CN104688711B - A kind of phyteral Capsules and preparation method thereof - Google Patents
A kind of phyteral Capsules and preparation method thereof Download PDFInfo
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- CN104688711B CN104688711B CN201510103152.9A CN201510103152A CN104688711B CN 104688711 B CN104688711 B CN 104688711B CN 201510103152 A CN201510103152 A CN 201510103152A CN 104688711 B CN104688711 B CN 104688711B
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Abstract
The invention discloses a kind of phyteral Capsules and preparation method thereof.A kind of phyteral Capsules is found out by substantial amounts of research repeatedly to be mainly made up of starch and the raw material such as optional starch derivatives and the water of surplus, and the other materials of phyteral Capsules raw material weight 2% are may further include not greater than in above-mentioned phyteral glue Capsules.Safety is prepared by regulation parameter repeatedly and control condition using existing technique, pollution-free, steady quality, yield is high, wide material sources are with low cost, be applicable crowd extensively, meet 2010 editions《Chinese Pharmacopoeia》Probability reaches the other plant hollow capsule of commercial grade in standard and capsule.
Description
Technical field
Food, medicine, the phyteral Capsules of health products trade and its preparation are can be widely used for the present invention relates to one kind.
Background technology
Current most of its shell of commercially available capsule is gelatin hollow capsule, and the moisture of gelatin is high, and hygroscopicity is strong,
Poor compatibility, be easily caused drug quality it is unqualified and shorten the term of validity, have in addition specific religious belief people also limit it is bright
The use of glue capsule, and as developed countries people health care consciousness is improved, praise highly " green and healthy food ", particularly companion
With spreading and recently caused by " toxic capsule " event of domestic report for the animal sexually transmitted disease such as European " rabid ox disease ", " aftosa "
Fear also forces the popular substitute-plant hollow capsule for starting to consider animality capsule.
Have many patent reports on vegetalitas capsule, such as CN1687203A at present, the patent point out its with starch or
Converted starch is primary raw material by adding necessary plasticizer and gel is used as glue and manufactures capsule.
CN1931145A, the patent points out that its film-forming composition is 5-10 parts of starch, and 0-3 parts of glycerine, 0-7 parts of water passes through
Existing technique prepares capsule, but time-consuming the colloidal sol described in the patent.
But the other materials in addition to starch are with the addition of in above-mentioned patent, are not accomplished " green " truly
" pure natural ".
The content of the invention
The present invention is for current capsule the problem of exist, a kind of brand-new without any addition, safer full shallow lake of proposition
The Capsules of powder, using existing production technology, by controlling parameter and working condition in production process, to obtain quality
Full starch hollow capsule up to standard.
To achieve the above object, concrete scheme of the invention is：
A kind of phyteral Capsules, including starch and the raw material system such as optional starch derivatives and the water of surplus are provided
Be 35%-55% into, it is characterised in that the mass fraction of starch, the mass fraction of optional starch derivatives for 0%-4% with it is remaining
The water of amount；
The mass fraction of wherein starch is preferably 36%, 38%, 40%, 42%, 45%, 47%, 50%, 52%.
The mass fraction of wherein starch derivatives is preferably 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%.
Described starch is selected from cereal, potato class, beans, one kind of fruits and vegetables class or combination；Starch derivatives is selected from etherificate and formed sediment
One kind or combination in powder, esterification starch, oxidized starch, nanometer starch crystal, crosslinked starch.Etherification starch may be selected from hydroxypropyl shallow lake
Powder, HES and hydroxymethyl starch；Esterification starch may be selected from phosphate ester starch, acetate starch, starch sulfate；Starch
The preferred esterification starch of derivative and/or oxidized starch, the oxidation of further preferred 2%-8% esterification starch and 92%-98%
Starch.
According to demand, phyteral Capsules may also include the total of gelling agent, plasticizer, food coloring, and these materials
Weight is no more than the 2% of phyteral Capsules raw material gross weight.Applicant through testing repeatedly, in the situation without any addition
Under, it is determined that the composition of phyteral Capsules raw material of the invention is only, starch and optional starch derivatives and the water of surplus.
By controlling corresponding condition and parameter in production process to prepare phyteral Capsules.
Another aspect of the present invention there is provided a kind of preparation method for preparing the phyteral Capsules, including molten
Glue, embryo processed is cut, screening, fit, lamp inspection, the step such as total inspection, and is colloidal sol and embryo processed the step of prepare capsule most critical,
The present invention is characterised by colloidal sol this step, first adds starch and optional starch derivative toward adding hot water in glue pot
Thing, is incubated a period of time after heating, bubble removing finally filters standby in heat-preserving container；It is characterised by this step of embryo processed, works as glue
Capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into the top stop regular hour, then turnover panel is for several times；Capsule body dips in offset plate and dipped in
After gum forming, offset plate will be dipped in and be pushed into top stop certain time, afterwards turn over for several times, finally dry.
