CN104825597A - Traditional Chinese medicine composition for treating chronic cholecystitis and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic cholecystitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials by weight: maidenhair, ludwigia octovalvis herb, lepisorus scolopendrium, erigeron canadensis L., lip-fern, fruticulos moghania, halfspreading ironweed herb, coriaceous knotweed rhizome, raspberry leaves, peltateleaf meadowrue herb or root, entireleaf neoalsomitra, foxtail-like sophora root, boxleaf atalantia root, tirpitzia ovoidea, sibirica walking fern herb, Pemisetum flaccidum Griseb., blin conyza herb, broussonetia kazinoki, suchow mosla herb, medicinal kopsia fruit and leaves, neopallasia pectinata, Ficus gibbosa Blume, liliaceae peliosanthes macrophylla and scarlet swertia herb. The traditional Chinese medicine composition is developed on the basis of traditional Chinese medicine dialectical treatment in combination with clinical tests, has the efficacies of clearing heat, promoting diuresis, clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, diminishing inflammation, relieving pain and dispersing stagnated liver qi to promote bile flow and has the characteristics of high clinical cure rate, safety, convenience and no toxic and side effects.

Description

A kind of Chinese medicine composition for the treatment of chronic cholecystitis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of chronic cholecystitis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Chronic cholecystitis is Clinical Surgery's commonly encountered diseases, frequently-occurring disease.Chronic cholecystitis often shows as right upper quadrant of the abdomen dull pain clinically, and painful abdominal mass is swollen does not relax, indigestion and loss of appetite, abdominal distention, belch, the symptoms such as loose stool.During actute infection outbreak, anxious endanger complication, the even threat to life such as serious symptom biliary tract infection, Biliary pancreatitis, septic shock can be caused.Along with the raising of people's living standard and the change of dietary habit, and the increase of operating pressure, this disease have the trend risen year by year, it seriously affects the healthy of people and life.The sickness rate of primary disease has the trend risen year by year.It is long that this disease has the course of disease, the feature of easy recurrent exerbation, at present treatment primary disease many employings anti-inflammatory and choleretic class medicine, as XIAOYAN LIDAN PIAN, disappear bladder, but effect is all undesirable, and this disease of western medical treatment does not also have desirable medicine, there is the shortcomings such as side effect is more, expensive.Applicant of the present invention proves through clinical practice for many years, utilizes treatment by Chinese herbs chronic cholecystitis to have good effect, the advantage that side effect is little.

Primary disease belong to the traditional Chinese medical science " hypochondriac pain ", " abdominal distention ", " gallbladder-distention ", etc. the category of disease.Its cause of disease is mainly the many factors such as feelings will is unsuccessful, eating and drinking without temperance, injury from falling down, weakness due to chronic disease, causes depression of liver-QI, and liver is lost bar and reaches; Congestion is at a stop, numbness resistance side of body network; Damp-heat accumulation, the liver failing to maintain the normal flow of QI; Deficiecny of liver-YIN, channels loses many changes such as supporting, finally causes hypochondriac pain to occur; With qi depression to blood stasis, channels loses and supports as main pathogenesis.Because the primary disease course of disease is long, recurrent exerbation and protracted course of disease, the traditional Chinese medical science adopts determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs to treat, often with soothing the liver and network pain relieving for the rule for the treatment of, and in conjunction with the feature of liver and gall, give reasonable utilization.Because disease has void to have reality, and common with excess syndrome, and can mutually transform between deficiency and excess, therefore clinical normal common with the card of simulataneous insufficiency and excessive, this just requires that each pattern of syndrome with card plus-minus, should can reach its effect when treating; For the hypochondriac pain of excess syndrome, should with regulating the flow of vital energy, invigorate blood circulation, the method for eliminating damp-heat; The hypochondriac pain of deficiency syndrome, should invigorating middle warmer residence logical, adopt YIN nourishing, nourish blood, the method for easing the affected liver.

The present invention provides a kind of Chinese medicine composition being used for the treatment of chronic cholecystitis on the basis of theory of Chinese medical science and clinical practice, and relative to Western medicine, it has good effect, safety and the advantage of the secondary little effect of poison.

Summary of the invention

The object of this invention is to provide Chinese medicine composition of a kind of more efficiently treatment chronic cholecystitis and preparation method thereof.

