CN104758008A - Biological tissue puncture device and biological tissue puncture method - Google Patents
Biological tissue puncture device and biological tissue puncture method Download PDFInfo
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- CN104758008A CN104758008A CN201410002972.4A CN201410002972A CN104758008A CN 104758008 A CN104758008 A CN 104758008A CN 201410002972 A CN201410002972 A CN 201410002972A CN 104758008 A CN104758008 A CN 104758008A
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Abstract
The invention provides a biological tissue puncture device and a biological tissue puncture method. The biological tissue puncture device comprises a first tube body and a second tube body, wherein the first tube body comprises an injection tube, a piston and a first syringe needle; the injection tube is filled with a medicine; the second tube body comprises an extracting end, a sampling tube and a second syringe needle; and the second syringe needle is a dual-head syringe needle and comprises a capture end and a collection end. The collection end, in the extraction end, of the second syringe needle punctures and runs through the interior of the sterile and negative-pressure sampling tube, and the sampling tube captures a specimen of a sampled tissue in a differential pressure manner through the capture end of the second syringe needle. The medicine in the injection tube can be injected before the first syringe needle and the second syringe needle puncture the surface of the sampled tissue and after the first syringe needle and the second syringe needle are extracted out of the sampled tissue but before leaving the body surface, so that the risks of diffusive infection and even metastasis of pathological cells are avoided.
Description
Technical field
The present invention relates to a kind of biological tissue sting device, espespecially a kind of sharp double-needle tube coordinates the mode of double needle, carry out gathering a corpse or other object for laboratory examination and chemical testing with a wherein syringe needle in body while, another syringe needle and can be extracted out after sampled tissue before puncturing into sampled tissue surface and continue to carry out the injection of a medicament before departing from body surface, makes a corpse or other object for laboratory examination and chemical testing further other normal structures of diffusive infection in body that the syringe needle of a sampling corpse or other object for laboratory examination and chemical testing can not will carry disease germs in the process pulling out body surface.
Background technology
Current medically must have pathological tissue or cytolgical examination for the determination diagnosis of tumor or cancer, operative treatment is not suitable for judge that the current situation degree of patient is suitable, and before execution chemotherapy or computer cutter, all must accept fine needle aspiration and obtain pathology corpse or other object for laboratory examination and chemical testing tissue, carry out the analysis of bacterial culture of histopathologic slide or a pathology corpse or other object for laboratory examination and chemical testing further, and the mode guiding fine needle aspiration is generally with under Abdominal echo, if but tumor is detected not easily under ultrasound, then guide fine needle aspiration with computerized axial tomography.
Carry out the good pernicious more difficult compared with section of interpretation tumor with fine needle aspirate cytology, whether be suitable for using the method for fine needle aspirate cytology inspection to come for diagnosing patient so the experience of general Pathology Doctors ' determines.When ultrasound finds that there is suspicious lump, need to arrange fine needle aspiration tumor cell to carry out cytolgical examination further again, to differentiate optimum and malignant tumor.At present, through the cytolgical examination of fine needle aspiration be Diagnosis of Thyroid Carcinoma the most effectively and the most accurately inspection method.General diplomatic report uses fine needle aspirate cytology to check tumor, and it judges that good pernicious sensitivity is about 80% and specificity is 100%.Its shortcoming to distinguish cancer in situ or Invasive carcinoma, so the use of fine needle aspirate cytology inspection is at present applied in the aspect such as screening patient or detecting metastatic lesion mostly.
But, at present with the collection corpse or other object for laboratory examination and chemical testing operating type of fine needle aspiration cancer tumor cells, only rest in general fine needle the large principle continuing to keep negative pressure, to enter in sampled tissue with Direct perforantes and extract fine needle immediately after its corpse or other object for laboratory examination and chemical testing of acquisition rapidly, but gather in the process of a corpse or other object for laboratory examination and chemical testing all without any extra safeguard procedures and device at this, during to stop further to extract this fine needle cause the corpse or other object for laboratory examination and chemical testing Release and dispersion of sampled tissue to normal surrounding tissue, cause sampledly organizing the normal structure of periphery to have to suffer virus contamination and the probability that expands that it infects scope, the risk of further increase cancer pathogenic bacteria transfer.