Further, to make to obtain the hot water temperature added in the homogeneous glue of quality, colloidal sol step at 30-40 DEG C, so
The optional starch that the starch and mass fraction that addition mass fraction is 35-55% under conditions of stirring afterwards are 0-5% derives
50-65 DEG C is warming up to after thing, 10-20min is stirred at this temperature, then 75-100 DEG C is warming up to 1-2 DEG C/min speed, most
Stir 50-100min at this temperature afterwards.Aperture of filter screen makes it in 100-300 mesh in colloidal sol this step, and mixing speed is
100-200r/min.It should be noted that under other apertures and mixing speed, can also obtain phyteral Capsules, simply
Obtained phyteral Capsules in outward appearance and quality and imperfections.
Applicant will obtain wall thickness, top thickness and the thick homogeneous phyteral Capsules of arc, most critical through testing discovery repeatedly
In addition to colloidal sol step, embryo processed is also a very crucial step, so further, in embryo step processed, capsule cap dips in offset plate
Dip in after gum forming, capsule board is pushed into top stops 0.001-8s, and fan is installed in top lower section makes its rapid draing, then turnover panel
1-5 times；Capsule body dips in offset plate and dipped in after gum forming, is pushed into top and stops 0.001-8s, fan is installed in top lower section makes its fast
Rapid-curing cutback is dry, then turnover panel 1-5 times.It is the glue rapid shaping in order that after dipping in glue that fan is installed below top, so as to avoid
Moulding dose of addition.
In embryo step processed, drying temperature, humidity and time also have a significant impact to obtained capsule quality, can mainly influence
The friability of capsule, so further, temperature when controlling to dry is 25-35 DEG C, humidity 35-65%, time 1-2h.Pass through control
Condition and parameter during capsule manufacture processed, make the wall thickness of capsule cap of obtained phyteral Capsules in 85 μm of -130 μ
M, 150 μm -220 μm of top thickness, arc thickness is more than 80 μm；The wall thickness of capsule body is in 85 μm -130 μm, 150 μm -220 μm of top thickness, arc
Thickness is more than 80 μm.
The beneficial effects of the present invention are：Can only with full starch without adding gelling agent, plasticizer etc. on the basis of
By controlling corresponding parameter and condition to prepare full starch hollow capsule, and starch source is extensively, without any side effects, valency
Lattice are cheap, can create bigger profit.
Specific embodiment
Embodiments of the invention are described below in detail, these embodiments are intended to be used to explain the present invention, and it is not intended that
Limitation of the present invention.
Embodiment 1
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 100r/min to be
35% cereal starch, adds the water of surplus, rises to and 10min is stirred after 50 DEG C, then be warming up to 100 with 1 DEG C/min speed
50min is stirred after DEG C, bubble removing is depressurized, the filter screen for crossing 300 mesh is stand-by into heat-preserving container.The temperature for treating glue in heat-preserving container is
Gluing after 60 DEG C, capsule cap dips in offset plate and dipped in after gum forming, will dip in after offset plate is pushed into top stop 1s and overturns 180 ° in 25 DEG C, 40%
Relative humidity under dry 1h, capsule body dips in offset plate and dips in after gum forming, will dip in offset plate and is pushed into top and stops after 2s first to turn over clockwise
Turn 360 ° of another mistake hour hands and overturn 180 °, 1h is dried under 25 DEG C, 40% relative humidity, then cleaved, screening, fit, lamp
Inspection, obtains Capsules, after tested, the indices of Capsules are at 2010 editions after total inspection《Chinese Pharmacopoeia》Critical field
It is interior.Carry out capsule filling experiment.
Embodiment 2
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 150r/min to be
55% potato starch, adds the water of surplus, rises to and 10min is stirred after 55 DEG C, then be warming up to 75 DEG C with 1 DEG C/min speed
After stir 50min, depressurize bubble removing, the filter screen for crossing 200 mesh is stand-by into heat-preserving container.The temperature for treating glue in heat-preserving container is 60
Gluing after DEG C, capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into top and stops after 1s 180 ° of upset at 25 DEG C, 40%
1h is dried under relative humidity, capsule body dips in offset plate and dipped in after gum forming, offset plate will be dipped in and be pushed into first upset clockwise after top stop 2s
360 ° of another mistake hour hands overturn 180 °, and 1h is dried under 25 DEG C, 40% relative humidity, then cleaved, screening, fit, lamp inspection,
Capsules is obtained after total inspection, after tested, the indices of Capsules are at 2010 editions《Chinese Pharmacopoeia》In critical field.Enter
The filling experiment of row capsule.
