CN104856640B - Laser induced plasma spectroscopy analytical equipment and the method measured for cornea - Google Patents
Laser induced plasma spectroscopy analytical equipment and the method measured for cornea Download PDFInfo
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- CN104856640B CN104856640B CN201510262847.1A CN201510262847A CN104856640B CN 104856640 B CN104856640 B CN 104856640B CN 201510262847 A CN201510262847 A CN 201510262847A CN 104856640 B CN104856640 B CN 104856640B
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Abstract
The present invention relates to laser eye surgery technical field, a kind of Laser induced plasma spectroscopy analytical equipment of measuring for cornea is specifically disclosed, comprise: laser instrument, beam quality regulating system, light beam steering system, filter system, telescopic system, test point is apart from dynamic monitoring system, feedback regulation control system, echelle spectrometer, integration postpones detection system and computer. The present invention also discloses a kind of method of utilizing this equipment to carry out cornea measurement. The Apparatus and method for of measuring for cornea of the present invention, can obtain rapidly and accurately the biomechanical parameter of cornea, and lower to detected person's requirement.
Description
Technical field
The present invention relates to laser eye surgery technical field, particularly a kind of swashing of measuring for corneaPhotoinduction plasma spectroscopy Apparatus and method for.
Background technology
For the patient who is not suitable for carrying out laser eye surgery, modal reason is easily to occur circular coneCornea, keratoconus is also a kind of main clinical manifestation of current laser eye surgery failure. To patientWhether easily occurring keratoconus, is the problem that laser eye surgery must be considered.
At present whether patient is easily occurred to the inspection of keratoconus is mainly the cornea biology of measuring patientMechanics parameter, because the cornea biomechanical parameter of keratoconus is all lower than normal value.
And at present clinically unique instrument that can somatometry cornea biomechanical property be that ophthalmic reaction dividesAnalyse instrument. The measuring method of ophthalmic reaction analyzer is similar to traditional non-contact tonometer: allow patient by lower jawBe placed on instrument support, fixing head is opened eyes wide as far as possible, green flicker in test eye fixation instrumentSignal lamp, presses " measurement " button, and instrument probe near test eye, and blows out one gas from motion trackingBody flattens cornea, records series of parameters. On the same day that uses ophthalmic reaction analyzer to measure, must get rid ofThe use of any operation of the infringement to test eye and eye eye drops, and tester must quiet,Loosen in environment and knowledge situation and measure. Conventionally each check measurement 3 times, measurement data existsWhen notable difference, also increase and measure number of times to 5 time or more, get its mean value.
As from the foregoing, while measuring cornea biomechanical property with current ophthalmic reaction analyzer, exist and surveyProblem, the especially patient's that amount is affected by several factors state itself on the impact of measurement result veryCause the preoperative checking efficiency of laser surgey very low greatly.
Summary of the invention
It is existing in cornea biomechanical property detects that the present invention is intended to overcome existing ophthalmic reaction analyzerTechnological deficiency, provide a kind of novel for cornea measure Laser induced plasma spectroscopy analysis establishStandby and method, while adopting this equipment to obtain cornea biomechanical parameter, requires also lower to detected personAnd can obtain rapidly.
For achieving the above object, the present invention is by the following technical solutions:
On the one hand, the invention provides a kind of Laser induced plasma spectroscopy analysis of measuring for corneaEquipment, comprising: laser instrument, and beam quality regulating system, light beam steering system, filter system, hopesMirror system far away, test point is apart from dynamic monitoring system, feedback regulation control system, echelle grating lightSpectrometer, integration postpones detection system and computer; Described beam quality regulating system is used for controlling sharpThe output intensity of light light beam; Described light beam steering system is used for turning back and controls the laser light velocity; Described detectionPoint arrives the distance of telescopic system for detection of cornea apart from dynamic monitoring system; Described feedback regulation controlSystem processed is used for controlling telescopic system; Described telescopic system is used for regulating the focal position of laser,Make Laser Focusing to cornea, form plasma optical signal at anterior corneal surface; Described filter system is usedCarry out noise reduction process in plasma optical signal; Described echelle spectrometer for to gatherPlasma optical signal carries out spectrum analysis; Described integration postpone detection system for the treatment of gather etc.Gas ions optical signal, obtains quantitative spectral information.
Preferably, the optical maser wavelength of described laser instrument transmitting is 1064nm.
Preferably, the optical maser wavelength of described laser instrument transmitting is 266nm.
Preferably, described filter system comprises optical filtering; Described optical filtering surface is provided with highly reflecting films.
Preferably, the reflectivity of described highly reflecting films is not less than 99.99%.
