CN104783299A - Compound natural antioxidant for keratin preparation and preparation method of nanoemulsion of compound natural antioxidant - Google Patents
Compound natural antioxidant for keratin preparation and preparation method of nanoemulsion of compound natural antioxidant Download PDFInfo
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- CN104783299A CN104783299A CN201510129508.6A CN201510129508A CN104783299A CN 104783299 A CN104783299 A CN 104783299A CN 201510129508 A CN201510129508 A CN 201510129508A CN 104783299 A CN104783299 A CN 104783299A
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- 102000011782 Keratins Human genes 0.000 title claims abstract description 42
- 108010076876 Keratins Proteins 0.000 title claims abstract description 42
- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 13
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 13
- 150000001875 compounds Chemical class 0.000 title abstract description 10
- 229930003935 flavonoid Natural products 0.000 claims abstract description 12
- 150000002215 flavonoids Chemical class 0.000 claims abstract description 12
- 235000017173 flavonoids Nutrition 0.000 claims abstract description 12
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000004676 glycans Chemical class 0.000 claims abstract description 6
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 6
- 239000005017 polysaccharide Substances 0.000 claims abstract description 6
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 6
- 239000011719 vitamin A Substances 0.000 claims abstract description 6
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 6
- 239000011709 vitamin E Substances 0.000 claims abstract description 6
- 239000002131 composite material Substances 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 24
- 230000008569 process Effects 0.000 claims description 23
- -1 EDDS ester Chemical class 0.000 claims description 14
- 229930003231 vitamin Natural products 0.000 claims description 13
- 235000013343 vitamin Nutrition 0.000 claims description 13
- 239000011782 vitamin Substances 0.000 claims description 13
- 229940088594 vitamin Drugs 0.000 claims description 13
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 13
- 239000002738 chelating agent Substances 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 229940071087 ethylenediamine disuccinate Drugs 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 8
- 241001061264 Astragalus Species 0.000 claims description 8
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 8
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 8
- BPYGTFFYYOWDBC-LOVSFRALSA-N arctiin Natural products COc1ccc(C[C@H]2COC(=O)[C@@H]2Cc3ccc(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c3)cc1OC BPYGTFFYYOWDBC-LOVSFRALSA-N 0.000 claims description 8
- 235000006533 astragalus Nutrition 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 8
- 210000004233 talus Anatomy 0.000 claims description 8
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims description 7
- 241000723353 Chrysanthemum Species 0.000 claims description 7
- 235000007516 Chrysanthemum Nutrition 0.000 claims description 7
- 241001672694 Citrus reticulata Species 0.000 claims description 7
- GCPYCNBGGPHOBD-UHFFFAOYSA-N Delphinidin Natural products OC1=Cc2c(O)cc(O)cc2OC1=C3C=C(O)C(=O)C(=C3)O GCPYCNBGGPHOBD-UHFFFAOYSA-N 0.000 claims description 7
- GQODBWLKUWYOFX-UHFFFAOYSA-N Isorhamnetin Natural products C1=C(O)C(C)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 GQODBWLKUWYOFX-UHFFFAOYSA-N 0.000 claims description 7
- IKGXIBQEEMLURG-UHFFFAOYSA-N Rutin Chemical compound OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-UHFFFAOYSA-N 0.000 claims description 7
- 229930014669 anthocyanidin Natural products 0.000 claims description 7
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims description 7
- 235000008758 anthocyanidins Nutrition 0.000 claims description 7
- JKHRCGUTYDNCLE-UHFFFAOYSA-O delphinidin Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC(O)=C(O)C(O)=C1 JKHRCGUTYDNCLE-UHFFFAOYSA-O 0.000 claims description 7
- 235000007242 delphinidin Nutrition 0.000 claims description 7
- AIONOLUJZLIMTK-AWEZNQCLSA-N hesperetin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-AWEZNQCLSA-N 0.000 claims description 7
- AIONOLUJZLIMTK-UHFFFAOYSA-N hesperetin Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-UHFFFAOYSA-N 0.000 claims description 7
- 229960001587 hesperetin Drugs 0.000 claims description 7
- 235000010209 hesperetin Nutrition 0.000 claims description 7