Chinese medicine composition prescription of the present invention composition be through inventor through clinical experience for many years, grope to sum up out prescription evident in efficacy.We select Herba Adianti Flabellulati, Ludwigia octovalvis (Jacq.) Raven, concave tile Wei, Conyza canadensis (L.) Cronq., Herba Cheilanthes chusane, concha Anodonta seu Cristaria medical herbs material to carry out combination and compatibility, and Herba Adianti Flabellulati can clearing away heat-damp and promoting diuresis, blood stasis slaking and dissipating edema.Ludwigia octovalvis (Jacq.) Raven, clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating.Concave tile Wei, clearing away heat-damp and promoting diuresis.Conyza canadensis (L.) Cronq., clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling.Herba Cheilanthes chusane, clearing away heat-damp and promoting diuresis, removing toxic substances.Concha Anodonta seu Cristaria grass, dehumidifying of bringing down a fever, disappear infantile malnutrition, cough-relieving.We are made to have effect of clearing away heat-damp and promoting diuresis.We are compatibility Herba Vernoniae Patulae, Rhizoma Polygoni coriacei, Herba pronephrii triphylli, Herba Thalictri Ichangensis, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Sophorae Alopecuroidis medical material again, selects Herba Vernoniae Patulae can fresh breeze heat clearing away, eliminating damp, detoxifying, dissipating blood stasis for subsidence of swelling.Rhizoma Polygoni coriacei, heat-clearing and toxic substances removing.Herba pronephrii triphylli, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, preventing phlegm from forming and stopping coughing.Herba Thalictri Ichangensis, heat-clearing and toxic substances removing, dampness.Neoalsomitra integrifoliola (Cogn.) Hucth., heat-clearing and toxic substances removing, pain relieving.Radix Sophorae Alopecuroidis, heat-clearing and toxic substances removing.We are made to have effect of heat-clearing and toxic substances removing.

We again compatibility Radix Atalantiae Buxifoliae, spend bavin, Herba Camptosori Sibirici, root of Pennisetum centrasiaticum Tzvel., Herba conyzae blinii, paddy skin rattan medical material in vain, select Radix Atalantiae Buxifoliae energy, stasis-dispelling and pain-killing, pleasantly to reduce phlegm.Spend bavin in vain, promoting blood circulation to remove blood stasis, relaxing muscles and tendons and activating QI and blood in the collateral.Herba Camptosori Sibirici, blood circulation promoting and blood stasis dispelling, hemostasis removing toxic substances.Root of Pennisetum centrasiaticum Tzvel., clearing away heat and cooling blood, diuresis.Herba conyzae blinii, heat-clearing and toxic substances removing, pathogenic fire purging is stopped blooding.Paddy skin rattan, clearing away heat and promoting diuresis, promoting blood circulation and detumescence.We are made to have effect of blood circulation promoting and blood stasis dispelling.

Last compatibility Herba Moslae Soochowensis again, Fructus Seu Folium Kopsiae Officinalis, comb leaf Artemisia, Dou leaf banyan, Aranea grass, Herba Swertiae Puniceae medical material, select Herba Moslae Soochowensis can detoxicating, relieving inflammation, promoting diuresis and easing pain.Fructus Seu Folium Kopsiae Officinalis, anti-inflammatory analgetic, relaxing muscles and tendons and activating QI and blood in the collateral.Comb leaf Artemisia, clearing liver-gallbladder, anti-inflammatory analgetic.Dou leaf banyan, heat clearing away, antiinflammatory, spasmolytic.Aranea grass, expelling phlegm for arresting cough, Shugan Zhitong.Herba Swertiae Puniceae, liver heat removing function of gallbladder promoting, heat-clearing and toxic substances removing, dampness removing.We are made to have anti-inflammatory analgetic, effect of depressed liver-energy dispersing and function of gallbladder promoting.

The all medicines of full side share, and liver and gall mechanism of qi can be made unobstructed, clearing moist heat, blood stasis disappear, stomachache stops, and all cards are separated.Clinical effectiveness is remarkable.Full side is made to play effect of clearing away heat-damp and promoting diuresis, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, depressed liver-energy dispersing and function of gallbladder promoting altogether, and the effect to chronic cholecystitis patient Ke Da treating both the principal and secondary aspects of a disease.

The consumption of Chinese medicine composition of the present invention is also through to grope in a large number to sum up and draws, and each amounts of components all has good curative effect in following weight parts scope.