Embodiment 3
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 200r/min to be
37% bean starch, 4% acetate starch adds the water of surplus, rises to and 10min is stirred after 65 DEG C, then with 1 DEG C/min
Speed be warming up to after 95 DEG C and stir 50min, depressurize bubble removing, the filter screen for crossing 100 mesh is stand-by into heat-preserving container.Treat heat-preserving container
The temperature of middle glue is gluing after 60 DEG C, and capsule cap dips in offset plate and dipped in after gum forming, will dip in after offset plate is pushed into top stop 1s and overturns
180°.1h is dried under 25 DEG C, 40% relative humidity, capsule body dips in offset plate and dip in after gum forming, offset plate will be dipped in be pushed into top and stop
First 360 ° of 180 ° of another mistake hour hands upsets of upset clockwise after 2s are stayed, 1h are dried under 25 DEG C, 40% relative humidity, then through cutting
Cut, screen, fit, lamp inspection, obtain Capsules after total inspection, after tested, the indices of Capsules are at 2010 editions《China
Pharmacopeia》In critical field.Carry out capsule filling experiment.
Embodiment 4
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 100r/min to be
36% cereal starch, adds the water of surplus, rises to and 10min is stirred after 65 DEG C, then be warming up to 85 DEG C with 1 DEG C/min speed
After stir 50min, depressurize bubble removing, the filter screen for crossing 200 mesh is stand-by into heat-preserving container.The temperature for treating glue in heat-preserving container is 60
Gluing after DEG C, capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into top and stops after 1s 180 ° of upset at 25 DEG C, 40%
1h is dried under relative humidity, capsule body dips in offset plate and dipped in after gum forming, offset plate will be dipped in and be pushed into first upset clockwise after top stop 2s
360 ° of another mistake hour hands overturn 180 °, and 1h is dried under 25 DEG C, 40% relative humidity, then cleaved, screening, fit, lamp inspection,
Capsules is obtained after total inspection, after tested, the indices of Capsules are at 2010 editions《Chinese Pharmacopoeia》In critical field.Enter
The filling experiment of row capsule.
Embodiment 5
Added into glue pot after 35 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 150r/min to be
38% potato starch, 0.1% hydroxypropul starch and the water of surplus, rise to and 15min are stirred after 50 DEG C, then with 1 DEG C/min's
Speed, which is warming up to after 100 DEG C, stirs 75min, depressurizes bubble removing, and the filter screen for crossing 300 mesh is stand-by into heat-preserving container.Treat heat-preserving container
The temperature of middle glue is gluing after 70 DEG C, and capsule cap dips in offset plate and dip in after gum forming, will dip in offset plate and is pushed into top and overturns clockwise
180 ° are pushed into rear chamber and 1.5h are dried under 30 DEG C, 50% relative humidity, and capsule body dips in offset plate and dipped in after gum forming, will dip in offset plate and push away
First 360 ° of 180 ° of another mistake hour hands upsets of upset clockwise after 2s are stopped to top, are dried under 30 DEG C, 50% relative humidity
1.5h, then cleaved, screening, fit, lamp inspection obtains Capsules, after tested, the indices of Capsules are equal after total inspection
At 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Embodiment 6
Added into glue pot after 35 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 150r/min to be
38% potato starch, 0.5% oxidized starch and the water of surplus, rise to and 15min are stirred after 60 DEG C, then with 1 DEG C/min speed
Degree, which is warming up to after 85 DEG C, stirs 75min, depressurizes bubble removing, and the filter screen for crossing 300 mesh is stand-by into heat-preserving container.Treat glue in heat-preserving container
The temperature of liquid is gluing after 70 DEG C, and capsule cap dips in offset plate and dip in after gum forming, will dip in offset plate and is pushed into top 180 ° of upset is pushed away clockwise
1.5h is dried under 30 DEG C, 50% relative humidity to rear chamber, capsule body dips in offset plate and dipped in after gum forming, will dip in offset plate and be pushed into top
First 360 ° of 180 ° of another mistake hour hands upsets of upset clockwise after 2s are stopped, 1.5h are dried under 30 DEG C, 50% relative humidity, then
Cleaved, screening, fit, lamp inspection obtains Capsules, after tested, the indices of Capsules are at 2010 editions after total inspection
《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Embodiment 7
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 200r/min to be
40% potato starch, 1.5% starch sulfate and the water of surplus, rise to and 20min are stirred after 65 DEG C, then with 1.5 DEG C/min
Speed be warming up to after 89 DEG C and stir 74min, depressurize bubble removing, the filter screen for crossing 200 mesh is stand-by into heat-preserving container.Treat heat-preserving container
The temperature of middle glue is gluing after 100 DEG C, and capsule cap dips in offset plate and dip in after gum forming, will dip in offset plate be pushed into top stop it is suitable after 0.5s
Hour hands overturn 180 ° and 2h are dried under 25 DEG C, 40% relative humidity in 180 ° of pushers of upset counterclockwise to rear chamber, and capsule body is dipped in
Offset plate is dipped in after gum forming, will be dipped in offset plate and is pushed into after top stop 2s first the up times again of 180 ° of 180 ° of another mistake hour hands upsets of upset clockwise
Pin overturns 180 °, and then cleaved, screening, fit, lamp inspection obtains Capsules after total inspection, after tested, the items of Capsules
Index is at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Embodiment 8
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 200r/min to be
42% potato starch, 2.5% HES and the water of surplus, rise to and 20min are stirred after 65 DEG C, then with 1.5 DEG C/min
Speed be warming up to after 98 DEG C and stir 85min, depressurize bubble removing, the filter screen for crossing 200 mesh is stand-by into heat-preserving container.Treat heat-preserving container
The temperature of middle glue is gluing after 100 DEG C, and capsule cap dips in offset plate and dip in after gum forming, will dip in offset plate be pushed into top stop it is suitable after 0.5s
Hour hands overturn 180 ° and 2h are dried under 25 DEG C, 40% relative humidity in 180 ° of pushers of upset counterclockwise to rear chamber, and capsule body is dipped in
Offset plate is dipped in after gum forming, will be dipped in offset plate and is pushed into after top stop 2s first the up times again of 180 ° of 180 ° of another mistake hour hands upsets of upset clockwise
Pin overturns 180 °, and then cleaved, screening, fit, lamp inspection obtains Capsules after total inspection, after tested, the items of Capsules
Index is at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Embodiment 9
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 200r/min to be
45% potato starch, 3% crosslinked starch and the water of surplus, rise to and 20min are stirred after 65 DEG C, then with 1.5 DEG C/min speed
Degree, which is warming up to after 94 DEG C, stirs 96min, depressurizes bubble removing, and the filter screen for crossing 200 mesh is stand-by into heat-preserving container.Treat glue in heat-preserving container
The temperature of liquid is gluing after 100 DEG C, and capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into after top stop 0.5s clockwise
180 ° of upset dries 2h in 180 ° of pushers of upset counterclockwise to rear chamber under 25 DEG C, 40% relative humidity, and capsule body dips in offset plate
Dip in after gum forming, offset plate will be dipped in and be pushed into top and stop after 2s first 180 ° of another mistake hour hands of upset clockwise and overturn 180 ° to turn over clockwise again
Turn 180 °, then cleaved, screening, fit, lamp inspection obtains Capsules after total inspection, after tested, the indices of Capsules
At 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Embodiment 10
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 200r/min to be
47% bean starch, 2% phosphate ester starch and the water of surplus, rise to and 20min are stirred after 65 DEG C, then with 1.5 DEG C/min's
Speed, which is warming up to after 86 DEG C, stirs 70min, depressurizes bubble removing, and the filter screen for crossing 200 mesh is stand-by into heat-preserving container.Treat in heat-preserving container
The temperature of glue is gluing after 100 DEG C, and capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into up time after top stop 0.5s
Pin overturns 180 ° and 2h is dried under 25 DEG C, 40% relative humidity in 180 ° of pushers of upset counterclockwise to rear chamber, and capsule body dips in glue
Plate is dipped in after gum forming, will dip in offset plate be pushed into top stop after 2s first 180 ° of another mistake hour hands of upset clockwise overturn 180 ° it is clockwise again
180 ° of upset, then cleaved, screening, fit, lamp inspection obtains Capsules, after tested, the items of Capsules refer to after total inspection
Mark is at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Embodiment 11
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 200r/min to be
50% cereal starch, 3% hydroxymethyl starch and the water of surplus, rise to and 20min are stirred after 65 DEG C, then with 1.5 DEG C/min's
Speed, which is warming up to after 89 DEG C, stirs 80min, depressurizes bubble removing, and the filter screen for crossing 200 mesh is stand-by into heat-preserving container.Treat in heat-preserving container
The temperature of glue is gluing after 100 DEG C, and capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into up time after top stop 0.5s
Pin overturns 180 ° and 2h is dried under 25 DEG C, 40% relative humidity in 180 ° of pushers of upset counterclockwise to rear chamber, and capsule body dips in glue
Plate is dipped in after gum forming, will dip in offset plate be pushed into top stop after 2s first 180 ° of another mistake hour hands of upset clockwise overturn 180 ° it is clockwise again
180 ° of upset, then cleaved, screening, fit, lamp inspection obtains Capsules, after tested, the items of Capsules refer to after total inspection
Mark is at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Embodiment 12
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 200r/min to be
52% fruits and vegetables kind of starch, 2.0% acetate starch and the water of surplus, rise to and 20min are stirred after 65 DEG C, then with 1.5 DEG C/
Min speed, which is warming up to after 79 DEG C, stirs 75min, depressurizes bubble removing, and the filter screen for crossing 200 mesh is stand-by into heat-preserving container.Wait to protect
The temperature of glue is gluing after 100 DEG C in warm bucket, and capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into top stop 0.5s
180 ° of upset dries 2h, capsule in 180 ° of pushers of upset counterclockwise to rear chamber under 25 DEG C, 40% relative humidity clockwise afterwards
Body dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into after top stop 2s first 180 ° of 180 ° of another mistake hour hands upsets of upset clockwise again
180 ° of upset, then cleaved clockwise, screening, fit, lamp inspection, and Capsules, after tested, Capsules are obtained after total inspection
Indices are at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Embodiment 13
Added into glue pot after 35 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 150r/min to be
(esterification starch is 5%, oxygen wherein in the mixture of the starch derivatives for 45% potato starch, 2% esterification and oxidized starch
It is 95% to change starch, and esterification starch may be selected from phosphate ester starch, acetate starch, starch sulfate；) and surplus water,
Rise to and 15min is stirred after 60 DEG C, then be warming up to 1 DEG C/min speed after 100 DEG C and stir 75min, depressurize bubble removing, cross 300
Purpose filter screen is stand-by into heat-preserving container.After glue in heat-preserving container temperature be 70 DEG C after gluing, capsule cap dip in offset plate dip in glue into
After type, will dip in offset plate be pushed into top clockwise upset 180 ° be pushed into rear chamber under 30 DEG C, 50% relative humidity dry 1.5h, glue
Utricule dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into after top stop 2s first 360 ° of another mistake hour hands upsets of upset clockwise
180 °, 1.5h is dried under 30 DEG C, 50% relative humidity, then cleaved, screening, fit, lamp inspection obtains hollow after total inspection
Capsule, after tested, the indices of Capsules are at 2010 editions《Chinese Pharmacopoeia》In critical field.Capsule is carried out to fill
Test.
Comparative example 1
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 300r/min to be
35% starch, adds the water of surplus, rises to and 20min is stirred after 65 DEG C, then be warming up to 1.5 DEG C/min speed after 80 DEG C
100min is stirred, bubble removing is depressurized, the filter screen for crossing 100 mesh is stand-by into heat-preserving container.The temperature for treating glue in heat-preserving container is 100
Gluing after DEG C, capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into after top stop 0.5s 180 ° of upset clockwise inverse
Hour hands overturn 180 ° of pushers to rear chamber and 2h are dried under 25 DEG C, 40% relative humidity, and capsule body dips in offset plate and dipped in after gum forming, will
Dip in offset plate and be pushed into after top stop 2s first 180 ° of 180 ° of another mistake hour hands upsets of upset, 180 ° of upset clockwise, Ran Houjing again clockwise
Cutting, screening, fit, lamp inspection obtains Capsules, after tested, the indices of Capsules are not at 2010 editions after total inspection
《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Comparative example 2
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 150r/min to be
37% starch and 0.8% acetate starch add the water of surplus, rise to and 20min is stirred after 65 DEG C, then with 1-2 DEG C/min
Speed be warming up to after 120 DEG C and stir 100min, depressurize bubble removing, the filter screen for crossing 400 mesh is stand-by into heat-preserving container.Wait to be incubated
The temperature of glue is gluing after 100 DEG C in bucket, and capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into after top stop 0.5s
180 ° of upset dries 2h, capsule body in 180 ° of pushers of upset counterclockwise to rear chamber under 25 DEG C, 40% relative humidity clockwise
Offset plate is dipped in dip in after gum forming, will dip in offset plate be pushed into top stop after 2s first 180 ° of another mistake hour hands of upset clockwise overturn 180 ° it is suitable again
Hour hands overturn 180 °, and then cleaved, screening, fit, lamp inspection obtains Capsules after total inspection, after tested, Capsules it is each
Item index is not at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Comparative example 3
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 100r/min to be
55% starch adds the water of surplus, rises to and 20min is stirred after 65 DEG C, then stirs after being warming up to 100 DEG C with 1 DEG C/min speed
100min is mixed, bubble removing is depressurized, the filter screen for crossing 400 mesh is stand-by into heat-preserving container.The temperature for treating glue in heat-preserving container is 100 DEG C
Gluing afterwards, capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into after top stop 0.5s 180 ° of upset clockwise in the inverse time
Pin overturns 180 ° of pushers to rear chamber and 2h is dried under 25 DEG C, 40% relative humidity, and capsule body dips in offset plate and dipped in after gum forming, will dip in
Offset plate is pushed into top and stops first 180 ° of 180 ° of another mistake hour hands upsets of upset, 180 ° of upset clockwise again clockwise after 2s, then through cutting
Cut, screen, fit, lamp inspection, obtain Capsules after total inspection, after tested, the indices of Capsules are not at 2010 editions《In
State's pharmacopeia》In critical field.Carry out capsule filling experiment.
Comparative example 4
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 50r/min to be
35% starch adds the water of surplus, rises to and 20min is stirred after 65 DEG C, then stirs after being warming up to 100 DEG C with 1 DEG C/min speed
100min is mixed, bubble removing is depressurized, the filter screen for crossing 400 mesh is stand-by into heat-preserving container.The temperature for treating glue in heat-preserving container is 100 DEG C
Gluing afterwards, capsule cap dips in offset plate and dipped in after gum forming, will dip in offset plate and is pushed into after top stop 0.5s 180 ° of upset clockwise in the inverse time
Pin overturns 180 ° of pushers to rear chamber and 2h is dried under 25 DEG C, 40% relative humidity, and capsule body dips in offset plate and dipped in after gum forming, will dip in
Offset plate is pushed into top and stops first 180 ° of 180 ° of another mistake hour hands upsets of upset, 180 ° of upset clockwise again clockwise after 2s, then through cutting
Cut, screen, fit, lamp inspection, obtain Capsules after total inspection, after tested, the indices of Capsules are not at 2010 editions《In
State's pharmacopeia》In critical field.Carry out capsule filling experiment.
Comparative example 5
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 50r/min to be
55% starch, 0.9% nanometer starch crystal adds the water of surplus, rises to and 20min is stirred after 65 DEG C, then with 1-2 DEG C/min's
Speed, which is warming up to after 100 DEG C, stirs 100min, depressurizes bubble removing, and the filter screen for crossing 400 mesh is stand-by into heat-preserving container.Treat heat-preserving container
The temperature of middle glue is gluing after 100 DEG C, and capsule cap dips in offset plate and dip in after gum forming, will dip in offset plate be pushed into top stop it is suitable after 0.5s
Hour hands overturn 180 ° and 2h are dried under 25 DEG C, 40% relative humidity in 180 ° of pushers of upset counterclockwise to rear chamber, and capsule body is dipped in
Offset plate is dipped in after gum forming, will be dipped in offset plate and is pushed into after top stop 2s first the up times again of 180 ° of 180 ° of another mistake hour hands upsets of upset clockwise
Pin overturns 180 °, and then cleaved, screening, fit, lamp inspection obtains Capsules after total inspection, after tested, the items of Capsules
Index is not at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Comparative example 6
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 50r/min to be
41% starch, 1.3% nanometer starch crystal adds the water of surplus, rises to and 20min is stirred after 65 DEG C, then with 1-2 DEG C/min's
Speed, which is warming up to after 120 DEG C, stirs 100min, depressurizes bubble removing, and the filter screen for crossing 400 mesh is stand-by into heat-preserving container.Treat heat-preserving container
The temperature of middle glue is gluing after 100 DEG C, and capsule cap dips in offset plate and dip in after gum forming, will dip in offset plate be pushed into top stop it is suitable after 0.5s
Hour hands overturn 180 ° and 2h are dried under 25 DEG C, 40% relative humidity in 180 ° of pushers of upset counterclockwise to rear chamber, and capsule body is dipped in
Offset plate is dipped in after gum forming, will be dipped in offset plate and is pushed into after top stop 2s first the up times again of 180 ° of 180 ° of another mistake hour hands upsets of upset clockwise
Pin overturns 180 °, and then cleaved, screening, fit, lamp inspection obtains Capsules after total inspection, after tested, the items of Capsules
Index is not at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Comparative example 7
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 50r/min to be
40% starch, 1.5% nanometer starch crystal adds the water of surplus, rises to and 20min is stirred after 65 DEG C, then with 1-2 DEG C/min's
Speed, which is warming up to after 120 DEG C, stirs 100min, depressurizes bubble removing, and the filter screen for crossing 200 mesh is stand-by into heat-preserving container.Treat heat-preserving container
The temperature of middle glue is gluing after 100 DEG C, and capsule cap dips in offset plate and dip in after gum forming, will dip in offset plate be pushed into top stop it is suitable after 0.5s
Hour hands overturn 180 ° and 2h are dried under 25 DEG C, 40% relative humidity in 180 ° of pushers of upset counterclockwise to rear chamber, and capsule body is dipped in
Offset plate is dipped in after gum forming, will be dipped in offset plate and is pushed into after top stop 2s first the up times again of 180 ° of 180 ° of another mistake hour hands upsets of upset clockwise
Pin overturns 180 °, and then cleaved, screening, fit, lamp inspection obtains Capsules after total inspection, after tested, the items of Capsules
Index is not at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Comparative example 8
Added into glue pot after 30 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 50r/min to be
40% starch, 1.5% nanometer starch crystal adds the water of surplus, rises to and 20min is stirred after 65 DEG C, then with 1-2 DEG C/min's
Speed, which is warming up to after 120 DEG C, stirs 100min, depressurizes bubble removing, and the filter screen for crossing 400 mesh is stand-by into heat-preserving container.Treat heat-preserving container
The temperature of middle glue is gluing after 100 DEG C, and capsule cap dips in offset plate and dip in after gum forming, will dip in offset plate be pushed into top stop it is suitable after 0.5s
Hour hands overturn 180 ° and 2h are dried under 25 DEG C, 40% relative humidity in 180 ° of pushers of upset counterclockwise to rear chamber, and capsule body is dipped in
Offset plate is dipped in after gum forming, will be dipped in offset plate and is pushed into after top stop 2s first the up times again of 180 ° of 180 ° of another mistake hour hands upsets of upset clockwise
Pin overturns 180 °, and then cleaved, screening, fit, lamp inspection obtains Capsules after total inspection, after tested, the items of Capsules
Index is not at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Comparative example 9
Added into glue pot after 35 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 200r/min to be
(esterification starch is that 5%, oxidation is formed sediment wherein in the mixture of the starch derivatives for 45% starch, 2% esterification and oxidized starch
Powder is 95%, and esterification starch may be selected from phosphate ester starch, acetate starch, starch sulfate) and surplus water, rise to 60
15min is stirred after DEG C, then is warming up to 1 DEG C/min speed after 120 DEG C and stirs 75min, bubble removing is depressurized, the filter of 400 mesh is crossed
Net is stand-by into heat-preserving container.The gluing after the temperature of glue in heat-preserving container is 70 DEG C, capsule cap dips in offset plate and dipped in after gum forming, will
Dip in offset plate to be pushed into top 180 ° of upset is pushed into rear chamber and dries 1.5h under 30 DEG C, 50% relative humidity clockwise, capsule body dips in
Offset plate is dipped in after gum forming, will be dipped in offset plate and is pushed into after top stop 2s first 360 ° of 180 ° of another mistake hour hands upsets of upset clockwise, 30
DEG C, 1.5h is dried under 50% relative humidity, then cleaved, screening, fit, lamp inspection obtains Capsules, through surveying after total inspection
Examination, the indices of Capsules are not at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Comparative example 10
Added into glue pot after 35 DEG C of hot water, low whipping speed is to add mass fraction under conditions of 300r/min to be
(esterification starch is that 5%, oxidation is formed sediment wherein in the mixture of the starch derivatives for 45% starch, 2% esterification and oxidized starch
Powder is 95%, and esterification starch may be selected from phosphate ester starch, acetate starch, starch sulfate) and surplus water, rise to 60
15min is stirred after DEG C, then is warming up to 1 DEG C/min speed after 120 DEG C and stirs 75min, bubble removing is depressurized, the filter of 400 mesh is crossed
Net is stand-by into heat-preserving container.The gluing after the temperature of glue in heat-preserving container is 70 DEG C, capsule cap dips in offset plate and dipped in after gum forming, will
Dip in offset plate to be pushed into top 180 ° of upset is pushed into rear chamber and dries 1.5h under 30 DEG C, 50% relative humidity clockwise, capsule body dips in
Offset plate is dipped in after gum forming, will be dipped in offset plate and is pushed into after top stop 2s first 360 ° of 180 ° of another mistake hour hands upsets of upset clockwise, 30
DEG C, 1.5h is dried under 50% relative humidity, then cleaved, screening, fit, lamp inspection obtains Capsules, through surveying after total inspection
Examination, the indices of Capsules are not at 2010 editions《Chinese Pharmacopoeia》In critical field.Carry out capsule filling experiment.
Probability is tested on experimental example：
Upper probability：In order to detect capsule during capsule filling machine high speed rotation fit, the performance of capsule.It can reach
To commercially available rank, then when capsule filler is more than 10000, probability is at least 99.99% thereon.
The upper probability result of the various embodiments described above and comparative example see the table below：
Claims (3)
1. a kind of phyteral Capsules, is made up of the water of starch and starch derivatives and surplus, it is characterised in that each material
Mass fraction is：35%-55% starch；0.1-4% starch derivatives；The water of surplus；
Described starch is selected from cereal, potato class, one kind of beans or combination；
The starch derivatives is made up of 2%-8% esterification starch and 92%-98% oxidized starch；
The Capsules is cut using colloidal sol, embryo processed is included, prepared by screening, fit, lamp inspection, always the step of inspection：
In colloidal sol step, water is heated into glue pot, starch and starch derivatives is added, a period of time is incubated after heating, is removed
Bubble, finally filters and glue is obtained in heat-preserving container；
In embryo step processed, capsule cap dips in offset plate and dipped in after glue shaping, is pushed into top, then overturn for several times；Capsule body dips in offset plate and dipped in
After gum forming, offset plate will be dipped in and be pushed into top, afterwards turn over for several times, finally dry；
Wherein in colloidal sol step, 30-40 DEG C of hot water is added, then adds starch and starch derivatives under agitation, 50-65 is risen to
10-20min is stirred after DEG C, then is warming up to 1-2 DEG C/min speed after 75-100 DEG C and stirs 50-100min；
In embryo step wherein processed, capsule cap dips in offset plate and dipped in after gum forming, is pushed into behind top, then stops 0.001-8s, top
Fan is installed in lower section makes its rapid draing, then turnover panel 1-5 times；Capsule body dips in offset plate and dipped in after gum forming, is pushed into behind top,
Stopping installation fan below 0.001-8s, top again makes its rapid draing, then turnover panel 1-5 times；
Aperture of filter screen is 100-300 mesh in colloidal sol step, and mixing speed is 100-200r/min；
In embryo step processed, drying condition is 25-35 DEG C of temperature, humidity 35-65%, time 1-2h.
2. a kind of preparation method of phyteral Capsules according to claim 1, including colloidal sol, embryo processed, cut, sieve
Choosing, fit, lamp inspection always examines step, it is characterised in that：
In colloidal sol step, water is heated into glue pot, starch and starch derivatives is added, a period of time is incubated after heating, is removed
Bubble, finally filters and glue is obtained in heat-preserving container；
In embryo step processed, capsule cap dips in offset plate and dipped in after glue shaping, is pushed into top, then overturn for several times；Capsule body dips in offset plate and dipped in
After gum forming, offset plate will be dipped in and be pushed into top, afterwards turn over for several times, finally dry；
Wherein in colloidal sol step, 30-40 DEG C of hot water is added, then adds starch and starch derivatives under agitation, 50-65 is risen to
10-20min is stirred after DEG C, then is warming up to 1-2 DEG C/min speed after 75-100 DEG C and stirs 50-100min；
In embryo step wherein processed, capsule cap dips in offset plate and dipped in after gum forming, is pushed into behind top, then stops 0.001-8s, top
Fan is installed in lower section makes its rapid draing, then turnover panel 1-5 times；Capsule body dips in offset plate and dipped in after gum forming, is pushed into behind top,
Stopping installation fan below 0.001-8s, top again makes its rapid draing, then turnover panel 1-5 times；
Aperture of filter screen is 100-300 mesh in colloidal sol step, and mixing speed is 100-200r/min；
In embryo step processed, drying condition is 25-35 DEG C of temperature, humidity 35-65%, time 1-2h.
3. preparation method according to claim 2, it is characterised in that the blank of gained controls the wall of its capsule cap after embryo processed
Thickness is at 85 μm -130 μm, and 150 μm -220 μm of top thickness, arc thickness is more than 80 μm；The wall thickness of capsule body is in 85 μm -130 μm, top thickness
150 μm -220 μm, arc thickness is more than 80 μm.
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| CN105558844A (en) * | 2015-12-18 | 2016-05-11 | 湖南尔康制药股份有限公司 | Starch capsule filled with freeze-dried meat product |
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| CN1483393A (en) * | 2002-09-17 | 2004-03-24 | 潮州市药用胶囊厂 | Starch hollow capsule and production process thereof |
| CN1687203A (en) * | 2005-04-07 | 2005-10-26 | 天津大学 | Vegetable capsule of starch composition and preparation method |
| CN103893771A (en) * | 2014-04-21 | 2014-07-02 | 湖南同泰胶囊有限公司 | Film forming composition for producing soft starch material capsule and preparation method of film forming composition |
| CN104083768A (en) * | 2014-07-02 | 2014-10-08 | 湖南尔康制药股份有限公司 | Premix auxiliary and preparation method thereof |
| CN104324381A (en) * | 2014-09-29 | 2015-02-04 | 湖南尔康制药股份有限公司 | Starch capsule having moisturizing capability and preparation method thereof |
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| US6528088B1 (en) * | 2000-06-01 | 2003-03-04 | A. E. Staley Manufacturing Co. | Highly flexible starch-based films |
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| CN1483393A (en) * | 2002-09-17 | 2004-03-24 | 潮州市药用胶囊厂 | Starch hollow capsule and production process thereof |
| CN1687203A (en) * | 2005-04-07 | 2005-10-26 | 天津大学 | Vegetable capsule of starch composition and preparation method |
| CN103893771A (en) * | 2014-04-21 | 2014-07-02 | 湖南同泰胶囊有限公司 | Film forming composition for producing soft starch material capsule and preparation method of film forming composition |
| CN104083768A (en) * | 2014-07-02 | 2014-10-08 | 湖南尔康制药股份有限公司 | Premix auxiliary and preparation method thereof |
| CN104324381A (en) * | 2014-09-29 | 2015-02-04 | 湖南尔康制药股份有限公司 | Starch capsule having moisturizing capability and preparation method thereof |
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