CN104826542A - Reagent continuous quantitative injection device - Google Patents
Reagent continuous quantitative injection device Download PDFInfo
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- CN104826542A CN104826542A CN201510196205.6A CN201510196205A CN104826542A CN 104826542 A CN104826542 A CN 104826542A CN 201510196205 A CN201510196205 A CN 201510196205A CN 104826542 A CN104826542 A CN 104826542A
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- keyset
- syringe
- fixed plate
- bottom plate
- injection device
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Abstract
The invention discloses a reagent continuous quantitative injection device. The device comprises a power mechanism, at least one injection syringe and a support connection mechanism. The support connection mechanism comprises an upper fixing plate, a lower fixing plate and an adapter plate. The power mechanism comprises a motor and a power output shaft. The injection syringe comprises a syringe needle, a syringe cylinder, a piston rod and a piston fixed to the end of the piston rod. The upper fixing plate is fixed above a microfluidic chip by a support rod. The lower fixing plate is located below the upper fixing plate and is fixedly connected to the upper fixing plate by a connection rod. The device utilizes the power mechanism and the at least one injection syringe. The power mechanism is controlled by an upper computer and drives the injection syringe so that an injection process is finished. The device realizes continuous automatic injection. The power mechanism can synchronously drive one or more syringes so that injection efficiency is further improved.
Description
Technical field
The present invention relates to a kind of injection device, specifically, relate to a kind of reagent continuous quantitative injection device.
Background technology
Microflow control technique is the technology based on micro electronmechanical processing (MEMS), and chip micro-functional modules such as microchannel, microelectrode, Micropump, micro-valve, micro-accumulator tank, micro-detection module and connector is integrated in micro-total analysis system on chip material by maintaining processing.Due to micro-fluidic chip comparatively conventional chemical biological analyser want efficient quick, save the advantage such as reagent and cost, high integration and high precision, not only receive the extensive research of domestic and international expert recent years, and the application in biological and chemical field obtains fast development.
The calibrated shot operation of microfluid is the core that microfluidic chip analysis technology realizes, and is the prerequisite that micro-fluidic chip realizes ratio of reagents mixing.Up to the present, not a kind of injection technique being directed to reagent continuous and quantitative in micro-fluidic chip microchannel specially, traditional technology utilizes mechanical type syringe or titrator to inject quantitative reagent in microchannel, thus realize the ratio mixing of solution, the method injection efficiency is low, injections difficult, sealing is poor simultaneously, and during injection, syringe needle easily swings and causes leakage or inject bubble.And the automaticity of the method is lower, the mixing in the channel of microfluid reagent cannot realize directly simple control, and the reagent in microfluid can not mix completely.
Summary of the invention
The present invention utilizes mechanical type syringe or the low technical problem of titrator injection efficiency in order to the calibrated shot solving existing microfluid, proposes a kind of reagent continuous quantitative injection device, can solve the problem.
In order to solve the problems of the technologies described above, the present invention is achieved by the following technical solutions:
A kind of reagent continuous quantitative injection device, comprise actuating unit, at least one syringe, and support and connection mechanism, described support and connection mechanism comprises upper mounted plate, bottom plate, and keyset, described actuating unit comprises motor and power output shaft, described syringe comprises syringe needle, syringe, piston rod, and be fixedly arranged on the piston of described piston rod end, fixed plate is fixed on the top of micro-fluidic chip by support bar, described bottom plate is positioned at the below of fixed plate, and be fixedly connected with fixed plate by connecting rod, described keyset is between fixed plate and bottom plate, and described keyset has the pilot hole passed for holding described support bar, described motor is fixedly arranged on fixed plate, fixed plate, keyset, coaxially arrange with bottom plate, and center has centre bore, described power output shaft is successively through fixed plate, keyset, with the centre bore of bottom plate, the outer surface of described power output shaft has external screw thread, the inner surface of the centre bore of keyset has the internal thread matched with described external screw thread, described syringe is fixedly connected with described bottom plate, described piston rod is fixedly connected with described keyset, described motor is connected with host computer.