- FTODBIPDTXRIGS-UHFFFAOYSA-N homoeriodictyol Natural products C1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 FTODBIPDTXRIGS-UHFFFAOYSA-N 0.000 claims description 7
- 229940005608 hypericin Drugs 0.000 claims description 7
- PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 claims description 7
- 235000008800 isorhamnetin Nutrition 0.000 claims description 7
- IZQSVPBOUDKVDZ-UHFFFAOYSA-N isorhamnetin Chemical compound C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 IZQSVPBOUDKVDZ-UHFFFAOYSA-N 0.000 claims description 7
- 229940070765 laurate Drugs 0.000 claims description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 7
- 235000013824 polyphenols Nutrition 0.000 claims description 7
- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 claims description 7
- MPJQXAIKMSKXBI-UHFFFAOYSA-N 2,7,9,14-tetraoxa-1,8-diazabicyclo[6.6.2]hexadecane-3,6,10,13-tetrone Chemical compound C1CN2OC(=O)CCC(=O)ON1OC(=O)CCC(=O)O2 MPJQXAIKMSKXBI-UHFFFAOYSA-N 0.000 claims description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 5
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 5
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 239000008267 milk Substances 0.000 claims description 5
- 210000004080 milk Anatomy 0.000 claims description 5
- 235000013336 milk Nutrition 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 5
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 5
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims description 5
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims description 5
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims description 5
- 235000005493 rutin Nutrition 0.000 claims description 5
- 229960004555 rutoside Drugs 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- 239000008158 vegetable oil Substances 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 229940045997 vitamin a Drugs 0.000 claims description 5
- 230000004048 modification Effects 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 3
- 238000006065 biodegradation reaction Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims description 2
- 244000241838 Lycium barbarum Species 0.000 claims description 2
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 2
- 241000241413 Propolis Species 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 229940067597 azelate Drugs 0.000 claims description 2
- 229960003237 betaine Drugs 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 2
- 229940069949 propolis Drugs 0.000 claims description 2
- 230000009467 reduction Effects 0.000 claims description 2
- 235000013616 tea Nutrition 0.000 claims description 2
- BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 claims 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 abstract description 10
- 238000006460 hydrolysis reaction Methods 0.000 abstract description 10
- 102000004169 proteins and genes Human genes 0.000 abstract description 6
- 108090000623 proteins and genes Proteins 0.000 abstract description 6
- 230000003647 oxidation Effects 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract 1
- 235000019154 vitamin C Nutrition 0.000 abstract 1
- 239000011718 vitamin C Substances 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 238000005238 degreasing Methods 0.000 description 5
- MPGWGYQTRSNGDD-UHFFFAOYSA-N hypericin Chemical compound OC1=CC(O)=C(C2=O)C3=C1C1C(O)=CC(=O)C(C4=O)=C1C1=C3C3=C2C(O)=CC(C)=C3C2=C1C4=C(O)C=C2C MPGWGYQTRSNGDD-UHFFFAOYSA-N 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- 210000000085 cashmere Anatomy 0.000 description 4
- 210000000050 mohair Anatomy 0.000 description 4
- 210000002268 wool Anatomy 0.000 description 4
- QEDXSHCYPROEOK-UHFFFAOYSA-N 3-phosphanylpropanoic acid Chemical compound OC(=O)CCP QEDXSHCYPROEOK-UHFFFAOYSA-N 0.000 description 3
- 235000016068 Berberis vulgaris Nutrition 0.000 description 3
- 241000335053 Beta vulgaris Species 0.000 description 3
- 241000235342 Saccharomycetes Species 0.000 description 3
- 241001655322 Streptomycetales Species 0.000 description 3
- 239000000919 ceramic Substances 0.000 description 3
- 238000010612 desalination reaction Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000001307 helium Substances 0.000 description 3
- 229910052734 helium Inorganic materials 0.000 description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 3
- 235000003642 hunger Nutrition 0.000 description 3
- 108010059345 keratinase Proteins 0.000 description 3
- 238000001471 micro-filtration Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000037351 starvation Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000003026 anti-oxygenic effect Effects 0.000 description 1
