CN104758663A - External-use liniment used for varicosity and application thereof - Google Patents

Abstract

The invention relates to an external-use liniment used for varicosity and an application thereof. The external-use liniment is prepare from following raw materials: rhizome chuanxiong, astragalus membranaceus, cortex phellodendri, spina gleditsiae, red peony roots, loofah sponge, folium isatidis, flos carthami, herba epimedii, ligustrum lucidum ait, poria cocos, dandelion, herba houttuyniae, cortex magnoliae officinalis, achyranthes bidentata, radix clematidis, kusnezoff monkshood roots, frankincense, myrrh, honey suckles, cassia twigs, oldenlandia diffusa, rhizome imperata cylindrica, dried root bark of mulberry trees, spina date seeds, semen cuscutae, monkshoods and liquorice. The medicine composition is strict in formula, is simple in preparation, is definite in curative effects aiming to the varicosity and has a wide prospect.

Description

For cirsoid externally applied liniment and application thereof

Technical field

The invention belongs to Chinese medicine technical field, concrete, relating to a kind of is that raw material is for cirsoid externally applied liniment and application thereof with Chinese herbal medicine.

Background technology

Varicosis refers to that the vein caused is tortuous, expansion due to factors such as blood stasis, vein tube wall weaknesses.All can there is varicose in the vein at the multiple position of health, such as hemorrhoid are exactly a kind of varicosis in fact, clinical visible esophagus fundus ventricularis varication, varicocele and abdominal wall varicosis etc. in addition.The position that varicosis the most often occurs is at lower limb.It is emphasized that varicosis itself may be the secondary manifestation of other pathological changes, as inaccessible in caval vein etc., answer positive treatment protopathy.Varicose veins of the lower extremity be patient's lower limb tube wall become book, superficial vein is thicker, in Lumbricus shape or lumps be the main manifestations of varicose veins of the lower extremity.The many superficial vein blood flow reflux caused due to superficial vein first pair of valvular insufficiency of the cause of disease, increase veins of lower extremity pressure and cause.Secondly, geneogenous wall of vein weakness is also major reason, and patient is often associated with the whole body or circumscribed wall of vein defect, when vein pressure increases, just produces tortuous, the expansion of vein.Finally, stand for a long time, fat and abdominal pressure etc. because of procatarxis can increase that vein pressure all can increase that varicosis development occurs may.

Varicosis morbidity is early stage, mostly is the lower limb swollen discomfort of acid and dull pain sense, has limbs sense of heaviness simultaneously, easily weak.How above-mentionedly behind station for a long time feel to increase the weight of, then can be alleviated by flat sleeping, limb lifting.Pathological changes middle and late stage, wall of vein is impaired, vein protuberance, expansion, tortuous, in Lumbricus sample outward appearance, with the traveling of medial leg great saphenous vein, district is obvious.Course of disease elder, limb skin then occurs that trophism changes, and as desquamation, pruritus, pigmentation etc., even forms eczema and ulcer.Along with the differentiation of the state of an illness, can with the symptom such as pain, lower extremity swelling and distension, stasis dermatitis, superficial vein thrombosis of blood vessel traveling.

Motherland's medical science thinks that varicosis belongs to the BI-syndrome involved the blood vessels category of the traditional Chinese medical science, is referred to as nodular varicosity, and merging eczema claims eczema, merging ulcer claims ecthyma.Now how weak owing to wall of vein, pressure rising etc. in vein valve defect and superficial vein.Varicose veins of the lower extremity is one of surgical common disease, and prevalence is very large in various countries' difference.The sickness rate of many American-European countries is up to 20%-40%, and in China, Zhang Peihua etc. investigate in more than 15 years old crowd, and sickness rate is 8.16%, and more than 45 years old is 16.4%, calculates existing patient about 8,000 ten thousand to 1 hundred million example.Varicose veins of the lower extremity is common with great saphenous vein, and independent varix of small saphenous vein is more rare, occurs the complication such as superficial thrombophlebitis, ulcer, variceal bleeding time serious.In the cause of disease, the traditional Chinese medical science think work and rest excessively, internal injury caused by excess of seven emotions, eating and drinking without temperance and cause healthy energy interior-deficiency, cause the stasis of blood because of void; Doctor trained in Western medicine think stand for a long time, heavy physical labour, habitual constipation, obesity etc. make valve lobe leaf bear pulling property of support pressure, with the passing of time thinning elongation and prolapsing, and cause valve insufficiency.The traditional Chinese medical science take void as primary disease basic reason, pathogenesis is summed up as the raw expectorant of the deficiency of vital energy, essential resistance of turbid phlegm, blood stagnancy due to deficiency of QI becomes the stasis of blood, stasis blocking venation, and different stages of development doublely can be shown in again the different pathogenesis change such as noxious dampness, damp and hot, cold-damp, and the side's of sending medication is carried out on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs basis, the traditional Chinese medical science has better motility and specific aim compared with the therapy such as simple doctor trained in Western medicine antiinflammatory, intravenous injection medicine, operation, and toxic and side effects is little, is applicable to prolonged application.But often there is the inapparent problem of curative effect in Chinese traditional treatment.Therefore, invention one effectively can treat varicosis, and toxic and side effects is little, and the Chinese medicine for external application being applicable to prolonged application has great importance.

Summary of the invention

Object of the present invention is exactly to solve problems of the prior art, in conjunction with the integrated Empirical formula of forefathers, according to doctor's row practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, according to research, inventor thinks that varicose veins of the lower extremity belongs to the traditional Chinese medical science " BI-syndrome involved the blood vessels ", categories such as " superficial obstructive phlebitis ", primary disease is because natural endowment is not enough, muscle arteries and veins is weak, in addition walking for a long time standing for a long time, overworked, further damage muscle arteries and veins, so that passages through which vital energy circulates does not conform to, QI-blood circulation is not smooth, blood stop up under, the expansion of congestion retardance venation is full, with the passing of time staggeredly tortuously to form, or deficiency of vital energy cold coagulation to cause the capable operation of gas not smooth, qi stagnation hemagglutination, stasis blocking blood vessels meridians, the stasis of blood is obstructed for a long time, ischemia ulceration infects, notably recurrent exerbation.Treatment according to state of an illness determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, should take the method for blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian.It is rapid-action in pharmaceutical preparation of the present invention, effect is strong, short treating period, easy to use, without obvious toxic-side effects, to varicosis determined curative effect.

For achieving the above object, the technical solution used in the present invention is as follows:

One is used for the treatment of cirsoid pharmaceutical composition, and it is prepared by following raw material and obtains:

Rhizoma Chuanxiong, the Radix Astragali, Cortex Phellodendri, Spina Gleditsiae, Radix Paeoniae Rubra, Retinervus Luffae Fructus, Folium Isatidis, Flos Carthami, Herba Epimedii, Fructus Ligustri Lucidi, Poria, Herba Taraxaci, Herba Houttuyniae, Cortex Magnoliae Officinalis, Radix Achyranthis Bidentatae, Radix Clematidis, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Flos Lonicerae, Ramulus Cinnamomi, Herba Hedyotidis Diffusae, Rhizoma Imperatae, Cortex Mori, Semen Ziziphi Spinosae, Semen Cuscutae, Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae.

Preferably, pharmaceutical composition of the present invention is prepared by the raw material of following weight proportioning and obtains:

Rhizoma Chuanxiong 35 parts, the Radix Astragali 35 parts, Cortex Phellodendri 35 parts, Spina Gleditsiae 35 parts, Radix Paeoniae Rubra 30 parts,

Retinervus Luffae Fructus 30 parts, Folium Isatidis 30 parts, 30 parts, Flos Carthami, Herba Epimedii 30 parts, Fructus Ligustri Lucidi 28 parts,

28 parts, Poria, Herba Taraxaci 28 parts, Herba Houttuyniae 25 parts, Cortex Magnoliae Officinalis 25 parts, Radix Achyranthis Bidentatae 25 parts,

Radix Clematidis 25 parts, Radix Aconiti Kusnezoffii 25 parts, Olibanum 20 parts, Myrrha 20 parts, Flos Lonicerae 20 parts,

Ramulus Cinnamomi 20 parts, Herba Hedyotidis Diffusae 15 parts, Rhizoma Imperatae 15 parts, Cortex Mori 15 parts, Semen Ziziphi Spinosae 10 parts,

Semen Cuscutae 10 parts, Radix Aconiti Lateralis Preparata 10 parts, 10 parts, Radix Glycyrrhizae.

The preparation method of described pharmaceutical composition is:

1) each raw material is taken, for subsequent use;

2) Rhizoma Chuanxiong, Spina Gleditsiae, Herba Epimedii, Poria, Herba Houttuyniae, Cortex Magnoliae Officinalis, Radix Clematidis, Herba Hedyotidis Diffusae, Rhizoma Imperatae, Cortex Mori, Semen Cuscutae, Radix Aconiti Lateralis Preparata mix homogeneously is got, add the ethanol relative to mixture 2-3 times weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste (80 DEG C) that density is 1.2g/ml;

3) get the water intense fire that residual components adds 5 times of weight to boil, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum (80 DEG C) that density is 1.2g/ml;

4) by step 1) and step 2) clear paste prepared merges, and stir, then preparation process makes different pharmaceutical preparation routinely.

Described pharmaceutical preparation is oral formulations or external preparation;

Preferably, the preparation method of external preparation is, adds the glycerol of sorbitol relative to clear paste weight 10% and 12%, is heated to 80 DEG C, prepares complex A;

Separately get and be heated to 80 DEG C relative to the stearic acid of clear paste weight 8%, the Yellow Vaselin of 3%, the lanoline of poly-Pyrusussuriensis fat 80,2% of 8% and the sucrose stearate of 1%, make melting, with complex A mixing and emulsifying 15 minutes, 80 DEG C are incubated 30 minutes, add the benzoic acid of 0.6% relative to clear paste weight and the ethyl hydroxybenzoate mixing of 0.15%, to obtain final product.

The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, and with low cost, it follows the prescriptions principle of the traditional Chinese medical science, reliably evident in efficacy to varicosis, mild in medicine property and, there is not toxic and side effects, have a extensive future.

Detailed description of the invention

Embodiment 1

One is used for the treatment of cirsoid pharmaceutical composition, and it is prepared by the raw material of following weight proportioning and obtains:

Rhizoma Chuanxiong 35 parts, the Radix Astragali 35 parts, Cortex Phellodendri 35 parts, Spina Gleditsiae 35 parts, Radix Paeoniae Rubra 30 parts,

Retinervus Luffae Fructus 30 parts, Folium Isatidis 30 parts, 30 parts, Flos Carthami, Herba Epimedii 30 parts, Fructus Ligustri Lucidi 28 parts,

28 parts, Poria, Herba Taraxaci 28 parts, Herba Houttuyniae 25 parts, Cortex Magnoliae Officinalis 25 parts, Radix Achyranthis Bidentatae 25 parts,

Radix Clematidis 25 parts, Radix Aconiti Kusnezoffii 25 parts, Olibanum 20 parts, Myrrha 20 parts, Flos Lonicerae 20 parts,

Ramulus Cinnamomi 20 parts, Herba Hedyotidis Diffusae 15 parts, Rhizoma Imperatae 15 parts, Cortex Mori 15 parts, Semen Ziziphi Spinosae 10 parts,

Semen Cuscutae 10 parts, Radix Aconiti Lateralis Preparata 10 parts, 10 parts, Radix Glycyrrhizae.

The preparation method of described pharmaceutical composition is:

1) each raw material is taken, for subsequent use;

2) Rhizoma Chuanxiong, Spina Gleditsiae, Herba Epimedii, Poria, Herba Houttuyniae, Cortex Magnoliae Officinalis, Radix Clematidis, Herba Hedyotidis Diffusae, Rhizoma Imperatae, Cortex Mori, Semen Cuscutae, Radix Aconiti Lateralis Preparata mix homogeneously is got, add the ethanol relative to mixture 2-3 times weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste (80 DEG C) that density is 1.2g/ml;

3) get the water intense fire that residual components adds 5 times of weight to boil, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum (80 DEG C) that density is 1.2g/ml;

4) by step 1) and step 2) clear paste prepared merges, and stir, then preparation process makes different pharmaceutical preparation routinely.

The preparation method of external preparation is, adds the glycerol of sorbitol relative to clear paste weight 10% and 12%, is heated to 80 DEG C, prepares complex A;

Separately get and be heated to 80 DEG C relative to the stearic acid of clear paste weight 8%, the Yellow Vaselin of 3%, the lanoline of poly-Pyrusussuriensis fat 80,2% of 8% and the sucrose stearate of 1%, make melting, with complex A mixing and emulsifying 15 minutes, 80 DEG C are incubated 30 minutes, add and mix relative to the benzoic acid of clear paste 0.6% and the ethyl hydroxybenzoate of 0.15%, obtain paste agent.

Embodiment 2

One is used for the treatment of cirsoid pharmaceutical composition, and it is prepared by the raw material of following weight proportioning and obtains:

Rhizoma Chuanxiong 35 parts, the Radix Astragali 35 parts, Cortex Phellodendri 35 parts, Spina Gleditsiae 35 parts, Radix Paeoniae Rubra 30 parts,

Retinervus Luffae Fructus 30 parts, Folium Isatidis 30 parts, 30 parts, Flos Carthami, Herba Epimedii 30 parts, Fructus Ligustri Lucidi 28 parts,

28 parts, Poria, Herba Taraxaci 28 parts, Herba Houttuyniae 25 parts, Cortex Magnoliae Officinalis 25 parts, Radix Achyranthis Bidentatae 25 parts,

Radix Clematidis 25 parts, Radix Aconiti Kusnezoffii 25 parts, Olibanum 20 parts, Myrrha 20 parts, Flos Lonicerae 20 parts,

Ramulus Cinnamomi 20 parts, Herba Hedyotidis Diffusae 15 parts, Rhizoma Imperatae 15 parts, Cortex Mori 15 parts, Semen Ziziphi Spinosae 10 parts,

Semen Cuscutae 10 parts, Radix Aconiti Lateralis Preparata 10 parts, 10 parts, Radix Glycyrrhizae.

The preparation method of described pharmaceutical composition is:

1) each raw material is taken, for subsequent use;

2) Rhizoma Chuanxiong, Spina Gleditsiae, Herba Epimedii, Poria, Herba Houttuyniae, Cortex Magnoliae Officinalis, Radix Clematidis, Herba Hedyotidis Diffusae, Rhizoma Imperatae, Cortex Mori, Semen Cuscutae, Radix Aconiti Lateralis Preparata mix homogeneously is got, add the ethanol relative to mixture 2-3 times weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste (80 DEG C) that density is 1.2g/ml;

3) get the water intense fire that residual components adds 5 times of weight to boil, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum (80 DEG C) that density is 1.2g/ml;

4) by step 1) and step 2) clear paste prepared merges, stirs, be split in by clear paste on non-woven fabrics and can prepare patch, and the area of non-woven fabrics is 15 be multiplied by 10cm; Sharing dosage is the every block non-woven fabrics of 10g/.

Embodiment 3

Irritation test

Acute toxicity test:

20 rabbit are divided into 2 groups at random, often organize 10, male and female half and half, with 10% sodium sulfide to family's rabbit back depilation, unhairing area is about 150cm ².The making of damaged skin adopts sterilization ferrum file to scratch (with oozing of blood degree of being), unguentum 1g prepared by the embodiment of the present invention 1 is applied respectively after unhairing, the patch sticking embodiment 2 preparation is also fixed with nonirritant adhesive plaster in depilation district, every animal sub-cage rearing, administration is after 24 hours 1, 24, 48, 72 is little of the 7th day, observe every day and record the body weight of animal, fur, gloss, diet, the change of eye and mucosa, respiratory center, nervous system, extremity activity and death condition, and put to death rabbit after Yu Qi, its heart of anatomic observation, liver, spleen, lung, the change of the internal organs such as kidney.

Result: the present invention prepares external preparation to the behavior of damaged skin rabbit, activity, diet, fur gloss, respiratory center, nervous system and body weight without any harmful effect, and none rabbit is dead.Rabbit is put to death, the main organs no abnormality seens such as its heart of anatomic observation, liver, spleen, lung, kidney after seven days.Therefore external preparation of the present invention does not all cause acute toxic reaction to rabbit on damaged skin.

Embodiment 3

Clinical data

The clinical patient collecting 116 routine varicose veins of the lower extremity altogether, is divided into 2 groups at random.Treatment group 58 example, man 34 example, female 24 example, age 27-51 year, course of disease 1-8; Matched group 58 example, man 32 example, female 26 example, age 26-50 year, course of disease 1.5-7.5.Two groups of Genders, ages compare with the course of disease, do not have significant difference, have comparability.

Diagnostic method

Two groups of patients all carry out the test of clinical great saphenous vein valvular function, color ultrasound examination, Deep venou Patency test and the test of communicating veins valvular function, all cases gets rid of congenital vascular malformation, deep vein thrombosis of lower extremity and Budd-Chairi syndrome etc. and primary deep venous valvular inadequacy patient.

Therapeutic Method

Treatment group: with cotton ball soaked in alcohol sterilization, remove the secretions on skin, uniform application liniment of the present invention (being prepared according to the method for embodiment 1), thickness is 1-2mm, covers one deck sliver, then covers sterile gauze, with adhesive plaster or the fixing wrapping of binder, prevent from coming off, change dressings every day 1 time.

Matched group vascular tablet for recovery, daily 3 times, each serving with 4.

All treat 1 month for two groups.

Statistical method, adopts SPSS18.0 statistics software data processing.

Therapeutic outcome

Efficacy evaluation method

Curative effect is divided into healing, part healing and recurrence 3 ranks: patient's naked eyes have no varicosis, fundamental symptoms disappears or is improved, without complication, target vein disappears for healing; The visible varicosis in a small amount of patient, fundamental symptoms disappear or improve, target vein segment is incompressible, segment section is inaccessible, caliber reduces reflux < 1s for part healing, patient's vein unchanged or comparatively treatment before situation increase the weight of, fundamental symptoms is unchanged or increase the weight of, and not closed through 2 months check target veins, caliber is unchanged, reflux >1s is recurrence.

Two groups of curative effects

After the treatment of month, two groups of therapeutic effect are as shown in table 1 below:

Table 1

Group	Number of cases	Cure	Part is cured	Recurrence	Total effective rate
						Treatment group	58	20	33	5	91.3%
Matched group	58	7	40	11	81%

Through statistical analysis, there is extremely significant difference in experimental group and matched group on clinical efficacy.

Embodiment 4

Model case

Thank certain, female, 48 years old, suffer from varicose veins of the lower extremity existing 3 years, both legs are just like " blue or green Serpentis " is wound around, and before treatment, the state of an illness is even more serious, little legs become numb when walking, send out heavy, distending pain, and having an injection, it is not remarkable to take medicine equal effect.Give patch prepared by embodiment 2, within 15 days, be a course for the treatment of, after two courses for the treatment of, clinical symptoms all disappears, and the state of an illness is fully recovered, and within 6 months, visits without bounce-back.

