at present measures cornea laser cutting threshold value by laser induced plasma optical signal, its principle is for using photomultiplier tube to monitor laser induced plasma optical signal with cutting laser vertical direction, while increasing incident cutting laser energy gradually, whether monitoring laser induced plasma optical signal occurs, the laser energy when incidence cutting laser energy corresponding when laser induced plasma optical signal occurs is exactly threshold value.Whether accurately the method, because detection optical signal is in cutting parallel light direction, can apply in operation, but there is measurement problem.Due in actual operation, with the ablation threshold of the ablation threshold of the optics of the direct close contact of cornea and cornea closely, and the thickness of people's cornea itself only has again half millimeter, therefore probably there is the deviation because precision focuses on and the ablation threshold of optics be used as the ablation threshold of cornea, in the optics with the direct close contact of cornea, measuring by laser focusing that to obtain that threshold value takes for be the ablation threshold of cornea.
Therefore, in the urgent need to developing a kind of device of the detection cornea laser cutting threshold value that can be applied in actual operation, femtosecond laser cornea ablation threshold value can be measured exactly, and the ablation threshold of optic value part of close contact direct with cornea in actual operation can not be obscured mutually with the cutting threshold of cornea.
[summary of the invention]
The technical problem to be solved in the present invention is to provide a kind of device of the detection cornea laser cutting threshold value that can be applied in actual operation, femtosecond laser cornea ablation threshold value can be measured exactly, and the ablation threshold of optics of close contact direct with cornea in actual operation can not be obscured mutually with the ablation threshold of cornea.
The present invention adopts following technical scheme:
Detect a device for cornea laser cutting threshold value, described device comprises sample block (100), laser module (200), laser induced plasma signal acquisition module (300), second harmonic signal acquisition module (400) and data processing module (500);
The sample that the LASER Light Source that described laser module (200) produces is irradiated to sample block (100) produces laser induced plasma signal and second harmonic signal, laser induced plasma signal acquisition module (300) gathers described laser induced plasma signal, and second harmonic signal acquisition module (400) gathers described second harmonic signal;
Described laser module (200), laser induced plasma signal acquisition module (300) and second harmonic signal acquisition module (400) are electrically connected with data processing module (500) respectively, data processing module (500) receives laser induced plasma signal acquisition module (300) and the signal that gathers of second harmonic signal acquisition module (400), using before laser induced plasma signal occurs, second harmonic signal reduction time the threshold value that obtains of measurement as corneal laser ablation threshold.
Further, described laser module (200) comprises the laser element (201), incident laser light intensity adjusting device (202), beam expander (203), spectroscope (204) and the first plus lens (205) that set gradually along laser optical path; The laser that laser element (201) sends carries out regulating continuously through incident laser light intensity adjusting device (202) from weak to strong, carry out diameter broadening through beam expander (203) to incident laser beam again, the laser beam after spectroscope (204) converges on the sample of sample block (100) by the first plus lens (205);
Described laser induced plasma signal produces at the focused spot place of described first plus lens (205).
Further, described laser element (201) comprises 3 laser instrument: Nd:glass femto-second laser, Yb:KYW femto-second laser and Nd:YAG picosecond laser.
Further, described incident laser light intensity adjusting device (202) is made up of half-wave plate and polaroid.
Further, described first plus lens (205) be numerical aperture 0.12, the plus lens of amplification 5 times.
Further, described laser induced plasma signal acquisition module (300) comprises the first photomultiplier tube (301), second harmonic filter plate (302) and the first near-infrared filter plate (303) that set gradually;
The laser induced plasma light of the focused spot place generation of described first plus lens is after spectroscope, the laser beam in laser induced plasma Signal transmissions light path is blocked through the first near-infrared filter plate, the second harmonic signal in laser induced plasma Signal transmissions light path is blocked again, finally by the first photomultiplier tube collection laser induced plasma signal wherein through second harmonic filter plate.
Further, described second harmonic signal acquisition module (400) comprises the second photomultiplier tube (401), narrow band filter slice (402), the second near-infrared filter plate (403) and the second plus lens (404) that set gradually;
The focused spot place of described second plus lens (404) produces described second harmonic signal, second harmonic signal blocks the laser beam in second harmonic signal transmission light path through the second near-infrared filter plate (403), again through all the other signals of narrow band filter slice (402) filtering, finally gathered by the second photomultiplier tube (401).
Further, described second plus lens (404) be numerical aperture 0.40, the plus lens of amplification 20 times.
Further, described sample block (100) comprises the cornea sample of upper and lower layer glass microscope slide and middle clamping.
Further, the laser induced plasma light that produces for the focused spot place of refractive laser and transmission first plus lens (205) of described spectroscope (204).
Compared with prior art, beneficial effect of the present invention is: device provided by the invention can be applied in actual operation, femtosecond laser cornea ablation threshold value can be measured exactly, and the ablation threshold of optics of close contact direct with cornea in actual operation can not be obscured mutually with the ablation threshold of cornea.The present invention passes through the second harmonic signal that Laser Measurement induced plasma optical signal and cornea tissue simultaneously produce femtosecond laser, because second harmonic signal only can be produced by cornea, can not produce with the optics of the direct close contact of cornea by actual operation, stop the problem ablation threshold of optics of close contact direct with cornea in actual operation obscured mutually with the ablation threshold of cornea.
[accompanying drawing explanation]
Fig. 1 is the apparatus structure block diagram of the detection cornea laser cutting threshold value that the embodiment of the present invention provides;
Fig. 2 is the index path of the device of the detection cornea laser cutting threshold value that the embodiment of the present invention provides;
Fig. 3 is the measuring principle figure adopting the embodiment of the present invention to carry out the detection of corneal laser ablation threshold;
Fig. 4 is the oscilloscope signal figure adopting the embodiment of the present invention to carry out the detection of corneal laser ablation threshold;
Fig. 5 is the measurement result figure adopting the embodiment of the present invention to carry out the detection of corneal laser ablation threshold.
Reference numeral is as follows:
100-sample block; 200-laser module; 201-laser element; 202-incident laser light intensity adjusting device; 203-beam expander; 204-spectroscope; 205-first plus lens; 300-laser induced plasma signal acquisition module; 301-first photomultiplier tube; 302-second harmonic filter plate; 303-first near-infrared filter plate; 400-second harmonic signal acquisition module; 401-second photomultiplier tube; 402-narrow band filter slice; 403-second near-infrared filter plate; 404-second plus lens; 500-data processing module.
[detailed description of the invention]
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
In addition, if below in described each embodiment of the present invention involved technical characteristic do not form conflict each other and just can mutually combine.
In accompanying drawing of the present invention, as without special suggestion, single arrow represents laser optical path, and solid line double-head arrow represents laser induced plasma light path, and dashed double represents second harmonic signal light path.
Embodiments provide a kind of device detecting cornea laser cutting threshold value, by monitoring laser induced plasma optical signal and cornea tissue detects cornea laser cutting threshold value to the second harmonic signal that femtosecond laser produces simultaneously.As shown in Figure 1, this device comprises sample block 100, laser module 200, laser induced plasma signal acquisition module 300, second harmonic signal acquisition module 400 and data processing module 500.Wherein sample block 100 comprises the cornea sample of upper and lower layer glass microscope slide and middle clamping, and data processing module 500 can be computer or similar device.
The sample that the LASER Light Source that laser module 200 produces is irradiated to sample block 100 produces laser induced plasma signal and second harmonic signal, laser induced plasma signal acquisition module 300 gathers laser induced plasma signal, and second harmonic signal acquisition module 400 gathers second harmonic signal; Laser module 200, laser induced plasma signal acquisition module 300 and second harmonic signal acquisition module 400 are electrically connected with data processing module 500 respectively, data processing module 500 receives the signal that laser induced plasma signal acquisition module 300 and second harmonic signal acquisition module 400 gather, using before laser induced plasma signal occurs, second harmonic signal reduce time the threshold value that obtains of measurement as corneal laser ablation threshold.
