CN104825927A - Traditional Chinese medicine compounded preparation capable of enhancing hematopoietic function - Google Patents
Traditional Chinese medicine compounded preparation capable of enhancing hematopoietic function Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine compounded preparation capable of enhancing a hematopoietic function, wherein the compounded preparation includes following raw material medicines: 30-60 parts of astragalus membranaceus, 9-18 parts of angelica sinensis, 15-24 parts of ligustrum lucidum ait, 15-24 parts of fructus lycii, 15-24 parts of curculigo orchioides, 15-24 parts of epimedium, 9-18 parts of rhizoma polygonati, 15-24 parts of scorched medicated leaven, 15-24 parts of scorched hawthorn, 15-24 parts of scorched malt, 15-24 parts of fried atractylodes macrocephala, 9-18 parts of pericarpium citri reticulatae, 9-18 parts of poria cocos, and 3-9 parts of date. The compounded preparation can be prepared into granules through a conventional method comprising the following steps: (1) decocting the 14 raw material medicines with water for two times, wherein each decoction lasts for 1.5 h; (2) mixing the two decoctions and filtering the mixed decoctions; (3) concentrating the filtrate to obtain clear paste being 1.25-1.30 in relative density (at 60 DEG C); (4) pressure-reduced-drying the clear paste at 70 DEG C and grinding the dried clear paste into fine powder; (5) adding dextrin and uniformly mixing the mixture, and performing granulation; and (6) drying the granules at 60 DEG C. The compounded preparation has the effects of boosting qi and fortifying spleen, nourishing blood and engendering fluid, can promote and improve the hematopoietic function of body, can increase the number of leukocyte, and reduces toxic and side effects of a chemotherapeutic drug.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, special for being
a kind of compound Chinese medicinal preparation that can improve hemopoietic function.
Background technology
Leukopenia is complication common in chemotherapy of tumors process, and cyclophosphamide is clinical conventional medicine for treating tumor, and its main adverse reaction is bone marrow depression and immunologic hypofunction, and then causes leukopenia.Modern medicine is thought, leukopenia and hemopoietic function of bone marrow suppress or obstacle has direct relation.Cyclophosphamide is conventional antitumor drug, this medicine non-activity in vitro, enter after in body and activate in liver or blood, generate alkylating metabolite, and then performance antineoplastic action, its main adverse reaction is the hemopoietic function of major injury medullary cell, causes leukopenia, cause the serious consequences such as infection, affect therapeutic effect.Therefore, exploitation one is needed can to improve hemopoietic function, the medicine of leukocyte increasing.
Summary of the invention
The technical problem to be solved in the present invention is to provide
a kind of compound Chinese medicinal preparation that can improve hemopoietic function, said preparation can improve body hemopoietic function, leukocyte increasing, alleviate chemotherapeutics toxicity.
For solving above technical problem, the technical solution used in the present invention is:
a kind of compound Chinese medicinal preparation that can improve hemopoietic function, crude drug comprises: Radix Astragali 30-60 part, Radix Angelicae Sinensis 9-18 part, Fructus Ligustri Lucidi 15-24 part, Fructus Lycii 15-24 part, Rhizoma Curculiginis 15-24 part, Herba Epimedii 15-24 part, Rhizoma Polygonati 9-18 part, Massa Medicata Fermentata (parched to brown) 15-24 part, Fructus Crataegi (parched to brown) 15-24 part, Fructus Hordei Germinatus (parched to brown) 15-24 part, Rhizoma Atractylodis Macrocephalae (parched) 15-24 part, Pericarpium Citri Reticulatae 9-18 part, Poria 9-18 part, Fructus Jujubae 3-9 part.Conventional method can be adopted to make granule.
As preferred scheme, crude drug comprises: the Radix Astragali 30 parts, Radix Angelicae Sinensis 10 parts, Fructus Ligustri Lucidi 15 parts, Fructus Lycii 15 parts, Rhizoma Curculiginis 15 parts, Herba Epimedii 15 parts, Rhizoma Polygonati 10 parts, Massa Medicata Fermentata (parched to brown) 15 parts, Fructus Crataegi (parched to brown) 15 parts, Fructus Hordei Germinatus (parched to brown) 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Pericarpium Citri Reticulatae 10 parts, 10 parts, Poria, 3 parts, Fructus Jujubae.
As the preferred scheme of another kind, during preparation, 14 taste crude drug are decocted with water secondary, each 1.5 hours, collecting decoction, filter, it is 1.25 ~ 1.30(60 DEG C that filtrate is condensed into relative density) clear paste; 70 DEG C of drying under reduced pressure, are ground into fine powder; Add dextrin mixing again, granulate; 60 DEG C of dryings, to obtain final product.
Invention formulation function cures mainly: replenishing QI to invigorate the spleen, nourishing blood to promote the production of body fluid, promotes body hemopoietic function.Can be used for the incoordination between the spleen and stomach because a variety of causes causes, pallor tachypnea, neurolysis, insufficiency of vital energy and blood and the hematopoietic disorder caused because of Radiotherapy chemotherapy, hemoglobin and low leukocyte counts person.
Usage and dosage: every day 2-3 time, each 5-10 gram, warm boiled water.
Fang Xie: we are made up of 14 kinds of Chinese medicines such as the Radixs Astragali.In side, Radix Astragali tonifying Qi and lifting yang, promotes the production of body fluid and nourishes blood, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, returns lung, spleen channel.Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, GUIXIN, liver, spleen channel, and two taste medicines share composition China's Chinese medicine recipe " Radix Angelicae Sinensis decoction for tonifying blood ", are monarch drug in we; Fructus Ligustri Lucidi nourishing the liver and kidney, improving eyesight black hair, returns Liver and kidney warp, Fructus Lycii nourishing the liver and kidney, and replenishing vital essence to improve eyesight returns Liver and kidney warp.Rhizoma Curculiginis kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness, returns liver,kidney,spleen warp.Herba Epimedii kidney-replenishing, bone and muscle strengthening, wind-damp dispelling, returns Liver and kidney warp.Rhizoma Polygonati boosting qi and nourishing yin, spleen invigorating lung moistening, kidney tonifying, returns Liver and kidney warp.A few taste medicine plays liver and kidney tonifying altogether, bone and muscle strengthening in we, the function of kidney-replenishing, is ministerial drug.Fructus Crataegi (parched to brown) promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, changes turbid blood fat reducing, returns spleen, stomach, Liver Channel.Fructus Hordei Germinatus (parched to brown) relieving dyspepsia, spleen benefiting and stimulating the appetite, returns spleen, stomach warp, Massa Medicata Fermentata (parched to brown) relieving dyspepsia, and circulation of qi promoting is whetted the appetite, and returns spleen, stomach warp.Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, returns taste warp.Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, returns lung, spleen channel.Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, returns spleen, stomach, heart channel.Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, GUIXIN, lung, spleen, kidney channel.A few taste share, and plays digestion-promoting spleen-invigorating altogether, promoting diuresis to eliminate damp pathogen, the effect that nourishing the stomach is calmed the nerves, and is adjuvant.Full side share, and gathers replenishing QI to invigorate the spleen altogether, nourishing blood to promote the production of body fluid, improves and promote the effect of body hemopoietic function.
The taste Chinese angelica blood supplementing Chinese medicine that adds of the present invention is the pure Chinese medicinal preparation made based on China's traditional Chinese medicine theory, by observing its impact on caused by cyclophosphamide leukopenia model, inquire into this medicine to improving body hemopoietic function, leukocyte increasing, alleviating the effect of chemotherapeutics toxicity.
materials and methods
1.1 experiment material
1.1.1 instrument and equipment
HEMAVET950FS Full automatic animal blood analyser, Drew company of Britain; Electronic balance, Changshu Shuan Jie test instrunment factory; OlympusBX51 microscope: Japanese Olympus company.
1.1.2
reagent reagent
Add taste Chinese angelica blood supplementing Chinese medicine, prescription is Radix Angelicae Sinensis 10g, Radix Astragali 30g, Fructus Ligustri Lucidi 15g, Fructus Lycii 15g, Rhizoma Curculiginis 15g, Herba Epimedii 15g, Rhizoma Polygonati 10g, Pericarpium Citri Reticulatae 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Fructus Jujubae 3g, Massa Medicata Fermentata (parched to brown) 15g, Fructus Hordei Germinatus (parched to brown) 15g, Fructus Crataegi (parched to brown) 15g.Experimental drug is prepared voluntarily, and after boiling extraction, water-bath is concentrated to desired content for experiment.