Zhang, 65, suffer from varicosis more than ten years, swelling is in recent years obvious, and skin color is dimmed purple gradually, and shank Zeng Yin occurs ulceration by after wound.Before treatment, main manifestations is left lower extremity swelling, and skin purple is black, and area is comparatively large, and the scleroma lump that feel is harder, Zu Xue district is mulberry, and diseased region skin temperature is higher than contralateral limbs.Patient's private prosecution is even has left lower extremity to generate heat, swell, and pain is not obvious.Give patch prepared by embodiment 2, within 15 days, be a course for the treatment of, after the treatment of 4 courses for the treatment of, lump dissipates substantially, and skin temperature is identical with offside, and Zu Xue district is dark violet also disappears the transference cures such as hot, swollen, pain substantially.Varicosis is cured, and clinical symptoms all disappears, and the state of an illness is fully recovered, and within 6 months, visits without bounce-back.

Above-mentioned each Chinese medicinal components that the present invention adopts makes compatibility mutually, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, through clinical verification, have good therapeutic effect to varicosis, in the applicant's medical practice for many years, the case Numerous of curing, all obtains good effect, and with low cost, alleviate the burden of patient, have broad application prospects.

Claims (4)

1. for a cirsoid externally applied liniment, it is characterized in that, described liniment is prepared by following raw material and obtains:

Rhizoma Chuanxiong, the Radix Astragali, Cortex Phellodendri, Spina Gleditsiae, Radix Paeoniae Rubra, Retinervus Luffae Fructus, Folium Isatidis, Flos Carthami, Herba Epimedii, Fructus Ligustri Lucidi, Poria, Herba Taraxaci, Herba Houttuyniae, Cortex Magnoliae Officinalis, Radix Achyranthis Bidentatae, Radix Clematidis, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Flos Lonicerae, Ramulus Cinnamomi, Herba Hedyotidis Diffusae, Rhizoma Imperatae, Cortex Mori, Semen Ziziphi Spinosae, Semen Cuscutae, Radix Aconiti Lateralis Preparata, Radix Glycyrrhizae.

2. liniment according to claim 1, is characterized in that, described liniment is prepared by the raw material of following weight parts and obtains:

Rhizoma Chuanxiong 35 parts, the Radix Astragali 35 parts, Cortex Phellodendri 35 parts, Spina Gleditsiae 35 parts, Radix Paeoniae Rubra 30 parts,

Retinervus Luffae Fructus 30 parts, Folium Isatidis 30 parts, 30 parts, Flos Carthami, Herba Epimedii 30 parts, Fructus Ligustri Lucidi 28 parts,

28 parts, Poria, Herba Taraxaci 28 parts, Herba Houttuyniae 25 parts, Cortex Magnoliae Officinalis 25 parts, Radix Achyranthis Bidentatae 25 parts,

Radix Clematidis 25 parts, Radix Aconiti Kusnezoffii 25 parts, Olibanum 20 parts, Myrrha 20 parts, Flos Lonicerae 20 parts,

Ramulus Cinnamomi 20 parts, Herba Hedyotidis Diffusae 15 parts, Rhizoma Imperatae 15 parts, Cortex Mori 15 parts, Semen Ziziphi Spinosae 10 parts,

Semen Cuscutae 10 parts, Radix Aconiti Lateralis Preparata 10 parts, 10 parts, Radix Glycyrrhizae.

3. the liniment according to claim 1-2, is characterized in that, the preparation method of described liniment comprises the steps:

1) each raw material is taken according to weight portion, for subsequent use;

2) Rhizoma Chuanxiong, Spina Gleditsiae, Herba Epimedii, Poria, Herba Houttuyniae, Cortex Magnoliae Officinalis, Radix Clematidis, Herba Hedyotidis Diffusae, Rhizoma Imperatae, Cortex Mori, Semen Cuscutae, Radix Aconiti Lateralis Preparata is got, mix homogeneously, add the ethanol relative to mixture 2-3 times weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml;

3) get surplus stock, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml;

4) by step 1) and step 2) clear paste prepared merges, stirs, be then prepared into liniment according to a conventional method.

4. liniment described in claim 1-3 is used for cirsoid purposes.