- 229940058307 antinematodal tetrahydropyrimidine derivative Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000000864 peroxy group Chemical group O(O*)* 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
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Classifications
-
- A23L3/3562—
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/10—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from hair, feathers, horn, skins, leather, bones, or the like
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a compound natural antioxidant for keratin preparation and a preparation method of nanoemulsion of the compound natural antioxidant. The compound natural antioxidant comprises flavonoid, polysaccharide active matter, and one or more of vitamins A, C and E extracted from natural plants, and reduced glutathione-S-monoether. The compound natural antioxidant is further prepared into the nanoemulsion with high solubility in water, is applied to a keratin preparation technology and has the advantages of environmental protection and high oxidation resistance; furthermore, ingredient structures of the compound natural antioxidant are complete and reasonable; and the compound natural antioxidant has strong synergism, and can carry out oxidation protection during the whole course from a hydrolysis production process of keratin to a protein product to ensure safety and sanitation of the protein product from beginning to end.
Description
Technical field
The invention belongs to antioxidant technology field, particularly a kind of composite natural of preparing for keratin and nano-emulsion preparation method thereof.
Background technology
From animal hair, fowl feather etc., extract keratin be used as feed or health nutrient, make it turn waste into wealth, this technology is more welcome, but still Problems existing is at present, protein product obtained by existing technology, its hygienic quality is reliable and stable not enough, particularly adds to and still can not make us very relieved in food.Trace it to its cause is that keratin often Mei Lade side reaction can occur in hydrolysis; this Mei Lade side reaction is the root that toxin produces; wherein various free radical such as hydroxy radical, peroxy and single linear oxygen etc. can derive again hundreds of kind toxicant, and therefore control and cancellation free radical have become to eliminate the important step that toxin improves protein product hygienic quality.
Summary of the invention
The first object of the present invention is to provide a kind of composite natural prepared for keratin, with the various free radicals effectively controlled and cancellation keratin produces when being hydrolyzed; The second object of the present invention is to provide and is a kind ofly prepared into nano-emulsion method by being used for composite natural prepared by keratin.
The technical solution realizing above-mentioned purpose is:
For a composite natural prepared by keratin, comprise the glutathione-S-monoether of one or more and the reduction in the flavonoids of extracted form natural plant, active polysaccharide thing, vitamin A, C, E.
As preferably, also comprise Superoxide dismutase/glutathione-S-ether/vitamin A race or C race, E race built agent and EDDS ester chelating agent.
As preferably, described flavonoids, active polysaccharide thing comprise anthocyanidin, delphinidin, Tea Polyphenols, mandarin orange hesperetin, forulic acid, hypericin, isorhamnetin, carrotene, Arctiin, chrysanthemum extract, matrimony vine, propolis and astragalus polyose.
As preferably, also comprise vitamin, acidylate ester that flavonoids modification becomes or flavonoids, cellulose conjugate.
As preferably, the acidylate ester that described vitamin, flavonoids modification become comprises vitamin C-laurate, forulic acid-1-glyceride, phytomelin azelate.
As preferably, be also added with biodegradation chelating agent ethylenediamine disuccinate.
As preferably, comprising: Superoxide dismutase/glutathione-S-ether/vitamin E race built agent 38-58% and EDDS ester chelating agent 1-5wt%, mandarin orange hesperetin 4-6wt%; Anthocyanidin 3-5wt%, delphinidin 6-8wt%, isorhamnetin 0.5-1wt%, chrysanthemum extract 2-3wt%, Tea Polyphenols 2-3wt%, carrotene 4-6wt%, vitamin C-laurate 4-6wt%, forulic acid-1-glyceride 6-8wt%, arctiin 0.3-0.8wt%, astragalus polyose 6-10wt%, hypericin rutin sophorin 3-5wt% and ethylene diamine disuccinate 0.15wt%.
