CN104800189B - A kind of starch plant Capsules - Google Patents
A kind of starch plant Capsules Download PDFInfo
- Publication number
- CN104800189B CN104800189B CN201510242699.7A CN201510242699A CN104800189B CN 104800189 B CN104800189 B CN 104800189B CN 201510242699 A CN201510242699 A CN 201510242699A CN 104800189 B CN104800189 B CN 104800189B
- Authority
- CN
- China
- Prior art keywords
- starch
- parts
- capsules
- capsule
- plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
- Cosmetics (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
The present invention relates to the capsule for being widely used in food, medicine and health products trade, more particularly to a kind of starch plant Capsules.Described starch plant Capsules major component by weight：50 90 parts of 50 80 parts of native starch, 10 50 parts of string and deionized water, then it is prepared using the conventional technique for preparing Capsules.Contain a variety of hydrophilic radicals in the chemical constitution for the string that the present invention adds, there is stronger retention ability so that the capsule water-retaining property of preparation is preferable.In addition, not only friability is low for starch hollow capsule made of above-mentioned raw materials, also with good disintegrating property.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of starch plant Capsules.
Background technology
Traditional gelatine capsule is made up of gelatin, G ＆ W.Due to gelatin meet aldehydes medicine easily crosslink reaction and
So that aldehydes drug inactivation, and cause gelatine capsule to fill easy moisture absorption and the drug substance contents to be reacted with capsule material.Closely
Nian Lai, " toxic capsule " constantly come into the market, and cause the fear of numerous consumers, cause the great attention of society and government.
And plant capsule is consumed because of its wide applicability, good security, stronger stability and without cross-linking reaction
Person's pursues.The plant capsule produced both at home and abroad at present has two kinds：Hydroxypropyl methylcellulose Capsules and general polysaccharide empty capsule.
But all there is the drawbacks of cost is higher, popularization is more difficult in both capsules.And starch plant Capsules has that cost is cheap, property
Advantage can be preferably waited, there is very wide application prospect.
Patent CN 103191433 disclose it is a kind of utilize plant amylum for raw material safe Capsules and its prepare work
Skill, will add 320 grams of plant amylum in 1L pure water, after stirring and dissolving, filter off the removal of impurity using hollow-fibre membrane and obtain
To plant amylum liquid, carragheen is added in 1L pure water, two kinds of solution are merged, and is stirred, is pasted in 90 DEG C of water-baths
Change, add dodecane level sodium sulfonate 0.5g, 10 parts of edible glycerol, medicinal pigment 2g, glue is dipped in after stirring, then 38-40 DEG C
1h is dried, degumming, obtains the safe Capsules of plant amylum.
Patent CN 103638001 discloses a kind of vegetative hard capsule and preparation method thereof, and the invention is by 60-80 weights
The amount modified starch of part, the thickener of 1-2 parts by weight, the plasticizer of 20-40 parts by weight mix with water, obtain dispersion liquid, will divide
Dispersion liquid dissolves by heating, and temperature control is at 70-85 DEG C, and then mould dips in glue, 40-50 DEG C of drying, cutting and fit and plant is made
Property hard shell capsules.
The content of the invention
It is an object of the invention to overcome in existing starch capsule the defects of fragility is poor, disintegration time limited is long, poor water retention property, carry
A kind of starch hollow capsule raw material components have been supplied, gelatin has been replaced using starch, not only reduces the cost of Capsules, Er Qie great
The big security for improving capsule.In addition, it with the addition of string in the capsule so that capsule has preferable retentiveness.
Invention broadly provides a kind of starch plant Capsules, mainly by native starch 50-80 parts, string
10-50 parts and deionized water 50-90 parts, then it is prepared using the conventional technique for preparing Capsules, it is characterised in that institute
The string stated is mainly selected from carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, HPMC, shaddock
One kind or combination in hide fiber element.It is preferred that shaddock ped cellulose.
Further, described starch plant Capsules, native starch be selected from rice starch, cornstarch, tapioca,
One kind or combination in sweet potato starch, pea starch, green starch.
Further, described starch plant Capsules, its component can also include plasticizer, and plasticizer is selected from edible sweet
Oil, one kind in sorbierite or combination, preferably edible glycerol.
Further, described starch plant Capsules, its component can also include carragheen, konjaku in natural plant gum
One kind or combination in glue, gellan gum, xanthans, flax gum, sesbania gum.