It is made up of the crude drug of following weight portion: Herba Adianti Flabellulati 36 ~ 40 parts, Ludwigia octovalvis (Jacq.) Raven 36 ~ 40 parts, concave tile Wei 30 ~ 34 parts, Conyza canadensis (L.) Cronq. 18 ~ 22 parts, Herba Cheilanthes chusane 23 ~ 27 parts, concha Anodonta seu Cristaria grass 23 ~ 27 parts, Herba Vernoniae Patulae 18 ~ 22 parts, Rhizoma Polygoni coriacei 16 ~ 20 parts, Folium Rubi 16 ~ 20 parts, Herba Thalictri Ichangensis 11 ~ 15 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 16 ~ 20 parts, Radix Sophorae Alopecuroidis 14 ~ 18 parts, Radix Atalantiae Buxifoliae 10 ~ 14 parts, spend bavin 10 ~ 14 parts in vain, Herba Camptosori Sibirici 13 ~ 17 parts, root of Pennisetum centrasiaticum Tzvel. 13 ~ 17 parts, Herba conyzae blinii 7 ~ 11 parts, 8 ~ 12 parts, paddy skin rattan, Herba Moslae Soochowensis 8 ~ 12 parts, Fructus Seu Folium Kopsiae Officinalis 12 ~ 16 parts, comb leaf Artemisia 11 ~ 15 parts, Dou leaf banyan 6 ~ 10 parts, Aranea grass 4 ~ 8 parts, 4 ~ 8 parts, Herba Swertiae Puniceae,

Preparation method is as follows:

(1), by Radix Atalantiae Buxifoliae, paddy skin rattan, the mixing of Fructus Seu Folium Kopsiae Officinalis medical material, 50 DEG C of dry 3h, are ground into 100 order fine powders, for subsequent use;

(2) get Herba Cheilanthes chusane, root of Pennisetum centrasiaticum Tzvel., Dou leaf banyan be ground into coarse powder, infiltrate with 70% ethanol, adding medical material weight ratio is that 8 times amount 70% ethanol carry out percolation, collects percolate, decompression recycling ethanol, and after concentrated, drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;

(3) by Herba Adianti Flabellulati, Ludwigia octovalvis (Jacq.) Raven, concave tile Wei, Conyza canadensis (L.) Cronq., concha Anodonta seu Cristaria grass, Herba Vernoniae Patulae, Rhizoma Polygoni coriacei, Folium Rubi, Herba Thalictri Ichangensis, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Sophorae Alopecuroidis, spend bavin in vain, Herba Camptosori Sibirici, Herba conyzae blinii, Herba Moslae Soochowensis, comb leaf Artemisia, Aranea grass, Herba Swertiae Puniceae medical material merges, it is the water of 10 times amount that first time adds with medical material weight ratio, decocting time 1h, it is the water of 8 times amount that second time adds with medical material weight ratio, decocting time 1h, filter, merge twice filtrate, filtrate reduced in volume becomes relative density 1.05 ~ 1.10 clear paste, adding ethanol makes determining alcohol reach 65%, cold preservation leaves standstill 24h, filter, filtrate becomes dried cream powder through drying under reduced pressure, sieve, for subsequent use,

By above-mentioned (1) in fine powder for subsequent use and (2) and (3) in dried cream powder for subsequent use, after mixing, to obtain final product, the active component of Chinese medicine composition of the present invention.

As preferably of the present invention, it is made up of the crude drug of following weight portion: Herba Adianti Flabellulati 38 parts, Ludwigia octovalvis (Jacq.) Raven 38 parts, concave tile Wei 32 parts, Conyza canadensis (L.) Cronq. 20 parts, Herba Cheilanthes chusane 25 parts, concha Anodonta seu Cristaria grass 25 parts, Herba Vernoniae Patulae 20 parts, Rhizoma Polygoni coriacei 18 parts, Folium Rubi 18 parts, Herba Thalictri Ichangensis 13 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 18 parts, Radix Sophorae Alopecuroidis 16 parts, Radix Atalantiae Buxifoliae 12 parts, spend in vain bavin 12 parts, Herba Camptosori Sibirici 15 parts, root of Pennisetum centrasiaticum Tzvel. 15 parts, Herba conyzae blinii 9 parts, 10 parts, paddy skin rattan, Herba Moslae Soochowensis 10 parts, Fructus Seu Folium Kopsiae Officinalis 14 parts, comb leaf Artemisia 13 parts, Dou leaf banyan 8 parts, Aranea grass 6 parts, 6 parts, Herba Swertiae Puniceae.