A preparation method for the nano-emulsion of the composite natural prepared for keratin as claimed in claim 1, comprises the following steps: material rate is
1) in 50ml deionized water, add phosphate and allot the cushioning liquid that pH value is 7-7.5, add coamidopropyl betaine 200g, 40-60 DEG C of process 3-8min in homogenizer;
2) complete for sterilization milk 400-600ml, ethanol 400-600ml, Tween-20 20-30g are added in homogenizer, 40-60 DEG C of process 3-8min;
3) composite natural 19-22g is added in vegetable oil 1200-1300ml, being placed in homogenizer 40-55 DEG C, stirring 10-20min, then by step 2) gained mixture is added in step 1) gained mixture, be placed in homogenizer, at 40-60 DEG C of temperature, process 5-15min;
4) in step 3) gained mixed liquor, add EDDS ester 140-160mg, be placed in nanometer emulsified device, at 30-50 DEG C of temperature, process 15-30min, break into nano-emulsion.
As preferably, the particle diameter of described nano-emulsion is 800-950nm.
A kind of composite natural prepared for keratin is preparing the application as antioxidant in keratin powder.
Advantageous Effects of the present invention:
1, the composite natural prepared for keratin provided by the present invention, its each component energy synergism synergy mutually, greatly strengthen and improve comprehensive oxidation resistance, such as the synergism of flavonoids, polysaccharide isoreactivity thing and vitamin is composite, can the effective various free radical of cancellation, aldehyde, ketone and the alcohol that may generate Oxidation of Fat and Oils and brown stain have obvious inhibitory action, thus effectively suppress the Maillard reaction in keratoprotein hydrolytic process; Wherein to put forward the composite then synergism of EGCG, astragalus polyose, arctiin and vitamin obvious for tea, can effectively suppress peroxide anion O2-and H2O2, it up to 90wt%, to the inhibiting rate of MDA up to 95wt%, and can provide significant reducing power to free radical scavenging activity; The synergism synergy of Superoxide dismutase/glutathione-S-ether/vitamin A race, C race, E race built agent and EDDS ester chelating agent effectively can suppress the formation of keratin hydrolysis poison byproduct tetrahydropyrimidinederivatives derivatives.
2, this can to production process to the omnidistance anti-oxidation protection of product for composite natural prepared by keratin; because the most of natural in composite natural is cleared up completely in keratin hydrolysis process; but there are partially acylated ester or fiber conjugate derivative to clear up and to be retained in keratinous-protein product; the a small amount of free radical produce in very long transport, storage and marketing process protein product and toxicant continue to play anti-oxidant virus killing effect, to guarantee protein product safety and sanitation from start to finish.
3, this is used for also including ethylenediamine disuccinate in the composite natural prepared of keratin, and it belongs to the chelating agent of biological easily degraded, and it is in natural surroundings, at the most 54 days just can be degradable.Relatively conventional chelating agent EDTA etc., biodegradation rate is fast and thorough, so the relatively safer environmental protection of the present invention.
4, because natural is water-soluble poor, in order to increase antioxygenic effect, its composition is made the nanoemulsions that particle diameter is 800-950nm by the present invention, thus substantially increases the solubility of compound antioxidant active compound.
Detailed description of the invention
With specific embodiment, the present invention will be further described below, therefore do not limit the present invention among described scope of embodiments.
Embodiment 1
For composite natural A prepared by keratin, comprise Superoxide dismutase/glutathione-S-ether/vitamin E race built agent 38 wt % and EDDS ester chelating agent 5wt%, mandarin orange hesperetin 4wt%; Anthocyanidin 5wt%, delphinidin 6wt%, isorhamnetin 1wt%, chrysanthemum extract 2wt%, Tea Polyphenols 3wt%, carrotene 4wt%, vitamin C-laurate 6wt%, forulic acid-1-glyceride 6wt%, arctiin 0.8wt%, astragalus polyose 6wt%, hypericin rutin sophorin 5wt% and ethylene diamine disuccinate 0.15 wt%.