Further, described starch plant Capsules, video or the acceptable screening of medicine can also be included in its component
Photo etching, colouring agent, odor mask, the total amount of these additives must not exceed the 1.0% of starch hollow capsule gross weight.
Further, described starch plant Capsules, the preparation method of conventional hollow capsule can be selected and be made.It is described
The preparation method of conventional hollow capsule, it is most widely used as in industry to be stained with glue method.
Beneficial effect
（1）This starch plant Capsules with the addition of string, a variety of due to containing in the chemical constitution of string
Hydrophilic radical, there is stronger retention ability so that the capsule water-retaining property of preparation is preferable, and due to the spy of string itself
Property, into vivo itself can be with the harmful substance in adsorbent, the digestion to intestines and stomach plays a driving role.
（2）The starch plant Capsules, friability is relatively low, and disintegration time limited is shorter.
Specific embodiment
Embodiment 1
50 parts of rice starch, 10 parts of carboxymethyl cellulose are dissolved in 50 parts of deionized water, by above-mentioned raw materials mixed liquor
Starch plant Capsules is made using the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out crisp
Broken degree and disintegration time limited experiment, and investigate its water retention property.
Embodiment 2
60 parts of rice starch, 30 parts of hydroxyethyl cellulose are dissolved in 70 parts of deionized water, by above-mentioned raw materials mixed liquor
Starch plant Capsules is made using the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out crisp
Broken degree and disintegration time limited experiment, and investigate its water retention property.
Embodiment 3
80 parts of rice starch, 50 parts of carboxymethyl cellulose are dissolved in 90 parts of deionized water, by above-mentioned raw materials mixed liquor
Starch plant Capsules is made using the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out crisp
Broken degree and disintegration time limited experiment, and investigate its water retention property.
Embodiment 4
50 parts of tapioca, 10 parts of hydroxypropyl cellulose are dissolved in 60 parts of deionized water, by above-mentioned raw materials mixed liquor
Starch plant Capsules is made using the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out crisp
Broken degree and disintegration time limited experiment, and investigate its water retention property.
Embodiment 5
70 parts of tapioca, 20 parts of HPMC are dissolved in 70 parts of deionized water, above-mentioned raw materials are mixed
Starch plant Capsules is made using the preparation method of conventional hollow capsule in liquid, and prepared starch plant Capsules is carried out
Friability and disintegration time limited experiment, and investigate its water retention property.
Embodiment 6
80 parts of tapioca, 35 parts of hydroxypropyl cellulose are dissolved in 85 parts of deionized water, added into above-mentioned solution
1.5 parts of lemon yellow（Colouring agent）, starch plant is made using the preparation method of conventional hollow capsule in above-mentioned raw materials mixed liquor
Capsules, prepared starch plant Capsules carries out friability and disintegration time limited experiment, and investigates its water retention property.
Embodiment 7
55 parts of pea starch, 25 parts of carboxymethyl cellulose are dissolved in 60 parts of deionized water, by above-mentioned raw materials mixed liquor
Starch plant Capsules is made using the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out crisp
Broken degree and disintegration time limited experiment, and investigate its water retention property.
Embodiment 8
60 parts of pea starch, 40 parts of carboxymethyl cellulose are dissolved in 65 parts of deionized water, 5 are added into above-mentioned solution
Part glycerine（Plasticizer）, starch plant Capsules, institute is made using the preparation method of conventional hollow capsule in above-mentioned mixed liquor
The starch plant Capsules of preparation carries out friability and disintegration time limited experiment, and investigates its water retention property.
Embodiment 9
75 parts of pea starch, 45 parts of HPMC are dissolved in 90 parts of deionized water, above-mentioned raw materials are mixed
Starch plant Capsules is made using the preparation method of conventional hollow capsule in liquid, and prepared starch plant Capsules is carried out
Friability and disintegration time limited experiment, and investigate its water retention property.
Embodiment 10
60 parts of green starch, 45 parts of carboxymethyl cellulose are dissolved in 65 parts of deionized water, by above-mentioned raw materials mixed liquor
Starch plant Capsules is made using the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out crisp
Broken degree and disintegration time limited experiment, and investigate its water retention property.