Further, the lower surface of fixed plate and/or the upper surface of described bottom plate are installed with proximity switch respectively, and described proximity switch is connected with described host computer.
Further, described motor is micro-step motor.
Further, the upper surface of micro-fluidic chip is provided with protection sleeve, described power output shaft stretches in described protection sleeve, and has gap between the end of described power output shaft and microfluidic control chip.
Further, described syringe needle is positioned at the top of microchannel on microfluidic control chip, and described syringe needle stretches in the groove of described microchannel.
Compared with prior art, advantage of the present invention and good effect are: reagent continuous quantitative injection device of the present invention, by arranging actuating unit and at least one syringe, actuating unit accepts the control of host computer, injector-actuated completes injection, can realize continuous automatic injection, and actuating unit can drive one and above syringe simultaneously, further increases injection efficiency.
After reading the detailed description of embodiment of the present invention by reference to the accompanying drawings, the other features and advantages of the invention will become clearly.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is a kind of example structure schematic diagram of reagent continuous quantitative injection device proposed by the invention;
Fig. 2 is the stereogram of a kind of embodiment of reagent continuous quantitative injection device proposed by the invention.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment one, the present embodiment proposes a kind of reagent continuous quantitative injection device, as shown in Figure 1, comprise actuating unit 10, at least one syringe 20, and support and connection mechanism 30, described support and connection mechanism 30 comprises upper mounted plate 301, bottom plate 302, with keyset 303, described actuating unit 10 comprises motor 101 and power output shaft 102, described syringe 20 comprises syringe needle 201, syringe 202, piston rod 203, and be fixedly arranged on the piston 204 of described piston rod 203 end, fixed plate 301 is fixed on the top of micro-fluidic chip 60 by support bar 401, described bottom plate 302 is positioned at the below of fixed plate 301, and be fixedly connected with fixed plate 301 by connecting rod 402, described keyset 303 is between fixed plate 301 and bottom plate 302, and described keyset 303 has the pilot hole 303b passed for holding described support bar 401, described motor 101 is fixedly arranged on fixed plate 301, fixed plate 301, keyset 303, coaxially arrange with bottom plate 302, and center has centre bore, described power output shaft 102 is successively through fixed plate 301, keyset 303, with the centre bore of bottom plate 302, the outer surface of described power output shaft 102 has external screw thread, the inner surface of the centre bore of keyset 303 has the internal thread matched with described external screw thread, described syringe 202 is fixedly connected with described bottom plate 302, described piston rod 203 is fixedly connected with described keyset 303, described motor 101 is connected with host computer.The reagent continuous quantitative injection device of the present embodiment, motor 101 drives power output shaft 102 to rotate, under the internal thread of keyset 303 coordinates with the externally threaded of power output shaft 102, keyset 303 is driven to move up and down, and then piston rod 203 has moved up and down action of injection in syringe 202, therefore keyset 303 can promote piston rod 203 and moves reciprocatingly under the driving of motor 101, thus complete continuous action of injection, in injection process, host computer is by controlling the rotating speed of motor 101, thus controls reagent injector speed.The reagent continuous quantitative injection device of the present embodiment, by arranging actuating unit and at least one syringe, actuating unit accepts the control of host computer, injector-actuated completes injection, continuous automatic injection can be realized, and actuating unit can drive one and above syringe, further increases injection efficiency simultaneously.
Containing flow regulation button in the control system of host computer, periodical injections button, flow setting and Timing button etc., if require that the reagent of different proportion mixes in experiment, the rotating speed control injection speed of stepping motor can be reconciled by host computer setting procedure, and the opening and closing of the corresponding micro-valve 50 of time switch come according to mixing ratio presetting the priority step of reagent sample introduction, and we can also pass through host computer setting procedure, thus complete the injection of reagent, the multi-series steps such as the extraction of reagent and the cleaning of instrument.
