CN104771423A - Method for preparing medicament for treating facial neuritis and corresponding medicament - Google Patents
Method for preparing medicament for treating facial neuritis and corresponding medicament Download PDFInfo
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Abstract
The invention provides a method for preparing a medicament for treating facial neuritis. The method adopts 4-8 parts of centipede, 8-12 parts of ceramic powder, 3-5 parts of azone, 80-120 parts of massicot and 180-220 parts of sesame oil as raw materials, is low in cost and good in effect, and compared with a conventional facial neuritis treatment manner, the medicament can eliminate pain from patients of all stages in a shorter time. The medicament prepared by the method provided by the invention has a treatment cycle of only 1-9 days for early onset patients, and the effective rate of the medicament reaches 100% which is significantly higher than that of about 90% of conventional treatment; and moreover, for the patients with sequelae of the facial neuritis, the medicament provided by the invention can achieve the aim of treatment by activating necrosis nerves, the effective rate reaches more than 80%, and the final conclusion that the patient with the facial neuritis can only be cured by virtue of operative treatment if the course of disease is more than 6 months is broken through.
Description
Technical field
The present invention relates to Chinese medicine, in particular to a kind of preparation method and the relative medicine that are used for the treatment of the medicine of facial neuritis.
Background technology
Facial paralysis, is commonly called as facial neuritis, " facial paralysis ", is a kind of commonly encountered diseases that is principal character with facial expression muscle group dyskinesia.General symptom is facial hemiparalysis.It is a kind of commonly encountered diseases, frequently-occurring disease, and it is not by age limit.Patient is often the most basic to lift the actions such as eyebrow, eye closing, drum mouth and all cannot complete.
The treatment of facial neuritis is often divided into described below several.
1, Drug therapy, early treatment advocates with neurovascular dystrophy medicine and heavy dose of hormone.But excessive use hormone may bring many harmful effects to human body, even and if use hormone its can to work also be the treatment cycle needing more than two weeks.
2, physiotherapy, early stage available magnetic therapy, infrared ray.Later stage can do facial muscle motion, but early stage in disease, this facial muscle motion exercise is not only unhelpful, is harmful on the contrary, and strong pleural muscle meat can be made too active.
3, acupuncture and moxibustion treatment.Acupuncture and moxibustion treatment can bring misery to human body, and the personnel grasping acupuncture technique are limited, uneven, is difficult to extensive popularization.
4, operative therapy, for completeness facial paralysis, nerve excitability test threshold value both sides difference 3.5 ~ 4mA, facial nerve electrograph loss are greater than more than 90%, electromyogram without random electrical activity but have fibrillation, sick 3 weeks or to after 2 months still without any recovery sign, feasible facial nerve decompression.But for patients, distress level is large, and delay length for operative therapy, recovers slow.
Therefore, in sum, there is following problem in the neuritic treatment in opposite both at home and abroad at present:
1, conventional therapy is long for the course for the treatment of, generally takes more than one month time and can recover normal.
2, conventional therapy misery is many, the many miseries will standing the Comprehensive Treatments such as acupuncture, vitamin B complex, bendazol of conventional therapy.
3, conventional therapy side effect is large, and the easy soft tissue injury of acupuncture and moxibustion therapy, causes local swelling infection etc., and oral drugs are many containing hormone medicine, the immune function of infringement body.
4, conventional therapy is once failure, and using other treatment instead will add to the difficulties, and even cause irreversible symptom, the course of disease then how will be treated by operation more than 6 months.
Although also there is the Chinese patent medicine of some treatment facial neuritises, because effect is not fairly obvious, and treatment cycle is long, mouthfeel is poor etc., and reason is not easy to promote the use of.
Therefore, market needs one have no side effect, effectively can treat the medicine of facial neuritis in a short time.
Summary of the invention
For the problems referred to above, the invention provides a kind for the treatment of facial neuritis plaster and preparation method thereof with dredging collateral, reducing swelling and alleviating pain, activation downright bad nervous tissue effect.