Below the concrete structure of the device of this detection cornea laser cutting threshold value is described further, please refer to shown in Fig. 2, laser module 200 comprises the laser element 201, incident laser light intensity adjusting device 202, beam expander 203, spectroscope 204 and the first plus lens 205 that set gradually along laser optical path; In this enforcement, laser element 201 comprises 3 ultrafast laser systems: Nd:glass femto-second laser, Yb:KYW femto-second laser and Nd:YAG picosecond laser, provides the laser pulse width excursion from 800 femtoseconds to 20 psecs.The laser that laser instrument sends carries out regulating continuously through incident laser light intensity adjusting device 202 from weak to strong, carry out diameter broadening through beam expander 203 pairs of incident laser beam again, thus make laser beam can be full of the aperture of the first plus lens 205 below completely.Then, the laser beam after spectroscope 204 reflects converges on the cornea sample of sample block 100 by the first plus lens 205; Laser induced plasma signal produces at the focused spot place of the first plus lens 205, and also namely the first plus lens 205 is also collected in the laser induced plasma signal of its focused spot place generation while laser beam is converged to cornea sample.Wherein: incident laser light intensity adjusting device 202 is made up of half-wave plate and polaroid, the first plus lens 205 is the plus lens of numerical aperture 0.12, amplification 5 times.
As shown in Figure 2, laser induced plasma signal acquisition module 300 comprises the first photomultiplier tube 301, second harmonic filter plate 302 and the first near-infrared filter plate 303 that set gradually; The laser induced plasma light of the focused spot place generation of the first plus lens 205 is after spectroscope 204 transmission, the laser beam in laser induced plasma Signal transmissions light path is blocked through the first near-infrared filter plate 303, block the second harmonic signal in laser induced plasma Signal transmissions light path through second harmonic filter plate 302 again, finally gathered laser induced plasma signal wherein by the first photomultiplier tube 301.
As shown in Figure 2, second harmonic signal acquisition module 400 comprises the second photomultiplier tube 401, narrow band filter slice 402, second near-infrared filter plate 403 and the second plus lens 404 that set gradually; The focused spot place of the second plus lens 404 produces second harmonic signal, and also namely the second plus lens 404 is used for the second harmonic signal that collection angle membrane sample produces at its focused spot place.Then, second harmonic signal blocks the laser beam in second harmonic signal transmission light path through the second near-infrared filter plate 403, then through all the other signals of narrow band filter slice 402 filtering, is finally gathered by the second photomultiplier tube 401.Wherein, the second plus lens 404 is the plus lens of numerical aperture 0.40, amplification 20 times.
Below principle of the present invention is elaborated: on definition and laser beam irradiation to cornea sample, equidirectional light path is input path, and this laser beam is reflected light path against the light path in turnback direction.The first near-infrared filter plate 303 then on reflected light path and second harmonic filter plate 302 are used for ensureing the induced with laser gas ions signal such as to only have gathered by the first photomultiplier tube 301 in this light path.The second near-infrared filter plate 403 in input path and narrow band filter slice 402 are used for ensureing to only have second harmonic signal to be gathered by the second photomultiplier tube 401 in this light path.As shown in Figure 3, laser induced plasma optical signal occurs measuring principle after the light intensity of incident laser reaches threshold value, strengthens along with the enhancing of incident intensity.The second harmonic signal that cornea produces will produce before the light intensity of incident laser reaches threshold value, when the light intensity of incident laser reaches threshold value, cornea tissue due to focused spot place is in plasma and disappears, the signal of second harmonic reduces on the contrary, becomes the mark that obvious threshold value arrives.The different variation tendencies produced in conjunction with these two kinds of signals increase with incident laser light intensity, just accurately can determine the laser cutting threshold value of cornea tissue.Because second harmonic signal only can be produced by cornea tissue, so can determine that laser focuses on cornea tissue by this signal of monitoring, owing to creating cutting effect in the threshold value moment, the cornea tissue at laser focusing focus place is in plasma and disappears, second harmonic signal intensity can diminish, and just can determine the laser cutting threshold value of cornea exactly.
