CN104840501A - Preparation method for total flavonoids of chrysanthemum - Google Patents
Preparation method for total flavonoids of chrysanthemum Download PDFInfo
- Publication number
- CN104840501A CN104840501A CN201510261737.3A CN201510261737A CN104840501A CN 104840501 A CN104840501 A CN 104840501A CN 201510261737 A CN201510261737 A CN 201510261737A CN 104840501 A CN104840501 A CN 104840501A
- Authority
- CN
- China
- Prior art keywords
- solution
- flos chrysanthemi
- extraction
- pressure
- obtains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000005986 Chrysanthemum x morifolium Nutrition 0.000 title claims abstract description 39
- 235000007516 Chrysanthemum Nutrition 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 229930003935 flavonoids Natural products 0.000 title abstract description 6
- 150000002215 flavonoids Chemical class 0.000 title abstract description 6
- 235000017173 flavonoids Nutrition 0.000 title abstract 4
- 240000007646 Chrysanthemum x morifolium Species 0.000 title description 2
- 229930003944 flavones Natural products 0.000 claims abstract description 38
- 235000011949 flavones Nutrition 0.000 claims abstract description 38
- 241000723353 Chrysanthemum Species 0.000 claims abstract description 37
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N flavone Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300.0' height='300.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 176.8,194.2 L 190.3,192.5' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 190.3,192.5 L 203.8,190.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-10 atom-0' d='M 137.4,162.8 L 145.2,173.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-10 atom-0' d='M 145.2,173.1 L 153.0,183.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 203.8,190.8 L 228.9,224.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 214.2,190.8 L 231.8,214.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-6 atom-1' d='M 220.0,152.5 L 203.8,190.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 228.9,224.0 L 270.2,218.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 270.2,218.8 L 286.4,180.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 265.0,209.8 L 276.3,183.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 286.4,180.5 L 261.2,147.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 261.2,147.3 L 220.0,152.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 256.1,156.4 L 227.2,160.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 220.0,152.5 L 194.9,119.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 198.7,121.0 L 203.2,110.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 203.2,110.3 L 207.7,99.7' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 191.0,117.7 L 195.5,107.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 195.5,107.1 L 200.0,96.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-7 atom-9' d='M 194.9,119.3 L 153.6,124.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 153.6,124.5 L 137.4,162.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 158.8,133.5 L 147.5,160.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 137.4,162.8 L 96.2,168.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 96.2,168.0 L 71.1,134.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 85.8,168.1 L 68.2,144.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-16 atom-11' d='M 80.0,206.3 L 96.2,168.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 71.1,134.9 L 29.8,140.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 29.8,140.0 L 13.6,178.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 35.0,149.0 L 23.7,175.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 13.6,178.4 L 38.8,211.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 38.8,211.5 L 80.0,206.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 43.9,202.5 L 72.8,198.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='157.6' y='204.3' class='atom-0' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='206.0' y='89.3' class='atom-8' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85.0' height='85.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 47.7,54.9 L 52.5,54.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 52.5,54.3 L 57.3,53.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-10 atom-0' d='M 38.4,45.8 L 41.2,49.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-10 atom-0' d='M 41.2,49.4 L 44.0,53.0' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 57.3,53.7 L 64.4,63.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 60.2,53.7 L 65.2,60.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-6 atom-1' d='M 61.8,42.8 L 57.3,53.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 64.4,63.1 L 76.1,61.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 76.1,61.6 L 80.6,50.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 74.6,59.1 L 77.8,51.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 80.6,50.7 L 73.5,41.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 73.5,41.4 L 61.8,42.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 72.1,43.9 L 63.9,44.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 61.8,42.8 L 54.7,33.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 55.8,33.9 L 57.4,30.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 57.4,30.1 L 59.0,26.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 53.6,33.0 L 55.2,29.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 55.2,29.2 L 56.8,25.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-7 atom-9' d='M 54.7,33.4 L 43.0,34.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 43.0,34.9 L 38.4,45.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 44.5,37.4 L 41.3,45.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 38.4,45.8 L 26.7,47.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 26.7,47.2 L 19.6,37.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 23.8,47.2 L 18.8,40.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-16 atom-11' d='M 22.2,58.1 L 26.7,47.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 19.6,37.8 L 7.9,39.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 7.9,39.3 L 3.4,50.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 9.4,41.8 L 6.2,49.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-14 atom-15' d='M 3.4,50.1 L 10.5,59.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 10.5,59.5 L 22.2,58.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-15 atom-16' d='M 11.9,57.0 L 20.1,56.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='43.8' y='58.1' class='atom-0' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='57.5' y='25.6' class='atom-8' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims abstract description 35
- 238000000605 extraction Methods 0.000 claims abstract description 28
- 239000002904 solvent Substances 0.000 claims abstract description 18
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 15
- 241000628997 Flos Species 0.000 claims description 48
- 238000001914 filtration Methods 0.000 claims description 34
- 239000000706 filtrate Substances 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 230000001476 alcoholic Effects 0.000 claims description 17
- 238000001035 drying Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229940106157 CELLULASE Drugs 0.000 claims description 14
- 108010059892 Cellulase Proteins 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- 238000005292 vacuum distillation Methods 0.000 claims description 8
- 238000007792 addition Methods 0.000 claims description 7
- 238000002604 ultrasonography Methods 0.000 claims description 7
- 238000009776 industrial production Methods 0.000 abstract description 2
- 238000009210 therapy by ultrasound Methods 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000001125 extrusion Methods 0.000 abstract 1
- 239000012466 permeate Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 description 12
- 239000003814 drug Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound data:image/svg+xml;base64,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 data:image/svg+xml;base64,PD94bWwgdmVyc2lvbj0nMS4wJyBlbmNvZGluZz0naXNvLTg4NTktMSc/Pgo8c3ZnIHZlcnNpb249JzEuMScgYmFzZVByb2ZpbGU9J2Z1bGwnCiAgICAgICAgICAgICAgeG1sbnM9J2h0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnJwogICAgICAgICAgICAgICAgICAgICAgeG1sbnM6cmRraXQ9J2h0dHA6Ly93d3cucmRraXQub3JnL3htbCcKICAgICAgICAgICAgICAgICAgICAgIHhtbG5zOnhsaW5rPSdodHRwOi8vd3d3LnczLm9yZy8xOTk5L3hsaW5rJwogICAgICAgICAgICAgICAgICB4bWw6c3BhY2U9J3ByZXNlcnZlJwp3aWR0aD0nODVweCcgaGVpZ2h0PSc4NXB4JyB2aWV3Qm94PScwIDAgODUgODUnPgo8IS0tIEVORCBPRiBIRUFERVIgLS0+CjxyZWN0IHN0eWxlPSdvcGFjaXR5OjEuMDtmaWxsOiNGRkZGRkY7c3Ryb2tlOm5vbmUnIHdpZHRoPSc4NS4wJyBoZWlnaHQ9Jzg1LjAnIHg9JzAuMCcgeT0nMC4wJz4gPC9yZWN0Pgo8cGF0aCBjbGFzcz0nYm9uZC0wIGF0b20tMCBhdG9tLTEnIGQ9J00gMy40LDQ1LjMgTCAyMi43LDM0LjInIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiMzQjQxNDM7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+CjxwYXRoIGNsYXNzPSdib25kLTEgYXRvbS0xIGF0b20tMicgZD0nTSAyMi43LDM0LjIgTCAzMC43LDM4LjgnIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiMzQjQxNDM7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+CjxwYXRoIGNsYXNzPSdib25kLTEgYXRvbS0xIGF0b20tMicgZD0nTSAzMC43LDM4LjggTCAzOC44LDQzLjUnIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiNFODQyMzU7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+CjxwYXRoIGNsYXNzPSdib25kLTIgYXRvbS0yIGF0b20tMycgZD0nTSA0NS4yLDQzLjUgTCA1My4zLDM4LjgnIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiNFODQyMzU7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+CjxwYXRoIGNsYXNzPSdib25kLTIgYXRvbS0yIGF0b20tMycgZD0nTSA1My4zLDM4LjggTCA2MS4zLDM0LjInIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiMzQjQxNDM7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+CjxwYXRoIGNsYXNzPSdib25kLTMgYXRvbS0zIGF0b20tNCcgZD0nTSA2MS4zLDM0LjIgTCA4MC42LDQ1LjMnIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiMzQjQxNDM7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+Cjx0ZXh0IHg9JzM5LjMnIHk9JzQ5LjgnIGNsYXNzPSdhdG9tLTInIHN0eWxlPSdmb250LXNpemU6OHB4O2ZvbnQtc3R5bGU6bm9ybWFsO2ZvbnQtd2VpZ2h0Om5vcm1hbDtmaWxsLW9wYWNpdHk6MTtzdHJva2U6bm9uZTtmb250LWZhbWlseTpzYW5zLXNlcmlmO3RleHQtYW5jaG9yOnN0YXJ0O2ZpbGw6I0U4NDIzNScgPk88L3RleHQ+Cjwvc3ZnPgo= CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 238000007654 immersion Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229940088598 Enzyme Drugs 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 238000007803 cold maceration Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- -1 flavone compound Chemical class 0.000 description 2
- 150000002213 flavones Chemical class 0.000 description 2
- 235000021285 flavonoid Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 206010003211 Arteriosclerosis coronary artery Diseases 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 241000131317 Capitulum Species 0.000 description 1
- 102000003914 Cholinesterases Human genes 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 208000004981 Coronary Disease Diseases 0.000 description 1
- 210000004351 Coronary Vessels Anatomy 0.000 description 1
- 208000002173 Dizziness Diseases 0.000 description 1
- 210000000232 Gallbladder Anatomy 0.000 description 1
- 206010019233 Headache Diseases 0.000 description 1
- 206010062060 Hyperlipidaemia Diseases 0.000 description 1
- 210000004185 Liver Anatomy 0.000 description 1
- 231100000614 Poison Toxicity 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010040943 Skin ulcer Diseases 0.000 description 1
- 108060008260 TIFA Proteins 0.000 description 1
- 230000003712 anti-aging Effects 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 230000003110 anti-inflammatory Effects 0.000 description 1
- 230000000840 anti-viral Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 201000008739 coronary artery disease Diseases 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000021271 drinking Nutrition 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000004634 feeding behavior Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000003285 pharmacodynamic Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000002390 rotary evaporation Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 230000002522 swelling Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Abstract
The invention relates to a preparation method for total flavonoids of chrysanthemum. By the combination of ultrahigh pressure extraction and ultrasonic extraction, the extraction sufficiency is ensured; after the chrysanthemum is subjected to ultrahigh pressure treatment and ultrasonic treatment, cells of the chrysanthemum are broken due to the collapse of cavitation bubbles instantaneously generated in a solvent under special actions such as an ultrahigh pressure extrusion action and ultrasonic cavitation and crushing actions, so that the solvent permeates into the cells, flavone components in the cells are dissolved in the solvent to accelerate mutual permeation and dissolution. Compared with a common extraction method, the preparation method for the total flavonoids of the chrysanthemum has the advantages that the yield of the total flavonoids is greatly improved, the extraction time is shortened, and the industrial production efficiency is improved.
