CN104788557A - 具有减少的细胞摄取的因子viii变体 - Google Patents
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- CN104788557A CN104788557A CN201510070728.6A CN201510070728A CN104788557A CN 104788557 A CN104788557 A CN 104788557A CN 201510070728 A CN201510070728 A CN 201510070728A CN 104788557 A CN104788557 A CN 104788557A
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- 230000004001 molecular interaction Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 1
- 238000007474 nonparametric Mann- Whitney U test Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000003805 procoagulant Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- XIIOFHFUYBLOLW-UHFFFAOYSA-N selpercatinib Chemical compound OC(COC=1C=C(C=2N(C=1)N=CC=2C#N)C=1C=NC(=CC=1)N1CC2N(C(C1)C2)CC=1C=NC(=CC=1)OC)(C)C XIIOFHFUYBLOLW-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000001195 ultra high performance liquid chromatography Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10176731 | 2010-09-15 | ||
| EP10176731.7 | 2010-09-15 | ||
| US38473110P | 2010-09-21 | 2010-09-21 | |
| US61/384731 | 2010-09-21 | ||
| EP11173768 | 2011-07-13 | ||
| EP11173768.0 | 2011-07-13 | ||
| US201161507666P | 2011-07-14 | 2011-07-14 | |
| US61/507666 | 2011-07-14 | ||
| CN2011800549583A CN103209992A (zh) | 2010-09-15 | 2011-09-14 | 具有减少的细胞摄取的因子viii变体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800549583A Division CN103209992A (zh) | 2010-09-15 | 2011-09-14 | 具有减少的细胞摄取的因子viii变体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104788557A true CN104788557A (zh) | 2015-07-22 |
Family
ID=45832010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510070728.6A Pending CN104788557A (zh) | 2010-09-15 | 2011-09-14 | 具有减少的细胞摄取的因子viii变体 |
| CN2011800549583A Pending CN103209992A (zh) | 2010-09-15 | 2011-09-14 | 具有减少的细胞摄取的因子viii变体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800549583A Pending CN103209992A (zh) | 2010-09-15 | 2011-09-14 | 具有减少的细胞摄取的因子viii变体 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9321827B2 (https=) |
| EP (2) | EP2616486B1 (https=) |
| JP (2) | JP6042335B2 (https=) |
| CN (2) | CN104788557A (https=) |
| AU (1) | AU2011303916A1 (https=) |
| PL (1) | PL2616486T3 (https=) |
| WO (1) | WO2012035050A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011060371A2 (en) * | 2009-11-13 | 2011-05-19 | Puget Sound Blood Center | Factor viii t cell epitope variants having reduced immunogenicity |
| EP2841091A1 (en) | 2012-04-24 | 2015-03-04 | Novo Nordisk A/S | Pharmaceutical composition suitable for treatment of haemophilia |
| JP2015515482A (ja) | 2012-04-24 | 2015-05-28 | ノヴォ ノルディスク アー／エス | 血友病の治療に適する化合物 |
| EP2906247A1 (en) | 2012-10-15 | 2015-08-19 | Novo Nordisk Health Care AG | Factor vii conjugates |
| BR112015014753B8 (pt) | 2012-12-20 | 2020-03-03 | Basf Agro Bv | composições, uso de uma composição, método para o combate de fungos fitopatogênicos e uso dos componentes |
| UA122520C2 (uk) | 2013-01-09 | 2020-11-25 | Басф Агро Б.В. | Кристалічна форма 2-[4-(4-хлорфенокси)-2-(трифторметил)феніл]-1-(1,2,4-триазол-1-іл)пропан-2-олу, агрохімічна композиція, застосування та спосіб боротьби зі шкідливими грибами |
| WO2015003908A1 (en) | 2013-07-08 | 2015-01-15 | Basf Se | Compositions comprising a triazole compound and a biopesticide |
| EP3058066A1 (en) | 2013-10-15 | 2016-08-24 | Novo Nordisk Health Care AG | Coagulation factor vii polypeptides |
| EP3114138B1 (en) | 2014-03-05 | 2021-11-17 | Pfizer Inc. | Improved muteins of clotting factor viii |
| EA201892682A1 (ru) | 2014-06-25 | 2019-04-30 | Басф Агро Б.В. | Пестицидные композиции |
| US20200109390A1 (en) * | 2017-04-27 | 2020-04-09 | Chugai Seiyaku Kabushiki Kaisha | Coagulation factor ix with improved pharmacokinetics |
| US12252528B2 (en) | 2018-10-23 | 2025-03-18 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating Factor VIII function |
| BR112021019959A2 (pt) | 2019-04-17 | 2022-02-08 | Novo Nordisk As | Anticorpo biespecífico, e, formulação farmacêutica |
| WO2021224369A1 (en) * | 2020-05-08 | 2021-11-11 | UCB Biopharma SRL | Arrays and methods for identifying binding sites on a protein |
| CN113248594B (zh) * | 2021-04-26 | 2022-08-30 | 北京美康基免生物科技有限公司 | 一种重组凝血因子viii及其应用 |
| WO2025164792A1 (ja) * | 2024-02-02 | 2025-08-07 | 学校法人自治医科大学 | 高比活性／高分泌発現型の第ｖｉｉｉ因子改変体、高発現型の第ｖｉｉｉ因子コード核酸及びそれらの用途 |
| WO2025168826A1 (en) | 2024-02-08 | 2025-08-14 | Hemab Aps | Methods of treating coagulopathy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101724075A (zh) * | 2001-10-10 | 2010-06-09 | 诺和诺德公司 | 肽的重构和糖缀合 |
| CN101778937A (zh) * | 2007-06-04 | 2010-07-14 | 诺和诺德公司 | 使用n-乙酰葡糖胺转移酶的o-联糖基化 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2645588A (en) | 1987-12-04 | 1989-06-15 | Scripps Clinic And Research Foundation | The von willebrand factor binding domain of factor viii |
| SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| AU6029594A (en) * | 1993-01-15 | 1994-08-15 | Enzon, Inc. | Factor viii - polymeric conjugates |
| SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| WO1999055377A2 (en) | 1998-04-28 | 1999-11-04 | Applied Research Systems Ars Holding N.V. | Polyol-ifn-beta conjugates |
| US6759216B1 (en) | 1998-11-06 | 2004-07-06 | Emory University | Glycosylated, low antigenicity low immunogenicity factor VIII |
| EP1129186B2 (de) | 1998-11-10 | 2016-11-30 | Stichting Sanquin Bloedvoorziening | Ein faktor viii-polypeptid mit faktor viii:c-aktivität |
| AU2002352524B2 (en) * | 2001-11-07 | 2007-10-04 | Nektar Therapeutics | Branched polymers and their conjugates |
| AU2002364509A1 (en) * | 2001-11-30 | 2003-06-17 | Emory University | Factor viii c2 domain variants |
| DE60332011D1 (de) | 2002-04-29 | 2010-05-20 | Sanquin Bloedvoorziening | Antagonisten der interaktion zwischen faktor viii und lrp ("low-density lipoprotein receptor related protein") |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| WO2008025856A2 (en) | 2006-09-01 | 2008-03-06 | Novo Nordisk Health Care Ag | Modified glycoproteins |
| KR101582841B1 (ko) | 2008-02-27 | 2016-01-11 | 노보 노르디스크 에이/에스 | 콘쥬게이트된 인자 ｖｉｉｉ 분자 |
| WO2011060371A2 (en) | 2009-11-13 | 2011-05-19 | Puget Sound Blood Center | Factor viii t cell epitope variants having reduced immunogenicity |
-
2011
- 2011-09-14 EP EP11769805.0A patent/EP2616486B1/en not_active Not-in-force
- 2011-09-14 CN CN201510070728.6A patent/CN104788557A/zh active Pending
- 2011-09-14 EP EP18195448.8A patent/EP3466968A1/en not_active Withdrawn
- 2011-09-14 JP JP2013528649A patent/JP6042335B2/ja not_active Expired - Fee Related
- 2011-09-14 WO PCT/EP2011/065913 patent/WO2012035050A2/en not_active Ceased
- 2011-09-14 US US13/822,942 patent/US9321827B2/en not_active Expired - Fee Related
- 2011-09-14 AU AU2011303916A patent/AU2011303916A1/en not_active Abandoned
- 2011-09-14 CN CN2011800549583A patent/CN103209992A/zh active Pending
- 2011-09-14 PL PL11769805T patent/PL2616486T3/pl unknown
-
2015
- 2015-09-23 US US14/862,934 patent/US20160002314A1/en not_active Abandoned
-
2016
- 2016-07-07 JP JP2016134866A patent/JP6336522B2/ja not_active Expired - Fee Related
- 2016-11-18 US US15/355,475 patent/US10047142B2/en active Active
-
2018
- 2018-07-06 US US16/028,603 patent/US10906960B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101724075A (zh) * | 2001-10-10 | 2010-06-09 | 诺和诺德公司 | 肽的重构和糖缀合 |
| CN101778937A (zh) * | 2007-06-04 | 2010-07-14 | 诺和诺德公司 | 使用n-乙酰葡糖胺转移酶的o-联糖基化 |
Non-Patent Citations (2)
| Title |
|---|
| HENRIET MEEMS等: "Factor VIII C1domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity", <BLOOD> * |
| LIN JASPER C等: "Six Amino Acid residues in a 1200 angstrom(2)interface mediate binding of factor VIII to an IgG4 inhibitory antibody", <BLOOD> * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016180002A (ja) | 2016-10-13 |
| US20180327479A1 (en) | 2018-11-15 |
| WO2012035050A3 (en) | 2012-06-14 |
| JP6042335B2 (ja) | 2016-12-14 |
| EP2616486A2 (en) | 2013-07-24 |
| CN103209992A (zh) | 2013-07-17 |
| US20170066813A1 (en) | 2017-03-09 |
| US9321827B2 (en) | 2016-04-26 |
| JP6336522B2 (ja) | 2018-06-06 |
| AU2011303916A1 (en) | 2013-03-21 |
| JP2013541521A (ja) | 2013-11-14 |
| US10906960B2 (en) | 2021-02-02 |
| US10047142B2 (en) | 2018-08-14 |
| WO2012035050A2 (en) | 2012-03-22 |
| US20160002314A1 (en) | 2016-01-07 |
| US20140057848A1 (en) | 2014-02-27 |
| PL2616486T3 (pl) | 2019-05-31 |
| EP2616486B1 (en) | 2019-01-02 |
| EP3466968A1 (en) | 2019-04-10 |
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