CN105520713A - Binocular pupil light reflex measuring equipment - Google Patents
Binocular pupil light reflex measuring equipment Download PDFInfo
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- CN105520713A CN105520713A CN201510861574.2A CN201510861574A CN105520713A CN 105520713 A CN105520713 A CN 105520713A CN 201510861574 A CN201510861574 A CN 201510861574A CN 105520713 A CN105520713 A CN 105520713A
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Abstract
The invention discloses binocular pupil light reflex measuring equipment, which comprises a binocular pupil imaging system and a pupil tracing measuring system, wherein the binocular pupil imaging system comprises a first infrared illumination light source, a second infrared illumination light source, a first stimulation light source, a second stimulation light source, a sighting mark device, a resolution device, an infrared optical filter, a telecentric lens and an infrared detector. The equipment has the advantages that the stimulation light source time is adjustable; the pupil measurement with the binocular interpupillary distance being 50 to 80mm can be supported; the equipment precision is high; the two pupils realize the completely synchronous imaging; the precision of a pupil tracing measuring algorithm is high; the fast measurement can be realized; and the use is convenient.
Description
Technical field
The present invention relates to pupillometry technical field, be specifically related to a kind of binocular pupillary light reflex measurement device.
Background technology
The acquisition of information organ that eyes are wanted as body weight for humans, while acquisition ambient light radiation information, also reflects the pathological changes situation of the multiple tissue of human body and organ.By to the observation of eyes with measure and not only ophthalmic diseases can be found, even early diagnosis can be carried out to some systemic diseases.Wherein, be the indispensable link of most indagation and operation to the accurate measurement of pupil diameter and size variation thereof.
Pupil refers to the perforate in the middle of iris, and the pupil diameter of adult is generally 2.5-4mm, lateral symmetry.Extraneous light enters eye imaging on the retina by pupil.Pupil can reduce at bright place, in the dark can increase, and which control the luminous flux entering eyes, makes object on the retina while blur-free imaging, avoids again excessive light to burn retina.Outside the Pass having with ambient light intensity, the size of pupil is relevant with factors such as age, dioptric, physiological status, environmental stimuli and emotions.Generally, old people's pupil is less, and child is larger to the pupil in adult's stage; The male of same age is less than the pupil of women; Time nervous, exciting, pupil can magnify, and keeps quite, pupil just reduces when sleeping.
In medical science, for normal human eye, when illumination is penetrated at a glance, illuminated eye and another eye pupil hole can reduce simultaneously.Afferent pupillary disturbance refers to the pathological changes etc. being positioned at retina, optic nerve, be spiritually attracted fork, tractus opticus or tectum of midbrain, optical stimulus signal is imported into and is obstructed, and can not normally reach pupil movement maincenter, causes reaction of pupil to light ability to decline.If only there is afferent pupillary disturbance and another emmetropia, or two afferent pupillary disturbance degree are asymmetric, are called neuroretinal rim area (relativeafferentpupillarydefect, RAPD) at a glance.The inspection method of current neuroretinal rim area has alternately luminescence method, neutral-density filter method, three seconds batch technique inclining test methods, Pupillometer inspection techniques etc.
Alternately illumination inspection technique is carried out in darkroom, and examinee first sits quietly adaptation 5 minutes, and watches sighting target at a distance attentively.Before inspection, first record pupil of both eyes size, avoid bilateral anisocoria on the impact of check result.During inspection, irradiate tested eye in about 3 ~ 5mm place with 3V concentration torch downwards at tested eye dead ahead, light source be avoided to irradiate from the side.Irradiate about 1s, then promptly pocket lamp is moved to another eye, alternately irradiate, the dynamic change of observation and comparison pupil diameter with stable frequency between two, if the eye that during illumination, pupil reduces rapidly is normal eyes, the comparatively loose large eye of pupil is for suffering from eye.
Neutral-density filter method is on the basis of alternately illumination inspection technique, is placed at the moment by the neutral colour filter of certain density, changes optical filter and reaction of pupil to light is balanced, and now optical filter density just characterizes the order of severity of RAPD symptom.The optical filter density of general employing is 0.3,0.6,0.9,1.2log unit, and range is limited, cannot quantificational expression for the RAPD being less than 0.3log.
Within three seconds, batch technique inclining test method still adopts the method for eyes alternate illumination, just by the time lengthening to 3 of light-illuminating second.According to the pupillary reaction situation of the more weak eye of reaction, to RAPD classification.