Description
Technical field
The invention belongs to food, health food and the field of Chinese medicines, relate to a kind of preparation method of chrysanthemum total flavone.
Background technology
Flos Chrysanthemi (
chrysanthemum morifolium Ramat), being the perennial root herbaceous plant of Compositae, Chrysanthemum in Plant Taxonomy, in China's plantation extensively, drinking with a long history, is that excellent representative plant of holding concurrently eaten by medicine.China's Flos Chrysanthemi mainly contains 8 kinds, is respectively Flos Chrysanthemi, milli chrysanthemum, Chen Ju, Flos Chrysanthemi, Flos Chrysanthemi, Flos Chrysanthemi, Flos Chrysanthemi, Herba Tagetis Patulae.Flos Chrysanthemi is conventional Chinese medicine, be used as medicine with flower, conventional part is the dry capitulum of feverfew Flos Chrysanthemi, nature and flavor sweetness and bitterness, cool, there is effect of dispelling wind improving eyesight, heat-clearing and toxic substances removing, the cool gallbladder of suppressing the hyperactive liver, the disease such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, treatment skin ulcer, toxic swelling.Modern pharmacological research shows, the principle active component of Flos Chrysanthemi is flavone compound, triterpenoid compound and volatilization wet goods, chrysanthemum total flavone is the main pharmacodynamics active component of Flos Chrysanthemi, to cardiovascular system, there is good action, there is the multiple physiologically actives such as the effect of suppression cholinesterase, clinical trial shows that it has blood pressure lowering, coronary artery dilator, prevents coronary atherosclerosis, treatment coronary heart disease, reduces blood pressure, prevents hyperlipidemia, antibacterial, antiviral, antiinflammatory, anti-ageing multiple effect of waiting for a long time.
The traditional extraction technique of chrysanthemum total flavone comprises cold-maceration, Suo Tifa, circumfluence method, ultrasonic method etc., from Extraction solvent, conventional Extraction solvent comprises methanol, ethanol, acetone, petroleum ether etc., such as certain patent of invention 2013104510XX.X discloses a kind of extracting method of chrysanthemum total flavone, it crosses 20 mesh sieves after being pulverized by Flos Chrysanthemi, add petroleum ether mix homogeneously, through filter paper filtering after abundant decolouring, getting filtering residue volatilizes for subsequent use, accurately take the good material of pretreatment again, the alcoholic solution of 40-70% is added by solid-liquid ratio (g/mL) 1: 10-30, fully shake up rear immersion 1 hour, under temperature 20-50 0C, supersonic frequency 40KHz extracts 20-35min, obtain the total yellow intoxicated extract of Flos Chrysanthemi.But there is the problem extracting the low or organic solvent residual of organic efficiency in conventional extracting method, ultimately limit the application of chrysanthemum total flavone extract.The present invention is studied chrysanthemum total flavone extraction process, ites is desirable to obtain optimum extraction process.
Summary of the invention
In order to solve Problems existing in the preparation of existing chrysanthemum total flavone, the present invention aims to provide a kind of preparation method of chrysanthemum total flavone, it does not need to adopt harmful, easily residual organic solvent still can obtain very high extraction efficiency, meet the development trend of modern pharmaceutical technique, the health also meeting people is pursued.
