CN110090202A - A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method - Google Patents
A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method Download PDFInfo
- Publication number
- CN110090202A CN110090202A CN201910494479.1A CN201910494479A CN110090202A CN 110090202 A CN110090202 A CN 110090202A CN 201910494479 A CN201910494479 A CN 201910494479A CN 110090202 A CN110090202 A CN 110090202A
- Authority
- CN
- China
- Prior art keywords
- parts
- pea
- capsule
- carboxy methyl
- glue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method, which belong to, to be exclusively used in drug being made the special container for taking pattern；The starch hollow capsule composition is made of 80-90 parts of pea hydroxypropyl carboxy methyl starch, 3-5 parts of gellan gum, 1-2 parts of xanthan gum and 2-3 parts of propylene glycol in parts by weight, obtains this capsule product by heating, stirring, constant temperature processing and the processing of full-automatic hard capsule production line in reaction kettle；Formula of the invention and preparation method be novel, simple, rationally, and glossiness, disintegration, the friability performance of Capsules product are good, and application performance is stablized, service performance safety, takes for drug splendid attire and provides a kind of high quality, high performance container.
Description
Technical field
The invention belongs to be exclusively used in drug being made the special container for taking pattern, a kind of pea hydroxypropyl carboxylic is related generally to
Methyl starch Capsules and preparation method.
Background technique
Currently, various plant capsules occur like the mushrooms after rain at home in capsule industry, but its quality is very different,
Service performance is of inadequate achievement, this brings huge puzzlement to the majority of consumers in use.One kind can not be found by tracing it to its cause
There is the raw material of huge advantage in terms of adaptability, safety, stability, the feature of environmental protection and reliability.Therefore, it finds and researches and develops and is a kind of steady
Fixed, healthy, environmentally friendly Capsules become current urgent need.
Summary of the invention
The purpose of the present invention is to the above-mentioned problems of the prior art, in conjunction with the practical need of current pharmaceutical production
It asks, a kind of pea hydroxypropyl carboxy methyl starch hollow capsule of researching and designing and preparation method, reaches raw material sources health, hollow glue
Capsule product glossiness, disintegration and friability are good, application performance is stable, the purpose of service performance safety and environmental protection.
The object of the present invention is achieved like this:
A kind of pea hydroxypropyl carboxy methyl starch hollow capsule, the starch hollow capsule Composition Weight Parts are as follows: pea
80-90 parts of beans hydroxypropyl carboxy methyl starch, 3-5 parts of gellan gum, 1-2 parts of xanthan gum, 2-3 parts of propylene glycol.
A kind of pea hydroxypropyl carboxy methyl starch hollow capsule preparation method, preparation step are as follows:
1., purified water is added in heating stirring reaction kettle, in parts by weight by pea hydroxypropyl carboxy methyl starch, knot it is cold
In glue, xanthan gum investment kettle, heating, stirring stop heating, constant temperature, stirring 1 hour when reactor temperature rises to 70 DEG C；
2., be added propylene glycol into reaction kettle in parts by weight, 70 DEG C of constant temperature, stirring 1.5 hours, reaction system at this time
As uniformly mixed glue；
3., glue moved in heat insulation tank, 50 DEG C of constant temperature save 4 hours it is stand-by；
4., the glue full-automatic hard capsule production line of NJ213 type, working condition is as follows: being stained with adhesive tape part: capsule cap glue bucket temperature
50.0-51.0 DEG C, 51.0 DEG C of 50.0- of capsule body glue barrel temperature of degree；Capsule cap is stained with 49.1-49.8 DEG C of glue groove temperature, and capsule body is stained with
48.1-48.9 DEG C of glue groove temperature；23.1-24.9 DEG C of room temperature；Indoor humidity 40%-45%；Drying condition: first segment 24.5-
25.5 DEG C, 25.5-26.5 DEG C of second segment, 26.5-27.5 DEG C of third section, the 4th section 27.5-28.5 DEG C, the 5th section of 27.1-28.1
DEG C, the 6th section 26.1-27.1 DEG C, the 7th section 25.1-26.1 DEG C, every time is 4.5-5.5 minutes；
5., after drying after automatic cutting and automatic body capping to get pea hydroxypropyl carboxy methyl starch hollow capsule.
The pea hydroxypropyl carboxy methyl starch and gellan gum, xanthan that the present invention is obtained after denaturation treatment using pea starch
Glue, propylene glycol compatibility complete the manufacturing of pea hydroxypropyl carboxy methyl starch hollow capsule through scientific and reasonable preparation method,
It is novel, simple, reasonable with preparation method that it is formulated, and glossiness, disintegration, the friability performance of Capsules product are good, application
Performance is stablized, and service performance safety is taken for drug splendid attire and provides a kind of high quality, high performance container.
Specific embodiment
Embodiment of the present invention is described in detail below.
A kind of pea hydroxypropyl carboxy methyl starch hollow capsule, the starch hollow capsule Composition Weight Parts are as follows: pea
80-90 parts of beans hydroxypropyl carboxy methyl starch, 3-5 parts of gellan gum, 1-2 parts of xanthan gum, 2-3 parts of propylene glycol.
A kind of pea hydroxypropyl carboxy methyl starch hollow capsule preparation method, preparation step are as follows:
1., purified water is added in heating stirring reaction kettle, in parts by weight by pea hydroxypropyl carboxy methyl starch, knot it is cold
In glue, xanthan gum investment kettle, heating, stirring stop heating, constant temperature, stirring 1 hour when reactor temperature rises to 70 DEG C；
2., be added propylene glycol into reaction kettle in parts by weight, 70 DEG C of constant temperature, stirring 1.5 hours, reaction system at this time
As uniformly mixed glue；
3., glue moved in heat insulation tank, 50 DEG C of constant temperature save 4 hours it is stand-by；
4., the glue full-automatic hard capsule production line of NJ213 type, working condition is as follows: being stained with adhesive tape part: capsule cap glue bucket temperature
50.0-51.0 DEG C, 51.0 DEG C of 50.0- of capsule body glue barrel temperature of degree；Capsule cap is stained with 49.1-49.8 DEG C of glue groove temperature, and capsule body is stained with
48.1-48.9 DEG C of glue groove temperature；23.1-24.9 DEG C of room temperature；Indoor humidity 40%-45%；Drying condition: first segment 24.5-
25.5 DEG C, 25.5-26.5 DEG C of second segment, 26.5-27.5 DEG C of third section, the 4th section 27.5-28.5 DEG C, the 5th section of 27.1-28.1
DEG C, the 6th section 26.1-27.1 DEG C, the 7th section 25.1-26.1 DEG C, every time is 4.5-5.5 minutes；
5., after drying after automatic cutting and automatic body capping to get pea hydroxypropyl carboxy methyl starch hollow capsule.
Claims (2)
1. a kind of pea hydroxypropyl carboxy methyl starch hollow capsule, it is characterised in that: the starch hollow capsule Parts by Ingredients
Number is as follows: 80-90 parts of pea hydroxypropyl carboxy methyl starch, and 3-5 parts of gellan gum, 1-2 parts of xanthan gum, 2-3 parts of propylene glycol.
2. a kind of pea hydroxypropyl carboxy methyl starch hollow capsule preparation method as described in claim 1, it is characterised in that: system
It is standby that steps are as follows:
1., purified water is added in heating stirring reaction kettle, in parts by weight by pea hydroxypropyl carboxy methyl starch, gellan gum,
Xanthan gum is put into kettle, heating, stirring, stops heating, constant temperature, stirring 1 hour when reactor temperature rises to 70 DEG C；
2., be added propylene glycol into reaction kettle in parts by weight, 70 DEG C of constant temperature, stirring 1.5 hours, reaction system becomes mixed at this time
Close uniform glue；
3., glue moved in heat insulation tank, 50 DEG C of constant temperature save 4 hours it is stand-by；
4., the glue full-automatic hard capsule production line of NJ213 type, working condition is as follows: being stained with adhesive tape part: capsule cap glue barrel temperature
50.0-51.0 DEG C, 50.0-51.0 DEG C of barrel temperature of capsule body glue；Capsule cap is stained with 49.1-49.8 DEG C of glue groove temperature, and capsule body is stained with glue
48.1-48.9 DEG C of bath temperature degree；23.1-24.9 DEG C of room temperature；Indoor humidity 40%-45%；Drying condition: first segment 24.5-25.5
DEG C, 25.5-26.5 DEG C of second segment, 26.5-27.5 DEG C of third section, the 4th section 27.5-28.5 DEG C, the 5th section 27.1-28.1 DEG C, the
Six sections 26.1-27.1 DEG C, the 7th section 25.1-26.1 DEG C, every time is 4.5-5.5 minutes；
5., after drying after automatic cutting and automatic body capping to get pea hydroxypropyl carboxy methyl starch hollow capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910494479.1A CN110090202A (en) | 2019-06-10 | 2019-06-10 | A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910494479.1A CN110090202A (en) | 2019-06-10 | 2019-06-10 | A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110090202A true CN110090202A (en) | 2019-08-06 |
Family
ID=67450553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910494479.1A Pending CN110090202A (en) | 2019-06-10 | 2019-06-10 | A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110090202A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111557925A (en) * | 2020-06-09 | 2020-08-21 | 石家庄新世纪胶囊有限公司 | Processing technology of hollow capsule body |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999052512A1 (en) * | 1998-03-27 | 1999-10-21 | Valtion Teknillinen Tutkimuskeskus | Coated starch capsules and a process for producing them |
| KR20060074755A (en) * | 2004-12-28 | 2006-07-03 | 주식회사 삼양제넥스 | Process for the production of hydroxypropyl carboxymethylated starch using dry process |
| CN103070845A (en) * | 2013-01-14 | 2013-05-01 | 北京爱特康科贸有限责任公司 | Starch hollow capsule and preparation method thereof |
