CN1483393A - Starch hollow capsule and production technslogy thereof - Google Patents

Starch hollow capsule and production technslogy thereof Download PDF

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Publication number
CN1483393A
CN1483393A CNA021347506A CN02134750A CN1483393A CN 1483393 A CN1483393 A CN 1483393A CN A021347506 A CNA021347506 A CN A021347506A CN 02134750 A CN02134750 A CN 02134750A CN 1483393 A CN1483393 A CN 1483393A
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CN
China
Prior art keywords
starch
assisted
plasticizer
glue
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA021347506A
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Chinese (zh)
Inventor
李加海
李泳雪
王春龙
许锐鹏
张雪原
李煜龙
李桂龙
许雄群
陈坤昭
林洽强
黄旭潘
许舜金
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chaozhou Research Center For Drug Delivery
CHAOZHOU CITY MEDICAL CAPSULE FACTORY
Original Assignee
Chaozhou Research Center For Drug Delivery
CHAOZHOU CITY MEDICAL CAPSULE FACTORY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chaozhou Research Center For Drug Delivery, CHAOZHOU CITY MEDICAL CAPSULE FACTORY filed Critical Chaozhou Research Center For Drug Delivery
Priority to CNA021347506A priority Critical patent/CN1483393A/en
Publication of CN1483393A publication Critical patent/CN1483393A/en
Pending legal-status Critical Current

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Abstract

The present invention relates to a starch hollow capsule and its production process. It is mainly characterized by that said capsule is composed of (wt%) 25%-94.9% of plant starch or starch derivative, 0.1%-30% of plasticizer and 5%-20% of water through the processes of mixing starch or starch derivative and water, heating them to above 60 deg.C, stirring them uniformly, adding plasticizer, uniformly mixing them, heat-insulating, standing still, removing bubble and pouring the above-mentioned material into mold, drying so as to obtain the invented hollow capsule.

Description

The hollow glue of a kind of starch is assisted and production technology
Technical field
The present invention relates to a kind of medicinal hollow glue and assist and production technology, the hollow glue that does not especially contain animal proteinum is assisted, and comprises that ebonite is assisted with flexible glue to assist and production technology.
Background technology
At present, hollow glue is assisted and is comprised that it is gelatin that ebonite is assisted the main component of assisting with flexible glue, its production technology mainly is to utilize the skin from animal, the gelatin that bone extracts, and adds some plasticizers, edible pigment and opacifier and make gelatin solution, and the reuse mould is stained with glue, solidify, dry and form.This glue by manufacturing of gelatin assist behind the filling medicine owing to gelatin contain animal proteinum be subject to environmental change and in the composition influence of powder charge thing, defective such as existence easily becomes fragile, degeneration, disintegration exceed standard.In view of this, it is that primary raw material is made plant gum and assisted that people attempt again with water-soluble cellulose, overcome effectively because the hidden danger that animal proteinum exists, but its poor mobile performance, disintegration instability, and cost height is difficult to adapt to mechanization filling medicine.In sum, existing glue,medicinal is assisted owing to be subjected to raw-material the influence and the restriction of traditional handicraft, and its character remains the instability objectively, affects the shelf-life that it is deposited widely.
Summary of the invention
The objective of the invention is to disclose the hollow glue of a kind of starch and assist, this glue is assisted and is had stable in properties, thereby can prolong the shelf-life that stores, energy savings.
Another object of the present invention is to disclose the production technology that the hollow glue of above-mentioned starch is assisted, thereby reaches environment-friendly high-efficiency, and simple and direct easy control is convenient and practical.
Above-mentioned purpose of the present invention is to realize by such technical scheme, be that the hollow glue of starch of the present invention is assisted by components such as plant amylum or starch derivatives, plasticizer, water and formed, the percentage by weight of described plant amylum or starch derivatives, plasticizer, water is plant amylum or starch derivatives 25%-94.9%, plasticizer 0.1%-30%, water 5%-20%.
Moreover, as the production technology that the present invention taked, comprise the production technology that empty hard is assisted and flexible glue is assisted, wherein ebonite is assisted and is comprised that system liquid, mucus, oven dry, cutting, fit, flexible glue are assisted and comprise system liquid, be stained with liquid, cooling, suction mould, material filling, pressing, oven dry; The system liquid that described ebonite is assisted and flexible glue is assisted all is that starch or starch derivatives, water is mixed and be heated to more than 60 ℃ after by proportioning, evenly stirs, and then adds plasticizer by proportioning, and mix homogeneously, insulation is left standstill, and removes to pour the insulation hopper into behind the bubble and wait to be stained with.
The system liquid that described ebonite is assisted and flexible glue is assisted all is to be by mixed after 10.2-61.8% and the 35.3-88.2% proportioning and be heated to 65 ℃ with starch or starch derivatives, water, evenly stir, and then the proportioning of pressing 0.1-25.3% adds plasticizer, mix homogeneously, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
The system liquid that described ebonite is assisted and flexible glue is assisted all is to be by mixed after 41.2% and 52.2% proportioning and be heated to 65 ℃ with starch or starch derivatives, water, evenly stir, and then add plasticizer, mix homogeneously by 6.6% proportioning, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
Described plasticizer is a glycerol.
Adopt technique scheme, do not contain thereby amylan disclosed in this invention is assisted animal proteinum make its not changeableness, become fragile, disintegration is stable, prolongs greatly to store the shelf-life and reduce cost.Moreover the environmental pollution that can avoid the extraction because of animal proteinum to cause, be beneficial to the simple and direct easy control of environmental protection and technology.
The specific embodiment
Below in conjunction with embodiment the present invention is made further enumeration.
With 100g is example, takes by weighing starch or starch derivatives 10.2-61.8g,, be preferably 41.2g; Add entry 35.3-88.2g then, preferably 52.2g; And be heated to 65 ℃, evenly be stirred to and fully dissolve the back and add plasticizer glycerol 0.1-25.3g, be preferably 6.6g, mix homogeneously, insulation is left standstill, pour in the insulation hopper after removing bubble, again through be stained with liquid, dry, pull out shell, cutting, fit and make ebonite and assist.Or again through being stained with liquid, cooling, suction mould, material filling, pressing, oven dry and make flexible glue and assist.

Claims (6)

1, the hollow glue of a kind of starch is assisted, it is characterized in that the hollow glue of described starch is assisted by components such as plant amylum or starch derivatives, plasticizer, water is formed, and the percentage by weight of described plant amylum or starch derivatives, plasticizer, water is plant amylum or starch derivatives 25%-94.9%, plasticizer 0.1%-30%, water 5%-20%.
2, the hollow glue of a kind of starch according to claim 1 is assisted, and it is characterized in that described plasticizer is a glycerol.
3, the hollow glue of a kind of starch production technology of assisting comprises the production technology that empty hard is assisted and flexible glue is assisted, and wherein ebonite is assisted and comprised that system liquid, mucus, oven dry, cutting, fit, flexible glue are assisted and comprise system liquid, be stained with liquid, cooling, suction mould, material filling, pressing, oven dry; It is characterized in that described ebonite is assisted and flexible glue is assisted system liquid all is that starch or starch derivatives, water is mixed and be heated to more than 60 ℃ after by proportioning, evenly stir, and then add plasticizer, mix homogeneously by proportioning, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
4, the hollow glue of a kind of starch according to claim 2 production technology of assisting, it is characterized in that described ebonite is assisted and flexible glue is assisted system liquid all is is by mixed after 10.2-61.8% and the 35.3-88.2% proportioning and be heated to 65 ℃ with starch or starch derivatives, water, evenly stir, and then the proportioning of pressing 0.1-25.3% adds plasticizer, mix homogeneously, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
5, the hollow glue of a kind of starch according to claim 3 production technology of assisting, it is characterized in that described ebonite is assisted and flexible glue is assisted system liquid all is is by mixed after 41.2% and 52.2% proportioning and be heated to 65 ℃ with starch or starch derivatives, water, evenly stir, and then add plasticizer by 6.6% proportioning, mix homogeneously, insulation is left standstill, and removes to pour the insulation hopper behind the bubble into and wait to be stained with.
6, the production technology of assisting according to the hollow glue of any starch described in the claim 3-5 is characterised in that described plasticizer is a glycerol.
CNA021347506A 2002-09-17 2002-09-17 Starch hollow capsule and production technslogy thereof Pending CN1483393A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNA021347506A CN1483393A (en) 2002-09-17 2002-09-17 Starch hollow capsule and production technslogy thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA021347506A CN1483393A (en) 2002-09-17 2002-09-17 Starch hollow capsule and production technslogy thereof

Publications (1)

Publication Number Publication Date
CN1483393A true CN1483393A (en) 2004-03-24

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Family Applications (1)

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Country Status (1)

Country Link
CN (1) CN1483393A (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1333006C (en) * 2005-04-07 2007-08-22 天津大学 Vegetable capsule of starch composition and preparation method
CN100393296C (en) * 2004-12-09 2008-06-11 浙江工业大学 Formula of making hollow capsule and its preparation method
WO2010020098A1 (en) * 2008-08-18 2010-02-25 北京天衡药物研究院 Gastric retention drug delivery system, preparation method and use thereof
CN101817938A (en) * 2010-03-18 2010-09-01 上海心尔新材料科技股份有限公司 Transparent starch-packaging material and production method thereof
CN101708174B (en) * 2009-12-11 2011-04-13 梁贤昌 Plant hollow capsule, soft capsule composition and preparation methods thereof
CN101693020B (en) * 2009-10-22 2011-04-20 华慧颖 Enteric soluble medicine empty capsule prepared by replacing part of gelatin with defatted soybean meal extractive and preparation process
CN102525995A (en) * 2011-12-23 2012-07-04 湖北人福康华药用辅料有限公司 Plant officinal hollow capsule and preparation method thereof
CN104324381A (en) * 2014-09-29 2015-02-04 湖南尔康制药股份有限公司 Starch capsule having moisturizing capability and preparation method thereof
EP2865374A1 (en) 2013-10-26 2015-04-29 Zhongshan Capsule Starch Material Technology Co., Ltd. Mixing and extruding method for preparing starch softgel capsules
CN104688711A (en) * 2015-03-09 2015-06-10 湖南尔康制药股份有限公司 Hollow plant capsule and preparation method thereof
EP2937081A1 (en) 2014-04-21 2015-10-28 Hunan Er-Kang Pharmaceutical Co., Ltd. Hydroxypropyl starch vacant capsules and a process for producing them
CN105475942A (en) * 2015-12-18 2016-04-13 湖南尔康制药股份有限公司 Freeze-dried bee product capsule
CN105709234A (en) * 2016-01-29 2016-06-29 中国药科大学 Oxidized hydroxypropyl starch empty capsules and preparation process thereof
CN104666275B (en) * 2015-03-09 2017-04-26 湖南尔康制药股份有限公司 Starch-based plant empty capsule

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100393296C (en) * 2004-12-09 2008-06-11 浙江工业大学 Formula of making hollow capsule and its preparation method
CN1333006C (en) * 2005-04-07 2007-08-22 天津大学 Vegetable capsule of starch composition and preparation method
WO2010020098A1 (en) * 2008-08-18 2010-02-25 北京天衡药物研究院 Gastric retention drug delivery system, preparation method and use thereof
CN101693020B (en) * 2009-10-22 2011-04-20 华慧颖 Enteric soluble medicine empty capsule prepared by replacing part of gelatin with defatted soybean meal extractive and preparation process
CN101708174B (en) * 2009-12-11 2011-04-13 梁贤昌 Plant hollow capsule, soft capsule composition and preparation methods thereof
CN101817938B (en) * 2010-03-18 2013-01-09 上海心尔新材料科技股份有限公司 Transparent starch-packaging material and production method thereof
CN101817938A (en) * 2010-03-18 2010-09-01 上海心尔新材料科技股份有限公司 Transparent starch-packaging material and production method thereof
CN102525995B (en) * 2011-12-23 2013-10-30 湖北人福康华药用辅料有限公司 Plant officinal hollow capsule and preparation method thereof
CN102525995A (en) * 2011-12-23 2012-07-04 湖北人福康华药用辅料有限公司 Plant officinal hollow capsule and preparation method thereof
EP2865374A1 (en) 2013-10-26 2015-04-29 Zhongshan Capsule Starch Material Technology Co., Ltd. Mixing and extruding method for preparing starch softgel capsules
EP2937081A1 (en) 2014-04-21 2015-10-28 Hunan Er-Kang Pharmaceutical Co., Ltd. Hydroxypropyl starch vacant capsules and a process for producing them
US9693964B2 (en) 2014-04-21 2017-07-04 Hunan Er-Kang Pharmaceutical Co., Ltd. Hydroxypropyl starch vacant capsules and a process for producing them
CN104324381A (en) * 2014-09-29 2015-02-04 湖南尔康制药股份有限公司 Starch capsule having moisturizing capability and preparation method thereof
CN104324381B (en) * 2014-09-29 2017-01-18 湖南尔康制药股份有限公司 Starch capsule having moisturizing capability and preparation method thereof
CN104688711A (en) * 2015-03-09 2015-06-10 湖南尔康制药股份有限公司 Hollow plant capsule and preparation method thereof
CN104666275B (en) * 2015-03-09 2017-04-26 湖南尔康制药股份有限公司 Starch-based plant empty capsule
CN104688711B (en) * 2015-03-09 2017-08-29 湖南尔康制药股份有限公司 A kind of phyteral Capsules and preparation method thereof
CN105475942A (en) * 2015-12-18 2016-04-13 湖南尔康制药股份有限公司 Freeze-dried bee product capsule
CN105709234A (en) * 2016-01-29 2016-06-29 中国药科大学 Oxidized hydroxypropyl starch empty capsules and preparation process thereof

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