A preparation method for chrysanthemum total flavone, is characterized in that, comprises the steps:
Step one, pulverizes: drying in oven Flos Chrysanthemi being placed in 60 DEG C lower than 5%, is then ground into 20-25 object powder to moisture;
Step 2, supertension enzymolysis: the warm water of Flos Chrysanthemi powder with 40-45 DEG C is mixed according to the ratio of mass ratio 1:1.8-2.2, then add cellulase to mix thoroughly, be placed in high-pressure-resistant vessel, maintain the temperature at 40-45 DEG C, be forced into 15-20MPa, after maintaining 20-25min, pressure release obtains enzymolysis solution, and the consumption of its cellulase is 60-65U/g Flos Chrysanthemi;
Step 3, hyperpressure extraction: add the alcoholic solution that volumetric concentration is 85% in the enzymolysis solution of step 2, the addition of alcoholic solution is 2-2.5 times of Flos Chrysanthemi powder quality, mix rear continuation thoroughly and carry out ultra high pressure treatment in high-pressure-resistant vessel, maintenance temperature is 70-75 DEG C, pressure is 20-25MPa, HIGH PRESSURE TREATMENT 5-10min, filters after pressure release, be separated filtering residue and filtrate, filtrate is extracting solution A;
Step 4, ultrasound assisted extraction: the ethanol adding 75% of filtering residue quality 2 times in the filtering residue that step 3 obtains, carries out ultrasonic extraction, ultrasound condition is frequency 40kHz, temperature 62-65 DEG C, time 5-10min, supersound process terminates rear collecting by filtration filtrate, is extracting solution B;
Step 5, concentrated: the extracting solution B that extracting solution A step 3 obtained, step 4 obtain merges, and uses Rotary Evaporators vacuum distillation recovered solvent, obtains concentrated solution, be extractum.
Step 6, dry: put in baking oven by the extractum that step 5 is obtained and carry out cold drying, control temperature is 30-35 DEG C, is dried to water content lower than 5%, namely obtains chrysanthemum total flavone.
Method tool of the present invention has the following advantages and beneficial effect:
First, the present invention only selects alcoholic solution as Extraction solvent in the process extracting chrysanthemum total flavone, it is all reclaimed in follow-up rotary evaporation process, and it is as a kind of Extraction solvent of food stage, there is not residual and safety issue, meet the growth requirement of modern food and medicine trade.
The second, present invention employs supertension ferment treatment, in the process, by the pressure of supertension and the effect of enzyme, cellularity is sufficiently damaged before extraction, be conducive to the release of Flavonoid substances and fully carrying out of extraction.
3rd, the present invention adopts hyperpressure extraction and supersound extraction to combine, both combinations ensure that the adequacy of extraction, Flos Chrysanthemi is after supertension, ultrasonic Treatment, due to the special role such as squeezing action and hyperacoustic cavitation, pulverizing of supertension, make the cell of Flos Chrysanthemi in a solvent the cavitation bubble of instantaneous generation collapse and break, so that solvent penetration is to cell interior, thus make the flavone component in cell be dissolved among solvent, to accelerate to interpenetrate, dissolve.It compares common extracting method, and total flavones yield has had larger lifting, and extraction time also shortens, and improves industrial production efficiency.
In a word, the multiple advanced technology of methods combining of the present invention, production efficiency and the extraction ratio of chrysanthemum total flavone is drastically increased by the adjustment of processing step and the optimization of technological parameter, and obtained product also meets the growth requirement of modern food, health product and medicine trade, there is wide market prospect.
Detailed description of the invention
embodiment 1: a kind of preparation method of chrysanthemum total flavone, comprises the steps:
Step one, pulverizes: drying in oven Flos Chrysanthemi being placed in 60 DEG C lower than 5%, is then ground into 22 object powder to moisture;
Step 2, supertension enzymolysis: the warm water of Flos Chrysanthemi powder with 42 DEG C is mixed according to the ratio of mass ratio 1:1.9, then add cellulase to mix thoroughly, be placed in high-pressure-resistant vessel, maintain the temperature at 42 DEG C, be forced into 18MPa, after maintaining 22min, pressure release obtains enzymolysis solution, and the consumption of its cellulase is 63U/g Flos Chrysanthemi;
Step 3, hyperpressure extraction: add the alcoholic solution that volumetric concentration is 85% in the enzymolysis solution of step 2, the addition of alcoholic solution is 2 times of Flos Chrysanthemi powder quality, mix rear continuation thoroughly and carry out ultra high pressure treatment in high-pressure-resistant vessel, maintenance temperature is 70 DEG C, pressure is 22.5MPa, HIGH PRESSURE TREATMENT 8min, filters after pressure release, be separated filtering residue and filtrate, filtrate is extracting solution A;
Step 4, ultrasound assisted extraction: the ethanol adding 75% of filtering residue quality 2 times in the filtering residue that step 3 obtains, carries out ultrasonic extraction, ultrasound condition is frequency 40kHz, temperature 62 DEG C, time 5min, supersound process terminates rear collecting by filtration filtrate, is extracting solution B;
Step 5, concentrated: the extracting solution B that extracting solution A step 3 obtained, step 4 obtain merges, and uses Rotary Evaporators vacuum distillation recovered solvent, obtains concentrated solution, be extractum.
