CN104839164B - A kind of bactericidal composition taking metrafenone as main component - Google Patents
A kind of bactericidal composition taking metrafenone as main component Download PDFInfo
- Publication number
- CN104839164B CN104839164B CN201510295219.3A CN201510295219A CN104839164B CN 104839164 B CN104839164 B CN 104839164B CN 201510295219 A CN201510295219 A CN 201510295219A CN 104839164 B CN104839164 B CN 104839164B
- Authority
- CN
- China
- Prior art keywords
- metrafenone
- bactericidal composition
- powdery mildew
- oxygen quinoline
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition, its active ingredient is metrafenone and the third oxygen quinoline, and both mass ratioes are 1: 100～100: 1. Said composition synergistic effect is obvious, and preventive effect is high, is suitable for preventing and treating the multiple diseases on cereal gourd, fruit and vegetable, is particularly suitable for preventing and treating powdery mildew.
Description
Technical field
The present invention relates to a kind of bactericidal composition, relate in particular to a kind of bactericidal composition taking metrafenone as main component andThe application of its control corps diseases, belongs to technical field of pesticide.
Background technology
Powdery mildew is the plant disease being caused by the Erysiphaceae in fungi (Erysiphacesae). Mostly be ectoparasitism,Whole or the large portion of mycelium is exposed to leaf, stem, the tender tip, bud, flower and the fruit real surface of host plant, and produces in a large number by myceliaThe macroscopic white powder that body, conidiophore and conidium form.
Powdery mildew is widely distributed in the whole world, and the dicotyledon of causing harm is particularly general. The main powdery mildew of China has by standing grainThe Cereal powdery mildew that powdery mildew (Ery-siphegraminis) causes; By Siberian cocklebur monofilament shell (SphaerothecaThe powdery mildew of the various plants such as melon, the beans that fuliginea) causes, crudefiber crop; By wheat snag shell (UncinulaNecator) wheat powdery mildew causing; The mulberry that caused by hazel ball pin shell (Phyllactiniacorylea), pears, persimmon, walnut,The powdery mildew of more than the 80 kind of trees such as chestnut, lichee, papaya; The rose being caused by rose monofilament shell (Sphaerothecapannosa)Common vetch belongs to the powdery mildew of flowers etc.
Cucurbits powdery mildew is the important disease in melon production. While just generation, blade produces yellow point, then expands and sends outGenerate circle or oval scab, the mould layer of the raw adularescent powdery in surface, is conidiophore and the conidium of germ, rear scabFlavescence brown is the cleistothecium of germ. Mildew is early stage disperses separately, after be unified into a large mildew, even can cover full leaf,Have a strong impact on photosynthesis, eubolism is interfered, cause early ageing, output incurs loss.
In the control of powdery mildew, mainly rely on the bactericide such as benzimidazole, triazole type. These medicaments are because make for a long timeWith having produced the resistance to the action of a drug in various degree, prevention effect reduces. Especially triazole type medicament in the time that using dosage is large to cropGrowth have inhibitory action, easily cause poisoning.
Metrafenone, english common name: metrafenone, is Benzophenones new type bactericide, molecular formula C19H21BrO5，Can effectively prevent and treat cereal, the powdery mildew of melon and fruit and vegetables. But the production that metrafenone is current and use cost are all higher, and longPhase, independent use also had very large resistance risk.
Summary of the invention
The object of this invention is to provide a kind of synergistic effect obvious, to powdery mildew prevention effect is good, cost is low, resistance riskLow bactericidal composition.
Another object of the present invention is to provide the application of this bactericidal composition.
Inventor is by a large amount of indoor biometrics and field control effectiveness test, surprisingly finds that metrafenone and the third oxygen quinoline are with necessarilyRatio mixture after, the diseases such as powdery mildew are had to significant synergistic effect.
Described the third oxygen quinoline: English name proquinazid, molecular formula C14H17IN2O2, effective to various powdery mildews.
The third oxygen quinoline is bactericide well known in the art, can obtain by various commercial channel.
For overcoming the deficiencies in the prior art, technical scheme of the present invention is to solve like this: a kind of bactericidal composition, containsActive ingredient metrafenone and the third oxygen quinoline, both mass ratioes are 1: 100～100: 1, preferred mass ratio is 1: 30～30: 1.
The active ingredient of said composition and auxiliary agent and filler can be processed into the upper any formulation allowing of agricultural, agent preferablyType has missible oil, microemulsion, aqueous emulsion, suspending agent, wettable powder, water dispersible granules.
In bactericidal composition of the present invention, the mass accumulation percentage composition of active ingredient is 5%～85%.
The formulation of above-mentioned bactericidal composition, except comprising active ingredient, also comprises that auxiliary agent and other contribute to drug effect performanceMaterial. Missible oil comprises organic solvent, cosolvent and emulsifying agent; Microemulsion comprises organic solvent, emulsifying agent and water; Aqueous emulsion bagDraw together organic solvent, dispersant, emulsifying agent and water; Suspending agent comprises water, dispersant, thickener, antifreezing agent and wetting agent; WettablePulvis comprises wetting agent, dispersant and filler; Water dispersible granules comprises dispersant, disintegrant, filler and wetting agent. Below be allIn pesticidal preparations, commonly use or allow the various compositions that use, being not particularly limited, concrete composition and consumption are logical according to formula requirementCrossing simple experiment determines. For example:
Organic solvent can select isopropyl alcohol, dimethylbenzene, DMF, ring ethyl ketone, toluene, dimethyl sulfoxide (DMSO),Methyl alcohol, ethanol, trimethyl cyclic ethylene ketone, NOP, 1-METHYLPYRROLIDONE, propyl alcohol, butanols, ethylene glycol, diethylOne or more in glycol, EGME, butyl ether, ethyl acetate, vegetable oil.
Cosolvent can be selected a kind of or many in 1-METHYLPYRROLIDONE, dimethyl formamide, ethanol, the third ethanol, acetoneKind.
Dispersant can be selected sodium lignin sulfonate, calcium lignosulfonate, pulls open powder, calcium dodecyl benzene sulfonate, polycarboxylic acidsSalt, alkyl benzene sulfonate calcium salt, APES, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, glycerin fattyOne or more in acid esters APEO.
Emulsifying agent can be selected agricultural emulsifier NO．600 (phenyl phenol polyoxy ethylether), agriculture breast, and No. 1601 (phenethyl phenol polyoxy ethyl is poly-Propenyl ether), agriculture breast No. 500 (alkyl benzene calcium sulfonates), OP series phosphates (NPE phosphate), No. 600Phosphate (phenyl phenol polyoxy ethylether phosphate), styrene polyoxyethylene rice ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salts,Triethanolamine salt, agriculture breast No. 400 (benzyl xylenol polyoxy ethylether), Nongru-700s number (alkyl phenolic resin polyoxy ethylether),Peaceful breast No. 36 (phenethyl fluosite polyoxy ethylether), agricultures newborn No. 1600 (phenethyl phenol polyoxy ethyl polypropylene-base ethers),Ethylene oxide-propylene oxide block copolymer, OP series (NPE), No. 33 (alkylaryl polyoxies third of agriculture breastAlkene APEO), agriculture breast No. 34 (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitol anhydride monostearatesEster), one in tween series (sorbitan fatty acid ester APEO), AEO series (fat alcohol alcohol APEO)Or multiple.
Antifreezing agent can be selected one or more in glycerine, urea, ethylene glycol, propane diols.
Wetting agent can be selected methyl naphthalene sulfonate formaldehyde condensate, lauryl sodium sulfate, Negel, alkylbenzeneSulfoacid calcium, tea are withered, spaonin powder, silkworm excrement, soapberry powder, bay alcohol radical sodium sulphate, washing powder, pull open one or more in powder.
Disintegrant can be selected the one in ammonium sulfate, urea, bentonite, aluminium chloride, citric acid, succinic acid, sodium acid carbonateOr multiple.
Thickener can select in xanthans, CMC, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol a kind of orMultiple.
Filler can be selected White Carbon black, ridge soil, precipitated calcium carbonate, talcum, imvite or convex-concave rod stone, float stone, brickbat, Hai PaoOne or more in stone or bentonite and non-adsorptivity calcium soil or sand.
Product described in the invention can finished product preparation form provide, and in composition, each material mixes, combinationThe composition of thing also can provide with single dose form, before use, directly in bucket or tank, directly mixes, and is then diluted to required denseDegree.
Bactericidal composition of the present invention can be used for the fungus-caused plant disease such as sac fungus, basidiomycetes, is particularly useful forPrevent and treat powdery mildew. Composition of the present invention can be used by common method, as cast, injection, spraying, dusting, distribution or send outCigarette, its amount of application is with weather condition or crop state variation.
Compared with prior art, its advantage is in the present invention: 1, composition synergistic effect is obvious, and preventive effect is remarkable compared with single doseImprove; 2, after drug effect improves, the effective ingredient consumption in field declines, and has reduced production and use cost, has reduced residues of pesticidesAnd environmental pollution; 3, composition is made up of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delayThe drug-fast generation of germ.
