CN104764778A - Novel intelligent blood glucose monitor - Google Patents
Novel intelligent blood glucose monitor Download PDFInfo
- Publication number
- CN104764778A CN104764778A CN201510148089.0A CN201510148089A CN104764778A CN 104764778 A CN104764778 A CN 104764778A CN 201510148089 A CN201510148089 A CN 201510148089A CN 104764778 A CN104764778 A CN 104764778A
- Authority
- CN
- China
- Prior art keywords
- circuit
- chip
- blood sugar
- blood glucose
- novel intelligent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a novel intelligent blood glucose monitor which is characterized by comprising a biosensing electrode and a signal processing circuit connected with the output end of the biosensing electrode, wherein the output end of the signal processing circuit is connected with a temperature compensation circuit and a switching circuit; the output end of the temperature compensation circuit is connected with the switching circuit; the switching circuit is sequentially connected with an A/D conversion module, a single-chip control system and a liquid crystal display circuit; and the single-chip control system is connected with an intelligent chip. The blood glucose concentration measured by the intelligent blood glucose monitor disclosed by the invention has obvious correlation with the measurement result of a high-precision glucose meter, and the intelligent blood glucose monitor has the advantages of easiness and convenience in operation, short measurement time, accurate and reliable result, high intelligent degree, low power consumption and the like.
Description
Technical field
The present invention relates to medical endocrine monitoring technical field, especially relate to a kind of novel intelligent blood sugar monitoring instrument.
Background technology
diabetes are a kind of common metabolism endocrine system diseases, and being owing to lacking in human body caused by insulin or its receptor abnormality, take hyperglycaemia as principal character, are the worldwide pandemic of one.Its morbidity is in remarkable ascendant trend in recent years, and the current whole world about has the adult of 10% to suffer from this disease.In China, diabetic about has 4,000 ten thousand people, and current therapeutic modality mainly regulates and controls the glucose metabolism in patient body, and the important evidence of clinical treatment administration is the blood-glucose content of patient.Therefore, be very important by the control that self-monitoring of blood glucose instrument is followed the trail of, assess diabetes.Particularly self-monitoring of blood glucose instrument can facilitate, promptly detect result in hospital even family, and existing market blood glucose meter product can only provide blood glucose value, and patient will adjust therapeutic scheme accordingly, diet control also exists certain difficulty.In addition, measuring accuracy, test specification all Shortcomings.
Summary of the invention
Technical matters to be solved by this invention is for above-mentioned deficiency of the prior art, a kind of novel intelligent blood sugar monitoring instrument is provided, the blood sugar concentration result that Intelligent blood sugar monitor of the present invention records and high precision blood glucose meter measurement result have significant correlativity, and have easy and simple to handle, Measuring Time is short, result more accurately and reliably, the advantages such as intelligence degree is high, low-power consumption.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of novel intelligent blood sugar monitoring instrument, it is characterized in that: the signal processing circuit comprising bio-sensing electrode and be connected with its output terminal, described signal processing circuit output terminal is connected with temperature-compensation circuit and on-off circuit, described temperature-compensation circuit output terminal is also connected with on-off circuit, described on-off circuit is connected successively with A/D modular converter, single-chip computer control system, liquid crystal display circuit, and described single-chip computer control system is also connected with intelligent chip.
Above-mentioned a kind of novel intelligent blood sugar monitoring instrument, is characterized in that: described bio-sensing electrode is glucose oxidase (GOD) in electrode surface solidification.
Above-mentioned a kind of novel intelligent blood sugar monitoring instrument, is characterized in that: described temperature-compensation circuit adopts the unibus micro temperature sensor DS18B20 of DALLAS company to realize.
Above-mentioned a kind of novel intelligent blood sugar monitoring instrument, is characterized in that: described single-chip computer control system is MSP430 single-chip microcomputer.
Above-mentioned a kind of novel intelligent blood sugar monitoring instrument, is characterized in that: described A/D modular converter is high-precision a/d converter AD7864 chip.
The present invention compared with prior art has the following advantages:
The blood sugar concentration result that Intelligent blood sugar monitor of the present invention records and high precision blood glucose meter measurement result have significant correlativity, and have easy and simple to handle, and Measuring Time is short, result more accurately and reliably, the advantages such as intelligence degree is high, low-power consumption.
Below by drawings and Examples, technical scheme of the present invention is described in further detail.
Accompanying drawing explanation
Fig. 1 is system monitor theory diagram of the present invention;
Fig. 2 is signal conditioning circuit schematic diagram of the present invention;
Fig. 3 is blood sugar test data fitting curve map of the present invention.