Embodiment 2
For composite natural B prepared by keratin, comprise Superoxide dismutase/glutathione-S-ether/vitamin E race built agent 58 wt % and EDDS ester chelating agent 1wt%, mandarin orange hesperetin 6wt%; Anthocyanidin 3wt%, delphinidin 8wt%, isorhamnetin 0.5wt%, chrysanthemum extract 3wt%, Tea Polyphenols 2wt%, carrotene 6wt%, vitamin C-laurate 4wt%, forulic acid-1-glyceride 8wt%, arctiin 0.3wt%, astragalus polyose 10wt%, hypericin rutin sophorin 3wt% and ethylene diamine disuccinate 0.15 wt%.
Embodiment 3
For composite natural C prepared by keratin, comprise Superoxide dismutase/glutathione-S-ether/vitamin E race built agent 48 wt % and EDDS ester chelating agent 3wt%, mandarin orange hesperetin 5wt%; Anthocyanidin 4wt%, delphinidin 7wt%, isorhamnetin 0.8wt%, chrysanthemum extract 2.5wt%, Tea Polyphenols 2.5wt%, carrotene 5wt%, vitamin C-laurate 5wt%, forulic acid-1-glyceride 7wt%, arctiin 0.6wt%, astragalus polyose 8wt%, hypericin rutin sophorin 4wt% and ethylene diamine disuccinate 0.15 wt%.
Embodiment 4, the nano-emulsion A for the preparation of composite natural prepared by keratin:
1) in 50ml deionized water, add phosphate and allot the cushioning liquid that pH value is 7, add coamidopropyl beet 200g, 60 DEG C of process 3min in homogenizer;
2) complete for sterilization milk 400ml, ethanol 400ml, Tween-20 20g are added in homogenizer, 60 DEG C of process 3min;
3) composite natural A 20.44g being added in vegetable oil 1260ml, is placed in homogenizer 55 DEG C, stir 10min, then by step 2) gained mixture is added in step 1) gained mixture, is placed in homogenizer, at 60 DEG C of temperature, processes 5min;
4) in step 3) gained mixed liquor, add EDDS ester 150mg, be placed in nanometer emulsified device, at 50 DEG C of temperature, process 15min, break into 800nm nano-emulsion.
Embodiment 5, the nano-emulsion B for the preparation of composite natural prepared by keratin:
1) in 50ml deionized water, add phosphate and allot the cushioning liquid that pH value is 7.5, add coamidopropyl beet 200g, 40 DEG C of process 8min in homogenizer;
2) complete for sterilization milk 400ml, ethanol 600ml, Tween-20 30g are added in homogenizer, 40 DEG C of process 8min;
3) composite natural B 19g being added in vegetable oil 1200ml, is placed in homogenizer 40 DEG C, stir 20min, then by step 2) gained mixture is added in step 1) gained mixture, is placed in homogenizer, at 40 DEG C of temperature, processes 15min;
4) in step 3) gained mixed liquor, add EDDS ester 160mg, be placed in nanometer emulsified device, at 30 DEG C of temperature, process 30min, break into nanometer 880nm breast.
Embodiment 6, the nano-emulsion C for the preparation of composite natural prepared by keratin:
1) in 50ml deionized water, add phosphate and allot the cushioning liquid that pH value is 7, add coamidopropyl beet 200g, 60 DEG C of process 5min in homogenizer;
2) complete for sterilization milk 600ml, ethanol 400ml, Tween-20 25g are added in homogenizer, 50 DEG C of process 5min;
3) composite natural C 22g being added in vegetable oil 1300ml, is placed in homogenizer 45 DEG C, stir 15min, then by step 2) gained mixture is added in step 1) gained mixture, is placed in homogenizer, at 50 DEG C of temperature, processes 10min;
4) in step 3) gained mixed liquor, add EDDS ester 140mg, be placed in nanometer emulsified device, at 40 DEG C of temperature, process 25min, break into 950nm nano-emulsion
Embodiment 7, for the application of composite natural nano-emulsion in the preparation of mohair yarn keratin prepared by keratin
1) degreasing
Take mohair yarn as raw material, the mohair yarn cleaned out first is carried out ungrease treatment;
2) enzymolysis
Get by streptomycete keratinase (80,000 active unit) 1.8 grams per liters, saccharomycete enzyme (pure content is 98%) 2.0 grams per liters, three (2-carboxyethyl) phosphine 0.09 grams per liter, the complex enzyme hydrolysis reagent of ethylenediamine disuccinate 0.6 grams per liter, add the nano-emulsion A1.8 grams per liter of composite natural prepared by embodiment 4 simultaneously, adjust ph is 4, degreasing mohair yarn 100kg is added wherein (namely in 600 premium on currency, add the nano-emulsion A of the complex enzyme hydrolysis reagent of 2694 grams and the composite natural of 1080 grams, in room temperature also with pretreatment 25min under helium starvation condition, adjust ph is 6.5 again, control temperature is 60 DEG C, enzymolysis 12 hours, obtain enzymolysis liquid,
3) enzymolysis liquid is adopted the desalination of ceramic micron openings micro-filtration;
4) sterilizing, drying
Obtained albumen powder, after testing, in albumen powder, the content of albumen is 95.5wt%, and sanitary quality index reaches ISO11290 standard-required.
Embodiment 8, the composite application of composite natural nano-emulsion in wool keratin preparation prepared for keratin
1) degreasing
Take wool as raw material, the wool cleaned out first is carried out ungrease treatment;
2) enzymolysis
Get by streptomycete keratinase (80,000 active unit) 1.8 grams per liters, saccharomycete enzyme (pure content is 98%) 2.0 grams per liters, three (2-carboxyethyl) phosphine 0.09 grams per liter, the complex enzyme hydrolysis reagent of ethylenediamine disuccinate 0.6 grams per liter, add nano-emulsion 1.5 grams per liter of composite natural prepared by embodiment 5 simultaneously, (namely in 600 premium on currency, the nano-emulsion B adjust ph of adding the complex enzyme hydrolysis reagent of 2694 grams and the composite natural of 900 grams is 5, steeping wool 100kg is added wherein, in room temperature also with pretreatment 25min under helium starvation condition, adjust ph is 7.5 again, control temperature is 50 DEG C, enzymolysis 24 hours, obtain enzymolysis liquid,
3) enzymolysis liquid is adopted the desalination of ceramic micron openings micro-filtration;
4) sterilizing, drying
Obtained albumen powder, after testing, in albumen powder, the content of albumen is 95.1wt%, and sanitary quality index reaches ISO11290 standard-required.
Embodiment 9, the composite application of composite natural nano-emulsion in the preparation of cashmere keratin prepared for keratin
1) degreasing
Take cashmere as raw material, the cashmere cleaned out first is carried out ungrease treatment;
2) enzymolysis
Get by streptomycete keratinase (80,000 active unit) 1.8 grams per liters, saccharomycete enzyme (pure content is 98%) 2.0 grams per liters, three (2-carboxyethyl) phosphine 0.09 grams per liter, the complex enzyme hydrolysis reagent of ethylenediamine disuccinate 0.6 grams per liter, add nano-emulsion 1.6 grams per liter of composite natural prepared by embodiment 6 simultaneously, (namely in 600 premium on currency, the nano-emulsion C adjust ph of adding the complex enzyme hydrolysis reagent of 2694 grams and the composite natural of 960 grams is 4.5, degreasing cashmere 100kg is added wherein, in room temperature also with pretreatment 20min under helium starvation condition, adjust ph is 7 again, control temperature is 55 DEG C, enzymolysis 20 hours, obtain enzymolysis liquid,
3) enzymolysis liquid is adopted the desalination of ceramic micron openings micro-filtration;
4) sterilizing, drying
Obtained albumen powder, after testing, in albumen powder, the content of albumen is 94.5wt%, and sanitary quality index reaches ISO11290 standard-required.
Claims (10)
1., for a composite natural prepared by keratin, it is characterized in that comprising the glutathione-S-monoether of one or more and the reduction in the flavonoids of extracted form natural plant, active polysaccharide thing, vitamin A, C, E.
2. the composite natural prepared for keratin according to claim 1, characterized by further comprising Superoxide dismutase/glutathione-S-ether/vitamin A race or C race, E race built agent and EDDS ester chelating agent.
3. the composite natural prepared for keratin according to claim 1, it is characterized in that described flavonoids, active polysaccharide thing comprise anthocyanidin, delphinidin, Tea Polyphenols, mandarin orange hesperetin, forulic acid, hypericin, isorhamnetin, carrotene, Arctiin, chrysanthemum extract, matrimony vine, propolis and astragalus polyose.
4. the composite natural prepared for keratin according to claim 1 and 2, characterized by further comprising vitamin, flavonoids modification become acidylate ester or flavonoids, cellulose conjugate.
5. composite natural according to claim 4, it is characterized in that described vitamin, flavonoids modification become acidylate ester comprise vitamin C-laurate, forulic acid-1-glyceride, phytomelin azelate.
6. the composite natural prepared for keratin according to claim 4, is characterized in that also being added with biodegradation chelating agent ethylenediamine disuccinate.
7. the composite natural prepared for keratin according to claim 6, it is characterized in that comprising: Superoxide dismutase/glutathione-S-ether/vitamin E race built agent 38-58% and EDDS ester chelating agent 1-5wt%, mandarin orange hesperetin 4-6wt%; Anthocyanidin 3-5wt%, delphinidin 6-8wt%, isorhamnetin 0.5-1wt%, chrysanthemum extract 2-3wt%, Tea Polyphenols 2-3wt%, carrotene 4-6wt%, vitamin C-laurate 4-6wt%, forulic acid-1-glyceride 6-8wt%, arctiin 0.3-0.8wt%, astragalus polyose 6-10wt%, hypericin rutin sophorin 3-5wt% and ethylene diamine disuccinate 0.15 wt%.
8. a preparation method for the nano-emulsion of the composite natural prepared for keratin as claimed in claim 1, is characterized in that, comprise the following steps: material rate is
1) in 50ml deionized water, add phosphate and allot the cushioning liquid that pH value is 7-7.5, add coamidopropyl betaine 200g, 40-60 DEG C of process 3-8min in homogenizer;
2) complete for sterilization milk 400-600ml, ethanol 400-600ml, Tween-20 20-30g are added in homogenizer, 40-60 DEG C of process 3-8min;
3) composite natural 19-22g is added in vegetable oil 1200-1300ml, being placed in homogenizer 40-55 DEG C, stirring 10-20min, then by step 2) gained mixture is added in step 1) gained mixture, be placed in homogenizer, at 40-60 DEG C of temperature, process 5-15min;
4) in step 3) gained mixed liquor, add EDDS ester 140-160mg, be placed in nanometer emulsified device, at 30-50 DEG C of temperature, process 15-30min, break into nano-emulsion.
9. the preparation method of the nano-emulsion of the composite natural prepared for keratin according to claim 8, is characterized in that the particle diameter of described nano-emulsion is 800-950nm.
10. the composite natural nano-emulsion prepared for keratin that method obtains as claimed in claim 8 is preparing the application as antioxidant in keratin powder.
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| CN114249981A (en) * | 2021-12-20 | 2022-03-29 | 杭州电子科技大学 | Preparation method of wool keratin/brown algae polyphenol composite nano material |
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| WO2013070798A2 (en) * | 2011-11-07 | 2013-05-16 | Mars, Incorporated | Food protein ingredient and methods for producing |
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| CN114249981A (en) * | 2021-12-20 | 2022-03-29 | 杭州电子科技大学 | Preparation method of wool keratin/brown algae polyphenol composite nano material |
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