Detailed description of the invention
The pesticide active ingredient of different types of structure being carried out composite, is to solve at present cost in agricultural chemicals single dose application processA kind of effective means with problems such as resistances. The pesticide active ingredient of different types of structure shows three kinds of works after mixing conventionallyBy type, i.e. summation action, synergistic effect and antagonism, but be specially which kind of effect, and unpredictable, only have by a large amount of examinationsTest just and can know. Compound synergic is well filled a prescription, and can improve actual prevention effect, reduces the use amount of agricultural chemicals, contributes to delayThe generation of resistance is the important means of scientific prevention and cure disease and pest.
The present composition has obvious synergistic function to Powdery Mildew etc., and is not only two kinds of pharmacy effectsSimple addition, this can be clear that from result of following Toxicity Determination test very much.
Biologicall test embodiment: the Toxicity Determination test of composition to cucurbits powdery mildew bacterium
Subjects is wheat powdery mildew (Erysiphegraminis).
Test method: with reference to " the agricultural industry criteria NY/T1156.4-2006 of the People's Republic of China (PRC) ". Choose growing way oneThe potted plant three leaf one heart stage wheat seedlings that cause, 5 basins are selected in each processing, number for subsequent use. With Potter spray tower under 50PSI pressureSpraying, every basin 5mL. Test is processed referring to table 1, table 2, and each medicament arranges 5 concentration gradients. After 24h, tremble powder inoculation littleWheat powdery mildew bacterium conidium. Taking the wheat seedling that sprays equivalent clear water as blank. After inoculation, wheat seedling is put into greenhouseCultivate. After 7d, according to the morbidity grade scale investigation disease index of wheat powdery mildew, and calculate prevention effect.
Wheat powdery mildew severity Scaling standard:
0 grade: blade is without scab;
1 grade: lesion area accounts for below 5% of whole blade area;
3 grades: lesion area accounts for 6%～10% of whole blade area;
5 grades: lesion area accounts for 11%～25% of whole blade area;
7 grades: lesion area accounts for 25%～50% of whole blade area;
9 grades: lesion area accounts for the more than 50% of whole blade area.
The expection effect (being theoretical prevention effect, %) of mixture of active principles use Colby formula determine and with observationThe effect comparison of arriving:
Colby formula: E=X+Y-X*Y/100
E: when active components A working concentration in composition is a, compositions contemplated effect when active component B working concentration is bPower.
X: effect when active components A using dosage is a.
Y: effect when active component B using dosage is b.
In the time that exceeding expection preventive effect, the actual prevention effect of observing illustrates that mixture has synergistic effect.
Toxicity test result referring to table 1 to table 2.
The pot experiment measurement result of the independent reactive compound of table 1 to wheat powdery mildew
The composite pot experiment measurement result to wheat powdery mildew of table 2 metrafenone and the third oxygen quinoline
Result of the test shows, metrafenone and the third oxygen quinoline composite control wheat powdery mildew within the specific limits, has synergyEffect.
In order to make object of the present invention, technical scheme and advantage clearer, the present invention is real with following concrete preparationExample describes, but the present invention is limited to absolutely not these examples. The following stated is only the good embodiment of the present invention, only in order to separateRelease the present invention, can not therefore be interpreted as the restriction to the scope of the claims of the present invention. It should be pointed out that all in essence of the present inventionAny amendment of making within god and principle, be equal to replacement and improvement etc., within protection scope of the present invention all should be included in. CauseThis, the protection domain of patent of the present invention should be as the criterion with claims.
Missible oil embodiment
Pesticide activity component, emulsifying agent, partial solvent are mixed in proportion, and mix and blend in modulation kettle, treats completely moltenXie Hou, more remaining solvent is added lentamente, after fully stirring, obtain uniform oil phase, make missible oil product.
Embodiment 1,20.2% metrafenone the third oxygen quinoline missible oil
Metrafenone 20%, the third oxygen quinoline 0.2%, agriculture breast No. 500 2% (emulsifying agent), dimethylbenzene (solvent) are supplemented to100％。
Embodiment 2,15.5% metrafenone the third oxygen quinoline missible oil
Metrafenone 15%, the third oxygen quinoline 0.5%, agriculture breast No. 500 3% (emulsifying agent), dimethylbenzene (solvent) are supplemented to100％。
Microemulsion, aqueous emulsion embodiment
By each component proportion, solubilization of active ingredient, in solvent and cosolvent, is added to surfactant, mix systemObtain oil phase. Water-soluble component and water are mixed and makes water, then oil phase is added in water or water adds in oil phase, limit edgedStir, make microemulsion or aqueous emulsion.
Embodiment 3,5% metrafenone the third oxygen quinoline microemulsion
Metrafenone 2.5%, the third oxygen quinoline 2.5%, toluene 8% (solvent), agriculture breast No. 500 8% (emulsifying agent), agriculture breasts 600Number 5% (emulsifying agent), agriculture breast No. 1,600 5% (emulsifying agent), sldium lauryl sulfates 2% (wetting agent), ethylene glycol 5% are (antifreezeAgent), water is supplemented to 100%
Embodiment 4,15% metrafenone the third oxygen quinoline aqueous emulsion
Metrafenone 5%, the third oxygen quinoline 10%, DMF (solvent) 5%, cyclohexanol (solvent) 10%, glycerine (antifreezing agent) 5%,Phenethyl phenol polyethenoxy ether (emulsifying agent) 10%, calcium dodecyl benzene sulfonate (wetting agent) 5%, water are supplemented to 100%
Suspending agent embodiment
Each components such as active component, dispersant, defoamer, thickener and water are mixed in the ratio of formula, through sandAfter mill or high speed shear, obtain semi-finished product, after analysis, add water and mix filtration and obtain suspending agent. Embodiment 5,31% benzene bacteriumKetone the third oxygen quinoline suspending agent
Metrafenone 1%, the third oxygen quinoline 30%, NPE 8% (emulsifying agent), propane diols 2% (cosolvent),Xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%
Embodiment 6,30.3% metrafenone the third oxygen quinoline suspending agent
Metrafenone 0.3%, the third oxygen quinoline 30%, NPE 8% (emulsifying agent), propane diols 2% (hydrotropyAgent), xanthans 1% (thickener), organosilicon 2% (defoamer), water be supplemented to 100%
Water dispersible granules embodiment
Pesticide activity component, auxiliary agent and filler are mixed in proportion, through air-flow crushing, then add the water of 15-20%, through pinchingClose, granulation, dry, screening make water dispersible granules product. Capital equipment: mixer, airslide disintegrating mill, kneader, extruding are madeGrain machine, drying equipment (drying room or fluid bed).
Embodiment 7,85% metrafenone the third oxygen quinoline water dispersible granules
Metrafenone 50%, the third oxygen quinoline 35%, neopelex 4% (wetting agent), sodium lignin sulfonate 10%(dispersant), ammonium sulfate 3% (disintegrant), kaolin (filler) are to 100%
Wettable powder embodiment
Pesticide activity component, auxiliary agent, filler are mixed in proportion after air-flow crushing and mix and make wettable powder again. MainWant equipment: mixer, airslide disintegrating mill.
Embodiment 8,50% metrafenone the third oxygen quinoline wettable powder
Metrafenone 15%, the third oxygen quinoline 35%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dividePowder), white carbon 8% (filler), kaolin (filler) be to 100%
Embodiment 9,35% metrafenone the third oxygen quinoline wettable powder
Metrafenone 25%, the third oxygen quinoline 10%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dividePowder), white carbon 8% (filler), kaolin (filler) be to 100%
Field Application Example: metrafenone and the composite field control effectiveness test to wheat powdery mildew of the third oxygen quinoline
Xiangyang, test site Hubei. Test medicine and consumption are in table 3, and repeat 4 communities of every processing, each community area 20Square metre. Carry out dispenser for the first time at disease early period of origination, even spraying, till being sprayed onto blade and dripping, is treated to sky with clear waterWhite contrast. After 7 days, execute medicine for the second time. Before the medicine for the first time and for the second time incidence of 10 days investigation wheat powdery mildews after medicine.Every community adopts 5 samplings, every some investigation two strains, and all blades are investigated in every strain, account for the percentage of whole leaf area with lesion areaRate is carried out classification and is recorded. Calculate each processing disease index and prevention effect.
Grade scale:
0 grade: without scab;
1 grade: lesion area accounts for below 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for the more than 50% of whole leaf area.
Drug effect computational methods:
As can be seen from Table 3: metrafenone, the third oxygen quinoline single dose to the preventive effect of wheat powdery mildew be respectively 76.5%,75.6%, and embodiment of the present invention bactericidal composition is all significantly increased in preventive effect, minimum preventive effect is 85.6%, is up to91.6%. The result of field test fully shows, metrafenone and the third oxygen quinoline are composite to be had afterwards to wheat powdery mildew significantlySynergistic function, in the situation that effective ingredient consumption reduces compared with single dose, prevention effect significantly improves. Therefore, of the present invention groupCompound have reduce costs, the beneficial effect of delaying drug resistance, minimizing spraying times and residues of pesticides.
