Disclosure of Invention
The present disclosure has been made in view of the above-mentioned state of the art, and an object thereof is to provide a platform for testing electrochemical parameters, which can improve the efficiency of testing electrochemical parameters.
To this end, a first aspect of the present disclosure provides a platform for testing electrochemical parameters, comprising: a plurality of samples to be tested, each sample to be tested having a physical address (MAC address) with a predetermined number of bits, and each sample to be tested having a sensing unit for detecting an electrochemical parameter of a reaction solution during a test and a memory for recording the electrochemical parameter read by the sensing unit; a carrier having a plurality of receiving portions for receiving reaction solutions, and having a holder for placing a plurality of samples to be tested so that sensing portions of the samples to be tested are in contact with the reaction solutions of the receiving portions; and a determination device that is connected to the plurality of samples to be tested and assigns, to each of the samples to be tested, an equipment number whose number of bits is smaller than a prescribed number of bits of a physical address according to the physical address of the sample to be tested, wherein, in the test process, the sample to be tested sends a transmission data packet including the equipment number and an electrochemical parameter to the determination device, and the determination device determines consistency of the electrochemical parameter obtained by each of the samples to be tested based on the transmission data packet.
In the disclosure, the carrying device has a containing part for containing a reaction solution and a support for placing a plurality of samples to be detected, the sensing parts of the plurality of samples to be detected detect electrochemical parameters of the reaction solution, the samples to be detected have a physical address with a specified number of bits and a memory for recording the electrochemical parameters, the judging device is connected with the plurality of samples to be detected, and each sample to be detected is assigned with an equipment number with the number of bits smaller than the specified number of bits of the physical address according to the physical address of the sample to be detected. In the test process, the sample to be tested sends a transmission data packet containing the equipment number and the electrochemical parameters to the judgment device, and the judgment device judges the consistency of the electrochemical parameters obtained by each sample to be tested based on the transmission data packet. Under the condition, the electrochemical parameters obtained by the corresponding samples to be tested can be obtained according to the equipment numbers, so that the consistency of the multiple samples to be tested can be rapidly judged, and the test efficiency of batch tests can be improved.
In the test platform according to the first aspect of the present disclosure, optionally, the sample to be tested includes a clock unit for timing, and the clock units of the respective samples to be tested are synchronized with each other. Therefore, synchronous collection of electrochemical parameters of a plurality of samples to be detected can be ensured.
In the test platform according to the first aspect of the present disclosure, optionally, the determining device includes a timing module for synchronizing the clock sections. Therefore, the clock parts of the samples to be tested can be ensured to be synchronous with each other through the timing module.
In the test platform according to the first aspect of the present disclosure, optionally, the timing module synchronizes each sample to be tested every predetermined time period. This can further ensure that the clock sections of the plurality of samples to be measured are synchronized with each other.
In the test platform according to the first aspect of the present disclosure, optionally, the synchronization method of the timing module includes: selecting one sample to be detected as a standard sample; time resetting the clock portion of the standard sample; and carrying out time synchronization on each sample to be detected based on the time of the standard sample. Therefore, the time synchronization of each sample to be detected and the standard sample can be ensured.
In the test platform according to the first aspect of the present disclosure, optionally, in the time synchronization of each sample to be tested, a target time of the clock unit of the standard sample is obtained, and the time of each sample to be tested is synchronized to the target time. Therefore, the time of each sample to be detected can be further ensured to be synchronous with the target time of the standard sample.
In the test platform according to the first aspect of the present disclosure, optionally, the transmission data packet includes a check code, and the determination device further includes a data check module, where the data check module checks the data of the electrochemical parameter in the transmission data packet based on the check code. Therefore, the correctness of the transmitted data packet can be ensured.
In the test platform according to the first aspect of the present disclosure, optionally, the data check module checks in a manner selected from at least one of parity check, cyclic redundancy check, longitudinal redundancy check, gray code check, sum check, and xor check. Therefore, the correctness of the transmitted data packet can be further ensured.
In the test platform according to the first aspect of the present disclosure, optionally, the determination device and the sample to be tested are connected via a communication bus having the same number as the equipment number. This enables the number of bits of the communication bus to match the number of bits of the device number.
In the test platform according to the first aspect of the present disclosure, optionally, the determining device further includes a storage module configured to store the device number, the physical address, and a correspondence between the device number and the physical address. Thus, it is possible to facilitate determination of the device storage apparatus number, the physical address, and the correspondence between the apparatus number and the physical address.
In the test platform according to the first aspect of the present disclosure, optionally, the memory further records a reading time when the electrochemical parameter is read. This makes it possible to obtain a corresponding reading time when the electrochemical parameter is read.
In the test platform according to the first aspect of the present disclosure, optionally, the determining device includes a timing module for timing, and when the time of the timing module reaches a preset time, the determining device sends a data transmission signal to the sample to be tested; and the sample to be tested receives the data transmission signal, and the sample to be tested sends a transmission data packet including the reading time and the electrochemical parameters under the reading time to the judgment device. Therefore, the judgment device can obtain the electrochemical parameters of each sample to be detected in the preset time.
According to the electrochemical parameter testing platform, the consistency of the electrochemical parameters obtained by a plurality of samples to be tested can be judged quickly, and the electrochemical parameter testing efficiency can be improved.
Detailed Description
Hereinafter, preferred embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. In the following description, the same components are denoted by the same reference numerals, and redundant description thereof is omitted. The drawings are schematic and the ratio of the dimensions of the components and the shapes of the components may be different from the actual ones.
In addition, the headings and the like referred to in the following description of the present disclosure are not intended to limit the content or scope of the present disclosure, but merely serve as a reminder for reading. Such a subtitle should neither be understood as a content for segmenting an article, nor should the content under the subtitle be limited to only the scope of the subtitle.
(platform for testing electrochemical parameters)
Fig. 1 is a schematic structural diagram of a platform for testing electrochemical parameters according to the present disclosure. Fig. 2 is a schematic top view of a platform for testing electrochemical parameters in accordance with the present disclosure. The electrochemical parameter testing platform 1 of the present disclosure may be suitable for batch testing of consistency of electrochemical parameters of a plurality of samples 10 to be tested. In the present disclosure, the test platform 1 for electrochemical parameters may be referred to simply as test platform 1.
In some examples, as shown in fig. 1, the testing platform 1 may include a plurality of samples to be tested 10, a carrier device 20, and a determination device 30. The number of the samples 10 to be measured may be n, where n represents the number of the samples 10 to be measured, and n is a natural number. As shown in fig. 2, the n samples 10 to be measured may be arranged in a row, and the example of the present disclosure is not limited thereto, and the n samples 10 to be measured may also be arranged in a matrix or other shapes. The carrier 20 may contain a reaction solution with which the sensing parts 11 (described later) of the plurality of samples 10 to be measured are brought into contact and electrochemically reacted. The sample to be measured 10 may transmit the electrochemical parameters of the generated reaction solution to the determination device 30 through the communication bus.
(sample to be tested)
In some examples, as shown in fig. 1 or fig. 2, the number of samples 10 to be tested may be n, which is a natural number. For example, the number n of samples 10 to be tested may be, for example, 10, 20, 50, 100, 200. In addition, the number of samples 10 to be measured may also be 200 or more, but examples of the present disclosure are not limited thereto.
Fig. 3 is a block diagram of a test sample according to the present disclosure. Fig. 4 is a schematic view of a sample to be tested according to the present disclosure. Fig. 5 is a schematic view of a sample to be tested and a carrying device according to the present disclosure.
In some examples, as shown in fig. 3, the sample 10 to be tested may include a sensing portion 11. For example, the sensing part 11 shown in fig. 4 may be located at the bottom of the sample 10 to be measured. During the test, as shown in fig. 5, the sensing part 11 of the sample 10 to be tested may contact with a reaction solution in the carrier 20 (described later) to perform an electrochemical reaction, and detect an electrochemical parameter of the reaction solution. In other words, the sample 10 to be tested may be provided with the sensor portion 11 for detecting the electrochemical parameters of the reaction solution during the test.
In some examples, the sensing portion 11 may be a working electrode (not shown) of the sample 10 to be measured. The working electrode may include a sensing layer capable of reacting with the reaction solution. For example, when the reaction solution is a glucose solution, the sensing layer of the working electrode may be a glucolase sensing layer. The glucolase sensing layer of the sensing portion 11 can electrochemically react with the glucose solution and detect the concentration of the glucose solution.