Embodiment 11
60 parts of green starch, 45 parts of carboxymethyl cellulose are dissolved in 65 parts of deionized water, by above-mentioned raw materials mixed liquor
Starch plant Capsules is made using the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out crisp
Broken degree and disintegration time limited experiment, and investigate its water retention property.
Embodiment 12
70 parts of tapioca, 20 parts of shaddock ped cellulose are dissolved in 70 parts of deionized water, above-mentioned raw materials mixed liquor is adopted
Starch plant Capsules is made with the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out friability
Degree and disintegration time limited experiment, and investigate its water retention property.
Comparative example
55 parts of pea starch, 25 parts of carboxymethyl cellulose are dissolved in 60 parts of deionized water, by above-mentioned raw materials mixed liquor
Starch plant Capsules is made using the preparation method of conventional hollow capsule, prepared starch plant Capsules carries out crisp
Broken degree and disintegration time limited experiment, and investigate its water retention property.
Disintegration time limited tests：According to《Chinese Pharmacopoeia》2010 editions two annex carry out disintegration time limited inspection, using water as medium,
Temperature is 37 DEG C, adds baffle plate to test.Criterion is that all capsules are all disintegrated in 20min.
Friability test：According to《Chinese Pharmacopoeia》2010 editions two, starch hollow capsule 50 is taken to be put into surface plate
In the drier for filling magnesium nitrate saturated solution, 25 DEG C of ± 1 DEG C of constant temperature is put 24 hours, take out, be put into uprightly by grain respectively immediately
In glass tube on plank, circular counterweight is freely fallen at the glass mouth of pipe, whether ruptured depending on capsule, if any rupture, no
Must be more than 5.
Respectively take soft capsule made of raw material described in above-described embodiment, and appearance character to starch hollow capsule, rupture
Experiment and its disintegration time limited are detected, and the results are shown in Table 1, water retention property test result is shown in Table 2.
The starch plant Capsules friability of table 1, disintegration time limited investigate result
The starch plant Capsules water retention property of table 2 investigates result
Claims (4)
- A kind of 1. starch plant Capsules, mainly by native starch 50-80 parts, string 30-50 parts and deionized water 50- 90 parts, then it is prepared using the conventional technique for preparing Capsules, it is characterised in that described string is mainly selected from Shaddock ped cellulose, described native starch are selected from tapioca, and described Capsules is also including the carragheen in natural plant gum, evil spirit One kind or combination in taro glue, gellan gum, xanthans, flax gum, sesbania gum.
- 2. starch plant Capsules according to claim 1, it is characterised in that its component also includes plasticizer, plasticising The one kind or combination of agent in edible glycerol, sorbierite.
- 3. starch plant Capsules according to claim 2, it is characterised in that described plasticizer is selected from edible sweet Oil.
- 4. starch plant Capsules according to claim 1, it is characterised in that also include food or medicine in its component Acceptable opacifier, colouring agent, odor mask, the total amount of these additives must not exceed starch hollow capsule gross weight 1.0%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510242699.7A CN104800189B (en) | 2015-05-13 | 2015-05-13 | A kind of starch plant Capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510242699.7A CN104800189B (en) | 2015-05-13 | 2015-05-13 | A kind of starch plant Capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104800189A CN104800189A (en) | 2015-07-29 |
| CN104800189B true CN104800189B (en) | 2018-03-06 |
Family
ID=53685689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510242699.7A Active CN104800189B (en) | 2015-05-13 | 2015-05-13 | A kind of starch plant Capsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104800189B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105919978B (en) * | 2016-04-28 | 2018-03-06 | 湖南尔康制药股份有限公司 | A kind of Amoxicillin microsphere sustained-release capsule preparation method thereof |
| CN105769811A (en) * | 2016-05-05 | 2016-07-20 | 夏放军 | Empty starch capsule and preparation method thereof |
