CN104688711A - Hollow plant capsule and preparation method thereof - Google Patents
Hollow plant capsule and preparation method thereof Download PDFInfo
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- CN104688711A CN104688711A CN201510103152.9A CN201510103152A CN104688711A CN 104688711 A CN104688711 A CN 104688711A CN 201510103152 A CN201510103152 A CN 201510103152A CN 104688711 A CN104688711 A CN 104688711A
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Abstract
The invention discloses a hollow plant capsule and a preparation method thereof. A large amount of repeated studies have found that, the hollow plant capsule is mainly composed of such raw materials as starch, optional starch derivatives and the balance of water. The hollow plant capsule further comprises other substance not larger than 2% of the weight of the raw materials of the hollow plant capsule. Parameters and control conditions of the existing process are repeatedly adjusted to prepare the hollow plant capsule, which is safe, pollution free, stable in quality, high in yield, wide in source, low in cost and wide in applicable crowd, and satisfies the standard of 2010 edition of Chinese Pharmacopoeia, and the filling percentage of the hollow plant capsule reaches the market level.
Description
Technical field
The present invention relates to one and can be widely used in food, medicine, the phyteral Capsules of health products trade and preparation thereof.
Background technology
Its shell of commercially available capsule of the current overwhelming majority is gelatin hollow capsule, and the moisture of gelatin is high, hygroscopicity is strong, poor compatibility, easily cause drug quality defective and shorten effect duration, specific religious people is had to also limit the use of gelatine capsule in addition, and along with the raising of developed countries people health care consciousness, praise highly " green health food ", particularly with Europe " bovine spongiform encephalopathy ", the fear caused with " toxic capsule " event of recent domestic report that spreads of animality infectious disease such as " foot and mouth disease " also forces masses to start to consider the succedaneum-plant hollow capsule of animality capsule.
Have a lot about the patent report of vegetalitas capsule at present, as CN1687203A, this patent points out it using starch or modified starch for primary raw material is by adding necessary plasticizer and gel manufactures capsule as glue.
CN1931145A, this patent points out that its film-forming composition is starch 5-10 part, glycerol 0-3 part, and water 0-7 part, prepares capsule through existing technique, but the colloidal sol length consuming time described in this patent.
But other material that all with the addition of in above-mentioned patent except starch, does not accomplish " green " " pure natural " truly.
Summary of the invention
The present invention is directed to current capsule Problems existing, propose a kind of completely newly without any interpolation, the Capsules of safer full starch, utilizes existing production technology, by the parameter in production control process and working condition, obtain the full starch hollow capsule of requisite quality.
For achieving the above object, concrete scheme of the present invention is:
There is provided a kind of phyteral Capsules, comprise the raw materials such as the water of starch and optional starch derivatives and surplus and make, it is characterized in that, the mass fraction of starch is 35%-55%, and the mass fraction of optional starch derivatives is the water of 0%-4% and surplus;
Wherein the mass fraction of starch is preferably 36%, and 38%, 40%, 42%, 45%, 47%, 50%, 52%.
Wherein the mass fraction of starch derivatives is preferably 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%.
Described starch is selected from frumentum, potato class, beans, the one of fruit and vegerable class or combination; Starch derivatives is selected from etherification starch, esterification starch, Oxytarch, nanometer starch crystal, the one in crosslinked starch or combination.Etherification starch can be selected from hydroxypropyl starch, hetastarch and hydroxymethyl starch; Esterification starch can be selected from phosphate ester starch, acetate starch, starch sulfate; The preferred esterification starch of starch derivatives and/or Oxytarch, the further preferred esterification starch of 2%-8% and the Oxytarch of 92%-98%.
According to demand, phyteral Capsules also can comprise gellant, plasticizer, food coloring, and the gross weight of these materials is no more than 2% of phyteral Capsules raw material gross weight.Applicant is through repeatedly testing, and when without any interpolation, the composition determining phyteral Capsules raw material of the present invention is only, the water of starch and optional starch derivatives and surplus.Phyteral Capsules is prepared by condition corresponding in production control process and parameter.
Another aspect of the present invention there is provided a kind of preparation method preparing described phyteral Capsules, comprises colloidal sol, embryo processed, cutting, screening, fit, lamp inspection, the steps such as total inspection, and the step preparing capsule most critical is colloidal sol and embryo processed, the feature of the present invention in this step of colloidal sol is, first in glue pot, add hot water adds starch and optional starch derivatives again, be incubated a period of time after intensification, bubble removing, finally filter in heat-preserving container for subsequent use; Be characterised in that in this step of embryo processed, when capsule cap dips in after offset plate dips in gum forming, offset plate will be dipped in and be pushed into top and stop the regular hour, then turnover panel for several times; Capsule body dips in after offset plate dips in gum forming, will dip in offset plate and be pushed into top and stop certain hour, and then overturn for several times, final drying.
Further, for making to obtain the homogeneous glue of quality, the hot water temperature added in colloidal sol step is at 30-40 DEG C, then add under the condition stirred after starch that mass fraction is 35-55% and mass fraction are the optional starch derivatives of 0-5% and be warming up to 50-65 DEG C, stir 10-20min at this temperature, be warming up to 75-100 DEG C with the speed of 1-2 DEG C/min again, finally stir 50-100min at this temperature.In this step of colloidal sol, aperture of filter screen makes it at 100-300 order, and mixing speed is 100-200r/min.It should be noted that under other aperture and mixing speed, also can obtain phyteral Capsules, just obtained phyteral Capsules is in outward appearance and qualitative and imperfections.
Applicant is through repeatedly testing discovery, obtain wall thickness, top thickness and the thick homogeneous phyteral Capsules of arc, most critical except colloidal sol step, embryo processed is also a very crucial step, so further, in embryo step processed, capsule cap dips in after offset plate dips in gum forming, capsule board is pushed into top and stops 0.001-8s, below top, provided with fan makes its rapid draing, then turnover panel 1-5 time; Capsule body dips in after offset plate dips in gum forming, and be pushed into top and stop 0.001-8s, below top, provided with fan makes its rapid draing, then turnover panel 1-5 time.Below top, provided with fan is to make the glue rapid shaping after dipping in glue, thus avoids moulding dose of interpolation.
In embryo step processed, baking temperature, humidity and time also have a significant impact obtained capsule quality, mainly can affect the friability of capsule, so further, temperature when controlling dry is 25-35 DEG C, humidity 35-65%, time 1-2h.By the condition in control capsule manufacture process and parameter, make the wall thickness of the capsule cap of the phyteral Capsules obtained at 85 μm-130 μm, top thickness 150 μm-220 μm, arc is thick is more than 80 μm; The wall thickness of capsule body is at 85 μm-130 μm, and top thickness 150 μm-220 μm, arc is thick is more than 80 μm.
Beneficial effect of the present invention is: can only not need with full starch to add gellant, by controlling corresponding parameter and condition prepares full starch hollow capsule on the basis of plasticizer etc., and starch source is extensive, without any side effects, cheap, larger profit can be created.
Specific embodiment
Be described below in detail embodiments of the invention, these embodiments are intended to for explaining the present invention, and can not be interpreted as limitation of the present invention.
Embodiment 1
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the cereal starch that mass fraction is 35% under the condition of 100r/min, add the water of surplus again, 10min is stirred after rising to 50 DEG C, 50min is stirred after being warming up to 100 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 300 object filter screens.Gluing after the temperature of glue in heat-preserving container is 60 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in after offset plate is pushed into top stop 1s and overturn 180 ° at 25 DEG C, dry 1h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 25 DEG C, dry 1h under the relative humidity of 40%, then through cutting, screening, fit, lamp inspection, obtains Capsules after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 2
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the potato starch that mass fraction is 55% under the condition of 150r/min, add the water of surplus again, 10min is stirred after rising to 55 DEG C, 50min is stirred after being warming up to 75 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 60 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in after offset plate is pushed into top stop 1s and overturn 180 ° at 25 DEG C, dry 1h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 25 DEG C, dry 1h under the relative humidity of 40%, then through cutting, screening, fit, lamp inspection, obtains Capsules after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 3
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the bean starch that mass fraction is 37% under the condition of 200r/min, the acetate starch of 4% adds the water of surplus again, 10min is stirred after rising to 65 DEG C, 50min is stirred after being warming up to 95 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 100 object filter screens.Gluing after the temperature of glue in heat-preserving container is 60 DEG C, capsule cap dips in after offset plate dips in gum forming, will dip in offset plate and be pushed into top and stop upset 180 ° after 1s.At 25 DEG C, dry 1h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 25 DEG C, dry 1h under the relative humidity of 40%, then through cutting, screening, fit, lamp inspection, obtains Capsules after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 4
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the cereal starch that mass fraction is 36% under the condition of 100r/min, add the water of surplus again, 10min is stirred after rising to 65 DEG C, 50min is stirred after being warming up to 85 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 60 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in after offset plate is pushed into top stop 1s and overturn 180 ° at 25 DEG C, dry 1h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 25 DEG C, dry 1h under the relative humidity of 40%, then through cutting, screening, fit, lamp inspection, obtains Capsules after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 5
Add the hot water of 35 DEG C in glue pot after, low whipping speed is add the potato starch that mass fraction is 38% under the condition of 150r/min, the hydroxypropyl starch of 0.1% and the water of surplus, 15min is stirred after rising to 50 DEG C, 75min is stirred after being warming up to 100 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 300 object filter screens.Gluing after the temperature of glue in heat-preserving container is 70 DEG C, capsule cap dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and overturn 180 ° clockwise and be pushed into rear room at 30 DEG C, dry 1.5h under the relative humidity of 50%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 30 DEG C, dry 1.5h under the relative humidity of 50%, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 6
Add the hot water of 35 DEG C in glue pot after, low whipping speed is add the potato starch that mass fraction is 38% under the condition of 150r/min, the Oxytarch of 0.5% and the water of surplus, 15min is stirred after rising to 60 DEG C, 75min is stirred after being warming up to 85 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 300 object filter screens.Gluing after the temperature of glue in heat-preserving container is 70 DEG C, capsule cap dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and overturn 180 ° clockwise and be pushed into rear room at 30 DEG C, dry 1.5h under the relative humidity of 50%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 30 DEG C, dry 1.5h under the relative humidity of 50%, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 7
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the potato starch that mass fraction is 40% under the condition of 200r/min, the starch sulfate of 1.5% and the water of surplus, 20min is stirred after rising to 65 DEG C, 74min is stirred after being warming up to 89 DEG C with the speed of 1.5 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 7
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the potato starch that mass fraction is 42% under the condition of 200r/min, the hetastarch of 2.5% and the water of surplus, 20min is stirred after rising to 65 DEG C, 85min is stirred after being warming up to 98 DEG C with the speed of 1.5 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 8
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the potato starch that mass fraction is 45% under the condition of 200r/min, the crosslinked starch of 3% and the water of surplus, 20min is stirred after rising to 65 DEG C, 96min is stirred after being warming up to 94 DEG C with the speed of 1.5 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 9
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the bean starch that mass fraction is 47% under the condition of 200r/min, the phosphate ester starch of 2% and the water of surplus, 20min is stirred after rising to 65 DEG C, 70min is stirred after being warming up to 86 DEG C with the speed of 1.5 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 10
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the cereal starch that mass fraction is 50% under the condition of 200r/min, the hydroxymethyl starch of 3% and the water of surplus, 20min is stirred after rising to 65 DEG C, 80min is stirred after being warming up to 89 DEG C with the speed of 1.5 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 11
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the fruit and vegerable kind of starch that mass fraction is 52% under the condition of 200r/min, the acetate starch of 2.0% and the water of surplus, 20min is stirred after rising to 65 DEG C, 75min is stirred after being warming up to 79 DEG C with the speed of 1.5 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Embodiment 12
Add the hot water of 35 DEG C in glue pot after, low whipping speed is add the potato starch that mass fraction is 45% under the condition of 150r/min, (in the mixture of wherein this starch derivatives, esterification starch is 5%, Oxytarch is 95%, and esterification starch can be selected from phosphate ester starch, acetate starch, starch sulfate for the esterification of 2% and Oxytarch; ) and the water of surplus, stir 15min after rising to 60 DEG C, then stir 75min after being warming up to 100 DEG C with the speed of 1 DEG C/min, decompression bubble removing, cross stand-by in heat-preserving container of 300 object filter screens.Gluing after the temperature of glue in heat-preserving container is 70 DEG C, capsule cap dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and overturn 180 ° clockwise and be pushed into rear room at 30 DEG C, dry 1.5h under the relative humidity of 50%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 30 DEG C, dry 1.5h under the relative humidity of 50%, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 1
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the starch that mass fraction is 35% under the condition of 300r/min, add the water of surplus again, 20min is stirred after rising to 65 DEG C, 100min is stirred after being warming up to 80 DEG C with the speed of 1.5 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 100 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is not all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 2
Add the hot water of 30 DEG C in glue pot after, low whipping speed is that to add mass fraction under the condition of 150r/min be the water that the starch of 37% and the acetate starch of 0.8% add surplus again, 20min is stirred after rising to 65 DEG C, 100min is stirred after being warming up to 120 DEG C with the speed of 1-2 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 400 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is not all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 3
Add the hot water of 30 DEG C in glue pot after, low whipping speed be add under the condition of 100r/min mass fraction be 55% starch add the water of surplus again, 20min is stirred after rising to 65 DEG C, 100min is stirred after being warming up to 100 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 400 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is not all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 4
Add the hot water of 30 DEG C in glue pot after, low whipping speed be add under the condition of 50r/min mass fraction be 35% starch add the water of surplus again, 20min is stirred after rising to 65 DEG C, 100min is stirred after being warming up to 100 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 400 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is not all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 5
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the starch that mass fraction is 55% under the condition of 50r/min, 0.9% nanometer starch crystal adds the water of surplus again, 20min is stirred after rising to 65 DEG C, 100min is stirred after being warming up to 100 DEG C with the speed of 1-2 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 400 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is not all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 6
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the starch that mass fraction is 41% under the condition of 50r/min, 1.3% nanometer starch crystal adds the water of surplus again, 20min is stirred after rising to 65 DEG C, 100min is stirred after being warming up to 120 DEG C with the speed of 1-2 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 400 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is not all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 7
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the starch that mass fraction is 40% under the condition of 50r/min, 1.5% nanometer starch crystal adds the water of surplus again, 20min is stirred after rising to 65 DEG C, 100min is stirred after being warming up to 120 DEG C with the speed of 1-2 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 200 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is not all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 8
Add the hot water of 30 DEG C in glue pot after, low whipping speed is add the starch that mass fraction is 40% under the condition of 50r/min, 1.5% nanometer starch crystal adds the water of surplus again, 20min is stirred after rising to 65 DEG C, 100min is stirred after being warming up to 120 DEG C with the speed of 1-2 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 400 object filter screens.Gluing after the temperature of glue in heat-preserving container is 100 DEG C, capsule cap dips in after offset plate dips in gum forming, to dip in offset plate be pushed into top to stop after 0.5s upset 180 ° clockwise at upset 180 ° of pushers counterclockwise to rear room at 25 DEG C, dry 2h under the relative humidity of 40%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 180 ° of another mistake hour hands clockwise and overturn 180 ° and overturn 180 ° clockwise again, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is not all in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 9
Add the hot water of 35 DEG C in glue pot after, low whipping speed is add the starch that mass fraction is 45% under the condition of 200r/min, (in the mixture of wherein this starch derivatives, esterification starch is 5%, Oxytarch is 95% for the esterification of 2% and Oxytarch, and esterification starch can be selected from phosphate ester starch, acetate starch, starch sulfate) and the water of surplus, 15min is stirred after rising to 60 DEG C, 75min is stirred after being warming up to 120 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 400 object filter screens.Gluing after the temperature of glue in heat-preserving container is 70 DEG C, capsule cap dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and overturn 180 ° clockwise and be pushed into rear room at 30 DEG C, dry 1.5h under the relative humidity of 50%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 30 DEG C, dry 1.5h under the relative humidity of 50%, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is distributed in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Comparative example 10
Add the hot water of 35 DEG C in glue pot after, low whipping speed is add the starch that mass fraction is 45% under the condition of 300r/min, (in the mixture of wherein this starch derivatives, esterification starch is 5%, Oxytarch is 95% for the esterification of 2% and Oxytarch, and esterification starch can be selected from phosphate ester starch, acetate starch, starch sulfate) and the water of surplus, 15min is stirred after rising to 60 DEG C, 75min is stirred after being warming up to 120 DEG C with the speed of 1 DEG C/min again, decompression bubble removing, crosses stand-by in heat-preserving container of 400 object filter screens.Gluing after the temperature of glue in heat-preserving container is 70 DEG C, capsule cap dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and overturn 180 ° clockwise and be pushed into rear room at 30 DEG C, dry 1.5h under the relative humidity of 50%, capsule body dips in after offset plate dips in gum forming, offset plate will be dipped in be pushed into top and stop after 2s first upset 360 ° of another mistake hour hands clockwise and overturn 180 °, at 30 DEG C, dry 1.5h under the relative humidity of 50%, then through cutting, screening, fit, lamp inspection, Capsules is obtained after total inspection, after tested, the indices of Capsules is distributed in 2010 editions " Chinese Pharmacopoeia " critical fields.Carry out capsule-filling experiment.
Probability test on experimental example:
Upper probability: rotate in fit process in order to detect capsule in capsule filling machine high speed, the performance of capsule.Want to reach commercially available rank, then, when capsule-filling number is more than 10000, on it, probability is at least 99.99%.
The upper probability of the various embodiments described above and comparative example the results are shown in following table:
Claims (10)
1. a phyteral Capsules, the raw material such as water primarily of starch and optional starch derivatives and surplus is made, and it is characterized in that the mass fraction of each material is: the starch of 35%-55%; The starch derivatives of 0-4%; The water of surplus.
2. a kind of phyteral Capsules according to claim 1, wherein starch is selected from frumentum, potato class, beans, the one of fruit and vegerable class or combination; Starch derivatives is selected from etherification starch, esterification starch, Oxytarch, nanometer starch crystal, the one in crosslinked starch or combination.
3. a kind of phyteral Capsules according to claim 1, raw material also comprises gellant, plasticizer, food coloring, described gellant, and the gross weight of plasticizer and food coloring is no more than 2% of raw material weight.
4. the preparation method of a kind of phyteral Capsules according to claim 1, comprises colloidal sol, embryo processed, cutting, screening, fit, lamp inspection, and the steps such as total inspection, is characterized in that:
In colloidal sol step, heating water in glue pot, then the starch adding 35%-55%; The starch derivatives of 0-4%, is incubated a period of time after intensification, bubble removing, finally filters and obtain glue in heat-preserving container;
In embryo step processed, capsule cap dips in offset plate and dips in after glue is shaped, and is pushed into top, then overturns for several times; Capsule body dips in after offset plate dips in gum forming, will dip in offset plate and be pushed into top, and then overturn for several times, final drying.
5. preparation method according to claim 4, it is characterized in that, in colloidal sol step, add the hot water of 30-40 DEG C, under agitation add starch and optional starch derivatives again, stir 10-20min after rising to 50-65 DEG C, then stir 50-100min after being warming up to 75-100 DEG C with the speed of 1-2 DEG C/min.
6. preparation method according to claim 4, is characterized in that, in colloidal sol step, aperture of filter screen is 100-300 order.
7. preparation method according to claim 4, is characterized in that, in colloidal sol step, mixing speed is 100-200r/min.
8. preparation method according to claim 4, is characterized in that, in embryo step processed, capsule cap dips in after offset plate dips in gum forming, and after being pushed into top, then stop 0.001-8s, below top, provided with fan makes its rapid draing, then turnover panel 1-5 time; Capsule body dips in after offset plate dips in gum forming, and after being pushed into top, then stop 0.001-8s, below top, provided with fan makes its rapid draing, then turnover panel 1-5 time.
9. preparation method according to claim 4, is characterized in that, in embryo step processed, drying condition is temperature 25-35 DEG C, humidity 35-65%, time 1-2h.
10. preparation method according to claim 4, is characterized in that, after embryo processed, the blank of gained controls the wall thickness of its capsule cap at 85 μm-130 μm, top thickness 150 μm-220 μm, and arc is thick is more than 80 μm; The wall thickness of capsule body is at 85 μm-130 μm, and top thickness 150 μm-220 μm, arc is thick is more than 80 μm.
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