Examples of the disclosure are not limited thereto. The sensing layer of the sensing part 11 can be replaced with replacement of the reaction solution. For example, when the reaction solution is a drug solution, the sensing layer of the sensing part 11 may be replaced with a corresponding reactant so that the sensing part 11 obtains a concentration of a certain drug in the drug solution. For example, antibiotics (e.g., gentamicin, vancomycin, and the like), digitoxin, digoxin, theophylline, and warfarin (warfarin), and the like.
In some examples, the sensing layer may react with the reaction solution to generate a current signal. The sensing portion 11 can acquire and transmit the current signal.
In some examples, the sample 10 to be tested may also include an electronic system (not shown). The sensing part 11 may transmit the current signal to an electronic system, and the electronic system processes the current signal to obtain an electrochemical parameter of the reaction solution, such as glucose concentration.
In some examples, as shown in fig. 3, the sample 10 to be tested may include a memory 12. The memory 12 may store electrochemical parameters of the reaction solution processed by the electronic system. The electrochemical parameters are obtained by processing current signals generated by the reaction of the sensing part 11 and the reaction solution through an electronic system. In other words, the memory 12 may be used for recording the electrochemical parameters read by the sensing portion 11.
In some examples, Memory 12 may be a high-speed RAM Memory, a non-volatile Memory (non-volatile Memory) or a Read-Only Memory (ROM).
In some examples, the sample 10 to be tested may have a specified number of bits of physical address (MAC address). The MAC address may be referred to as a physical address or a hardware address. The MAC address may be used to define the location of the sample 10 to be tested. In other words, the sample 10 to be tested can be identified by the MAC address. The MAC address is 48 bits in length. That is, the prescribed number of bits of the MAC address may be, for example, 48 bits. Typically, one sample 10 to be tested has a globally unique MAC address, and the MAC address is fixed. It can be seen that the respective sample 10 to be tested can be identified by the MAC address.
In some examples, as shown in fig. 3, the sample 10 to be tested may include a clock portion 13. The clock section 13 may be used for timing. The clock sections 13 of the respective samples 10 to be measured are synchronized with each other. Therefore, the electrochemical parameters of the samples 10 to be tested can be synchronously acquired. The synchronization method of the clock section 13 will be described later in detail.
In some examples, the electrochemical parameters read by the sample 10 to be tested and the corresponding reading time of the clock part 13 may also be stored in the memory 12. That is, the memory 12 may also record the read time when the electrochemical parameter is read. In this case, the sample 10 to be tested can obtain the corresponding reading moment when the electrochemical parameters are read.
Fig. 6 is a block diagram of a carrier device according to the present disclosure. In some examples, the test platform 1 may include a carrier 20. As shown in fig. 6, the carrier 20 may include a receiving portion 21 that receives the reaction solution. The number of the accommodating portions 21 may be plural. The different containers 21 may contain the same kind of reaction solution at the same concentration, or may contain the same kind of reaction solution at different concentrations. Examples of the present disclosure are not limited thereto, and different containers 21 may contain different kinds of reaction solutions, for example, the reaction solutions may include, but are not limited to, a glucose solution or the above-described drug solution. Examples of the disclosure are not limited thereto. In addition, the external environment in which the reaction solution in the housing portion 21 is exposed is kept constant.
In some examples, as shown in fig. 6, the carrier 20 may include a stand 22. The holder 22 may be used to place a plurality of samples 10 to be measured so that the sensing part 11 of the samples 10 to be measured is in contact with the reaction solution of the receiving part 21. The reaction solutions in contact with the sensor portions 11 of the respective samples 10 are the same reaction solution having the same concentration.
In some examples, the test platform 1 may comprise the determination device 30. The determination device 30 may be connected to a plurality of samples 10 to be measured. And the judging means 30 may assign an equipment number having a number of bits smaller than the prescribed number of bits of the physical address to each sample 10 to be tested, based on the physical address (MAC address) of the sample 10 to be tested.
In some examples, the determination device 30 may be connected to a plurality of samples 10 to be measured through a communication bus (communication interface) having the same number as that of the equipment to realize data transmission. Specifically, the plurality of samples to be measured 10 may respectively transmit the communication request signal and the corresponding MAC address to the determination device 30, and the determination device 30 may set the address signal and the device number having the number of bits smaller than the prescribed number of bits of the physical address based on the communication request signal and the corresponding MAC address feedback. Each sample 10 may receive a corresponding device number and store the device number in the memory 12 of the corresponding sample 10 for subsequent communication with the determination device 30. The number of bits of the device number may be the same as the number of bits of the communication bus (communication interface), and for example, when the communication bus (communication interface) is 8 bits, the number of bits of the device number is also 8 bits. In this case, identifying the corresponding sample to be tested 10 by the device number and obtaining the electrochemical parameter of the sample to be tested 10 is more efficient than identifying the corresponding sample to be tested 10 by the MAC address and obtaining the electrochemical parameter of the sample to be tested 10.
In some examples, the sample under test 10 may send a transmission data packet containing the device number and the electrochemical parameters to the determination device 30 during the testing process. That is, during the test, the sample 10 to be tested may form a transmission data packet by using the received device number and the corresponding electrochemical parameter in the memory 12, and send the transmission data packet to the determining device 30.
In some examples, the determination device 30 may determine the consistency of the electrochemical parameters obtained from each of the samples 10 to be tested based on the transmission data packet. Specifically, the determination device 30 may receive the transmission data packet and obtain the device number and the electrochemical parameter in the transmission data. The determining device 30 can analyze the electrochemical parameters of the samples 10 to be tested corresponding to different equipment numbers at the same time to determine the consistency of the electrochemical parameters obtained by each sample 10 to be tested.
Fig. 7 is a block diagram of a determination device according to the present disclosure. In some examples, as shown in fig. 7, the determining device 30 may include a timing module 31. The timing module 31 may be used to synchronize the respective clock sections 13. Thus, the timing module 31 can ensure that the clock units 13 of the plurality of samples 10 to be measured are synchronized with each other.
In some examples, the timing module 31 may synchronize each sample 10 to be tested every predetermined period of time. Wherein the predetermined time period may be, but is not limited to, for example, 20min, 30min, or 1 h. The preset time period may be internally set by the judgment means 30. In addition, the preset time period may be fixed or adjustable. This can further ensure that the clock units 13 of the plurality of samples 10 to be measured are synchronized with each other.
Fig. 8 is a flowchart illustrating a synchronization method of a timing module of the determination device according to the present disclosure. In some examples, as shown in fig. 8, the synchronization method of the timing module 31 may include selecting one sample 10 to be measured as a standard sample (step S100), resetting the time of the clock part 13 of the standard sample (step S200), and synchronizing the time of each sample 10 to be measured based on the time of the standard sample (step S300).
Specifically, in step S100, the timing module 31 may select any one of the samples 10 to be measured among the plurality of samples 10 to be measured as the standard sample. In step S200, the timing module 31 may send a "reset time command" signal to the standard sample, and after the standard sample receives the "reset time command" signal, the corresponding clock portion 13 may be reset to implement time resetting of the standard sample. In step S300, the timing module 31 may transmit a timing signal to the standard sample. The standard sample may transmit the time of the corresponding clock part 13 to the timing module 31 after receiving the time signal. The timing module 31 can receive the time of the standard sample and synchronize the time of each sample 10 to be measured based on the time of the standard sample. Thus, the time synchronization of each sample to be measured 10 and the standard sample can be ensured.
In step S300, the timing module 31 may acquire the time of the clock part 13 of the standard sample and use the time of the clock part 13 of the standard sample as the target time in the time synchronization of each sample 10 to be measured. The timing module 31 may synchronize the time of each of the samples 10 to be measured other than the standard sample among the plurality of samples 10 to be measured to the target time. Thus, the time of each sample 10 to be measured can be further ensured to be synchronized with the target time of the standard sample.
In some examples, as shown in fig. 7, the determination device 30 may include a storage module 32. The storage module 32 may be used to store the device number, the MAC address, and the correspondence between the device number and the physical address. Specifically, the storage module 32 may store the MAC address of the sample 10 to be tested sent to the determination device 30. In addition, the storage module 32 may store a correspondence between the device number and the physical address, and the determination device 30 may assign a device number having a smaller number of bits than a prescribed number of bits of the physical address to each sample 10 to be tested, based on the physical address (MAC address) of the sample 10 to be tested and the correspondence in the storage module 32. Thus, the storage module 32 can facilitate the determination device 30 to store the device number, the physical address, and the correspondence relationship between the device number and the physical address.
In some examples, the storage module 32 may be a high-speed RAM Memory, a non-volatile Memory (non-volatile Memory) or a Read-Only Memory (ROM).
In some examples, as shown in fig. 7, the determining device 30 may further include a data checking module 33. The transmission data packet formed by the sample 10 to be tested may also include a check code. The data verification module 33 may verify the data of the electrochemical parameters in the transmitted data packet based on the verification code.
Specifically, the determination device 30 may send a data signal reporting instruction to the sample 10 to be tested. The sample 10 to be tested may send a transmission data packet to the determination device 30 after receiving the instruction. After the determining device 30 receives the transmission data packet, the data checking module 33 may check whether the content of the transmission data packet is correct, if the content is correct, the determining device 30 may feed back a "success signal" to the sample 10 to be detected, if the content is incorrect, the determining device 30 may feed back a "retransmission signal" to the sample 10 to be detected, and after the sample 10 to be detected receives the "retransmission signal", the transmission data packet may be retransmitted. Therefore, the correctness of the transmitted data packet can be ensured.
In some examples, the data checking module 33 may check in a manner selected from at least one of parity check, cyclic redundancy check, longitudinal redundancy check, gray code check, sum check, and xor check. Therefore, the correctness of the transmitted data packet can be further ensured.
In some examples, as shown in fig. 7, the determination device 30 may include a timing module 34. The timing module 34 may be used for timing. The determining device 30 may send a data signal reporting command to the sample 10 to be measured at a preset time or at set intervals, so as to obtain a transmission data packet of the sample 10 to be measured, and further perform the determination of the consistency of the electrochemical parameters. The timing module 34 may be a timing chip. The preset time or the set time may be internally set by the judgment means 30. In addition, the preset time or the set time may be fixed or adjustable.
Specifically, when the time of the timing module 34 reaches the preset time, the determining device 30 may send a data transmission signal (i.e. the above-mentioned "data signal reporting instruction") to the sample 10 to be tested. The sample to be tested 10 may receive the data transmission signal and transmit a transmission data packet including the reading time and the electrochemical parameter at the reading time to the determination device 30. Thereby, the determination device 30 can obtain the electrochemical parameters of each sample 10 to be measured at a preset time.
In some examples, the transmission data packet formed by the sample 10 to be tested may further include a reading time for reading the electrochemical parameter. Therefore, the transmission data packet obtained by the determination device 30 may be a transmission data packet including the device number, the electrochemical parameter, the reading time when the electrochemical parameter is read, and the check code of each sample 10 to be measured. After the determining device 30 receives the transmission data packet of each sample 10 to be measured, a plurality of waveform diagrams with the electrochemical parameters as longitudinal coordinates and the reading time as transverse coordinates can be formed based on the device number, the electrochemical parameters and the reading time in the transmission data packet, and the consistency of the electrochemical parameters obtained by each sample 10 to be measured can be determined according to the waveform diagrams.
In the present disclosure, the carrier 20 may have a receiving portion 21 for receiving a reaction solution and a holder 22 for holding a plurality of samples 10 to be measured. The sensing portions 11 of the plurality of samples to be measured 10 can detect electrochemical parameters of the reaction solution. The sample 10 to be tested may have a specified number of physical addresses and a memory 12 for recording electrochemical parameters. The determination device 30 may be connected to a plurality of samples 10 to be tested, and assign an equipment number having a number of bits smaller than a prescribed number of bits of the physical address to each sample 10 to be tested according to the physical address of the sample 10 to be tested. During the test, the sample 10 to be tested may send a transmission data packet containing the device number and the electrochemical parameters to the determination device 30. The determination device 30 may determine the consistency of the electrochemical parameters obtained from the respective samples 10 to be tested based on the transmission data packet. Under the condition, the corresponding electrochemical parameters of the samples 10 to be tested can be obtained according to the equipment numbers, so that the consistency of the electrochemical parameters of a plurality of samples 10 to be tested can be quickly judged, and the test efficiency of batch test is improved.