Preferably in the present embodiment, the lower surface of fixed plate 301 and/or the upper surface of described bottom plate 302 are installed with proximity switch 304 respectively, and described proximity switch 304 is connected with described host computer.Proximity switch is for detecting the position of keyset 303, produce when preventing keyset 303 from moving to upper mounted plate 301 or bottom plate 302 and collide and damage equipment, when keyset 303 moves up to restriction position, the proximity switch be arranged on upper mounted plate 301 can detect the approach signal of keyset 303, and produce detection signal and be sent to host computer, reversed by PC control motor 101, and then control keyset 303 counter motion, or control motor 101 to stop, itself and upper mounted plate 301 is made to remain within the scope of safe distance, as a same reason, when keyset 303 moves downwardly to restriction position, the proximity switch be arranged on bottom plate 302 can detect the approach signal of keyset 303, and produce detection signal and be sent to host computer, reversed by PC control motor 101, and then control keyset 303 counter motion, or control motor 101 to stop, itself and bottom plate 302 are remained within the scope of safe distance.
Preferably in the present embodiment, described motor 101 is micro-step motor, and its step-length is little, controls more accurate.
Because motor 101 drives power output shaft 102 to rotate; and then realize piston rod 203 action; other devices are damaged in its end when rotating in order to prevent power output shaft 102; or prevent from accidentally injuring experimenter; the upper surface of micro-fluidic chip 60 is provided with protection sleeve 601; described power output shaft 102 stretches in described protection sleeve 601, and has gap between the end of described power output shaft 102 and microfluidic control chip 60.
In order to produce the problem of bubble when solving injection at present, syringe needle 201 described in the present embodiment is positioned at the top of microchannel 602 on microfluidic control chip 60, and described syringe needle 201 stretches in the groove of described microchannel 602.Therefore syringe needle 201 and microchannel 602 compact siro spinning technology, form sealing area, with the generation of Anti-bubble.
Certainly; above-mentioned explanation is not limitation of the present invention; the present invention is also not limited in above-mentioned citing, the change that those skilled in the art make in essential scope of the present invention, remodeling, interpolation or replacement, also should belong to protection scope of the present invention.
Claims (5)
1. a reagent continuous quantitative injection device, it is characterized in that: comprise actuating unit, at least one syringe, and support and connection mechanism, described support and connection mechanism comprises upper mounted plate, bottom plate, and keyset, described actuating unit comprises motor and power output shaft, described syringe comprises syringe needle, syringe, piston rod, and be fixedly arranged on the piston of described piston rod end, fixed plate is fixed on the top of micro-fluidic chip by support bar, described bottom plate is positioned at the below of fixed plate, and be fixedly connected with fixed plate by connecting rod, described keyset is between fixed plate and bottom plate, and described keyset has the pilot hole passed for holding described support bar, described motor is fixedly arranged on fixed plate, fixed plate, keyset, coaxially arrange with bottom plate, and center has centre bore, described power output shaft is successively through fixed plate, keyset, with the centre bore of bottom plate, the outer surface of described power output shaft has external screw thread, the inner surface of the centre bore of keyset has the internal thread matched with described external screw thread, described syringe is fixedly connected with described bottom plate, described piston rod is fixedly connected with described keyset, described motor is connected with host computer.
2. reagent continuous quantitative injection device according to claim 1, is characterized in that: on the lower surface of fixed plate and/or the upper surface of described bottom plate, be installed with proximity switch respectively, described proximity switch is connected with described host computer.
3. reagent continuous quantitative injection device according to claim 2, is characterized in that: described motor is micro-step motor.
4. reagent continuous quantitative injection device according to claim 1; it is characterized in that: on the upper surface of micro-fluidic chip, be provided with protection sleeve; described power output shaft stretches in described protection sleeve, and has gap between the end of described power output shaft and microfluidic control chip.
5. the reagent continuous quantitative injection device according to any one of claim 1-4, is characterized in that: described syringe needle is positioned at the top of microchannel on microfluidic control chip, and described syringe needle stretches in the groove of described microchannel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510196205.6A CN104826542A (en) | 2015-04-23 | 2015-04-23 | Reagent continuous quantitative injection device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510196205.6A CN104826542A (en) | 2015-04-23 | 2015-04-23 | Reagent continuous quantitative injection device |
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| CN104826542A true CN104826542A (en) | 2015-08-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510196205.6A Pending CN104826542A (en) | 2015-04-23 | 2015-04-23 | Reagent continuous quantitative injection device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106383464A (en) * | 2016-09-18 | 2017-02-08 | 山东省科学院能源研究所 | System for automatic pumping of liquid based on ARM single-chip microcomputer, control method, and application |
| CN107321399A (en) * | 2017-07-14 | 2017-11-07 | 西北工业大学 | The High Precision Automatic sampling system of multicomponent towards centrifugal type microfludic chip optional position |
| CN109125860A (en) * | 2018-09-27 | 2019-01-04 | 佛山科学技术学院 | It is a kind of can calibrated shot drug syringe |
| CN109602404A (en) * | 2018-12-21 | 2019-04-12 | 上海百铭信息科技有限公司 | A kind of intelligence emergency watch |
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| WO1993006940A1 (en) * | 1991-09-30 | 1993-04-15 | Unes A/S | Dispensing device for dispensing at least two fluids |
| CN103032289A (en) * | 2012-12-28 | 2013-04-10 | 深圳市锦瑞电子有限公司 | Plunger pump and hematology analyzer with plunger pump |
| CN203098175U (en) * | 2012-10-29 | 2013-07-31 | 北京中盛华旭电子科技有限公司 | Metering pump with novel stepping motor control structure |
| CN203130405U (en) * | 2013-04-08 | 2013-08-14 | 齐齐哈尔医学院 | Dual-injection pump |
| CN203463247U (en) * | 2013-09-25 | 2014-03-05 | 中国科学技术大学 | Injection pump and injection system |
| CN204735190U (en) * | 2015-04-23 | 2015-11-04 | 山东省科学院海洋仪器仪表研究所 | Continuous quantitative injection device of reagent |
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2015
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993006940A1 (en) * | 1991-09-30 | 1993-04-15 | Unes A/S | Dispensing device for dispensing at least two fluids |
| CN203098175U (en) * | 2012-10-29 | 2013-07-31 | 北京中盛华旭电子科技有限公司 | Metering pump with novel stepping motor control structure |
| CN103032289A (en) * | 2012-12-28 | 2013-04-10 | 深圳市锦瑞电子有限公司 | Plunger pump and hematology analyzer with plunger pump |
| CN203130405U (en) * | 2013-04-08 | 2013-08-14 | 齐齐哈尔医学院 | Dual-injection pump |
| CN203463247U (en) * | 2013-09-25 | 2014-03-05 | 中国科学技术大学 | Injection pump and injection system |
| CN204735190U (en) * | 2015-04-23 | 2015-11-04 | 山东省科学院海洋仪器仪表研究所 | Continuous quantitative injection device of reagent |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106383464A (en) * | 2016-09-18 | 2017-02-08 | 山东省科学院能源研究所 | System for automatic pumping of liquid based on ARM single-chip microcomputer, control method, and application |
| CN107321399A (en) * | 2017-07-14 | 2017-11-07 | 西北工业大学 | The High Precision Automatic sampling system of multicomponent towards centrifugal type microfludic chip optional position |
| CN109125860A (en) * | 2018-09-27 | 2019-01-04 | 佛山科学技术学院 | It is a kind of can calibrated shot drug syringe |
| CN109602404A (en) * | 2018-12-21 | 2019-04-12 | 上海百铭信息科技有限公司 | A kind of intelligence emergency watch |
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Application publication date: 20150812 |
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