Cyclophosphamide, Hengrui Medicine Co., Ltd., Jiangsu Prov. produces, and lot number 13042325, specification: 200mg/ props up, uses front normal saline to be configured to the solution of 10mg/ml, now with the current.
DIYU SHENGBAI PIAN, Chengdu Tianfu Diao Pharmaceutical Group Co produces, and lot number 13080627, specification 0.1g/ sheet, after being ground into fine powder, is configured to drinking water the suspension that concentration is 0.1g/15ml.
Reagent C ELLYSE-XI3TM Lytic Agent, CELLYSE-XII3TM Lytic Agent, MULTI-CELL3TM Diluent, CD CLEANTM Deproteinizer, LOT:6505.
1.1.3
laboratory animal
Select healthy adult Kunming mouse, body weight 18-22g, male and female half and half, Test Animal Centre, Academy of Military Medical Sciences, P.L.A provides.The animal quality certification number: SCXK (army) 2012-0004.All animals are for testing prospective adaptation test chamber environment 3 days (containing buying day).Conforming period, animal sub-cage rearing, 5, every cage, all animals are at the equal free choice feeding of experimental session, drinking-water.The circulation adaptability that animal housing maintains 12 h light and 12 h dark is raised and train, room temperature 20-26 DEG C, and temperature difference per day is less than 3 DEG C, relative humidity 40-70%.Feedstuff is Co
60radiosterilization Mus full-valence pellet feed, to pull together feed corporation,Ltd purchased from Beijing Australia of section, the quality certification number: SCXK (capital) 2009-0012.Bedding and padding are through Co
60the wood shavings of radiosterilization, to pull together feed corporation,Ltd purchased from Beijing Australia of section.Drinking water is the Drinking Water after high pressure steam sterilization.
1.2
experimental technique
1.2.1 grouping and administration
Animal is divided into 6 groups at random, often organize 10, be respectively negative control group, model control group, positive controls (5 times of quantity), tested material low dose group (2.5 times of quantity), dosage group (5 times of quantity) and tested material high dose group (10 times of quantity) in tested material, tested material high dose group gavage adds taste Chinese angelica blood supplementing Chinese medicine extraction liquid stock solution, in tested material, dosage group gavage gives the extracting solution stock solution with the dilution of purified water equimultiple, tested material low dosage gavage gives the extracting solution stock solution with purified water 4 times dilution, positive controls gavage gives the DIYU SHENGBAI PIAN suspension of 0.1g/15ml, negative control group, model control group gavage gives drinking water, concussion mixing in administration process, gavage amount 15ml/kg BW, from test administration second day, last till that experiment terminates the previous day.
1.2.2
modeling method
Except feminine gender group, test the 8th day model control group, positive controls and the equal intraperitoneal injection of cyclophosphamide 50mg/kg of high, medium and low tested material treated animal; Afterwards every injection in a three days cyclophosphamide, inject three times altogether, set up the leukopenic model of caused by cyclophosphamide
[5,6]; Each group continuation gavage gives corresponding medicinal liquid simultaneously.
1.2.3
testing index
1.2.3.1 general body condition and body weights
At duration of test, every 1 day mouse weights once, and observe the change of the mice mental status and body condition.Calculate each time point body weight rate of increase.
Body weight rate of increase=(n-th day body weight-, 1 day body weight) × the 100%/1st day body weight
1.2.3.2 peripheral blood leucocyte measures
Respectively at the 1st day, the 12nd day, the 16th day, the 20th day eye socket blood sampling 20uL, measure mouse peripheral blood total white blood cells (WBC).
1.2.3.3 on the impact of immune organ
24h after Yu Weici blood sampling; Cervical dislocation puts to death mice, wins spleen, thymus is weighed, and calculates spleen index and thymus index.
Organ index=internal organs weight in wet base × 100%/last body weight
1.2.3.4 on the impact of bonemarrow nucleated cells number
Get mouse femur bone marrow, through the dyeing of Switzerland Ji nurse Sa dye liquor after smear, under light microscopic, carry out medullary cell inspection with oily mirror, counting bonemarrow nucleated cells number.