The present invention is according to traditional Chinese medical science traditional theory, in conjunction with the long-term clinical practice of inventor on secret prescription handed down in the family from generation to generation basis, with reference to modern pharmacological research achievement, scientific allocation is carried out to former prescription, define with expelling wind and cold, heat clearing away dredging collateral, the Chinese crude drug of reducing swelling and alleviating pain is by theory of Chinese medical science prescription, its pathogen is dispelled, healthy energy is recovered, meridians are unobstructed, activate neural, thus reach therapeutic purposes, particularly it activates downright bad effects on neural system, become " new model " of infusive treatment facial neuritis sequela (intractable facial neuritis), light the hope for the treatment of facial neuritis sequela (intractable facial neuritis) patient.
Specifically, the invention provides a kind of method for the preparation of facial neuritis medicine, it is characterized in that, described method comprises the steps:
Step 1), get the Plumbum preparatium of the first scheduled volume, and processed is carried out to it;
Step 2), get the Scolopendra of the second scheduled volume, and be placed in the Oleum sesami of the 3rd scheduled volume and heated for first scheduled time;
Step 3), pull step 2 out) obtain residue in mixture, obtain medicine oil;
Step 4), under the first predetermined temperature, obtained medicine oil is decocted further;
Step 5), in described medicine oil, add step 1 gradually) process after Plumbum preparatium;
Step 6), by step 5) mixture that obtains is down to the second predetermined temperature;
Step 7), add the ceramics of the 4th scheduled volume and the azone of the 5th scheduled volume in the resulting mixture.
In the preferred implementation of one, described first scheduled volume is 80-120 part by weight; Described second scheduled volume is 4-8 part by weight; Described 3rd scheduled volume is 180-220 part by weight; Described 4th scheduled volume is 8-12 part by weight; Described 5th scheduled volume is 3-5 part by weight.
In the preferred implementation of one, described step 1) in processed is carried out to Plumbum preparatium refer to and Plumbum preparatium to be put in vessel heat drying to bronzing;
Described step 2) comprise and 20-30 minute is heated to the mixture of Scolopendra and Oleum sesami, to Scolopendra outside in dark brown;
Described step 3) be also included in described medicine residue pulled out after, continue fried 5-15 minute;
Described step 4) comprise to described medicine oil carry out further the fried oil droplet to described medicine oil after oozing in pearl; Described step 5) temperature that is included in described medicine oil is when reaching 300-330 DEG C, and while stirring, add Plumbum preparatium gradually, and when reacting the white cigarette given out and eliminating, stop heating;
Described step 6) and 7) comprise when the temperature of described medicine oil is down to 60-70 DEG C, add ceramics, and then add azone.
In the preferred implementation of one, described method also comprises:
Step 8): to described step 7) product that obtains carries out cooling condensation, and be placed in cold water and soaked for second scheduled time, obtain facial neuritis medicine.
In the preferred implementation of one, described method also comprises:
Step 9): by step 8) the facial neuritis medicine that obtains dries in the shade surface moisture, fire insulation molten is evenly coated on the substrate of reservation shape, forms the plaster being used for the treatment of facial neuritis.Substrate can adopt cloth or other gas permeable materials.
On the other hand, the invention provides a kind of medicine for the treatment of facial neuritis, it is characterized in that, described medicine comprises: the ester extract of Scolopendra or Scolopendra, ceramics, azone, Plumbum preparatium, Oleum sesami.
In the preferred implementation of one, the raw materials of described medicine comprises Scolopendra 4-8 part, ceramics 8-12 part, azone 3-5 part, Plumbum preparatium 80-120, Oleum sesami 180-220.
In the preferred implementation of one, described medicine is for utilizing described raw materials based on the method preparation in claim 1-5 described in any one.
The optimum feed stock weight proportion of medicine of the present invention is: Scolopendra 6 parts, ceramics 10 parts, azone 3 parts, 100 parts, Plumbum preparatium, Oleum sesami 200 parts.
In the preferred implementation of one, in step 3) after, the mixture also after described plaster (step 3) decocts) in add the water extract dried powder of following substances: Flos Chrysanthemi 5 parts, Radix Puerariae 8 parts, Folium Isatidis 12 parts, 4 parts, Radix Glycyrrhizae and Radix Saposhnikoviae 9 parts.In addition, the ester extract concentrated solution of following material is also added wherein: the Radix Angelicae Dahuricae 5 parts, Periostracum Cicadae 5 parts, Bombyx Batryticatus 5 parts, Rhizoma Chuanxiong 5 parts.Here mentioned ester extract concentrated solution refer to above-mentioned substance added in Oleum sesami or other oils decoct after remove the product of residue.
Clinical drug of the present invention uses result to show there is following advantage:
The present invention selects Chinese crude drug to be raw material, and each component meets pharmaceutical control law regulation.Utilize the comprehensive function treatment facial neuritis of each taste Chinese medicine, harmless to human non-toxic.The present invention applies conveniently, and patient's misery is little, time saving and energy saving.The present invention applies separately, without the need to coordinating other treatment.Short treating period, as treated (particularly acupuncture) without other, generally take about 7 days time and just can recover normal, one or two people just can fully recover 1 to 2 day time.
Conventional therapy is once failure, use this method treatment (course of disease is no more than 1 year person) instead still effective, this is the intractable facial neuritis of a kind of infusive treatment " new model ", is the hope of facial neuritis sequela (intractable facial neuritis) patient.
Product of the present invention has good therapeutic effect to facial neuritis patient, and concrete condition is as follows:
Onset patient (particularly not through acupuncture and moxibustion therapy person), only 1 to 9 day not etc. for treatment cycle, significantly lower than the cycle (general about 1 month of the treatment cycle of conventional therapy) of conventional therapy, effective percentage reaches 100%, is significantly higher than the effective percentage about 90% of conventional therapy.Sequela person that facial neuritis stays (course of disease was more than 3 months), namely nervus facialis necrosis is considered as, particularly the course of disease was more than 6 months persons, for nervus facialis irreversibility is downright bad, the present invention also reaches therapeutic purposes by activating downright bad nerve, effective percentage reaches more than 80%, and having broken the course of disease just must by operative treatment just curable final conclusion more than 6 months.Successful treatment case of the present invention comprises a course of disease more than 1 year patient, recovery from illness after product treatment of the present invention.
Accompanying drawing explanation
Fig. 1 is the preparation flow schematic diagram of medicine according to an embodiment of the invention.
Detailed description of the invention
Embodiment one
In the present embodiment, preparation adopt raw material as follows: Scolopendra 6 parts, ceramics 10 parts, azone 3 parts, 100 parts, Plumbum preparatium, Oleum sesami 200 parts, wherein, the content of every part is 10g.
Concrete pharmacy procedure is as follows:
Plumbum preparatium is put in dry in aluminum pot stir-fry to bronzing, removes moisture in Plumbum preparatium, put spare after cool.
Scolopendra is put into the aluminum pot slow fire frying 20-30 minute filling Oleum sesami, during fried material, constantly stir with Ramulus et Folium Tamaricis branch or Ramulus Mori or Rumalus sophorae, medicine is heated evenly, can decoct, to reach the active ingredient of better extracting medicine, when oil temperature reaches 200 DEG C about-250 DEG C, medicinal residues, in dark brown, during non-carbonization, are namely pulled out with strainer by Scolopendra outside, medicine oil is continued fried about ten minutes, the oxide evaporation produced to impel Oleum sesami and medicine makes the impurity in medicine oil minimize, and to improve the quality of plaster, prepares drug oil.
Continue to decoct medicine oil to when dripping into pearl (when oil temperature reaches about 320 DEG C) with warm fire, slowly drop into Plumbum preparatium, ceaselessly stir to a direction with Ramulus et Folium Tamaricis branch or Ramulus Mori or Rumalus sophorae simultaneously, when waiting white cigarette to eliminate, stop heating.
Be down to when 60-70 spends until medicine oil temperature and add ceramics, finally add penetrant azone, be ceaselessly stirred to a direction with Ramulus et Folium Tamaricis branch or Ramulus Mori or Rumalus sophorae and drip into pearl.
Plaster is poured in 4000-5000ml cold water basin, constantly stir, make it become band, repeatedly pinch after condensing and be kneaded into bulk, put into cold water and soak 5-7 days except releasing fire-toxin, and more renew water number every day, namely make the plaster for the treatment of facial neuritis.
Dry in the shade after surface moisture, fire insulation molten, spreads out in the cloth of 5 × 7cm ellipse, large size every note stand plaster 10g, small size every note 8g, circular shaped plaster diameter 2cm (2g).
Plaster is affixed on Ipsilateral face, and with pain person after ear, nebula wind scoop sticks on diameter 2cm (2g) circular shaped plaster, can not close, the sagging person in canthus with eye, and temple stick on diameter 2cm (2g) circular shaped plaster.
For showing the neuritic magical therapeutic effect in medicine opposite of the present invention, citing shows:
Model case:
Open X, man, 19 years old, December in 2013 first visit on the 23rd.Left side facial hemiparalysis 3 days, find when early morning washes one's face before 3 days that left eye can not close, and does not control, look into left volume stricture of vagina and disappear, frown, close order, the drum cheek can not, nasolabial fold is askew to the right.
The plaster lost money in a business prepared by invention totally 1 pastes (2 days) in Ipsilateral face, treatment recovery from illness.
King X, female, 43 years old, first visit on the 17th in 08 month in 2009.Left side facial hemiparalysis more than 1 year, finds when early morning washes one's face before 1 year that left eye can not close, and then arrives hospital's conventional therapy (application prednisone, vitamin B complex, methylcobalamin tablet, bendazol etc., another acupuncture and moxibustion therapy 8 months), the readme state of an illness slightly takes a turn for the better, and facial hemiparalysis is just slightly being led.Look into left volume stricture of vagina to disappear, can not close order completely, the drum cheek slightly leaks gas, nasolabial fold is askew to the right.
The plaster lost money in a business prepared by invention 23 pastes in Ipsilateral face totally, treatment recovery from illness.
Pan X, man, 32 years old, first visit on the 06th in 07 month in 2013.Right side facial hemiparalysis more than 40 days, after air-conditioned room of sleeping after drinking before 40 days, pain after ear on the right side of occurring, on the right side of when having a meal, the corners of the mouth leaks rice grain, then carry out Drug therapy (medicine name and dosage not quite clear) and acupuncture and moxibustion therapy 1 month, the state of an illness slightly takes a turn for the better, and facial hemiparalysis is just slightly being led.Look into right volume stricture of vagina to disappear, can not close order, the gas leakage of the drum cheek completely, nasolabial fold is askew left.
The plaster lost money in a business prepared by invention totally 6 pastes (20 days) in Ipsilateral face, treatment recovery from illness.
Therefore, clinical trial demonstrates, and medicine of the present invention can treat facial neuritis effectively, and its patient for various ill duration all has positive effect.
Embodiment two
In the present embodiment, adopt and preparation method similar in embodiment one, just have adjusted the proportioning of raw material.In the present embodiment, adopt raw material as follows: Scolopendra 5 parts, ceramics 12 parts, azone 5 parts, 110 parts, Plumbum preparatium, Oleum sesami 180 parts, Flos Chrysanthemi 5 parts, Radix Puerariae 8 parts, Folium Isatidis 12 parts, 4 parts, Radix Glycyrrhizae, Radix Saposhnikoviae 9 parts, the Radix Angelicae Dahuricae 5 parts, Periostracum Cicadae 5 parts, Bombyx Batryticatus 5 parts, Rhizoma Chuanxiong 5 parts.
In the present embodiment, preparation method is substantially identical with embodiment one, just after being pulled out from Oleum sesami by Scolopendra residue, add water extract dried powder or the water extracting liquid of following substances in the mixture also after decocting: Flos Chrysanthemi 5 parts, Radix Puerariae 8 parts, Folium Isatidis 12 parts, 4 parts, Radix Glycyrrhizae and Radix Saposhnikoviae 9 parts.Concrete grammar is for add in pure water by above-mentioned material, and heating decocts 1-2 hour, and then aqueous solution is carried out drying by reject residue, obtains corresponding powder or concentrated solution.
In addition, the ester extract concentrated solution of following material is also added wherein: the Radix Angelicae Dahuricae 5 parts, Periostracum Cicadae 5 parts, Bombyx Batryticatus 5 parts, Rhizoma Chuanxiong 5 parts.Here mentioned ester extract concentrated solution refers to above-mentioned substance to add in Oleum sesami or other Esters and decocts and remove the product after residue.
Adopt the mode in embodiment two, made plaster has effect of significantly treatment facial neuritis, and this formula uses rear patient Geng Yi to absorb, and acceptance is better.
In the preferred implementation of another kind, also add the water extract of Herba Lycopodii 8-11 part in the mixture.
In addition, it should be noted that, although define the quality of each raw material in claims, it should be appreciated by those skilled in the art that the composition of each raw material equal proportion can increase or reduce.Also it should be noted that, raw material of the present invention is conventional commercially available Chinese crude drug, is not described in detail here.
It should be noted that; although with specific embodiments and the drawings describes in detail invention has been above; but; description is above only schematically illustrate; so that those skilled in the art's the understanding of the present invention, the restriction of detail not to invention protection domain of parts shown in figure.Those skilled in the art also should be appreciated that, above-described embodiment is also only the explanation to exemplary implementation of the present invention, not limiting the scope of the invention.
Claims (10)
1. for the preparation of a method for facial neuritis medicine, it is characterized in that, described method comprises the steps:
Step 1), get the Plumbum preparatium of the first scheduled volume, and processed is carried out to it;
Step 2), get the Scolopendra of the second scheduled volume, and be placed on homogeneous heating first scheduled time in the Oleum sesami of the 3rd scheduled volume;
Step 3), when Oleum sesami temperature reaches the first predetermined temperature, pull step 2 out) obtain residue in mixture, obtain medicine oil;
Step 4), lasting second scheduled time is decocted further to obtained medicine oil;
Step 5), in described medicine oil, add step 1 gradually) process after Plumbum preparatium;
Step 6), by step 5) mixture that obtains is down to the second predetermined temperature;
Step 7), add the ceramics of the 4th scheduled volume and the azone of the 5th scheduled volume in the resulting mixture.
2. the method for the preparation of facial neuritis medicine according to claim 1, is characterized in that, described first scheduled volume is 80-120 part by weight; Described second scheduled volume is 4-8 part by weight; Described 3rd scheduled volume is 180-220 part by weight; Described 4th scheduled volume is 8-12 part by weight; Described 5th scheduled volume is 3-5 part by weight.
3. the method for the preparation of facial neuritis medicine according to claim 1 and 2, is characterized in that, described first scheduled time is 20-30 minute; Described second scheduled time is 8-10 minute; Described first predetermined temperature is 200-250 DEG C, and described second predetermined temperature is 60-70 DEG C.
4. the method for the preparation of facial neuritis medicine according to claim 1, is characterized in that,
Described step 1) in processed is carried out to Plumbum preparatium refer to and Plumbum preparatium to be put in vessel heat drying to bronzing;
Described step 2) comprise and 20-30 minute is heated to the mixture of Scolopendra and Oleum sesami, to Scolopendra outside in dark brown;
Described step 3) be included in described medicine residue pulled out after, continue fried 5-15 minute;
Described step 4) comprise to described medicine oil carry out further the fried oil droplet to described medicine oil after oozing in pearl;
Described step 5) temperature that is included in described medicine oil is when reaching 300-330 DEG C, and while stirring, add Plumbum preparatium gradually, and when reacting the white cigarette given out and eliminating, stop heating;
Described step 6) and 7) comprise when the temperature of described medicine oil is down to 60-70 DEG C, add ceramics, and then add azone.
5. the method for the preparation of facial neuritis medicine according to claim 4, is characterized in that, described method also comprises:
Step 8), to described step 7) product that obtains carries out cooling condensation, and is placed in cold water and soaks for second scheduled time, obtains facial neuritis medicine.
6. the method for the preparation of facial neuritis medicine according to claim 5, is characterized in that, described method also comprises:
Step 9), by step 8) the facial neuritis medicine that obtains dries in the shade surface moisture, fire insulation molten is evenly coated on the substrate of reservation shape, forms the plaster being used for the treatment of facial neuritis.
7. treat a medicine for facial neuritis, it is characterized in that, described medicine is made up of the ester extract of Scolopendra or Scolopendra, ceramics, azone, Plumbum preparatium, Oleum sesami.
8. the medicine for the treatment of facial neuritis according to claim 7, it is characterized in that, the raw materials of described medicine comprises Scolopendra 4-8 part, ceramics 8-12 part, azone 3-5 part, Plumbum preparatium 80-120, Oleum sesami 180-220, and described medicine is the product of above-mentioned raw materials after Hybrid Heating.
9. the medicine for the treatment of facial neuritis according to claim 7, is characterized in that, the raw materials of described medicine comprises: Scolopendra 6 parts, ceramics 10 parts, azone 3 parts, 100 parts, Plumbum preparatium, Oleum sesami 200 parts.
10. the medicine for the treatment of facial neuritis according to claim 9, is characterized in that, described medicine is for utilizing described raw materials based on the method preparation in claim 1-6 described in any one.
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| CN201510194843.4A CN104771423B (en) | 2015-04-22 | 2015-04-22 | A kind of method and relative medicine for being used to prepare facial neuritis medicine |
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| CN201510194843.4A CN104771423B (en) | 2015-04-22 | 2015-04-22 | A kind of method and relative medicine for being used to prepare facial neuritis medicine |
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| CN105663979A (en) * | 2015-12-31 | 2016-06-15 | 泰山医学院 | External-apply plaster for treating facial paralysis caused by head injury, and preparation method thereof |
| CN105770333A (en) * | 2016-03-14 | 2016-07-20 | 杨朋 | Medicinal composition for treating facial neuritis |
| CN106039006A (en) * | 2016-06-29 | 2016-10-26 | 杨晨阳 | Traditional Chinese medicine composition for treating facial neuritis and preparation method of traditional Chinese medicine composition |
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| CN1393235A (en) * | 2001-06-26 | 2003-01-29 | 利津县第二人民医院 | Plaster for treating facial neuritis and its preparing process |
| CN101912572A (en) * | 2010-07-30 | 2010-12-15 | 崔宝海 | Multi-effect external plaster |
| CN102423364A (en) * | 2011-11-29 | 2012-04-25 | 丁荣松 | Straightening plaster for treating facial paralysis and preparation method thereof |
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| CN1393235A (en) * | 2001-06-26 | 2003-01-29 | 利津县第二人民医院 | Plaster for treating facial neuritis and its preparing process |
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| CN105663979A (en) * | 2015-12-31 | 2016-06-15 | 泰山医学院 | External-apply plaster for treating facial paralysis caused by head injury, and preparation method thereof |
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| CN106039006A (en) * | 2016-06-29 | 2016-10-26 | 杨晨阳 | Traditional Chinese medicine composition for treating facial neuritis and preparation method of traditional Chinese medicine composition |
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| CN104771423B (en) | 2018-05-04 |
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