Step 6, dry: put in baking oven by the extractum that step 5 is obtained and carry out cold drying, control temperature is 32 DEG C, is dried to water content lower than 5%, namely obtains chrysanthemum total flavone.
embodiment 2: a kind of preparation method of chrysanthemum total flavone, comprises the steps:
Step one, pulverizes: drying in oven Flos Chrysanthemi being placed in 60 DEG C lower than 5%, is then ground into 25 object powder to moisture;
Step 2, supertension enzymolysis: the warm water of Flos Chrysanthemi powder with 40 DEG C is mixed according to the ratio of mass ratio 1:2.2, then add cellulase to mix thoroughly, be placed in high-pressure-resistant vessel, maintain the temperature at 40 DEG C, be forced into 20MPa, after maintaining 20min, pressure release obtains enzymolysis solution, and the consumption of its cellulase is 60U/g Flos Chrysanthemi;
Step 3, hyperpressure extraction: add the alcoholic solution that volumetric concentration is 85% in the enzymolysis solution of step 2, the addition of alcoholic solution is 2 times of Flos Chrysanthemi powder quality, mix rear continuation thoroughly and carry out ultra high pressure treatment in high-pressure-resistant vessel, maintenance temperature is 75 DEG C, pressure is 20MPa, HIGH PRESSURE TREATMENT 10min, filters after pressure release, be separated filtering residue and filtrate, filtrate is extracting solution A;
Step 4, ultrasound assisted extraction: the ethanol adding 75% of filtering residue quality 2 times in the filtering residue that step 3 obtains, carries out ultrasonic extraction, ultrasound condition is frequency 40kHz, temperature 65 DEG C, time 8min, supersound process terminates rear collecting by filtration filtrate, is extracting solution B;
Step 5, concentrated: the extracting solution B that extracting solution A step 3 obtained, step 4 obtain merges, and uses Rotary Evaporators vacuum distillation recovered solvent, obtains concentrated solution, be extractum.
Step 6, dry: put in baking oven by the extractum that step 5 is obtained and carry out cold drying, control temperature is 35 DEG C, is dried to water content lower than 5%, namely obtains chrysanthemum total flavone.
embodiment 3: a kind of preparation method of chrysanthemum total flavone, comprises the steps:
Step one, pulverizes: drying in oven Flos Chrysanthemi being placed in 60 DEG C lower than 5%, is then ground into 20 object powder to moisture;
Step 2, supertension enzymolysis: the warm water of Flos Chrysanthemi powder with 45 DEG C is mixed according to the ratio of mass ratio 1:1.8, then add cellulase to mix thoroughly, be placed in high-pressure-resistant vessel, maintain the temperature at 45 DEG C, be forced into 15MPa, after maintaining 25min, pressure release obtains enzymolysis solution, and the consumption of its cellulase is 65U/g Flos Chrysanthemi;
Step 3, hyperpressure extraction: add the alcoholic solution that volumetric concentration is 85% in the enzymolysis solution of step 2, the addition of alcoholic solution is 2.5 times of Flos Chrysanthemi powder quality, mix rear continuation thoroughly and carry out ultra high pressure treatment in high-pressure-resistant vessel, maintenance temperature is 72 DEG C, pressure is 20MPa, HIGH PRESSURE TREATMENT 10min, filters after pressure release, be separated filtering residue and filtrate, filtrate is extracting solution A;
Step 4, ultrasound assisted extraction: the ethanol adding 75% of filtering residue quality 2 times in the filtering residue that step 3 obtains, carries out ultrasonic extraction, ultrasound condition is frequency 40kHz, temperature 62 DEG C, time 10min, supersound process terminates rear collecting by filtration filtrate, is extracting solution B;
Step 5, concentrated: the extracting solution B that extracting solution A step 3 obtained, step 4 obtain merges, and uses Rotary Evaporators vacuum distillation recovered solvent, obtains concentrated solution, be extractum.
Step 6, dry: put in baking oven by the extractum that step 5 is obtained and carry out cold drying, control temperature is 35 DEG C, is dried to water content lower than 5%, namely obtains chrysanthemum total flavone.
embodiment 4: with comparing of traditional method
comparative example 1: certain method described in patent of invention 2013104510XX.X embodiment 1; namely Flos Chrysanthemi herb crosses 20 mesh sieves after pulverizing; add oil by solid-liquid ratio (g/mL) 1:8 to wake up mix homogeneously; after abundant decolouring; through filter paper sucking filtration, filtering residue adds solid-liquid ratio (g/mL) 1: 8 again and adds oil enzyme mix homogeneously, fully after decolouring; through filter paper sucking filtration, get filtering residue and volatilize for subsequent use; The material that accurately competent pretreatment is good, adds the alcoholic solution of 70%, fully shakes up rear immersion 1 hour, at temperature 20 0C, extract 30min under supersonic frequency 40KHz, obtain chrysanthemum total flavone extract by solid-liquid ratio (g/mL) 1 15.Put in baking oven again and carry out cold drying, control temperature is 32 DEG C, is dried to water content lower than 5%.
comparative example 2: traditional cold-maceration: take Flos Chrysanthemi part 100g, use 2000ml 70%(V/V respectively) ethanol, 95%(V/V) ethanol, methanol soak, after 24h, immersion is filtered, collect filtrate, use Rotary Evaporators vacuum distillation recovered solvent, obtain concentrated solution, the extractum namely extracted.Cream liquid puts oven drying at low temperature in baking oven, and weigh (put in baking oven and carry out cold drying, control temperature is 32 DEG C, is dried to water content lower than 5%).