1.2.4
statistical analysis technique
All data are all described in the mode of mean ± standard deviation (mean ± SD), adopt one factor analysis of variance to add up between group, variant person between group, adopt Dunnet t inspection to carry out each group further and compare with between model group.SPSS17.0 statistical software is adopted to add up, inspection level α=0.05.
2.
results and analysis
the general body condition of 2.1 animal
2.1.1 general body condition
After giving cyclophosphamide, tested material group and model control group mice great majority occur that fur is fluffy, less dynamic asthenia, lethargy, fiddle-footed performance, there was no significant difference between each group.
2.1.2
body weight
From table 1, table 2, the equal no difference of science of statistics of each time point each treated animal body weight in process of the test, but can find out model group Mouse Weight rate of increase and negative organize compare oneself test within the 13rd day, start to have significant difference (
p<0.05), positive group is slow with each more negative group of dose of test thing group body weight rate of increase, but has larger improvement compared with model group.
table 1add the impact (n=10, g) of taste Chinese angelica blood supplementing Chinese medicine on each group of Mouse Weight
table 2add the impact (n=10, %) of taste Chinese angelica blood supplementing Chinese medicine on each group of Mouse Weight rate of increase.
2.2
add taste Chinese angelica blood supplementing Chinese medicine to the leukocytic impact of mouse peripheral blood
From in table 3, test the 1st day respectively the equal no difference of science of statistics of group mouse peripheral blood leukocyte count (
p>0.05).Injection cyclophosphamide after the 4th day, model group compare with negative group have significant difference (
p<0.05), show that leukopenia mouse model builds, along with increasing of cyclophosphamide number of times, model remains stable.Administration the 12nd day, tested group of high and low dose group compares with model group, all has rising in various degree, administration 16d, 20d, in, low dose group compares with model group, leukocyte count raises has significant difference.Show that tested material can raise the leukocyte count of caused by cyclophosphamide leukopenia model mice preferably, and in time in increasing trend.
table 3add impact (n=10,10 of taste Chinese angelica blood supplementing Chinese medicine on each group of mouse peripheral blood quantity of leucocyte
9/ L)
Note: compare with model group:
* p<0.05.
2.3
add taste Chinese angelica blood supplementing Chinese medicine to the impact of mouse immune organ
Model group spleen index compares with negative group the trend having reduction as shown in Table 4, and tested material high and low dose is improved the trend that spleen index reduces.
table 4add the impact (n=10, %) of taste Chinese angelica blood supplementing Chinese medicine on each group of mouse immune organ
2.4 add taste Chinese angelica blood supplementing Chinese medicine to the impact of bone marrow cells in mice
By
table 5known model group bone marrow nucleated cell percentage ratio is organized with feminine gender and is significantly reduced, and each dosage group of tested material compares with model group, all has significant difference.
table 5add the impact (n=10, %) of taste Chinese angelica blood supplementing Chinese medicine on each group of mouse bone marrow cells nucleated cell
Note: compare with model group:
* p<0.05.
3.
discuss
We are side based on Radix Angelicae Sinensis decoction for tonifying blood, according to tumor patient impact by toxic and side in chemotherapy process, causes hemopoietic function to suppress, immunologic hypofunction, the disease of deficiency of qi and blood, adds the product of the replenishing QI to invigorate the spleen such as Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, and composition adds taste Chinese angelica blood supplementing side.Can also according to the difference of each individual patients in clinical practice, plus-minus of suiting the medicine to the illness, often can obtain good curative effect.This research is exactly on the basis of Clinical Experience, selects the representational prescription of most, composition " adding taste Chinese angelica blood supplementing side ".Application cyclophosphamide causes mouse bone marrow cells inhibition, observe the impact of this prescription on model mice hemopoietic function, observe to simultaneity factor the impact on Mouse Weight, immune organ weight, bonemarrow nucleated cells number etc. after drug effect, for this medicine provides experimental basis in the reasonability of clinical middle application.