For liver tumor (hepatocarcinoma), in order to detailed diagnostics liver tumor often obtains the pathological tissue of tumor cell of liver in the mode of liver puncture, and after diagnosing establishment further, do correct treatment, but, the mode of puncture also likely makes cancerous cell via the path direction and shifting of passing through of puncture, though probability is not high, to have also be the probability of the generation with certain degree.In view of this, the present invention with a kind of biological tissue sting device be reduced to the process of the corpse or other object for laboratory examination and chemical testing sample extracting sampled tissue cause the infection risk of surrounding normal tissue, and then provide the selection of medical circles' another kind of low-risk puncture sampling corpse or other object for laboratory examination and chemical testing.
Summary of the invention
Main purpose of the present invention is to provide a kind of biological tissue sting device and method, double-needle tube is utilized to coordinate the mode of double needle, carry out gathering a corpse or other object for laboratory examination and chemical testing with a needle tubing in body while, another needle tubing and can be extracted out after sampled tissue before puncturing into sampled tissue and carry out the injection of a medicament before departing from body surface, reaches the object of normal surrounding tissue of protecting from infection in the corpse or other object for laboratory examination and chemical testing process of the sampled tissue of acquisition further.
For achieving the above object, the technical solution used in the present invention is:
A kind of biological tissue sting device, it is characterized in that, it comprises:
One first body, comprising: a syringe, a piston and one first syringe needle; And
One second body, comprising: a probe tube and one second syringe needle;
Wherein, a medicament can be filled in this syringe, and this probe tube is used to provide the corpse or other object for laboratory examination and chemical testing collected this second syringe needle and capture.
Wherein, this first syringe needle and this second syringe needle are and pricking with needle.
Wherein, this second syringe needle is double needle kenel, and it comprises: acquisition end and a collecting terminal.
Wherein, this second body also comprises an extraction end; This probe tube is a freestanding bodies, and it includes: a lid and an accommodation space; Wherein, this probe tube is incorporated in this extraction end of this second body, and this collecting terminal of this second syringe needle is punctured this lid and running through in this accommodation space.
Wherein, this lid is that the soft rubber material with high adaptation formed, and is covered in this probe tube to make in this accommodation space and forms negative pressure state.
Wherein, this first body and this second body are integrally formed.
Wherein, this medicament be can kill the killing cancer cell medicament of cancerous cell or inhibition of cancer cell agent one of them.
Wherein, an outer surface of this first syringe needle have a plurality of side openings of an inside pipe wall of this first syringe needle through, to provide injection this medicament.
Wherein, this first syringe needle is concentric pin with this second syringe needle, and this second syringe needle to be positioned within this first syringe needle and to be positioned on same central shaft, and inside pipe wall interval one predeterminable range of an outer surface of this second syringe needle and this first syringe needle is to provide this drug injection.
For achieving the above object, the technical solution used in the present invention is:
A using method for biological tissue's sting device, it comprises following implementation step:
(A) provide biological tissue's sting device, it comprises: one first body and one second body, and this first body comprises: a syringe, a piston and one first syringe needle; This second body comprises: a probe tube and one second syringe needle; Wherein, in this syringe, a medicament is filled with;
(B) this first syringe needle of this first body and this second syringe needle of this second body are inserted in a body surface simultaneously;
(C) make this first syringe needle and this second syringe needle move closer to while a sampled tissue surface, this piston pushing this first syringe needle makes this medicament in this syringe inject in advance;
(D) will at least the puncture of this second syringe needle enter in sampled tissue, and now this first syringe needle stops this medicament of injection;
(E) this probe tube being incorporated into one of this second body extracts in end, the lid that the collecting terminal being positioned at this extraction end by means of this second syringe needle punctures on this probe tube, and run through in the accommodation space in negative pressure in this probe tube, and a sick cell corpse or other object for laboratory examination and chemical testing for this sampled tissue of acquisition is held to enter in this accommodation space of this probe tube by the mode of pressure differential via an acquisition of this second syringe needle;
(F) when will at least this second syringe needle pulls out this sampled tissue surface time, make this medicament of continuous injection in this syringe, until this first syringe needle and this second syringe needle are pulled out body surface outer after stop this medicament to stop injecting immediately; And
(G) this probe tube of a sick cell corpse or other object for laboratory examination and chemical testing for this sampled tissue there is is to take out by this extraction end of this second body acquisition.
This collecting terminal puncture being positioned at this extraction end by means of this second syringe needle runs through and has Sterile vacuum and this probe tube of negative pressure, is captured a corpse or other object for laboratory examination and chemical testing for sampled tissue by this probe tube in the mode of pressure differential via this acquisition end of this second syringe needle.Medicament in this syringe and can be extracted out before this first syringe needle and the second syringe needle puncture into sampled tissue after sampled tissue and to inject before departing from body surface, so reaches and avoids proliferation of germs to infect the risk even shifted.
