CN104839164A - Fungicide composition adopting metrafenone as main component - Google Patents
Fungicide composition adopting metrafenone as main component Download PDFInfo
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- CN104839164A CN104839164A CN201510295219.3A CN201510295219A CN104839164A CN 104839164 A CN104839164 A CN 104839164A CN 201510295219 A CN201510295219 A CN 201510295219A CN 104839164 A CN104839164 A CN 104839164A
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- metrafenone
- powdery mildew
- oxygen quinoline
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Abstract
The invention discloses a fungicide composition adopting metrafenone as a main component. The fungicide composition comprises effective components metrafenone and proquinazid at the mass ratio of (1:100) to (100:1). The composition is obvious in synergistic effect, high in control effect, suitable for prevention and treatment of various diseases on cereals, melons, fruits and vegetables and especially suitable for prevention and treatment of powdery mildew.
Description
Technical field
The present invention relates to a kind of bactericidal composition, particularly relating to a kind of take metrafenone as the bactericidal composition of main component and the application of control corps diseases thereof, belongs to technical field of pesticide.
Background technology
Powdery mildew is the plant disease caused by the Erysiphaceae (Erysiphacesae) in fungi.Mostly be ectoparasitism, the whole or large portion of mycelium is exposed to the leaf of host plant, stem, the tender tip, bud, flower and fruit real surface, and produces the macroscopic white powder thing be made up of mycelium, conidiophore and conidium in a large number.
Powdery mildew is widely distributed in the whole world, and dicotyledon of causing harm is particularly general.The main powdery mildew of China has the Cereal powdery mildew caused by standing grain powdery mildew (Ery-siphe graminis); The powdery mildew of the various plants such as melon, the beans caused by Siberian cocklebur monofilament shell (Sphaerotheca fuliginea), crudefiber crop; The wheat powdery mildew caused by wheat snag shell (Uncinula necator); The powdery mildew of more than the 80 kind of trees such as mulberry, pears, persimmon, walnut, chestnut, lichee, papaya papaw caused by hazel ball pin shell (Phyllactinia corylea); The powdery mildew etc. of the Flowers of Rosa caused by rose monofilament shell (Sphaerothecapannosa).
Cucurbits powdery mildew is the important disease in melon production.During first generation, blade produces yellow point, then expands and develops into circle or oval scab, and the mould layer of the raw adularescent powdery in surface, be conidiophore and the conidium of germ, rear scab flavescence brown is the cleistothecium of germ.Mildew is disperseed separately in early days, after be unified into a large mildew, even can cover full leaf, have a strong impact on photosynthesis, eubolism is interfered, causes early ageing, output incurs loss.
In the control of powdery mildew, mainly rely on the bactericide such as benzimidazole, triazole type.These medicaments are because Long-Time Service has created pesticide resistance in various degree, and control efficiency reduces.Especially triazole type medicament has inhibitory action when using dosage is large to the growth of crop, easily causes poisoning.
Metrafenone, english common name: metrafenone is Benzophenones new type bactericide, molecular formula C
19h
21brO
5, effectively can prevent and treat cereal, the powdery mildew of melon and fruit and vegetables.But the production that metrafenone is current and use cost all higher, and be used alone for a long time and also have very large resistance risk.
Summary of the invention
The object of this invention is to provide a kind of synergistic effect obvious, to the bactericidal composition that powdery mildew control efficiency is good, cost is low, resistance risk is low.
Another object of the present invention is to provide the application of this bactericidal composition.
Inventor by a large amount of indoor biometricses and field control effectiveness test, surprisingly finds metrafenone and the third oxygen quinoline in certain proportion after mixture, has significant synergistic effect to diseases such as powdery mildews.
Described third oxygen quinoline: English name proquinazid, molecular formula C
14h
17iN
2o
2, effective to various powdery mildew.
Third oxygen quinoline is bactericide well known in the art, can be obtained by various commercial channel.
For overcoming the deficiencies in the prior art, technical scheme of the present invention solves like this: a kind of bactericidal composition, containing active ingredient metrafenone and the third oxygen quinoline, both mass ratioes are 1: 100 ~ 100: 1, and preferred mass ratio is 1: 30 ~ 30: 1.
The active ingredient of said composition and auxiliary agent and filler can be processed into any formulation agriculturally allowed, and good formulation has missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder, water dispersible granules.
In bactericidal composition of the present invention, the mass accumulation percentage composition of active ingredient is 5% ~ 85%.
The formulation of above-mentioned bactericidal composition except comprising active ingredient, also comprise auxiliary agent and other contribute to drug effect play material.Missible oil comprises organic solvent, cosolvent and emulsifier; Microemulsion comprises organic solvent, emulsifier and water; Aqueous emulsion comprises organic solvent, dispersant, emulsifier and water; Suspending agent comprises water, dispersant, thickener, antifreezing agent and wetting agent; Wetting powder comprises wetting agent, dispersant and filler; Water dispersible granules comprises dispersant, disintegrant, filler and wetting agent.Below be all various compositions that are conventional in pesticidal preparations or permission use, be not particularly limited, concrete composition and consumption are determined by simple experiment according to recipe requirements.Such as:
Organic solvent can select in isopropyl alcohol, dimethylbenzene, DMF, ring ethyl ketone, toluene, dimethyl sulfoxide (DMSO), methyl alcohol, ethanol, trimethyl cyclic ethylene ketone, NOP, 1-METHYLPYRROLIDONE, propyl alcohol, butanols, ethylene glycol, diethylene glycol, ethylene glycol monomethyl ether, butyl ether, ethyl acetate, vegetable oil one or more.
Cosolvent can select in 1-METHYLPYRROLIDONE, dimethyl formamide, ethanol, the third ethanol, acetone one or more.
Dispersant can be selected sodium lignin sulfonate, calcium lignosulfonate, pulls open powder, one or more in calcium dodecyl benzene sulfonate, polycarboxylate, alkyl benzene sulfonate calcium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO.
Emulsifier can select agricultural emulsifier NO.600 (phenyl phenol polyoxyethyl ether), agriculture breast No. 1601 (phenethyl phenol polyoxyethanyl polypropylene-base ether), agriculture breast No. 500 (alkyl benzene calcium sulfonate), OP series phosphate (thermally coupled distillation columns), No. 600 phosphates (phenyl phenol polyoxyethanyl ether phosphate), styrene polyoxyethylene rice ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, agriculture breast No. 400 (benzyl xylenol polyoxyethyl ether), Nongru-700 number (alkyl phenolic resin polyoxyethyl ether), peaceful newborn No. 36 (phenethyl fluosite polyoxyethyl ether), agriculture breast No. 1600 (phenethyl phenol polyoxyethanyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), agriculture breast No. 33 (alkylaryl polyoxyethylene polyoxypropylene ether), agriculture breast No. 34 (alkylaryl polyoxyethylene poly-oxygen propylene aether), Span series (sorbitan monostearate), TWEEN Series (sorbitan fatty acid ester APEO), one or more in AEO series (fat alcohol alcohol APEO).
Antifreezing agent can select in glycerine, urea, ethylene glycol, propane diols one or more.
Wetting agent can select that methyl naphthalene sulfonate formaldehyde condensate, lauryl sodium sulfate, Negel, alkyl benzene calcium sulfonate, tea are withered, spaonin powder, silkworm excrement, soapberry powder, bay alcohol radical sodium sulphate, washing powder, pull open in powder one or more.
Disintegrant can select in ammonium sulfate, urea, bentonite, aluminium chloride, citric acid, succinic acid, sodium bicarbonate one or more.
Thickener can to select in xanthans, CMC, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol one or more.
Filler can select in White Carbon black, ridge soil, precipitated calcium carbonate, talcum, imvite or convex-concave rod stone, float stone, brickbat, sepiolite or bentonite and non-adsorbent calcium soil or sand one or more.
