CN104739377A - Device, system and method for simultaneously carrying out OCT imaging and pressure measurement in blood vessel - Google Patents
Device, system and method for simultaneously carrying out OCT imaging and pressure measurement in blood vessel Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02141—Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
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Abstract
The invention discloses a device, system and method for simultaneously carrying out OCT imaging and pressure measurement in a blood vessel. The device comprises an imaging and pressure measurement catheter and a driving control mechanism, wherein the imaging and pressure measurement catheter comprises a catheter optical fiber and an optical fiber probe which are connected, a transmission shaft is arranged outside the catheter optical fiber, an optical fiber end surface of the optical fiber probe is provided with a spherical lens and a light-permeable element, and a pressure sensor is arranged at an end of the optical fiber probe; the driving control mechanism comprises a rotary control unit and a retracement unit, and the rotary control unit is connected with the catheter optical fiber and an external optical fiber and controls the transmission shaft to drive the optical fiber probe to rotate; the retracement unit controls the optical fiber probe to move in the radial direction of the blood vessel through the transmission shaft. The device, system and method for simultaneously carrying out OCT imaging and pressure measurement in the blood vessel can measure blood vessel inner wall morphology images and pressure in the blood vessel in the same catheter.
Description
Technical field
The present invention relates to cardiovascular detection field, particularly relate to a kind of Ink vessel transfusing and carry out OCT imaging and pressure gauge, system and method simultaneously.
Background technology
Coronary artery disease (CAD) is that the whole world causes dead No.1 reason.Due to atheromatous plaque accumulation, break and thrombosis, coronary artery disease (CAD) can cause chest pain (angina pectoris), myocardial ischemia and sudden cardiac death.Do not die suddenly for those or have the patient of chronic angina symptom, the treatment of suitable speckle comprises percutaneous coronary intervene operation (PCI).Cardiac interventional expert to be performed the operation placing rack process pathological changes by PCI, but many results of study think that cardiac stent is abused in recent years, or at least excessively uses and cause a lot of dispute, and doctor is more careful and fastidious when considering a use support.In addition because lower-cost Drug therapy is introduced in market, research finds that they are also effective.When treating the patients with coronary heart disease of stable disease, we have seen the gentleness decline of stent endoprosthesis.These factors, add increasing public suggestion, three kinds of new blood vessel imaging/measurement devices and consumptive material: 1) intravascular ultrasound (IVUS), 2) optical coherence tomography (OCT) and 3) blood flow reserve mark (FFR) technology can help doctor to be that each patient's preoperative evaluation whether insert and postoperative evaluation by support exactly, plays more and more important effect in coronary disease lesion examining.
A large amount of clinical data shows, intravascular pressure is measured very important for coronary intervention procedure, the most frequently used metering system blood flow reserve mark (Fractional Flow Reserve, FFR) impact of narrow arteria coronaria for heart muscle perfusion has been reacted, be considered to the goldstandard evaluating the arteria coronaria order of severity in intrusive mood detection mode, therefore updated Guidelines is recommended, and may cause the stenotic lesion of ischemia for those, and application FFR evaluates angiostenosis degree and is proposed as I class evidence.FFR uses the seal wire of band pressure transducer to be inserted into tremulous pulse, and seal wire end to investigated lesion is measured.Be generally induce maximum hyperemia (most high blood flow) by the intravascular administration of adenosine, carry out pressure measxurement with Pressure wire far-end to narrow and divided by aortal pressure, record FFR value simultaneously.FFR parameter at present for clinical practice to determine whether that the patient of coronary artery pathological changes should use support to treat.
Although FFR technology has been proved to be valuable intervention diagnosis measurement means, in many situations, FFR can not be used for separately instructing intervene operation: 1) tonometric anthropic factor sometimes can provide the order of severity that FFR value might not indicate vascular lesion; 2) due to faulty certainty of measurement, connect the FFR value near subject boundary may give get involved expert bring challenges; 3) in many cases, blood vessel blockage is the grumeleuse coming from diseased region, and FFR is not the true measurement of lesion degree in these cases; 4) FFR does not provide any information to arterial wall itself, therefore can not be used to optimize the type or length that need to be placed support.
The reason do not enumerated because above and other, Cardiac interventional expert needs the information obtained about coronary artery wall construction to carry out guidance of interventional treatment to provide more data.
Optical coherence tomography (Optical Coherence Tomography, OCT) is exactly such high-resolution (10 micron order) angioarchitecture imaging technique.In intracardiac OCT, conduit is inserted into tremulous pulse with the resolution section and the 3-D view that obtain 10 microns, makes the visual of the detailed micro-structural feature of arterial blood tube wall become possibility.The various relevant Clinical symptoms such as intracardiac OCT has been proved to be able to distinguish the existence comprising lipid, inflammation, calcification, grumeleuse (thrombosis).OCT effectively can describe degree and the type of culprit vessel pathological changes in these information that three dimensions catches, thus is used to Guided Interventional Treatment program as significant data.OCT also can be used in the non-Culprit fart that imaging not yet causes thrombosis in addition.The non-Culprit fart for the treatment of before these coronary vasodilator pathological changes occur is a kind of promising, for improving the concept of CAD incidence and mortality.
FFR and OCT technology are widely accepted by doctor all, but OCT conduit and FFR seal wire separately use as individual equipment at present, so add the persistent period of inspection, complexity, and patient's use cost.
Summary of the invention
Goal of the invention of the present invention is to set up one can complete microcosmic Imaging Study to vascular tissue and endovascular tonometric device simultaneously.
The technical solution adopted for the present invention to solve the technical problems is:
There is provided a kind of Ink vessel transfusing to carry out OCT imaging and pressure gauge simultaneously, comprise imaging pressure catheter and drived control mechanism, wherein:
Imaging pressure catheter comprises the catheter fiber and fibre-optical probe that are connected, and described catheter fiber outside is provided with power transmission shaft; The fiber end face of described fibre-optical probe is provided with globe lens and light penetrating device, and the end of this fibre-optical probe is provided with pressure transducer; Enter a part of optical signal directive blood vessel wall after globe lens refraction of catheter fiber, former road returns after reflection, obtains the reflection OCT light beam comprising blood vessel wall topographical information; Another part optical signal, by light penetrating device directive pressure transducer, returns along former road after reflection, obtains the reflected pressure light beam comprising blood stream pressure information; Described reflection OCT light beam and described reflected pressure light beam are all transferred out by described catheter fiber;
Drived control mechanism, comprises rotation control unit and withdraws unit, described rotation control unit connecting duct optical fiber and external fiber, and controls the rotation of power transmission shaft drive fibre-optical probe; The described unit controls that withdraws is moved radially along blood vessel by power transmission shaft control fibre-optical probe.
In device of the present invention, the outside of described fibre-optical probe is provided with sleeve pipe.
In device of the present invention, described power transmission shaft outside is provided with protective sleeve.
In device of the present invention, this imaging pressure catheter also comprises transparent casing, with described protective sleeve and to be describedly telescopic jointly integrated.
In device of the present invention, described protective sleeve is rigid protective cover.
In device of the present invention, the diameter of described imaging pressure catheter is not more than 550 microns.
In device of the present invention, described pressure transducer is interferometer, fiber grating or deformable film.
Present invention also offers a kind of Ink vessel transfusing and carry out OCT imaging and pressure-measuring system simultaneously, comprise frequency swept laser, beam splitter, delay line, polariser, optical circulators, splicer, coherent optical receiver, signal processing module, image workstation terminal and Ink vessel transfusing and carry out OCT imaging and pressure gauge simultaneously, the drived control mechanism in this device is connected with optical circulators by optical fiber;
Image workstation terminal control frequency swept laser produces sweeping laser signal, and be divided into two parts through beam splitter, a part of delayed line, polariser obtain standard laser signal and enter splicer, and another part light enters measuring device through optical circulators; The reflection OCT light beam obtained by measuring device and reflected pressure light beam are after optical circulator, converge to splicer with standard laser signal and produce interference signal, interference signal is received by coherent optical receiver and converts the signal of telecommunication to, the signal of telecommunication is through amplifying and passing to signal processing module, finally at image workstation terminal demonstration after digital-to-analogue conversion.
Present invention also offers a kind of Ink vessel transfusing and carry out OCT imaging and pressure measurement method simultaneously, comprise the following steps:
Frequency swept laser produces sweeping laser signal, and be divided into two parts through beam splitter, a part of delayed line, polariser obtain standard laser signal;
Another part light enters measuring device through optical circulators, controlling power transmission shaft by the rotation control unit in drived control mechanism drives catheter fiber to rotate, make can carry out 360 degree of scannings at the incident optical signal of fibre-optical probe at Ink vessel transfusing, and correspondingly receive the optical signal reflected by blood vessel wall and pressure transducer;
When fibre-optical probe is after Ink vessel transfusing certain completes 360 degree of rotations, driving fibre-optical probe to be radially moved into next sample point along blood vessel by withdrawing unit, completing 360 degree of scannings once again, by that analogy, obtaining the optical signal reflected in one section of blood vessel;
Optical signal and the standard laser signal of reflection converge generation interference signal, convert interference signal to the signal of telecommunication, and the signal of telecommunication obtains blood vessel transverse section pattern complete in the blood vessel of one end and pressure data through amplifying with the laggard row relax of digital-to-analogue conversion, and shows.
The beneficial effect that the present invention produces is: the present invention arranges globe lens and light penetrating device on fibre-optical probe, globe lens reflection OCT light beam is used to be used for OCT imaging, use globe lens and light penetrating device separating pressure light beam to pressure transducer, thus in same conduit, realize the dual purpose of the measurement to blood vessel feature image and intravascular pressure.
Further, imaging pressure catheter diameter of the present invention is not more than 550 microns, therefore can not change the hemodynamics of 2mm arteria coronaria, thus accurately can measure this kind of endovascular pressure.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the invention will be further described, in accompanying drawing:
Fig. 1 is the structural representation that embodiment of the present invention Ink vessel transfusing carries out OCT imaging and pressure gauge simultaneously;
Fig. 2 is the structural representation of embodiment of the present invention imaging pressure catheter;
Fig. 3 is the structural representation that embodiment of the present invention Ink vessel transfusing carries out OCT imaging and pressure-measuring system simultaneously.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
As shown in Figure 1, the Ink vessel transfusing of the embodiment of the present invention carries out OCT imaging simultaneously and pressure gauge 10 comprises imaging pressure catheter and drived control mechanism, and both connect by opto-mechanical mechanisms.
Imaging pressure catheter comprises the catheter fiber 14 and fibre-optical probe 16 that are connected, and catheter fiber 14 outside is provided with power transmission shaft 15; As shown in Figure 2, the fiber end face of fibre-optical probe 16 is provided with globe lens 162 and light penetrating device 163, and the central role of this light penetrating device 163 is effectively transmit transillumination and reflected light, and this light penetrating device 163 can select prism or gradual index lens.The end of this fibre-optical probe 16 is provided with pressure transducer 161; Enter a part of optical signal directive blood vessel wall 18 after globe lens 162 reflects of catheter fiber 14, former road returns after reflection, obtains the reflection OCT light beam comprising blood vessel wall topographical information; Another part optical signal, by light penetrating device 163 directive pressure transducer 161, returns along former road after reflection, obtains the reflected pressure light beam comprising blood stream pressure information; Reflection OCT light beam and reflected pressure light beam are all transferred out by catheter fiber 14.Visible, use identical light source for tonometric pressure light beam with for generation of the OCT light beam of OCT image in the embodiment of the present invention.
Drived control mechanism, comprises rotation control unit 12 and withdraws unit 13, rotation control unit 12 connecting duct optical fiber 14 and external fiber 11, and controls power transmission shaft 15 and drive fibre-optical probe 16 to rotate; Withdraw unit 13 to control to control fibre-optical probe 16 by power transmission shaft 15 and move radially along blood vessel.
The core of catheter fiber 14 is fiber cores, and it is the optical channel of light signal transduction, and the one deck outside fibre core is the fibre cladding of refractive index lower than fiber cores refractive index, to form good fiber waveguide; Tight optical fiber transmission shaft tube on cover outside fibre cladding, makes optical fiber also can controlled rotation.In one embodiment of the present of invention, can be provided with protective sleeve in power transmission shaft outside, protective sleeve is rustless steel or other rigid protective covers.
In one embodiment of the present of invention, the outside of fibre-optical probe 16 is provided with sleeve pipe 19.
In one embodiment of the present of invention, this imaging pressure catheter also comprises transparent casing 17, and Main Function is the protection of optical fiber and the optical information of printing opacity detection blood vessel wall, is arranged on the outside of protective sleeve and sleeve pipe 19.
Laser signal enters catheter fiber 14 by optical fiber 11 through opto-mechanical mechanisms.Rotation control unit 12 and withdraw the power transmission shaft 15 that unit 13 controls in catheter fiber 14 and drive fiber spinning, makes the incident optical signal at fibre-optical probe 16 can carry out 360 degree of scannings at Ink vessel transfusing and correspondingly receive the optical signal reflected by blood vessel wall 18 and pressure transducer 161.360 degree of rotation sweeps can obtain complete blood vessel transverse section pattern and pressure data.When fibre-optical probe 16 complete 360 degree rotate and obtain the complete blood vessel wall cross-sectional morphology in certain after, withdrawing unit 13 drives fibre-optical probe 16 to be radially moved into next sample point along blood vessel, completes 360 degree of scannings once again and obtains complete blood vessel wall transverse section pattern and pressure data herein.By that analogy, catheter fiber 14 can complete the pattern and pressure data that one section of blood vessel is radial and transverse section is complete.Fibre-optical probe 16 carries out precision machined one group of optical prism lens combination.Corresponding pressure sensor device is also provided with in addition in fibre-optical probe 16 part.The diameter of whole catheter fiber of the present invention is not more than 550 microns, be applicable in the coronary artery of 2mm ~ 3.5mm, similar catheter fiber diameter commercial in the market is all greater than 800 microns, is enough to the hemodynamics changing 2mm arteria coronaria, thus accurately can not measures this kind of endovascular pressure.
As shown in Figure 3, for embodiment of the present invention Ink vessel transfusing carries out the structural representation of OCT imaging and pressure-measuring system simultaneously, comprise frequency swept laser 21, beam splitter 22, delay line and polariser 23, optical circulators 24, splicer 25, coherent optical receiver 26, signal processing module 27, image workstation terminal 28 and above-described embodiment Ink vessel transfusing carry out OCT imaging and pressure gauge 10 simultaneously, the drived control mechanism in this device 10 is connected with optical circulators 24 by optical fiber 11.
Image workstation terminal 28 controls frequency swept laser 21 and produces sweeping laser signal, two parts are divided into through beam splitter 22, the delayed line of a part and polariser 23 obtain standard laser signal and enter splicer 25, and another part light enters measuring device 10 through optical circulators 24; The reflection OCT light beam obtained by measuring device 10 and reflected pressure light beam after optical circulator 24, import delay line into and polariser 23 is resent to the image information of receiving terminal acquisition blood vessel wall and endovascular pressure information, namely converge to splicer 25 with standard laser signal and produce interference signal, interference signal is received by coherent optical receiver 26 and converts the signal of telecommunication to, the signal of telecommunication is through amplifying and passing to signal processing module 27 after digital-to-analogue conversion, finally show in image workstation terminal 28, finally complete the measurement to blood vessel feature image and intravascular pressure.
As shown in Figure 2, the fiber end face of the fibre-optical probe 16 of the embodiment of the present invention have employed the combination of globe lens and light penetrating device, flashlight is through globe lens 162, and part is refracted (being defined as OCT light beam), and part is transmitted (being defined as pressure light beam).OCT light beam directive blood vessel wall, at this moment the OCT light beam comprising blood vessel wall topographical information is reflected back globe lens 162 by blood vessel wall, the optical circulators 24 in Fig. 3 is gone back on former road, then imports delay line and polariser 23 into and be resent to receiving terminal and obtain the image information of blood vessel wall and endovascular pressure information.Pressure light beam is by after globe lens 162 transmission, through light penetrating device 163 directive pressure transducer 161, (pressure transducer 161 can be interferometer in continuation, fiber-optic grating sensor or deformable membrane etc.), pressure transducer 161 in embodiment of the present invention Fig. 1 is one deck deformable film, deformable film experiences Ink vessel transfusing blood stream pressure, and reflected pressure light beam, at this moment the reflected pressure light beam containing blood stream pressure information turns back to light penetrating device 163 and globe lens 162 by former road, join with by the OCT light beam reflected, the optical circulators 24 in Fig. 3 is gone back on former road, finally reach the dual purpose of the measurement to blood vessel feature image and intravascular pressure.
In the system of the present invention, the wavelength of light is continuously adjustable, and the vascular tissue that the light of different wave length enters different depth produces different reflected light, converges the different interference signal of video signal of rear generation from the light of standard laser signal.Reflectance as the function of tissue depth by converting out to the Fourier transformation of spectrum interference signal.The vascular wall tissue grade degree of depth can be obtained like this, and the contour image of 10 micrometer resolution.
Based on the system of above-described embodiment, Ink vessel transfusing of the present invention carries out OCT imaging and pressure measurement method simultaneously, mainly comprises the following steps:
Frequency swept laser produces sweeping laser signal, and be divided into two parts through beam splitter, a part of delayed line and polariser obtain standard laser signal;
Another part light enters measuring device through optical circulators, controlling power transmission shaft by the rotation control unit in drived control mechanism drives catheter fiber to rotate, make can carry out 360 degree of scannings at the incident optical signal of fibre-optical probe at Ink vessel transfusing, and correspondingly receive the optical signal reflected by blood vessel wall and pressure transducer;
When fibre-optical probe is after Ink vessel transfusing certain completes 360 degree of rotations, driving fibre-optical probe to be radially moved into next sample point along blood vessel by withdrawing unit, completing 360 degree of scannings once again, by that analogy, obtaining the optical signal reflected in one section of blood vessel;
Optical signal and the standard laser signal of reflection converge generation interference signal, convert interference signal to the signal of telecommunication, and the signal of telecommunication obtains blood vessel transverse section pattern complete in the blood vessel of one end and pressure data through amplifying with the laggard row relax of digital-to-analogue conversion, and shows.
Should be understood that, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection domain that all should belong to claims of the present invention.
Claims (10)
1. Ink vessel transfusing carries out OCT imaging and a pressure gauge simultaneously, it is characterized in that, comprises imaging pressure catheter and drived control mechanism, wherein:
Imaging pressure catheter comprises the catheter fiber and fibre-optical probe that are connected, and described catheter fiber outside is provided with power transmission shaft; The fiber end face of described fibre-optical probe is provided with globe lens and light penetrating device, and the end of this fibre-optical probe is provided with pressure transducer; Enter a part of optical signal directive blood vessel wall after globe lens refraction of catheter fiber, former road returns after reflection, obtains the reflection OCT light beam comprising blood vessel wall topographical information; Another part optical signal, by light penetrating device directive pressure transducer, returns along former road after reflection, obtains the reflected pressure light beam comprising blood stream pressure information; Described reflection OCT light beam and described reflected pressure light beam are all transferred out by described catheter fiber;
Drived control mechanism, comprises rotation control unit and withdraws unit, described rotation control unit connecting duct optical fiber and external fiber, and controls the rotation of power transmission shaft drive fibre-optical probe; The described unit controls that withdraws is moved radially along blood vessel by power transmission shaft control fibre-optical probe.
2. device according to claim 1, is characterized in that, the outside of described fibre-optical probe is provided with sleeve pipe.
3. device according to claim 1, is characterized in that, described power transmission shaft outside is provided with protective sleeve.
4. device according to claim 3, is characterized in that, this imaging pressure catheter also comprises transparent casing, with described protective sleeve and to be describedly telescopic jointly integrated.
5. device according to claim 3, is characterized in that, described protective sleeve is rigid protective cover.
6. device according to claim 1, is characterized in that, the diameter of described imaging pressure catheter is not more than 550 microns.
7. device according to claim 1, is characterized in that, described pressure transducer is interferometer, fiber grating or deformable film.
8. device according to claim 1, is characterized in that, described light penetrating device is prism or gradual index lens.
9. an Ink vessel transfusing carries out OCT imaging and pressure-measuring system simultaneously, it is characterized in that, comprise frequency swept laser, beam splitter, delay line, polariser, optical circulators, splicer, coherent optical receiver, signal processing module, image workstation terminal and the Ink vessel transfusing according to any one of claim 1-7 and carry out OCT imaging and pressure gauge simultaneously, the drived control mechanism in this device is connected with optical circulators by optical fiber;
Image workstation terminal control frequency swept laser produces sweeping laser signal, and be divided into two parts through beam splitter, a part of delayed line, polariser obtain standard laser signal and enter splicer, and another part light enters measuring device through optical circulators; The reflection OCT light beam obtained by measuring device and reflected pressure light beam are after optical circulator, converge to splicer with standard laser signal and produce interference signal, interference signal is received by coherent optical receiver and converts the signal of telecommunication to, the signal of telecommunication is through amplifying and passing to signal processing module, finally at image workstation terminal demonstration after digital-to-analogue conversion.
10. the Ink vessel transfusing based on claim 8 carries out OCT imaging and a pressure measurement method simultaneously, it is characterized in that, comprises the following steps:
Frequency swept laser produces sweeping laser signal, and be divided into two parts through beam splitter, a part of delayed line, polariser obtain standard laser signal;
Another part light enters measuring device through optical circulators, controlling power transmission shaft by the rotation control unit in drived control mechanism drives catheter fiber to rotate, make can carry out 360 degree of scannings at the incident optical signal of fibre-optical probe at Ink vessel transfusing, and correspondingly receive the optical signal reflected by blood vessel wall and pressure transducer;
When fibre-optical probe is after Ink vessel transfusing certain completes 360 degree of rotations, driving fibre-optical probe to be radially moved into next sample point along blood vessel by withdrawing unit, completing 360 degree of scannings once again, by that analogy, obtaining the optical signal reflected in one section of blood vessel;
Optical signal and the standard laser signal of reflection converge generation interference signal, convert interference signal to the signal of telecommunication, and the signal of telecommunication obtains blood vessel transverse section pattern complete in the blood vessel of one end and pressure data through amplifying with the laggard row relax of digital-to-analogue conversion, and shows.
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| CN105054901A (en) * | 2015-08-26 | 2015-11-18 | 张文保 | Single-optical-fiber endoscope system integrated with optical coherence tomography and fractional flow reserve detection |
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| CN113876357A (en) * | 2020-11-04 | 2022-01-04 | 科特有限责任公司 | Imaging and pressure sensing device and probe with slidable sleeve |
| WO2022007794A1 (en) * | 2020-07-10 | 2022-01-13 | 阮渊 | Optical fiber guide wire for monitoring intravascular pressure, and intravascular pressure measurement device |
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