| CN105997930A (en) * | 2016-07-04 | 2016-10-12 | 安顺济世科技有限公司 | Empty capsule and soft capsule based on modified starch |
| CN108542966A (en) * | 2018-05-22 | 2018-09-18 | 湖北康科德生物科技有限公司 | A kind of hard capsule and preparation method thereof of relieving the effect of alcohol of plant formula |
| CN110090202A (en) * | 2019-06-10 | 2019-08-06 | 哈尔滨坤丰生物工程有限公司 | A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768608A (en) * | 2014-02-05 | 2014-05-07 | 许自霖 | Plant capsule composition of seaweed colloid and preparation method thereof |
| CN104056274A (en) * | 2013-03-21 | 2014-09-24 | 中国科学院化学研究所 | Reinforcing and toughening agent for preparing starch hard capsule and application thereof |
| CN104127877A (en) * | 2014-07-29 | 2014-11-05 | 浙江益立胶囊有限公司 | Plant hollow capsule |
| CN104146984A (en) * | 2014-08-07 | 2014-11-19 | 陕西科技大学 | Method for preparing hollow plant capsules from celery and starch |
| CN104398488A (en) * | 2014-11-21 | 2015-03-11 | 天津科技大学 | Chinese yam starch capsule shell containing ginger essential oil and preparation method of Chinese yam starch capsule shell |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006043284A1 (en) * | 2004-10-21 | 2006-04-27 | Sunil Mundra | A process for manufacturing neutraceutical, pharmaceutical cellulose derivatives capsule |
-
2015
- 2015-05-13 CN CN201510242699.7A patent/CN104800189B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056274A (en) * | 2013-03-21 | 2014-09-24 | 中国科学院化学研究所 | Reinforcing and toughening agent for preparing starch hard capsule and application thereof |
| CN103768608A (en) * | 2014-02-05 | 2014-05-07 | 许自霖 | Plant capsule composition of seaweed colloid and preparation method thereof |
| CN104127877A (en) * | 2014-07-29 | 2014-11-05 | 浙江益立胶囊有限公司 | Plant hollow capsule |
| CN104146984A (en) * | 2014-08-07 | 2014-11-19 | 陕西科技大学 | Method for preparing hollow plant capsules from celery and starch |
| CN104398488A (en) * | 2014-11-21 | 2015-03-11 | 天津科技大学 | Chinese yam starch capsule shell containing ginger essential oil and preparation method of Chinese yam starch capsule shell |
Non-Patent Citations (2)
| Title |
|---|
| 新型胶囊囊材-羟丙甲纤维素;张存彦，等;《中国药学杂志》;20050630;第40卷(第12期);第891-892页 * |
| 软胶囊囊壳材料的研究概况;郑文杰，等;《药学进展》;20071231;第31卷(第11期);第491-495页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104800189A (en) | 2015-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104800189B (en) | A kind of starch plant Capsules | |
| CN103893772B (en) | A kind of hydroxypropyl starch Capsules and preparation technology thereof | |
| CN104886554B (en) | Quick-fried pearl soft capsule and preparation method thereof | |
| JP5777625B2 (en) | Acid-resistant capsule | |
| EP1057862B1 (en) | Polymer film compositions for capsules | |
| AU2010358565B2 (en) | Film-forming composition for soft capsules | |
| CN104800188B (en) | A kind of preparation method of medicinal hydroxypropul starch capsule | |
| CN104324381B (en) | Starch capsule having moisturizing capability and preparation method thereof | |
| JP2552937B2 (en) | Pharmaceutical hard capsule and method for producing the same | |
| CN105997930A (en) | Empty capsule and soft capsule based on modified starch | |
| CN104721167A (en) | Starch soft capsules | |
| CN104784148B (en) | A kind of film-forming composition for preparing plant capsule and preparation method thereof | |
| CN110169955A (en) | A kind of production method of the soft capsule shell based on modified starch | |
| CN104840447A (en) | Preparation method of pulullan vacant capsules | |
| CN111040256A (en) | Raw material composition for preparing starch matrix hollow capsule and starch matrix hollow capsule | |
| CN103656655A (en) | Empty capsule and preparation method thereof | |
| CN106902093A (en) | A kind of plant enteric hollow capsule and its production method | |
| CN103055317B (en) | Instant plant soft capsule and preparation method thereof | |
| CN106729729A (en) | A kind of Capsules plant amylum composition | |
| CN109276555A (en) | A kind of labile starch base Capsules of high-ductility | |
| CN103933009B (en) | For preparing compositions and the application thereof of cellulose hard capsules | |
| CN104224747A (en) | Algae-based gastric pH response disintegrative empty capsule and preparation method thereof | |
| CN104922089A (en) | Preparation method of high-performance starch capsule | |
| CN104434870A (en) | Enteric-coated gelatine empty capsules and preparation method thereof | |
| CN103961332B (en) | A kind of composition and method of making the same preparing enteric capsulation material for replacing gelatin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |