CN104800721A - Medicine composition for treating radiation proctitis after radiation therapy for treating cervical cancer - Google Patents
Medicine composition for treating radiation proctitis after radiation therapy for treating cervical cancer Download PDFInfo
- Publication number
- CN104800721A CN104800721A CN201510175736.7A CN201510175736A CN104800721A CN 104800721 A CN104800721 A CN 104800721A CN 201510175736 A CN201510175736 A CN 201510175736A CN 104800721 A CN104800721 A CN 104800721A
- Authority
- CN
- China
- Prior art keywords
- parts
- cervical cancer
- treating
- radiation
- irradiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses medicine composition for treating radiation proctitis after radiation therapy for treating cervical cancer. The liquid medicine is prepared from raw traditional Chinese medicine materials in parts by weight as follows: 7-15 parts of roots of fructus schisandrae sphenantherae, 11-20 parts of silene adenantha Franch., 10-25 parts of flos sophorae, 6-10 parts of galanga galangal seeds, 22-40 parts of chestnut pericarp, 6-10 parts of fineleaf schizonepeta herb, 9-20 parts of humifuse euphorbia herb, 6-20 parts of Chinese honeylocust spine and 11-20 parts of poederia scandens. The medicine composition for treating chronic radiation proctitis through enema has a definite curative effect and is safe and reliable.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to the pharmaceutical composition of radiation rectitis after a kind of enema treatment irradiation for cervical cancer.
Background technology
Cervical cancer is modal tumor of pelvic cavity, occupy gynecologic malignant tumor first place, and radiotherapy is the primary treatments of cervical cancer in China always.Chronic radioactive proctitis is a kind of common complication occurred after irradiation for cervical cancer, delayed by acute radioactive rectitis or cause interstitial fibrosis after direct irradiation half a year, artery occlusive intimitis and cause rectum chronic inflammatory disease, bowel narrow, ulcer and fistulization caused by local organization ischemia, the serious radiation injury of permanent protracted course of disease can be caused, it brings very large misery to patient, has a strong impact on the life quality of patient.
At present, there is no standard treatments both at home and abroad, whole body therapeutic is treated based on infection, hemostasis, reinforcement nutrition etc., topical therapeutic is mainly with compound recipe procaine enema (procaine+gentamycin+steroid hormone) coloclysis, there is certain curative effect, but studies have found that, the enema that life-time service contains steroid hormone can cause Fu Niye gangrene, and can make exacerbation of symptoms of having blood in stool.Therefore, find safer effective Therapeutic Method and seem particularly important.
Summary of the invention
In view of the deficiencies in the prior art, the object of the present invention is to provide pharmaceutical composition and the application thereof of radiation rectitis after a kind of enema treatment irradiation for cervical cancer.
The object of the present invention is achieved like this:
A kind of pharmaceutical composition for the treatment of radiation rectitis after irradiation for cervical cancer, be prepared from by traditional Chinese medicinal material raw materials, by weight, described traditional Chinese medicinal material raw materials comprises: RADIX KADSURAE LONGIPEDUN LATAE 7-15 part, HEIQIANNIU 11-20 part, Flos Sophorae 10-25 part, Fructus Galangae 6-10 part, epicarpium Castaneae 22-40 part, Herba Schizonepetae 6-10 part, Herba Euphorbiae Humifusae 9-20 part, Spina Gleditsiae 6-10 part, fevervine 11-20 part.
Preferably, the pharmaceutical composition of radiation rectitis after treatment irradiation for cervical cancer described above, by weight, described traditional Chinese medicinal material raw materials is made up of RADIX KADSURAE LONGIPEDUN LATAE 9-12 part, HEIQIANNIU 14-16 part, Flos Sophorae 15-21 part, Fructus Galangae 7-9 part, epicarpium Castaneae 28-32 part, Herba Schizonepetae 7-9 part, Herba Euphorbiae Humifusae 13-15 part, Spina Gleditsiae 7-9 part and fevervine 14-16 part.
In a most preferred embodiment of the present invention, the pharmaceutical composition of radiation rectitis after treatment irradiation for cervical cancer described above, by weight, described traditional Chinese medicinal material raw materials is made up of RADIX KADSURAE LONGIPEDUN LATAE 10 parts, HEIQIANNIU 15 parts, 18 parts, Flos Sophorae, Fructus Galangae 8 parts, epicarpium Castaneae 30 parts, Herba Schizonepetae 8 parts, Herba Euphorbiae Humifusae 14 parts, Spina Gleditsiae 8 parts and fevervine 15 parts.
The preparation method of the coloclysis medicinal liquid that the present invention relates to comprises the steps: to get RADIX KADSURAE LONGIPEDUN LATAE 7-15 part, HEIQIANNIU 11-20 part, Flos Sophorae 10-25 part, Fructus Galangae 6-10 part, epicarpium Castaneae 22-40 part, Herba Schizonepetae 6-10 part, Herba Euphorbiae Humifusae 9-20 part, Spina Gleditsiae 6-10 part and fevervine 11-20 part, merge, be ground into granule, again above-mentioned graininess medical material is added water and cover powder, soak 0.5-1.5h, decoct with water 1-4 time, decocting liquid four layers of gauze are filtered, heating is concentrated into the medicinal liquid that crude drug content is 0.3-1.0g/ml, add appropriate antiseptic, obtain coloclysis medicinal liquid.
It should be noted that, the traditional Chinese medicinal material raw materials that pharmaceutical composition of the present invention adopts has following source: RADIX KADSURAE LONGIPEDUN LATAE selects the dry root of Magnoliacea plant schisandra chinensis Schisandra sphenanthera Rehd.et Wils..HEIQIANNIU selects the dry root of pinkwort gland flower Herba Melandrii Aprici Silene adenantha Franch..Flos Sophorae selects the dry flower and alabastrum of leguminous plant Chinese scholartree Sophora japonica L..Fructus Galangae selects the dry mature fruit of zingiberaceous plant Rhizoma Alpiniae Galangae Alpiniagalanga Willd..Epicarpium Castaneae selects the dry outer peel of Fagaceae Semen Castaneae Castanea mollissima Bl..Herba Schizonepetae selects the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Herba Euphorbiae Humifusae selects the dry herb of euphorbia plant Radix seu Caulis Parthenocissi tricuspidatae Euphorbia humifusa Willd..Spina Gleditsiae selects the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Fevervine selects the dry root of Rubiaceae Paederia plant fevervine Paederia scandens (Lour.) Merr..
The present invention is by chronic radioactive proctitis after herbal drug enema in treatment irradiation for cervical cancer, and compare with employing compound recipe procaine enema enema treatment, show two groups of treatments all effective, but test group at total effective rate, improve in symptom overall score and be obviously better than matched group.Also there is not adverse events in test group, illustrates that pharmaceutical composition of the present invention is through enema treatment chronic radioactive proctitis determined curative effect, and safe and reliable.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Take RADIX KADSURAE LONGIPEDUN LATAE 1.0kg, HEIQIANNIU 1.5kg, Flos Sophorae 1.8kg, Fructus Galangae 0.8kg, epicarpium Castaneae 3.0kg, Herba Schizonepetae 0.8kg, Herba Euphorbiae Humifusae 1.4kg, Spina Gleditsiae 0.8kg and fevervine 1.5kg, merge, be ground into granule, again above-mentioned graininess medical material is added water and cover powder 2cm, soak 1h, decoct with water 2 times, add up the water of medical material 15 times amount for the first time, decoct 3h, get decocting liquid, filter, second time adds up the water of medical material 12 times amount, decoct 2h, get twice decocting liquid to merge, 4 layers of gauze filter, heating is concentrated into the medicinal liquid that crude drug content is 0.5g/ml, add 0.05% antiseptic, obtain coloclysis medicinal liquid.
Embodiment 2 liquid medicine enema is to the effectiveness study of chronic radioactive proctitis patient after irradiation for cervical cancer
Cervical cancer chronic radioactive proctitis inpatient 42 example, the mean age (53.1 ± 9.4) year, from radiotherapy to occurring chronic radioactive proctitis (8.9 ± 1.4) moon average time; Symptom overall score (5.90 ± 1.26) point; Wherein 29 examples are accidental has blood in stool, mucosa edema, and defecation is irregular, loose stool or constipation; 10 examples are commonly had blood in stool, and mucosa is plump, proctostenosis, difficult defecation, and still available drugs is alleviated, 3 routine whole bloods just, ulcer or fistulization, proctostenosis, defecation exceptional hardship, even blocks.Simple randomization digits table all patients is adopted to be divided into test group and each 21 examples of matched group.The equal not statistically significants of difference such as two groups of ages, chronic radioactive proctitis time of origin, chronic radioactive proctitis state of an illness, have comparability.
The enema that test group adopts the embodiment of the present invention 1 to prepare is about 200mL and is placed in enema bag, and 2 retention enemas every day, each 15 minutes 2 weeks was 1 course for the treatment of.The compound recipe procaine enema that matched group adopts " Occupational sanitary standard " to recommend, concrete formula: 0.25% procaine 200m l+ gentamycin 80,000 units+prednisone 10m,g+1 ‰ epinephrine 2ml; 2 retention enemas every day, each 15 minutes 2 weeks was 1 course for the treatment of.Test group and matched group respectively observed for 1 course for the treatment of.