The second harmonic signal that device provided by the invention produces by gathering cornea while collection laser induced plasma signal, determines the laser cutting threshold value of cornea exactly in conjunction with these two kinds of signals.And the method for existing measurement femtosecond laser cornea ablation threshold value measures cornea laser cutting threshold value by laser induced plasma optical signal, easily the ablation threshold of optics of close contact direct with cornea in actual operation is obscured mutually with the ablation threshold of cornea, namely measuring in optics, to obtain that threshold value takes for be the ablation threshold of cornea.Due in actual operation and the ablation threshold of the ablation threshold of optics of the direct close contact of cornea and cornea closely, and the thickness of people's cornea itself only has half millimeter, therefore just determine that the ablation threshold of cornea probably appears due to the deviation of precision focusing, the ablation threshold of optics being used as in the method for cornea threshold value only by Laser Measurement induced plasma signal, namely laser focusing is measured and obtained that threshold value takes in the optics with the direct close contact of cornea is the ablation threshold of cornea, and be not easy to be found to have occurred mistake when measuring.
embody rule:
The device of detection cornea laser cutting threshold value provided by the invention can be used for laser eye surgery, is particularly useful for femtosecond laser corneal graft and femtosecond laser original position keratomileusis.
experimental verification:
We have built experimental provision according to the present invention and have carried out experimental verification.Adopt three kinds of ultrafast laser systems to be used as experimental light sources during experiment, the laser pulse width excursion from 800 femtoseconds to 20 psecs is provided.The light intensity of input laser can realize continuously adjustabe when other experiment parameters (such as laser focusing focus size) are constant.Employing fresh pig cornea sample is fixed on the three-dimensional trim holder by conputer controlled and tests.By condenser lens and optical filter, gathered by photomultiplier tube at the flashlight of focal position.
As shown in Figure 4, oscillograph screen has three signals from top to bottom: first signal of top represents a single-pulse laser signal; The second harmonic signal that second middle signal representative produces from cornea; 3rd signal of below represents laser induced plasma signal.Adopt device of the present invention, monitor second harmonic signal and laser induced plasma signal simultaneously, when the intensity of incident laser progressively strengthens continuously from being far smaller than cornea threshold value, laser induced plasma optical signal occurs after the light intensity of incident laser reaches threshold value, strengthens along with the enhancing of incident intensity.The second harmonic signal that cornea produces will produce before incident laser light intensity reaches threshold value, when the light intensity of incident laser reaches threshold value, cornea tissue due to focused spot place is in plasma and disappears, and the signal of second harmonic reduces on the contrary, becomes the mark that obvious threshold value arrives.The different variation tendencies produced in conjunction with these two kinds of signals increase with incident laser light intensity, just accurately can determine the laser cutting threshold value of cornea tissue.When incident laser pulsewidth is 800 femtoseconds, 1.6 psecs, 3 psecs and 20 psec, cornea internal measurement laser cutting threshold value result as shown in Figure 5.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. one kind is detected the device of cornea laser cutting threshold value, it is characterized in that, described device comprises sample block (100), laser module (200), laser induced plasma signal acquisition module (300), second harmonic signal acquisition module (400) and data processing module (500);
The sample that the LASER Light Source that described laser module (200) produces is irradiated to sample block (100) produces laser induced plasma signal and second harmonic signal, laser induced plasma signal acquisition module (300) gathers described laser induced plasma signal, and second harmonic signal acquisition module (400) gathers described second harmonic signal;
Described laser module (200), laser induced plasma signal acquisition module (300) and second harmonic signal acquisition module (400) are electrically connected with data processing module (500) respectively, data processing module (500) receives laser induced plasma signal acquisition module (300) and the signal that gathers of second harmonic signal acquisition module (400), using before laser induced plasma signal occurs, second harmonic signal reduction time the threshold value that obtains of measurement as corneal laser ablation threshold.
2. device as claimed in claim 1, it is characterized in that, described laser module (200) comprises the laser element (201), incident laser light intensity adjusting device (202), beam expander (203), spectroscope (204) and the first plus lens (205) that set gradually along laser optical path; The laser that laser element (201) sends carries out regulating continuously through incident laser light intensity adjusting device (202) from weak to strong, carry out diameter broadening through beam expander (203) to incident laser beam again, the laser beam after spectroscope (204) converges on the sample of sample block (100) by the first plus lens (205);
Described laser induced plasma signal produces at the focused spot place of described first plus lens (205).
3. device as claimed in claim 2, it is characterized in that, described laser element (201) comprises 3 laser instrument: Nd:glass femto-second laser, Yb:KYW femto-second laser and Nd:YAG picosecond laser.
4. device as claimed in claim 2, it is characterized in that, described incident laser light intensity adjusting device (202) is made up of half-wave plate and polaroid.
5. device as claimed in claim 2, is characterized in that, described first plus lens (205) is numerical aperture 0.12, the plus lens of amplification 5 times.
6. device as claimed in claim 2, it is characterized in that, described laser induced plasma signal acquisition module (300) comprises the first photomultiplier tube (301), second harmonic filter plate (302) and the first near-infrared filter plate (303) that set gradually;
The laser induced plasma light of the focused spot place generation of described first plus lens is after spectroscope, the laser beam in laser induced plasma Signal transmissions light path is blocked through the first near-infrared filter plate, the second harmonic signal in laser induced plasma Signal transmissions light path is blocked again, finally by the first photomultiplier tube collection laser induced plasma signal wherein through second harmonic filter plate.
7. device as claimed in claim 1, it is characterized in that, described second harmonic signal acquisition module (400) comprises the second photomultiplier tube (401), narrow band filter slice (402), the second near-infrared filter plate (403) and the second plus lens (404) that set gradually;
The focused spot place of described second plus lens (404) produces described second harmonic signal, second harmonic signal blocks the laser beam in second harmonic signal transmission light path through the second near-infrared filter plate (403), again through all the other signals of narrow band filter slice (402) filtering, finally gathered by the second photomultiplier tube (401).
8. device as claimed in claim 7, is characterized in that, described second plus lens (404) is numerical aperture 0.40, the plus lens of amplification 20 times.
9. the device as described in any one of claim 1-8, is characterized in that, described sample block (100) comprises the cornea sample of upper and lower layer glass microscope slide and middle clamping.
10. the device as described in any one of claim 2-6, is characterized in that, the laser induced plasma light that described spectroscope (204) produces for the focused spot place of refractive laser and transmission first plus lens (205).
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| CN201510313798.XA CN105030413B (en) | 2015-06-03 | 2015-06-03 | Device for detecting laser cutting threshold value of cornea |
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| CN201510313798.XA CN105030413B (en) | 2015-06-03 | 2015-06-03 | Device for detecting laser cutting threshold value of cornea |
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| CN105030413B CN105030413B (en) | 2017-03-22 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1957867A (en) * | 2006-11-30 | 2007-05-09 | 上海交通大学 | Intravital surgery system for scanning type laser operation of hot forming cornea |
| US20100292676A1 (en) * | 2006-11-10 | 2010-11-18 | Lars Michael Larsen | Method and apparatus for non-or minimally disruptive photomanipulation of an eye |
| WO2014029407A1 (en) * | 2012-08-22 | 2014-02-27 | Wavelight Gmbh | Corneal tissue detection and monitoring device |
| CN104382689A (en) * | 2014-12-02 | 2015-03-04 | 中国科学院光电研究院 | Femtosecond laser system using for imaging and operation at the same time |
-
2015
- 2015-06-03 CN CN201510313798.XA patent/CN105030413B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100292676A1 (en) * | 2006-11-10 | 2010-11-18 | Lars Michael Larsen | Method and apparatus for non-or minimally disruptive photomanipulation of an eye |
| CN1957867A (en) * | 2006-11-30 | 2007-05-09 | 上海交通大学 | Intravital surgery system for scanning type laser operation of hot forming cornea |
| WO2014029407A1 (en) * | 2012-08-22 | 2014-02-27 | Wavelight Gmbh | Corneal tissue detection and monitoring device |
| CN104382689A (en) * | 2014-12-02 | 2015-03-04 | 中国科学院光电研究院 | Femtosecond laser system using for imaging and operation at the same time |
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