CN104758593A - Medicine composite for treating pregnancy hypertension - Google Patents
Medicine composite for treating pregnancy hypertension Download PDFInfo
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- CN104758593A CN104758593A CN201510210286.0A CN201510210286A CN104758593A CN 104758593 A CN104758593 A CN 104758593A CN 201510210286 A CN201510210286 A CN 201510210286A CN 104758593 A CN104758593 A CN 104758593A
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- hypertension syndrome
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Abstract
The invention discloses a medicine composite for treating pregnancy hypertension and belongs to the technical field of traditional Chinese medicines. The medicine composite for treating pregnancy hypertension is good in treatment effect, high in cure rate and free of side effects. The raw materials include radix ophiopogonis, poria cocos, unprocessed rehmannia roots, barbary wolfberry fruit, achyranthes, chrysanthemum, cassia seed, rhizoma coptidis and saposhnicovia divaricata. The medicine composite for treating pregnancy hypertension can eliminate the clinical symptoms of a patient soon, and meanwhile has the functions of nourishing the kidney and liver, strengthening the spleen, excreting dampness, invigorating spleen-stomach and replenishing qi, decreasing blood pressure, treating oedema, and eliminating proteinuria and other symptoms.
Description
Technical field
The invention belongs to technical field of Chinese medicine, relate to a kind of pharmaceutical composition for the treatment of pregnancy-hypertension syndrome and preparation method thereof.
Background technology
Pregnancy induced hypertension syndrome (hypertensive disorders in pregnancy) is called for short " pregnancy induced hypertension syndrome ", is a kind of commonly encountered diseases, after primary disease betides pregnant 20 weeks, and clinical manifestation mild PIH: hypertension, albuminuria, edema; Moderate PIH: hypertension, albuminuria, edema, no conscious sympton; Height pregnancy induced hypertension syndrome: preeclampsia; Have a convulsion time serious, go into a coma, cardiorenal function exhaustion even causes mother and baby dead.Primary disease is trimester of pregnancy distinctive disease, sickness rate about 10%, is the major reason of pregnant and lying-in women and perinatal feruses death.
Pregnancy induced hypertension syndrome, particularly severe PIH, pregnancy induced hypertension syndrome heart disease, placental abruption, pulmonary edema, coagulation disorders, cerebral hemorrhage, acute renal failure, HELLP syndrome (haemolysis, liver enzyme raise, the thrombocytopenia) complication such as postpartum hemorrhage and postpartum circulatory failure can be there is.These complication causes death.
The cause of disease of pregnancy induced hypertension syndrome is still not clear at present, and basic pathology is changed to whole body arteriolospasm, the Placenta Hominis blood supply insufficiency caused by uterine vascular spasm, depressed placental function.Can cause that fetal distress, fetal development are slow, stillborn fetus, stillbirth or neonatal death; Severe hypertensive pregnancies, should hospitalization immediately once making a definite diagnosis, and processes in time, the generation of prevention eclamposia and complication.The Therapeutic Principle of pregnancy induced hypertension syndrome is spasmolytic, blood pressure lowering, calmness, rationally dilatation, if desired diuresis, and magnesium sulfate be in, the spasmolytic medicine of severe PIH first-selection.
The traditional Chinese medical science think primary disease duty in the dirty functional disorder of liver,spleen,kidney three.Deficiency of spleen-YANG and kidneyYANG, water-damp not being transformed, general in flesh table; Or how depressed element is, functional activity of QI being not smooth, pregnant rear carcass is gradually long in addition, hinders ascending or descending movement of vital Qi, and the stagnation of QI is wet stops, and overflow in skin and send out as edema, this is edema during pregnancy.Visceral-qi deficiency in origin, under the cloudy blood of pregnant rear parent, fetus nourishing is appointed in poly-punching, and cloudy point must be lost, and the moon is YANG hyperactivity suppressing not, and liver-yang is partially high, above disturbs key clearly; Or after mid trimester of pregnancy, carcass is gradually large, affect ascending or descending movement of vital Qi, the stagnation of QI violates spleen, insufficiency of the spleenly wetly to gather, and turns to expectorant turbid, liver-yang hold under the arm expectorant turbid on disturb key clearly and then occur the vertigo, headache, blurring of vision, this is vertigo in pregnancy.If cloudy blood deficiency very, excessive rising of liver-YANG, liver-wind stirring up internally; Or folder phlegm-fire is disturbed, hoodwink key clearly, and have wind symptom, twitch and send out as eclamposia.
Summary of the invention
The object of this invention is to provide the pharmaceutical composition for the treatment of treatment pregnancy-hypertension syndrome that a kind of good effect, cure rate are high, have no side effect.
For achieving the above object, pharmaceutical composition of the present invention is made up of following raw material:
Radix Ophiopogonis, Poria, Radix Rehmanniae, Fructus Lycii, Radix Achyranthis Bidentatae, Flos Chrysanthemi, Semen Cassiae, Rhizoma Coptidis and Radix Saposhnikoviae.
Preferably, for achieving the above object, pharmaceutical composition of the present invention is made up of the raw material of following weight portion:
Radix Ophiopogonis 10-30, Poria 10-30, Radix Rehmanniae 5-20, Fructus Lycii 10-30, Radix Achyranthis Bidentatae 5-20, Flos Chrysanthemi 10-30, Semen Cassiae 10-30, Rhizoma Coptidis 2-12 and Radix Saposhnikoviae 5-15.
Specifically preferably, for achieving the above object, pharmaceutical composition of the present invention is made up of the raw material of following weight portion:
Radix Ophiopogonis 20, Poria 20, Radix Rehmanniae 18, Fructus Lycii 18, Radix Achyranthis Bidentatae 6, Flos Chrysanthemi 20, Semen Cassiae 18, Rhizoma Coptidis 4 and Radix Saposhnikoviae 6.
Fang Zhong: Radix Ophiopogonis, nature and flavor were sweet, micro-hardship, is slightly cold.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation.Poria nature and flavor are sweet, light, flat.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Radix Rehmanniae is sweet, cold.Clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.Fructus Lycii is sweet, flat.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Radix Achyranthis Bidentatae is bitter, sour, flat.Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.Flos Chrysanthemi nature and flavor are sweet, bitter, are slightly cold.Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.Semen Cassiae is sweet, bitter, salty, is slightly cold.Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Rhizoma Coptidis is bitter, cold.Heat clearing and damp drying, eliminating fire and detoxication.Radix Saposhnikoviae acrid, sweet, warm.Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.Through clinical verification, all taste medical materials of the present invention share can eliminate patient clinical symptom fast, simultaneously can the liver and kidney nourishing, spleen invigorating eliminating dampness by diuresis, invigorating the spleen and replenishing QI, play the effect of the symptoms such as blood pressure lowering, consumer edema, elimination albuminuria.
Another object of the present invention is to provide a kind of preparation method for the treatment of the pharmaceutical composition of pregnancy induced hypertension syndrome, particularly, comprises the following steps:
1) Radix Ophiopogonis, Radix Rehmanniae, Fructus Lycii, Flos Chrysanthemi and Semen Cassiae is taken, with 95%-98% alcohol reflux 2 times, each 1-2 hour, merge extractive liquid, reclaim ethanol, concentrated extracting solution, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.15-1.25 is for subsequent use;
2) by step 1) filtering residue add water, reflux, extract, 2 times, each 1-2 hour, filters, merging filtrate, concentrated extracting solution, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.15-1.25 is for subsequent use;
3) by recipe quantity, get Poria, Radix Achyranthis Bidentatae, Rhizoma Coptidis, Radix Saposhnikoviae mixing, be dried and crushed into fine powder, cross 100 mesh sieves.
4) by step 1) and step 2) mixing of gained concentrated solution, adding step 3) gained fine powder and pharmaceutically acceptable carrier be prepared into the dosage forms such as tablet, capsule, oral liquid, granule, drop pill.
The pharmaceutical composition that the present invention treats pregnancy induced hypertension syndrome has the following advantages:
1. Chinese medicine composition synergism of the present invention is strong, and taking dose is low, and safety is without any side effects, does not affect cardiac output, renal blood flow and placenta uterina groundwater increment, does not affect the normal development of fetus.
2. treat preeclampsia, evident in efficacy, effective percentage is high.
3. raw material sources are extensive, and preparation technology is simple.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
EXAMPLE l capsule
Prescription (weight portion):
Radix Ophiopogonis 30, Poria 30, Radix Rehmanniae 20, Fructus Lycii 30, Radix Achyranthis Bidentatae 15, Flos Chrysanthemi 30, Semen Cassiae 15, Rhizoma Coptidis 6 and Radix Saposhnikoviae 15.
Preparation method:
1) take Radix Ophiopogonis, Radix Rehmanniae, Fructus Lycii, Flos Chrysanthemi and Semen Cassiae, with 98% alcohol reflux 2 times, each 1 hour, merge extractive liquid, reclaimed ethanol, concentrated extracting solution, and be concentrated into 65 DEG C of relative densities be 1.20 concentrated solution for subsequent use;
2) by step 1) filtering residue add the water of 8 times of weight, reflux, extract, 2 times, each 1 hour, filter, merging filtrate, concentrated extracting solution, and be concentrated into 65 DEG C of relative densities be 1.20 concentrated solution for subsequent use;
3) by recipe quantity, get Poria, Radix Achyranthis Bidentatae, Rhizoma Coptidis, Radix Saposhnikoviae mixing, be dried and crushed into fine powder, cross 100 mesh sieves;
4) by step 1) and step 2) mixing of gained concentrated solution, add step 3) gained fine powder, mix homogeneously, dry, sterilizing, loads No. 0 Capsules, obtains capsule.Every containing crude drug 0.5g.
The preparation of embodiment 2 granule
Prescription (weight portion):
Radix Ophiopogonis 20, Poria 20, Radix Rehmanniae 18, Fructus Lycii 18, Radix Achyranthis Bidentatae 6, Flos Chrysanthemi 20, Semen Cassiae 18, Rhizoma Coptidis 4 and Radix Saposhnikoviae 6.
Preparation method:
1) take Radix Ophiopogonis, Radix Rehmanniae, Fructus Lycii, Flos Chrysanthemi and Semen Cassiae, with 95% alcohol reflux 2 times, each 1 hour, merge extractive liquid, reclaimed ethanol, concentrated extracting solution, and be concentrated into 65 DEG C of relative densities be 1.18 concentrated solution for subsequent use;
2) by step 1) filtering residue add the water of 8 times of weight, reflux, extract, 2 times, each 1 hour, filter, merging filtrate, concentrated extracting solution, and be concentrated into 65 DEG C of relative densities be 1.18 concentrated solution for subsequent use;
3) by recipe quantity, get Poria, Radix Achyranthis Bidentatae, Rhizoma Coptidis, Radix Saposhnikoviae mixing, be dried and crushed into fine powder, cross 100 mesh sieves.
4) by step 1) and step 2) mixing of gained concentrated solution, adding step 3) gained fine powder fully mixes, and adds suitable amount of sucrose and hydroxypropyl methylcellulose, granulates, and after dry, pack, obtains granule.Every bag of 10g, containing crude drug 2g.
The preparation of embodiment 3 tablet
Prescription:
Radix Ophiopogonis 15, Poria 10, Radix Rehmanniae 6, Fructus Lycii 12, Radix Achyranthis Bidentatae 6, Flos Chrysanthemi 12, Semen Cassiae 10, Rhizoma Coptidis 3 and Radix Saposhnikoviae 5.
Preparation method:
1) take Radix Ophiopogonis, Radix Rehmanniae, Fructus Lycii, Flos Chrysanthemi and Semen Cassiae, with 95% alcohol reflux 2 times, each 2 hours, merge extractive liquid, reclaimed ethanol, concentrated extracting solution, and be concentrated into 65 DEG C of relative densities be 1.15 concentrated solution for subsequent use;
2) by step 1) filtering residue add the water of 6 times of weight, reflux, extract, 2 times, each 1 hour, filter, merging filtrate, concentrated extracting solution, and be concentrated into 65 DEG C of relative densities be 1.15 concentrated solution for subsequent use;
3) by recipe quantity, get Poria, Radix Achyranthis Bidentatae, Rhizoma Coptidis, Radix Saposhnikoviae mixing, be dried and crushed into fine powder, cross 100 mesh sieves.
4) by step 1) and step 2) mixing of gained concentrated solution, add the adjuvants such as appropriate amount of starch, alcohol granulation, tabletting, obtain tablet.Every sheet is containing crude drug 0.5g.
Pharmaceutical composition toxicity test of the present invention
One, acute toxicity test
1, tested medicine: pharmaceutical composition of the present invention.
2, experimental animal: regular grade NIH mice 10, body weight 20g ± 5g, male and female half and half, female mice is all without pregnant.
3, to mouse stomach Chinese medicine of the present invention, when given low reaches 280g crude drug/kg dosage, after administration, mice appearance activity reduces, recover normal after 1h, Continuous Observation 7 days after administration, none dead mouse, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal.
4, result of the test shows: mouse stomach LD
50> 280g crude drug/kg.Point out pharmaceutical composition acute toxicity of the present invention extremely low, clinical drug safety.
Two, long term toxicity test
1, test objective:
Assess the drug safety of pharmaceutical composition of the present invention.
2, test material:
2.1 animals: select adult healthy SD rat 12, original body mass 210 ± 10g, male and female half and half, female rats is all without pregnant.
2.2 medicines: invention pharmaceutical composition of the present invention, adds purified water and be modulated into magma, for subsequent use.Per weight dosage is by about 100 times of calculating (clinical application amount foundation Pharmacopoeia of the People's Republic of China version in 2010) of clinical application amount, and dosage is 3g crude drug/kg/d.
3, test method
(1), experimental animal male and female sub-cage rearing, 5, every cage, quantitative feeding, freely drinks water.Experimental temperature, humidity are suitable.
(2), medication to the administration of SD rat oral gavage, every day 2 times, at every turn every 1.5g, successive administration 28 weeks.24h after administration in the 14th week, random execution 6, male and female half and half, observe and detect indices; All the other 6 are continued administration and observe to 28 weeks, and 24h after last 1 administration, puts to death all the other 6 rats, observe and detect indices.
4, result of the test
The all rats of daily observation all do not show any abnormal conditions; Hematological examination, blood parameters inspection, urinate biochemical, urine routine, system postmortem and histopathologic examination etc., indices is all normal.
Clinical laboratory data:
Chinese medicine composition of the present invention is in clinical sight patients with pregnancy induced hypertention 188 example in year February in May, 2011 to 2015, and clinical report is as follows:
1, physical data
In 188 routine patients, the oldest person 41 years old, reckling 26 years old, 32.5 years old mean age, wherein mild PIH 146 cases, moderate PIH patient 32 example, preeclampsia 10 example.
2, diagnostic criteria
Mild PIH: blood pressure >=140/90mmHg, < 150/100mmHg, or comparatively basic blood pressure raises 30/15mmHg, can accompany mild proteinuria (< 0.5g/24h) and (or) edema;
Moderate PIH: blood pressure >=150/100mmHg, < 160/110mmHg, albuminuria+(>=0.5g/24h) and (or) edema, no conscious sympton or have slight dizzy etc.;
Severe PIH (preeclampsia): blood pressure >=160/110mmHg, albuminuria ++ ~ ++++(>=5g/24h) and (or) edema, have headache, dim eyesight, the subjective symptoms such as uncomfortable in chest;
3, Therapeutic Method
Taking granule prepared by the embodiment of the present invention 2, every day two bags, getting up early and respectively take a bag before sleeping, 3 days was 1 course for the treatment of.Mild PIH patient takes 1-3 the course for the treatment of, and moderate PIH patient takes the 3-6 course for the treatment of, and preeclamptic patients takes 6-10 the course for the treatment of.
4, efficacy assessment standard
Cure: hypertension: high pressure returns to 130mmHg, low pressure returns to 85mmHg; Urine protein: protein negative in urine; Edema, tic, headache, dizziness, dim eyesight, uncomfortable in chest, blurred vision, the symptom of the hypertensive disorder in pregnancy that cardiopalmus tachypnea, eclamposia etc. are all disappears.
Effective: hypertension: high pressure returns to 140mmHg, low pressure returns to 90mmHg; Urine protein: albumen in urine+; Edema, tic, headache, dizziness, dim eyesight, uncomfortable in chest, blurred vision, the symptom of the hypertensive disorder in pregnancies such as cardiopalmus tachypnea, eclamposia alleviates.
Invalid: symptom does not alleviate, the state of an illness continues to worsen.
5, therapeutic outcome
Cure 162 examples, effective 25 examples, invalid 1 example, cure rate is 86.2%, and total effective rate is 99.4%.
In therapeutic process, all there is not obvious adverse reaction in 188 routine patients.Follow-up observation through the patient of Drug therapy of the present invention, none routine neonatal death.
Claims (6)
1. treat a pharmaceutical composition for pregnancy induced hypertension syndrome, it is characterized in that, be made up of following raw material:
Radix Ophiopogonis, Poria, Radix Rehmanniae, Fructus Lycii, Radix Achyranthis Bidentatae, Flos Chrysanthemi, Semen Cassiae, Rhizoma Coptidis and Radix Saposhnikoviae.
2. a kind of pharmaceutical composition for the treatment of pregnancy induced hypertension syndrome as claimed in claim 1, preferably, be made up of the raw material of following weight portion:
3. a kind of pharmaceutical composition for the treatment of pregnancy induced hypertension syndrome as claimed in claim 1, specifically preferably, be made up of the raw material of following weight portion:
4. a kind of pharmaceutical composition for the treatment of pregnancy induced hypertension syndrome according to claim 1,2,3, is characterized in that: described pharmaceutical composition is peroral dosage form.
5. treat a preparation method for the pharmaceutical composition of pregnancy induced hypertension syndrome, comprise the following steps:
1) Radix Ophiopogonis, Radix Rehmanniae, Fructus Lycii, Flos Chrysanthemi and Semen Cassiae is taken, with 95%-98% alcohol reflux 2 times, each 1-2 hour, merge extractive liquid, reclaim ethanol, concentrated extracting solution, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.15-1.25 is for subsequent use;
2) by step 1) filtering residue add water, reflux, extract, 2 times, each 1-2 hour, filters, merging filtrate, concentrated extracting solution, and to be concentrated into 65 DEG C of relative densities be that the concentrated solution of 1.15-1.25 is for subsequent use;
3) by recipe quantity, get Poria, Radix Achyranthis Bidentatae, Rhizoma Coptidis, Radix Saposhnikoviae mixing, be dried and crushed into fine powder, cross 100 mesh sieves;
4) by step 1) and step 2) mixing of gained concentrated solution, adding step 3) gained fine powder and pharmaceutically acceptable carrier be prepared into peroral dosage form.
6. a kind of pharmaceutical composition for the treatment of pregnancy induced hypertension syndrome according to claim 3,4, is characterized in that: described peroral dosage form is the dosage forms such as tablet, capsule, oral liquid, granule or drop pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510210286.0A CN104758593B (en) | 2015-04-28 | 2015-04-28 | A kind of pharmaceutical composition for treating pregnancy-induced hypertension |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510210286.0A CN104758593B (en) | 2015-04-28 | 2015-04-28 | A kind of pharmaceutical composition for treating pregnancy-induced hypertension |
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| Publication Number | Publication Date |
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| CN104758593A true CN104758593A (en) | 2015-07-08 |
| CN104758593B CN104758593B (en) | 2018-10-02 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7575765B1 (en) * | 2007-12-14 | 2009-08-18 | Whup-A-Bug, Inc. | Topical insect repellent |
| CN104173731A (en) * | 2014-09-02 | 2014-12-03 | 孔令英 | Formula of traditional Chinese medicine for treating hypertension due to deficiency of liver-yin and kidney-yin |
| CN104225204A (en) * | 2013-06-18 | 2014-12-24 | 郑建龙 | Health product prepared from lycium barbarum, chrysanthemum, Chinese yam and radix ophiopogonis |
-
2015
- 2015-04-28 CN CN201510210286.0A patent/CN104758593B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7575765B1 (en) * | 2007-12-14 | 2009-08-18 | Whup-A-Bug, Inc. | Topical insect repellent |
| CN104225204A (en) * | 2013-06-18 | 2014-12-24 | 郑建龙 | Health product prepared from lycium barbarum, chrysanthemum, Chinese yam and radix ophiopogonis |
| CN104173731A (en) * | 2014-09-02 | 2014-12-03 | 孔令英 | Formula of traditional Chinese medicine for treating hypertension due to deficiency of liver-yin and kidney-yin |
Non-Patent Citations (1)
| Title |
|---|
| 武强等: "《专家讲解高血压之药膳食疗—健康饮食 健康血压》", 30 September 2011, 第四军医大学出版社 * |
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Inventor after: Zheng Ling Inventor after: Song Fen Inventor after: Yang Haixia Inventor after: Tang Guoping Inventor before: The inventor has waived the right to be mentioned |
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Effective date of registration: 20180824 Address after: 266500 West Coast New District Hospital of traditional Chinese medicine, Qingdao, Shandong (No. 158 Hainan Island Road) Applicant after: Zheng Ling Address before: 276017 No. 5, Hou Jiao Qiu village, Fu Zhuang Office, Luozhuang District, Linyi, Shandong Applicant before: Tang Guoping |
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