CN104739730A - Preparation method for degerming, itching-relieving and mosquito-repelling floral water - Google Patents
Preparation method for degerming, itching-relieving and mosquito-repelling floral water Download PDFInfo
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- CN104739730A CN104739730A CN201510189971.XA CN201510189971A CN104739730A CN 104739730 A CN104739730 A CN 104739730A CN 201510189971 A CN201510189971 A CN 201510189971A CN 104739730 A CN104739730 A CN 104739730A
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Abstract
The invention discloses a preparation method for degerming, itching-relieving and mosquito-repelling floral water. The preparation method comprises the following steps: drying artemisia annua and vitex in shade respectively, crushing the dried artemisia annua and vitex, adding enzymatic hydrolysate 2-8 times the amount of the artemisia annua and vitex to perform enzymolysis at 40-50 DEG C; (2) respectively adding 90%-95% alcohol as a solvent, performing tank group type dynamic countercurrent extraction, concentrating to the mass 3-5 times that of the raw materials under reduced pressure after the reaction, and standing for later use, wherein the volume mass ratio of the solvent to the raw herbal materials is 15: 1 to 20:1; and (3) getting vitex and artemisia annua liquid supernatant with a volume ratio of vitex to artemisia annua of 1:1 to 1:1.5, mixing, adding 95% alcohol one third the total volume of the liquid supernatant, and standing clear liquor to obtain a floral water product. According to the preparation method disclosed by the invention, various technologies of complex enzyme preparation enzymolysis, tank group type dynamic countercurrent extraction, vacuum enhancement mass transfer, and the like are effectively integrated, so that the optimal effects of preparing degerming, itching-relieving and mosquito-repelling floral water by taking vitex and artemisia annua as main raw materials are achieved, the market competitiveness is strong, and the application prospect is wide.
Description
Technical field
The present invention relates to a kind of manufacture method of degerming, antipruritic, mosquito-repellent perfume, specifically refer to from Herba Viticis Cannabifoliae and Herba Artemisiae annuae, extract functional components that is degerming, antipruritic, anophelifuge, and be made into the method for floral water.
Background technology
Herba Artemisiae annuae (
artemisia annual
.) be the annual herb plant of Compositae artemisia, be China's Chinese medicine, its effective ingredient-arteannuin is used for the value of malaria control by human knowledge and acceptance, but other effect of Herba Artemisiae annuae and be worth the further exploitation of the people that need.
Herba Viticis Cannabifoliae
(Vitex negundo L.)have another name called that paving is fragrant, the period of the day from 11 a.m. to 1 p.m careless, native Radix Bupleuri, mosquito bavin, mainly be distributed in the ground such as Jiangsu, Zhejiang, Anhui, Jiangxi, Fujian, Hunan, Guangxi, Guizhou, present stage is mainly used in the symptoms such as treatment inguinal hernia, wind syndrome of head headache, damp-phlegm nebulousurine and sore throat skin ulcer swell, and it further acts on and be worth and also awaits people's development and utilization.
Floral water is the daily chemical products that use amount is very large, is endowed the functions such as degerming, antipruritic, anophelifuge, especially large in the use amount in summer.But, existing floral water adopts the composition of synthetic mostly, the floral water be made with Plant functional composition is completely little, the functional components in Herba Artemisiae annuae and Fructus Viticis Cannabifoliae exploitation is utilized to have pure natural floral water that is degerming, antipruritic, function of driving mosquitoes, for promoting the added value of Herba Artemisiae annuae and Herba Viticis Cannabifoliae, widening the industry bore of Herba Artemisiae annuae and Herba Viticis Cannabifoliae, and safeguard that human body health is all significant.
But degerming, antipruritic, the function of driving mosquitoes composition that how to extract to greatest extent in Herba Artemisiae annuae and Fructus Viticis Cannabifoliae, and preferably these are degerming, antipruritic, function of driving mosquitoes composition also has certain volatility, being make technical barrier that is degerming, antipruritic, mosquito-repellent perfume, is also the technical problem do not solved present stage.
Summary of the invention
For solving above-mentioned prior art Problems existing, the present inventor, through a large amount of tests, gropes and sums up a kind of with Herba Artemisiae annuae and Herba Viticis Cannabifoliae method that is degerming, antipruritic for primary raw material makes, anophelifuge pure natural floral water.
The present invention includes following step:
(1) process of Herba Artemisiae annuae, Herba Viticis Cannabifoliae: Herba Artemisiae annuae and Herba Viticis Cannabifoliae are dried in the shade respectively, shred, adds enzymolysis solution enzymolysis 1-4 hour at the temperature of 40-50 degree of 2-8 times amount respectively in the above-mentioned medical material handled well.
Enzymolysis solution preparation method is: 1-15 gram of compound enzymic preparation to be dissolved in 500ml pH value be in the buffer of 4-7 and get final product.The proportioning of compound enzymic preparation is cellulase mass fraction 60-70%, pectase mass fraction is 15-25%, all the other are xylanase, the average enzyme of compound enzymic preparation is lived as 20000-30000 unit, international zymetology meeting regulation in 1961 is deferred to by described Mei Huo unit, refers under specified conditions (25 DEG C, other is optimal condition), the enzyme amount of 1 micromole substrate can be transformed in 1 minute, or the 1 micromolar enzyme amount about group in conversion of substrate.Prove, with significantly improving extraction ratio that is degerming, antipruritic, function of driving mosquitoes composition after ferment treatment through test.
(2) extraction and concentration of degerming, antipruritic, anophelifuge effective ingredient: the ethanol adding 90%-95% in Herba Artemisiae annuae and Herba Viticis Cannabifoliae enzymolysis solution is respectively solvent, solvent carries out pot group type dynamic countercurrent extraction with the volume mass of raw medicinal material than for 15:1-20:1, extraction time 3-8 hour, Extracting temperature 50-70 DEG C, extracting solution is evaporated to 3-5 times of raw materials quality after extraction completes, stand for standby use.In volume mass ratio, the unit of volume is milliliter, and the unit of quality is gram.
In said extracted process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer.The mechanism of vacuum impulse strengthening mass transfer is: because ethanol is the organic solvent that volatility is stronger, ethanol during evacuation in Herba Artemisiae annuae and Herba Viticis Cannabifoliae cell tissue can gasify because of decompression, cause pressure in Herba Artemisiae annuae and Herba Viticis Cannabifoliae cell tissue to be greater than outside histiocyte, the ethanol having dissolved effective ingredient can be forced through plant cell tissue under differential pressure action; When vacuum breaker, it is intrinsic pressure that Herba Artemisiae annuae and Herba Viticis Cannabifoliae histiocyte external pressure are greater than histiocyte, ethanol outside plant tissue cell enters rapidly histiocyte inside and goes to dissolve effective ingredient because of differential pressure action, the alternate of this plant tissue cell external and internal pressure enhances ethanol and dissolving effective ingredient mass transfer in ethanol, makes extraction efficiency raising, the reduction of effective ingredient residual rate.
(3) making of floral water: get Herba Viticis Cannabifoliae and Herba Artemisiae annuae supernatant, volume ratio is 1:1-1:1.5, and mixing, adds 95% ethanol of 1/3rd cumulative volumes, and leave standstill clarification, clear liquor is floral water product.
Utilize the floral water that the present invention makes, degerming, antipruritic, repelling effect is good, has certain volatility, and pure natural, chemical composition not containing any synthetic, receive praises from customers.
Compared with prior art, beneficial effect of the present invention is also:
Raw medicinal material utilizes compound enzymic preparation to carry out enzymolysis before extracting, and by the cell wall damage of Herba Artemisiae annuae and Herba Viticis Cannabifoliae, enables effective ingredient Fast Stripping, improves extraction ratio that is degerming, antipruritic, anophelifuge effective ingredient.
Compound enzymic preparation of the present invention is an optimum organization, and for the feature of Herba Artemisiae annuae and Herba Viticis Cannabifoliae plant cell wall main component, design cellulase mass fraction 60-70%, pectase mass fraction is 15-25%, and all the other be xylanase, makes hydrolysis result the best.
Adopt the effective ingredient of pot group type dynamic countercurrent extraction to Herba Artemisiae annuae, Herba Viticis Cannabifoliae to extract, effectively shorten extraction time, improve the extraction ratio of effective ingredient.
In the leaching process of effective ingredient, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer, utilize pressure to change and make extraction ratio that is degerming, antipruritic, anophelifuge effective ingredient the highest.
The volume ratio of Herba Viticis Cannabifoliae and Herba Artemisiae annuae supernatant is 1:1-1:1.5 is optimum organization, and this combined degerming, antipruritic, repelling effect good, and supernatant has certain volatility, can play effect that is degerming, antipruritic, anophelifuge to greatest extent.
In sum, the present invention is by carrying out effective integration by above multinomial technology, and achieve with Herba Artemisiae annuae, Herba Viticis Cannabifoliae optimum efficiency that is degerming, antipruritic for primary raw material makes, mosquito-repellent perfume, the market competitiveness is strong, has a extensive future.
Detailed description of the invention
Below manufacture method that is degerming, antipruritic, mosquito-repellent perfume is described in detail.
embodiment 1:
(1) process of Herba Artemisiae annuae, Herba Viticis Cannabifoliae: Herba Artemisiae annuae and Herba Viticis Cannabifoliae are dried in the shade respectively, shred, the enzymolysis solution adding 5 times amount in the above-mentioned medical material handled well respectively enzymolysis 2.5 hours at the temperature of 45 degree.
Enzymolysis solution preparation method is: 7 grams of compound enzymic preparations to be dissolved in 500ml pH value be in the buffer of 5 and get final product.The proportioning of compound enzymic preparation is cellulase mass fraction 66%, and pectase mass fraction is 22%, and all the other are xylanase, and the average enzyme work of compound enzymic preparation is 28000 units.
(2) extraction and concentration of degerming, antipruritic, anophelifuge effective ingredient: the ethanol adding 92% in Herba Artemisiae annuae and Herba Viticis Cannabifoliae enzymolysis solution is respectively solvent, solvent carries out pot group type dynamic countercurrent extraction with the volume mass of raw medicinal material than for 16:1,4 hours extraction times, Extracting temperature 51 DEG C, extracting solution is evaporated to 4.1 times of raw materials quality after extraction completes, stand for standby use.
In said extracted process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer.
(3) making of floral water: get Herba Viticis Cannabifoliae and Herba Artemisiae annuae supernatant, volume ratio is 1:1.1, and mixing, adds 95% ethanol of 1/3rd cumulative volumes, and leave standstill clarification, clear liquor is floral water product.
embodiment 2:
(1) process of Herba Artemisiae annuae, Herba Viticis Cannabifoliae: Herba Artemisiae annuae and Herba Viticis Cannabifoliae are dried in the shade respectively, shred, the enzymolysis solution adding 7 times amount in the above-mentioned medical material handled well respectively enzymolysis 3.8 hours at the temperature of 49 degree.
Enzymolysis solution preparation method is: 12 grams of compound enzymic preparations to be dissolved in 500ml pH value be in the buffer of 6.1 and get final product.The proportioning of compound enzymic preparation is cellulase mass fraction 61%, and pectase mass fraction is 24%, and all the other are xylanase, and the average enzyme work of compound enzymic preparation is 21000 units.
(2) extraction and concentration of degerming, antipruritic, anophelifuge effective ingredient: the ethanol adding 94% in Herba Artemisiae annuae and Herba Viticis Cannabifoliae enzymolysis solution is respectively solvent, solvent carries out pot group type dynamic countercurrent extraction with the volume mass of raw medicinal material than for 19:1,7 hours extraction times, Extracting temperature 68 DEG C, extracting solution is evaporated to 3.2 times of raw materials quality after extraction completes, stand for standby use.
In said extracted process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer.
(3) making of floral water: get Herba Viticis Cannabifoliae and Herba Artemisiae annuae supernatant, volume ratio is 1:1.4, and mixing, adds 95% ethanol of 1/3rd cumulative volumes, and leave standstill clarification, clear liquor is floral water product.
Above-described embodiment not does any pro forma restriction to the present invention, any those of ordinary skill in the art, when not departing from technical solution of the present invention scope, the technology contents of above-mentioned announcement all can be utilized to make many possible variations and modification to technical solution of the present invention, or be revised as the Equivalent embodiments of equivalent variations.Therefore, every content not departing from technical solution of the present invention, according to the technology of the present invention essence to any simple modification made for any of the above embodiments, equivalent variations and modification, all should drop in the scope of technical solution of the present invention protection.
Claims (6)
1. a manufacture method for degerming, antipruritic, mosquito-repellent perfume, is characterized in that comprising following step:
(1) process of Herba Artemisiae annuae, Herba Viticis Cannabifoliae: Herba Artemisiae annuae and Herba Viticis Cannabifoliae are dried in the shade respectively, shred, adds enzymolysis solution enzymolysis 1-4 hour at the temperature of 40-50 degree of 2-8 times amount respectively in the above-mentioned medical material handled well;
(2) extraction and concentration of degerming, antipruritic, anophelifuge effective ingredient: the ethanol adding 90%-95% in Herba Artemisiae annuae and Herba Viticis Cannabifoliae enzymolysis solution is respectively solvent, solvent is 15:1-20:1 with the volume mass ratio of raw medicinal material, carry out pot group type dynamic countercurrent extraction, extraction time 3-8 hour, Extracting temperature 50-70 DEG C, extracting solution is evaporated to 3-5 times of raw materials quality after extraction completes, leaves standstill standby;
(3) making of floral water: get Herba Viticis Cannabifoliae and Herba Artemisiae annuae supernatant, volume ratio is 1:1-1:1.5, and mixing, adds 95% ethanol of 1/3rd cumulative volumes, and leave standstill clarification, clear liquor is floral water product.
2. the manufacture method of degerming, antipruritic, mosquito-repellent perfume according to claim 1, is characterized in that: described enzymolysis solution preparation method is that 1-15 gram of compound enzymic preparation is dissolved in 500ml pH value is in the buffer of 4-7 and get final product.
3. the manufacture method of degerming, antipruritic, mosquito-repellent perfume according to claim 2, is characterized in that: the proportioning of described compound enzymic preparation is cellulase mass fraction 60-70%, and pectase mass fraction 15-25%, all the other are xylanase.
4. the manufacture method of degerming, antipruritic, mosquito-repellent perfume according to claim 2, is characterized in that: the average enzyme of described compound enzymic preparation is lived as 20000-30000 unit.
5. the manufacture method of degerming, antipruritic according to claim 1 or 2 or 3 or 4, mosquito-repellent perfume, is characterized in that: carry out step evacuation and vacuum breaker to extraction pot in extracts active ingredients process.
6. degerming, antipruritic, the mosquito-repellent perfume that method obtains according to claim 1 or 2 or 3 or 4.
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| CN201510189971.XA CN104739730A (en) | 2015-04-21 | 2015-04-21 | Preparation method for degerming, itching-relieving and mosquito-repelling floral water |
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Cited By (3)
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| CN107260593A (en) * | 2017-05-27 | 2017-10-20 | 江西科技师范大学 | Compound pair of wormwood artemisia mosquito repellent liquid and preparation method thereof of external application |
| KR20180076472A (en) * | 2016-12-28 | 2018-07-06 | 농업회사법인 주식회사 씨비엠씨 | Mosquito repellent using vitex limonifolia extracts |
| CN108650881A (en) * | 2016-01-29 | 2018-10-12 | 科学发展实验室 | Dermatology or cosmetic composition containing the five-leaved chaste tree extract rich in polyphenol |
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| CN102357066A (en) * | 2011-10-26 | 2012-02-22 | 天津郁美净集团有限公司 | Cortex phellodendri extract and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108650881A (en) * | 2016-01-29 | 2018-10-12 | 科学发展实验室 | Dermatology or cosmetic composition containing the five-leaved chaste tree extract rich in polyphenol |
| KR20180076472A (en) * | 2016-12-28 | 2018-07-06 | 농업회사법인 주식회사 씨비엠씨 | Mosquito repellent using vitex limonifolia extracts |
| KR101933599B1 (en) * | 2016-12-28 | 2018-12-28 | 농업회사법인 주식회사 씨비엠씨 | Mosquito repellent using vitex limonifolia extracts |
| CN107260593A (en) * | 2017-05-27 | 2017-10-20 | 江西科技师范大学 | Compound pair of wormwood artemisia mosquito repellent liquid and preparation method thereof of external application |
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