CN104825803A - Traditional Chinese patent medicine preparation for treating prostate diseases and preparation method thereof - Google Patents
Traditional Chinese patent medicine preparation for treating prostate diseases and preparation method thereof Download PDFInfo
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- CN104825803A CN104825803A CN201410047119.4A CN201410047119A CN104825803A CN 104825803 A CN104825803 A CN 104825803A CN 201410047119 A CN201410047119 A CN 201410047119A CN 104825803 A CN104825803 A CN 104825803A
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Abstract
The invention aims to provide a traditional Chinese patent medicine preparation for treating prostate diseases and a preparation method thereof. The invention solves a technical problem of preparing a medicine for soothing urine retention for treating the prostate diseases into a paste preparation to improve bioavailability of the medicine for soothing urine retention. The invention, to solve the technical problem, provides a technical scheme in which the traditional Chinese patent medicine preparation for treating the prostate diseases comprises following components, by weight: 10-20 parts of golden amber, 400-480 parts of psoralea corylifolia, 300-400 parts of leonurus artemisia, 420-480 parts of lysimachia christinae, 460-520 parts of lygodium japonicum and 200-250 parts of iphigenia indica.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine preparation for the treatment of prostatosis and preparation method thereof.
Background technology
Prostatitis, prostatic hyperplasia, prostate hyperplasia and urinary tract infection, it is clinical common frdquently encountered disease, especially middle-older patient is because of prostatic hyperplasia or loose and urinating of causing is smooth, urine thin, oliguria, urine are waited for, it is unable etc. painful abnormal to urinate, and has a strong impact on patient's physically and mentally healthy and quality of life.The traditional Chinese medical science claims prostatosis to be " stranguria ", " turbid urine ", " difficulty in urination ".
At present, LONGBISHU preparation is widely used in the treatment of prostatosis clinically, LONGBISHU preparation is made up of golden amber and blue Herba Amaranthi tricoloris, Flos Carthami Chinese mugwort, Herba Lysimachiae, Spora Lygodii, hair Rhizoma sagittariae sagittifoliae, has the functions such as the kidney warming activating QI, relieving stranguria by diuresis, blood circulation promoting and blood stasis dispelling, removing obstruction for relieving pain.Clinical research proves that LONGBISHU is to the treatment effective and safe of prostatosis, is applicable to long-term taking.At present, the LONGBISHU preparation of Clinical practice based on capsule and tablet, because tablet, capsule also exist the problems such as bioavailability is low, onset is slow.Therefore, we need a kind of bioavailability is better, curative effect is higher LONGBISHU preparation to meet the demand of clinical application.
Summary of the invention
The object of the invention is to, a kind of Chinese patent medicine preparation for the treatment of prostatosis and preparation method thereof is provided.The technical problem solved is that the LONGBISHU formula for the treatment of prostatosis is prepared into ointment preparation, improves the bioavailability of LONGBISHU.
For solving the problems of the technologies described above, the invention provides following technical scheme:
Treat a Chinese patent medicine preparation for prostatosis, it is characterized in that it comprises the material medicine of following weight proportion: Jin Po 10-20 part, and blue Herba Amaranthi tricoloris 400-480 part, Flos Carthami Chinese mugwort 300-400 part, Herba Lysimachiae 420-480 part, Spora Lygodii 460-520 part, hair Rhizoma sagittariae sagittifoliae 200-250 part.
Preferably, its dosage form is oral Chinese medicine preparation, and consumption is 20-40g every day.
Preferably, raw material used and weight proportion thereof are: Jin Po 15 parts, and blue Herba Amaranthi tricoloris 450 parts, and Flos Carthami ends 350 parts, Herba Lysimachiae 460 parts, Spora Lygodii 480 parts, hair Rhizoma sagittariae sagittifoliae 230 parts.
The dosage form of above-mentioned raw materials and weight proportion thereof is oral Chinese medicinal ointment, and consumption is 30-50g every day.
The present invention also provides a kind of preparation method for the treatment of the Chinese patent medicine preparation of prostatosis, specifically comprises the steps:
Step 1, get clean with blue Herba Amaranthi tricoloris, Flos Carthami Chinese mugwort, Herba Lysimachiae, Spora Lygodii, hair Rhizoma sagittariae sagittifoliae soak by water 2-4 time, each 1-3 hour, merges decoction liquor, filtration, filtrate is condensed into clear paste A;
Step 2, gets clean golden amber and is ground into fine powder B;
Step 3, merges the clear paste A of above-mentioned preparation and fine powder B and pours in container, add 3-6 times amount warm water and run through and dissolve, and by lysate ebuillition of heated after 5-10 minute, adds Mel and/or the brown sugar of the heavy 0.1-0.5 times amount of recipe quantity;
Step 4, keeps slight boiling condition, adds strong mixing, prevents from gluing pot when receiving cream, is 1.2-1.5 to mastic thickness, relative density, receives cream packaging.
Preferably, also can add Colla Corii Asini or Carapax et Plastrum Testudinis cream in step 3 in above-mentioned preparation method, detailed process is: after described lysate being heated to boiling, adds Colla Corii Asini or the Carapax et Plastrum Testudinis cream of the heavy 0.05-0.1 times amount of recipe quantity; After dissolving, boiling adds Mel or the brown sugar of the heavy 0.1-0.5 times amount of recipe quantity for 5-10 minute again.
Preferably, the Mel added in described step 3 is Flos Sophorae Mel.
Preferably, in described step 4, before receiving cream packaging, mastic is made granule, and adding powder percentage by weight after granulate is the adsorbent of 0.3%-1%, the lubricant of 1%-3%, mixing; Adsorbent is one or more in microcrystalline Cellulose, starch, calcium carbonate, kieselguhr and micropowder silica gel; Lubricant is any one or a few in magnesium stearate, micropowder silica gel, Pulvis Talci.
Preferably, in described step 2, Jin Po pulverizes and adopts the mode of cell wall breaking to carry out Chinese medicine superfine grinding, and after pulverizing, finished product grain size controls at 2-3 μm, and medicine yield is 94-98.8%.
Compared with prior art, beneficial effect of the present invention is as follows:
1, in the present invention, the Chinese patent medicine preparation component for the treatment of prostatosis is prepared into unguentum, relative to Tablet and Capsula, be easier to absorption of human body, rapid-action, bioavailability is high.
2, in the preparation process of unguentum, add Mel and/or brown sugar, make the mouthfeel of unguentum better on the one hand; Contain zinc in brown sugar on the other hand, the infection function of prostate surrounding tissue can be increased, containing multivitamin in Mel, contribute to repairing prostate.
Detailed description of the invention
Below in conjunction with detailed description of the invention, embodiment of the present invention are described in detail.
Embodiment 1
Treat a preparation method for the Chinese patent medicine preparation of prostatosis, comprise the steps:
(1) get clean with blue Herba Amaranthi tricoloris 400g, Flos Carthami Chinese mugwort 300g, Herba Lysimachiae 420g, Spora Lygodii 460g, hair Rhizoma sagittariae sagittifoliae 200g soak by water 2 times, each 3 hours, merge decoction liquor, filtration, filtrate be condensed into clear paste A; Get clean golden amber 10g and be ground into fine powder B;
(2) the clear paste A of above-mentioned preparation and fine powder B merging is poured in container, add 3 times amount warm waters and run through and dissolve, by lysate ebuillition of heated after 5 minutes, add the Mel that recipe quantity weighs 0.1 times amount; Keep slight boiling condition, add strong mixing, preventing from gluing pot when receiving cream, is 1.2 to mastic thickness, relative density, receives cream packaging.
In the present embodiment, also can add Colla Corii Asini or Carapax et Plastrum Testudinis cream as required, detailed process is: get recipe quantity and weigh 0.05 times amount (89.5g) Colla Corii Asini or Carapax et Plastrum Testudinis cream, after yellow wine molten, adds in the lysate of above-mentioned clear paste A and fine powder B; Dissolving rear boiling adds recipe quantity for 5-10 minute again and weighs 0.1 times amount (179g) Mel or brown sugar.
In described step 4, before receiving cream packaging, mastic is made granule, and adding powder percentage by weight after granulate is the adsorbent of 0.3%-1%, the lubricant of 1%-3%, mixing; Adsorbent is one or more in microcrystalline Cellulose, starch, calcium carbonate, kieselguhr and micropowder silica gel; Lubricant is any one or a few in magnesium stearate, micropowder silica gel, Pulvis Talci.
In described step 2, Jin Po pulverizes and adopts the mode of cell wall breaking to carry out Chinese medicine superfine grinding, and after pulverizing, finished product grain size controls at 2-3 μm, and medicine yield is 94-98.8%.
The medicament of the prostatosis adopting said components content to prepare, its scope of getting it filled rationally gets the weight percentage of determining monarch, minister and part adjuvant drug, enhances the curative effect of medicament, in clinical trial, makes the cure rate of effective crowd reach 70-78 parts.
Embodiment 2
Treat a preparation method for the Chinese patent medicine preparation of prostatosis, comprise the steps:
(1) get clean with blue Herba Amaranthi tricoloris 480g, Flos Carthami Chinese mugwort 400g, Herba Lysimachiae 480g, Spora Lygodii 520g, hair Rhizoma sagittariae sagittifoliae 250g soak by water 4 times, each 1 hour, merge decoction liquor, filtration, filtrate be condensed into clear paste A; Get clean golden amber 20g and be ground into fine powder B;
(2) the clear paste A of above-mentioned preparation and fine powder B merging is poured in container, add 6 times amount warm waters and run through and dissolve, by lysate ebuillition of heated after 10 minutes, add the brown sugar that recipe quantity weighs 0.5 times amount; Keep slight boiling condition, add strong mixing, preventing from gluing pot when receiving cream, is 1.5 to mastic thickness, relative density, receives cream packaging.
In the present embodiment, also can add Colla Corii Asini or Carapax et Plastrum Testudinis cream as required, detailed process is: get Colla Corii Asini or Carapax et Plastrum Testudinis cream that described recipe quantity weighs 0.1 times amount (215g), after yellow wine molten, adds in the lysate of above-mentioned clear paste A and fine powder B; After dissolving, boiling adds the heavy 0.5(1085g of recipe quantity for 5-10 minute again) Mel of times amount or brown sugar.
In described step 4, before receiving cream packaging, mastic is made granule, and adding powder percentage by weight after granulate is the adsorbent of 0.3%-1%, the lubricant of 1%-3%, mixing; Adsorbent is one or more in microcrystalline Cellulose, starch, calcium carbonate, kieselguhr and micropowder silica gel; Lubricant is any one or a few in magnesium stearate, micropowder silica gel, Pulvis Talci.
In described step 2, Jin Po pulverizes and adopts the mode of cell wall breaking to carry out Chinese medicine superfine grinding, and after pulverizing, finished product grain size controls at 2-3 μm, and medicine yield is 96.2%.
Caused by the difficulty in urination that prescription unguentum prepared by this implementation method significantly can alleviate dampness and heat stasis, frequent micturition, urgent micturition, dark coloured urine, dysurea, urine thin are as line, lower abdomen contracture pain, the diseases such as soreness of the waist and knees, and clinical effective rate reaches 91 parts; In clinical experiment, after several patient consumes 1-3 course for the treatment of, lower abdomen contracture pain symptom is alleviated greatly, and after continuous clothes, muscle power is cumulative, and the diseases such as soreness of the waist and knees are gradually delayed, and period does not find Relapse rate and other untoward reaction and side effect.
Embodiment 3
Treat a preparation method for the Chinese patent medicine preparation of prostatosis, comprise the steps:
(1) get clean with blue Herba Amaranthi tricoloris 450g, Flos Carthami Chinese mugwort 350g, Herba Lysimachiae 460g, Spora Lygodii 480g, hair Rhizoma sagittariae sagittifoliae 230g soak by water 3 times, each 2 hours, merge decoction liquor, filtration, filtrate be condensed into clear paste A; Get clean golden amber 15g and be ground into fine powder B;
(2) the clear paste A of above-mentioned preparation and fine powder B are merged pour in container, add 4 times amount warm waters and run through and dissolve, by lysate ebuillition of heated after 8 minutes, add recipe quantity and weigh the brown sugar that the Mel of 0.15 times amount and recipe quantity weigh 0.15 times amount; Keep slight boiling condition, add strong mixing, preventing from gluing pot when receiving cream, is 1.3 to mastic thickness, relative density, receives cream packaging.
In the present embodiment, also can add Colla Corii Asini or Carapax et Plastrum Testudinis cream as required, detailed process is: get Colla Corii Asini or Carapax et Plastrum Testudinis cream that described recipe quantity weighs 0.08 times amount (158.8g), after yellow wine molten, adds in the lysate of above-mentioned clear paste A and fine powder B; After dissolving, boiling adds Mel or the brown sugar that recipe quantity weighs 0.3 times amount (595.5g) for 5-10 minute again.
In described step 4, before receiving cream packaging, mastic is made granule, and adding powder percentage by weight after granulate is the adsorbent of 0.3%-1%, the lubricant of 1%-3%, mixing; Adsorbent is one or more in microcrystalline Cellulose, starch, calcium carbonate, kieselguhr and micropowder silica gel; Lubricant is any one or a few in magnesium stearate, micropowder silica gel, Pulvis Talci.
In described step 2, Jin Po pulverizes and adopts the mode of cell wall breaking to carry out Chinese medicine superfine grinding, and after pulverizing, finished product grain size controls at 2-3 μm, and medicine yield is 98.8%.
In the present embodiment, getting with blue Herba Amaranthi tricoloris 450g is monarch drug, and obvious coronary vasodilation, can strengthen myocardial contraction, and 350g Flos Carthami Chinese mugwort is ministerial drug, and low dose can make intestinal tube tonicity relax, and amplitude expands, and heavy dose then acts on the contrary; Have the effect of anticoagulant, 230g hair Rhizoma sagittariae sagittifoliae is adjuvant drug, strengthens hypnotic effect, suppresses the effect such as respiratory center, raising blood pressure.
Proportioning of its composition, can maximum enhancing the kidney warming activating QI in clinical trial, clearing heat and freeing strangury, blood circulation promoting and blood stasis dispelling, effect of removing obstruction for relieving pain, then is equipped with 20g gold amber and gets its diuresis and sedation, also has certain optimum effect for nocturia frequency, look agitation.
In clinical trial, medical effect of the present invention can be found out by following data:
Be more than the description of this invention and non-limiting, based on other embodiment of inventive concept, all among protection scope of the present invention.
Claims (10)
1. treat a Chinese patent medicine preparation for prostatosis, it is characterized in that it comprises the material medicine of following weight proportion:
Gold amber 10-20 part, and blue Herba Amaranthi tricoloris 400-480 part, Flos Carthami Chinese mugwort 300-400 part, Herba Lysimachiae 420-480 part, Spora Lygodii 460-520 part, hair Rhizoma sagittariae sagittifoliae 200-250 part.
2. treat the Chinese patent medicine preparation of prostatosis as claimed in claim 1, it is characterized in that, its dosage form is oral Chinese medicine preparation.
3. treat the Chinese patent medicine preparation of prostatosis as claimed in claim 1, it is characterized in that raw material used and weight proportion thereof are:
Gold amber 15 parts, and blue Herba Amaranthi tricoloris 450 parts, Flos Carthami ends 350 parts, Herba Lysimachiae 460 parts, Spora Lygodii 480 parts, hair Rhizoma sagittariae sagittifoliae 230 parts.
4. treat the Chinese patent medicine preparation of prostatosis as claimed in claim 3, it is characterized in that, its dosage form is oral Chinese medicinal ointment.
5. the Chinese patent medicine preparation for the treatment of prostatosis as claimed in claim 3, is characterized in that: the consumption of the Chinese medicinal ointment of described treatment prostatosis is 30-50g every day.
6. the preparation method of the Chinese patent medicine preparation of the treatment prostatosis as described in any one of claim 1-5, is characterized in that: comprise the steps:
Step 1, get clean with blue Herba Amaranthi tricoloris, Flos Carthami Chinese mugwort, Herba Lysimachiae, Spora Lygodii, hair Rhizoma sagittariae sagittifoliae soak by water 2-4 time, each 1-3 hour, merges decoction liquor, filtration, filtrate is condensed into clear paste A;
Step 2, gets clean golden amber and is ground into fine powder B;
Step 3, merges the clear paste A of above-mentioned preparation and fine powder B and pours in container, add 3-6 times amount warm water and run through and dissolve, and by lysate ebuillition of heated after 5-10 minute, adds Mel and/or the brown sugar of the heavy 0.1-0.5 times amount of recipe quantity;
Step 4, keeps slight boiling condition, adds strong mixing, prevents from gluing pot when receiving cream, is 1.2-1.5 to mastic thickness, relative density, receives cream packaging.
7. the preparation method of the Chinese patent medicine preparation for the treatment of prostatosis as claimed in claim 6, is characterized in that: described step 3 also comprises,
In the lysate of aforementioned clear paste A and fine powder B, add Colla Corii Asini or the Carapax et Plastrum Testudinis cream of the heavy 0.05-0.1 times amount of recipe quantity; After dissolving, boiling adds Mel or the brown sugar of the heavy 0.1-0.5 times amount of recipe quantity for 5-10 minute again.
8. the preparation method of the Chinese patent medicine preparation for the treatment of prostatosis as claimed in claim 6, is characterized in that: the Mel added in described step 3 is Flos Sophorae Mel.
9. the preparation method of the Chinese patent medicine preparation for the treatment of prostatosis as claimed in claim 6, it is characterized in that: in described step 4, before receiving cream packaging, mastic is made granule, adding powder percentage by weight after granulate is the adsorbent of 0.3%-1%, the lubricant of 1%-3%, mixing; Adsorbent is one or more in microcrystalline Cellulose, starch, calcium carbonate, kieselguhr and micropowder silica gel; Lubricant is any one or a few in magnesium stearate, micropowder silica gel, Pulvis Talci.
10. the preparation method of the Chinese patent medicine preparation for the treatment of prostatosis as claimed in claim 6, it is characterized in that: in described step 2, Jin Po pulverizes and adopts the mode of cell wall breaking to carry out Chinese medicine superfine grinding, and after pulverizing, finished product grain size controls at 2-3 μm, and medicine yield is 94-98.8%.
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| CN201410047119.4A CN104825803A (en) | 2014-02-11 | 2014-02-11 | Traditional Chinese patent medicine preparation for treating prostate diseases and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152450A (en) * | 2007-10-10 | 2008-04-02 | 天津药业集团新郑股份有限公司 | Dysuria releasing tablet and method for preparing the same |
| CN101816749A (en) * | 2010-05-01 | 2010-09-01 | 秦皇岛皇威制药有限公司 | Medicament for curing dysuria, preparation method and quality control method thereof |
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- 2014-02-11 CN CN201410047119.4A patent/CN104825803A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152450A (en) * | 2007-10-10 | 2008-04-02 | 天津药业集团新郑股份有限公司 | Dysuria releasing tablet and method for preparing the same |
| CN101816749A (en) * | 2010-05-01 | 2010-09-01 | 秦皇岛皇威制药有限公司 | Medicament for curing dysuria, preparation method and quality control method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 庞国明等: "《膏方临床应用指南》", 31 January 2012 * |
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Application publication date: 20150812 |
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