CN103125485B - Sterilization composition containing fenhexamid - Google Patents
Sterilization composition containing fenhexamid Download PDFInfo
- Publication number
- CN103125485B CN103125485B CN201110407146.4A CN201110407146A CN103125485B CN 103125485 B CN103125485 B CN 103125485B CN 201110407146 A CN201110407146 A CN 201110407146A CN 103125485 B CN103125485 B CN 103125485B
- Authority
- CN
- China
- Prior art keywords
- fenhexamid
- eugenol
- composition
- bactericidal composition
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 239000005776 Fenhexamid Substances 0.000 title claims abstract description 56
- VDLGAVXLJYLFDH-UHFFFAOYSA-N fenhexamid Chemical compound C=1C=C(O)C(Cl)=C(Cl)C=1NC(=O)C1(C)CCCCC1 VDLGAVXLJYLFDH-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 230000001954 sterilising effect Effects 0.000 title abstract 3
- 238000004659 sterilization and disinfection Methods 0.000 title abstract 3
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 102
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000005770 Eugenol Substances 0.000 claims abstract description 51
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 51
- 229960002217 eugenol Drugs 0.000 claims abstract description 51
- 235000012055 fruits and vegetables Nutrition 0.000 claims abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 13
- 239000000375 suspending agent Substances 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 10
- 238000009736 wetting Methods 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 7
- 239000004562 water dispersible granule Substances 0.000 claims description 7
- 239000012752 auxiliary agent Substances 0.000 claims description 5
- 238000009825 accumulation Methods 0.000 claims description 2
- 241000219122 Cucurbita Species 0.000 claims 1
- 235000009852 Cucurbita pepo Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 201000010099 disease Diseases 0.000 abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 10
- 239000000470 constituent Substances 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 241000219112 Cucumis Species 0.000 abstract description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 abstract description 2
- -1 NOP Chemical compound 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 238000009472 formulation Methods 0.000 description 17
- 240000008067 Cucumis sativus Species 0.000 description 14
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 14
- 239000000945 filler Substances 0.000 description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
- 239000000306 component Substances 0.000 description 11
- 239000002270 dispersing agent Substances 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 11
- 230000002195 synergetic effect Effects 0.000 description 11
- 239000000080 wetting agent Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 239000002562 thickening agent Substances 0.000 description 9
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 8
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 8
- 206010039509 Scab Diseases 0.000 description 7
- 210000000481 breast Anatomy 0.000 description 7
- 239000002131 composite material Substances 0.000 description 7
- 239000006184 cosolvent Substances 0.000 description 7
- 239000013530 defoamer Substances 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 7
- 229920001285 xanthan gum Polymers 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 230000003902 lesion Effects 0.000 description 6
- 239000000575 pesticide Substances 0.000 description 6
- 239000005995 Aluminium silicate Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 235000012211 aluminium silicate Nutrition 0.000 description 5
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 5
- 230000003449 preventive effect Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 4
- 241000123650 Botrytis cinerea Species 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 4
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 4
- 235000011130 ammonium sulphate Nutrition 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000007884 disintegrant Substances 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 description 4
- 235000011152 sodium sulphate Nutrition 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 239000003905 agrochemical Substances 0.000 description 3
- 150000004996 alkyl benzenes Chemical class 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000010534 mechanism of action Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000000361 pesticidal effect Effects 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- 239000008158 vegetable oil Substances 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
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- 239000003960 organic solvent Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 244000012254 Canarium album Species 0.000 description 1
- 235000009103 Canarium album Nutrition 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- GSNUFIFRDBKVIE-UHFFFAOYSA-N DMF Natural products CC1=CC=C(C)O1 GSNUFIFRDBKVIE-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 229920005682 EO-PO block copolymer Polymers 0.000 description 1
- 239000001293 FEMA 3089 Substances 0.000 description 1
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- 206010027146 Melanoderma Diseases 0.000 description 1
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- 208000031888 Mycoses Diseases 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
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- 241000221696 Sclerotinia sclerotiorum Species 0.000 description 1
- 239000004113 Sepiolite Substances 0.000 description 1
- 240000003377 Shepherdia canadensis Species 0.000 description 1
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- XQMIGRUKENWSIJ-UHFFFAOYSA-N aniline;pyrimidine Chemical class C1=CN=CN=C1.NC1=CC=CC=C1 XQMIGRUKENWSIJ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- ZCILODAAHLISPY-UHFFFAOYSA-N biphenyl ether Natural products C1=C(CC=C)C(O)=CC(OC=2C(=CC(CC=C)=CC=2)O)=C1 ZCILODAAHLISPY-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
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- 238000000205 computational method Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
- VBBRYJMZLIYUJQ-UHFFFAOYSA-N cyclopropanone Chemical compound O=C1CC1 VBBRYJMZLIYUJQ-UHFFFAOYSA-N 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 150000008056 dicarboxyimides Chemical class 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- XUZHLZDRCCUWEV-UHFFFAOYSA-N formaldehyde;methyl naphthalene-1-sulfonate Chemical compound O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 XUZHLZDRCCUWEV-UHFFFAOYSA-N 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a sterilization composition containing fenhexamid. Effective constituents of the sterilization composition are fenhexamid (A) and eugenol (B). The mass ratio of A and B is 1:50-100:1. The composition is obvious in effect increasing function, high in prevention effect, suitable for preventing various diseases on melons, fruits and vegetables, and especially suitable for preventing gray mold.
Description
Technical field
The present invention relates to a kind of bactericidal composition, relate in particular to a kind of bactericidal composition containing fenhexamid and eugenol.
Background technology
Due to gray mold is infected by the pathogen of Botrytis cinerea, belong to fungal disease, flower, really, leaf, stem all can fall ill.Fruit is caught an illness, Chinese olive is injured heavily, and residual column cap or petal are many first to be infected, backward fruit expansion, cause pericarp to be canescence, and have the mould layer of thick grey, and being the rotten shape of water, blade is fallen ill from blade tip, along becoming " V " shape inwardly to expand between vein, taupe, there is the alternate line shape line of the depth on limit, and sick key has a common boundary clearly demarcated.
Low temperature and high relative humidity is the pathogenetic major reason of grey mold, and the optimum temperature that ash arrhizus bacteria is grown is 16-23 DEG C, and 25 DEG C of above temperature are unfavorable for spreading of disease.Relative moisture continues very easily to occur in 90% above disease popular, has a strong impact on fruit yield and quality.
Fenhexamid, chemical name N (2,3-dioxy-4-antelope base phenyl)-1-methylcyclohexyl formamide, molecular formula C
14h
17c
12nO
2.This compound is novel amide-type systemic fungicide, very effective to the control of gray mold.
The concrete mechanism of action of fenhexamid it be unclear that.But a large amount of research shows that it has unique mechanism of action, there are bactericide benzimidazole, dicarboximide class, triazole type, aniline pyrimidine class, N-carbanilate class etc. without cross resistance with oneself.Controlling object is various gray molds and relevant stalk break, black spot etc.Be suitable for grape, xylocarp, strawberry, vegetables, oranges and tangerines, ornamental plants etc.To crop, the mankind, Environmental security, it is desirable comprehensive regulation medication.
Fenhexamid uses mainly as blade face bactericide, and its dosage is 500～1000g (a.i.)/hm
2, gray mold is had to special efficacy.
But the production that fenhexamid is current and use cost are all higher, resistance risk evaluation studies shows in addition, and long-term this medicament that uses separately has very large resistance risk.
The pesticide active ingredient combination of fenhexamid and other structure being carried out composite, is the effective mode of one that solves cost and resistance problem in its single dose application process.The pesticide active ingredient of different structure shows three kinds of type of action, i.e. summation action, synergistic effect and antagonism after mixing conventionally.Compound synergic is well filled a prescription, and can improve actual control efficiency, reduces the usage amount of agricultural chemicals, also contributes to delay the drug-fast generation of germ, is the important means of integrated control.
At present also there is no the fenhexamid report of preventing and treating disease mixed with eugenol both at home and abroad, do not carry out any relevant test yet, more there is no production and the use of Related product.
Summary of the invention
The object of this invention is to provide a kind of synergistic effect obvious, to the bactericidal composition that gray mold control efficiency is good, cost is low, resistance risk is low.
Another object of the present invention is to provide the application of this bactericidal composition.
Inventor is by a large amount of indoor biometrics and field control effectiveness test, finds that unexpectedly fenhexamid and eugenol in certain proportion after mixture, have significant synergistic effect to diseases such as gray molds.
Described eugenol, English name eugenol, chemical name Coryophyllic acid, molecular formula C
10h
12o
2, molecular weight 164.20.Eugenol low toxicity, to people and animals and Environmental security, can prevent and treat gray mold of cucumber effectively.
Fenhexamid and eugenol are bactericide well known in the art, can obtain by various commercial channel.
Technical scheme of the present invention is: a kind of bactericidal composition, contain active ingredient fenhexamid (A) and eugenol (B), and A and B mass ratio are 1: 50～100: 1, preferred proportion is 1: 30～20: 1.
The active ingredient of said composition coordinates with auxiliary agent and filler can be processed into the upper any formulation allowing of agricultural, and formulation has suspending agent, aqueous emulsion, wetting powder, water dispersible granules preferably.
In bactericidal composition of the present invention, the mass accumulation percentage composition of effective constituents A and B is 5%～80% preferably.
The formulation of above-mentioned bactericidal composition, except comprising effective constituents A and B, also comprises auxiliary agent and other material that contributes to drug effect to bring into play.Aqueous emulsion comprises organic solvent, dispersant, emulsifier and water; Suspending agent comprises water, dispersant, thickener, antifreezing agent and wetting agent; Wetting powder comprises wetting agent, dispersant and filler; Water dispersible granules comprises dispersant, disintegrant, filler and wetting agent.Below be all various compositions conventional in pesticidal preparations or that permission is used, be not particularly limited, concrete composition and consumption require to determine by simple experiment according to formula.For example:
Organic solvent can be selected one or more in isopropyl alcohol, dimethylbenzene, DMF, ring ethyl ketone, toluene, dimethyl sulfoxide (DMSO), methyl alcohol, ethanol, trimethyl cyclic ethylene ketone, NOP, 1-METHYLPYRROLIDONE, propyl alcohol, butanols, ethylene glycol, diethylene glycol, ethylene glycol monomethyl ether, butyl ether, ethyl acetate, vegetable oil.
Dispersant can be selected sodium lignin sulfonate, calcium lignosulfonate, pulls open powder, one or more in calcium dodecyl benzene sulfonate, polycarboxylate, alkyl benzene sulfonate calcium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO.
Emulsifier can be selected agricultural emulsifier NO．600 (phenyl phenol polyoxy ethyl ether), No. 1601 (phenethyl phenol polyoxy ethyl polypropylene-base ether) of agriculture breast, No. 500 (alkyl benzene calcium sulfonate) of agriculture breast, OP series phosphate (polyoxyethylene nonylphenol ether phosphate), No. 600 phosphates (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene rice ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, No. 400 (benzyl xylenol polyoxy ethyl ether) of agriculture breast, Nongru-700 number (alkyl phenolic resin polyoxy ethyl ether), No. 36 (phenethyl fluosite polyoxy ethyl ether) of peaceful breast, No. 1600 (phenethyl phenol polyoxy ethyl polypropylene-base ether) of agriculture breast, ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), No. 33 (alkylaryl polyoxyethylene polyoxypropylene ether) of agriculture breast, No. 34 (alkylaryl polyoxyethylene poly-oxygen propylene aether) of agriculture breast, sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), one or more in AEO series (fat alcohol alcohol APEO).
Antifreezing agent can be selected one or more in glycerine, urea, ethylene glycol, propane diols.
Wetting agent can select that methyl naphthalene sulfonate formaldehyde condensate, lauryl sodium sulfate, Negel, alkyl benzene calcium sulfonate, tea are withered, spaonin powder, silkworm excrement, soapberry powder, bay alcohol radical sodium sulphate, washing powder, pull open one or more in powder.
Disintegrant can be selected one or more in ammonium sulfate, urea, bentonite, aluminium chloride, citric acid, succinic acid, sodium bicarbonate.
Thickener can be selected in xanthans, CMC, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol one or more.
Filler can be selected one or more in White Carbon black, ridge soil, precipitated calcium carbonate, talcum, imvite or convex-concave rod stone, float stone, brickbat, sepiolite or bentonite and non-adsorptivity calcium soil or sand.
Composition described in the invention can finished product preparation form provide, be that in composition, each material is pre-mixed before use, in addition, the composition of composition also can provide with single dose form, before use, directly in bucket or tank, directly mix, be then diluted to required concentration.
Bactericidal composition of the present invention can be used for preventing and treating various plant diseases, is particularly useful for preventing and treating gray mold.Composition of the present invention can be used by common method, and as cast, injection, spraying, dusting, scatter or be fuming, its amount of application is with weather condition or crop state variation.
Compared with prior art, its advantage is in the present invention: 1, composition synergistic effect is obvious, and preventive effect significantly improves compared with single dose; 2, after drug effect improves, the effective ingredient consumption in field declines, and has reduced production and use cost, has reduced residue of pesticide and environmental pollution; 3, composition is made up of the active ingredient of different mechanism of action, and action site increases, and is conducive to overcome and delays the drug-fast generation of germ.
Embodiment
The pesticide active ingredient of different types of structure being carried out composite, is a kind of effective means that solves at present the problem such as cost and resistance in agricultural chemicals single dose application process.The pesticide active ingredient of different types of structure shows three kinds of type of action after mixing conventionally, i.e. summation action, synergistic effect and antagonism, but be specially which kind of effect, and unpredictable, only have by lot of experiments and just can know.Compound synergic is well filled a prescription, and can improve actual control efficiency, reduces the usage amount of agricultural chemicals, contributes to the generation of delaying drug resistance, is the important means of scientific prevention and cure damage by disease and insect.
The present composition has obvious synergistic function to ash arrhizus bacteria etc., and is not only the simple addition of two kinds of pharmacy effects, and this can be clear that from the result of following biologicall test experiment very much.But the present invention is limited to absolutely not these examples.
Biologicall test example 1: the Toxicity Determination of composition to melon ash arrhizus bacteria
Subjects is botrytis cinerea pers (Botrytis cinerea).
Test method: with reference to " the agricultural industry criteria NY/T1156.11-2008 of the People's Republic of China (PRC) ".Choose the consistent potted plant two leaf period cucumber seedlings of growth potential, 5 basins are selected in each processing, number for subsequent use.Under 50PSI pressure, spray with Potter spray tower, every basin 5mL.Test is processed referring to table 1, table 2, and each medicament arranges 5 concentration gradients.After 24h, carrying out inoculum density is 3 × 10
5the botrytis cinerea pers sporangia suspension of individual sporangium/mL.Taking the cucumber seedling that sprays equivalent clear water as blank.After inoculation, cucumber seedling being put into illumination humidistat cultivates.After 8d, according to the morbidity grade scale investigation disease index of gray mold of cucumber, and calculate control efficiency.
Gray mold of cucumber severity Scaling standard:
0 grade: blade is without scab;
1 grade: lesion area accounts for the area of whole blade below 5%;
3 grades: lesion area account for whole blade area 6%～10%;
5 grades: lesion area accounts for 11%～25% of whole blade area;
7 grades: lesion area accounts for 25%～50% of whole blade area;
9 grades: lesion area accounts for the more than 50% of whole blade area.
The expection effect (being theoretical control efficiency, %) of mixture of active principles use Colby formula determine and with the effect comparison of observing:
Colby formula: E=X+Y-X*Y/100
E: when active components A working concentration in composition is a, compositions contemplated effect when active component B working concentration is b.
X: effect when active components A using dosage is a.
Y: effect when active component B using dosage is b.
In the time that exceeding expection preventive effect, the actual control efficiency of observing illustrates that mixture has synergistic effect.
Toxicity test result is referring to table 1 and table 2.
The pot experiment measurement result of the independent reactive compound of table 1 to gray mold of cucumber
The composite pot experiment measurement result to gray mold of cucumber of table 2 fenhexamid and eugenol
| Proportioning | Activity component concentration in mixture | Practical effect | Expection effect |
| Sequence number | (ppm:ppm) | (％) | (％) |
| 1 | Fenhexamid 100: eugenol 1 | 92.7 | 88.5 |
| 2 | Fenhexamid 50: eugenol 1 | 80.6 | 73.9 |
| 3 | Fenhexamid 20: eugenol 1 | 68.5 | 57.1 |
| 4 | Fenhexamid 10: eugenol 1 | 49.2 | 36.7 |
| 5 | Fenhexamid 10: eugenol 10 | 53.8 | 44.9 |
| 6 | Fenhexamid 1: eugenol 10 | 36.4 | 29.8 |
| 7 | Fenhexamid 1: eugenol 30 | 69.6 | 55.3 |
| 8 | Fenhexamid 1: eugenol 50 | 75.1 | 69.8 |
| 9 | Fenhexamid 1: eugenol 100 | 79.3 | 84.2 |
Result of the test shows, fenhexamid and eugenol be composite control gray mold of cucumber within the scope of certain proportion, has synergistic effect.
In order to make object of the present invention, technical scheme and advantage clearer, the present invention describes by following concrete formulation examples, but the present invention is limited to absolutely not these examples.The following stated is only the good embodiment of the present invention, only in order to explain the present invention, can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that all any amendments of making within the spirit and principles in the present invention, be equal to replacement and improvement etc., within all should being included in protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Suspending agent embodiment
Each components such as active component, dispersant, defoamer, thickener and water are mixed in the ratio of formula, after sand milling or high speed shear, obtain semi-finished product, after analysis, add water and mix filtration and obtain suspending agent.
Example of formulations 1,15.3% fenhexamid eugenol suspending agent
Fenhexamid 0.3%, eugenol 15%, polyoxyethylene nonylphenol ether 8% (emulsifier), propane diols 2% (cosolvent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100% example of formulations 2,30.3% fenhexamid eugenol suspending agent
Fenhexamid 30%, eugenol 0.3%, polyoxyethylene nonylphenol ether 8% (emulsifier), propane diols 2% (cosolvent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100% example of formulations 3,30% fenhexamid eugenol suspending agent
Fenhexamid 15%, eugenol 15%, polyoxyethylene nonylphenol ether 8% (emulsifier), propane diols 2% (cosolvent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100% example of formulations 4,21% fenhexamid eugenol suspending agent
Fenhexamid 20%, eugenol 1%, polyoxyethylene nonylphenol ether 8% (emulsifier), propane diols 2% (cosolvent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%
Example of formulations 5,6.2% fenhexamid eugenol suspending agent
Fenhexamid 0.2%, eugenol 6%, polyoxyethylene nonylphenol ether 8% (emulsifier), propane diols 2% (cosolvent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%
Example of formulations 6,22% fenhexamid eugenol suspending agent
Fenhexamid 20%, eugenol 2%, polyoxyethylene nonylphenol ether 8% (emulsifier), propane diols 2% (cosolvent), xanthans 1% (thickener), organosilicon 2% (defoamer), water are supplemented to 100%
Aqueous emulsion embodiment
By each component proportion, solubilization of active ingredient, in solvent and cosolvent, is added to surfactant, mix and make oil phase.Water-soluble component and water mixing are made to water, then water is added in oil phase, limit edged stirs, and makes aqueous emulsion.
Example of formulations 7,5% fenhexamid eugenol aqueous emulsion
Fenhexamid 4.7%, eugenol 0.3%, DMF (solvent) 5%, cyclohexanol (solvent) 10%, glycerine (antifreezing agent) 5%, phenethyl phenol polyethenoxy ether (emulsifier) 10%, calcium dodecyl benzene sulfonate (wetting agent) 5%, water are supplemented to 100%
Example of formulations 8,10.5% fenhexamid eugenol aqueous emulsion
Fenhexamid 10%, eugenol 0.5%, turpentine oil (vegetable oil solvent) 5%, Jatropha curcas oil (vegetable oil solvent) 10%, glycerine (antifreezing agent) 5%, phenethyl phenol polyethenoxy ether (emulsifier) 10%, calcium dodecyl benzene sulfonate (wetting agent) 5%, water are supplemented to 100%
Water dispersible granules embodiment
Pesticide activity component, auxiliary agent and filler are mixed in proportion, through air-flow crushing, then add the water of 15-20%, make water dispersible granules product through kneading, granulation, dry, screening.Capital equipment: mixer, airslide disintegrating mill, kneader, Squeezinggranulator, drying equipment (drying room or fluid bed).
Example of formulations 9,80% fenhexamid eugenol water dispersible granules
Fenhexamid 78%, eugenol 2%, neopelex 4% (wetting agent), sodium lignin sulfonate 10% (dispersant), ammonium sulfate 3% (disintegrant), kaolin (filler) are to 100%
Example of formulations 10,50% fenhexamid eugenol water dispersible granules
Fenhexamid 45%, eugenol 5%, neopelex 4% (wetting agent), sodium lignin sulfonate 10% (dispersant), ammonium sulfate 3% (disintegrant), kaolin (filler) are to 100%
Wetting powder embodiment
Pesticide activity component, auxiliary agent, filler are mixed in proportion after air-flow crushing and mix and make wetting powder again.Capital equipment: mixer, airslide disintegrating mill.
Example of formulations 11,30% fenhexamid eugenol wetting powder
Fenhexamid 18%, eugenol 2%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dispersant), white carbon 8% (filler), kaolin (filler) are to 100%
Example of formulations 12,40% fenhexamid eugenol wetting powder
Fenhexamid 39.5%, eugenol 0.5%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dispersant), white carbon 8% (filler), kaolin (filler) are to 100%
Example of formulations 13,25% fenhexamid eugenol wetting powder
Fenhexamid 20%, eugenol 5%, bay alcohol radical sodium sulphate 4% (wetting agent), mersolates 7% (dispersant), white carbon 8% (filler), kaolin (filler) are to 100%
Field application examples 1: the composite field control effectiveness test to gray mold of cucumber of fenhexamid and eugenol
Test site Foshan.Test medicine and consumption are in table 3, and repeat 4 communities of every processing, 20 square metres of each community areas.Carry out dispenser for the first time at disease initial stage of origination, even spraying, till being sprayed onto blade and dripping, is treated to blank with clear water.After 7 days, execute medicine for the second time.Before the medicine for the first time and for the second time incidence of 7 days investigation gray molds of cucumber after medicine.Every community adopts 5 samplings, every some investigation two strains, and all blades are investigated in every strain, and the percentage that accounts for whole leaf area with lesion area carrys out classification record.Calculate each processing disease index and control efficiency.
Grade scale:
The killed stage division of leaf portion (taking blade as unit):
0 grade: without scab;
1 grade: single blade has 3 of scabs;
3 grades: single blade has scab 4-6;
5 grades: single blade has scab 7-10;
7 grades: single blade has scab 11-20, part is intensive in flakes;
9 grades: single blade has the intensive leaf area that accounts for of scab more than 1/4th.
Drug effect computational methods:
As can be seen from Table 3: fenhexamid, eugenol single dose are respectively 77.1%, 70.9% to the preventive effect of gray mold of cucumber, and embodiment of the present invention bactericidal composition is all significantly increased in preventive effect, and minimum preventive effect is 84.6%, has been up to 92.0%.The result of field trial fully shows, fenhexamid and eugenol are composite has significant synergistic function afterwards to gray mold of cucumber, and in the situation that mu effective ingredient consumption reduces compared with single dose, control efficiency significantly improves.Therefore, the present composition have reduce costs, the beneficial effect of delaying drug resistance, minimizing spraying times and residue of pesticide, expanding prevention spectrum.
The composite field test results to gray mold of cucumber of table 3 fenhexamid and eugenol
Claims (5)
1. a bactericidal composition, is characterized in that: contain active ingredient fenhexamid (A) and eugenol (B), the mass ratio of A and B is 1: 50～100: 1.
2. bactericidal composition according to claim 1, is characterized in that: A and B mass ratio are 1: 30～20: 1.
3. according to the bactericidal composition described in claim 1 to 2 any one, it is characterized in that: in composition, A and B mass accumulation percentage composition are 5～80%.
4. according to the bactericidal composition described in claim 3 any one, it is characterized in that: the active ingredient of said composition and auxiliary agent are processed into suspending agent, aqueous emulsion, wetting powder or water dispersible granules.
5. the application of bactericidal composition according to claim 1 in control gourd, fruit and vegetable gray mold.
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