| CN103834066A (en) * | 2014-03-05 | 2014-06-04 | 中国科学院青岛生物能源与过程研究所 | Low-viscosity starch glue for preparing starch capsules as well as preparation method and application of low-viscosity starch glue |
| CN104586813A (en) * | 2015-02-05 | 2015-05-06 | 湖南尔康制药股份有限公司 | All-starch plant capsules and production method thereof |
| CN104610582A (en) * | 2015-01-31 | 2015-05-13 | 湖南尔康制药股份有限公司 | All-starch plant glue as well as preparation method and application thereof |
| CN104800189A (en) * | 2015-05-13 | 2015-07-29 | 湖南尔康制药股份有限公司 | Starch plant hollow capsule |
| CN104831562A (en) * | 2015-05-05 | 2015-08-12 | 中原工学院 | Hydroxypropyl carboxymethyl waxy corn starch acid dye printing paste and preparation method |
-
2019
- 2019-06-10 CN CN201910494479.1A patent/CN110090202A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999052512A1 (en) * | 1998-03-27 | 1999-10-21 | Valtion Teknillinen Tutkimuskeskus | Coated starch capsules and a process for producing them |
| KR20060074755A (en) * | 2004-12-28 | 2006-07-03 | 주식회사 삼양제넥스 | Process for the production of hydroxypropyl carboxymethylated starch using dry process |
| CN103070845A (en) * | 2013-01-14 | 2013-05-01 | 北京爱特康科贸有限责任公司 | Starch hollow capsule and preparation method thereof |
| CN103834066A (en) * | 2014-03-05 | 2014-06-04 | 中国科学院青岛生物能源与过程研究所 | Low-viscosity starch glue for preparing starch capsules as well as preparation method and application of low-viscosity starch glue |
| CN104610582A (en) * | 2015-01-31 | 2015-05-13 | 湖南尔康制药股份有限公司 | All-starch plant glue as well as preparation method and application thereof |
| CN104586813A (en) * | 2015-02-05 | 2015-05-06 | 湖南尔康制药股份有限公司 | All-starch plant capsules and production method thereof |
| CN104831562A (en) * | 2015-05-05 | 2015-08-12 | 中原工学院 | Hydroxypropyl carboxymethyl waxy corn starch acid dye printing paste and preparation method |
| CN104800189A (en) * | 2015-05-13 | 2015-07-29 | 湖南尔康制药股份有限公司 | Starch plant hollow capsule |
Non-Patent Citations (1)
| Title |
|---|
| 李明宇，等: "羟丙基羧甲基淀粉制备工艺的优化", 《农产品加工（学刊）》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111557925A (en) * | 2020-06-09 | 2020-08-21 | 石家庄新世纪胶囊有限公司 | Processing technology of hollow capsule body |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104559829A (en) | Sticky rice wet glue added with emulsion stabilizer and preparation method thereof | |
| CN105838283B (en) | A kind of wallpaper with can high temperature packing glutinous rice glue and preparation method | |
| CN101831262A (en) | Special corn biomass-based adhesive and method for preparing same | |
| CN110090202A (en) | A kind of pea hydroxypropyl carboxy methyl starch hollow capsule and preparation method | |
| CN104804674B (en) | Environment-friendly building adhesive and preparation method thereof | |
| CN105131339A (en) | Novel edible packaging material | |
| CN106381090A (en) | Mildew-resistant and environment-friendly glutinous rice wet glue and production method thereof | |
| CN103739858A (en) | Method for preparing corn starch for talcum powder | |
| CN101486805B (en) | Preparation of calcium zinc composite stabilizer for processing plastic | |
| CN105330249A (en) | Production formula of seam beautifying agent with silver ions | |
| CN105038029A (en) | Modified PVC (polyvinyl chloride) foaming building material product and processing method thereof | |
| CN107095842A (en) | A kind of moringa seeds elite antipollution facial mask and preparation technology | |
| CN103044823B (en) | A kind of packaging plastic substrate film that contains fumarate | |
| CN110755402A (en) | Pregelatinized carboxymethyl cellulose and hollow capsule of pregelatinized carboxymethyl cellulose | |
| CN106753085A (en) | A kind of preparation method of dampproof protection against insects mounting of calligraphy and painting paste | |
| CN104263152A (en) | Heat-insulation crack-resistant titanium white paint with high adhesive force and preparation method thereof | |
| CN106666328A (en) | Mooncake preservative and preparation method thereof | |
| CN106675440A (en) | Environment-friendly wallpaper adhesive | |
| CN105524578A (en) | Bamboo product adhesive | |
| CN104306291A (en) | Liquid rouge composition and preparation method thereof | |
| CN104031572A (en) | Adhesive tape and preparation method thereof | |
| CN104119801A (en) | Preparation method of polymerized rosin glycerol ester | |
| CN104087207B (en) | A kind of medical dialyzing paper hot melt adhesive | |
| CN106833088A (en) | The preparation method of freedom from cracking function admirable powder of lacquer putty for use on | |
| CN110257194B (en) | Handmade soap with shortened saponification time and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190806 |
|
| WD01 | Invention patent application deemed withdrawn after publication |