Curative effect determinate standard is formulated about the curative effect determinate standard of " new Chinese medicine treats the guideline of clinical investigations of having loose bowels " with reference to " new Chinese medicine guideline of clinical investigations ".(1) fully recover: transference cure or substantially disappear, symptom overall score reduces >=95%.(2) effective: symptom is obviously improved, 70%≤symptom overall score reduces < 95%.(3) effective: symptom takes a turn for the better to some extent, 30%≤symptom overall score reduces < 70%.(4) invalid: symptom is not improved, even increase the weight of, symptom overall score reduces < 30%.The rear overall score of overall score-treatment before the slip=[﹙ that marks treats) the front overall score of/treatment] × 100%.Total effective rate=[﹙ recovery from illness number of cases+effective number of cases+effectively number of cases)/total the number of cases of this group] × 100%.
" common sympton scalar quantization table of having loose bowels " that symptom score canonical reference " new Chinese medicine guideline of clinical investigations " designs about " new Chinese medicine treats the guideline of clinical investigations of having loose bowels " is formulated.Symptom overall score=stool and frequency are scored+have blood in stool score+difficult defecation degree score.
Stool and frequency: stool is shaped substantially, defecation every day less than 3 times meters 0 point; Stool can not be shaped, and every day counts 1 point 3 ~ 4 times; Loose stool, every day counts 2 points 5 ~ 10 times; Stool is as water sample, and every day more than 10 times counts 3 points.
Have blood in stool: without having blood in stool meter 0 point; To have blood in stool once in a while meter 1 point; Often to have blood in stool meter 2 points; Whole blood just counts 3 points.
Difficult defecation degree: without difficult defecation meter 0 point; Defecation is slightly difficult, and each defecation time is less than 30 minutes and counts 1 point; Difficult defecation, each defecation time counted 2 points between 30 minutes ~ 1 hour; Defecation exceptional hardship, each defecation time is greater than 1 hour and counts 3 points.
General curative effect comparative result is see table 1.Result shows, and test group total effective rate 95.2%, is better than matched group (76.23%).In addition, after treating 1 course for the treatment of, the symptom general comment of matched group is divided into (2.87 ± 1.05) point, and the symptom general comment of test group is divided into (0.94 ± 0.33) point, has significant difference (P < 0.01) compared with matched group.
A table 1 liang group general curative effect compares
Claims (5)
1. treat the pharmaceutical composition of radiation rectitis after irradiation for cervical cancer for one kind, it is characterized in that: this pharmaceutical composition is prepared from by traditional Chinese medicinal material raw materials, by weight, described traditional Chinese medicinal material raw materials comprises: RADIX KADSURAE LONGIPEDUN LATAE 7-15 part, HEIQIANNIU 11-20 part, Flos Sophorae 10-25 part, Fructus Galangae 6-10 part, epicarpium Castaneae 22-40 part, Herba Schizonepetae 6-10 part, Herba Euphorbiae Humifusae 9-20 part, Spina Gleditsiae 6-10 part, fevervine 11-20 part.
2. treat the pharmaceutical composition of radiation rectitis after irradiation for cervical cancer according to claim 1, it is characterized in that: by weight, described traditional Chinese medicinal material raw materials is made up of RADIX KADSURAE LONGIPEDUN LATAE 9-12 part, HEIQIANNIU 14-16 part, Flos Sophorae 15-21 part, Fructus Galangae 7-9 part, epicarpium Castaneae 28-32 part, Herba Schizonepetae 7-9 part, Herba Euphorbiae Humifusae 13-15 part, Spina Gleditsiae 7-9 part and fevervine 14-16 part.
3. treat the pharmaceutical composition of radiation rectitis after irradiation for cervical cancer according to claim 1, it is characterized in that: by weight, described traditional Chinese medicinal material raw materials is made up of RADIX KADSURAE LONGIPEDUN LATAE 10 parts, HEIQIANNIU 15 parts, 18 parts, Flos Sophorae, Fructus Galangae 8 parts, epicarpium Castaneae 30 parts, Herba Schizonepetae 8 parts, Herba Euphorbiae Humifusae 14 parts, Spina Gleditsiae 8 parts and fevervine 15 parts.
4. the application in the external used medicine of claim 1 or the medicinal raw material compositions described in 2 or 3 chronic radioactive proctitis after preparation treatment irradiation for cervical cancer.
