CN104815319A - 治疗慢性心力衰竭的方法 - Google Patents
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- CN104815319A CN104815319A CN201510202983.1A CN201510202983A CN104815319A CN 104815319 A CN104815319 A CN 104815319A CN 201510202983 A CN201510202983 A CN 201510202983A CN 104815319 A CN104815319 A CN 104815319A
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
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- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
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| US20124008P | 2008-12-08 | 2008-12-08 | |
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| CA2724540C (en) | 2008-05-16 | 2014-07-08 | Corthera, Inc. | Treating dyspnea associated with acute heart failure with relaxin |
| BR112012022654A2 (pt) | 2010-03-10 | 2016-11-01 | Univ Florida | modulação de aquaporinas com relaxina |
| US20130336979A1 (en) * | 2010-12-01 | 2013-12-19 | Fatima Smih | Diagnostic and treatment of chronic heart failure |
| MX2014000316A (es) * | 2011-07-08 | 2014-02-19 | Bayer Ip Gmbh | Proteinas de fusion liberadoras de relaxina y usos de las mismas. |
| AU2012291972B2 (en) * | 2011-08-04 | 2017-03-09 | Pharis Biotec Gmbh | Process for preparing human relaxin-2 |
| WO2013033324A2 (en) | 2011-08-31 | 2013-03-07 | University Of Florida Research Foundation, Inc. | Materials and methods for modulating activity of bone marrow derived cells |
| US20140364334A1 (en) * | 2011-12-21 | 2014-12-11 | Nuclea Biotechnologies, Inc. | Congestive heart failure biomarkers |
| EP2814513B1 (en) | 2012-02-14 | 2017-12-20 | The Regents of The University of California | Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions |
| WO2014115033A2 (en) * | 2013-01-25 | 2014-07-31 | Cardiorentis Ltd. | Methods of treating cardiovascular indications |
| HK1211594A1 (en) * | 2013-11-07 | 2016-05-27 | 上海恒瑞医药有限公司 | Human relaxin analogue, pharmaceutical composition of same, and pharmaceutical application of same |
| US10500227B2 (en) * | 2014-12-03 | 2019-12-10 | University Of Cincinnati | Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease |
| DK3387019T3 (da) | 2015-12-09 | 2022-01-10 | Scripps Research Inst | Relaxin-immunoglobulinfusionsproteiner og anvendelsesfremgangsmåder |
| MX2019008449A (es) | 2017-02-08 | 2019-09-09 | Bristol Myers Squibb Co | Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos. |
| CN107335051A (zh) * | 2017-08-18 | 2017-11-10 | 温州医科大学附属第医院 | 一种保护慢性心衰肾功能的药物组合物 |
| US20220008508A1 (en) * | 2018-11-20 | 2022-01-13 | Universität Heidelberg | Relaxin receptor 1 for use in treatment and prevention of heart failure |
| US12226455B2 (en) | 2019-11-16 | 2025-02-18 | Relaxera Pharmazeutische Gmbh & Co. Kg | Medical composition for treating cardiac wasting and cachexia |
| EP4192580A4 (en) * | 2020-08-05 | 2025-06-18 | AskBio Inc. | Methods for treating heart disease and congestive heart failure and administration of AAV vectors |
| RU2748529C1 (ru) * | 2020-09-01 | 2021-05-26 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр кардиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ кардиологии" Минздрава России) | Способ определения этиологии хронической сердечной недостаточности |
| IL321288A (en) * | 2022-12-09 | 2025-08-01 | Astrazeneca Ab | Dosing regimens using fusions of relaxin heterodimers |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| WO2002040500A2 (en) * | 2000-11-16 | 2002-05-23 | Immundiagnostik Ag | Method of prognosis and diagnosis of congestive heart failure |
| US20080077025A1 (en) * | 2005-07-11 | 2008-03-27 | Leticia Delgado-Herrera | Methods for determining how to treat congestive heart failure |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5023321A (en) | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| CA2165781C (en) | 1993-06-21 | 2007-02-13 | Tim Breece | Process for producing relaxin |
| US5811395A (en) | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| RU2213559C2 (ru) * | 2000-01-26 | 2003-10-10 | Тюменская государственная медицинская академия | Способ лечения больных хронической сердечной недостаточностью на фоне ишемической болезни сердца |
| US20050113286A1 (en) * | 2002-03-18 | 2005-05-26 | Schreiner George F. | Methods for treating congestive heart failure |
| EP1729817B1 (en) * | 2004-03-30 | 2014-03-05 | Industry-Academic Cooperation Foundation | Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin |
| WO2009007848A2 (en) | 2007-07-12 | 2009-01-15 | Compugen Ltd. | Bioactive peptides and method of using same |
| CA2724540C (en) * | 2008-05-16 | 2014-07-08 | Corthera, Inc. | Treating dyspnea associated with acute heart failure with relaxin |
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2009
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- 2009-05-15 EP EP09747738A patent/EP2288366A4/en not_active Ceased
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| WO2002040500A2 (en) * | 2000-11-16 | 2002-05-23 | Immundiagnostik Ag | Method of prognosis and diagnosis of congestive heart failure |
| US20080077025A1 (en) * | 2005-07-11 | 2008-03-27 | Leticia Delgado-Herrera | Methods for determining how to treat congestive heart failure |
Non-Patent Citations (2)
| Title |
|---|
| O. DAVID SHERWOOD: "Relaxin’s Physiological Roles and Other Diverse Actions", 《ENDOCRINE REVIEWS》 * |
| T.DSCHIETZIG等: "A pilot safety and dose-finding trial of intravenous recombinant human relaxin (rhRlx) in compensated congestive heart failure", 《EUROPEAN JOURNAL OF HEART FAILURE SUPPLEMENTS》 * |
Also Published As
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| US20160287672A1 (en) | 2016-10-06 |
| BRPI0912559A2 (pt) | 2015-10-13 |
| MX336145B (es) | 2016-01-08 |
| EP2288366A2 (en) | 2011-03-02 |
| RU2512933C2 (ru) | 2014-04-10 |
| JP2011520917A (ja) | 2011-07-21 |
| EP2288366A4 (en) | 2012-05-02 |
| US20140005112A1 (en) | 2014-01-02 |
| AU2009246112A1 (en) | 2009-11-19 |
| EP3150219A1 (en) | 2017-04-05 |
| CN102026649A (zh) | 2011-04-20 |
| RU2010151470A (ru) | 2012-06-27 |
| CA2724535A1 (en) | 2009-11-19 |
| JP2017061453A (ja) | 2017-03-30 |
| US20110144019A1 (en) | 2011-06-16 |
| MX2010012502A (es) | 2011-04-11 |
| JP2014237648A (ja) | 2014-12-18 |
| AU2009246112B2 (en) | 2013-05-02 |
| WO2009140657A2 (en) | 2009-11-19 |
| WO2009140657A3 (en) | 2010-01-07 |
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