Accompanying drawing explanation
The generalized section of Tu1Shi biological tissue of the present invention sting device first preferred embodiment;
The enforcement view of Tu2Shi biological tissue of the present invention sting device first preferred embodiment;
The flow chart of steps of Tu3Shi biological tissue of the present invention sting device first preferred embodiment using method;
The enlarged schematic partial view of Tu4Shi biological tissue of the present invention sting device second preferred embodiment;
The partial cutaway schematic view of Tu5Shi biological tissue of the present invention sting device the 3rd preferred embodiment;
The generalized section of Tu6Shi biological tissue of the present invention sting device the 3rd preferred embodiment.
Description of reference numerals: 1,1a ~ biological tissue's sting device; 11,11a ~ the first body; 111,111a ~ syringe; 112,112a ~ piston; 1121a ~ middle vacancy; 1122a ~ piston head; 113,113a ~ the first syringe needle; 1131 ~ outer surface; 1132,1132a ~ inside pipe wall; 1133,1133a ~ side opening; 12,12a ~ the second body; ; 121 ~ extract end; 122,122a ~ probe tube; ; 1221 ~ lid; ; 1222,1222a ~ accommodation space; 1223a ~ cock body; 123,123a ~ the second syringe needle; 1231,1231a ~ acquisition end; 1232 ~ collecting terminal; 1233a ~ outer surface; 3 ~ medicament; 5 ~ central shaft; 8 ~ culture fluid; 91 ~ sampled tissue; 92 ~ body surface; 93 ~ normal structure; 94 ~ corpse or other object for laboratory examination and chemical testing; 95 ~ region.
Detailed description of the invention
Refer to shown in Fig. 1 and Fig. 2, Fig. 1 and Fig. 2 is respectively the generalized section of biological tissue of the present invention sting device first preferred embodiment and implements view.In the present invention first preferred embodiment, this biological tissue's sting device 1 comprises: one first body 11 and one second body 12.This first body 11 also comprises: syringe 111, piston 112 and one first syringe needle 113.This second body 12 also comprises: one extracts end 121, probe tube 122 and one second syringe needle 123.This first syringe needle 113 is connected with in this syringe 111, and in addition, this second syringe needle 123 is double needle kenels, and it comprises acquisition end 1231 and a collecting terminal 1232; Wherein, this collecting terminal 1232 is positioned within this extraction end 121, and gathers corpse or other object for laboratory examination and chemical testing sample by this acquisition end 1231.A medicament 3 can be filled in this syringe 111, and this medicament 3 can be specially for can kill cancerous cell but relatively can not injure the current existing existing killing cancer cell medicament of general human tissue cell or inhibition of cancer cell agent one of them.In the present embodiment, this first syringe needle 113 with this second syringe needle 123 is and pricking with needle, and the syringe 111 of this first body 11 is integrally formed with the extraction end 121 of this second body 12.
This probe tube 122 of this second body 12 is independently bodys, and it includes: lid 1221 and an accommodation space 1222.This lid 1221 is that the soft rubber material with high adaptation formed, and is covered in this probe tube 122 to make in this accommodation space 1222 and forms Sterile vacuum and negative pressure state.This probe tube 122 can stretch into and be incorporated in this extraction end 121 of this second body 12, can to puncture this lid 1221 through by means of this collecting terminal 1232 of this second syringe needle 123 being positioned at this extraction end 121 after imposing certain pressure, make this collecting terminal 1232 enter in this accommodation space 1222 of this probe tube 122, capture one in the mode of pressure differential via this acquisition end 1231 of this second syringe needle 123 by this probe tube 122 and sampledly organize 91(tumor or cancer cell population or sick cell group) a corpse or other object for laboratory examination and chemical testing.This medicament 3 in this syringe 111 can puncture into body surface 92(such as internal organs top layer or human body skin top layer in this first syringe needle 113 and the second syringe needle 123) but during puncturing into before this sampled tissue 91 surface, and to extract out behind this sampled tissue 91 surface and to depart from body surface 92(internal organs top layer or skin surface) front during, continue to inject, therefore can on body surface 92(such as internal organs top layer or human body skin top layer) form with sampled tissue 91 surface the region that an injection has this medicament 3 between the two, so reach and avoid organizing the sick cell of a corpse or other object for laboratory examination and chemical testing 94 (such as cancerous cell) or the sick cell of this sampled tissue 91 because this acquisition end 1231 of the second syringe needle 123 is infected with because of sampled, or the wound caused leaks sick cell diffusive infection to surrounding normal tissue 93 because sampling is punctured, and have the risk causing cancer cell metastasis to other organs.
In other words, in biological tissue of the present invention sting device first preferred embodiment, this first syringe needle 113 next-door neighbour of this first body 11 is against this second syringe needle 123 1 side of this second body 12, in time capturing the corpse or other object for laboratory examination and chemical testing operation in this sampled tissue 91, this first syringe needle 113 and this second syringe needle 123 puncture within this body surface 92 simultaneously, and before arriving this sampled tissue 91 surface after passing through this normal structure 93 (not yet puncture enters sampled tissue), push this piston 112 of this first body 11 in advance in right amount so that this medicament 3 of filling in this syringe 111 is carried out protection injection by this first syringe needle 113, with this acquisition end 1231 reducing this second syringe needle 123 in puncture this sampled tissue 91 time the sick cell Release and dispersion that causes to peripheral normal structure 93, or extracting the probability in the process detaching the second syringe needle 123, the sick cell that this acquisition of second syringe needle 123 holds 1231 outer surfaces to be infected with being diffused to peripheral normal structure 93, and relatively can not jeopardize Normocellular existence because the attribute of this medicament 3 only carries out slaughtering protection for sick cell or cancerous cell and antibacterial, therefore significantly can reduce this first syringe needle 113 punctures into when this sampled tissue 91 samples a corpse or other object for laboratory examination and chemical testing with this second syringe needle 123, this the sampled 91(of organizing tumor may be caused) born of the same parents of interior pathological changes or cancerous cell leak the risk infecting and cause to this normal structure 93 peripheral because puncture causes.
When waiting for that this first syringe needle 113 and this second syringe needle 123 enter in this sampled tissue 91, namely this medicament 3 in this syringe 111 stops injection and carries out this with this acquisition end 1231 of this second syringe needle 123 sampledly organizing 91(tumor then) Collecting operation of interior sick cell, namely utilize the mode of pressure differential to draw this sampled 91(of organizing tumor via this probe tube 122) in sick cell and undertaken capturing the sick cell tissue in this sampled tissue 91 by this acquisition end 1231 of this second syringe needle 123, and puncture into this lid 1221 by this collecting terminal 1232 and this accommodation space 1222 entered in this probe tube 122 carries out the sampled of a predetermined number organizes corpse or other object for laboratory examination and chemical testing 94(cancerous cell or sick cell) collection action.
And then, when this first syringe needle 113 and this second syringe needle 123 pull out this sampled tissue 91 surface, push this piston 112 and make this medicament 3 of continuous injection in this syringe 111, until by this first syringe needle 113 and this second syringe needle 123 by the path of former puncture detach return this body surface 92 outer after, stopping pushing this piston 112 immediately makes this medicament 3 in this syringe 111 stop injection, and have sampled this probe tube 122 of a corpse or other object for laboratory examination and chemical testing 94 of organizing to take out by this extraction end 121 of this second body 12 by gathering, this collecting terminal 1232 of this second syringe needle 123 is made to pull out within this probe tube 122.
Thus, not only complete this sampled corpse or other object for laboratory examination and chemical testing Collecting operation organizing a corpse or other object for laboratory examination and chemical testing 94, more relying on biological tissue of the present invention sting device 1 to reach avoids this sampled tissue 91 after sampling, makes the sick cell (cancerous cell) in this sampled tissue 91 be even transferred to the risk of other organs to surrounding normal tissue 93 by this sampled tissue 91 diffusive infection in this first syringe needle 113 and the path of passing through of the second syringe needle 123 before extracting body surface 92.
Referring to shown in Fig. 3, is the flow chart of steps of biological tissue of the present invention sting device first preferred embodiment using method.The using method of biological tissue of the present invention sting device, wherein, includes the following step in time implementing:
(A) medicament of preset dose will be filled in a syringe of one first body of this biological tissue's sting device;
(B) one first syringe needle of this first body and one second syringe needle of one second body are inserted in body surface simultaneously;
(C) when before this first syringe needle and this second syringe needle are close to a sampled tissue surface, the piston pushing this first syringe needle makes this medicament in this syringe inject in advance;
(D) when this first syringe needle and this second syringe needle puncture enter in sampled tissue time, this first syringe needle stops injecting this medicament immediately;
(E) probe tube being incorporated into one of this second body extracts in end, the lid that the collecting terminal being positioned at this extraction end by means of this second syringe needle punctures on this probe tube, and run through in this probe tube and there is Sterile vacuum and in an accommodation space of vacuum effect, and by the mode of the pressure differential sick cell corpse or other object for laboratory examination and chemical testing via this sampled tissue of acquisition end acquisition of this second syringe needle;
(F) when this first syringe needle and this second syringe needle pull out this sampled tissue surface, push this piston and make this medicament of continuous injection in this syringe, make this medicament in this syringe stop injecting until stop pushing this piston immediately when this first syringe needle and this second syringe needle being pulled out body surface outer; And
(G) there is this probe tube of a sick cell corpse or other object for laboratory examination and chemical testing for this sampled tissue to take out by this extraction end of this second body acquisition, make this collecting terminal of this second syringe needle detach this lid of this probe tube.
In other preferred embodiments of the present invention of the following stated, because the element of major part is the same as or similar to previous embodiment, therefore will repeat no more below identical element and structure, and identical element will directly give identical title and numbering, and then give same names for similar element but former numbering separately increase afterwards an English alphabet as a means of difference and it will not go into details, close first chat bright.
Referring to shown in Fig. 4, is the enlarged schematic partial view of biological tissue of the present invention sting device second preferred embodiment.The difference of biological tissue's sting device of the second preferred embodiment of the present invention and the first preferred embodiment described in Fig. 1, Fig. 2 is, an outer surface 1131 of this first syringe needle 113 is provided with a plurality of side openings 1133 of an inside pipe wall 1132 of this first syringe needle 113 through to provide injection this medicament 3.That is, can strengthen by a plurality of side openings 1133 set on this first syringe needle 113 space that sick cell diffusion is contained in protection further in time injecting this medicament 3, more can ensure the probability of the sick cell Release and dispersion that this acquisition end 1231 reducing this second syringe needle 123 causes in time capturing a corpse or other object for laboratory examination and chemical testing for this sampled tissue 91.
Refer to shown in Fig. 5, Fig. 6, be respectively partial cutaway schematic view and the generalized section of biological tissue of the present invention sting device the 3rd preferred embodiment.The difference of biological tissue's sting device of the 3rd preferred embodiment of the present invention and the second preferred embodiment described in Fig. 4 is, this biological tissue sting device 1a of the 3rd preferred embodiment of the present invention, wherein, this first syringe needle 113a is concentric pin with this second syringe needle 123a, and the pin hole central point of this first syringe needle 113a and this second syringe needle 123a is positioned on same central shaft 5, and this second syringe needle 123a is positioned within this first syringe needle 113a and forms the structure that a pin has pin (the first syringe needle 113a inside is also equipped with the second syringe needle 123a).And this inside pipe wall 1132a interval one predeterminable range d of the outer surface 1233a of this second syringe needle 123a and this first syringe needle 113a can go out from the gap injected current between the first syringe needle 113a inner surface and the second syringe needle 123a outer surface to provide this medicament 3.In addition, in this biological tissue of the present invention sting device 1a in time gathering a corpse or other object for laboratory examination and chemical testing, this acquisition end 1231a of this second syringe needle 123a is extended to be entered in the outer of this first syringe needle 113a and sampledly organizes the collection action carrying out cancerous cell or sick cell within a corpse or other object for laboratory examination and chemical testing 94 in this.
Furtherly, this biological tissue sting device 1a of the 3rd preferred embodiment of the present invention, wherein, this second body 12a can stretch into the vacancy 1121a being arranged in this piston 112a central authorities, and is arranged in the lump within this first body 11a with this piston 112a.The probe tube 122a of this second body 12a is an independently body, and it includes: a lid 1221a, an accommodation space 1222a and a cock body 1223a.This lid 1221a is that the soft rubber material with high adaptation formed, and is covered in this probe tube 122a to make in this accommodation space 1222a and forms aseptic and negative pressure state.Further, in the present embodiment, an appropriate existing culture fluid 8 for preserving gathered sick cell can in this probe tube 122a of this second body 12a, be pre-charged with.Because this piston 112a is one end through (for inserting probe tube 122a) and relatively the other end is the hollow tube of a soft piston head 1122a kenel, can make this probe tube 122a of this second body 12a and this second syringe needle 123a of connecting be inserted into this piston 112a this within the 1121a of vacancy.
When carrying out corpse or other object for laboratory examination and chemical testing sampling action, first terminal spine before the one first syringe needle 113a of this first body 11a is inserted in body surface 92.When this first syringe needle 113a moves closer in this sampled tissue 91 but during not yet arriving sampled tissue 91 surface, this piston 112a pushing this first syringe needle 113a makes this medicament 3 in this syringe 111a inject in advance, can therefore on body surface 92(such as internal organs top layer or human body skin top layer) form with sampled tissue 91 surface the region 95 that an injection has this medicament 3 between the two.Until when the front end of the first syringe needle 113a arrives or is about to arrive sampled tissue 91 surface, and then, this acquisition end 1231a pushing this second syringe needle 123a front end that this probe tube 122a connects by this second body 12a protrudes out via the inside of the first syringe needle 113a, and simultaneously by this medicament 3 in this first syringe needle 113a by a plurality of side opening 1133a set on this first syringe needle 113a by this medicament 3 in this first syringe needle 113a being extruded by those side openings 1133a in the extrusion process of this second syringe needle 123a, further this acquisition end 1231a of this second syringe needle 123a is stretched out in outside this first syringe needle 113a, and puncture to enter in sampled tissue 91 (but now the first syringe needle 113a front end still rest on sampled tissue 91 outer surface can not thrust).Tail end (namely collecting terminal) by means of this second syringe needle 123a punctures through this lid 1221a and protrude in this accommodation space 1222a of this probe tube 122a, by the negative pressure state of this probe tube 122a inside, draw via this acquisition end 1231a of this second syringe needle 123a in the mode of pressure differential, capture the sampled 91(of an organizing tumor or cancer cell population or sick cell group) a sick cell corpse or other object for laboratory examination and chemical testing enter probe tube 122a inside accommodation space 1222a in and be soaked in culture fluid 8, reached the action that a corpse or other object for laboratory examination and chemical testing collects cancerous cell or sick cell.Then, by acquisition have this probe tube 122a of a corpse or other object for laboratory examination and chemical testing for this sampled tissue 91 pull out this piston 112a this in vacancy 1121a, then, the piston 112a that chooses in appropriate amount makes the second syringe needle 123a be chosen together with piston 112a, until the acquisition end 1231a of the second syringe needle 123a retracts once again, the first syringe needle 113a front end is inner, afterwards, again this first body 11a and this first syringe needle 113a is detached gradually the surface of sampled tissue 91, now can optionally again by this medicament 3 in this first syringe needle 113a by marginally extruding in those side openings 1133a (guaranteeing the killing cancer cell effect in the region 95 of this medicament 3), until the first syringe needle 113a is detached outside body surface 92 completely.Certainly, in the first body 11a and this first syringe needle 113a is being detached the surface of sampled tissue 91 gradually but is not yet leaving in the process outside body surface 92 described in the present embodiment, in fact also can not need again to inject this medicament 3, because in the present embodiment, now the acquisition end 1231a of this second syringe needle 123a is recessed in completely in the first syringe needle 113a and is soaked in the first syringe needle 113a in the original medicament 3 of institute, so do not have the misgivings sick cell that the acquisition end 1231a outer surface of the second syringe needle 123a is infected with being diffused into other positions.
Furtherly, this biological tissue sting device 1a of the 3rd preferred embodiment of the present invention includes the following step in time implementing:
(1) medicament of preset dose will be filled in a syringe of one first body of this biological tissue's sting device the 3rd preferred embodiment, and in a probe tube of one second body, fill a culture fluid of preset dose;
(2) this second body stretches within a vacancy of the piston being arranged in this first body, and is inserted in body surface by one first syringe needle of this first body;
(3) when before this first syringe needle is close to a sampled tissue surface, this piston pushing this first syringe needle makes this medicament in this syringe inject in advance, therefore can form at body surface (such as internal organs top layer or human body skin top layer) and sampled tissue surface the region that an injection has this medicament between the two;
(4) this acquisition end pushing this second needle tip that this probe tube connects by this second body protrudes out via the inside of the first syringe needle, and simultaneously by this medicament in this first syringe needle by a plurality of side openings set on this first syringe needle by this medicament in this first syringe needle being extruded by those side openings in the extrusion process of this second syringe needle;
(5) stretched out in outside this first syringe needle by this acquisition end of this second syringe needle, and puncture enters in sampled tissue, now the first needle tip still rests on sampled outer surface of organizing and can not thrust;
(6) to puncture this lid through and protrude in this accommodation space of this probe tube by means of the tail end (namely collecting terminal) of this second syringe needle a, by the negative pressure state in this probe tube portion, be soaked in culture fluid in the accommodation space that the sick cell corpse or other object for laboratory examination and chemical testing drawing, capture a sampled tissue (tumor or cancer cell population or sick cell group) enters probe tube inside in the mode of pressure differential via this acquisition end of this second syringe needle; And
(7) by acquisition have this probe tube of a corpse or other object for laboratory examination and chemical testing for this sampled tissue pull out this piston this in vacancy, then, piston of choosing in appropriate amount makes the second syringe needle be chosen together with piston, until the acquisition end of the second syringe needle is retracted once again, the first needle tip is inner, afterwards, then by this first body and this first syringe needle detach outside body surface.
In sum, a kind of biological tissue of the present invention sting device 1 comprises: one first body 11 and one second body 12.This first body 11 comprises: syringe 111, piston 112 and one first syringe needle 113; Wherein, a medicament 3 can be filled in this syringe 111.。This second body 12 comprises: one extracts end 121, probe tube 122 and one second syringe needle 123; Wherein, this second syringe needle 123 is double needle kenels, and it comprises: acquisition end 1231 and a collecting terminal 1232.
This probe tube 122 of this second body 12 is independently bodys, and it includes: lid 1221 and an accommodation space 1222.This lid 1221 is that the soft rubber material with high adaptation formed, and is covered in this probe tube 122 to make in this accommodation space 1222 and forms Sterile vacuum and negative pressure state.This collecting terminal 1232 being positioned at this extraction end 121 by means of this second syringe needle 123 puncture this probe tube 122 this lid 1221 and run through there is accommodation space 1222 that is aseptic and this probe tube 122 of negative pressure, be positioned at a corpse or other object for laboratory examination and chemical testing for a sampled tissue 91 of a body surface 92 via this acquisition end 1231 collection of this second syringe needle 123 in the mode of pressure differential by this probe tube 122.This medicament 3 in this syringe 111 can puncture into before this sampled tissue 91 surface in this acquisition end 1231 of this first syringe needle 113 and the second syringe needle 123 and detach for departing from this body surface 92 and carry out continuous injection before after sampled tissue 91, so reach and avoid this sampled tissue 91 after an acquisition corpse or other object for laboratory examination and chemical testing, make sick cell (cancerous cell) Release and dispersion in this sampled tissue 91 infect to surrounding normal tissue 93 in this first syringe needle 113 and the path of passing through of the second syringe needle 123 before pulling out this body surface 92 and be even transferred to the risk of other organs.
More than illustrate just illustrative for the purpose of the present invention; and nonrestrictive, those of ordinary skill in the art understand, when not departing from the spirit and scope that claim limits; many amendments, change or equivalence can be made, but all will fall within protection scope of the present invention.
Claims (10)
1. biological tissue's sting device, is characterized in that, it comprises:
One first body, comprising: a syringe, a piston and one first syringe needle; And
One second body, comprising: a probe tube and one second syringe needle;
Wherein, a medicament can be filled in this syringe, and this probe tube is used to provide the corpse or other object for laboratory examination and chemical testing collected this second syringe needle and capture.
2. biological tissue according to claim 1 sting device, is characterized in that, this first syringe needle and this second syringe needle are and pricking with needle.
3. biological tissue according to claim 1 sting device, is characterized in that, this second syringe needle is double needle kenel, and it comprises: acquisition end and a collecting terminal.
4. biological tissue according to claim 3 sting device, is characterized in that, this second body also comprises an extraction end; This probe tube is a freestanding bodies, and it includes: a lid and an accommodation space; Wherein, this probe tube is incorporated in this extraction end of this second body, and this collecting terminal of this second syringe needle is punctured this lid and running through in this accommodation space.
5. biological tissue according to claim 4 sting device, is characterized in that, this lid is that the soft rubber material with high adaptation formed, and is covered in this probe tube to make in this accommodation space and forms negative pressure state.
6. biological tissue according to claim 1 sting device, is characterized in that, this first body and this second body are integrally formed.
7. biological tissue according to claim 1 sting device, is characterized in that, this medicament be can kill the killing cancer cell medicament of cancerous cell or inhibition of cancer cell agent one of them.
8. biological tissue according to claim 1 sting device, is characterized in that, an outer surface of this first syringe needle has a plurality of side openings of an inside pipe wall of this first syringe needle through, to provide injection this medicament.
9. biological tissue according to claim 1 sting device, it is characterized in that, this first syringe needle is concentric pin with this second syringe needle, and this second syringe needle to be positioned within this first syringe needle and to be positioned on same central shaft, and inside pipe wall interval one predeterminable range of an outer surface of this second syringe needle and this first syringe needle is to provide this drug injection.
10. a using method for biological tissue's sting device, it comprises following implementation step:
(A) provide biological tissue's sting device, it comprises: one first body and one second body, and this first body comprises: a syringe, a piston and one first syringe needle; This second body comprises: a probe tube and one second syringe needle; Wherein, in this syringe, a medicament is filled with;
(B) this first syringe needle of this first body and this second syringe needle of this second body are inserted in a body surface simultaneously;
(C) make this first syringe needle and this second syringe needle move closer to while a sampled tissue surface, this piston pushing this first syringe needle makes this medicament in this syringe inject in advance;
(D) will at least the puncture of this second syringe needle enter in sampled tissue, and now this first syringe needle stops this medicament of injection;
(E) this probe tube being incorporated into one of this second body extracts in end, the lid that the collecting terminal being positioned at this extraction end by means of this second syringe needle punctures on this probe tube, and run through in the accommodation space in negative pressure in this probe tube, and a sick cell corpse or other object for laboratory examination and chemical testing for this sampled tissue of acquisition is held to enter in this accommodation space of this probe tube by the mode of pressure differential via an acquisition of this second syringe needle;
(F) when will at least this second syringe needle pulls out this sampled tissue surface time, make this medicament of continuous injection in this syringe, until this first syringe needle and this second syringe needle are pulled out body surface outer after stop this medicament to stop injecting immediately; And
(G) this probe tube of a sick cell corpse or other object for laboratory examination and chemical testing for this sampled tissue there is is to take out by this extraction end of this second body acquisition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410002972.4A CN104758008A (en) | 2014-01-03 | 2014-01-03 | Biological tissue puncture device and biological tissue puncture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410002972.4A CN104758008A (en) | 2014-01-03 | 2014-01-03 | Biological tissue puncture device and biological tissue puncture method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104758008A true CN104758008A (en) | 2015-07-08 |
Family
ID=53640360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410002972.4A Pending CN104758008A (en) | 2014-01-03 | 2014-01-03 | Biological tissue puncture device and biological tissue puncture method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104758008A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617488A (en) * | 2016-03-16 | 2016-06-01 | 中国人民解放军第二军医大学 | Disposable press-type first-aid injector for pre-filled medicine liquid |
| CN110393836A (en) * | 2019-08-07 | 2019-11-01 | 郑州大学第一附属医院 | Have an X-rayed medicament injection apparatus in downtake tumour |
| CN112481103A (en) * | 2020-11-26 | 2021-03-12 | 上海伊弗特生物医药科技有限公司 | High-efficient immune cell sampling device |
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|---|---|---|---|---|
| US3604410A (en) * | 1968-09-11 | 1971-09-14 | Gary L Whitacre | Multitube blood sampler |
| US3749084A (en) * | 1971-05-03 | 1973-07-31 | A Cucchiara | Sequentially dispensing syringe with multiple needle assembly |
| US6702760B2 (en) * | 2000-11-06 | 2004-03-09 | Bioengineering Consultants | Biopsy and coagulant device |
| US20090240208A1 (en) * | 2008-03-19 | 2009-09-24 | Warsaw Orthopedic, Inc. | Microparticle delivery syringe and needle for placing particle suspensions and removing vehicle fluid |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3604410A (en) * | 1968-09-11 | 1971-09-14 | Gary L Whitacre | Multitube blood sampler |
| US3749084A (en) * | 1971-05-03 | 1973-07-31 | A Cucchiara | Sequentially dispensing syringe with multiple needle assembly |
| US6702760B2 (en) * | 2000-11-06 | 2004-03-09 | Bioengineering Consultants | Biopsy and coagulant device |
| US20090240208A1 (en) * | 2008-03-19 | 2009-09-24 | Warsaw Orthopedic, Inc. | Microparticle delivery syringe and needle for placing particle suspensions and removing vehicle fluid |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617488A (en) * | 2016-03-16 | 2016-06-01 | 中国人民解放军第二军医大学 | Disposable press-type first-aid injector for pre-filled medicine liquid |
| CN110393836A (en) * | 2019-08-07 | 2019-11-01 | 郑州大学第一附属医院 | Have an X-rayed medicament injection apparatus in downtake tumour |
| CN112481103A (en) * | 2020-11-26 | 2021-03-12 | 上海伊弗特生物医药科技有限公司 | High-efficient immune cell sampling device |
| CN112481103B (en) * | 2020-11-26 | 2023-11-28 | 上海伊弗特生物医药科技有限公司 | High-efficient immune cell sampling device |
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