CN104800417A - Application of traditional Chinese medicine composition for preparing medicine for increasing erythrocyte - Google Patents
Application of traditional Chinese medicine composition for preparing medicine for increasing erythrocyte Download PDFInfo
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- CN104800417A CN104800417A CN201510216069.2A CN201510216069A CN104800417A CN 104800417 A CN104800417 A CN 104800417A CN 201510216069 A CN201510216069 A CN 201510216069A CN 104800417 A CN104800417 A CN 104800417A
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Abstract
The invention relates to new use of a chemical compound traditional Chinese medicine composition in the field of preparing medicines. The traditional Chinese medicine composition is prepared from 18 parts of radix pueraiae, 20 parts of salixmicrostachya, 15 parts of beautyberry leaves, 12 parts of common origanum herb, and 20 parts of justicia, can increase the erythrocyte, and has remarkable progress.
Description
Technical field
The present invention relates to the novelty teabag of Chinese medicine composition, particularly relate to the application of Chinese medicine composition in preparation rising erythrocyte medicine.
Background technology
Erythrocyte is on the low side is the clinical manifestation of having suffered from iron Deficiency Anemia.Iron deficiency anemia refers to and refers to that the demand and supply of body to ferrum is unbalance, and when causing the content of the most erythrocytic quantity of storage iron loss and hemoglobin in body to reduce to a certain degree, then Erythrocyte Iron lacks thus the anemia caused.Iron deficiency anemia is modal anemia.At the cradle that growth promoter is the most vigorous, if the ferrum stored in body be exhausted and in diet the content of ferrum inadequate, to the incomplete absorption replenishment of blood content of ferrum and erythrocytic increase, can anemia be there is in digestive tract.
Summary of the invention
A kind of Chinese medicine composition has been the object of the present invention is to provide to raise the application in erythrocyte medicine in preparation.
Chinese medicine composition raises the application in erythrocyte medicine in preparation, and described Chinese medicine composition is prepared by the raw material of following parts by weight: Ge Xian 18 parts, horse Radix Salicis Babylonicae 20 parts, Folium Callicarpae Formosanae 15 parts, Herba Origani 12 parts, Herba Rostellulariae 20 parts.
The preparation method of described Chinese medicine composition is: get above-mentioned Chinese medicine, decocts with water 2 times, and amount of water is 10 times amount of medical material weight for the first time, decocts 2 hours, second time amount of water is 8 times amount of medical material weight, decocts 1 hour, collecting decoction, concentrated, dry, pulverize to obtain traditional Chinese medicine particle.
In the preparation method of described Chinese medicine composition, concentrated condition is: when being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C, relative density is 1.30.Spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.
Ge Xian is the frond of nostocaceae plant Nostoc.Relieve inflammation or internal heat, improving eyesight, defying age, the therapeutic efficiency such as infection.
Horse Radix Salicis Babylonicae is root and the fibrous root of Salicaceous Plants crow willow.Heat clearing away, pathogenic fire purging, pleasant.Control acute toothache, acute lumbar muscle sprain.
Folium Callicarpae Formosanae is the leaf of Verbenaceae Folium Callicarpae Macrophyllae Callicarpamacrophyllavahl.Astringing to arrest bleeding, heat-clearing and toxic substances removing.
Herba Origani is Labiatae Elsholtzia species Herba Origani Elsholtzia ciliata (Thunb.) Hyland. [E.patrini (Lepech.) Garcke], with all herbal medicine.Summer, autumn tap when heading is bloomed, and remove impurity and dry or using fresh herb.Diaphoresis, expelling summer-heat, diuresis.Summer catches a cold, fever without perspiration, heatstroke, and acute gastroenteritis is uncomfortable in chest, halitosis, dysuria.
Herba Rostellulariae (Classification system: Rostellularia procumbens (L.) Nees) annual draft of crawling, leaf is to life; Avette, oblong or wide lanceolar, spike top is raw or axil is raw, corolla pale red or band aubergine, and filigree base portion and attachment region surrounding have fine hair, style is thread, stigma head, capsule is linear, the short point of tip, base portion is ashamed narrow, all in flattening shape, light brown, upper surface has white pubescence.Seed oval and micro-flat, pitchy, it is protruding that surface has netted stricture of vagina.8 ~ November of florescence.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, preventing the attack (or recurrence) of malaria.For cold, fever, malaria, laryngopharynx swelling and pain, infantile malnutrition, dysentery, enteritis, oedema due to nephritis, urinary system infection, chyluria; External is controlled carbuncle furuncle and is swollen, traumatic injury.
The purposes of the Chinese medicine composition that the present invention relates in preparation treatment erythrocyte low medicine thing belongs to first public, because Chinese medicine ingredients is complicated, and it is unexpectedly strong for the low inhibit activities of erythrocyte, there is not the possibility being provided any enlightenment by other Chinese medicines, possess outstanding substantive distinguishing features, for the control that erythrocyte is low, obviously there is significant progress simultaneously.
Detailed description of the invention
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Embodiment 1: get Ge Xian 18g, horse Radix Salicis Babylonicae 20g, Folium Callicarpae Formosanae 15g, Herba Origani 12g, Herba Rostellulariae 20g, decoct with water 2 times, first time, amount of water was 10 times amount of medical material weight, and decoct 2 hours, second time amount of water is 8 times amount of medical material weight, decoct 1 hour, collecting decoction, concentrated, dry, pulverize to obtain traditional Chinese medicine particle, concentrated condition is: when being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C, relative density is 1.30.Spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.
Embodiment 2:
One, Chinese medicine composition is to the therapeutical effect of post hemorrhagic mice
1, test drug: prepare test drug according to the method for above-described embodiment 1.
2, method: affect ICR mice 40, ♀ ♂ half and half to post hemorrhagic mice, is divided into 4 groups (n=10).Except normal saline group, other group every mice, from orbital vein blood-letting 0.5ml, is got blood survey again and all respectively organizes index after 24h, then continuous gastric infusion 1 week, after last administration 1h, gets the full whole bliid platelet analyzer of blood F-800 survey These parameters from orbital venous plexus.
Table 1 Chinese medicine composition is to because of caused oligocythemic therapeutical effect of losing blood
Compare with model group: * p<0.05**p<0.01
Result shows, blood-letting mice is through taking traditional Chinese medicine composition for treating after 7 days, and 2 administration groups compare respectively at model group, and its erythrocyte is significantly higher than model group, close to normal saline group.
Two, Chinese medicine composition causes oligocythemic therapeutical effect to cyclophosphamide
1, test drug: prepare test drug according to the method for above-described embodiment 1.
2, method: to the preventive and therapeutic effect ICR mice 40 of mouse bone marrow cells hemopoietic function damage, ♀ ♂ dual-purpose, is divided into 4 groups (n=10), i.e. normal saline group, modeling group, 3g crude drug amount/kg group and 6g crude drug amount/kg, oral administration, every day 1 time.0th, except normal saline group, other respectively organized mice lumbar injection cycli phosphate amine 80mg/kg respectively, then continued administration 3 days on 5th, 10.1h after last administration, gets blood from orbital venous plexus, surveys erythrocyte, gets femur bone marrow counting number of nucleated cells.
Table 2 Chinese medicine composition is on the erythrocytic impact of caused by cyclophosphamide
Compare with normal saline group: * p<0.05**p<0.01
Result shows, compares with normal saline group, and cycli phosphate amine can make mouse bone marrow cells damage, and causes peripheral blood cells to decline, and Chinese medicine composition group compares with model group, all obviously can resist the red decline of cycli phosphate amine induced mice.
Three, Chinese medicine composition is to oligocythemic therapeutical effect caused by benzene
1, test drug: prepare test drug according to the method for above-described embodiment 1.
2, method: the impact on Induced Aplastic Anemia Mice: Kunming mouse 48, ♀ ♂ dual-purpose, is divided into 4 groups (n=12), except normal saline group, other group mouse subcutaneous injection benzene 0.5ml/kg, continuous 12 days, the same day of modeling, oral administration simultaneously, every day 1 time, totally 18 days, 1h after last administration, orbital venous plexus gets blood, surveys erythrocyte, gets femur bone marrow counting number of nucleated cells.
Table 3 Chinese medicine composition is to oligocythemic therapeutical effect caused by benzene
Compare with model group: * p<0.05**p<0.01
Result shows, 2 administration groups compare respectively at model group, all obviously can resist the erythrocytic decline of Induced Aplastic Anemia Mice caused by benzene.
Four, Chinese medicine composition is to oligocythemic therapeutical effect caused by radiation
1, test drug: prepare test drug according to the method for above-described embodiment 1.
2, method: be the therapeutical effect of research to acute radiation sickness, the Chinese medicine composition observing various dose irradiates the impact of mouse hemopoietic recovery on 6.5Gy.
Table 4 Chinese medicine composition is to oligocythemic therapeutical effect (the 10th day) caused by radiation
Compare with modeling group: * p<0.05**p<0.01
Result shows, give and being subject to according to after amount/kg, 6g crude drug amount/kg treatment of mice Chinese medicine composition every day 3g crude drug, the Restoration model of peripheral red blood cells is accelerated, and is best with 6g crude drug amount/kg dosage group effect.
Conclusion: Chinese medicine composition significantly can raise erythrocyte, can be used for preparing raising erythrocytic medicine.
Claims (3)
1. Chinese medicine composition is raising the application in erythrocyte medicine, it is characterized in that described Chinese medicine composition is prepared by the raw material of following parts by weight: Ge Xian 18 parts, horse Radix Salicis Babylonicae 20 parts, Folium Callicarpae Formosanae 15 parts, Herba Origani 12 parts, Herba Rostellulariae 20 parts.
2. Chinese medicine composition is raising the application in erythrocyte medicine as claimed in claim 1, it is characterized in that the preparation method of described Chinese medicine composition is: get above-mentioned Chinese medicine, decoct with water 2 times, amount of water is 10 times amount of medical material weight for the first time, decocts 2 hours, second time amount of water is 8 times amount of medical material weight, decoct 1 hour, collecting decoction, concentrated, dry, pulverize to obtain traditional Chinese medicine particle.
3. Chinese medicine composition is raising the application in erythrocyte medicine as claimed in claim 1, it is characterized in that in the preparation method of described Chinese medicine composition, concentrated condition is: when being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C, relative density is 1.30.Spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510216069.2A CN104800417A (en) | 2015-04-30 | 2015-04-30 | Application of traditional Chinese medicine composition for preparing medicine for increasing erythrocyte |
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| CN201510216069.2A CN104800417A (en) | 2015-04-30 | 2015-04-30 | Application of traditional Chinese medicine composition for preparing medicine for increasing erythrocyte |
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| CN201510216069.2A Withdrawn CN104800417A (en) | 2015-04-30 | 2015-04-30 | Application of traditional Chinese medicine composition for preparing medicine for increasing erythrocyte |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788758A (en) * | 2004-12-14 | 2006-06-21 | 成都地奥制药集团有限公司 | Use of traditional Chinese medicine garden burnet and its extract in preparing drug for raising red cell and blood hemoglobin |
| CN103977391A (en) * | 2014-06-11 | 2014-08-13 | 云南云龙制药股份有限公司 | Preparation method and applications of bupleurum tenue capsule |
-
2015
- 2015-04-30 CN CN201510216069.2A patent/CN104800417A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788758A (en) * | 2004-12-14 | 2006-06-21 | 成都地奥制药集团有限公司 | Use of traditional Chinese medicine garden burnet and its extract in preparing drug for raising red cell and blood hemoglobin |
| CN103977391A (en) * | 2014-06-11 | 2014-08-13 | 云南云龙制药股份有限公司 | Preparation method and applications of bupleurum tenue capsule |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
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Application publication date: 20150729 |