Preferably, described highly reflecting films are for carrying out height reflection to laser beam, and reflectivity is 99.99%.
Preferably, described highly reflecting films are plated on described optical filtering surface by the mode of electroplating.
Preferably, described telescopic system comprises convex reflecting mirror and concave mirror, by regulating instituteState the position that distance between convex reflecting mirror and described concave mirror regulates Laser Focusing.
Preferably, described test point comprises that apart from dynamic monitoring system single frequency laser interferometer, double frequency swashOne in optical interferometer or laser range finder.
On the other hand, the invention provides a kind of method of utilizing the said equipment to carry out cornea measurement, comprising:A. laser instrument Emission Lasers, laser focuses to cornea place by described telescopic system, makes anterior corneal surface shapeBecome plasma signal; B. after described plasma signal is processed by described filter system, by describedIntegration postpones detection system and processes the plasma optical signal gathering, then by described echelle grating spectrumInstrument carries out spectrum analysis; C. judge the mechanical property of cornea by spectrum analysis result.
Beneficial effect of the present invention is: a kind of laser induced plasma of measuring for cornea is providedSpectral analysis apparatus and method, can accurately obtain again the Biological Strength of cornea fast by this equipmentMathematic(al) parameter, biomechanical parameter specifically comprises that cornea produces the intensity of laser induced plasma signal etc.,And this equipment requires lower to detected person.
Brief description of the drawings
The structural representation of the equipment of Fig. 1 one embodiment of the invention;
Fig. 2 is plasma spectrum figure according to an embodiment of the invention.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with accompanying drawingAnd specific embodiment, the present invention is further elaborated. Should be appreciated that described hereinSpecific embodiment is only in order to explain the present invention, and is not construed as limiting the invention.
First with reference to figure 1, show the laser of measuring for cornea according to an embodiment of the invention and lureLead plasma spectroscopy equipment, comprising: laser instrument 1, beam quality regulating system 2, light beam turnsFolding system 3, filter system, telescopic system, test point is apart from dynamic monitoring system 12, and feedback is adjustedJoint control system 13, echelle spectrometer 4, integration postpones detection system 5 and computer 6;
Laser instrument 1 can adopt various types of laser instruments, and the optical maser wavelength that preferred laser 1 is launched canFor 1064nm or 266nm. Because cornea is opaque to the laser wavelength of 266nm, when laser instrument 1When the optical maser wavelength of transmitting is 266nm, safer for the detection meeting of cornea.
Beam quality regulating system 2 mainly makes to adopt one for surveying the hot spot analyzer of optical quality,By the ECU of 1 li, hot spot analyzer and laser instrument is connected, control laser device laser and be situated betweenThe size of matter pumping current regulates the defeated of laser beam final output state, especially laser beamGo out light intensity etc., guarantee to export optimized laser beam quality.
The light beam steering system 3 control laser beam that is mainly used for turning back, can be by one or more reflectionsMirror forms.
Telescopic system, for regulating the focal position of laser, makes Laser Focusing to cornea, at corneaSurface forms plasma signal; Telescopic system can be by convex reflecting mirror 8 and concave mirror 9Composition, by regulating the distance between concave mirror 9 and convex reflecting mirror 8, just can be easilyThe position that regulates Laser Focusing, wherein, concave mirror 9 is structures that there is round hole a centre.
Test point arrives the distance of telescopic system mainly for detection of cornea apart from dynamic monitoring system 12.By adopting single-frequency or two-frequency laser interferometer, the laser ranging instruments such as laser range finder, accurate in real timeMonitor the distance of patient's cornea to convex reflecting mirror 8, and control by feedback regulation control device 13Regulate the distance between concave mirror 9 and convex reflecting mirror 8, dynamically ensure that Laser Focusing is at quiltOn the cornea 14 detecting.
Feedback regulation control device 13 comprises an electric control structure, is mainly used in controlling telescope systemSystem, receiving, the detected cornea 14 that test point provides apart from dynamic monitoring system 12 is anti-to convex surfacePenetrate after the distance of mirror 8, can change by adjusting electro-motor the position of convex reflecting mirror 8, realNow control to adjust the distance between concave mirror 9 and convex reflecting mirror 8, dynamically ensure that laser is poly-Burnt on detected cornea 14.
Filter system is mainly used in plasma optical signal and carries out noise reduction process. Concrete, system filtersTurnkey is drawn together optical filtering; Optical filtering surface is provided with highly reflecting films. More specifically, surface is provided with high anti-The optical filtering of penetrating film comprises the lens 7 with light-filtering characteristic and the dichroic mirror 10 with light-filtering characteristic. ToolThe lens 7 that have light-filtering characteristic are to obtain by highly reflecting films being set at lens surface, can be for otherThe optical signal that is different from the plasma light signal in band of cornea 14 carries out quantitative absorption, in passing throughThe stability of the plasma light spectrum signal of echelle spectrograph 4 and strong and weak contrast are effectively controlledSystem, thus signal to noise ratio improved. The dichroic mirror 10 with light-filtering characteristic is by mirror surface settingHighly reflecting films obtain, and can carry out noise reduction process by plasma optical signal.
Preferred embodiment, the reflectivity of the highly reflecting films that adopt is not less than 99.99%. High anti-Penetrating film specifically can be laser beam is carried out to height reflection, reflectivity 99.99%. Highly reflecting films can pass throughThe mode of electroplating is plated on optical filtering surface.
In addition, test point also comprises apart from dynamic monitoring system 12 monitor for focus focal position anti-Penetrate mirror 11, speculum 11 adopts the speculum that can allow plasma optical signal pass through.
The plasma optical signal that echelle spectrometer 4 in equipment is mainly used in gathering carries outSpectrum analysis, can buy acquisition from the market. Integration postpone 5 of detection systems mainly for the treatment ofThe plasma optical signal gathering, obtains quantitative spectral information. Computer 6 is for controlling whole establishingEach standby system, comprises and controls whether bright dipping of laser instrument 1, when echelle spectrometer 4 entersRow spectra collection and data processing etc., specifically can adopt normally used PC etc.
In detailed description of the invention, the process while utilizing this equipment to carry out cornea measurement is:
A. laser instrument Emission Lasers, laser focuses to cornea place by described telescopic system, makes cornea tableFace forms plasma signal;
B., after described plasma signal is processed by described filter system, postponed to survey by described integrationSystem is processed the plasma optical signal gathering, then carries out spectrum by described echelle spectrometer and divideAnalyse;
C. judge the mechanical property of cornea by spectrum analysis result.
The Laser induced plasma spectroscopy analytical equipment of measuring for cornea that present embodiment providesAnd method, can accurately obtain fast again the bio-mechanical property of cornea, as pass through induced with laserThe intensity of plasma signal can judge that whether the bio-mechanical property of cornea is normal etc.; And to testedSurvey person requires lower, is a kind of novel cornea measurement device.
The Laser induced plasma spectroscopy analysis of measuring for cornea that adopts present embodiment to provideEquipment, the spectrogram that observation obtains as shown in Figure 2, can be found out from spectrogram, only to there being angleThe spectrum of element that membrane tissue has, does not have other materials, as operation in use lubricating fluid,In operation with optics of the direct close contact of cornea etc., the corresponding spectrum of element having. FillDivide explanation, adopt Apparatus and method for of the present invention, can pass through more accurately, easily gained spectrumThe intensity of signal obtains the biomechanical property parameter of cornea.
The above the specific embodiment of the present invention, does not form limiting the scope of the present invention.Various other corresponding changes and distortion that any technical conceive according to the present invention has been done, all should wrapBe contained in the protection domain of the claims in the present invention.
Claims (10)
1. a Laser induced plasma spectroscopy analytical equipment of measuring for cornea, is characterized in that,Comprise: laser instrument, beam quality regulating system, light beam steering system, filter system, telescope systemSystem, test point is apart from dynamic monitoring system, feedback regulation control system, echelle spectrometer,Integration postpones detection system and computer;
Described beam quality regulating system is for controlling the output intensity of laser beam;
The described light beam steering system control laser beam that is used for turning back;
Described test point arrives the distance of telescopic system for detection of cornea apart from dynamic monitoring system;
Described feedback regulation control system is used for controlling telescopic system;
Described telescopic system, for regulating the focal position of laser, makes Laser Focusing to cornea,Anterior corneal surface forms plasma optical signal;
Described filter system carries out noise reduction process for plasma optical signal;
Described echelle spectrometer is for carrying out spectrum analysis to the plasma optical signal gathering;
Described integration postpones detection system for the treatment of the plasma optical signal gathering, and obtains quantitativeSpectral information.
2. Laser induced plasma spectroscopy analysis of measuring for cornea as claimed in claim 1 is establishedStandby, it is characterized in that, the optical maser wavelength of described laser instrument transmitting is 1064nm.
3. Laser induced plasma spectroscopy analysis of measuring for cornea as claimed in claim 1 is establishedStandby, it is characterized in that, the optical maser wavelength of described laser instrument transmitting is 266nm.
4. Laser induced plasma spectroscopy analysis of measuring for cornea as claimed in claim 1 is establishedStandby, it is characterized in that, described filter system comprises optical filtering; Described optical filtering surface is provided with high anti-Penetrate film.
5. Laser induced plasma spectroscopy analysis of measuring for cornea as claimed in claim 4 is establishedStandby, it is characterized in that, the reflectivity of described highly reflecting films is not less than 99.99%.
6. Laser induced plasma spectroscopy analysis of measuring for cornea as claimed in claim 4 is establishedStandby, it is characterized in that, the reflectivity of described highly reflecting films is 99.99%.
7. Laser induced plasma spectroscopy analysis of measuring for cornea as claimed in claim 4 is establishedStandby, it is characterized in that, described highly reflecting films are plated on described optical filtering surface by the mode of electroplating.
8. Laser induced plasma spectroscopy analysis of measuring for cornea as claimed in claim 1 is establishedStandby, it is characterized in that, described telescopic system comprises convex reflecting mirror and concave mirror, by adjustingSave the position that distance between described convex reflecting mirror and described concave mirror regulates Laser Focusing.
9. Laser induced plasma spectroscopy analysis of measuring for cornea as claimed in claim 1 is establishedStandby, it is characterized in that, described test point comprises single frequency laser interferometer, two apart from dynamic monitoring systemOne in frequency laser interferometer or laser range finder.
10. utilize the method that equipment carries out cornea measurement described in claim 1, it is characterized in that,Comprise:
A. laser instrument Emission Lasers, laser focuses to cornea place by described telescopic system, makes cornea tableFace forms plasma optical signal;
B., after described plasma optical signal is processed by described filter system, postponed to visit by described integrationExamining system is processed the plasma optical signal gathering, then carries out spectrum by described echelle spectrometerAnalyze;
C. judge the mechanical property of cornea by spectrum analysis result.
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| CN201510262847.1A CN104856640B (en) | 2015-05-21 | 2015-05-21 | Laser induced plasma spectroscopy analytical equipment and the method measured for cornea |
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| CN104856640B true CN104856640B (en) | 2016-05-25 |
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| CN108072634A (en) * | 2016-11-15 | 2018-05-25 | 中国科学院光电研究院 | It is a kind of to survey child's hair to obtain the Laser induced plasma spectroscopy analytical equipment of micro- information |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6592574B1 (en) * | 1999-07-28 | 2003-07-15 | Visx, Incorporated | Hydration and topography tissue measurements for laser sculpting |
| CN1433287A (en) * | 1999-12-23 | 2003-07-30 | 维思克斯公司 | Optical feedback system for vision correction |
| CN102046067A (en) * | 2008-03-27 | 2011-05-04 | 多汉尼眼科研究所 | Optical coherence tomography device, method, and system |
| US8215774B2 (en) * | 2009-04-01 | 2012-07-10 | Tearscience, Inc. | Ocular surface interferometry (OSI) devices and systems for imaging and measuring ocular tear film layer thickness(es) |
| CN103025283A (en) * | 2010-06-24 | 2013-04-03 | 爱尔康手术激光股份有限公司 | Method to guide a cataract procedure by corneal imaging |
| CN104382689A (en) * | 2014-12-02 | 2015-03-04 | 中国科学院光电研究院 | Femtosecond laser system using for imaging and operation at the same time |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2840256C (en) * | 2011-06-23 | 2021-11-09 | Amo Development, Llc | Ophthalmic range finding |
| WO2014094853A1 (en) * | 2012-12-20 | 2014-06-26 | Wavelight Gmbh | Apparatus, interface unit, suction ring and method to monitor corneal tissue |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6592574B1 (en) * | 1999-07-28 | 2003-07-15 | Visx, Incorporated | Hydration and topography tissue measurements for laser sculpting |
| CN1433287A (en) * | 1999-12-23 | 2003-07-30 | 维思克斯公司 | Optical feedback system for vision correction |
| CN102046067A (en) * | 2008-03-27 | 2011-05-04 | 多汉尼眼科研究所 | Optical coherence tomography device, method, and system |
| US8215774B2 (en) * | 2009-04-01 | 2012-07-10 | Tearscience, Inc. | Ocular surface interferometry (OSI) devices and systems for imaging and measuring ocular tear film layer thickness(es) |
| CN103025283A (en) * | 2010-06-24 | 2013-04-03 | 爱尔康手术激光股份有限公司 | Method to guide a cataract procedure by corneal imaging |
| CN104382689A (en) * | 2014-12-02 | 2015-03-04 | 中国科学院光电研究院 | Femtosecond laser system using for imaging and operation at the same time |
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