Table 3 metrafenone and the composite field test results to wheat powdery mildew of the third oxygen quinoline
Claims (5)
1. a bactericidal composition, is characterized in that: active ingredient is metrafenone and the third oxygen quinoline, and both mass ratioes are 1 ︰100～100︰1。
2. bactericidal composition according to claim 1, is characterized in that: the mass ratio of metrafenone and the third oxygen quinoline is 1 ︰ 30～30︰1。
3. bactericidal composition according to claim 1, is characterized in that: the mass accumulation percentage of active ingredient in compositionContent is 5%～85%.
4. according to the bactericidal composition described in claims 1 to 3 any one, it is characterized in that: formulation be missible oil, microemulsion,Aqueous emulsion, suspending agent, wettable powder or water dispersible granules.
5. the purposes of bactericidal composition claimed in claim 1 on control wheat powdery mildew.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510295219.3A CN104839164B (en) | 2015-05-28 | 2015-05-28 | A kind of bactericidal composition taking metrafenone as main component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510295219.3A CN104839164B (en) | 2015-05-28 | 2015-05-28 | A kind of bactericidal composition taking metrafenone as main component |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104839164A CN104839164A (en) | 2015-08-19 |
| CN104839164B true CN104839164B (en) | 2016-05-25 |
Family
ID=53839474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510295219.3A Active CN104839164B (en) | 2015-05-28 | 2015-05-28 | A kind of bactericidal composition taking metrafenone as main component |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104839164B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106172415B (en) * | 2016-07-22 | 2018-11-06 | 嘉兴尚云自动化设备有限公司 | A kind of composition pesticide of alkene containing benzo fluorine bacterium azoles and metrafenone |
| CN106172470A (en) * | 2016-07-26 | 2016-12-07 | 王瑞明 | A kind of bactericidal composition preventing and treating Oryza sativa L. powdery mildew |
| CN110476987A (en) * | 2019-08-28 | 2019-11-22 | 浙江海正化工股份有限公司 | Bactericidal pesticide composition and its preparation method and application containing copper 8-hydroxyquinolinate and metrafenone |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005104847A1 (en) * | 2004-04-30 | 2005-11-10 | Basf Aktiengesellschaft | Fungicidal mixtures |
| CN101677558A (en) * | 2007-04-25 | 2010-03-24 | 先正达参股股份有限公司 | fungicidal compositions |
-
2015
- 2015-05-28 CN CN201510295219.3A patent/CN104839164B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005104847A1 (en) * | 2004-04-30 | 2005-11-10 | Basf Aktiengesellschaft | Fungicidal mixtures |
| CN101677558A (en) * | 2007-04-25 | 2010-03-24 | 先正达参股股份有限公司 | fungicidal compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104839164A (en) | 2015-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101822255B (en) | Sterilization compound containing ZJ0712 | |
| CN104839164B (en) | A kind of bactericidal composition taking metrafenone as main component | |
| CN105309455A (en) | Sterilization composition with pyribencarb serving as main ingredient | |
| CN102246781A (en) | Bactericidal composite | |
| CN103858886A (en) | Sterilizing composition containing isopyrazam | |
| CN105265443A (en) | Bactericidal composition containing fluxapyroxad | |
| CN103125491B (en) | Sterilization composition containing fluazinam | |
| CN104054712B (en) | Sterilization composition containing boscalid | |
| CN103181393A (en) | Pesticide composition containing mandipropamid | |
| CN104855386A (en) | Sterilizing combination using metrafenone as main component | |
| CN102228035B (en) | Herbicide composition containing bispyribacsodium and oxaziclomefone | |
| CN101984818B (en) | Germicide composition | |
| CN103125485B (en) | Sterilization composition containing fenhexamid | |
| CN106665594A (en) | Sterilization composition containing flutianil | |
| CN103181389A (en) | Sterilizing combination | |
| CN101731238B (en) | Acibenzolar-containing sterilizing composition | |
| CN103181390B (en) | Pesticide composition containing diaryl ketone compound | |
| CN105309457A (en) | Sterilization composition with fenpyrazamine serving as main ingredient | |
| CN104798796A (en) | Bactericidal composition containing benzovindiflupyr and application thereof | |
| CN106614629A (en) | Sterilization composition including flutianil | |
| CN101755775B (en) | Bactericidal composite taking fluazinam as main ingredient | |
| CN104068033B (en) | Fungicidal composition containing boscalid | |
| CN102318605A (en) | Bactericidal composition | |
| CN106614628A (en) | Bactericidal composition | |
| CN107242239A (en) | A kind of composite bactericide containing probenazole and Isoprothiolane and its application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |