CN104740459A

CN104740459A - Traditional Chinese medicine composition for treating cough

Info

Publication number: CN104740459A
Application number: CN201410293829.5A
Authority: CN
Inventors: 陶红苗; 胡野
Original assignee: Jinhua Polytechnic
Current assignee: Jinhua Polytechnic
Priority date: 2014-06-19
Filing date: 2014-06-19
Publication date: 2015-07-01

Abstract

The invention relates to a traditional Chinese medicine composition for treating cough. The traditional Chinese medicine composition for treating cough comprises the following raw material medicines in parts by weight: 10 parts of lily flower, 10 parts of poria cocos, 9 parts of apricot, 8 parts of liquorice, 8 parts of angelica sinensis, 7 parts of honeysuckle, 6 parts of radix ophiopogonis, 6 parts of wolfberry, 6 parts of radix stemonae, 5 parts of flos farfarae, 4 parts of radix adenophorae, 3 parts of rhizoma anemarrhenae, 3 parts of periostracum cicada, and 3 parts of fritillary.

Description

A kind of Chinese medicine composition for the treatment of cough

Technical field

The invention belongs to tcm field, a kind of Chinese medicine composition for the treatment of cough is provided especially.

Background technology

Cough refers to impairment of dispersing and descending function of the lung, and abnormal rising of lung-QI is uttered a word, and coughs liquid of spitting.The traditional Chinese medical science think sound without expectorant for coughing, have expectorant noiseless for coughing, usually both and see, therefore and claim cough.Cough is one of main syndromes of lung pattern disease, is also one of clinical symptom the most common, often comes across various diseases.The traditional Chinese medical science is thought, cough has the large class of diseases caused by exogenous pathogenic factor, internal injury two.Current treatment cough method is a lot, be mainly divided into Chinese traditional treatment and western medical treatment, and doctor trained in Western medicine mainly adopts antibiotic therapy.It is large and easily form the drawbacks such as dependency that antibiotic therapy has side effect, and compare with it, and Chinese traditional treatment has the many advantages such as treating both the principal and secondary aspects of a disease, side effect be little.

Summary of the invention

The invention provides a kind of Chinese medicine composition being used for the treatment of cough, it is characterized in that, described medicine is made up of the crude drug of following weight proportion: Bulbus Lilii 10 parts, 10 parts, Poria, 9 parts, Semen Armeniacae Amarum, 8 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 8 parts, Flos Lonicerae 7 parts, Radix Ophiopogonis 6 parts, Radix Platycodonis 6 parts, Fructus Lycii 6 parts, the Radix Stemonae 6 parts, Flos Farfarae 5, Radix Adenophorae (Radix Glehniae) 4 parts, the Rhizoma Anemarrhenae 3 parts, Periostracum Cicadae 3 parts, Bulbus Fritillariae Uninbracteatae 3 parts.

Preparation method, for getting above crude drug, puts into container, adds the dipped powder of cold water, soaks 15-20 minute, then adds water and do not have powder about 8 centimetres, decoct.Decoct with high heat at a simmer, with slow fire boiling 20-30 minute after boiling, second time decocts, with slow fire boiling 15-20 minute after boiling.Twice decoction is removed slag extracting juice, merges.

Detailed description of the invention

Embodiment 1

Bulbus Lilii 10 parts, 10 parts, Poria, 9 parts, Semen Armeniacae Amarum, 8 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 8 parts, Flos Lonicerae 7 parts, Radix Ophiopogonis 6 parts, Radix Platycodonis 6 parts, Fructus Lycii 6 parts, the Radix Stemonae 6 parts, Flos Farfarae 5, Radix Adenophorae (Radix Glehniae) 4 parts, the Rhizoma Anemarrhenae 3 parts, Periostracum Cicadae 3 parts, Bulbus Fritillariae Uninbracteatae 3 parts.

Reference substance 1

A kind of pharmaceutical composition for the treatment of cough disclosed in CN102988735A, the weight proportion of its Raw is as follows: 10 parts, Herba Ephedrae, 10 parts, Semen Armeniacae Amarum, 15 parts, Radix Glycyrrhizae, 15 parts, Poria, 15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), the Radix Paeoniae Alba 15 parts, Rhizoma Dioscoreae 20 parts, Bulbus Lilii 20 parts, Radix Ophiopogonis 15 parts, Radix Adenophorae (Radix Glehniae) 15 parts, Cortex Magnoliae Officinalis 12 parts, Radix Asteris 15 parts, Flos Farfarae 15 parts, the Rhizoma Pinelliae 12 parts, the Rhizoma Anemarrhenae 15 parts, Radix Pseudostellariae 15 parts, Rhizoma Belamcandae 15 parts, Periostracum Cicadae 20 parts.

Reference substance 2

A kind of Chinese medicine preparation for the treatment of cough disclosed in CN102552774A, wherein containing Radix Isatidis 9 parts, Rhizoma Osmundae 9 parts, Flos Lonicerae 21 parts, Radix Scutellariae 21 parts, Folium Eriobotryae 9 parts, the Radix Stemonae 9 parts, Bulbus Fritillariae Thunbergii 9 parts, Herba Menthae 9 parts.

Experimental example 2: the present invention causes the antitussive effect of mouse cough model to strong aqua ammonia nebulization

By the mice 50 of SPF level body weight 18-22g, be divided into 5 groups at random, blank group gives gavage normal saline, tested group gives each 2.0g/kg of drug sample described in gavage embodiment 1 and reference substance 1,2, positive controls gives antiasthmatic pill of perilla fruit 2.0g/kg, each gavage Chinese medicine volume is about 1ml/100g, 1 time/d, successive administration 7 days.After last administration 30 minutes, inserted by mice and be added with luring to cough to draw and breathing heavily in instrument of strong aqua ammonia, atomization 15s, observed in mouse cough incubation period (occurring the time of cough from spraying to mice) and 3 minutes number of times of coughing, result with represent, t checks more each group difference.The results are shown in Table 1.

Table 1 medicine of the present invention to strong aqua ammonia nebulization cause mouse cough antitussive effect ( n=10)

Group	Dosage (g/kg)	Incubation period (second)	Cough number of times (secondary)
				Embodiment 1	2.0	39.2±13.8 _☆☆	12.3±3.3 _☆☆
Reference substance 1	2.0	28.6±9.3 _☆☆	15.3±3.8 _☆
				Reference substance 2	2.0	26.5±5.8 _☆☆	15.9±4.3 _☆
Antiasthmatic pill of perilla fruit group	2.0	30.8±8.4 _☆☆	14.3±4.6 _☆☆
				Blank group	----	15.6±7.5	22.1±7.2

Note: compare with blank group, _☆p < 0.05, _{☆ ☆}p < 0.01

As can be seen from Table 1, medicine of the present invention can reduce cough number of times, and extends cough latent period.Medicine of the present invention has obvious antitussive effect, and effect is better than antiasthmatic pill of perilla fruit and reference substance 1,2.

Embodiment 3 clinical therapeutic efficacy

1. physical data

Have collected 400 routine deficiency of kidney yin syndrome cough out-patients between in March ,-2014 in July, 2008 altogether, wherein, man 226 example, female 174 example, age 19-78 year, the course of disease 1 day-3 months is not etc.Random number method is adopted to be divided into treatment group and each 200 examples of matched group at random.Two groups of ages, sex, course of disease isobase data there was no significant difference, have comparability.

2. experimental technique

Matched group takes baihe gujin decoction, takes to specifications, 7 days courses for the treatment of.

The decoction that the oral the present invention for the treatment of group makes, every day 1 pair, divides and takes for 2 times, 7 days courses for the treatment of.

3. criterion of therapeutical effect

Cure clinical symptoms all to disappear;

Improvement clinical symptoms obviously alleviates;

Invalid clinical symptoms has no to disappear or increase the weight of.

4. therapeutic outcome

1 course for the treatment of terminates rear observation therapeutic outcome.Treatment group cures 186 examples, and take a turn for the better 14 examples, and invalid 0 example, cure rate is 93%, and effective percentage is 100%.Matched group cures 122 examples, and take a turn for the better 45 examples, and invalid 33 examples, cure rate is 61%, and effective percentage is 84%, and the cure rate for the treatment of group, effective percentage are all apparently higher than matched group, and difference all has statistical significance.Show that drug sample of the present invention a kind ofly treats the ideal Chinese medicine of cough, the clinical therapeutic efficacy of cough can be significantly improved.

Claims

1. be used for the treatment of a Chinese medicine composition for cough, wherein the weight proportion of crude drug is approximately as follows: Bulbus Lilii 10 parts, 10 parts, Poria, 9 parts, Semen Armeniacae Amarum, 8 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 8 parts, Flos Lonicerae 7 parts, Radix Ophiopogonis 6 parts, Radix Platycodonis 6 parts, Fructus Lycii 6 parts, the Radix Stemonae 6 parts, Flos Farfarae 5, Radix Adenophorae (Radix Glehniae) 4 parts, the Rhizoma Anemarrhenae 3 parts, Periostracum Cicadae 3 parts, Bulbus Fritillariae Uninbracteatae 3 parts.