Embodiment
As shown in Figure 1, a kind of novel intelligent blood sugar monitoring instrument, it is characterized in that: the signal processing circuit 2 comprising bio-sensing electrode 1 and be connected with its output terminal, described signal processing circuit 2 output terminal is connected with temperature-compensation circuit 3 and on-off circuit 4, described temperature-compensation circuit 3 output terminal is also connected with on-off circuit 4, described on-off circuit 4 is connected successively with A/D modular converter 7, single-chip computer control system 6, liquid crystal display circuit 5, and described single-chip computer control system 6 is also connected with intelligent chip 8.
In the present embodiment, described bio-sensing electrode 1 is glucose oxidase (GOD) in electrode surface solidification.When after blood instillation blood sugar test electrode, there occurs redox reaction, ferrous ion in course of reaction in transmission medium loses electronics, there occurs oxidation reaction, glucose oxidase glucose generates H2O2 and gluconic acid, and H2O2, by oxidation of divalent iron ion, there occurs electron exchange phenomenon in oxidation-reduction process, under the effect of certain voltage, define oxidation current.Be similar to linear by detection curent change and concentration of glucose, thus reach the object detecting blood sugar concentration.
In the present embodiment, described temperature-compensation circuit 3 adopts the unibus micro temperature sensor DS18B20 of DALLAS company to realize.The change of environment temperature causes the change of detection system zero point drift and sensitivity and causes measuring error.For eliminating the impact of environment temperature, in system, temperature-compensation circuit adopts the unibus micro temperature sensor DS18B20 of DALLAS company to realize, and its temperature-measuring range is-55 ~+125 DEG C, and Measurement Resolution is 0.0625 DEG C, and temperature measurement accuracy is ± 0.5 DEG C.Temperature signal inputs single-chip microcomputer through multi-way switch, and CPU carries out the auto modification of test result error according to the temperature characterisitic of blood sugar test electrode.
In the present embodiment, described single-chip computer control system 6 is MSP430 single-chip microcomputer, and instrument can according to the change of voltage in test process, and auto-breaking after taking-up test paper, saves energy consumption effectively.It has the following advantages:
(1) processing power is strong
MSP430 series monolithic is the single-chip microcomputer of 16, have employed reduced instruction set computer (RISC) structure, there is abundant addressing mode (7 kinds of source operand addressing, 4 kinds of destination operand addressing), 27 succinct core instructions and a large amount of dummy instructions; In a large amount of registers and sheet, data-carrier store all can participate in multiple computing; To table look-up efficiently in addition processing instruction.These features ensure that and can develop high efficiency source program.
(2) fast operation
MSP430 series monolithic under the driving of 25MHz crystal, can realize the instruction cycle of 40ns.The data width of 16, the instruction cycle of 40ns and multi-functional hardware multiplier (can realize multiply-add operation) match, and can realize some algorithm (as FFT etc.) of digital signal processing.
(3) super low-power consumption
Why MSP430 single-chip microcomputer has ultralow power consumption, is because it has its distinctive feature in the supply voltage reducing chip and flexible and controlled operation clock.
First, what the supply voltage of MSP430 series monolithic adopted is 1.8-3.6V voltage.When it thus can be made to run under the Clock of 1MHz, the minimum meeting of electric current of chip is at 165 μ about A, and the lowest power consumption under RAM Holdover mode only has 0.1 μ A.
Secondly, unique Clock System Design.The clock system that two different is had: fundamental clock system, FLL (FLL and FLL+) clock system and DCO digital oscillator clock system in MSP430 series.Only can use a crystal oscillator (32.768kHz) DT-26 OR DT-38 [4], also can use two crystal oscillators.The clock needed for CPU and each function is produced by system clock system.And these clocks under the control of instruction, can open and close, thus realize the control to overall power consumption.
Because the functional module of opening during system cloud gray model is different, namely adopt different mode of operations, the power consumption of chip has significant difference.Total a kind of activity pattern (AM) and five kinds of low-power consumption modes (LPM0-LPM4) in systems in which.Under real-time clock pattern, 2.5 μ A can be reached, under RAM Holdover mode, minimumly reach 0.1 μ A.
In the present embodiment, described A/D modular converter 7 is high-precision a/d converter AD7864 chip.AD7864 is 12 analog to digital converters that a high-speed low-power-consumption four-way synchronized sampling list 5 V powers.It comprises 1.65 μ s successive approximation analog to digital C, four sample/hold amplifiers, 2.5 V Voltage References, clock oscillator, signal conditioning circuit and a high speed parallel interface, it can the input signal of synchronized sampling four paths to keep the relative status information of four tunnel analog inputs.AD7864 acceptable input reference signal is: AD7864-1 type is ± 10 V, ± 5 V; AD7864-2 type is 0 ~ 2.5 V, 0 ~ 5 V; AD7864-3 type is ± 2.5 V.The overvoltage protection of analog input can allow input voltage to reach ± 20 V respectively ,+20 V/-1 V ,+20/-5 V and on device do not produce infringement or impact.Channel selecting can be selected by software or hardware.Low in energy consumptionly reach 90 mW, 20 μ W under battery saving mode, can be reached.When AD7864 four-way works simultaneously, maximum sampling rate can up to 130 kHz.AD7864 has sheet internal clock, read-write allows logic, multiple channel selecting mode and inner accurate 2.5 V reference voltages, and this makes the interface of itself and high speed processor become very simple.
As shown in Figure 1, the micro-electric current that produces after enzyme electrode of bleeding is less, can only reach a microampere magnitude, is not easy to measure and analyze, so first convert it to voltage signal, and then carries out voltage amplification.Because the system noise produced from power supply and various factors undesired signal affects measuring accuracy, thus should design filtering circuit and remove undesired signal, make test more accurate.In system, signal conditioning circuit as shown in Figure 2.After instrument start powers on, Single-chip Controlling multi-way switch S1 closes, and prime amplifier is input as R1 and R2 partial pressure value, is set as 0.4V.According to follower and ideal operational amplifier characteristic, now rear class exports constant is also 0.4V, through A/D conversion input single-chip microcomputer, controls display screen display " please insert test paper ".When system inserts blood sugar test paper, S2 closes, and R4 introduces circuit.Rear class amplifier forms in-phase amplifier, and adjustment R4 makes circuit output valve be 0.6V.Then again through A/D conversion input single-chip microcomputer, and control display screen display " please bleed ".The current signal produced after bleeding is from " Input " input, and output voltage signal suddenly change and inputs single-chip microcomputer after converting, and reacts and terminates calculate blood glucose value according to change in voltage and show afterwards.
In order to improve the practicality of instrument further, facilitating patient as much as possible, introducing Artificial Intelligence in instrument, patient can obtain individual state of an illness information and show simple treating method and points for attention while detection own blood glucose concentration.This function is mainly by calling realizing with the information in the intelligent chip in Diabetes Mellitus Knowledge storehouse of have cured.The knowledge base of solidifying in this chip is that the treatment guidelines published according to the World Health Organization (WHO), IDF and the approval of diabetes mellitus in China association is made, and guide has authority in diabetic analysis.Patient after recording blood glucose value, can select " reasoning " function at operation interface.
For verifying the true and reliable property of this blood-sugar detecting instrument determination data, detect by the test sample book that Intelligent blood sugar instrument and Italy large-scale Biochemical Analyzer are different to blood sugar concentration respectively.Testing result shows: the two has good consistance, and hyperglycaemia value place error ratio hypoglycemia and euglycemia place greatly, need to demarcate further and calibration.Carry out regretional analysis to test data, fitting result as shown in Figure 3.Regression equation is y=0.9851x-0.0806, in formula: regression coefficient b=0.9851, intercept a=-0.0806, coefficient R=0.9962, standard deviation SD=0.2378.
The above; it is only preferred embodiment of the present invention; not the present invention is imposed any restrictions, every above embodiment is done according to the technology of the present invention essence any simple modification, change and equivalent structure change, all still belong in the protection domain of technical solution of the present invention.
Claims (5)
1. a novel intelligent blood sugar monitoring instrument, it is characterized in that: the signal processing circuit (2) comprising bio-sensing electrode (1) and be connected with its output terminal, described signal processing circuit (2) output terminal is connected with temperature-compensation circuit (3) and on-off circuit (4), described temperature-compensation circuit (3) output terminal is also connected with on-off circuit (4), described on-off circuit (4) is connected successively with A/D modular converter (7), single-chip computer control system (6), liquid crystal display circuit (5), and described single-chip computer control system (6) is also connected with intelligent chip (8).
2. according to a kind of novel intelligent blood sugar monitoring instrument according to claim 1, it is characterized in that: described bio-sensing electrode (1) is glucose oxidase (GOD) in electrode surface solidification.
3. according to a kind of novel intelligent blood sugar monitoring instrument according to claim 1, it is characterized in that: described temperature-compensation circuit (3) adopts the unibus micro temperature sensor DS18B20 of DALLAS company to realize.
4. according to a kind of novel intelligent blood sugar monitoring instrument according to claim 1, it is characterized in that: described single-chip computer control system (6) is MSP430 single-chip microcomputer.
5. according to a kind of novel intelligent blood sugar monitoring instrument according to claim 1, it is characterized in that: described A/D modular converter (7) is high-precision a/d converter AD7864 chip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510148089.0A CN104764778A (en) | 2015-03-31 | 2015-03-31 | Novel intelligent blood glucose monitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510148089.0A CN104764778A (en) | 2015-03-31 | 2015-03-31 | Novel intelligent blood glucose monitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104764778A true CN104764778A (en) | 2015-07-08 |
Family
ID=53646742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510148089.0A Pending CN104764778A (en) | 2015-03-31 | 2015-03-31 | Novel intelligent blood glucose monitor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104764778A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105353005A (en) * | 2015-09-29 | 2016-02-24 | 扬中市恒海电子科技有限公司 | blood glucose meter |
| CN105466979A (en) * | 2015-11-23 | 2016-04-06 | 北京农业信息技术研究中心 | On-line detection device of small organic molecules of plants and method thereof |
| CN109655516A (en) * | 2018-12-31 | 2019-04-19 | 深圳硅基传感科技有限公司 | The test platform of electrochemical parameter |
| WO2019147582A1 (en) * | 2018-01-23 | 2019-08-01 | Dexcom, Inc. | Systems, devices, and methods to compensate for temperature effects on sensors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204086205U (en) * | 2014-09-05 | 2015-01-07 | 牛兆霞 | A kind of novel intelligent blood sugar monitoring instrument |
-
2015
- 2015-03-31 CN CN201510148089.0A patent/CN104764778A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204086205U (en) * | 2014-09-05 | 2015-01-07 | 牛兆霞 | A kind of novel intelligent blood sugar monitoring instrument |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105353005A (en) * | 2015-09-29 | 2016-02-24 | 扬中市恒海电子科技有限公司 | blood glucose meter |
| CN105466979A (en) * | 2015-11-23 | 2016-04-06 | 北京农业信息技术研究中心 | On-line detection device of small organic molecules of plants and method thereof |
| CN105466979B (en) * | 2015-11-23 | 2018-09-11 | 北京农业信息技术研究中心 | Plant organic molecule on-line measuring device and method |
| WO2019147582A1 (en) * | 2018-01-23 | 2019-08-01 | Dexcom, Inc. | Systems, devices, and methods to compensate for temperature effects on sensors |
| US11484233B2 (en) | 2018-01-23 | 2022-11-01 | Dexcom, Inc. | Systems, devices, and methods to compensate for temperature effects on sensors |
| US11484232B2 (en) | 2018-01-23 | 2022-11-01 | Dexcom, Inc. | Systems, devices, and methods to compensate for temperature effects on sensors |
| US11559230B2 (en) | 2018-01-23 | 2023-01-24 | Dexcom, Inc. | Systems, devices, and methods to compensate for temperature effects on sensors |
| CN109655516A (en) * | 2018-12-31 | 2019-04-19 | 深圳硅基传感科技有限公司 | The test platform of electrochemical parameter |
| CN109655516B (en) * | 2018-12-31 | 2020-04-10 | 深圳硅基传感科技有限公司 | Electrochemical parameter testing platform |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Guo et al. | Clinical identification of diabetic ketosis/diabetic ketoacidosis acid by electrochemical dual channel test strip with medical smartphone | |
| CN202204797U (en) | Blood sugar detection instrument | |
| CN104764778A (en) | Novel intelligent blood glucose monitor | |
| TWI591333B (en) | System and method for determining hematocrit insensitive glucose concentration | |
| CN102854230B (en) | Biological detector | |
| CN204086205U (en) | A kind of novel intelligent blood sugar monitoring instrument | |
| CN104684473B (en) | System and method for determining the concentration of glucose insensitive to hematocrit | |
| CN104990913A (en) | Gold nanoparticle growth based method for detection of glucose | |
| CN104983430B (en) | The blood-sugar detecting instrument of non-intrusion type | |
| CN104983427B (en) | The method of blood sugar for human body value detection | |
| CN204562174U (en) | A kind of non-invasive blood-sugar detecting instrument | |
| CN103525695B (en) | Portable kidney function detecting system | |
| CN203195700U (en) | Fast blood uric acid measuring instrument | |
| CN107898468A (en) | A kind of new blood sugar measuring system based on smart mobile phone | |
| CN105486731B (en) | Noninvasive dynamics monitoring probe based on Terahertz enhancing | |
| CN201788165U (en) | Portable intelligent blood glucose meter | |
| CN114002300B (en) | Circuit detection system based on liquid gate type field effect transistor biosensor | |
| CN106855576A (en) | A kind of portable glucose meter | |
| CN204744187U (en) | Blood sugar tester of no wound formula | |
| CN202404063U (en) | Glucometer with wireless communication function | |
| Li et al. | Development of the portable blood glucose meter for self-monitoring of blood glucose | |
| CN202393735U (en) | Novel glucose meter | |
| CN204971312U (en) | Non -invasive's blood sugar detector | |
| CN202471703U (en) | Blood glucose meter with solar panel | |
| CN202676662U (en) | Handheld blood glucose monitor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150708 |