From experimental result, after giving cyclophosphamide modeling, model group Animal performance goes out body weight growth and slows down, peripheral white blood cell reduces, important immune organ weight and bonemarrow nucleated cells number such as to be all suppressed at the toxicity, create suppression to the body hemopoietic function of animal after showing cyclophosphamide administration, administration each dosage treated animal body weight rate of increase is all greater than model group, and the amplitude of weight loss has the trend of alleviation.Analysis is the invigorating the spleen and benefiting QI composition in prescription, as the compositions such as the Rhizoma Atractylodis Macrocephalae, Poria, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) serve effect.Aspect is affected on leukocytic, when administration high dose group first time is detected, leukocyte count increases to some extent, and leukocyte count reduces on the contrary during second and third detection, in, low dosage administration treated animal peripheral blood leucocyte then shows the trend steadily increased, particularly middle dosage group, compare with model group and have significant difference, show in the use of this prescription, dosage is too high or too low all can not reach the effect of desirable improvement hemogram.Analyze that dosage is too high may produce untoward reaction to body, thus have influence on curative effect; And dosage is too low may not reach required drug effect, point out in process of clinical application, Chinese medicine preparation also should be taken in strict accordance with the dose requirements of regulation, too high or too lowly all can not obtain desirable effect.
From to the immune organ weight index of mice and bonemarrow nucleated cells number, administration respectively organizes mouse spleen index, thymus index compares with model group, there was no significant difference.But bonemarrow nucleated cells number is all significantly higher than model group, after showing administration, animal bone marrow hemopoietic function is enlivened, and has possessed better hematopoietic potential.The bone marrow depression of medicine to caused by cyclophosphamide creates reparation and facilitation.
Use DIYU SHENGBAI PIAN as positive control drug in this experiment, result shows, the present invention adds taste Chinese angelica blood supplementing side and is being better than positive control drug to chemotherapeutic myelosuppression animal model peripheral white blood cell lifting effect, on identical with positive drug effect in the affecting of bonemarrow nucleated cells number, in overall merit experimental group during dosed administration, the toxicity of chemotherapeutics to body can be alleviated, improve the quantity of leucocyte of peripheral blood in chemotherapy process, enhancing body bone marrow hematogenesis function, has certain reasonability with the use of invigorating qi and benefiting blood Chinese medicine in chemotherapy of tumors process.
This result of the test shows that the present invention adds the general body condition that taste Chinese angelica blood supplementing Chinese medicine obviously can improve caused by cyclophosphamide leukopenia mice, improve Mouse Weight rate of increase, raise peripheral white blood cell, improve immune organ spleen index, increase bone marrow nucleated cell percentage ratio, add taste Chinese angelica blood supplementing Chinese medicine and chemotherapeutic caused by cyclophosphamide leukopenia mice tool is improved significantly.
Detailed description of the invention
Embodiment 1
The Radix Astragali 30 g, Radix Angelicae Sinensis 9 g, Fructus Ligustri Lucidi 15 g, Fructus Lycii 15 g, Rhizoma Curculiginis 15 g, Herba Epimedii 15 g, Rhizoma Polygonati 9 g, Massa Medicata Fermentata (parched to brown) 15 g, Fructus Crataegi (parched to brown) 15 g, Fructus Hordei Germinatus (parched to brown) 15 g, Rhizoma Atractylodis Macrocephalae (parched) 15 g, Pericarpium Citri Reticulatae 9 g, Poria 9 g, Fructus Jujubae 3 g.14 taste crude drug are decocted with water secondary, each 1.5 hours, collecting decoction, filter, it is 1.25 ~ 1.30(60 DEG C that filtrate is condensed into relative density) clear paste; 70 DEG C of drying under reduced pressure, are ground into fine powder; Add dextrin mixing again, granulate; 60 DEG C of dryings, to obtain final product.
Embodiment 2
Radix Astragali 30g, Radix Angelicae Sinensis 10g, Fructus Ligustri Lucidi 15g, Fructus Lycii 15g, Rhizoma Curculiginis 15g, Herba Epimedii 15g, Rhizoma Polygonati 10g, Massa Medicata Fermentata (parched to brown) 15g, Fructus Crataegi (parched to brown) 15g, Fructus Hordei Germinatus (parched to brown) 15g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Pericarpium Citri Reticulatae 10g, Poria 10g, Fructus Jujubae 3g.After boiling extraction, water-bath concentrates, and makes granule.