5. application according to claim 4, is characterized in that, described external used medicine is enema.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510175736.7A CN104800721B (en) | 2015-04-14 | 2015-04-14 | A kind of pharmaceutical composition for treating factitial proctitis after irradiation for cervical cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510175736.7A CN104800721B (en) | 2015-04-14 | 2015-04-14 | A kind of pharmaceutical composition for treating factitial proctitis after irradiation for cervical cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104800721A true CN104800721A (en) | 2015-07-29 |
| CN104800721B CN104800721B (en) | 2018-06-19 |
Family
ID=53686200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510175736.7A Expired - Fee Related CN104800721B (en) | 2015-04-14 | 2015-04-14 | A kind of pharmaceutical composition for treating factitial proctitis after irradiation for cervical cancer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104800721B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127317A (en) * | 2013-01-17 | 2013-06-05 | 田洪蕾 | Enema for treating radiation proctitis |
| CN103211883A (en) * | 2013-04-15 | 2013-07-24 | 李涌 | Chinese medicinal enema for treating cervical cancer chronic radiation proctitis |
-
2015
- 2015-04-14 CN CN201510175736.7A patent/CN104800721B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127317A (en) * | 2013-01-17 | 2013-06-05 | 田洪蕾 | Enema for treating radiation proctitis |
| CN103211883A (en) * | 2013-04-15 | 2013-07-24 | 李涌 | Chinese medicinal enema for treating cervical cancer chronic radiation proctitis |
Non-Patent Citations (1)
| Title |
|---|
| 郭峰 等: "中医治疗放射性肠炎48例临床观察", 《甘肃医药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104800721B (en) | 2018-06-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103768398A (en) | Traditional Chinese medicine composition for treating advanced lung tumors | |
| CN103893738B (en) | A kind of suppression tumor growth Chinese medicine composition and preparation method thereof | |
| CN105617151A (en) | Powder boiling type traditional Chinese medicine antibacterial and anti-inflammatory agent, preparation method and applications thereof | |
| CN104958448A (en) | Medicine for treating puerperal infection | |
| CN103157014B (en) | Miao medicine for treating tumors | |
| CN105213974A (en) | One treats lymphadenomatous Chinese medicine composition and application thereof | |
| CN101085088A (en) | Traditional Chinese medicine formula for treating prostatic hyperplasia | |
| CN104800721A (en) | Medicine composition for treating radiation proctitis after radiation therapy for treating cervical cancer | |
| CN104623381A (en) | Traditional-Chinese-medicine composition for treating skin disease caused by blood heat and liver depression | |
| CN104800288A (en) | Traditional Chinese medicine for treating acute viral pharyngitis | |
| CN103520475B (en) | A kind of pharmaceutical composition being used for the treatment of skin pruritus | |
| CN103007202A (en) | Traditional Chinese medicine composition for treating pancreatic cancer | |
| CN105012789A (en) | Composition for treating cervical cancer and preparation method thereof | |
| CN105012888A (en) | Composition for treating carcinoma of uterine cervix and preparing method | |
| CN105288158A (en) | Traditional Chinese medicine for treatment of cold-dampness type chronic rhinitis | |
| CN105412392A (en) | Traditional Chinese medicinal composition for treating hemorrhoids and preparation method of traditional Chinese medicinal composition | |
| CN104940635A (en) | Scald and burn traditional Chinese medicine compound for external use | |
| CN105456499A (en) | Traditional Chinese medicine preparation for treating constipation and preparation method | |
| CN105412766A (en) | Pharmaceutical composition for treating chronic diarrhea | |
| CN104306491B (en) | Chinese medicine composition and the method for making for the treatment of aphthae | |
| CN114306461A (en) | Traditional Chinese medicine preparation for treating haemorrhoids and preparation method | |
| CN114949136A (en) | Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method and application thereof | |
| CN102389538A (en) | Traditional Chinese medicine capsule preparation for treating nasopharyngitis | |
| CN102327523A (en) | Traditional Chinese medicine for treating impetigo herpetiformis | |
| CN108553525A (en) | A kind of Chinese traditional compound medicine and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Song Xiufeng Inventor after: Zhuang Xunhui Inventor after: Li Weikai Inventor before: Song Xiufeng Inventor before: Liu Guangzhen Inventor before: Chen Jingjing Inventor before: Hua Hui Inventor before: Wang Guohua |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180517 Address after: 266000 217 Liaoyang West Road, Shibei District, Qingdao, Shandong Applicant after: QINGDAO WOMEN AND CHILDREN'S HOSPITAL Address before: No. 16, Jiangsu Road, Southern District, Shandong, Qingdao, Shandong Applicant before: Affiliated Hospital of University Of Qingdao |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180619 Termination date: 20190414 |