CN104750132A - Testing temperature correction method, controller and testing temperature correction system - Google Patents
Testing temperature correction method, controller and testing temperature correction system Download PDFInfo
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Abstract
The invention discloses a testing temperature correction method, a controller and a testing temperature correction system. The testing temperature correction method includes: detecting temperature of a reaction area; when the detected temperature is lower than a first threshold value, heating to a first threshold value for testing to acquire a target testing result; when the detected temperature is the first threshold value, directly testing to acquire a target value; when the detected temperature is higher than the first threshold value and lower than a second threshold value, correcting a value acquired by testing correspondingly to the temperature to acquire a target value. Testing can be performed in different temperature conditions, temperature adjusting or testing result correction is performed according to a relation between temperature of a current reaction area and threshold temperature to acquire an accurate testing result, and requirements on constant temperature of testing equipment are not needed basically, so that the accurate testing result can be acquired with low cost, and accuracy and efficiency in testing are improved.
Description
Technical field
The present invention relates to biomedical field tests, particularly relate to a kind of probe temperature bearing calibration, controller and probe temperature corrective system.
Background technology
Some biomedical tests, as in microdose urine protein testing process, temperature can have a great impact test result.
Present most of microdose urine protein testing adopts immunoturbidimetry, it adopts large-scale biochemical instruments testing of equipment, it needs biochemical instruments constant temperature just must ensure the accuracy of test result at a certain temperature, when environment temperature can promote probe temperature by lower-cost type of heating lower than during specified probe temperature, and it is also fairly simple to increase heating arrangement in a test device, less to the structure influence of proving installation; But when environment temperature is higher than specified probe temperature, substantially cooling object can not be issued in the prerequisite not changing proving installation structure as far as possible with existing means, thermostatic equipment with high costs must be used, therefore existing proving installation want to obtain accurately test result time high to the requirement of instrument constant temperature, if there is no thermostat, cannot test exactly in the inconstant situation of temperature.
Summary of the invention
In view of this, fundamental purpose of the present invention is to provide a kind of probe temperature bearing calibration, controller and probe temperature corrective system, can be ensured the accuracy of test result by lower cost under different temperatures environment.
For achieving the above object, the invention provides a kind of probe temperature bearing calibration, comprising:
Detection reaction regional temperature;
When described conversion zone temperature is lower than first threshold temperature, start the test of preset content after heating conversion zone to first threshold temperature, using test value as desired value;
When described conversion zone temperature is first threshold temperature, directly start the test of preset content, using test value as desired value;
When described conversion zone temperature is higher than first threshold temperature and lower than Second Threshold temperature, directly start the test of preset content, after obtaining test value, obtain corresponding correction function according to conversion zone temperature, utilize described correction function to carry out correction to test value and obtain desired value.
Preferably, obtain corresponding correction function according to conversion zone temperature to comprise:
Obtain correction function set, choose comprise in described correction function set with the immediate temperature value of current conversion zone temperature, correction function corresponding for this temperature value is defined as correction function corresponding to current conversion zone temperature.
Preferably, described correction function is the linear relationship function comprising the first correction coefficient and the second correction coefficient.
Preferably, obtain correction function set to comprise:
Determine each experimental concentration value of the first preset number;
Determine higher than first threshold temperature and each experimental temperature value of the second preset number lower than Second Threshold temperature;
The test of the preset content of each experimental concentration is carried out respectively, each experiment test value corresponding with each experimental concentration under obtaining often kind of experimental temperature value when conversion zone temperature is each experimental temperature value;
Under conversion zone temperature is first threshold temperature, carries out the test of the preset content of each experimental concentration, obtains each reference test value corresponding with each experimental concentration;
When the reference test value corresponding according to each experimental concentration and experiment test value obtain conversion zone concentration for often kind of experimental temperature value, corresponding experiment test value and conversion zone temperature are the first correction coefficient with reference to test value and second correction coefficient of first threshold temperature;
The first correction coefficient according to often kind of experimental temperature value obtains corresponding correction function with the second correction coefficient.
Present invention also offers a kind of controller, be applied to probe temperature and correct, described controller comprises:
Judge module, for judging the size of conversion zone temperature and first threshold temperature and the Second Threshold temperature detected;
Control heating module, for heating conversion zone to first threshold temperature when conversion zone temperature lower than controlling during first threshold temperature;
Test module, for when conversion zone temperature is not less than first threshold temperature, the test carrying out preset content obtains test value;
Correction module, for when conversion zone temperature is higher than first threshold temperature and lower than Second Threshold temperature, obtains corresponding correction function according to conversion zone temperature, utilizes described correction function to carry out correction to test value and obtain desired value.
Preferably, described correction module comprises:
Correction function obtains submodule, for obtaining correction function set, choose comprise in described correction function set with the immediate temperature value of current conversion zone temperature, correction function corresponding for this temperature value is defined as correction function corresponding to current conversion zone temperature.
Preferably, described correction function is the linear relationship function comprising the first correction coefficient and the second correction coefficient.
Preferably, described correction function acquisition submodule comprises:
Correction function set obtains submodule, for determining each experimental concentration value of the first preset number;
Determine higher than first threshold temperature and each experimental temperature value of the second preset number lower than Second Threshold temperature;
The test of the preset content of each experimental concentration is carried out respectively, each experiment test value corresponding with each experimental concentration under obtaining often kind of experimental temperature value when conversion zone temperature is each experimental temperature value;
Under conversion zone temperature is first threshold temperature, carries out the test of the preset content of each experimental concentration, obtains each reference test value corresponding with each experimental concentration;
When the reference test value corresponding according to each experimental concentration and experiment test value obtain conversion zone concentration for often kind of experimental temperature value, corresponding experiment test value and conversion zone temperature are the first correction coefficient with reference to test value and second correction coefficient of first threshold temperature;
The first correction coefficient according to often kind of experimental temperature value obtains corresponding correction function with the second correction coefficient.
Preferably, described controller also comprises memory module, for storing correction function corresponding to described each conversion zone temperature.
Present invention also offers a kind of probe temperature corrective system, comprise described controller, also comprise:
Temperature sensor, be connected with the input end of described controller, for detection reaction regional temperature, this temperature information sent to described controller;
Heating arrangement, is connected with the output terminal of described controller, and the control information for sending according to described controller promotes conversion zone temperature.
Apply probe temperature bearing calibration provided by the invention, controller and probe temperature corrective system, detection reaction regional temperature, when the temperature detected is tested lower than being heated to first threshold during first threshold, obtain target detection result, directly carry out test when the temperature detected is first threshold and obtain desired value, when the temperature detected obtains desired value lower than during Second Threshold to the correction testing the value that obtains and carry out corresponding to this temperature higher than first threshold, can test in different temperatures situation, temperature adjustment is carried out or test result corrects to obtain test result accurately according to current conversion zone temperature and threshold temperature relation, constant temperature requirement is not had substantially to testing apparatus, test result comparatively accurately can be obtained by lower cost, improve accuracy and the efficiency of test.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only embodiments of the invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to the accompanying drawing provided.
Fig. 1 is the process flow diagram of probe temperature bearing calibration of the present invention;
Fig. 2 is the detail flowchart of probe temperature bearing calibration of the present invention;
Fig. 3 is the structural representation of controller of the present invention;
Fig. 4 is the another structural representation of controller of the present invention;
Fig. 5 is the structural representation of probe temperature corrective system of the present invention.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
The invention provides a kind of probe temperature bearing calibration, as described in Figure 1, be the first specific embodiment of probe temperature bearing calibration of the present invention, comprise:
Step S101: detection reaction regional temperature;
Detect the temperature value obtaining current conversion zone.
Step S102: judge that whether described conversion zone temperature is lower than first threshold temperature, if so, then enters step S103, otherwise enters step S104;
During as carried out urine micro protein test, preset first threshold value temperature is 24 DEG C.
Step S103: the test starting preset content after heating conversion zone to first threshold temperature, using test value as desired value;
When conversion zone temperature is lower than first threshold temperature 24 DEG C, directly test after 24 DEG C are heated to conversion zone, and using test value as final goal value.
Step S104: judge whether described conversion zone temperature is first threshold temperature, if so, then enters step S105, otherwise enters step S106;
Judge when conversion zone temperature is not less than first threshold temperature 24 DEG C whether conversion zone temperature is 24 DEG C.
Step S105: the test directly starting preset content, using test value as desired value;
Directly test when conversion zone temperature is 24 DEG C, using test value as final goal value.
Step S106: judge that whether described conversion zone temperature is higher than first threshold temperature and lower than Second Threshold temperature, if so, then enters step S107;
Judge that when conversion zone temperature is not below or equal to first threshold temperature whether conversion zone temperature is higher than first threshold temperature and lower than Second Threshold temperature, presetting Second Threshold temperature is 37 DEG C.
Step S107: the test directly starting preset content, after obtaining test value, obtains corresponding correction function according to conversion zone temperature, utilizes described correction function to carry out correction to test value and obtain desired value.
When conversion zone temperature is higher than 24 DEG C and lower than directly starting test when 37 DEG C, obtain temperature is corresponding instantly correction function after obtaining test value to carry out correction to test value and obtain desired value, particularly, obtain corresponding correction function according to conversion zone temperature to comprise: obtain correction function set, choose comprise in described correction function set with the immediate temperature value of current conversion zone temperature, correction function corresponding for this temperature value is defined as correction function corresponding to current conversion zone temperature.
The probe temperature bearing calibration that application the present embodiment provides, detection reaction regional temperature, when the temperature detected is tested lower than being heated to first threshold during first threshold, obtain target detection result, directly carry out test when the temperature detected is first threshold and obtain desired value, when the temperature detected obtains desired value lower than during Second Threshold to the correction testing the value that obtains and carry out corresponding to this temperature higher than first threshold, can test in different temperatures situation, temperature adjustment is carried out or test result corrects to obtain test result accurately according to current conversion zone temperature and threshold temperature relation, constant temperature requirement is not had substantially to testing apparatus, test result comparatively accurately can be obtained by lower cost, improve accuracy and the efficiency of test.
The another embodiment of temperature test bearing calibration of the present invention, arranging described correction function is the linear relationship function comprising the first correction coefficient and the second correction coefficient,
As shown in Figure 2, concrete, obtain correction function set and comprise:
Step S201: each experimental concentration value determining the first preset number;
As arranged gradient close 5 different experiments concentration values C1, C2, C3, C4, C5.
Step S202: determine higher than first threshold temperature and each experimental temperature value of the second preset number lower than Second Threshold temperature;
As arrange close 6 the different experiments temperature values 26 DEG C of gradient, 28 DEG C, 30 DEG C, 32 DEG C, 34 DEG C, 36 DEG C.
Step S203: the test carrying out the preset content of each experimental concentration when conversion zone temperature is each experimental temperature value respectively, each experiment test value corresponding with each experimental concentration under obtaining often kind of experimental temperature value;
The test carrying out 5 different experiments concentration under 6 the different experiments temperature conditionss arranged respectively obtains experiment test value.
Step S204: the test carrying out the preset content of each experimental concentration under conversion zone temperature is first threshold temperature, obtains each reference test value corresponding with each experimental concentration;
The test of 5 variable concentrations of described setting is carried out in first threshold temperature 24 DEG C of situations, the result obtained is the reference test value of each concentration, as shown in table 1 below, the test result for each experimental temperature value and the lower 5 kinds of experimental concentration values of first threshold temperature conditions:
Table 1
Step S205: according to each experimental concentration corresponding obtain with reference to test value and experiment test value the first correction coefficient and the second correction coefficient that experiment test value corresponding when conversion zone concentration is often kind of experimental temperature value and conversion zone temperature are the reference test value of first threshold temperature;
For 26 DEG C, can test value C01, C02, C03, C04, C05 of 24 DEG C be ordinate, with test value C11, C21, C31, C41, C51 of 26 DEG C for horizontal ordinate, obtain five points in a coordinate system, carry out a loose some line and set up linear equation C=k
26* C
1+ b
26, obtain the first correction coefficient k
26with the second correction coefficient b
26, similarly also can obtain the first correction coefficient k and the second correction coefficient b of other temperature.
Step S206: the first correction coefficient according to often kind of experimental temperature value obtains corresponding correction function with the second correction coefficient.
As following table 2, it is the correction function obtained according to the first correction coefficient and the second correction coefficient.
Table 2
Correction function is determined according to upper table the first correction coefficient k and the second correction coefficient b.
When carrying out the bearing calibration of this probe temperature, correction function set is the linear relationship set obtained, can directly choose comprise in correction function set with the immediate temperature value of current conversion zone temperature, correction function corresponding for this temperature value is defined as correction function corresponding to current conversion zone temperature.
The present embodiment instrument test obtains test value C
0, detection reaction regional temperature T, chooses the correction function mated with temperature T-phase, all can adopt the correction function of this temperature t when temperature T is positioned at about the temperature t 1 DEG C of correction function acquisition.Particularly as following table:
Table 3
| T(℃) | Correction function |
| 24﹤T≤25 | C＝C 0 |
| 25﹤T≤27 | C＝k 26*C 1+b 26 |
| 27﹤T≤29 | C＝k 28*C 2+b 28 |
| 29﹤T≤31 | C＝k 30*C 3+b 30 |
| 31﹤T≤33 | C＝k 32*C 4+b 32 |
| 33﹤T≤35 | C＝k 34*C 5+b 34 |
| 35﹤T≤37 | C＝k 36*C 6+b 36 |
| T﹥37 | Do not correct |
Such as during test, conversion zone temperature is in T=26 DEG C ± 1 DEG C situation, and the correction function of employing is that the correction function in t=26 DEG C of situation calculates final goal value.
As shown in following table 4 ~ table 8, before and after the probe temperature bearing calibration for application the present embodiment, carry out the test comparison result of urine micro protein:
Presetting 24 DEG C is first threshold temperature, and 37 DEG C is Second Threshold temperature.
Table 4
Table 5
Table 6
Table 7
Table 8
The data of above-mentioned experimental result show that this method carries out test result correction when testing microdose urine protein according to temperature, the interference of temperature to test result can well be solved, require also lower to the temperature control of instrument simultaneously, constant temperature requirement is not had substantially to testing apparatus, test result comparatively accurately can be obtained by lower cost, improve accuracy and the efficiency of test.
Present invention also offers a kind of controller, be applied to probe temperature and correct, as shown in Figure 3, be the structural representation of controller of the present invention, described controller comprises:
Judge module 101, for judging the size of conversion zone temperature and first threshold temperature and the Second Threshold temperature detected;
Control heating module 102, for heating conversion zone to first threshold temperature when conversion zone temperature lower than controlling during first threshold temperature;
Test module 103, for when conversion zone temperature is not less than first threshold temperature, the test carrying out preset content obtains test value;
Correction module 104, for when conversion zone temperature is higher than first threshold temperature and lower than Second Threshold temperature, obtains corresponding correction function according to conversion zone temperature, utilizes described correction function to carry out correction to test value and obtain desired value.
The another specific embodiment of controller of the present invention, particularly, described correction module comprises:
Correction function obtains submodule, for obtaining correction function set, choose comprise in described correction function set with the immediate temperature value of current conversion zone temperature, correction function corresponding for this temperature value is defined as correction function corresponding to current conversion zone temperature.
Correction function described in the present embodiment is the linear relationship function comprising the first correction coefficient and the second correction coefficient.
Described correction function obtains submodule and comprises:
Correction function set obtains submodule, for determining each experimental concentration value of the first preset number;
Determine higher than first threshold temperature and each experimental temperature value of the second preset number lower than Second Threshold temperature;
The test of the preset content of each experimental concentration is carried out respectively, each experiment test value corresponding with each experimental concentration under obtaining often kind of experimental temperature value when conversion zone temperature is each experimental temperature value;
Under conversion zone temperature is first threshold temperature, carries out the test of the preset content of each experimental concentration, obtains each reference test value corresponding with each experimental concentration;
When the reference test value corresponding according to each experimental concentration and experiment test value obtain conversion zone concentration for often kind of experimental temperature value, corresponding experiment test value and conversion zone temperature are the first correction coefficient with reference to test value and second correction coefficient of first threshold temperature;
The first correction coefficient according to often kind of experimental temperature value obtains corresponding correction function with the second correction coefficient.
As shown in Figure 4, be the another specific embodiment of controller of the present invention, corresponding to Fig. 3, also comprise: memory module 105, for storing correction function corresponding to described each conversion zone temperature.
Present invention also offers a kind of probe temperature corrective system, as shown in Figure 5, is the structural representation of a specific embodiment, comprises the controller 201 that power is above-mentioned, also comprises:
Temperature sensor 202, be connected with the input end of described controller, for detection reaction regional temperature, this temperature information sent to described controller;
Heating arrangement 203, is connected with the output terminal of described controller, and the control information for sending according to described controller promotes conversion zone temperature.
The probe temperature corrective system that application the present embodiment provides, detection reaction regional temperature, when the temperature detected is tested lower than being heated to first threshold during first threshold, obtain target detection result, directly carry out test when the temperature detected is first threshold and obtain desired value, when the temperature detected obtains desired value lower than during Second Threshold to the correction testing the value that obtains and carry out corresponding to this temperature higher than first threshold, can test in different temperatures situation, temperature adjustment is carried out or test result corrects to obtain test result accurately according to current conversion zone temperature and threshold temperature relation, constant temperature requirement is not had substantially to testing apparatus, test result comparatively accurately can be obtained by lower cost, improve accuracy and the efficiency of test.
For apparatus system class embodiment, due to itself and embodiment of the method basic simlarity, so description is fairly simple, relevant part illustrates see the part of embodiment of the method.
It should be noted that, each embodiment in this instructions all adopts the mode of going forward one by one to describe, and what each embodiment stressed is the difference with other embodiments, between each embodiment identical similar part mutually see.
Finally, also it should be noted that, in this article, the such as relational terms of first and second grades and so on is only used for an entity or operation to separate with another entity or operational zone, and not necessarily requires or imply the relation that there is any this reality between these entities or operation or sequentially.And, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thus make to comprise the process of a series of key element, method, article or equipment and not only comprise those key elements, but also comprise other key elements clearly do not listed, or also comprise by the intrinsic key element of this process, method, article or equipment.When not more restrictions, the key element limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment comprising described key element and also there is other identical element.
Above method, controller and system that the application provides are described in detail, apply specific case herein to set forth the principle of the application and embodiment, the explanation of above embodiment is just for helping method and the core concept thereof of understanding the application; Meanwhile, for one of ordinary skill in the art, according to the thought of the application, all will change in specific embodiments and applications, in sum, this description should not be construed as the restriction to the application.
Claims (10)
1. a probe temperature bearing calibration, is characterized in that, comprising:
Detection reaction regional temperature;
When described conversion zone temperature is lower than first threshold temperature, start the test of preset content after heating conversion zone to first threshold temperature, using test value as desired value;
When described conversion zone temperature is first threshold temperature, directly start the test of preset content, using test value as desired value;
When described conversion zone temperature is higher than first threshold temperature and lower than Second Threshold temperature, directly start the test of preset content, after obtaining test value, obtain corresponding correction function according to conversion zone temperature, utilize described correction function to carry out correction to test value and obtain desired value.
2. probe temperature bearing calibration according to claim 1, is characterized in that, obtains corresponding correction function comprise according to conversion zone temperature:
Obtain correction function set, choose comprise in described correction function set with the immediate temperature value of current conversion zone temperature, correction function corresponding for this temperature value is defined as correction function corresponding to current conversion zone temperature.
3. temperature test bearing calibration according to claim 2, is characterized in that, described correction function is the linear relationship function comprising the first correction coefficient and the second correction coefficient.
4. temperature test bearing calibration according to claim 3, is characterized in that, obtains correction function set and comprises:
Determine each experimental concentration value of the first preset number;
Determine higher than first threshold temperature and each experimental temperature value of the second preset number lower than Second Threshold temperature;
The test of the preset content of each experimental concentration is carried out respectively, each experiment test value corresponding with each experimental concentration under obtaining often kind of experimental temperature value when conversion zone temperature is each experimental temperature value;
Under conversion zone temperature is first threshold temperature, carries out the test of the preset content of each experimental concentration, obtains each reference test value corresponding with each experimental concentration;
When the reference test value corresponding according to each experimental concentration and experiment test value obtain conversion zone concentration for often kind of experimental temperature value, corresponding experiment test value and conversion zone temperature are the first correction coefficient with reference to test value and second correction coefficient of first threshold temperature;
The first correction coefficient according to often kind of experimental temperature value obtains corresponding correction function with the second correction coefficient.
5. a controller, is characterized in that, be applied to probe temperature and correct, described controller comprises:
Judge module, for judging the size of conversion zone temperature and first threshold temperature and the Second Threshold temperature detected;
Control heating module, for heating conversion zone to first threshold temperature when conversion zone temperature lower than controlling during first threshold temperature;
Test module, for when conversion zone temperature is not less than first threshold temperature, the test carrying out preset content obtains test value;
Correction module, for when conversion zone temperature is higher than first threshold temperature and lower than Second Threshold temperature, obtains corresponding correction function according to conversion zone temperature, utilizes described correction function to carry out correction to test value and obtain desired value.
6. controller according to claim 5, is characterized in that, described correction module comprises:
Correction function obtains submodule, for obtaining correction function set, choose comprise in described correction function set with the immediate temperature value of current conversion zone temperature, correction function corresponding for this temperature value is defined as correction function corresponding to current conversion zone temperature.
7. controller according to claim 6, is characterized in that, described correction function is the linear relationship function comprising the first correction coefficient and the second correction coefficient.
8. controller according to claim 6, is characterized in that, described correction function obtains submodule and comprises:
Correction function set obtains submodule, for determining each experimental concentration value of the first preset number;
Determine higher than first threshold temperature and each experimental temperature value of the second preset number lower than Second Threshold temperature;
The test of the preset content of each experimental concentration is carried out respectively, each experiment test value corresponding with each experimental concentration under obtaining often kind of experimental temperature value when conversion zone temperature is each experimental temperature value;
Under conversion zone temperature is first threshold temperature, carries out the test of the preset content of each experimental concentration, obtains each reference test value corresponding with each experimental concentration;
When the reference test value corresponding according to each experimental concentration and experiment test value obtain conversion zone concentration for often kind of experimental temperature value, corresponding experiment test value and conversion zone temperature are the first correction coefficient with reference to test value and second correction coefficient of first threshold temperature;
The first correction coefficient according to often kind of experimental temperature value obtains corresponding correction function with the second correction coefficient.
9. the controller according to any one of claim 5 ~ 8, is characterized in that, also comprises memory module, for storing correction function corresponding to described each conversion zone temperature.
10. a probe temperature corrective system, is characterized in that, comprises the controller described in any one of claim 5 ~ 9, also comprises:
Temperature sensor, be connected with the input end of described controller, for detection reaction regional temperature, this temperature information sent to described controller;
Heating arrangement, is connected with the output terminal of described controller, and the control information for sending according to described controller promotes conversion zone temperature.
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| CN112432988A (en) * | 2020-11-25 | 2021-03-02 | 重庆迈联医疗科技有限公司 | Temperature correction method of electrochemical test system |
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| CN104750132B (en) | 2017-03-15 |
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