CN104758843A - Traditional Chinese medicine preparation for treating hyperlipidemia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating hyperlipidemia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine preparation for treating hyperlipidemia and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is prepared from the following raw materials: glossy privet fruits, rhizoma atractylodis, rhizoma alismatis, semen cassia, polygonum multiflorum, radix polygonati officinalis, Curcuma aromatica, caltrop, semen sesami nigrum, poria cocos, salviae miltiorrhizae, cistanche, polygala tenuifolia, mulberry fruits, honey, dried tangerine and liquorice. The finished product preparation prepared from the raw materials through a production process disclosed by the invention has the curative advantages of quick acting, combination of regulation and treatment, high cure rate, no relapse after curing, no toxic or side effect and the like. In addition, the traditional Chinese medicine preparation further has the advantages that the preparation is small in individual efficacy difference and stable in efficacy, the preparation process is simple and feasible and the preparation process can be put into industrial mass production easily.
Description
Technical field
The invention provides a kind of Chinese medicine preparation for the treatment of hyperlipidemia and preparation method thereof, belong to tcm field.
Technical background
Hyperlipidemia is a kind of systemic disease, to refer in blood T-CHOL and/or triglyceride is too high or HDL-C is too low, and modern medicine is referred to as dyslipidemia.Cardinal symptom is: sclerosis of blood vessels, and blood plasma or serum muddiness, blood vessel a part forms speckle etc., and main harm causes atherosclerosis, and then cause numerous relevant diseases, and wherein modal a kind of fatal disease is exactly coronary heart disease.
The traditional Chinese medical science is thought, the generation of primary disease and the dirty relation of liver,spleen,kidney three are the closest, wherein especially with spleen, kidney for wanting, therefore will attract great attention, tcm syndrome differentiation and treatment is divided into following several:
1, insufficiency of the spleen leading to overabundance of dampness
Card is shown in that gastral cavity abdominal distention is vexed, anorexia, nausea nausea, tastelessness and no thirst, abdominal pain diarrhea, and head heavy sensation of the body is stranded, enlarged tongue, and tongue is greasy in vain, and soft pulse is sliding.Controlling should invigorating the spleen for eliminating dampness.
2, insufficiency of vital energy and blood
Card is shown in deficiency of QI with disinclination to talk, weak spontaneous perspiration, pale or sallow complexion, palpitation and insomnia, light red tongue and tender, thready and weak pulse.Controlling should qi and blood tonifying.
3, stagnation of turbid phlegm in middle-JIAO
Card is shown in the vertigo, has a headache nose heave, chest distress and palpitation symptoms, inappetence, vomiting and nausea sputum, and limbs are tired heavy, or see that body is plump, or amenorrhea, white and greasy fur, rolling pulse.Control and should damp eliminating reduce phlegm.
Summary of the invention
The technical problem to be solved in the present invention is invention Chinese medicine preparation, makes it have good therapeutic effect to hyperlipidemia.
For solving the problems of the technologies described above, the technical scheme that inventor takes is: utilize modern pharmaceutical technology and preparation technique, the dosage of traditional medicine, dosage form and medicining mode are transformed, the technical requirement of modern processing technique is accessed while medicine prescription under development, again through inspection, the adjustment of clinical practice, finally, inventor obtains a Chinese prescription and a set of production technology matched with it, and this Chinese prescription is as follows with the performance of the form of weight portion:
Fructus Ligustri Lucidi 17-29 part, Rhizoma Atractylodis 10-22 part, Rhizoma Alismatis 9-21 part, Semen Cassiae 11-25 part, Radix Polygoni Multiflori 8-20 part, Rhizoma Polygonati Odorati 12-24 part, Radix Curcumae 7-17 part, Fructus Tribuli 9-21 part, Semen Sesami Nigrum 15-29 part, Poria 10-22 part, Radix Salviae Miltiorrhizae 8-16 part, Herba Cistanches 6-10 part, Radix Polygalae 7-15 part, Fructus Mori 18-34 part, Mel 7-17 part, Pericarpium Citri Reticulatae 8-18 part, Radix Glycyrrhizae 8-14 part.
This Chinese prescription is preferably the proportioning of following 3 curative effect the bests by clinical practice:
Proportioning 1: Fructus Ligustri Lucidi 23 parts, Rhizoma Atractylodis 16 parts, Rhizoma Alismatis 15 parts, Semen Cassiae 18 parts, Radix Polygoni Multiflori 14 parts, Rhizoma Polygonati Odorati 18 parts, Radix Curcumae 12 parts, Fructus Tribuli 15 parts, Semen Sesami Nigrum 22 parts, 16 parts, Poria, Radix Salviae Miltiorrhizae 12 parts, Herba Cistanches 8 parts, Radix Polygalae 11 parts, Fructus Mori 26 parts, Mel 12 parts, Pericarpium Citri Reticulatae 13 parts, 11 parts, Radix Glycyrrhizae.
Proportioning 2: Fructus Ligustri Lucidi 25 parts, Rhizoma Atractylodis 18 parts, Rhizoma Alismatis 16 parts, Semen Cassiae 17 parts, Radix Polygoni Multiflori 15 parts, Rhizoma Polygonati Odorati 17 parts, Radix Curcumae 11 parts, Fructus Tribuli 14 parts, Semen Sesami Nigrum 20 parts, 15 parts, Poria, Radix Salviae Miltiorrhizae 13 parts, Herba Cistanches 9 parts, Radix Polygalae 12 parts, Fructus Mori 27 parts, Mel 13 parts, Pericarpium Citri Reticulatae 14 parts, 12 parts, Radix Glycyrrhizae.
Proportioning 3: Fructus Ligustri Lucidi 24 parts, Rhizoma Atractylodis 17 parts, Rhizoma Alismatis 14 parts, Semen Cassiae 19 parts, Radix Polygoni Multiflori 16 parts, Rhizoma Polygonati Odorati 18 parts, Radix Curcumae 13 parts, Fructus Tribuli 16 parts, Semen Sesami Nigrum 23 parts, 15 parts, Poria, Radix Salviae Miltiorrhizae 13 parts, Herba Cistanches 7 parts, Radix Polygalae 13 parts, Fructus Mori 28 parts, Mel 11 parts, Pericarpium Citri Reticulatae 14 parts, 12 parts, Radix Glycyrrhizae.
The preparation technology of Chinese medicine preparation of the present invention is following steps:
(1) each taste Chinese crude drug is taken by Chinese prescription of the present invention;
(2) by Rhizoma Atractylodis, Radix Polygoni Multiflori, Radix Glycyrrhizae parch, pulverize respectively, levigate, cross 80-120 mesh sieve, obtain fine powder a, for subsequent use;
(3) Semen Cassiae, Fructus Tribuli, Semen Sesami Nigrum, Poria, Radix Salviae Miltiorrhizae, Herba Cistanches are pulverized respectively, grinding, cross 80-120 mesh sieve, obtain fine powder b, for subsequent use;
(4) Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Fructus Mori, Rhizoma Alismatis, Radix Curcumae, Radix Polygalae, Pericarpium Citri Reticulatae are pulverized respectively, after mixing, add the purified water of 6-13 times of weight, backflow decoction three times, each 1-4 hour, filters, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.23-1.26, for subsequent use;
(5) concentrated solution obtained in step (4) is added Mel, mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, and drying under reduced pressure, obtains dry extract, pulverizes levigate, crosses 80-120 mesh sieve, obtains fine powder c;
(6) by fine powder a, b, c mix homogeneously, utilize modern general Chinese medicine preparation technology, make the Chinese medicine finished product preparation of clinical needs, the dosage forms such as such as tablet, granule, tincture, powder, pill, capsule, syrup.
The character of Chinese crude drug involved in Chinese prescription of the present invention and function:
Fructus Ligustri Lucidi: this product is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi.Sweet in the mouth, hardship, cool in nature; Return liver, kidney channel; Nourishing the liver and kidney, improving eyesight black hair.
Rhizoma Atractylodis: this product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. or Atractylis chinensis.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
Rhizoma Alismatis: this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.Sweet in the mouth, cold in nature; Return kidney, urinary bladder channel; Diuresis, clearing away damp-heat.
Semen Cassiae: this product is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae.Sweet in the mouth, hardship, salty, cold nature; Return liver, large intestine channel; Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.
Radix Polygoni Multiflori: this product is the dried root of polygonum multiflorum thunb, and its rattan claims " Caulis Polygoni Multiflori ".Bitter in the mouth, sweet, puckery; Slightly warm in nature; Return liver, kidney channel; Nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispels the wind, removing toxic substances.
Rhizoma Polygonati Odorati: this product is the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati.Sweet in the mouth, cold nature; Attach to the lung and stomach meridians; Nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.
Radix Curcumae: this product is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.Acrid in the mouth, hardship, cold in nature; Return liver, the heart, lung meridian; Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
Fructus Tribuli: this product is the dry mature fruit of zygophyllaceae plant Fructus Tribuli.Acrid in the mouth, hardship, slightly warm in nature; Return Liver Channel; Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.
Semen Sesami Nigrum: this product is the dry mature seed of Pedaliaceae (Pedaliaceae) Sesamum plant sesame.Sweet in the mouth, property is put down; Return liver, kidney, large intestine channel; Invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.
Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, spleen, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Bitter in the mouth, cold nature; GUIXIN, Liver Channel; Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Herba Cistanches: this product is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche.Sweet in the mouth, salty, warm in nature; Return kidney, large intestine channel; Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.
Radix Polygalae: this product is the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.Bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian; To calm the nerves Fructus Alpiniae Oxyphyllae, eliminate the phlegm, detumescence.
Fructus Mori: this product is the dry fruit ear of moraceae plants Mulberry.Sweet in the mouth, acid, cold in nature; GUIXIN, liver, kidney channel; To enrich blood YIN nourishing, promote the production of body fluid and moisturize.
Mel: the honey of Mel nectar brew in Nidus Vespae that to be Apis adopt from the spending of flowering plant.Sweet in the mouth, property is put down; Enter spleen, stomach, lung, large intestine channel; Harmonizing the spleen and stomach, relieving spasm to stop pain, nourishing the lung to arrest cough, loosening bowel to relieve constipation, skin moistening granulation promoting, removing toxic substances.
Pericarpium Citri Reticulatae: be the mature peel of rutaceae orange and variety thereof.Bitter in the mouth, pungent, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The side of Chinese prescription of the present invention separates:
The prescription of Chinese medicine preparation of the present invention is with Fructus Ligustri Lucidi, Semen Sesami Nigrum, Fructus Mori, Semen Cassiae, Rhizoma Polygonati Odorati for monarch drug, nourishing liver and kidney, YIN nourishing of enriching blood, clearing heat and moistening dryness, promoting the production of body fluid to quench thirst; With Rhizoma Atractylodis, Rhizoma Alismatis, Fructus Tribuli, Poria for ministerial drug, drying damp and strengthening spleen, wet clearly diuretic, suppressing the hyperactive liver resolving depression, invigorating the spleen and regulating the stomach; With Radix Polygoni Multiflori, Radix Curcumae, Herba Cistanches, Radix Polygalae for adjuvant drug, nourishing the blood and yin, regulating qi to disperse stagnation, loosening bowel to relieve constipation, eliminating phlegm for diminishing swelling; With Radix Salviae Miltiorrhizae, Mel, Pericarpium Citri Reticulatae for making medicine, promoting blood circulation to restore menstrual flow, harmonizing the spleen and stomach, regulating qi-flowing for strengthening spleen; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, make that all medicines complement each other, synergism, jointly reach nourishing liver and kidney, YIN nourishing of enriching blood, clearing heat and moistening dryness, eliminating phlegm for diminishing swelling, the effect such as wet clearly diuretic, suppressing the hyperactive liver resolving depression, promoting blood circulation to restore menstrual flow, regulating qi-flowing for strengthening spleen, to the treatment of hyperlipidemia, there is very significant therapeutic effect.
Compared with prior art, Chinese medicine preparation of the present invention has instant effect, medical treatment combines, high, the non-relapse after healing of cure rate, the treatment advantage such as without any side effects, in addition, it also has that preparation drug effect individual variation is little, preparation efficacy stability, preparation process are simple and easy to do, preparation process is easy to industrialized mass production.
Detailed description of the invention
Embodiment 1
Maximum and best technological parameter production granule by each medical material weight range of Chinese prescription of the present invention:
(1) Fructus Ligustri Lucidi 2900g, Rhizoma Atractylodis 2200g, Rhizoma Alismatis 2100g, Semen Cassiae 2500g, Radix Polygoni Multiflori 2000g, Rhizoma Polygonati Odorati 2400g, Radix Curcumae 1700g, Fructus Tribuli 2100g, Semen Sesami Nigrum 2900g, Poria 2200g, Radix Salviae Miltiorrhizae 1600g, Herba Cistanches 1000g, Radix Polygalae 1500g, Fructus Mori 3400g, Mel 1700g, Pericarpium Citri Reticulatae 1800g, Radix Glycyrrhizae 1400g is taken by Chinese prescription of the present invention;
(2) by Rhizoma Atractylodis, Radix Polygoni Multiflori, Radix Glycyrrhizae parch, pulverize respectively, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) Semen Cassiae, Fructus Tribuli, Semen Sesami Nigrum, Poria, Radix Salviae Miltiorrhizae, Herba Cistanches are pulverized respectively, grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Fructus Mori, Rhizoma Alismatis, Radix Curcumae, Radix Polygalae, Pericarpium Citri Reticulatae are pulverized respectively, after mixing, add the purified water of 9 times of weight, backflow decoction three times, each 3 hours, filter, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.23-1.26, for subsequent use;
(5) concentrated solution obtained in step (4) is added Mel, mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, and drying under reduced pressure, obtains dry extract, pulverizes levigate, crosses 100 mesh sieves, obtains fine powder c;
(6) by fine powder a, b, c mix homogeneously, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.56g crude drug/g granule.
Embodiment 2
Minima and best technological parameter production granule by each medical material weight range of Chinese prescription of the present invention:
(1) Fructus Ligustri Lucidi 1700g, Rhizoma Atractylodis 1000g, Rhizoma Alismatis 900g, Semen Cassiae 1100g, Radix Polygoni Multiflori 800g, Rhizoma Polygonati Odorati 1200g, Radix Curcumae 700g, Fructus Tribuli 900g, Semen Sesami Nigrum 1500g, Poria 1000g, Radix Salviae Miltiorrhizae 800g, Herba Cistanches 600g, Radix Polygalae 700g, Fructus Mori 1800g, Mel 700g, Pericarpium Citri Reticulatae 800g, Radix Glycyrrhizae 800g is taken by Chinese prescription of the present invention;
(2) by Rhizoma Atractylodis, Radix Polygoni Multiflori, Radix Glycyrrhizae parch, pulverize respectively, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) Semen Cassiae, Fructus Tribuli, Semen Sesami Nigrum, Poria, Radix Salviae Miltiorrhizae, Herba Cistanches are pulverized respectively, grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Fructus Mori, Rhizoma Alismatis, Radix Curcumae, Radix Polygalae, Pericarpium Citri Reticulatae are pulverized respectively, after mixing, add the purified water of 9 times of weight, backflow decoction three times, each 3 hours, filter, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.23-1.26, for subsequent use;
(5) concentrated solution obtained in step (4) is added Mel, mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, and drying under reduced pressure, obtains dry extract, pulverizes levigate, crosses 100 mesh sieves, obtains fine powder c;
(6) by fine powder a, b, c mix homogeneously, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.56g crude drug/g granule.
Embodiment 3
Granule is produced by the arbitrary value in each medical material weight range of Chinese prescription of the present invention and best technological parameter:
(1) Fructus Ligustri Lucidi 1800g, Rhizoma Atractylodis 2100g, Rhizoma Alismatis 1100g, Semen Cassiae 2200g, Radix Polygoni Multiflori 1200g, Rhizoma Polygonati Odorati 2300g, Radix Curcumae 900g, Fructus Tribuli 2000g, Semen Sesami Nigrum 1700g, Poria 2100g, Radix Salviae Miltiorrhizae 1100g, Herba Cistanches 800g, Radix Polygalae 800g, Fructus Mori 3300g, Mel 900g, Pericarpium Citri Reticulatae 1600g, Radix Glycyrrhizae 1000g is taken by Chinese prescription of the present invention;
(2) by Rhizoma Atractylodis, Radix Polygoni Multiflori, Radix Glycyrrhizae parch, pulverize respectively, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) Semen Cassiae, Fructus Tribuli, Semen Sesami Nigrum, Poria, Radix Salviae Miltiorrhizae, Herba Cistanches are pulverized respectively, grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Fructus Mori, Rhizoma Alismatis, Radix Curcumae, Radix Polygalae, Pericarpium Citri Reticulatae are pulverized respectively, after mixing, add the purified water of 9 times of weight, backflow decoction three times, each 3 hours, filter, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.23-1.26, for subsequent use;
(5) concentrated solution obtained in step (4) is added Mel, mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, and drying under reduced pressure, obtains dry extract, pulverizes levigate, crosses 100 mesh sieves, obtains fine powder c;
(6) by fine powder a, b, c mix homogeneously, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.56g crude drug/g granule.
Embodiment 4
Ratio and best technological parameter production granule in Chinese prescription optimum ratio 1 of the present invention:
(1) Fructus Ligustri Lucidi 2300g, Rhizoma Atractylodis 1600g, Rhizoma Alismatis 1500g, Semen Cassiae 1800g, Radix Polygoni Multiflori 1400g, Rhizoma Polygonati Odorati 1800g, Radix Curcumae 1200g, Fructus Tribuli 1500g, Semen Sesami Nigrum 2200g, Poria 1600g, Radix Salviae Miltiorrhizae 1200g, Herba Cistanches 800g, Radix Polygalae 1100g, Fructus Mori 2600g, Mel 1200g, Pericarpium Citri Reticulatae 1300g, Radix Glycyrrhizae 1100g is taken by Chinese prescription of the present invention;
(2) by Rhizoma Atractylodis, Radix Polygoni Multiflori, Radix Glycyrrhizae parch, pulverize respectively, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) Semen Cassiae, Fructus Tribuli, Semen Sesami Nigrum, Poria, Radix Salviae Miltiorrhizae, Herba Cistanches are pulverized respectively, grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Fructus Mori, Rhizoma Alismatis, Radix Curcumae, Radix Polygalae, Pericarpium Citri Reticulatae are pulverized respectively, after mixing, add the purified water of 9 times of weight, backflow decoction three times, each 3 hours, filter, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.23-1.26, for subsequent use;
(5) concentrated solution obtained in step (4) is added Mel, mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, and drying under reduced pressure, obtains dry extract, pulverizes levigate, crosses 100 mesh sieves, obtains fine powder c;
(6) by fine powder a, b, c mix homogeneously, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.56g crude drug/g granule.
Embodiment 5
Ratio and best technological parameter production granule in Chinese prescription optimum ratio 2 of the present invention:
(1) Fructus Ligustri Lucidi 2500g, Rhizoma Atractylodis 1800g, Rhizoma Alismatis 1600g, Semen Cassiae 1700g, Radix Polygoni Multiflori 1500g, Rhizoma Polygonati Odorati 1700g, Radix Curcumae 1100g, Fructus Tribuli 1400g, Semen Sesami Nigrum 2000g, Poria 1500g, Radix Salviae Miltiorrhizae 1300g, Herba Cistanches 900g, Radix Polygalae 1200g, Fructus Mori 2700g, Mel 1300g, Pericarpium Citri Reticulatae 1400g, Radix Glycyrrhizae 1200g is taken by Chinese prescription of the present invention;
(2) by Rhizoma Atractylodis, Radix Polygoni Multiflori, Radix Glycyrrhizae parch, pulverize respectively, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) Semen Cassiae, Fructus Tribuli, Semen Sesami Nigrum, Poria, Radix Salviae Miltiorrhizae, Herba Cistanches are pulverized respectively, grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Fructus Mori, Rhizoma Alismatis, Radix Curcumae, Radix Polygalae, Pericarpium Citri Reticulatae are pulverized respectively, after mixing, add the purified water of 9 times of weight, backflow decoction three times, each 3 hours, filter, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.23-1.26, for subsequent use;
(5) concentrated solution obtained in step (4) is added Mel, mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, and drying under reduced pressure, obtains dry extract, pulverizes levigate, crosses 100 mesh sieves, obtains fine powder c;
(6) by fine powder a, b, c mix homogeneously, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.56g crude drug/g granule.
Embodiment 6
Ratio and best technological parameter production granule in Chinese prescription optimum ratio 3 of the present invention:
(1) Fructus Ligustri Lucidi 2400g, Rhizoma Atractylodis 1700g, Rhizoma Alismatis 1400g, Semen Cassiae 1900g, Radix Polygoni Multiflori 1600g, Rhizoma Polygonati Odorati 1800g, Radix Curcumae 1300g, Fructus Tribuli 1600g, Semen Sesami Nigrum 2300g, Poria 1500g, Radix Salviae Miltiorrhizae 1300g, Herba Cistanches 700g, Radix Polygalae 1300g, Fructus Mori 2800g, Mel 1100g, Pericarpium Citri Reticulatae 1400g, Radix Glycyrrhizae 1200g is taken by Chinese prescription of the present invention;
(2) by Rhizoma Atractylodis, Radix Polygoni Multiflori, Radix Glycyrrhizae parch, pulverize respectively, levigate, cross 100 mesh sieves, obtain fine powder a, for subsequent use;
(3) Semen Cassiae, Fructus Tribuli, Semen Sesami Nigrum, Poria, Radix Salviae Miltiorrhizae, Herba Cistanches are pulverized respectively, grinding, cross 100 mesh sieves, obtain fine powder b, for subsequent use;
(4) Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Fructus Mori, Rhizoma Alismatis, Radix Curcumae, Radix Polygalae, Pericarpium Citri Reticulatae are pulverized respectively, after mixing, add the purified water of 9 times of weight, backflow decoction three times, each 3 hours, filter, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.23-1.26, for subsequent use;
(5) concentrated solution obtained in step (4) is added Mel, mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, and drying under reduced pressure, obtains dry extract, pulverizes levigate, crosses 100 mesh sieves, obtains fine powder c;
(6) by fine powder a, b, c mix homogeneously, utilize modern general Chinese medicine preparation technology, make granule, specification: 0.56g crude drug/g granule.
The animal toxicity experiment of Chinese medicine preparation of the present invention
1, experimental drug: Chinese medicine granules obtained by embodiment of the present invention 1-6, specification: 0.56g crude drug/g granule.Test animal used: regular grade NIH mice, body weight 21g ± 4g, male and female half and half, female mice is all without pregnant; SD rat, original body mass 213 ± 9g, male and female half and half, female rats is all without pregnant.
2, acute toxicity testing
Application mice carries out acute toxicity testing and shows: mouse stomach Chinese medicine granules of the present invention, under 829.5g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 2 hours recover normal, Continuous Observation 7 days after administration, none is dead for mice, and overall health of patients, diet, takes the photograph water, urine and body weight and increase all normal.Experimental result shows: the maximum dosage-feeding of mouse stomach Chinese medicine granules of the present invention is 829.5g crude drug/kg/d(LD
50> 829.5g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.28g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 2962.5 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
3, long term toxicity test
Select SD rat, give the Chinese medicine granules of the present invention (180,60,20 times of clinical medicine dose) of Three doses: 50.4g crude drug/kg, 16.8g crude drug/kg, 5.6g crude drug/kg(per weight dosage is by 20 times of calculating of clinical application amount, and clinical application amount is according to the Pharmacopoeia of the People's Republic of China 2010 years versions one).Every day gavage once, continuous 90 days, after last administration 24 hours respectively group live and kill 1/2 animal (male and female half and half), all the other 1/2 animals continue that observations are alive after 2 weeks kills.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal; Within after administration 90 days, within 2 weeks, carry out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.
Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test: Chinese medicine preparation of the present invention has no significant effect rat in high, medium and low three dosage (50.4g crude drug/kg, 16.8g crude drug/kg, 5.6g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention very high.
The clinical trial of Chinese medicine preparation of the present invention
Hyperlipemic patients 200 is collected in this clinical trial altogether, age 32-65 year, wherein man 120, female 80, is divided into 4 groups by features such as age-based for all patients, sex, the state of an illness, often organizes 50 people, makes these 4 groups possess comparability on statistical significance.4 groups are numbered matched group, embodiment 4, embodiment 5, embodiment 6 groups respectively.
Diagnostic criteria with reference to Ministry of Public Health, the more old tackling key problem cooperative groups of State Administration of Traditional Chinese Medicine's traditional Chinese medical science are worked out: a, T-CHOL (TC) >=5.70mmlol/L; B, triglyceride (TG) >=1.7mmlol/L; C HDL-C (HDL-C) male≤1.03mmlol/L, women >=1.16mmlol/L; D, low-density lipoprotein cholesterol (LDL-C) >=5.70mmlol/L; More than 1 person and diagnosable is met in first three items.All patients, all meet diagnostic criteria above.
1, test drug
Contrast medicine: JIANGZHINING KELI, the accurate word Z22022958 of traditional Chinese medicines, Jilin Tianqiang Pharmaceutical Co., Ltd.;
Investigational agent: the granule that the embodiment of the present invention 4, embodiment 5, embodiment 6 are produced, specification: 0.56g crude drug/g granule.
2, test method
The oral JIANGZHINING KELI of matched group, each 4g, every day 3 times; Test 4-6 group is the granule produced of oral embodiment of the present invention 4-6 respectively, each 15g, every day 2 times; Within 3 weeks, be a course for the treatment of, treat 3 courses for the treatment of continuously.To monitor each patient before the treatment afterwards: blood fat, hemorheology, blood pressure, heart rate, electrocardio, three large conventional, liver functions.
3, judgment criteria
Criterion of therapeutical effect is with reference to " clinical drug research guideline ".
Effective: to reach 1 person, i.e. TC decline >=20%, TG decline >=40%, HDL-C rising >=0.26mmlol/L;
Effective: to reach 1 person, i.e. TC decline 10-20%, TG decline >=20-40%, HDL-C rising >=0.10-0.26mmlol/L;
Invalid: to check and do not reach efficiency index person.
4, result of the test
(1) matched group and test group before the treatment after blood lipid level compare, as shown in table 1:
Table 1 blood lipid level comparison sheet
(2) comparitive study of matched group and test group, as shown in table 2:
Table 2 comparitive study table
5, conclusion (of pressure testing)
(1) table 1 data display, treatment group, after treatment, serum TC, TG, TDL-C obviously reduce, and DHL-C obviously raises, and compare, all have significant difference (P < 0.01) with before treatment; Treatment group compares with matched group, improves in DHL-C be all obviously better than matched group (P < 0.01) at reduction TC, TG, TDL-C.
(2) table 2 data display, the average obvious effective rate (81.3%) of Chinese medicine preparation of the present invention is far away higher than matched group (30%); The average total effective rate (96%) of test group, is significantly higher than matched group (66%).
In sum, Chinese medicine preparation of the present invention has very significant technical advantage in treatment hyperlipidemia, obtains creationary technological achievement.
Claims (6)
1. treat a Chinese medicine preparation for hyperlipidemia, it is characterized in that being made up of the medical material of following weight portion: Fructus Ligustri Lucidi 17-29 part, Rhizoma Atractylodis 10-22 part, Rhizoma Alismatis 9-21 part, Semen Cassiae 11-25 part, Radix Polygoni Multiflori 8-20 part, Rhizoma Polygonati Odorati 12-24 part, Radix Curcumae 7-17 part, Fructus Tribuli 9-21 part, Semen Sesami Nigrum 15-29 part, Poria 10-22 part, Radix Salviae Miltiorrhizae 8-16 part, Herba Cistanches 6-10 part, Radix Polygalae 7-15 part, Fructus Mori 18-34 part, Mel 7-17 part, Pericarpium Citri Reticulatae 8-18 part, Radix Glycyrrhizae 8-14 part.
2. the Chinese medicine preparation for the treatment of hyperlipidemia as claimed in claim 1, is characterized in that being made up of the medical material of following weight portion: Fructus Ligustri Lucidi 23 parts, Rhizoma Atractylodis 16 parts, Rhizoma Alismatis 15 parts, Semen Cassiae 18 parts, Radix Polygoni Multiflori 14 parts, Rhizoma Polygonati Odorati 18 parts, Radix Curcumae 12 parts, Fructus Tribuli 15 parts, Semen Sesami Nigrum 22 parts, 16 parts, Poria, Radix Salviae Miltiorrhizae 12 parts, Herba Cistanches 8 parts, Radix Polygalae 11 parts, Fructus Mori 26 parts, Mel 12 parts, Pericarpium Citri Reticulatae 13 parts, 11 parts, Radix Glycyrrhizae.
3. the Chinese medicine preparation for the treatment of hyperlipidemia as claimed in claim 1, is characterized in that being made up of the medical material of following weight portion: Fructus Ligustri Lucidi 25 parts, Rhizoma Atractylodis 18 parts, Rhizoma Alismatis 16 parts, Semen Cassiae 17 parts, Radix Polygoni Multiflori 15 parts, Rhizoma Polygonati Odorati 17 parts, Radix Curcumae 11 parts, Fructus Tribuli 14 parts, Semen Sesami Nigrum 20 parts, 15 parts, Poria, Radix Salviae Miltiorrhizae 13 parts, Herba Cistanches 9 parts, Radix Polygalae 12 parts, Fructus Mori 27 parts, Mel 13 parts, Pericarpium Citri Reticulatae 14 parts, 12 parts, Radix Glycyrrhizae.
4. the Chinese medicine preparation for the treatment of hyperlipidemia as claimed in claim 1, is characterized in that being made up of the medical material of following weight portion: Fructus Ligustri Lucidi 24 parts, Rhizoma Atractylodis 17 parts, Rhizoma Alismatis 14 parts, Semen Cassiae 19 parts, Radix Polygoni Multiflori 16 parts, Rhizoma Polygonati Odorati 18 parts, Radix Curcumae 13 parts, Fructus Tribuli 16 parts, Semen Sesami Nigrum 23 parts, 15 parts, Poria, Radix Salviae Miltiorrhizae 13 parts, Herba Cistanches 7 parts, Radix Polygalae 13 parts, Fructus Mori 28 parts, Mel 11 parts, Pericarpium Citri Reticulatae 14 parts, 12 parts, Radix Glycyrrhizae.
5. prepare as arbitrary in claim 1-4 as described in the method for Chinese medicine preparation for the treatment of hyperlipidemia, it is characterized in that comprising the following steps:
(1) each taste Chinese crude drug is taken by Chinese prescription of the present invention;
(2) by Rhizoma Atractylodis, Radix Polygoni Multiflori, Radix Glycyrrhizae parch, pulverize respectively, levigate, cross 80-120 mesh sieve, obtain fine powder a, for subsequent use;
(3) Semen Cassiae, Fructus Tribuli, Semen Sesami Nigrum, Poria, Radix Salviae Miltiorrhizae, Herba Cistanches are pulverized respectively, grinding, cross 80-120 mesh sieve, obtain fine powder b, for subsequent use;
(4) Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Fructus Mori, Rhizoma Alismatis, Radix Curcumae, Radix Polygalae, Pericarpium Citri Reticulatae are pulverized respectively, after mixing, add the purified water of 6-13 times of weight, backflow decoction three times, each 1-4 hour, filters, merging filtrate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.23-1.26, for subsequent use;
(5) concentrated solution obtained in step (4) is added Mel, mix homogeneously, continuing to be concentrated into 60 DEG C of relative densities is the thick paste of 1.30-1.35, and drying under reduced pressure, obtains dry extract, pulverizes levigate, crosses 80-120 mesh sieve, obtains fine powder c;
(6) by fine powder a, b, c mix homogeneously, utilize modern general Chinese medicine preparation technology, make the Chinese medicine finished product preparation of clinical needs.
6. the Chinese medicine preparation of the treatment hyperlipidemia as described in as arbitrary in claim 1-4, is characterized in that: described Chinese medicine preparation is tablet, granule, tincture, powder, pill, capsule and syrup.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362965A (en) * | 2015-12-25 | 2016-03-02 | 青岛华之草医药科技有限公司 | Traditional Chinese medicine preparation for treating fatty liver |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742781A (en) * | 2004-08-31 | 2006-03-08 | 上海方心科技研究所 | Fat-reducing blood-fat-reducing Chinese medicine preparation |
| CN103656520A (en) * | 2013-12-17 | 2014-03-26 | 青岛中科菲力工程技术研发有限公司 | Traditional Chinese medicine composition for treating hyperlipidaemia |
-
2015
- 2015-04-17 CN CN201510181991.2A patent/CN104758843A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742781A (en) * | 2004-08-31 | 2006-03-08 | 上海方心科技研究所 | Fat-reducing blood-fat-reducing Chinese medicine preparation |
| CN103656520A (en) * | 2013-12-17 | 2014-03-26 | 青岛中科菲力工程技术研发有限公司 | Traditional Chinese medicine composition for treating hyperlipidaemia |
Non-Patent Citations (1)
| Title |
|---|
| 向楠: "《中药临床药理学》", 31 January 2010, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362965A (en) * | 2015-12-25 | 2016-03-02 | 青岛华之草医药科技有限公司 | Traditional Chinese medicine preparation for treating fatty liver |
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