Preferably, the preparation method of Chinese medicine composition of the present invention, it is prepared from by with following processing step: (1) by Radix Atalantiae Buxifoliae, paddy skin rattan, the mixing of Fructus Seu Folium Kopsiae Officinalis medical material, 50 DEG C of dry 3h, are ground into 100 order fine powders, for subsequent use;

(2) get Herba Cheilanthes chusane, root of Pennisetum centrasiaticum Tzvel., Dou leaf banyan be ground into coarse powder, infiltrate with 70% ethanol, adding medical material weight ratio is that 8 times amount 70% ethanol carry out percolation, collects percolate, decompression recycling ethanol, and after concentrated, drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;

(3) by Herba Adianti Flabellulati, Ludwigia octovalvis (Jacq.) Raven, concave tile Wei, Conyza canadensis (L.) Cronq., concha Anodonta seu Cristaria grass, Herba Vernoniae Patulae, Rhizoma Polygoni coriacei, Folium Rubi, Herba Thalictri Ichangensis, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Sophorae Alopecuroidis, spend bavin in vain, Herba Camptosori Sibirici, Herba conyzae blinii, Herba Moslae Soochowensis, comb leaf Artemisia, Aranea grass, Herba Swertiae Puniceae medical material merges, it is the water of 10 times amount that first time adds with medical material weight ratio, decocting time 1h, it is the water of 8 times amount that second time adds with medical material weight ratio, decocting time 1h, filter, merge twice filtrate, filtrate reduced in volume becomes relative density 1.05 ~ 1.10 clear paste, adding ethanol makes determining alcohol reach 65%, cold preservation leaves standstill 24h, filter, filtrate becomes dried cream powder through drying under reduced pressure, sieve, for subsequent use,

By above-mentioned (1) in fine powder for subsequent use and (2) and (3) in dried cream powder for subsequent use, after mixing, to obtain final product, the active component of Chinese medicine composition of the present invention.

The active component of Chinese medicine composition of the present invention can add the adjuvant of the various routines prepared needed for different dosage form, as disintegrating agent, lubricant, filler, binding agent etc. are prepared into the conventional peroral dosage form of any one, as granule, tablet, hard capsule etc. with the Chinese medicine composition method of routine.

The present invention is under Traditional Chinese medical theory and clinical experience instruct, and through dialectical compatibility, chooses each crude drug component and proportioning thereof.Its each medical material compatibility complements each other using, and has synergism.To adapt to the treatment requirement of the complicated state of an illness, and improve the curative effect of full side.Through clinical verification, the effective percentage of the clinical cure of Chinese medicine composition of the present invention is 97.3%, and it is secret that it can promote that bile divides, and strengthens gallbladder contraction; Sphincter muscle of bile duct is relaxed, accelerates bile secretion.And have side effect little and more after the advantage that do not recur, and the preparation technology of Chinese medicine composition of the present invention is simple, and cost is low, has good market application foreground.The preparation method of product eliminates much useless flow process, simple and efficient, simultaneously can effect of maximum retained product.

Set forth the beneficial effect of Chinese medicine composition of the present invention further below by way of test example, these test examples comprise the clinical observation on the therapeutic effect test of Chinese medicine composition of the present invention.

Detailed description of the invention

Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.

The capsule preparation of embodiment 1 Chinese medicine composition of the present invention

(1), by Radix Atalantiae Buxifoliae 12g, paddy skin rattan 10g, the mixing of Fructus Seu Folium Kopsiae Officinalis 14g medical material, 50 DEG C of dry 3h, are ground into 100 order fine powders, for subsequent use;

(2) get Herba Cheilanthes chusane 25g, root of Pennisetum centrasiaticum Tzvel. 15g, Dou leaf banyan 8g is ground into coarse powder, infiltrate with 70% ethanol, adding medical material weight ratio is that 8 times amount 70% ethanol carry out percolation, collect percolate, decompression recycling ethanol, after concentrated, drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;

(3) by Herba Adianti Flabellulati 38g, Ludwigia octovalvis (Jacq.) Raven 38g, concave tile Wei 32g, Conyza canadensis (L.) Cronq. 20g, concha Anodonta seu Cristaria grass 25g, Herba Vernoniae Patulae 20g, Rhizoma Polygoni coriacei 18g, Folium Rubi 18g, Herba Thalictri Ichangensis 13g, Neoalsomitra integrifoliola (Cogn.) Hucth. 18g, Radix Sophorae Alopecuroidis 16g, spend bavin 12g in vain, Herba Camptosori Sibirici 15g, Herba conyzae blinii 9g, Herba Moslae Soochowensis 10g, comb leaf Artemisia 13g, Aranea grass 6g, Herba Swertiae Puniceae 6g medical material merges, it is the water of 10 times amount that first time adds with medical material weight ratio, decocting time 1h, it is the water of 8 times amount that second time adds with medical material weight ratio, decocting time 1h, filter, merge twice filtrate, filtrate reduced in volume becomes relative density 1.05 ~ 1.10 clear paste, adding ethanol makes determining alcohol reach 65%, cold preservation leaves standstill 24h, filter, filtrate becomes dried cream powder through drying under reduced pressure, sieve, for subsequent use,

By above-mentioned (1) in fine powder for subsequent use and (2) and (3) in dried cream powder for subsequent use, after mixing, to obtain final product, the active component of Chinese medicine composition of the present invention, to add suitable adjuvant, to granulate, encapsulated, make hard capsule.