Product described in the invention can finished product preparation form provide, and namely in composition, each material mixes, and the composition of composition also can provide with unit dose form, directly directly mixes in bucket or tank, be then diluted to required concentration before using.
Bactericidal composition of the present invention can be used for the fungus-caused plant disease such as sac fungi, basidiomycetes, is particularly useful for preventing and treating powdery mildew.Composition of the present invention can be used by common method, as cast, injection, spraying, dusting, scatters or is fuming, and its amount of application is with weather condition or crop condition change.
Compared with prior art, its advantage is in the present invention: 1, composition synergistic effect is obvious, and preventive effect significantly improves compared with single dose; 2, after drug effect improves, the effective ingredient consumption in field declines, and reduces production and use cost, decreases residue of pesticide and environmental pollution; 3, composition is made up of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcoming and delay the drug-fast generation of germ.
Embodiment
Being undertaken composite by the pesticide active ingredient of different types of structure, is a kind of effective means solving the problem such as cost and resistance in agricultural chemicals single dose application process at present.After the pesticide active ingredient mixing of different types of structure, usually show three kinds of type of action, i.e. summation action, synergistic effect and antagonism, but be specially which kind of effect, unpredictable, only have and just can be known by lot of experiments.Compound synergic is well filled a prescription, and can improve actual control efficiency, and reduce the usage amount of agricultural chemicals, contributing to the generation of delaying drug resistance, is the important means of scientific prevention and cure damage by disease and insect.
The present composition has obvious synergistic function to Powdery Mildew etc., and is not only the simple addition of two kinds of pharmacy effects, is clear that very much this result can tested from following Toxicity Determination.
Assays Example: composition is tested the Toxicity Determination of cucurbits powdery mildew bacterium
Subjects is wheat powdery mildew (Erysiphe graminis).
Test method: with reference to " People's Republic of China (PRC) agricultural industry criteria NY/T 1156.4-2006 ".Choose the potted plant three leaf one heart stage wheat seedlings that growing way is consistent, 5 basins are selected in each process, number for subsequent use.Spray under 50PSI pressure with Potter spray tower, every basin 5mL.Test process is see table 1, table 2, and each medicament arranges 5 concentration gradients.Carry out after 24h trembling powder inoculation wheat powdery mildew conidium.To spray the wheat seedling of equivalent clear water for blank.After inoculation, wheat seedling is put into greenhouse to cultivate.After 7d, according to the morbidity grade scale investigation disease index of wheat powdery mildew, and calculate control efficiency.
Wheat powdery mildew severity Scaling standard:
0 grade: blade is without scab;
1 grade: lesion area accounts for less than 5% of whole blade area;
3 grades: lesion area accounts for 6% ~ 10% of whole blade area;
5 grades: lesion area accounts for 11% ~ 25% of whole blade area;
7 grades: lesion area accounts for 25% ~ 50% of whole blade area;
9 grades: lesion area accounts for more than 50% of whole blade area.
The expection effect (i.e. theoretical control efficiency, %) of mixture of active principles uses Colby formula to determine and compares with the effect observed:
Colby formula: E=X+Y-X*Y/100
E: when active components A working concentration in composition is a, compositions contemplated effect when active component B working concentration is b.
X: effect when active components A using dosage is a.
Effect when Y: active component B using dosage is b.
Illustrate that mixture has synergistic effect when the actual control efficiency observed exceedes expection preventive effect.
Toxicity test result see table 1 to table 2.
The independent reactive compound of table 1 is to the pot experiment measurement result of wheat powdery mildew
Table 2 metrafenone and the composite pot experiment measurement result to wheat powdery mildew of the third oxygen quinoline
Result of the test shows, metrafenone and the third oxygen quinoline composite control wheat powdery mildew within the specific limits, has synergistic effect.
In order to make object of the present invention, technical scheme and advantage clearly understand, the following concrete formulation examples of the present invention is described, but the present invention is limited to absolutely not these examples.The following stated is only the good embodiment of the present invention, only in order to explain the present invention, therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Missible oil embodiment
Pesticide activity component, emulsifier, partial solvent are mixed in proportion, mix and blend in modulation kettle, until completely dissolved, more remaining solvent is added lentamente, obtain uniform oil phase after fully stirring, make missible oil product.
Embodiment 1,20.2% metrafenone third oxygen quinoline missible oil
Metrafenone 20%, third oxygen quinoline 0.2%, agriculture breast No. 500 2% (emulsifier), dimethylbenzene (solvent) are supplemented to 100%.
Embodiment 2,15.5% metrafenone third oxygen quinoline missible oil
Metrafenone 15%, third oxygen quinoline 0.5%, agriculture breast No. 500 3% (emulsifier), dimethylbenzene (solvent) are supplemented to 100%.
Microemulsion, aqueous emulsion embodiment
By each component proportion, active component is dissolved in solvent and cosolvent, adds surfactant, mix obtained oil phase.By water-soluble component and the obtained aqueous phase of water mixing, then add in aqueous phase by oil phase or aqueous phase adds in oil phase, limit edged stirs, obtained microemulsion or aqueous emulsion.
Embodiment 3,5% metrafenone third oxygen quinoline microemulsion
Metrafenone 2.5%, third oxygen quinoline 2.5%, toluene 8% (solvent), agriculture breast No. 500 8% (emulsifier), agricultural emulsifier NO.600s 5% (emulsifier), agriculture breast No. 1,600 5% (emulsifier), sldium lauryl sulfate 2% (wetting agent), ethylene glycol 5% (antifreezing agent), water are supplemented to 100%
Embodiment 4,15% metrafenone third oxygen quinoline aqueous emulsion
Metrafenone 5%, third oxygen quinoline 10%, DMF (solvent) 5%, cyclohexanol (solvent) 10%, glycerine (antifreezing agent) 5%, phenethyl phenol polyethenoxy ether (emulsifier) 10%, calcium dodecyl benzene sulfonate (wetting agent) 5%, water are supplemented to 100%
Suspending agent embodiment
The ratio of each components such as active component, dispersant, defoamer, thickener and water in formula is mixed, after sand milling or high speed shear, obtains semi-finished product, add water after analysis and mix filtration and namely obtain suspending agent.Embodiment 5,31% metrafenone third oxygen quinoline suspending agent
Metrafenone 1%, third oxygen quinoline 30%, polyoxyethylene nonylphenol ether 8% (emulsifier), propane diols 2% (cosolvent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%
Embodiment 6,30.3% metrafenone third oxygen quinoline suspending agent
Metrafenone 0.3%, third oxygen quinoline 30%, polyoxyethylene nonylphenol ether 8% (emulsifier), propane diols 2% (cosolvent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%
Water dispersible granules embodiment
Pesticide activity component, auxiliary agent and filler are mixed in proportion, through air-flow crushing, then adds the water of 15-20%, obtain water dispersible granules product through kneading, granulation, drying, screening.Capital equipment: mixer, airslide disintegrating mill, kneader, Squeezinggranulator, drying equipment (drying room or fluid bed).
Embodiment 7,85% metrafenone third oxygen quinoline water dispersible granules
Metrafenone 50%, third oxygen quinoline 35%, neopelex 4% (wetting agent), sodium lignin sulfonate 10% (dispersant), ammonium sulfate 3% (disintegrant), kaolin (filler) are to 100%
Wetting powder embodiment
Pesticide activity component, auxiliary agent, filler are mixed in proportion after air-flow crushing, mixes obtained wetting powder again.Capital equipment: mixer, airslide disintegrating mill.
Embodiment 8,50% metrafenone third oxygen quinoline wetting powder
Metrafenone 15%, third oxygen quinoline 35%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dispersant), white carbon 8% (filler), kaolin (filler) are to 100%
Embodiment 9,35% metrafenone third oxygen quinoline wetting powder
Metrafenone 25%, third oxygen quinoline 10%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dispersant), white carbon 8% (filler), kaolin (filler) are to 100%
Field information embodiment: metrafenone and the composite field control effectiveness test to wheat powdery mildew of the third oxygen quinoline
Xiangyang, test site Hubei.Test medicine and consumption, in table 3, often process 4 communities and repeat, each plot area 20 square metres.Carry out first time dispenser at disease initial stage of origination, even spraying, be sprayed onto till blade drips, be treated to blank with clear water.Second time medicine is executed after 7 days.The incidence of 10 days investigation wheat powdery mildews before first time medicine and after second time medicine.Every community adopts 5 samplings, often some investigation two strains, and all blades are investigated in every strain, and the percentage accounting for whole leaf area with lesion area carrys out classification record.Calculate each process disease index and control efficiency.
Grade scale:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
Drug effect computational methods:
As can be seen from Table 3: metrafenone, the preventive effect of the third oxygen quinoline single dose to wheat powdery mildew are respectively 76.5%, 75.6%, and embodiment of the present invention bactericidal composition is all significantly increased in preventive effect, and minimum preventive effect is 85.6%, has been up to 91.6%.The result of field trial fully shows, metrafenone and the third oxygen quinoline is composite has significant synergistic function to wheat powdery mildew afterwards, and when effective ingredient consumption reduces compared with single dose, control efficiency significantly improves.Therefore, the present composition have reduce costs, the beneficial effect of delaying drug resistance, minimizing spraying times and residue of pesticide.
Table 3 metrafenone and the composite field test results to wheat powdery mildew of the third oxygen quinoline
Claims (5)
1. a bactericidal composition, is characterized in that: active ingredient is metrafenone and the third oxygen quinoline, and both mass ratioes are 1: 100 ~ 100: 1.
2. bactericidal composition according to claim 1, is characterized in that: the mass ratio of metrafenone and the third oxygen quinoline is 1: 30 ~ 30: 1.
3. bactericidal composition according to claim 1, is characterized in that: in composition, the mass accumulation percentage composition of active ingredient is 5% ~ 85%.
4. the bactericidal composition according to claims 1 to 3 any one, is characterized in that: formulation is missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder or water dispersible granules.
5. the purposes of bactericidal composition according to claim 1 on control crop powdery mildew.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106172415A (en) * | 2016-07-22 | 2016-12-07 | 李祥英 | A kind of containing benzo alkene fluorine bacterium azoles and the composition pesticide of metrafenone |
| CN106172470A (en) * | 2016-07-26 | 2016-12-07 | 王瑞明 | A kind of bactericidal composition preventing and treating Oryza sativa L. powdery mildew |
| CN110476987A (en) * | 2019-08-28 | 2019-11-22 | 浙江海正化工股份有限公司 | Bactericidal pesticide composition and its preparation method and application containing copper 8-hydroxyquinolinate and metrafenone |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005104847A1 (en) * | 2004-04-30 | 2005-11-10 | Basf Aktiengesellschaft | Fungicidal mixtures |
| CN101677558A (en) * | 2007-04-25 | 2010-03-24 | 先正达参股股份有限公司 | fungicidal compositions |
-
2015
- 2015-05-28 CN CN201510295219.3A patent/CN104839164B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005104847A1 (en) * | 2004-04-30 | 2005-11-10 | Basf Aktiengesellschaft | Fungicidal mixtures |
| CN101677558A (en) * | 2007-04-25 | 2010-03-24 | 先正达参股股份有限公司 | fungicidal compositions |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106172415A (en) * | 2016-07-22 | 2016-12-07 | 李祥英 | A kind of containing benzo alkene fluorine bacterium azoles and the composition pesticide of metrafenone |
| CN106172470A (en) * | 2016-07-26 | 2016-12-07 | 王瑞明 | A kind of bactericidal composition preventing and treating Oryza sativa L. powdery mildew |
| CN110476987A (en) * | 2019-08-28 | 2019-11-22 | 浙江海正化工股份有限公司 | Bactericidal pesticide composition and its preparation method and application containing copper 8-hydroxyquinolinate and metrafenone |
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