Embodiment 3
The Radix Astragali 60 g, Radix Angelicae Sinensis 18 g, Fructus Ligustri Lucidi 24 g, Fructus Lycii 24 g, Rhizoma Curculiginis 24 g, Herba Epimedii 24 g, Rhizoma Polygonati 18 g, Massa Medicata Fermentata (parched to brown) 24 g, Fructus Crataegi (parched to brown) 24 g, Fructus Hordei Germinatus (parched to brown) 24 g, Rhizoma Atractylodis Macrocephalae (parched) 24 g, Pericarpium Citri Reticulatae 18 g, Poria 18 g, Fructus Jujubae 9 g.14 taste crude drug are decocted with water secondary, each 1.5 hours, collecting decoction, filter, it is 1.25 ~ 1.30(60 DEG C that filtrate is condensed into relative density) clear paste; 70 DEG C of drying under reduced pressure, are ground into fine powder; Add dextrin mixing again, granulate; 60 DEG C of dryings, to obtain final product.
Embodiment 4
The Radix Astragali 45 g, Radix Angelicae Sinensis 15g, Fructus Ligustri Lucidi 20 g, Fructus Lycii 18g, Rhizoma Curculiginis 22g, Herba Epimedii 20 g, Rhizoma Polygonati 15g, Massa Medicata Fermentata (parched to brown) 22g, Fructus Crataegi (parched to brown) 16 g, Fructus Hordei Germinatus (parched to brown) 20g, Rhizoma Atractylodis Macrocephalae (parched) 18 g, Pericarpium Citri Reticulatae 14g, Poria 12 g, Fructus Jujubae 6 g.14 taste crude drug are decocted with water secondary, each 1.5 hours, collecting decoction, filter, it is 1.25 ~ 1.30(60 DEG C that filtrate is condensed into relative density) clear paste; 70 DEG C of drying under reduced pressure, are ground into fine powder; Add dextrin mixing again, granulate; 60 DEG C of dryings, to obtain final product.
Claims (3)
1. can improve a compound Chinese medicinal preparation for hemopoietic function, it is characterized in that crude drug comprises: Radix Astragali 30-60 part, Radix Angelicae Sinensis 9-18 part, Fructus Ligustri Lucidi 15-24 part, Fructus Lycii 15-24 part, Rhizoma Curculiginis 15-24 part, Herba Epimedii 15-24 part, Rhizoma Polygonati 9-18 part, Massa Medicata Fermentata (parched to brown) 15-24 part, Fructus Crataegi (parched to brown) 15-24 part, Fructus Hordei Germinatus (parched to brown) 15-24 part, Rhizoma Atractylodis Macrocephalae (parched) 15-24 part, Pericarpium Citri Reticulatae 9-18 part, Poria 9-18 part, Fructus Jujubae 3-9 part.
2. preparation according to claim 1, is characterized in that crude drug comprises: the Radix Astragali 30 parts, Radix Angelicae Sinensis 10 parts, Fructus Ligustri Lucidi 15 parts, Fructus Lycii 15 parts, Rhizoma Curculiginis 15 parts, Herba Epimedii 15 parts, Rhizoma Polygonati 10 parts, Massa Medicata Fermentata (parched to brown) 15 parts, Fructus Crataegi (parched to brown) 15 parts, Fructus Hordei Germinatus (parched to brown) 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Pericarpium Citri Reticulatae 10 parts, 10 parts, Poria, 3 parts, Fructus Jujubae.
3. preparation according to claim 1 and 2, is characterized in that: during preparation, and 14 taste crude drug are decocted with water secondary, each 1.5 hours, collecting decoction, filter, it is 1.25 ~ 1.30(60 DEG C that filtrate is condensed into relative density) clear paste; 70 DEG C of drying under reduced pressure, are ground into fine powder; Add dextrin mixing again, granulate; 60 DEG C of dryings, to obtain final product.
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| Title |
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| 杨喜花等: "加味当归补血中药对环磷酰胺所致小鼠白细胞减少的影响", 《中国药物与临床》 * |
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