The granule preparation of embodiment 2 Chinese medicine composition of the present invention

(1), by Radix Atalantiae Buxifoliae 10g, paddy skin rattan 12g, the mixing of Fructus Seu Folium Kopsiae Officinalis 16g medical material, 50 DEG C of dry 3h, are ground into 100 order fine powders, for subsequent use;

(2) get Herba Cheilanthes chusane 23g, root of Pennisetum centrasiaticum Tzvel. 17g, Dou leaf banyan 10g is ground into coarse powder, adding 70% ethanol and infiltrate, is that 8 times amount 70% ethanol carry out percolation by medical material weight ratio, collect percolate, decompression recycling ethanol, after concentrated, drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;

(3) by Herba Adianti Flabellulati 40g, Ludwigia octovalvis (Jacq.) Raven 36g, concave tile Wei 34g, Conyza canadensis (L.) Cronq. 18g, concha Anodonta seu Cristaria grass 27g, Herba Vernoniae Patulae 18g, Rhizoma Polygoni coriacei 20g, Folium Rubi 16g, Herba Thalictri Ichangensis 15g, Neoalsomitra integrifoliola (Cogn.) Hucth. 16g, Radix Sophorae Alopecuroidis 14g, spend bavin 14g in vain, Herba Camptosori Sibirici 17g, Herba conyzae blinii 7g, Herba Moslae Soochowensis 8g, comb leaf Artemisia 15g, Aranea grass 4g, Herba Swertiae Puniceae 8g medical material merges, it is the water of 10 times amount that first time adds with medical material weight ratio, decocting time 1h, it is the water of 8 times amount that second time adds with medical material weight ratio, decocting time 1h, filter, merge twice filtrate, filtrate reduced in volume becomes relative density 1.05 ~ 1.10 clear paste, adding ethanol makes determining alcohol reach 65%, cold preservation leaves standstill 24h, filter, filtrate becomes dried cream powder through drying under reduced pressure, sieve, for subsequent use,

By above-mentioned (1) in fine powder for subsequent use and (2) and (3) in dried cream powder for subsequent use, after mixing, obtaining final product, the active component of Chinese medicine composition of the present invention, with appropriate dextrin, sucrose, mixing, granulates, dry, makes granule.

The tablet preparation of embodiment 3 Chinese medicine composition of the present invention

(1), by Radix Atalantiae Buxifoliae 14g, paddy skin rattan 8g, the mixing of Fructus Seu Folium Kopsiae Officinalis 12g medical material, 50 DEG C of dry 3h, are ground into 100 order fine powders, for subsequent use;

(2) get Herba Cheilanthes chusane 27g, root of Pennisetum centrasiaticum Tzvel. 13g, Dou leaf banyan 6g is ground into coarse powder, adding 70% ethanol and infiltrate, is that 8 times amount 70% ethanol carry out percolation by medical material weight ratio, collect percolate, decompression recycling ethanol, after concentrated, drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;

(3) by Herba Adianti Flabellulati 36g, Ludwigia octovalvis (Jacq.) Raven 40g, concave tile Wei 30g, Conyza canadensis (L.) Cronq. 22g, concha Anodonta seu Cristaria grass 23g, Herba Vernoniae Patulae 22g, Rhizoma Polygoni coriacei 16g, Folium Rubi 20g, Herba Thalictri Ichangensis 11g, Neoalsomitra integrifoliola (Cogn.) Hucth. 20g, Radix Sophorae Alopecuroidis 18g, spend bavin 10g in vain, Herba Camptosori Sibirici 13g, Herba conyzae blinii 11g, Herba Moslae Soochowensis 12g, comb leaf Artemisia 11g, Aranea grass 8g, Herba Swertiae Puniceae 4g medical material merges, it is the water of 10 times amount that first time adds with medical material weight ratio, decocting time 1h, it is the water of 8 times amount that second time adds with medical material weight ratio, decocting time 1h, filter, merge twice filtrate, filtrate reduced in volume becomes relative density 1.05 ~ 1.10 clear paste, adding ethanol makes determining alcohol reach 65%, cold preservation leaves standstill 24h, filter, filtrate becomes dried cream powder through drying under reduced pressure, sieve, for subsequent use,

By above-mentioned (1) in fine powder for subsequent use and (2) and (3) in dried cream powder for subsequent use, after mixing, to obtain final product, the active component of Chinese medicine composition of the present invention, to mix with appropriate amount of starch, dextrin, to granulate, be pressed into tablet.

In order to verify the curative effect of final product composition having of the present invention further, the finished capsule product agent medicine of preparation in above-mentioned specific embodiment 1 has been carried out corresponding clinical trial by us, existing that report the test is as follows.

Chinese medicine composition of the present invention is to the clinical observation of chronic cholecystitis

1. physical data

Collect tested case 138 example of patient, be divided into 2 groups at random, wherein treatment group 73 example, age are 26 ~ 63 years old, the course of disease 8 months ~ 4 years; Matched group 65 example, the age is 28 ~ 60 years old; The course of disease 6 months ~ 3.5 years; All patients change no significant difference according to age, the course of disease, clinical symptoms and Abdominal B type ultrasonography, there is comparability.

2. diagnostic criteria

(1) tcm diagnosis standard

Primary symptom: 1. right flank pain, 2. bitter taste in the mouth and dry throat; Secondary disease: 1. pain draws the shoulder back of the body, 2. feel sick tending to vomit, 3. indigestion and loss of appetite abdominal distention, 4. anorexia is greasy, and ⑤Dan district is uncomfortable, 6. defecates not well or constipated, 7. yellowish or reddish urine, red tongue, yellow fur or yellow greasy, wiry and frequent pulse or stringy and rolling pulse.Above primary symptom is indispensable, and has secondary disease, tongue arteries and veins more than three persons, can diagnose.

(2) Western medicine diagnose standard

1. the right Upper abdominal pain of persistence or have discomfort or Ban You omoplate district pain, 2. nauseating, the indigestion symptom such as heating installation, acid regurgitation, abdominal distention and scorching hot is had, the postemphasis of feed greasy food, 3. the course of disease is long, more than 3 months, have the feature of recurrent exerbation, 4. can there be tenderness and percussion pain in gallbladder area, 5. the visible thickening of capsule wall of gallbladder of ultrasound diagnosis, crude, gallbladder reduce or enlargement, and gallbladder contraction function is bad.

(3) Excluded cases standard

1. the age is at under-18s or over-65s, gestation or women breast-feeding their children, allergic constitution or those who are allergic to this drug; 2. acute cholecystitis or cholangitis person is turned out to be on inspection; 3. cardiovascular, liver, kidney, pancreas and disease is merged, psychotic.

3. Therapeutic Method

Matched group: give DANSHU JIAONANG (Sibian Jishengtang Medicine Co., Ltd) oral medication, 3 tablets/time, 2 times/d, two groups was all 1 course for the treatment of with 1 month, took 2 courses for the treatment of continuously, and every 15 days records 1 change of illness state, terminates rear check B ultrasonic the course for the treatment of.Period in a medicine advises patient to avoid raw meat, the irritable food such as peppery, and diet is based on light easy to digest.

Treatment group: capsule prepared by the oral embodiment of the present invention 1,2 times/d, serve on 2 courses for the treatment of and evaluates its curative effect by 3 tablets/time.

4. efficacy assessment standard

Formulate with reference to " new Chinese medicine guideline of clinical investigations " (trying).Cure: clinical symptoms and sign all disappear, ultrasound diagnosis gallbladder is normal, follow up a case by regular visits to half a year ~ within 1 year, do not recur; Effective: clinical symptoms and sign obviously alleviate, ultrasound diagnosis gallbladder inflammation obviously alleviates; Effective: clinical symptoms and sign take a favorable turn, attack times reduces; Invalid: clinical symptoms and sign, ultrasound diagnosis is all without change.

5. therapeutic outcome

Table 1 liang group patient clinical comparitive study

Group	Case	Cure	Effective	Effectively	Invalid	Total effective rate
							Matched group	65	20	14	12	19	70.8％
Treatment group	73	36	17	18	2	97.3％

After the Drug therapy of 2 courses for the treatment of, Most patients clinical symptoms, sign substantially disappear or significantly alleviate, and diet recovers completely.From the experimental result of table 1, the total effective rate of traditional Chinese medicine composition for treating group of the present invention is 97.3%, and the patient's effective percentage taking matched group (DANSHU JIAONANG) is 70.8%.Result shows, the clinical efficacy for the treatment of group of the present invention is remarkable, and curative effect is obviously better than matched group (P < 0.05).

And in treatment clinical course, untoward reaction case does not occur for treatment group and matched group, this illustrates, Chinese medicine composition of the present invention is at treatment chronic cholecystitis determined curative effect, significantly, toxic and side effects is little, and clinic is applied.

6. model case

Case 1: Liu, man, 47 years old, chronic cholecystitis history was had a surplus for 3 years, and the good tobacco and wine of patient's element, preference for fat and sweet food, build is fat.Because of upper right abdomen paroxysmal distending pain, nausea and vomiting, is diagnosed as cholecystitis and cholelithiasis through B ultrasonic, alleviate after taking the treatment of antiinflammatory relieving spasm to stop pain sheet, but later whenever rich food dish then pain send out again, because patient is reluctant operative treatment, patient's upper right abdomen side of body flank pain during first visit, body weight is sleepy, gastral cavity abdomen feeling of fullness, indigestion and loss of appetite bitter taste, yellowish urine, constipation with dry stool, the micro-Huang of tongue fur and greasy, pulse condition stringy and rolling pulse, B ultrasonic shows that patient is cholecystitis, cholelithiasis, dialectically belongs to dampness-heat in the liver and gallbladder disease.Take the Chinese medicine capsules treatment of the invention process 1 group, after continuous 2 courses for the treatment of, all diseases disappear, and B ultrasonic check gallbladder is normal, and calculus disappears, and follows up a case by regular visits to half a year, has no recurrence.

Case 2: poplar, female, 33 years old, chronic cholecystitis history is had a surplus for 1 year, and feelings are smooth usually, easily angry angry, right Upper abdominal pain recurrent exerbation.Recently again show effect after feeling wronged and acting rashly with household, time medical, it is indefinite that upper right abdominal distention and pain is walked to alter, and pain connects side of body rib, and gastral cavity is vexed, belch is not smooth, poor appetite, thin fur, stringy pulse, health check-up upper right abdominal rib bow place tenderness.Rough through ultrasound diagnosis prompting thickening of capsule wall of gallbladder, volume slightly increases, and clinical diagnosis is chronic cholecystitis.Chinese medical discrimination belongs to liver qi stagnation type.Take the Chinese medicine capsules treatment of the invention process 1 group, and advise regulating spirit and emotion by oneself, avoid suffering from cold, pungent irritable food such as grade of avoiding cold and uncooked food.After taking 2 courses for the treatment of continuously, clinical symptoms, sign is recovered completely, check B ultrasonic prompting: gallbladder volume is normal, and gallbladder wall is smooth.Follow up a case by regular visits to after treatment and do not fall ill again for 1 year.

Case 3: Zhao, man, 56 years old, chronic cholecystitis history was had a surplus for 2 years, usually the product of the pungent greasy savoury of eating.Over this month nearly, patient's upper right abdomen side of body flank pain recurrent exerbation, take a turn for the better after western medical treatment, spend six months, patient disease recurs, therefore changes throwing Chinese traditional treatment.Time medical, upper right distention and fullness in the abdomen pain, tenderness, pain is often radiated to right shoulder back, and has burning sensation, food poor appetite, and companion feels sick, xerostomia is bitter, constipation, red tongue yellow and greasy fur, wiry and frequent pulse.Upper right abdominal pressure pain obviously, is pointed out through ultrasound diagnosis: gallbladder volume increases, and gallbladder wall is coarse, and clinical diagnosis is chronic cholecystitis.Chinese medical discrimination belongs to liver gallbladder damp-heat type, take the Chinese medicine capsules treatment of the invention process 1 group, and advise and take light product, avoid pungent greasy thing, after 2 courses for the treatment of of taking medicine continuously, clinical symptoms, through check B ultrasonic, basic disappearance, shows that gallbladder volume form is normal, gallbladder wall from coarse become smooth, follow up a case by regular visits to 1 year after treatment, do not fall ill again.

Claims (5)

1. treat the Chinese medicine composition of chronic cholecystitis for one kind, it is characterized in that, it is made up of the crude drug of following weight portion: Herba Adianti Flabellulati 36 ~ 40 parts, Ludwigia octovalvis (Jacq.) Raven 36 ~ 40 parts, concave tile Wei 30 ~ 34 parts, Conyza canadensis (L.) Cronq. 18 ~ 22 parts, Herba Cheilanthes chusane 23 ~ 27 parts, concha Anodonta seu Cristaria grass 23 ~ 27 parts, Herba Vernoniae Patulae 18 ~ 22 parts, Rhizoma Polygoni coriacei 16 ~ 20 parts, Folium Rubi 16 ~ 20 parts, Herba Thalictri Ichangensis 11 ~ 15 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 16 ~ 20 parts, Radix Sophorae Alopecuroidis 14 ~ 18 parts, Radix Atalantiae Buxifoliae 10 ~ 14 parts, spend bavin 10 ~ 14 parts in vain, Herba Camptosori Sibirici 13 ~ 17 parts, root of Pennisetum centrasiaticum Tzvel. 13 ~ 17 parts, Herba conyzae blinii 7 ~ 11 parts, 8 ~ 12 parts, paddy skin rattan, Herba Moslae Soochowensis 8 ~ 12 parts, Fructus Seu Folium Kopsiae Officinalis 12 ~ 16 parts, comb leaf Artemisia 11 ~ 15 parts, Dou leaf banyan 6 ~ 10 parts, Aranea grass 4 ~ 8 parts, 4 ~ 8 parts, Herba Swertiae Puniceae.

2. the Chinese medicine composition for the treatment of chronic cholecystitis as claimed in claim 1, it is characterized in that, it is made up of the crude drug of following weight portion: Herba Adianti Flabellulati 38 parts, Ludwigia octovalvis (Jacq.) Raven 38 parts, concave tile Wei 32 parts, Conyza canadensis (L.) Cronq. 20 parts, Herba Cheilanthes chusane 25 parts, concha Anodonta seu Cristaria grass 25 parts, Herba Vernoniae Patulae 20 parts, Rhizoma Polygoni coriacei 18 parts, Folium Rubi 18 parts, Herba Thalictri Ichangensis 13 parts, Neoalsomitra integrifoliola (Cogn.) Hucth. 18 parts, Radix Sophorae Alopecuroidis 16 parts, Radix Atalantiae Buxifoliae 12 parts, spend bavin 12 parts in vain, Herba Camptosori Sibirici 15 parts, root of Pennisetum centrasiaticum Tzvel. 15 parts, Herba conyzae blinii 9 parts, 10 parts, paddy skin rattan, Herba Moslae Soochowensis 10 parts, Fructus Seu Folium Kopsiae Officinalis 14 parts, comb leaf Artemisia 13 parts, Dou leaf banyan 8 parts, Aranea grass 6 parts, 6 parts, Herba Swertiae Puniceae.

3. a preparation method for the Chinese medicine composition for the treatment of chronic cholecystitis as claimed in claim 1 or 2, it is characterized in that, it is made up of following step:

(1), by Radix Atalantiae Buxifoliae, paddy skin rattan, the mixing of Fructus Seu Folium Kopsiae Officinalis medical material, 50 DEG C of dry 3h, are ground into 100 order fine powders, for subsequent use;

(2) get Herba Cheilanthes chusane, root of Pennisetum centrasiaticum Tzvel., Dou leaf banyan be ground into coarse powder, infiltrate with 70% ethanol, adding medical material weight ratio is that 8 times amount 70% ethanol carry out percolation, collects percolate, decompression recycling ethanol, and after concentrated, drying, and be ground into dried cream powder, sieve, medicinal residues are for subsequent use;

(3) by Herba Adianti Flabellulati, Ludwigia octovalvis (Jacq.) Raven, concave tile Wei, Conyza canadensis (L.) Cronq., concha Anodonta seu Cristaria grass, Herba Vernoniae Patulae, Rhizoma Polygoni coriacei, Folium Rubi, Herba Thalictri Ichangensis, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Sophorae Alopecuroidis, spend bavin in vain, Herba Camptosori Sibirici, Herba conyzae blinii, Herba Moslae Soochowensis, comb leaf Artemisia, Aranea grass, Herba Swertiae Puniceae medical material merges, it is the water of 10 times amount that first time adds with medical material weight ratio, decocting time 1h, it is the water of 8 times amount that second time adds with medical material weight ratio, decocting time 1h, filter, merge twice filtrate, filtrate reduced in volume becomes relative density 1.05 ~ 1.10 clear paste, adding ethanol makes determining alcohol reach 65%, cold preservation leaves standstill 24h, filter, filtrate becomes dried cream powder through drying under reduced pressure, sieve, for subsequent use,

By above-mentioned (1) in fine powder for subsequent use and (2) and (3) in dried cream powder for subsequent use, after mixing, to obtain final product, the active component of Chinese medicine composition of the present invention.

4. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that this Chinese medicine composition is granule, tablet or hard capsule.

5. the application of Chinese medicine composition as claimed in claim 1 or 2 in preparation treatment chronic cholecystitis medicine.