Instrument for examining pupil can provide alternately illumination automatically, and can accurate controlled light time and intensity, adopt infrared lens Measurement accuracy, record pupil to the whole dynamic changing process of illumination, and by software, measurement result is analyzed, accurate judgement is made to the rank of RAPD.Compared with traditional observation measurements, instrument for examining pupil has high accuracy, measures the advantages such as convenient, intelligent.The shortcoming of existing instrument for examining pupil is:
1, adopt two camera lenses and CCD (charge coupled cell), system cost is high, is difficult to popularize;
2, adopt common lens, optical system amplification can change to the change of distance of camera lens with human eye, there is perspective effect, for different people, cannot draw the precise radius of pupil;
3, the use of two CCD, makes pupil image poor synchronization, can not the dynamic change of actual response two pupils;
4, need to regulate distance between two lens barrels according to different interpupillary distances, it is convenient not to measure.
Summary of the invention
The object of the invention is to, a kind of binocular pupillary light reflex measurement device is provided, the poor synchronization of the pupil image imaging of low, two eyes of accuracy that pupil radium that prior art exists is measured, measurement is convenient not, cost is high problem can be solved.
For this purpose, the present invention proposes a kind of binocular pupillary light reflex measurement device, comprising:
Binocular pupil image system and pupil tracing measuring system; Wherein,
Described binocular pupil image system comprises the first infrared illumination source, second infrared illumination source, first stimulating light source, second stimulating light source, visual testing sign device, folding is as device, infrared fileter, telecentric lens and Infrared Detectors, described first infrared illumination source is connected with described pupil tracing measuring system with the second infrared illumination source, light illumination is controlled by described pupil tracing measuring system, described first stimulating light source is connected with described pupil tracing measuring system with the second stimulating light source, light illumination and stimulation time is controlled by described pupil tracing measuring system, described Infrared Detectors is connected with described pupil tracing measuring system, the collection carrying out pupil image is controlled by described pupil tracing measuring system,
Described visual testing sign device is away from person's eyes to be measured, and be positioned at described person to be measured two mid-eye dead ahead predeterminable range places, described folding is positioned at the dead ahead of described person's eyes to be measured as device near described two eyes, described first infrared illumination source, second infrared illumination source, first stimulating light source and the second stimulating light source are integrated in described folding as device inside, described infrared fileter is positioned at the exit of described folding as device, and after connect described telecentric lens, described Infrared Detectors is connect after described telecentric lens, described Infrared Detectors is between described telecentric lens and visual testing sign device, and be positioned in the image planes of described telecentric lens,
Described folding comprises baffle plate as device, first time reflecting mirror, second time reflecting mirror, first upper reflector, second upper reflector and reflecting prism, described baffle plate is between described two eyes, its position can make described first infrared illumination source and the second infrared illumination source stimulate described two eyes simultaneously respectively and not interfere with each other, described first time reflecting mirror and second time reflecting mirror lay respectively at left eye and the right eye dead ahead of described person to be measured, and from the horizontal by 45° angle, described first time reflecting mirror and second time reflecting mirror use near-infrared reflection, the material of visible transmission is made, described first upper reflector and the second upper reflector lay respectively at directly over described first time reflecting mirror and second time reflecting mirror, and from the horizontal by 45° angle, described reflecting prism is positioned in the middle of described first upper reflector and the second upper reflector, described first infrared illumination source and the second infrared illumination source lay respectively at the lower limb of described first time reflecting mirror and second time reflecting mirror, the bright spot that described first infrared illumination source and the second infrared illumination source are formed at described person's inside ofeye to be measured drops on pupil inside, described first stimulating light source and the second stimulating light source lay respectively at the back side of described first time reflecting mirror and second time reflecting mirror, and just to described person's eyes to be measured,
Described pupil tracing measuring system, for obtaining described first infrared illumination source, the second infrared illumination source is luminous, and described first stimulating light source, the pupil image of described two eyes that described Infrared Detectors gathers under a stimulating light source luminance in the second stimulating light source, described pupil image is processed, obtains the radius of pupil and the position of barycenter in described pupil image.
The beneficial effect of method equipment of the present invention is:
1, employ telecentric lens, the change of camera lens amplification can not be caused because of the distance of eye distance camera lens, avoid perspective effect, improve measurement accuracy;
2, adopt folding, as light path, binocular pupil is incorporated in imaging on a camera, and turned back by light path whole imaging target surface is fully utilized, while guarantee pupil radium certainty of measurement, reduce cost, effectively improve synchronicity;
3, for different interpupillary distances, do not need to make any manual adjustments, directly just can measure, simple and quick;
4, be configured with visual testing sign device, in measuring process, human eye can annotate sighting target, avoids Rotation of eyeball to cause measurement result inaccurate.
Accompanying drawing explanation
The schematic flow sheet of Fig. 1 involved by a kind of binocular pupillary light reflex of the present invention measurement device;
Fig. 2 is the axonometric drawing of folding as device of binocular pupillary light reflex measurement device of the present invention;
Fig. 3 is the top view of the folding in Fig. 2 as device;
Fig. 4 is the side view of the folding in Fig. 2 as device;
Fig. 5 is the front view of the folding in Fig. 2 as device;
The schematic flow sheet of Fig. 6 involved by the pupil tracing measuring system of a kind of binocular pupillary light reflex of the present invention measurement device.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Referring to Fig. 1, the present embodiment discloses a kind of binocular pupillary light reflex measurement device, comprising:
Binocular pupil image system 1 and pupil tracing measuring system 2; Wherein,
Described binocular pupil image system 1 comprises the first infrared illumination source, second infrared illumination source, first stimulating light source, second stimulating light source, visual testing sign device, folding is as device, infrared fileter, telecentric lens and Infrared Detectors, described first infrared illumination source is connected with described pupil tracing measuring system 2 with the second infrared illumination source, light illumination is controlled by described pupil tracing measuring system 2, described first stimulating light source is connected with described pupil tracing measuring system 2 with the second stimulating light source, light illumination and stimulation time is controlled by described pupil tracing measuring system 2, described Infrared Detectors is connected with described pupil tracing measuring system 2, the collection carrying out pupil image is controlled by described pupil tracing measuring system 2,
Described visual testing sign device is away from person's eyes to be measured, and be positioned at described person to be measured two mid-eye dead ahead predeterminable range places, described folding is positioned at the dead ahead of described person's eyes to be measured as device near described two eyes, described first infrared illumination source, second infrared illumination source, first stimulating light source and the second stimulating light source are integrated in described folding as device inside, described infrared fileter is positioned at the exit of described folding as device, and after connect described telecentric lens, described Infrared Detectors is connect after described telecentric lens, described Infrared Detectors is between described telecentric lens and visual testing sign device, and be positioned in the image planes of described telecentric lens,
Described folding comprises baffle plate as device, first time reflecting mirror, second time reflecting mirror, first upper reflector, second upper reflector and reflecting prism, described baffle plate is between described two eyes, its position can make described first infrared illumination source and the second infrared illumination source stimulate described two eyes simultaneously respectively and not interfere with each other, described first time reflecting mirror and second time reflecting mirror lay respectively at left eye and the right eye dead ahead of described person to be measured, and from the horizontal by 45° angle, described first time reflecting mirror and second time reflecting mirror use near-infrared reflection, the material of visible transmission is made, described first upper reflector and the second upper reflector lay respectively at directly over described first time reflecting mirror and second time reflecting mirror, and from the horizontal by 45° angle, described reflecting prism is positioned in the middle of described first upper reflector and the second upper reflector, described first infrared illumination source and the second infrared illumination source lay respectively at the lower limb of described first time reflecting mirror and second time reflecting mirror, the bright spot that described first infrared illumination source and the second infrared illumination source are formed at described person's inside ofeye to be measured drops on pupil inside, described first stimulating light source and the second stimulating light source lay respectively at the back side of described first time reflecting mirror and second time reflecting mirror, and just to described person's eyes to be measured,
Described pupil tracing measuring system 2, for obtaining described first infrared illumination source, the second infrared illumination source is luminous, and described first stimulating light source, the pupil image of described two eyes that described Infrared Detectors gathers under a stimulating light source luminance in the second stimulating light source, described pupil image is processed, obtains the radius of pupil and the position of barycenter in described pupil image.
This equipment stimulating light source time is adjustable, and support the pupillometry of binocular interpupillary distance between 50 ~ 80mm, equipment degree of accuracy is high, the imaging of two pupil Complete Synchronizations, and pupil tracing Measurement Algorithm precision is high, can Quick Measurement, easy to use.
Binocular pupillary light reflex measurement device described in the embodiment of the present invention, employs telecentric lens, can not cause the change of camera lens amplification, can avoid perspective effect because of the distance of eye distance camera lens, improves measurement accuracy; Adopt folding, as light path, binocular pupil is incorporated in imaging on a camera, and turned back by light path whole imaging target surface is fully utilized, while guarantee pupil radium certainty of measurement, reduce cost, effectively improve synchronicity; For different interpupillary distances, do not need to make any manual adjustments, directly just can measure, simple and quick; Be configured with visual testing sign device, in measuring process, human eye can annotate sighting target, avoids Rotation of eyeball to cause measurement result inaccurate.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, described predeterminable range is 25m.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, the stimulation time of described first stimulating light source and the second stimulating light source is 200ms, 400ms or 1000ms.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, described pupil tracing measuring system, for intercepting pupil region image from described pupil image, from described pupil region image, extract pupil edge image, calculate the radius of pupil and the position of barycenter in described pupil image according to described pupil edge image.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, described pupil tracing measuring system, for estimating the center of pupil in described pupil image, carry out the intercepting of pupil region image according to the center of described pupil, obtain pupil region image.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, described pupil tracing measuring system, for the center according to described pupil, the pupil region in described pupil image is positioned, carry out the intercepting of pupil region image according to positioning result, obtain pupil region image.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, described pupil tracing measuring system, for the center according to pupil in the first frame pupil image, the pupil region in described first frame pupil image is positioned, the intercepting of pupil region image is carried out according to the positioning result of the pupil region in described first frame pupil image, obtain the pupil region image in described first frame pupil image
For positioning the pupil region in the second frame pupil image according to the positioning result of the pupil region in described first frame pupil image, carry out the intercepting of pupil region image according to the positioning result of the pupil region in described second frame pupil image, obtain the pupil region image in described second frame pupil image.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, described pupil tracing measuring system, also for before extract pupil edge image from described pupil region image, carries out noise reduction process to described pupil region image.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, described pupil tracing measuring system, for by carrying out carrying out image threshold segmentation to described pupil region image, extracts pupil edge image from described pupil region image.
Alternatively, in another embodiment of binocular pupillary light reflex measurement device of the present invention, described pupil tracing measuring system, also for the radial difference of pupil and the position deviation of barycenter of two eyes according to the radius of the pupil in described pupil image and the position calculation of barycenter, according to the radial difference of pupil and the position deviation of barycenter of described two eyes, and the disease mapping table preset obtains the state of an illness result of the neuroretinal rim area of described person to be measured, wherein, described disease mapping table comprises a left side, the radial difference field of the pupil of right eye eyeball, left, the position deviation field of the barycenter of the pupil of right eye eyeball and the state of an illness result of neuroretinal rim area.
Below in conjunction with accompanying drawing, the present invention is described in further detail:
Accompanying drawing 1 is structural representation of the present invention, comprises binocular pupil image system and pupil tracing measuring system.Wherein, imaging system comprises two infrared illumination source, two stimulating light sources, visual testing sign device, folding as device, infrared fileter, telecentric lens and Infrared Detectors, and pupil tracing measuring system is integrated in computer.Light source is connected with computer with infrared CCD, by the collection of computer software control light illumination and Infrared Detectors image.Pupil tracing measuring system is carried out tracking to the image of Infrared Detectors collection and is measured, and carries out analyzing and processing to measurement result.Infrared illumination source and the stimulating light source illumination of binocular pupil image internal system regulate by computer software, different light illuminations and stimulating light source time is selected according to user's request, as: stimulating light source stimulation time can select 200ms, 400ms, 1000ms.
Measurement result is shown on computer display, supports the display of pupil image and measurement result.
The output of pupil tracing measuring system supported data and the output of measurement report, so that further inventory analysis.
Accompanying drawing 2 to 5 is a kind of light channel structure schematic diagram of the present invention, be respectively axonometric drawing, top view, side view and front view, comprise two infrared illumination source 6A, 6B (i.e. structure shown in 6 in Fig. 4), two stimulating light source 7A, 7B (i.e. structure shown in 7 in Fig. 4), roll over as device 12, infrared fileter 8, telecentric lens 9, Infrared Detectors 10, sighting target 11.Sighting target 11 is positioned at two mid-eye dead ahead 25cm places, folding is positioned at the dead ahead of eyes as device 12, two infrared illumination source 6A, 6B and two stimulating light sources 7A, 7B are integrated in folding as device inside, infrared fileter 8 is positioned at the exit of folding as device, after connect telecentric lens 9, Infrared Detectors 10 is positioned in the image planes of two eyes 1A, 1B, and is connected with computer by data line.
Folding also comprises baffle plate 2 as device 12, two lower reflecting mirror 3A, 3B (i.e. structure shown in 3 in Fig. 4), two upper reflector 4A, 4B (i.e. structure shown in 4 in Fig. 4) and reflecting prism 5.Wherein, baffle plate 2 is between two eyes, and its position will guarantee that infrared illumination source 6A, 6B stimulate two eyes 1A, 1B respectively and do not interfere with each other.Lower reflecting mirror 3A, 3B are positioned at eyes dead ahead, and from the horizontal by 45° angle, upper reflector 4A, 4B are positioned at directly over lower reflecting mirror 3A, 3B, and from the horizontal by 45° angle, reflecting prism 5 is positioned in the middle of upper reflector 4A, 4B.Two infrared illumination source 6A, 6B are positioned at the lower limb of lower reflecting mirror 3A, 3B, controlled to open, guarantee that infrared illumination source drops on pupil inside in the bright spot that inside ofeye is formed, in order to avoid affect pupillometry precision by computer.Stimulating light source 7A, 7B are positioned at the back side of lower reflecting mirror 3A, 3B, just to eyes, are controlled the stimulation time of opening and closing and stimulating light source by pupil tracing measuring system.
During measurement, measured is near rolling over as device 12, the visual sighting target 11 of human eye 1A, 1B, control infrared illumination source 6A, 6B on computers luminous, after the light sent is reflected by eyes 1A, 1B, through lower reflecting mirror 3A, 3B, the reflection of upper reflector 4A, 4B and reflecting prism 5, enter telecentric lens 9, be imaged on Infrared Detectors 10, pupil image is presented on computer display the most at last.There is pupil image in machine display screen to be calculated, click a trace button, one of them stimulating light source flashes, and person under inspection keeps eyes to open, and Infrared Detectors gathers two pupil image, is finally presented on screen by measurement result; Click another trace button, another one stimulating light source flashes, and person under inspection keeps eyes to open, and Infrared Detectors gathers two pupil image, finally measurement result is presented on screen.User also can regulate the time of stimulating light source then to carry out tracking for different patient and measure.After having checked, result can be preserved, and print audit report.
Accompanying drawing 6 is the handling process schematic diagram of pupil tracing measuring system of the present invention, after system input pupil image, gray feature first based on pupil image estimates pupil of both eyes center, carry out the oculopupillary just location of people, carry out the intercepting of pupil image, remove the remainder especially interference of bridge of the nose part inactive area between eyes, improve measuring speed.Again the pretreatment such as the elimination of the noise such as bright spot, eyelashes are carried out to the pupil image region after intercepting.Threshold segmentation is carried out to pretreated image, extracts pupil edge, calculate barycenter and radius, compare the data difference of pupil of both eyes.Limit next frame pupil position fast by tracing algorithm and accelerate detection speed, the real-time positioning realizing pupil is followed the trail of.To be detectedly to complete, will the data difference of pupil of both eyes under simple eye stimulation be drawn, according to the relation quantitative analysis state of an illness of itself and RAPD.
Although describe embodiments of the present invention by reference to the accompanying drawings, but those skilled in the art can make various modifications and variations without departing from the spirit and scope of the present invention, such amendment and modification all fall into by within claims limited range.
Claims (10)
1. a binocular pupillary light reflex measurement device, is characterized in that, comprising:
Binocular pupil image system and pupil tracing measuring system; Wherein,
Described binocular pupil image system comprises the first infrared illumination source, second infrared illumination source, first stimulating light source, second stimulating light source, visual testing sign device, folding is as device, infrared fileter, telecentric lens and Infrared Detectors, described first infrared illumination source is connected with described pupil tracing measuring system with the second infrared illumination source, light illumination is controlled by described pupil tracing measuring system, described first stimulating light source is connected with described pupil tracing measuring system with the second stimulating light source, light illumination and stimulation time is controlled by described pupil tracing measuring system, described Infrared Detectors is connected with described pupil tracing measuring system, the collection carrying out pupil image is controlled by described pupil tracing measuring system,
Described visual testing sign device is away from person's eyes to be measured, and be positioned at described person to be measured two mid-eye dead ahead predeterminable range places, described folding is positioned at the dead ahead of described person's eyes to be measured as device near described two eyes, described first infrared illumination source, second infrared illumination source, first stimulating light source and the second stimulating light source are integrated in described folding as device inside, described infrared fileter is positioned at the exit of described folding as device, and after connect described telecentric lens, described Infrared Detectors is connect after described telecentric lens, described Infrared Detectors is between described telecentric lens and visual testing sign device, and be positioned in the image planes of described telecentric lens,
Described folding comprises baffle plate as device, first time reflecting mirror, second time reflecting mirror, first upper reflector, second upper reflector and reflecting prism, described baffle plate is between described two eyes, its position can make described first infrared illumination source and the second infrared illumination source stimulate described two eyes simultaneously respectively and not interfere with each other, described first time reflecting mirror and second time reflecting mirror lay respectively at left eye and the right eye dead ahead of described person to be measured, and from the horizontal by 45° angle, described first time reflecting mirror and second time reflecting mirror use near-infrared reflection, the material of visible transmission is made, described first upper reflector and the second upper reflector lay respectively at directly over described first time reflecting mirror and second time reflecting mirror, and from the horizontal by 45° angle, described reflecting prism is positioned in the middle of described first upper reflector and the second upper reflector, described first infrared illumination source and the second infrared illumination source lay respectively at the lower limb of described first time reflecting mirror and second time reflecting mirror, the bright spot that described first infrared illumination source and the second infrared illumination source are formed at described person's inside ofeye to be measured drops on pupil inside, described first stimulating light source and the second stimulating light source lay respectively at the back side of described first time reflecting mirror and second time reflecting mirror, and just to described person's eyes to be measured,
Described pupil tracing measuring system, for obtaining described first infrared illumination source, the second infrared illumination source is luminous, and described first stimulating light source, the pupil image of described two eyes that described Infrared Detectors gathers under a stimulating light source luminance in the second stimulating light source, described pupil image is processed, obtains the radius of pupil and the position of barycenter in described pupil image.
2. binocular pupillary light reflex measurement device according to claim 1, is characterized in that, described predeterminable range is 25m.
3. binocular pupillary light reflex measurement device according to claim 1, is characterized in that, the stimulation time of described first stimulating light source and the second stimulating light source is 200ms, 400ms or 1000ms.
4. binocular pupillary light reflex measurement device according to claim 1, it is characterized in that, described pupil tracing measuring system, for intercepting pupil region image from described pupil image, from described pupil region image, extract pupil edge image, calculate the radius of pupil and the position of barycenter in described pupil image according to described pupil edge image.
5. binocular pupillary light reflex measurement device according to claim 4, it is characterized in that, described pupil tracing measuring system, for estimating the center of pupil in described pupil image, carry out the intercepting of pupil region image according to the center of described pupil, obtain pupil region image.
6. binocular pupillary light reflex measurement device according to claim 5, it is characterized in that, described pupil tracing measuring system, for the center according to described pupil, the pupil region in described pupil image is positioned, carry out the intercepting of pupil region image according to positioning result, obtain pupil region image.
7. binocular pupillary light reflex measurement device according to claim 5, it is characterized in that, described pupil tracing measuring system, for the center according to pupil in the first frame pupil image, the pupil region in described first frame pupil image is positioned, the intercepting of pupil region image is carried out according to the positioning result of the pupil region in described first frame pupil image, obtain the pupil region image in described first frame pupil image
For positioning the pupil region in the second frame pupil image according to the positioning result of the pupil region in described first frame pupil image, carry out the intercepting of pupil region image according to the positioning result of the pupil region in described second frame pupil image, obtain the pupil region image in described second frame pupil image.
8. binocular pupillary light reflex measurement device according to claim 4, is characterized in that, described pupil tracing measuring system, also for before extract pupil edge image from described pupil region image, carries out noise reduction process to described pupil region image.
9. binocular pupillary light reflex measurement device according to claim 4, is characterized in that, described pupil tracing measuring system, for by carrying out carrying out image threshold segmentation to described pupil region image, from described pupil region image, extracts pupil edge image.
10. binocular pupillary light reflex measurement device according to claim 1, it is characterized in that, described pupil tracing measuring system, also for the radial difference of pupil and the position deviation of barycenter of two eyes according to the radius of the pupil in described pupil image and the position calculation of barycenter, according to the radial difference of pupil and the position deviation of barycenter of described two eyes, and the disease mapping table preset obtains the state of an illness result of the neuroretinal rim area of described person to be measured, wherein, described disease mapping table comprises a left side, the radial difference field of the pupil of right eye eyeball, left, the position deviation field of the barycenter of the pupil of right eye eyeball and the state of an illness result of neuroretinal rim area.
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| CN109259723A (en) * | 2018-09-21 | 2019-01-25 | 中国科学院苏州生物医学工程技术研究所 | Novel RAPD detector |
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