CN104688948A - Traditional Chinese medicine composition for treating piglet diarrhea and chicken colibacillosis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating piglet diarrhea and chicken colibacillosis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating piglet diarrhea and chicken colibacillosis. The traditional Chinese medicine composition is a medicament composed of the following crude traditional Chinese medicine of, by weight, 23 to 27 parts of dandelions, 23 to 27 Chinese violet, 23 to 27 parts of flos chrysanthemi indici and 23 to 27 parts of oldenlandia diffusa. Water is added to a mixture of the mentioned traditional Chinese medicine, the mixture is boiled, filtered, concentrated and spray-dried, and therefore medicine powder is acquired. The traditional Chinese medicine composition has the obvious restraining effect on pathogenic bacterium escherichia coli commonly seen from pigs and chickens, can completely replace antibiotics to prevent and treat piglet diarrhea and chicken colibacillosis and is new environment-friendly and safe veterinary medicine which is safe and free of side effect and residues.
Description
Technical field
The present invention relates to technical field of Chinese medicines, especially relate to the Chinese medicine composition and preparation method thereof of a kind of substitute antibiotics for piglet diarrhea and chicken colibacillosis
Background technology
In aquaculture, diarrhea of weaned piglets is pig farm common frdquently encountered disease, and chicken colibacillosis is also a kind of regular incidence that in poultry, morbidity is maximum, treatment cost is maximum.The Main Pathogenic Bacteria of diarrhea of weaned piglets and chicken colibacillosis is all gram negative bacteria---escherichia coli.Main prevention and controls in feedstuff, adds the antibiosis such as a large amount of colistin sulfates, florfenicol with cultivation site usually prevent and treat at present.But along with antibiotic long-term a large amount of use, antibacterial is to drug resistant on the one hand, brings huge hidden danger on the other hand in order to the overdose that is effective uses to livestock product safety.In order to ensure livestock product safety, the current Ministry of Agriculture strictly forbids the detection of overdose abuse of antibiotics and increasing livestock products drug residue in feedstuff, cause plant to be fallen ill after feed factory restriction antibiotic usage to increase, have a strong impact on feed quality and culture benefit, particularly export broiler to control due to drug residue, the cultivation later stage can not use antibiotic to cause a large amount of chicken morbidities dead, causes huge loss.Therefore feed factory and plant are to antibiotic sub demand very greatly, but also do not have the antibiotic of very effectively against gram-negative bacteria to replace product at present.
The Chinese prescription for the treatment of piglet diarrhea traditional is at present the Chinese medicines such as Radix Scutellariae, Rhizoma Coptidis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Folium Perillae, Herba Pogostemonis mostly, the prescription that the compound recipes such as current Herba Taraxaci, Herba Violae extract also is not seen in word, belong to more new-type prescription, particularly replace antibiotic prescription and technology to belong to pioneering at livestock by prescription compatibility screening and optimizing antibacterial action.
Summary of the invention
For the problems referred to above that prior art exists, the invention provides and a kind ofly treat Chinese medicine composition of piglet diarrhea and chicken colibacillosis and preparation method thereof.In Chinese medicine composition of the present invention, each component cooperatively interacts, and complements each other, and synergism makes it have obvious therapeutical effect to piglet diarrhea and chicken colibacillosis.
Technical scheme of the present invention is as follows:
Treat a Chinese medicine composition for piglet diarrhea and chicken colibacillosis, described Chinese medicine composition is the medicament that the raw material of Chinese medicine of following weight proportioning is made:
Herba Taraxaci 23 ~ 27 parts, Herba Violae 23 ~ 27 parts, Flos Chrysanthemi Indici 23 ~ 27 parts, Herba Hedyotidis Diffusae 23 ~ 27 parts.Described medicament is powder.
A preparation method for described Chinese medicine composition, comprises the steps:
(1) Herba Taraxaci 23 ~ 27 parts, Herba Violae 23 ~ 27 parts, Flos Chrysanthemi Indici 23 ~ 27 parts, Herba Hedyotidis Diffusae 23 ~ 27 parts is taken respectively;
(2), after being mixed by the raw material taken, add the hot water of raw material gross weight 10 ~ 12 times, heated and boiled 3 hours, filters to get filtrate and filtering residue;
(3) add the hot water of gross weight 8 ~ 10 times in the filtering residue obtained to step (2), heated and boiled 2.5 hours, filter and obtain filtrate and filtering residue;
(4) filtrate of combining step (2) and step (3) gained, natural cooling, and concentrated to reach density be 1.1 ~ 1.2;
(5) concentrated solution is evacuated in spray dryer carry out spray do, obtain Powdered finished product.
The temperature of described step (2) and the middle hot water of step (3) is 70 ~ 90 DEG C.
In described step (4), concentration process adopts dual-effect concentrator, and wherein, an effect vacuum and evaporating temperature are :-0.04 ~-0.07MPa, 85 DEG C; Two effect vacuums and evaporating temperature are :-0.06 ~-0.10MPa, 75 DEG C.
Parameters in described step (5) during spray dryer work is: inlet temperature is 140 ~ 160 DEG C, and leaving air temp is 70 ~ 90 DEG C.
The technique effect that the present invention is useful is:
1, the present invention is mainly used in preventing and treating piglet diarrhea, has specially good effect to the diarrhoea that the multiple pathogen infections such as virus, antibacterial cause, and has safety and has no side effect, and soon effective, transference cure is fast, the features such as effect is rapid.
2, the present invention has the very strong Herba Taraxaci of antibacterial activity by screening from Chinese medicine, Herba Violae, Flos Chrysanthemi Indici, Herba Hedyotidis Diffusae a few herbs carry out reasonable combination compatibility, significantly improve its antibacterial effect, Antibiotics kill escherichia coli can be replaced completely, these Chinese medicines have the effect of heat-clearing and toxic substances removing, anti-inflammation simultaneously, compare with antibiotic and not only there is antibiotic antibacterial action, but also have antibiotic do not have in and bacterial endotoxin and antiinflammatory action, therefore clinical treatment piglet diarrhea and chicken colibacillosis more effective.
3, in Chinese medicine composition of the present invention, each component cooperatively interacts, and complements each other, and synergism makes it have obvious therapeutical effect to piglet diarrhea and chicken colibacillosis.
Adopt dual-effect concentrator can retain effective ingredient in Chinese medicine better in the preparation method of 4, the present composition, drug level is high, and medical value is higher.
Accompanying drawing explanation
Fig. 1 is that embodiment 1 obtains the solution of medicine and the fungistatic effect figure of other antibiotic medicines.
Fig. 2 is the fungistatic effect figure of embodiment 1 when obtaining medicine variable concentrations.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is specifically described.
Embodiment 1
Treat a preparation method for the Chinese medicine composition of piglet diarrhea and chicken colibacillosis, comprise the steps:
(1) Herba Taraxaci 26 parts, Herba Violae 26 parts, Flos Chrysanthemi Indici 23 parts, Herba Hedyotidis Diffusae 25 parts is taken respectively;
(2), after being mixed by the raw material taken, add the hot water (temperature is 70 DEG C) of raw material gross weight 10 times, heated and boiled 3 hours, filters to get filtrate and filtering residue;
(3) add the hot water (temperature is 80 DEG C) of gross weight 9 times in the filtering residue obtained to step (2), heated and boiled 2.5 hours, filter and obtain filtrate and filtering residue;
(4) filtrate of combining step (2) and step (3) gained, natural cooling, and concentrated to reach density be 1.16; Described concentration process adopts dual-effect concentrator, and wherein, an effect vacuum and evaporating temperature are :-0.05MPa, 85 DEG C; Two effect vacuums and evaporating temperature are :-0.06MPa, 75 DEG C;
(5) concentrated solution is evacuated in spray dryer (inlet temperature is 140 DEG C, and leaving air temp is 70 DEG C) carry out spray do, obtain Powdered finished product.
Embodiment 2
Treat a preparation method for the Chinese medicine composition of piglet diarrhea and chicken colibacillosis, comprise the steps:
(1) Herba Taraxaci 25 parts, Herba Violae 25 parts, Flos Chrysanthemi Indici 25 parts, Herba Hedyotidis Diffusae 25 parts is taken respectively;
(2), after being mixed by the raw material taken, add the hot water (temperature is 80 DEG C) of raw material gross weight 12 times, heated and boiled 3 hours, filters to get filtrate and filtering residue;
(3) add the hot water (temperature is 80 DEG C) of gross weight 10 times in the filtering residue obtained to step (2), heated and boiled 2.5 hours, filter and obtain filtrate and filtering residue;
(4) filtrate of combining step (2) and step (3) gained, natural cooling, and concentrated to reach density be 1.15; Described concentration process adopts dual-effect concentrator, and wherein, an effect vacuum and evaporating temperature are :-0.04MPa, 85 DEG C; Two effect vacuums and evaporating temperature are :-0.10MPa, 75 DEG C;
(5) concentrated solution is evacuated in spray dryer (inlet temperature is 150 DEG C, and leaving air temp is 80 DEG C) carry out spray do, obtain Powdered finished product.
Embodiment 3
Treat a preparation method for the Chinese medicine composition of piglet diarrhea and chicken colibacillosis, comprise the steps:
(1) Herba Taraxaci 23 parts, Herba Violae 24 parts, Flos Chrysanthemi Indici 26 parts, Herba Hedyotidis Diffusae 27 parts is taken respectively;
(2), after being mixed by the raw material taken, add the hot water (temperature is 90 DEG C) of raw material gross weight 11 times, heated and boiled 3 hours, filters to get filtrate and filtering residue;
(3) add the hot water (temperature is 80 DEG C) of gross weight 9 times in the filtering residue obtained to step (2), heated and boiled 2.5 hours, filter and obtain filtrate and filtering residue;
(4) filtrate of combining step (2) and step (3) gained, natural cooling, and concentrated to reach density be 1.12; Described concentration process adopts dual-effect concentrator, and wherein, an effect vacuum and evaporating temperature are :-0.07MPa, 85 DEG C; Two effect vacuums and evaporating temperature are :-0.08MPa, 75 DEG C;
(5) concentrated solution is evacuated in spray dryer (inlet temperature is 160 DEG C, and leaving air temp is 90 DEG C) carry out spray do, obtain Powdered finished product.
Test case:
Escherichia coli are seeded in suitable culture medium, adopt steel pipe method (pipe diameter 7.8mm) in culture medium, introduce the obtained drug solution of the embodiment of the present invention 1 and other antibiotic medicines, as shown in Figure 1, 2.
As can be seen from Figure 1, the colistin of low concentration, oligo-chitosan, scutellaria detoxification powder and medicine of the present invention do not affect bacterial growth, when increasing drug level, can find out that oligo-chitosan and medicine of the present invention have obvious inhibitory action to escherichia coli, defining inhibition zone.
On Escherichia coli culture medium, introduce the solution of the embodiment 1 gained medicine of variable concentrations in Fig. 2, medicine stock solution is diluted 5,10,20,50 times respectively, and as can be seen from the figure, concentration is larger, and the inhibition zone of formation is larger, illustrates that fungistatic effect is better.
Above-described is only the preferred embodiment of the present invention, the invention is not restricted to above embodiment.Be appreciated that the oher improvements and changes that those skilled in the art directly derive without departing from the spirit and concept in the present invention or associate, all should think and be included within protection scope of the present invention.
Claims (6)
1. treat a Chinese medicine composition for piglet diarrhea and chicken colibacillosis, it is characterized in that described Chinese medicine composition is the medicament that the raw material of Chinese medicine of following weight proportioning is made:
Herba Taraxaci 23 ~ 27 parts, Herba Violae 23 ~ 27 parts, Flos Chrysanthemi Indici 23 ~ 27 parts, Herba Hedyotidis Diffusae 23 ~ 27 parts.
2. Chinese medicine composition according to claim 1, is characterized in that described medicament is powder.
3. a preparation method for Chinese medicine composition described in claim 1, is characterized in that comprising the steps: that (1) takes Herba Taraxaci 23 ~ 27 parts, Herba Violae 23 ~ 27 parts, Flos Chrysanthemi Indici 23 ~ 27 parts, Herba Hedyotidis Diffusae 23 ~ 27 parts respectively;
(2), after being mixed by the raw material taken, add the hot water of raw material gross weight 10 ~ 12 times, heated and boiled 3 hours, filters to get filtrate and filtering residue;
(3) add the hot water of gross weight 8 ~ 10 times in the filtering residue obtained to step (2), heated and boiled 2.5 hours, filter and obtain filtrate and filtering residue;
(4) filtrate of combining step (2) and step (3) gained, natural cooling, and concentrated to reach density be 1.1 ~ 1.2; (5) concentrated solution is evacuated in spray dryer carry out spray do, obtain Powdered finished product.
4. preparation method according to claim 3, is characterized in that the temperature of hot water in described step (2) and step (3) is 70 ~ 90 DEG C.
5. preparation method according to claim 3, is characterized in that in described step (4), concentration process adopts dual-effect concentrator, and wherein, an effect vacuum and evaporating temperature are :-0.04 ~-0.07MPa, 85 DEG C; Two effect vacuums and evaporating temperature are :-0.06 ~-0.10MPa, 75 DEG C.
6. preparation method according to claim 3, parameters when it is characterized in that spray dryer work in described step (5) is: inlet temperature is 140 ~ 160 DEG C, and leaving air temp is 70 ~ 90 DEG C.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177221A (en) * | 2016-08-18 | 2016-12-07 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for treating swine escherichia coli diarrhoea and preparation method thereof |
| CN106491978A (en) * | 2016-12-09 | 2017-03-15 | 河池市技术开发中心 | A kind of Chinese medicine composition for treating chicken son's diarrhoeal diseases and preparation method thereof |
| CN106620430A (en) * | 2016-12-09 | 2017-05-10 | 河池市技术开发中心 | Traditional Chinese medicine composition used for treating piglet diarrhea and preparation method thereof |
| CN108771726A (en) * | 2018-07-16 | 2018-11-09 | 南京农业大学 | A kind of Chinese medicine compound prescription and its preparation process of prevention livestock and poultry diarrhea |
| CN111011628A (en) * | 2019-12-19 | 2020-04-17 | 何先清 | Plant extract and preparation method and application thereof |
| CN111449173A (en) * | 2019-12-19 | 2020-07-28 | 何先清 | Plant extract and preparation method and application thereof |
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| CN103070944A (en) * | 2013-01-22 | 2013-05-01 | 无锡正大畜禽有限公司 | Chinese medicinal composition for preventing and treating dam postpartum syndrome and preparation method thereof |
| CN103690691A (en) * | 2012-09-27 | 2014-04-02 | 张彦录 | Chinese medicinal composition for preventing and treating livestock and poultry diseases |
| CN103784615A (en) * | 2012-10-31 | 2014-05-14 | 天津生机集团股份有限公司 | Traditional Chinese medicine powder for controlling livestock heatstroke fever and preparation method thereof |
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Patent Citations (4)
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN103690691A (en) * | 2012-09-27 | 2014-04-02 | 张彦录 | Chinese medicinal composition for preventing and treating livestock and poultry diseases |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177221A (en) * | 2016-08-18 | 2016-12-07 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for treating swine escherichia coli diarrhoea and preparation method thereof |
| CN106177221B (en) * | 2016-08-18 | 2020-06-05 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for treating porcine colibacillosis diarrhea and preparation method thereof |
| CN106491978A (en) * | 2016-12-09 | 2017-03-15 | 河池市技术开发中心 | A kind of Chinese medicine composition for treating chicken son's diarrhoeal diseases and preparation method thereof |
| CN106620430A (en) * | 2016-12-09 | 2017-05-10 | 河池市技术开发中心 | Traditional Chinese medicine composition used for treating piglet diarrhea and preparation method thereof |
| CN108771726A (en) * | 2018-07-16 | 2018-11-09 | 南京农业大学 | A kind of Chinese medicine compound prescription and its preparation process of prevention livestock and poultry diarrhea |
| CN108771726B (en) * | 2018-07-16 | 2021-05-28 | 南京农业大学 | Traditional Chinese medicine compound for preventing and treating livestock and poultry diarrhea and preparation process thereof |
| CN111011628A (en) * | 2019-12-19 | 2020-04-17 | 何先清 | Plant extract and preparation method and application thereof |
| CN111449173A (en) * | 2019-12-19 | 2020-07-28 | 何先清 | Plant extract and preparation method and application thereof |
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Application publication date: 20150610 |