CN104768533A - 治疗性制剂和治疗方法 - Google Patents
治疗性制剂和治疗方法 Download PDFInfo
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- CN104768533A CN104768533A CN201380042670.3A CN201380042670A CN104768533A CN 104768533 A CN104768533 A CN 104768533A CN 201380042670 A CN201380042670 A CN 201380042670A CN 104768533 A CN104768533 A CN 104768533A
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229940041022 streptomycins Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 208000037905 systemic hypertension Diseases 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000000015 thermotherapy Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 239000012749 thinning agent Substances 0.000 description 1
- 230000009092 tissue dysfunction Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 238000002691 topical anesthesia Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000003606 umbilical vein Anatomy 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 108010080213 vascular factor Proteins 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261658304P | 2012-06-11 | 2012-06-11 | |
| US61/658304 | 2012-06-11 | ||
| PCT/US2013/044617 WO2013188217A1 (en) | 2012-06-11 | 2013-06-06 | Therapeutic formulation and methods of treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104768533A true CN104768533A (zh) | 2015-07-08 |
Family
ID=49715792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380042670.3A Pending CN104768533A (zh) | 2012-06-11 | 2013-06-06 | 治疗性制剂和治疗方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9254287B2 (https=) |
| JP (1) | JP2015519398A (https=) |
| KR (1) | KR20150032552A (https=) |
| CN (1) | CN104768533A (https=) |
| AU (1) | AU2013274582A1 (https=) |
| HK (1) | HK1212225A1 (https=) |
| SG (1) | SG11201408230VA (https=) |
| TW (1) | TW201410245A (https=) |
| WO (1) | WO2013188217A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112007031A (zh) * | 2019-05-30 | 2020-12-01 | 杏国新药股份有限公司 | 眼用制剂 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015164419A1 (en) * | 2014-04-22 | 2015-10-29 | Acucela Inc. | Pupillometric assessment of retinal pharmacodynamics and responses therefrom |
| KR20170115514A (ko) | 2014-12-30 | 2017-10-17 | 셀 큐어 뉴로사이언시스 리미티드 | Rpe 세포 집단 및 이를 생성하는 방법 |
| WO2019079515A1 (en) * | 2017-10-17 | 2019-04-25 | Apeliotus Technologies, Inc. | FUNCTIONAL BIOMARKERS FOR STATIN-BASED TREATMENT IN AGE-RELATED MACULAR DEGENERATION (AMD) |
| BR112020013238A2 (pt) | 2017-12-29 | 2020-12-01 | Cell Cure Neurosciences Ltd. | composição e método para formular células do epitélio pigmentar da retina bem como uso da dita composição para tratar uma condição retiniana |
| US12109211B2 (en) | 2021-12-29 | 2024-10-08 | Endo Operations Limited | Hydralazine compositions and methods |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5500230A (en) * | 1987-01-23 | 1996-03-19 | The General Hospital Corporation | Method for treatment of glaucoma with nitrogen containing guanylate cyclase activators |
| CN1140988A (zh) * | 1994-02-18 | 1997-01-22 | 希巴-盖古股份公司 | 液体眼科缓释投药系统 |
| US20090012057A1 (en) * | 2005-02-28 | 2009-01-08 | Nitromed, Inc. | Cardiovascular Compounds Comprising Nitric Oxide Enhancing Groups, Compositions and Methods of Use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4055645A (en) | 1976-02-13 | 1977-10-25 | Merck & Co., Inc. | Novel anti-hypertensive compositions |
| US4865599A (en) | 1986-08-18 | 1989-09-12 | Houston Biotechnology, Inc. | Ophthalmic compositions for treating nerve degeneration |
| FI873429L (fi) | 1986-08-18 | 1988-02-19 | Houston Biotechnology | Oftalmologiska kompositioner foer behandling av nervdegenerationer. |
| ATE191145T1 (de) * | 1987-01-23 | 2000-04-15 | Gen Hospital Corp | Hydralazin zur topischen behandlung von glaukom |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5252607A (en) | 1992-01-24 | 1993-10-12 | Texas A&M University System | Treatment of low pressure glaucoma and ischemic retinal degeneration |
| US5459133A (en) | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| TW264385B (https=) * | 1993-05-14 | 1995-12-01 | Taiho Pharmaceutical Co Ltd | |
| US5596011A (en) | 1995-04-06 | 1997-01-21 | Repine; Karen M. | Method for the treatment of macular degeneration |
| EP0911027A4 (en) | 1996-04-26 | 2000-11-29 | Fujisawa Pharmaceutical Co | THE DIHYDROPYRIDINE CONTAINS TO IMPROVE THE CIRCULATION OF THE EYE-SURROUNDING TISSUE |
| AU4582797A (en) | 1996-09-13 | 1998-04-02 | Regents Of The University Of California, The | Methods for treatment of retinal diseases |
| CA2270119A1 (en) | 1996-10-28 | 1998-05-07 | Senju Pharmaceutical Co., Ltd. | Drugs for ameliorating ocular circulatory disorders |
| AU741525B2 (en) | 1998-03-06 | 2001-12-06 | Board Of Regents, The University Of Texas System | Composition and method for treating macular disorders |
| US6028099A (en) | 1998-03-13 | 2000-02-22 | John Hopkins University, School Of Medicine | Use of an inhibitor of the protein tyrosine kinase pathway in the treatment of choroidal neovascularization |
| EP1161686A2 (en) | 1999-03-05 | 2001-12-12 | University Of Iowa Research Foundation | Diagnostics and therapeutics for drusen associated ocular disorders |
| IL137429A0 (en) | 1999-07-28 | 2001-07-24 | Pfizer Prod Inc | Methods and compsitions for treating diseases and conditions of the eye |
| AU779991B2 (en) | 1999-08-10 | 2005-02-24 | Board Of Regents, The University Of Texas System | Method for increasing optic nerve, choroidal and retinal blood flow to facilitate the preservation of sight |
| US6692759B1 (en) | 2000-06-28 | 2004-02-17 | The Regents Of The University Of California | Methods for preparing and using implantable substance delivery devices |
| US20030171375A1 (en) | 2002-02-13 | 2003-09-11 | Brazzell Romulus Kimbro | Method for treating ocular neovascular diseases |
| JP4599292B2 (ja) | 2002-10-30 | 2010-12-15 | エジソン ファーマシューティカルズ， インコーポレイテッド | 物理的−化学的特性に基づく治療用化合物の同定 |
| JP2004250347A (ja) | 2003-02-18 | 2004-09-09 | Ajinomoto Co Inc | 網膜虚血に基づく疾患の治療および／又は予防剤 |
| US20040214215A1 (en) | 2003-03-07 | 2004-10-28 | Yu Ruey J. | Bioavailability and improved delivery of alkaline pharmaceutical drugs |
| US20050059744A1 (en) | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
| EP1814535A4 (en) | 2004-11-08 | 2008-06-04 | Nitromed Inc | NITROSED AND NITROSYLATED COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING EYE DISEASES |
| US8088773B2 (en) | 2005-05-12 | 2012-01-03 | The Texas A&M University System | Therapeutic compositions and methods |
-
2013
- 2013-06-06 KR KR20157000568A patent/KR20150032552A/ko not_active Withdrawn
- 2013-06-06 SG SG11201408230VA patent/SG11201408230VA/en unknown
- 2013-06-06 JP JP2015517316A patent/JP2015519398A/ja not_active Ceased
- 2013-06-06 AU AU2013274582A patent/AU2013274582A1/en not_active Abandoned
- 2013-06-06 WO PCT/US2013/044617 patent/WO2013188217A1/en not_active Ceased
- 2013-06-06 CN CN201380042670.3A patent/CN104768533A/zh active Pending
- 2013-06-06 HK HK16100185.7A patent/HK1212225A1/xx unknown
- 2013-06-06 US US13/912,149 patent/US9254287B2/en not_active Expired - Fee Related
- 2013-06-07 TW TW102120341A patent/TW201410245A/zh unknown
-
2016
- 2016-02-08 US US15/018,620 patent/US9694010B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5500230A (en) * | 1987-01-23 | 1996-03-19 | The General Hospital Corporation | Method for treatment of glaucoma with nitrogen containing guanylate cyclase activators |
| CN1140988A (zh) * | 1994-02-18 | 1997-01-22 | 希巴-盖古股份公司 | 液体眼科缓释投药系统 |
| US20090012057A1 (en) * | 2005-02-28 | 2009-01-08 | Nitromed, Inc. | Cardiovascular Compounds Comprising Nitric Oxide Enhancing Groups, Compositions and Methods of Use |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112007031A (zh) * | 2019-05-30 | 2020-12-01 | 杏国新药股份有限公司 | 眼用制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130331393A1 (en) | 2013-12-12 |
| JP2015519398A (ja) | 2015-07-09 |
| US20160151368A1 (en) | 2016-06-02 |
| AU2013274582A1 (en) | 2015-01-22 |
| TW201410245A (zh) | 2014-03-16 |
| SG11201408230VA (en) | 2015-01-29 |
| WO2013188217A1 (en) | 2013-12-19 |
| KR20150032552A (ko) | 2015-03-26 |
| US9694010B2 (en) | 2017-07-04 |
| US9254287B2 (en) | 2016-02-09 |
| HK1212225A1 (en) | 2016-06-10 |
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