With 100g Flos Chrysanthemi for test material, compare the output of the extractive of general flavone of embodiment 1,2,3 and comparative example 1,2 and recorded the purity of each extract ZHONGJUHUA total flavones by HPLC method, concrete outcome is: embodiment 1 obtains Flos Chrysanthemi flavone extract 4.79g, and purity is 65.2%; It is 4.91g that embodiment 2 obtains chrysanthemum total flavone extract, and purity is 62.1%; It is 4.56g that embodiment 3 obtains chrysanthemum total flavone extract, and purity is 69.3%; Comparative example 1 obtains chrysanthemum total flavone 3.24g, and purity is 43.5%; Comparative example 2 obtains chrysanthemum total flavone extract 2.07g, and purity is 45.1%.From above result of the test relatively, method of the present invention is combined by supertension enzymolysis and supersound extraction and drastically increases the yield of chrysanthemum total flavone extraction and the purity of extract, it can make limited Flos Chrysanthemi raw material prepare more Flavonoid substances on the one hand, has saved production cost; The purity of its obtained extract is higher on the other hand, and follow-up purifying process more simply, is easily realized.
Claims (3)
1. a preparation method for chrysanthemum total flavone, is characterized in that, comprises the steps:
Step one, pulverizes: drying in oven Flos Chrysanthemi being placed in 60 DEG C lower than 5%, is then ground into 20-25 object powder to moisture;
Step 2, supertension enzymolysis: the warm water of Flos Chrysanthemi powder with 40-45 DEG C is mixed according to the ratio of mass ratio 1:1.8-2.2, then add cellulase to mix thoroughly, be placed in high-pressure-resistant vessel, maintain the temperature at 40-45 DEG C, be forced into 15-20MPa, after maintaining 20-25min, pressure release obtains enzymolysis solution, and the consumption of its cellulase is 60-65U/g Flos Chrysanthemi;
Step 3, hyperpressure extraction: add the alcoholic solution that volumetric concentration is 85% in the enzymolysis solution of step 2, the addition of alcoholic solution is 2-2.5 times of Flos Chrysanthemi powder quality, mix rear continuation thoroughly and carry out ultra high pressure treatment in high-pressure-resistant vessel, maintenance temperature is 70-75 DEG C, pressure is 20-25MPa, HIGH PRESSURE TREATMENT 5-10min, filters after pressure release, be separated filtering residue and filtrate, filtrate is extracting solution A;
Step 4, ultrasound assisted extraction: the ethanol adding 75% of filtering residue quality 2 times in the filtering residue that step 3 obtains, carries out ultrasonic extraction, ultrasound condition is frequency 40kHz, temperature 62-65 DEG C, time 5-10min, supersound process terminates rear collecting by filtration filtrate, is extracting solution B;
Step 5, concentrated: the extracting solution B that extracting solution A step 3 obtained, step 4 obtain merges, and uses Rotary Evaporators vacuum distillation recovered solvent, obtains concentrated solution, be extractum;
Step 6, dry: put in baking oven by the extractum that step 5 is obtained and carry out cold drying, control temperature is 30-35 DEG C, is dried to water content lower than 5%, namely obtains chrysanthemum total flavone.
2. the preparation method of chrysanthemum total flavone according to claim 1, is characterized in that, comprises the steps:
Step one, pulverizes: drying in oven Flos Chrysanthemi being placed in 60 DEG C lower than 5%, is then ground into 22 object powder to moisture;
Step 2, supertension enzymolysis: the warm water of Flos Chrysanthemi powder with 42 DEG C is mixed according to the ratio of mass ratio 1:1.9, then add cellulase to mix thoroughly, be placed in high-pressure-resistant vessel, maintain the temperature at 42 DEG C, be forced into 18MPa, after maintaining 22min, pressure release obtains enzymolysis solution, and the consumption of its cellulase is 63U/g Flos Chrysanthemi;
Step 3, hyperpressure extraction: add the alcoholic solution that volumetric concentration is 85% in the enzymolysis solution of step 2, the addition of alcoholic solution is 2 times of Flos Chrysanthemi powder quality, mix rear continuation thoroughly and carry out ultra high pressure treatment in high-pressure-resistant vessel, maintenance temperature is 70 DEG C, pressure is 22.5MPa, HIGH PRESSURE TREATMENT 8min, filters after pressure release, be separated filtering residue and filtrate, filtrate is extracting solution A;
Step 4, ultrasound assisted extraction: the ethanol adding 75% of filtering residue quality 2 times in the filtering residue that step 3 obtains, carries out ultrasonic extraction, ultrasound condition is frequency 40kHz, temperature 62 DEG C, time 5min, supersound process terminates rear collecting by filtration filtrate, is extracting solution B;
Step 5, concentrated: the extracting solution B that extracting solution A step 3 obtained, step 4 obtain merges, and uses Rotary Evaporators vacuum distillation recovered solvent, obtains concentrated solution, be extractum;
Step 6, dry: put in baking oven by the extractum that step 5 is obtained and carry out cold drying, control temperature is 32 DEG C, is dried to water content lower than 5%, namely obtains chrysanthemum total flavone.
3. the preparation method of chrysanthemum total flavone according to claim 1, is characterized in that, comprises the steps:
Step one, pulverizes: drying in oven Flos Chrysanthemi being placed in 60 DEG C lower than 5%, is then ground into 25 object powder to moisture;
Step 2, supertension enzymolysis: the warm water of Flos Chrysanthemi powder with 40 DEG C is mixed according to the ratio of mass ratio 1:2.2, then add cellulase to mix thoroughly, be placed in high-pressure-resistant vessel, maintain the temperature at 40 DEG C, be forced into 20MPa, after maintaining 20min, pressure release obtains enzymolysis solution, and the consumption of its cellulase is 60U/g Flos Chrysanthemi;
Step 3, hyperpressure extraction: add the alcoholic solution that volumetric concentration is 85% in the enzymolysis solution of step 2, the addition of alcoholic solution is 2 times of Flos Chrysanthemi powder quality, mix rear continuation thoroughly and carry out ultra high pressure treatment in high-pressure-resistant vessel, maintenance temperature is 75 DEG C, pressure is 20MPa, HIGH PRESSURE TREATMENT 10min, filters after pressure release, be separated filtering residue and filtrate, filtrate is extracting solution A;
Step 4, ultrasound assisted extraction: the ethanol adding 75% of filtering residue quality 2 times in the filtering residue that step 3 obtains, carries out ultrasonic extraction, ultrasound condition is frequency 40kHz, temperature 65 DEG C, time 8min, supersound process terminates rear collecting by filtration filtrate, is extracting solution B;
Step 5, concentrated: the extracting solution B that extracting solution A step 3 obtained, step 4 obtain merges, and uses Rotary Evaporators vacuum distillation recovered solvent, obtains concentrated solution, be extractum;
Step 6, dry: put in baking oven by the extractum that step 5 is obtained and carry out cold drying, control temperature is 35 DEG C, is dried to water content lower than 5%, namely obtains chrysanthemum total flavone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510261737.3A CN104840501B (en) | 2015-05-21 | 2015-05-21 | A kind of preparation method of chrysanthemum total flavone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510261737.3A CN104840501B (en) | 2015-05-21 | 2015-05-21 | A kind of preparation method of chrysanthemum total flavone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104840501A true CN104840501A (en) | 2015-08-19 |
| CN104840501B CN104840501B (en) | 2018-08-24 |
Family
ID=53840749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510261737.3A Active CN104840501B (en) | 2015-05-21 | 2015-05-21 | A kind of preparation method of chrysanthemum total flavone |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104840501B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105087201A (en) * | 2015-08-26 | 2015-11-25 | 甘肃省轻工研究院 | Method for manufacturing maca beer |
| CN105326876A (en) * | 2015-11-11 | 2016-02-17 | 南阳师范学院 | Method for extracting total flavonoids of chrysanthemum |
| CN106860502A (en) * | 2017-03-09 | 2017-06-20 | 桂林融通科技有限公司 | The preparation method of bitter melon seed flavones |
| CN107468738A (en) * | 2017-09-22 | 2017-12-15 | 安徽菊泰滁菊草本科技有限公司 | A kind of extracting method of chrysanthemum total flavone |
| CN108530432A (en) * | 2017-03-01 | 2018-09-14 | 南京泽朗生物科技有限公司 | A kind of preparation method of Puerarin |
| CN108684909A (en) * | 2018-06-28 | 2018-10-23 | 广西昭平县凝香翠茶厂 | Green tea super-pressure method for increasing aroma |
| CN110237143A (en) * | 2019-06-14 | 2019-09-17 | 铜仁职业技术学院 | A method of enzymatic hydrolysis auxiliary reflux extracts Chinese lizardtail flavone |
| CN112159316A (en) * | 2020-10-28 | 2021-01-01 | 深圳市萱嘉生物科技有限公司 | Method for extracting gingerol by using ultrahigh pressure combined ultrasonic technology |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130093371A (en) * | 2012-02-14 | 2013-08-22 | 대구가톨릭대학교산학협력단 | Novel preparation method of mulberry leaf extract for anti-hypertensive, anti-diabetic, and anti-aging and the product of the same |
| CN104479042A (en) * | 2014-12-19 | 2015-04-01 | 桂林市和胤祥新型材料有限公司 | Method for extracting laminarin from kelp |
| CN104547205A (en) * | 2014-12-11 | 2015-04-29 | 惠州学院 | Method for extracting lychee seedvflavonoids via ultrasonic wave |
-
2015
- 2015-05-21 CN CN201510261737.3A patent/CN104840501B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130093371A (en) * | 2012-02-14 | 2013-08-22 | 대구가톨릭대학교산학협력단 | Novel preparation method of mulberry leaf extract for anti-hypertensive, anti-diabetic, and anti-aging and the product of the same |
| CN104547205A (en) * | 2014-12-11 | 2015-04-29 | 惠州学院 | Method for extracting lychee seedvflavonoids via ultrasonic wave |
| CN104479042A (en) * | 2014-12-19 | 2015-04-01 | 桂林市和胤祥新型材料有限公司 | Method for extracting laminarin from kelp |
Non-Patent Citations (1)
| Title |
|---|
| 杨阳等: "药用菊花总黄酮提取方法的比较", 《淮海医医》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105087201A (en) * | 2015-08-26 | 2015-11-25 | 甘肃省轻工研究院 | Method for manufacturing maca beer |
| CN105326876A (en) * | 2015-11-11 | 2016-02-17 | 南阳师范学院 | Method for extracting total flavonoids of chrysanthemum |
| CN108530432A (en) * | 2017-03-01 | 2018-09-14 | 南京泽朗生物科技有限公司 | A kind of preparation method of Puerarin |
| CN106860502A (en) * | 2017-03-09 | 2017-06-20 | 桂林融通科技有限公司 | The preparation method of bitter melon seed flavones |
| CN107468738A (en) * | 2017-09-22 | 2017-12-15 | 安徽菊泰滁菊草本科技有限公司 | A kind of extracting method of chrysanthemum total flavone |
| CN108684909A (en) * | 2018-06-28 | 2018-10-23 | 广西昭平县凝香翠茶厂 | Green tea super-pressure method for increasing aroma |
| CN110237143A (en) * | 2019-06-14 | 2019-09-17 | 铜仁职业技术学院 | A method of enzymatic hydrolysis auxiliary reflux extracts Chinese lizardtail flavone |
| CN112159316A (en) * | 2020-10-28 | 2021-01-01 | 深圳市萱嘉生物科技有限公司 | Method for extracting gingerol by using ultrahigh pressure combined ultrasonic technology |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104840501B (en) | 2018-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104840501A (en) | Preparation method for total flavonoids of chrysanthemum | |
| CN102948758B (en) | Method for extracting buckwheat flavone from buckwheat bran | |
| CN102048885B (en) | Extraction process for lychee seed saponin | |
| CN101942355A (en) | Comprehensive extraction method for extracting tea seed oil, tea saponin and tea seed polysaccharide from tea seeds or camellia seeds | |
| CN106243172B (en) | A method of extracting black fruit fructus lycii anthocyanin | |
| CN104098641B (en) | A kind of method extracting mogroside V from Grosvenor Momordica | |
| CN104961839A (en) | Preparation method of specific pachyman formula granule | |
| CN104623095A (en) | Extraction method for FructusLycii active ingredient | |
| CN105367679A (en) | Green tea polysaccharide extraction method | |
| CN102304501A (en) | Complex enzyme preparation and application and method thereof for extracting plant polysaccharides by using same | |
| CN103202866A (en) | Method to remove residual pesticide procymidone from ginseng extract | |
| CN104940280A (en) | Method for extracting total flavones from radix puerariae employing enzyme preparation | |
| CN103463160A (en) | Preparation method of high-content total flavones of chrysanthemum | |
| CN109053665B (en) | Method for extracting dihydromyricetin from vine tea and application | |
| CN102579564B (en) | Preparing method of Tibetan capillaris effective part extractives | |
| CN101081243A (en) | Hyperfrequency waves preliminary treatment for extracting polyphenol from artichoke haulm | |
| CN102335224A (en) | Method for cellulase and ultrasonic wave assisted extraction of flavonoids in peanut hull | |
| CN103446246A (en) | Process for extracting effective ingredients from myrtle roots | |
| CN106565422A (en) | Extraction process for hydroxytyrosol from olive leaf | |
| CN104086615B (en) | A kind of method preparing mogroside V from Grosvenor Momordica | |
| CN108992473A (en) | A method of extracting ginko leaves flavone | |
| CN105154485A (en) | Method for extracting compound amino acid from polygonatum odoratum through enzymolysis and ultrasonic treatment | |
| CN103059093B (en) | Method for preparing saponin by vacuum digestion | |
| CN102091107B (en) | Method for extracting total triterpene of centella asiatica by enzymic process | |
| CN101962386A (en) | Process for extracting arteannuin by biological compound enzymes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180706 Address after: 712000 Xixian New District, Shaanxi, Xinzhou Zhuang village, Xinling village, Qin Han new town, No. 6, Changxin Industrial Park, east of Tiangong Road, 6 Applicant after: Shaanxi Ke Hong health industry Co., Ltd. Address before: 315042 No. 29, 39 lane, Zhongxing Road, Jiangdong District, Ningbo, Zhejiang province (7-38) Applicant before: Ningbo good taste Food Co., Ltd |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |