A kind of binocular pupil is to light comprehensive detection system
Technical field
The invention belongs to field of visual inspection, it is specifically related to a kind of binocular pupil to light comprehensive detection system, including thermal camera, infrared illumination source, stimulating light source, grasping type device, measure display device, Single-chip Controlling, data processing and control module and pupil tracing measurement system module, be suitable for the medical applications of Clinical Ophthalmology, neurosurgery, psychiatric section and association area thereof.
Background technology
When human eye is subject to photostimulation, contracted pupil, it is called pupillary light reflex.Shrinking of pupil is completed by the sphincter pupillae of the parasympathetic innervation in the dynamic nerve of eye, and the expansion of pupil is completed by the dilator pupillae of sympathetic innervation, and both restrict each other maincenter is mutually coordinated, thus realizing the pupillary light reflex control of complexity.The reflection of homonymy claims direct light reflex, and offside contracted pupil claims consensual reflex.Central regulation damages will cause that luminous reflectance weakens or disappears.
The diameter of normal pupil is 2.5-4.5 millimeter, rounded, and both sides pupil waits greatly substantially, and difference is usually no more than 0.5 millimeter, and luminous reflectance is sensitive.Everyone pupil size is affected by factors such as age, physiological status, dioptric, external environments, in different size.Pupil diameter is as being abnormal more than 6 millimeters or less than 2 millimeters;Both sides anisocoria, especially blunt with light emission or disappear time be pathologic.In normal person, child's pupil is relatively big, and old man is less.Contracted pupil in bed, becomes again big, for physiological phenomenon after waking up.Contracted pupil can be caused when some drugs is poisoning, such as organophosphor, barbital Lou, the derivant etc. of morphine and Opium poisoning.Some mental symptom, as anxiety, terrified, pain etc. can cause platycoria;Atropine, cocaine and creotoxin are poisoning etc. also can cause platycoria;The shape of pupil, size and luminous reflectance can be affected, such as the pathological changes such as cornea, iris during eye local patholoic change.Therefore clinically according to above-mentioned characteristic, pupillary light reflex equipment is used to carry out examination relevant disease in Clinical Ophthalmology, neurosurgery, psychiatric section even treating narcotic addiction field.
With assembling light during pupillary light reflex equipment inspection, irradiate in the middle of being directed at two, observe luminous reflectance, light source being shifted to bilateral pupil central authorities more respectively, observes directly reflection and the indirect light reflex of pupil, pupil is under light illumination, cause aperture to diminish, be called direct light reflex.Such as another eye of illumination, the pupil of non-illumination eye causes and reduces, and is called indirect light reflex.Directly or indirectly reflect and all disappear, see deep coma or homonymy oculomotorius is impaired;Direct light reflex disappears, and indirect light reflex exists, and sees ION impaired;Therefore optical reflectance measurements is necessary by binocular.
Pupillary light reflex has incubation period, namely starts the interval reaction from beginning photostimulation to pupil.Coma patient performance is blunt, and incubation period is longer, and stimulates sensitive time too short, and pupillary light reflex phenomenon is inconspicuous, therefore needs to extend light stimulation time for degree of depth coma patient.
Tradition pupil detection mode mainly has electroretinogram, visual evoked potential and electro-oculogram etc.;Pupillometer is mainly totally enclosed type inspection box;Portable inspection equipment mainly has hand-held pupil lamp, pocket lamp etc..Having drawbacks in that of existing inspection equipment and method
(1) measure content, precision limited: hand-held pupil lamp, pocket lamp etc. cannot to the size of pupil and luminous reflectance situation is objective, measure quantitatively, accurately, including cannot to the measurement of luminous reflectance incubation period, pupil contraction speed etc.;
(2) portability is poor: instrument for examining pupil equipment volume is relatively big, relatively heavy, and needs to be placed on smooth environment, is not suitable for using in the wild;
(3) detection object is limited: existing equipment, and stimulating light source stimulation time is fixed, it is impossible to check disease for special sufferer, such as severe coma patient;
(4) operation is not convenient, be subject to interference caused by subjective factors: traditional instrument for examining pupil equipment, a lot of test links need artificial participation, it is inaccurate that manually-operated diversity and subjective judgment can result in test, and requires that the fitness of experimenter is significantly high, can bring sticky feeling to experimenter;
(5) poor real: the collected by camera frame frequency of existing pupil detection equipment is relatively low, pupillometry software poor real, therefore certainty of measurement is limited;
(6) operating efficiency is limited: binocular pupillary light reflex inspection do not supported by existing portable equipment, it is impossible to the patient that examination indirect light reflex is abnormal;
(7) measurement result is not directly perceived: existing pupillary light reflex equipment provides measurement result parameter, without change curve intuitively.
For the disadvantages mentioned above of legacy equipment, inventors have devised that a kind of binocular pupillary light reflex follows the tracks of system.
Summary of the invention
For overcoming deficiency of the prior art, the present invention have developed a kind of binocular pupil to light comprehensive detection system, including thermal camera, infrared illumination source, stimulating light source, grip device, display device, single-chip data processing and control module and pupil tracing measurement module.The stimulating light source temporal mode of this equipment is adjustable, supports binocular pupillometry, and portable devices is strong, and it is high that pupil tracing measures system algorithm precision, real-time, improves device measuring precision.
Wherein, thermal camera, light source and single-chip data processing module are integrated in inside grasping type device, and display module is installed on outside grasping type device;Pupil tracing measurement module is applied to single-chip data processing module, single-chip microcomputer obtain camera image input, pupil tracing measurement module tracing computation, and single-chip microcomputer is exported to display screen or other terminal by wireless WIFI or bluetooth;Infrared illumination source, stimulating light source by single-chip microcomputer processing controls, i.e. button on grasping type device by grasping type device, can be passed through the button on grasping type device, select the different source stimulating time to measure;
Wherein, the software of pupil tracing measurement module is by designing multiple step format region adaptivity sub-pix track algorithm, while improving pupil tracking accuracy, also the following calculation algorithm time is made to be reduced to original 1/20 even lower, greatly improve the time resolution of pupil tracking process, it is possible to the better current demand meeting clinical high-precision high-speed pupil tracing.Concrete grammar is the intensity profile for eye image and noise behavior, propose the automatic threshold segmentation algorithm based on human eye pupil gray feature, achieve the intercepting of the coarse positioning to pupil center and pupil region, it is to avoid the impact of the chaff interferences such as hot spot, eyelash, eyelid.According to the result after coarse positioning, removing the bright spot that pupil intraoral illumination light source produces, automatic threshold calculates again, judge to calculate pupil barycenter, quickly limit next frame pupil position and pupil region according to this centroid position, accelerate detection speed, it is achieved the real-time positioning of pupil is followed the trail of.The Measurement Algorithm real-time that pupil tracing measures system is high, captures continuous print pupil image, and collecting sample is many, it is achieved that high-precision pupil tracing detects.
It addition, the analysis of data collected measurement result according to different stimulated when, design analytical plan, test according to test experiments and clinical practice, analyze the standard reference frame obtaining a set of pupillary light reflex parameter, and export diagnosis report.Body can be directly displayed at and carry on display screen, it is also possible to stored by data, compress technique completes the mutual of portable or wearable device and terminal by the Radio Transmission Technology such as bluetooth, ZigBee, Wifi and wired connection mode.
The measurement system of the present invention provides the benefit that:
(1) grasping type or Wearable device portability are strong, can be applicable to the occasion that the natural conditions such as first aid, ward, even field are poor;
(2) measurement result accurately, intuitively, can promptly show on a display screen;
(3) grasping type handle is detachable, and equipment body as the core component of Wearable device, can individually be fixed on operating board or be fixed on experimenter;
(4) support binocular pupillometry, directly or indirectly pupillary light reflex measurement result can be obtained;
(5) equipment flexibility ratio is high, supports wirelessly or non-wirelessly by measurement result output data terminal, meets measurement result memory requirement;
(6) stability of measurement result is high, and grasping type or Wearable structure ensure that equipment is stable with eyes phase position, it is ensured that pupil image quality and measurement result precision;
(7) photic stimulator of measurement device stimulates spectrum, stimulus intensity, stimulus waveform and stimulation time on-demand to arrange, and meets the demand of clinical multiple indication and special environment;
(8) pupil tracing Survey Software algorithm adopts multiple step format region adaptivity sub-pix tracking, and tracking accuracy is high, when equal calculated performance, is effectively improved pupil tracking frame per second and tracking accuracy;
(9) measurement device includes display device, not only shows pupil image, measurement result parameter, additionally provides pupil change curve intuitively, it is simple to operator's observation analysis;
(10) software system is by test experiments and clinical practice test, it is provided that the standard reference frame of a set of pupillary light reflex parameter.
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention, and can be practiced according to the content of description, below with presently preferred embodiments of the present invention and coordinate accompanying drawing describe in detail as after.The specific embodiment of the present invention is shown in detail in by following example and accompanying drawing thereof.The part making improvement is only described by many places of the present invention, and other undeclared parts can realize by the state of the art, that is undeclared part is by existing techniques in realizing, is not described in detail at this.
Accompanying drawing explanation
Accompanying drawing described herein is used for providing a further understanding of the present invention, constitutes the part of the application, and the schematic description and description of the present invention is used for explaining the present invention, is not intended that inappropriate limitation of the present invention.In the accompanying drawings:
Fig. 1 is the system structure schematic diagram of the present invention.
Fig. 2 is the surface structure schematic diagram of the present invention.
Fig. 3 is the pupil tracing measurement module structural representation of the present invention.
Description of reference numerals:
1: shift knob;2: stimulating light source knob;3: pupil tracing button;4: display screen;5: grasping type device;6,7: by location;8,9: soft bumper ring;10: single-chip microcomputer;11: power supply;12,13: infrared camera;14,15: infrared illumination source;16,17: stimulating light source.
Detailed description of the invention
Below in conjunction with drawings and Examples, the technology implementation process of the present invention is described further.
Embodiment 1:
This example demonstrates that the system architecture of the present invention.
In conjunction with accompanying drawing 1, it is the system structure schematic diagram of the present invention, and system includes grasping type binocular pupil detection apparatus imaging system and pupil tracing measurement module.Wherein, imaging system comprises two infrared cameras, two infrared illumination source, two stimulating light sources, grasping type equipment and single-chip microcomputer, infrared camera, lighting source, stimulating light source, single-chip microcomputer are integrated in grasping type device interior, camera and light source are connected with single-chip microcomputer, single-chip microcomputer be responsible for the control of signal and the input and output of data;Pupil tracing measurement module is integrated in single-chip microcomputer, is tracked measuring to the image of single-chip microcomputer collection, and is analyzed measurement result processing, and is finally carrying display on screen, it is possible to exported to terminal by wireless (such as WIFI, bluetooth) or wired connection.
Lighting source within grasping type binocular pupil detection apparatus imaging system can be near infrared illumination source, and near infrared illumination source, by Single-chip Controlling, provides stable lighting environment for imaging;The spectrum of stimulating light source, brightness, stimulation time can arrange change by system, as: stimulating light source selects green glow, brightness 1000mcd, stimulation time 400ms;
Measurement result display device is embedded on grasping type device, supports the display of pupil image and measurement result.
Pupil tracing measurement module supports the output of data and the output of measurement report, by result output to other terminal, in order to further store analysis.
In conjunction with accompanying drawing 1, extraneous control inputs and record storage, report generation etc., also can be completed by the computer with memorizer.
Embodiment 2:
The present embodiment carries out on the basis of aforesaid embodiment 1, with previous embodiment 1 the difference is that, the surface structure of present system is described in detail by the present embodiment.
In conjunction with accompanying drawing 2, it is a kind of surface structure schematic diagram of the present invention, includes front view, rearview (Fig. 2 a) and top view (Fig. 2 b) respectively.
The present invention is a kind of grasping type measurement device, includes infrared camera 12,13 in grasping type equipment, and two cameras are each independently directly controlled by single-chip microcomputer, are respectively completed image acquisition, and are finally connected with pupil tracing measurement module;In conjunction with accompanying drawing 2a, grasping type equipment top is measurement portion, and bottom is handle.
In equipment, installation infrared lighting source 14,15, are opened by Single-chip Controlling, are arranged on the side of camera, the front of eyes, it is ensured that the bright spot that infrared illumination source is formed at inside ofeye drops on inside pupil, in order to avoid affecting pupillometry precision;
Installing stimulating light source 16,17 in equipment, stimulating light source is arranged on the opposite side of camera, just to eyes, by the stimulation time of the button control opening and closing on pupil tracing measurement module or equipment and stimulating light source.
The measurement portion of equipment is arranged above display screen 4, display screen display pupillometry software input picture, measurement result and measurement result change curve;This display screen is towards personnel such as doctors, it is simple to observe.
The handle position of equipment is internally installed single-chip microcomputer 10 and power supply 11, single-chip microcomputer provides the running environment of pupil tracing Survey Software, it is responsible for the input and output of camera control and collection, it is responsible for the signal input of various light sources, is responsible for the display driving etc. of display screen, be connected with infrared camera, light source, display screen by control line and data wire.Power supply 11 provides power supply to camera and single-chip microcomputer, it is possible to providing power supply for other light sources, power supply supports alternating current charging, conveniently uses.
On the left of display screen and right side has button 1,2,3,1 to be facility switching button, and 2 is stimulating light source knob, and 3 is pupil tracing button, and wherein stimulating light source knob and pupil tracing button are each about display screen installs one group, facilitates right-hand man all operable.
The system structure of the present invention is light, small and exquisite, and user only need to open facility switching, holds equipment handle, equipment is placed on person under inspection at the moment, and pupil image occurs in screen to be shown, presses trace button and can start to measure, and measurement result is shown on screen.Then user can also be tracked measuring for the illumination of time and lighting source that different patients regulate stimulating light source.After having checked, result can be sent to other terminal, such as printer, printing audit report.
Embodiment 3:
The present embodiment carries out on the basis of aforesaid embodiment 1 or 2, with previous embodiment the difference is that, grasping type equipment has been carried out further perfect by the present embodiment.
Binocular pupillary light reflex is followed the tracks of system and is included grasping type equipment, described grasping type equipment top is measurement portion, bottom is handle, and measurement portion, handle are all with built-in space, for installation infrared camera, infrared illumination source, single-chip microcomputer, stimulating light source, power supply;The handle position of grasping type equipment is internally installed single-chip microcomputer and power supply;The measurement portion front side surface of grasping type equipment is embedded with display screen, and display screen is connected with single-chip microcomputer;Display screen bottom right side has shift knob, and on the left of display screen and right side has stimulating light source knob, pupil tracing button respectively, and wherein stimulating light source knob and pupil tracing button are each about display screen installs one group;On rear side of the measurement portion of grasping type equipment, embedded two are subject to inspection position, are soft bumper ring by examining around position;Be subject to examine above position at each, the measurement portion of grasping type equipment is provided with infrared camera, infrared illumination source, stimulating light source near the position of end face;Two camera each separate connection single-chip microcomputers;Two infrared illumination source are connected to single-chip microcomputer;Power supply is connected to infrared camera, single-chip microcomputer, infrared illumination source, infrared camera, stimulating light source.
In described system, device is connected by data wire.
Further, described system is also circumscribed with computer, printer.
Further, described system also includes wireless signal transmission end.
Further, described grasping type equipment is furnished with packing crates, arranges the foam pad of hollow in packing crates, and the formed space of hollow space is slightly larger than grasping type equipment.
Further, a supporting frame used with described grasping type coordinative composition of equipments is also included.
Further, it is furnished with the roller of 3 and more than 3 bottom described supporting frame.
Embodiment 4:
The present embodiment carries out on the basis of aforesaid embodiment 1 or 2 or 3, with previous embodiment the difference is that, the suitability of grasping type equipment has been done higher design by the present embodiment.
In order to the suitability making grasping type equipment is higher, make following design.
Described handle arranges charging inlet and data derive port;Described handle is rectangular or square when stiff shell, in each side of handle, has the salient line (sword) of vertical up/down perforation.
Described handle has supporting Mobile base, and Mobile base is configured to: including base, base is rectangular, and base corner is respectively arranged with 1 spiral regulating device, and spiral regulating device realizes the lifting at each angle, and heave amplitude is ± 20mm.Each spiral regulating device bottom is soft rubber pad, for anti-skidding and buffering.
Being la m at submounts, base is connected by slide rail, slide block with la m, coordinates the first handwheel, the first leading screw to realize la m horizontal cross back and forth movement on base;
It is arranged above top plate, la m and top plate at la m to be connected by slide rail, slide block, by the second handwheel, the second leading screw, it is achieved top plate is level longitudinal direction back and forth movement on la m;
End face at top plate, it is welded with mounting post, mounting post bottom welding is on top plate, mounting post top hollow, it is formed with rectangular or square when plug space, plug each side, space, with the groove of vertical up/down perforation, is with reeded plug space and handle suitable, it is achieved handle slides in plug space and is tightly combined.
Further, a rectangle steel disc is stretched out at mounting post upper position, rectangle steel disc horizontal positioned, it is fixed in mounting post by welding manner, rectangle steel disc width 1-2cm, long 3-8cm, it screw of spinning in and out can support the first levelling tube that horizontal cross is placed by two, be used for indicating level.By described screw, it is achieved the calibration to levelling tube.Similar, on top plate, level is longitudinally provided with the second level pipe.
Further, salient line, groove are suitable, it is possible to be 5-55cm for semicircle, circular arc or triangle, length or the degree of depth.
Further, described handle casing and mounting post are that hard material is made, it is possible to be 304 steel, it is also possible to be aluminium alloy.
Further, salient line, groove surfaces are coated with a small amount of lubricating oil.
Further, before measuring, handle is inserted plug space, by the spiral regulating device on adjusting base, make the first levelling tube and the second level pipe bubble placed in the middle, then regulate the first handwheel, the second handwheel, make grasping type equipment be in person under inspection's dead ahead, and then the spiral regulating device on adjusting base, make the first levelling tube and the second level pipe bubble placed in the middle.Person under inspection detects near grasping type equipment.
Further, regulate for realizing vertical height, make following design: mounting post is hollow structure generally, it is formed with rectangular or square when plug space, plug side, three, space is with the groove of vertical up/down perforation, at opposite side, vertically through fluting is set, slotting position is horizontally inserted a screw, it is semicircle spheroid that this screw stretches into one end of mounting post, this screw stretches out one end of mounting post and includes screw adjusting nut, screw screens in mounting post can be realized by screwing adjusting nut, thus stoping handle downslide in hollow structure, by this screw, realize handle is inserted the adjustment of height and position.
Need to illustrate time, when to handle height and position seated regulate after, it is still desirable to make the first levelling tube and the second level pipe bubble placed in the middle.
Further, there is annular knurl on described screw adjusting nut surface, and knurl depth is 1mm.
Embodiment 5:
The present embodiment carries out on the basis of aforesaid embodiment 1 or 2 or 3 or 4, with previous embodiment the difference is that, pupil tracing measurement module has been designed by the present embodiment.
nullIn conjunction with accompanying drawing 3,It is the pupil tracing measurement module schematic diagram of the present invention,After system module input pupil image,Pupil threshold value is calculated by the threshold calculation module 01 based on pupil gray feature,Based on pupil threshold value,Carried out obscuring location Calculation to pupil barycenter by the fuzzy locating module 02 of pupil barycenter,Draw the rough barycenter of pupil,The effectiveness of pupil barycenter is verified by pupil barycenter authentication module 03,If it is invalid,Then follow the trail of failure,Otherwise predicted that pupil tracking module 04 predicts pupil region by pupil region,Pupil it is accurately positioned in estimation range,Namely pupil barycenter pinpoint module 05 obtains accurate pupil center-of-mass coordinate,Pupil barycenter is verified by pupil barycenter authentication module 06,If invalid, failure,Otherwise enter pupil diameter computing module 07 and draw pupil diameter,Namely a two field picture has been followed the trail of.All picture charge patterns in time to be detected complete, pupil data analyzing and processing will be drawn measurement result by the analysis module of pupil tracing measurement module, the parameters such as such as reaction of pupil to light incubation period, pupil contraction speed, pupil contraction ratio, then can for the state of an illness measuring parameter and analyzing further testee.
It should be noted that if it is desired to draw pupil diameter change curve, it is necessary at least one pupil of continuous detecting concussion cycle, so that data precision is reliable.
Prior art has been improved by the present invention, therefore has used for reference prior art in implementation process, as space is limited, prior art part is not described in detail;The NM technology segment of every present invention, all can adopt existing techniques in realizing.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.All within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention.