CN104666783A - Traditional Chinese medicine preparation for treating simple obesity and preparation method - Google Patents
Traditional Chinese medicine preparation for treating simple obesity and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating simple obesity as well as a preparation method. The traditional Chinese medicine preparation comprises the following raw medical materials: ancients euphorbia stems, leaves of Chinese desmos, coprinus atramentarius, lepidogrammitis intermedia, radix glycyrrhizae preparata, morchella crassipes, fruits of fiverleaf akebia, potentilla fruticosa, tofieldia divergens, sensitive plant roots, folium eucalypti, drosera burmanni vahl, flowers of Japanese banana, calystegia soldanella, Chinese gall leaven, sieve sedge, gerbera delauayi franch and calabash gourd. The traditional Chinese medicine preparation has the benefits that the traditional Chinese preparation is completely prepared from pure natural traditional Chinese medicine components, has no harm to the human body, does not have side effects or toxicity and does not require excessively dieting, and all that is required is to avoid excessive eating; the curative effect is good, extra fat and water dampness left in the human body due to metabolism can be converted and eliminated, the healthy qi and physiological functions of the human body are not harmed, metabolism of the human body is promoted, physical fitness is realized, rubbish in the human body and hidden disease risks are eliminated, and the weight cannot rebound after reduced.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation and preparation method for the treatment of simple obesity.
Background technology
The traditional Chinese medical science is just on the books as far back as Huangdi's Internal Classics, and people has fertilizer, has cream, there is meat, point out fat feature: figure is fat, greasiness, blood glues silk fabric, run slowly this be the disease of Sorghum vulgare Pers. also, people's many surfeit delicious food savoury of obesity, hinders taste, make dysfunction of the spleen in transportation, essence of water and grain can not change promoting generation of vital essence and blood, form cream fat expectorant turbid in store, store and form obesity in skin; Taste excess-heat rapid digestion of food is apt to flesh, polyphagia polydipsia and cause QI and blood and have a surplus, change cream fat and in store and also can cause fat; Liver controlling conveyance and dispersion, if long-term feelings will not the depressed expectorant of Shu Ze coagulate, or catharsis imbalance and cause dysfunction of the spleen in transportation, raw in phlegm-damp; The main water of kidney, deficiency of kidney-QI then can not promote the circulation of qi and water, and causes in turbid damp and stop, and overflow in skin, and it is fat to cause fat; Worn with age, vital organs of the human body hypofunction, essence of water and grain also can not can cause and stop in turbid damp and cause fat fat by normal defeated cloth.
Modern medicine study shows, obesity has become in society the root causing various disease, and data show according to statistics, and in obese people, the obese patient of 90% suffers from the three-hypers diseases such as hypertension, hyperlipidemia, hyperglycemia; The obese patient of 70% suffers from coronary heart disease, cardiovascular disease, has the patient of 50% to have the diseases such as gout, cholelithiasis, cholecystitis simultaneously; The obese patient of 78% can change into diabetes, insulin deficiency, wherein has again the patient of 90% to there will be the diseases such as acute and chronic pancreatitis; The obese patient of 90% suffers from cerebral arteriosclerosis, cerebral thrombosis, the real tune of brain kinetic energy microcirculation, and wherein majority there will be the diseases such as apoplexy, hemiplegia and numb limbs and tense tendons; Senile obese patient also there will be the diseases such as dementia, insomnia, forgetful and osteoporosis.The annual obese patient of current China just increases with the ratio of 5%, and occurred to infant, children and adolescents etc. become younger development trend, China is every year because treating the various diseases caused by obesity, account for 2 ~ 3% of GDP, as can be seen here, prevention and therapy obesity also becomes the major issue being related to population health and national sustainable development.
Obesity causes the too much accumulation of body fat because the absorption of energy exceedes the consumption of energy, and make body fat overheap, body weight increases.Definite obesity definition refers to body fat abnormal increase, but not the exceeding standard of body weight.According to the cause of disease, obesity can be divided into pure and Secondary cases two class.Simple Obesity refers to only have obesity and without the obesity of any organic disease.Simple Obesity can be divided into again the acquired obesity of the constitutional obesity of onset childhood and adult onset.Simple Obesity may change with the appetite stimulator of inherited genetic factors, central nervous system, endocrine function, metabolic factor and sit quietly, the living habit of polyphagia etc. is relevant.Secondary Obesity is secondary to the cause of disease of the Simple Obesity such as some disease is as early stage in the inflammation of hypothalamus one hypophysis, tumor, wound, hypercortisolism, hypothyroidism, hypogonadism, patients with type Ⅰ DM, insulinoma more and pathogenesis still imperfectly understands, may be relevant with following factors.Inherited genetic factors, epidemiology shows some overweight people family's morbidity tendency.Neuropsychical facto, zoopery and clinical observation show the ingested regulating action of nervous and mental factors to people.Endocrine factors, many hormones such as thyroxine, insulin, glucocorticoid etc. may take part in the pathogenesis of obesity.Life style and dietary habit, do not like that movable people's consumed energy reduces, easily obesity occur.Athlete is after stop motion, often take the photograph people's height calorie diet or heavy, smoker after smoking cessation, Food intake before bed custom, like eating greasy food, every day the few and food-intake of often eating of number of times of having meal large etc. all relevant with the generation of Simple Obesity, but be not unique cause of disease.
The most of slimming medicine of domestic and international slimming medicine present situation such as appetite suppressant, diuretic, cathartic etc. have the side effect of varying degree.Slimming medicine salable mainly contains in the world at present: the sibutramine in Germany (Ke Nuo) KNOLL pharmaceutical factory; The orlistat of Roche Holding Ag of Switzerland.The proposition of this concept of losing weight is only thing about ten years in China, and diet products are through having walked the renewal course of develop rapidly.The mid-90 in 20th century, weight-reducing product market experienced by twice product renewal so far.The first generation is rushed down clearly type diet products and is mostly improved by traditional diet tea, utilizes Folium Camelliae sinensis esterified greasy effect of dispelling to lose weight.In order to embody the effect of quick weight-lossing, some producers add in diet tea dosage not wait cathartic as Chinese herbal medicine such as Radix Et Rhizoma Rhei, Natrii Sulfas and sennaes, by the moisture in the mode human body of diarrhoea and protein, what cause is the illusion lost weight, and but fails to touch the basic of obesity.These diet teas of long-term taking, also can cause damage to function of human body, occur the symptoms such as habitual diarrhea, gastrointestinal dysfunction and human body dehydration.The hungry substituted type diet products of the second filial generation reach fat-reducing object by " going on a diet ", namely replace normal diet with low-calorie diet, to reduce the absorption of human body to fat, saccharide, rely on the consumption of human body own fat to carry out makeup energy.In order to cause the sensation of " having had enough ", in some substituted type diet food, also add the medicine (inactive in the U.S. at present) such as appetite suppressant fenfluramine, An Feila ketone.Life-time service can make health be in starvation, not only reduces the mobility of body each side, once cut out, body weight just can quick rebound.Third generation health type diet products with World Health Organization (WHO) propose do not suffer from diarrhoea, do not go on a diet and not weak for fat-reducing principle, effect increases than the first generation, second filial generation diet products.
Commercially the medicine of prevention and therapy obesity, health product are multifarious, of a great variety, principle of its fat-reducing is absorbed as means with appetite-suppressing and oil-control, wherein science and by the generally accepted mode of patient be exactly adjustment the mankind dietary structure, improve food quality, reduce human body to the intake of oils and fats, meat, eggs and carbohydrate food, shortcoming is the reduction of the mankind's enjoying to the full ambrosia.And there is the side reaction affecting the functions such as liver, kidney, heart sometimes in these medicines by oral fat-reducing, health product.Medical research simultaneously shows, oils and fats in body fat, mainly contain two class chemical substance compositions, one class is that satisfied fatty acid fat accounts for 79% of fatty oils and fats, belong to not easily oxidized, decompose, the material of metabolism, be easy to be gathered in subcutaneous fat, sometimes during this kind of material intravasation circulation, also easily form thrombosis condensation product, occlude blood mobility, increase the stickiness of blood, reduce blood flow, thus brain keeping deficiency can be produced, cause vasospasm and contraction, cause coronary heart disease, cardiovascular disease, cerebral arteriosclerosis, apoplexy, hemiplegia and dementia wait disease.This is also main harmful material that obese patient falls ill.Another kind of is that unsaturated fatty acid accounts for 20% of total fatty oils and fats, it is the material that a class is absorbed by the body, transforms, also be the energy component of each organ metabolic demand of human body, this constituents also has effect of thrombosis, arrhythmia, anti-cerebral arteriosclerosis in antiinflammatory, anti-blood in human body simultaneously, is the material useful to human body.Modern medicine study confirms, unsaturated fatty acid prevents the effect of the diseases such as coronary heart disease, cardiovascular disease, diabetes, cancer, hepatitis, cerebral arteriosclerosis, apoplexy, hemiplegia, dull-witted depression, psychotic disorder, rheumatoid and rheumatic arthritis, neurodermatitis, emphysema, asthma, nephritis in addition, and the important composition material of this kind of material or human brain liposome.How neither to affect human body healthy, effectively controlling again fat, to reach attractive in appearance and healthy object be need the technical barrier of solution badly.
Summary of the invention
Technical problem to be solved by this invention is, overcome existing diet products side effect large, unsuitable life-time service and the defect of easily bounce-back, utilize the theory of Chinese medical science that China is traditional, Chinese medicine preparation of a kind of novel treatment simple obesity and preparation method thereof is provided, selects natural Chinese medicines composition completely, human body is free from side effects, avirulence, good effect and weight reducing after not easily rebound.
Ask to solve above-mentioned technology, the invention provides a kind of Chinese medicine preparation for the treatment of simple obesity, described Chinese medicine preparation comprises following raw medicinal material: Caulis Euphorbiae Antiquori, Folium desmoris, ink-cap (Coprinus atramentartius), middle dominoes Herba pteridii latiusculi, Radix Glycyrrhizae Preparata, big legs Gaster caprae seu Ovis dish, Fructus Akebiae, Dasiphora fruticosa (L.) Rydb., flat bamboo is surveyed, Radix Mimosae Pudicae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Habenaria aitchisonii, Flos Musae, shore Flos Calystegiae sepii, Mass Galla chinesis et camelliae Fermentata, Shi Shi, Bai Ye do not turn over and Pericarpium Lagenariae sicerariae.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Caulis Euphorbiae Antiquori 5 ~ 10 weight portion, Folium desmoris 8 ~ 15 weight portion, ink-cap (Coprinus atramentartius) 10 ~ 30 weight portion, middle dominoes Herba pteridii latiusculi 20 ~ 30 weight portion, Radix Glycyrrhizae Preparata 20 ~ 35 weight portion, big legs Gaster caprae seu Ovis dish 15 ~ 25 weight portion, Fructus Akebiae 25 ~ 35 weight portion, Dasiphora fruticosa (L.) Rydb. 10 ~ 20 weight portion, flat bamboo surveys 25 ~ 40 weight portions, Radix Mimosae Pudicae 10 ~ 20 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15 ~ 30 weight portion, Habenaria aitchisonii 20 ~ 30 weight portion, Flos Musae 15 ~ 25 weight portion, shore Flos Calystegiae sepii 20 ~ 30 weight portion, Mass Galla chinesis et camelliae Fermentata 25 ~ 35 weight portion, real 20 ~ 30 weight portions of teacher, Bai Ye does not turn over 15 ~ 25 weight portions and Pericarpium Lagenariae sicerariae 25 ~ 35 weight portion.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be preferably: Caulis Euphorbiae Antiquori 5 ~ 8 weight portion, Folium desmoris 10 ~ 15 weight portion, ink-cap (Coprinus atramentartius) 20 ~ 25 weight portion, middle dominoes Herba pteridii latiusculi 20 ~ 25 weight portion, Radix Glycyrrhizae Preparata 20 ~ 30 weight portion, big legs Gaster caprae seu Ovis dish 15 ~ 20 weight portion, Fructus Akebiae 30 ~ 35 weight portion, Dasiphora fruticosa (L.) Rydb. 15 ~ 20 weight portion, flat bamboo surveys 30 ~ 40 weight portions, Radix Mimosae Pudicae 10 ~ 15 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20 ~ 25 weight portion, Habenaria aitchisonii 25 ~ 30 weight portion, Flos Musae 20 ~ 25 weight portion, shore Flos Calystegiae sepii 25 ~ 30 weight portion, Mass Galla chinesis et camelliae Fermentata 30 ~ 35 weight portion, real 25 ~ 30 weight portions of teacher, Bai Ye does not turn over 20 ~ 25 weight portions and Pericarpium Lagenariae sicerariae 30 ~ 35 weight portion.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably again: Caulis Euphorbiae Antiquori 6 weight portion, Folium desmoris 10 weight portion, ink-cap (Coprinus atramentartius) 25 weight portion, middle dominoes Herba pteridii latiusculi 22 weight portion, Radix Glycyrrhizae Preparata 30 weight portion, big legs Gaster caprae seu Ovis dish 20 weight portion, Fructus Akebiae 35 weight portion, Dasiphora fruticosa (L.) Rydb. 18 weight portion, flat bamboo surveys 35 weight portions, Radix Mimosae Pudicae 12 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 22 weight portion, Habenaria aitchisonii 28 weight portion, Flos Musae 20 weight portion, shore Flos Calystegiae sepii 28 weight portion, Mass Galla chinesis et camelliae Fermentata 33 weight portion, real 28 weight portions of teacher, Bai Ye does not turn over 22 weight portions and Pericarpium Lagenariae sicerariae 35 weight portion.
When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 85% ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 ~ 5 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 4 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.24 ~ 0.46:0.2 ~ 0.38, incapsulate in housing by described capsule 's content, obtain capsule finished product.
When the dosage form of described Chinese medicine preparation is oral liquid, its preparation method comprises the following steps:
The first step, by Caulis Euphorbiae Antiquori, Folium desmoris, ink-cap (Coprinus atramentartius), middle dominoes Herba pteridii latiusculi, Radix Glycyrrhizae Preparata, big legs Gaster caprae seu Ovis dish, Fructus Akebiae and Dasiphora fruticosa (L.) Rydb. mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 ~ 6 times of water gagings, soaks 5 ~ 10 hours, then boil 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28 ~ 1.30;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 25 ~ 35 hours, and refrigerated storage temperature is 2 ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
Beneficial effect of the present invention: Chinese medicine preparation provided by the invention, select natural Chinese medicines composition completely, do not contain any toxicity and zest or appetite-suppressing and affect human normal and run, absorb, the material of growth, the normal operation not affecting human endocrine and the dirty function of internal organs absorbs, harmless, be free from side effects, avirulence, do not need too to go on a diet, as long as suitably note too not taking food, good effect, can transform and eliminate superabundant fats and the water because of metabolism in retention body and wet, do not hinder human righteousness and physiological function, for human body is weeded out the old and bring forth the new, enhance metabolism, make symmetry and eliminate the rubbish in body, the hidden danger that eliminates a disease and weight reducing after not easily rebound.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of simple obesity, it comprises: Caulis Euphorbiae Antiquori, Folium desmoris, ink-cap (Coprinus atramentartius), middle dominoes Herba pteridii latiusculi, Radix Glycyrrhizae Preparata, big legs Gaster caprae seu Ovis dish, Fructus Akebiae, Dasiphora fruticosa (L.) Rydb., the survey of flat bamboo, Radix Mimosae Pudicae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Habenaria aitchisonii, Flos Musae, shore Flos Calystegiae sepii, Mass Galla chinesis et camelliae Fermentata, Shi Shi, Bai Ye do not turn over and Pericarpium Lagenariae sicerariae.
Wherein, the pharmacological property of various raw medicinal material is as follows:
Caulis Euphorbiae Antiquori: call pure sun grass, A Lishu, sheep are not wiped, Os Draconis thorn, poplar bifurcation, fiery rainbow, Huo Xiang, U.S. pool are cut greatly, Buddha's warrior attendant tree, sword in thousand, flame, smelly pine, Tai Geci, the little Green Dragon, camwood are logical, hundred step recuperating depleted YANG, round Buddha's warrior attendant, Os Draconis are set, sheep does not suffer, Euphorbia royleana Boiss..For the stem of euphorbia plant Caulis Euphorbiae Neriifoliae.Bitter; Cold; Poisonous.GUIXIN; Large intestine channel.Diuresis relieving constipation; To draw out pus by applying a plaster to the affected part removing the necrotic tissue; Killing parasites for relieving itching.Main edema; Tympanites; Have loose bowels; Dysentery; Food stagnation; Mass in the abdomen; Furuncle; Carbuncle; Scabies.(taking passages " China's book on Chinese herbal medicine ")
Folium desmoris: another name leaf of Radix Glycosmidis Citrifoliae, beading Folium desmoris, false Folium desmoris are the leaf of annonaceae plant Desmos chinensis.Toil; Temperature; Slightly poisonous.Return spleen; Liver Channel.Expelling wind and removing dampness, blood-activating analgetic, invigorating the spleen and regulating the stomach, preventing the attack (or recurrence) of malaria parasite killing.Main rheumatic ostalgia; Malaria; Edema; Traumatic injury; Rubella; Scabies; Rotten foot.(taking passages " China's book on Chinese herbal medicine ")
Ink-cap (Coprinus atramentartius): another name Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), terrible umbrella, haunted house, terrible bacterium, Di Gai, Siberian cocklebur, a night fine and soft.Mycophyta Basidiomycetes Agaricales Agaricaceae ink-cap (Coprinus atramentartius) Coprinus atramentarius (Bull.) Fr., is used as medicine with sporophore.Sweet, cold.Benefit the intestines and stomach, phlegm-eliminiating and qi-regulating, removing toxic substances, detumescence.Often eating can be aid digestion, eliminates the phlegm, and controls innominate toxic swelling and other carbuncle sore.(taking passages " national Chinese herbal medicine compilation ")
Middle dominoes Herba pteridii latiusculi: another name stone melon rice, Schlumbergera bridgesii's shell, Parathelypteris glanduligera (Kunze) Ching.For the herb of dominoes Herba pteridii latiusculi in the middle of Plants of Polypodiaceae.Sweet; Bitter; Flat.Return spleen channel.Invigorating the spleen and benefiting QI.Main insufficiency of the spleen food stagnation; Dyspepsia; Infantile malnutrition.(taking passages " China's book on Chinese herbal medicine ")
Radix Glycyrrhizae Preparata: the Preparation process product of Radix Glycyrrhizae.Sweet, flat.GUIXIN, lung, spleen, stomach warp.Spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.(taking passages " national Chinese herbal medicine compilation ")
Big legs Gaster caprae seu Ovis dish: another name wrinkle handle Morchella esculenta (L.) Pers, big legs Morchella esculenta (L.) Pers, Gaster caprae seu Ovis dish.Mycophyta Ascomycetes Pezizale saddle Cordycepps big legs Gaster caprae seu Ovis dish Morchella crassipes (Vent.) Pers., is used as medicine with sporophore.Sweet, flat.Benefit the intestines and stomach, phlegm-eliminiating and qi-regulating.For dyspepsia, abundant expectoration is breathed hard.(taking passages " national Chinese herbal medicine compilation ")
Fructus Akebiae: be the mature fruit of plants of Lardizabalaceae Caulis Akebiae Akebia quinata (Thunb.) Decne, threeleaf akebia A.trifoliata (Thunb.) Koidz.var.australis (Dies) .Rehd..Mildly bitter flavor, property is put down.Return liver, stomach, urinary bladder channel.Dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.(taking passages " China's book on Chinese herbal medicine ")
Dasiphora fruticosa (L.) Rydb.: another name arteries and veins leaf Folium seu Semen Daphniphylli oldhami, Daphniphyllum paxianum Rosanth.For the flower of rosaceous plant bush cinqefoil Potentilla fruticosaL..Bitter; Cool.Return spleen; Stomach; Liver Channel.Removing dampness spleen invigorating.Main dampness taste; Inappetence; Body and face edema; Leucorrhea with red and white discharge, mastitis." Inner Mongol Chinese herbal medicine ": invigorating the spleen for eliminating dampness.Control dyspepsia, mastitis.(taking passages " China's book on Chinese herbal medicine ")
Flat bamboo is surveyed: be the herb of liliaceous plant crutch Rhizoma Bergeniae purpurascentis.Sweet; Light; Flat.Invigorating spleen to remove dampness stomach function regulating; Promoting blood circulation and detumescence.Main wet Sheng is insufficiency of the spleen; Diarrhoea; Edema; Dysuria; Food stagnation is had a stomachache; Dizziness and tinnitus; Menoxenia; Traumatic injury; Rubella; Infantile pneumonia.(taking passages " China's book on Chinese herbal medicine ")
Radix Mimosae Pudicae: be the root of leguminous plant Herba Mimosae Pudicae Mimosa pudica L..Puckery; Micro-hardship; Warm in nature.Relieving cough and resolving phlegm; Dampness removing dredging collateral; Stomach function regulating removing food stagnancy; Improving eyesight is calm.Main chronic bronchitis; Rheumatalgia; Chronic gastritis; Infantile dyspepsia; Amenorrhea; Headache and insomnia; Dim eyesight.(taking passages " China's book on Chinese herbal medicine ")
Folium eucalypti globueli (Eucalyptus globulus Labill.): another name eucalyptus leaves, Eucalyptus globulus Labill leaf, sheep amomum tsaoko leaf.For the leaf of myrtle Eucalyptus globulus Labill.Acrid in the mouth; Bitter; Cold in nature.Return lung; Stomach; Spleen; Liver Channel.Dispelling wind to relieve the exterior syndrome; Heat-clearing and toxic substances removing; Phlegm-eliminiating and qi-regulating; Killing parasites for relieving itching.Main flu; High dyspnea of heat type is coughed; Pertussis; Abdominal distention; Diarrhoea; Dysentery; Hook; Filaricide; Malaria; Rheumatalgia; Eczema; Scabies; Burn and scald; Traumatic hemorrhage.(taking passages " China's book on Chinese herbal medicine ")
Habenaria aitchisonii: another name silk thread string copper coin, Flos Hibisci Mutabilis, a Herba droserae burmannii.Droseraceae drosera Habenaria aitchisonii Drosera burmanni Vahl, with all herbal medicine.Sweet, micro-hardship, cool.Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, transforming phlegm and dispersing accumulations.For enteritis, dysentery, laryngopharynx swelling and pain, cough due to lung-heat, spitting of blood, epistaxis, infantile malnutrition.(taking passages " national Chinese herbal medicine compilation ")
Flos Musae: be the flower of Musaceae plant Musa basjoo Sieb. Et Zucc..Sweet in the mouth; Micro-pungent; Cool in nature.GUIXIN; Liver; Stomach; Large intestine channel.To reduce phlegm the painful abdominal mass that disappears; Dissipating blood stasis; Pain relieving.Main chest and diaphragm is glutted; Gastral cavity abdomen painful abdominal mass is ached; Acid regurgitation regurgitation; Vomiting sputum; The head is giddy; Pained; Palpitation with a distress feeling; Rheumatalgia." the southern regions of the Yunnan Province book on Chinese herbal medicine ": warming the stomach, loose expectorant, softening the hard mass.Control cold-phlegm and stop stomach, vomiting is felt sick, acid regurgitation acid regurgitation.(taking passages " China's book on Chinese herbal medicine ")
Shore Flos Calystegiae sepii: another name Herba Ipomoeae Pes-Capraes, renal lobe sky sword.Convolvulaceae calystegia plant renal lobe DAWANHUA Calystegia soldanella (L.) R.Brown, is used as medicine with herb and root stock.Micro-hardship, temperature.Expelling wind and removing dampness, preventing phlegm from forming and stopping coughing.For cough, oedema due to nephritis, Fengshi Guanjie pain.(taking passages " national Chinese herbal medicine compilation ")
Mass Galla chinesis et camelliae Fermentata: the block made through fermentation with Folium Camelliae sinensis etc. for Galla Chinensis.Acid; Puckery; Micro-sweet; Flat.GUIXIN; Lung; Stomach warp.Moistening the lung and resolving phlegm; Hemostasis antidiarrheal; Antipyreticly to promote the production of body fluid.Main chronic cough due to asthenia of viscera; Pharyngalgia; Aphtha; Ulcerative gingivitis; Have blood in stool; Dysentery; Have loose bowels; Proctoptosis; Summer-heat is thirsty.(taking passages " China's book on Chinese herbal medicine ")
Shi Shi: call from Rangu, Limonitum, teacher's grass reality, dried shrimps, sand tribute.For sedge sand bores the fruit of sedge.Sweet in the mouth; Property is put down.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Stopping nausea and vomiting by lowering the adverse flow of QI.Main weakness of the spleen and stomach; Vomiting singultus." Haiyao Bencao, Oversea Materia Medica ": main tonify deficiency wins weary damage, warming intestines and stomach, and preventing or arresting vomiting is inverse, for a long time strong people of food.(taking passages " China's book on Chinese herbal medicine ")
Bai Ye does not turn over: another name Radix Gerberae Delavayi, large fire weed, Rhizoma Chiritae Eburneae fire weed, little Herba Ophioglossi, hoary hair.: be the root of feverfew hook bud Herba Leibnitziae.Acrid in the mouth; Micro-hardship; Property is put down.Removing heat-phlegm; Removing food stagnancy kills early.Main flu; Cough and asthma; Dysentery; Stomachache; Dyspepsia; Ascariasis; Traumatic hemorrhage.(taking passages " China's book on Chinese herbal medicine ")
Pericarpium Lagenariae sicerariae: another name gourd, bottle gourd, kettle, bottle gourd, a sweet a kind of edible gourd, Yao Zhou, a kind of edible gourd gourd, aunt Kui, bottle gourd, calabash.For the fruit of cucurbitaceous plant calabash, calabash courd.Sweet in the mouth; Light; Property is put down.Return lung; Spleen; Kidney channel.Diuretic; Detumescence; Logical woods; Eliminating stagnation.Main edema; Ascites; Jaundice; Quench one's thirst; Gonorrhea; Carbuncle." book on Chinese herbal medicine is new again ": diuretic.Control abdominal distention, jaundice.(taking passages " China's book on Chinese herbal medicine ")
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Caulis Euphorbiae Antiquori 5 ~ 10 weight portion, Folium desmoris 8 ~ 15 weight portion, ink-cap (Coprinus atramentartius) 10 ~ 30 weight portion, middle dominoes Herba pteridii latiusculi 20 ~ 30 weight portion, Radix Glycyrrhizae Preparata 20 ~ 35 weight portion, big legs Gaster caprae seu Ovis dish 15 ~ 25 weight portion, Fructus Akebiae 25 ~ 35 weight portion, Dasiphora fruticosa (L.) Rydb. 10 ~ 20 weight portion, flat bamboo surveys 25 ~ 40 weight portions, Radix Mimosae Pudicae 10 ~ 20 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15 ~ 30 weight portion, Habenaria aitchisonii 20 ~ 30 weight portion, Flos Musae 15 ~ 25 weight portion, shore Flos Calystegiae sepii 20 ~ 30 weight portion, Mass Galla chinesis et camelliae Fermentata 25 ~ 35 weight portion, real 20 ~ 30 weight portions of teacher, Bai Ye does not turn over 15 ~ 25 weight portions and Pericarpium Lagenariae sicerariae 25 ~ 35 weight portion.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be preferably: Caulis Euphorbiae Antiquori 5 ~ 8 weight portion, Folium desmoris 10 ~ 15 weight portion, ink-cap (Coprinus atramentartius) 20 ~ 25 weight portion, middle dominoes Herba pteridii latiusculi 20 ~ 25 weight portion, Radix Glycyrrhizae Preparata 20 ~ 30 weight portion, big legs Gaster caprae seu Ovis dish 15 ~ 20 weight portion, Fructus Akebiae 30 ~ 35 weight portion, Dasiphora fruticosa (L.) Rydb. 15 ~ 20 weight portion, flat bamboo surveys 30 ~ 40 weight portions, Radix Mimosae Pudicae 10 ~ 15 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20 ~ 25 weight portion, Habenaria aitchisonii 25 ~ 30 weight portion, Flos Musae 20 ~ 25 weight portion, shore Flos Calystegiae sepii 25 ~ 30 weight portion, Mass Galla chinesis et camelliae Fermentata 30 ~ 35 weight portion, real 25 ~ 30 weight portions of teacher, Bai Ye does not turn over 20 ~ 25 weight portions and Pericarpium Lagenariae sicerariae 30 ~ 35 weight portion.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably again: Caulis Euphorbiae Antiquori 6 weight portion, Folium desmoris 10 weight portion, ink-cap (Coprinus atramentartius) 25 weight portion, middle dominoes Herba pteridii latiusculi 22 weight portion, Radix Glycyrrhizae Preparata 30 weight portion, big legs Gaster caprae seu Ovis dish 20 weight portion, Fructus Akebiae 35 weight portion, Dasiphora fruticosa (L.) Rydb. 18 weight portion, flat bamboo surveys 35 weight portions, Radix Mimosae Pudicae 12 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 22 weight portion, Habenaria aitchisonii 28 weight portion, Flos Musae 20 weight portion, shore Flos Calystegiae sepii 28 weight portion, Mass Galla chinesis et camelliae Fermentata 33 weight portion, real 28 weight portions of teacher, Bai Ye does not turn over 22 weight portions and Pericarpium Lagenariae sicerariae 35 weight portion.
When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 85% ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 ~ 5 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 4 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.24 ~ 0.46:0.2 ~ 0.38, incapsulate in housing by described capsule 's content, obtain capsule finished product.
When the dosage form of described Chinese medicine preparation is oral liquid, its preparation method comprises the following steps:
The first step, by Caulis Euphorbiae Antiquori, Folium desmoris, ink-cap (Coprinus atramentartius), middle dominoes Herba pteridii latiusculi, Radix Glycyrrhizae Preparata, big legs Gaster caprae seu Ovis dish, Fructus Akebiae and Dasiphora fruticosa (L.) Rydb. mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 ~ 6 times of water gagings, soaks 5 ~ 10 hours, then boil 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28 ~ 1.30;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 25 ~ 35 hours, and refrigerated storage temperature is 2 ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: capsule prepared by the present invention
Caulis Euphorbiae Antiquori 60g, Folium desmoris 100g, ink-cap (Coprinus atramentartius) 250g, middle dominoes Herba pteridii latiusculi 220g, Radix Glycyrrhizae Preparata 300g, big legs Gaster caprae seu Ovis dish 200g, Fructus Akebiae 350g, Dasiphora fruticosa (L.) Rydb. 180g, the survey of flat bamboo 350g, Radix Mimosae Pudicae 120g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 220g, Habenaria aitchisonii 280g, Flos Musae 200g, shore Flos Calystegiae sepii 280g, Mass Galla chinesis et camelliae Fermentata 330g, teacher real 280g, Bai Ye do not turn over 220g and Pericarpium Lagenariae sicerariae 350g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 6 times is the ethanol of 90%, reflux 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 4 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 3 hours, pulverize, sieve, obtain 300 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.32:0.28, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Embodiment 2: oral solutions prepared by the present invention
Caulis Euphorbiae Antiquori 80g, Folium desmoris 120g, ink-cap (Coprinus atramentartius) 200g, middle dominoes Herba pteridii latiusculi 250g, Radix Glycyrrhizae Preparata 280g, big legs Gaster caprae seu Ovis dish 180g, Fructus Akebiae 330g, Dasiphora fruticosa (L.) Rydb. 160g, the survey of flat bamboo 400g, Radix Mimosae Pudicae 140g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 200g, Habenaria aitchisonii 300g, Flos Musae 250g, shore Flos Calystegiae sepii 250g, Mass Galla chinesis et camelliae Fermentata 350g, teacher real 250g, Bai Ye do not turn over 200g and Pericarpium Lagenariae sicerariae 330g.
Its preparation method comprises the following steps:
The first step, by Caulis Euphorbiae Antiquori, Folium desmoris, ink-cap (Coprinus atramentartius), middle dominoes Herba pteridii latiusculi, Radix Glycyrrhizae Preparata, big legs Gaster caprae seu Ovis dish, Fructus Akebiae and Dasiphora fruticosa (L.) Rydb. mixing, add relative to mixture 7 times amount determining alcohol be 85% alcohol reflux 4 times, each 2 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, soaks 8 hours, then boil 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.30;
3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 32 hours, and refrigerated storage temperature is 4 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.16; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002; The time of described heat treated is 35 minutes, and temperature is 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
Acute toxicity test
Oral solutions prepared by the capsule prepared with the embodiment of the present invention 1 and embodiment 2, capsule is dissolved in distilled water, gives 2 groups of white mice feeding dispensings or wiping respectively, observe 14 with 200 of clinical consumption per day times and 250 times; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.
Long term toxicity test
Capsule prepared by the embodiment of the present invention 1 to mice by 8.51, 18.97 and 38.56g crude drug/kg be dissolved in water, oral solutions prepared by the embodiment of the present invention 2 to mice by 9.08, 19.88 and 41.15g crude drug/kg, continuous uses 12 weeks are distinguished to 6 groups of mices, every day 2 times, and drug withdrawal is after 4 weeks, result shows: Chinese medicine of the present invention is to the hair of two groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: get the routine Simple Obesity Patient of this Out-patient Department 120, man 78 example, female 42 example, age 18-55 year, Body Mass Index (BMI) 28 ~ 45Kg/m
2.120 routine patients are divided into treatment group and matched group at random, treatment group 60 example, man 38 example, female 22 example, age 18-53 year, Body Mass Index (BMI) 28 ~ 42Kg/m
2; Matched group 60 example, man 40 example, female 20 example, age 19-55 year, Body Mass Index (BMI) 30 ~ 45Kg/m
2.Two groups of ages, sex and BMI etc., through statistical procedures, without significant difference, have comparability (P > 0.05)
Inclusion criteria: using Body Mass Index as diagnosis index, Body Mass Index (BMI)=body weight (kg)/(height (m))
2.Body Mass Index 26<BMI≤30 are Mild Obesity, and Body Mass Index 30<BMI≤40 are severe simple obesity, and Body Mass Index BMI>40 is severe simple obesity.
Exclusion standard: 1, Secondary Obesity patient; 2, severe cardiovascular disease patient; 3, Chronic Liver kidney diaseases medical history, alanine aminotransferase is greater than upper limits of normal 3 times, or creatinine is greater than 136 μm of ol/L; 4, cerebrovas-cularaccident or epileptic seizures is had; 5, anorexia nervosa or polyphagia patient; 6, the person that has Depression trend; 7, wet nurse, anemia of pregnant woman or have conceived purpose person;
Therapeutic Method: be divided into treatment phase and observation period.Treatment phase Therapeutic Method: the capsule of the treatment group oral embodiment of the present invention 1 ante cibum, every day 3 times, each 3,2 months courses for the treatment of.Sibutramine hydrochloride capsule 10mg is taken, every day 1 time during matched group breakfast every day.Two groups all stop drinking, stopping drinking sugary soda pop, stop strenuous exercise, the suitably amount of keeping on a diet.A body weight is respectively detected with centre before and after treatment.Normally whether treatments period observes spirit, sleep, symptom, defecation.Observation period: the time is treatment after date 6 months, and the object of observation is the effective and effective patient of treatments period, respectively detects a body weight before and after the observation period with centre, whether observe spirit, sleep, symptom, defecation normally simultaneously.
Treatment phase criterion of therapeutical effect: effective: Body Mass Index decline BMI >=4; Effective: Body Mass Index decline 2≤BMI<4 person; Invalid: Body Mass Index decline BMI<2 person.
The results are shown in Table 1:
Phase two groups of curative effect situations treated by table 1
| Group | n | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 60 | 46 | 11 | 3 | 57(95％) |
| Matched group | 60 | 19 | 24 | 17 | 43(71.7％) |
Treatments period, treatment group patient has no untoward reaction, in matched group patient, has 9 examples to occur xerostomia, there is anorexia and abdominal distention, epigastric discomfort in 5 examples, constipation appears in 3 examples, and insomnia appears in 2 examples, 2 examples occur that blood pressure raises and headache, but above-mentioned untoward reaction degree is comparatively light, and patient all can tolerate.
Observation period criterion of therapeutical effect: effective: body weight rises less than 2 kilograms persons; Effective: body weight rises 2-5 kilogram of person; Invalid: body weight is increased beyond 5 kilograms.
The results are shown in Table 2:
Table 2 observation period two groups of curative effect situations
| Group | n | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 57 | 51 | 5 | 1 | 56(98.2％) |
| Matched group | 43 | 11 | 17 | 15 | 28(65.1％) |
In sum, slimming medicine of the present invention, can help patient's quick weight-lossing in a short time, effective percentage high and fat-reducing after not easily rebound.
Model case: patient Zhao, man, 34 years old, height 181cm, body weight 124 kilograms.Do not like motion, having a meal feels like jelly from head to foot wants to lie down, and extremity are heavy, and trick is swollen, and especially thigh, buttocks and abdominal part, be diagnosed as Simple Obesity, uses the capsule of the embodiment 1 of Chinese medicine of the present invention, every day 3 times, each 3.Medication 30 days, waistline obviously reduces, and overall variation is very large, and continue medication to two month, weight loss to 85 kilogram, after medication, weight reducing is a lot, and the mental status is very good.6 months observation periods, body weight is increased to 85.6 kilograms.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat the Chinese medicine preparation of simple obesity for one kind, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Caulis Euphorbiae Antiquori, Folium desmoris, ink-cap (Coprinus atramentartius), middle dominoes Herba pteridii latiusculi, Radix Glycyrrhizae Preparata, big legs Gaster caprae seu Ovis dish, Fructus Akebiae, Dasiphora fruticosa (L.) Rydb., the survey of flat bamboo, Radix Mimosae Pudicae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Habenaria aitchisonii, Flos Musae, shore Flos Calystegiae sepii, Mass Galla chinesis et camelliae Fermentata, Shi Shi, Bai Ye do not turn over and Pericarpium Lagenariae sicerariae.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation is: Caulis Euphorbiae Antiquori 5 ~ 10 weight portion, Folium desmoris 8 ~ 15 weight portion, ink-cap (Coprinus atramentartius) 10 ~ 30 weight portion, middle dominoes Herba pteridii latiusculi 20 ~ 30 weight portion, Radix Glycyrrhizae Preparata 20 ~ 35 weight portion, big legs Gaster caprae seu Ovis dish 15 ~ 25 weight portion, Fructus Akebiae 25 ~ 35 weight portion, Dasiphora fruticosa (L.) Rydb. 10 ~ 20 weight portion, flat bamboo surveys 25 ~ 40 weight portions, Radix Mimosae Pudicae 10 ~ 20 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15 ~ 30 weight portion, Habenaria aitchisonii 20 ~ 30 weight portion, Flos Musae 15 ~ 25 weight portion, shore Flos Calystegiae sepii 20 ~ 30 weight portion, Mass Galla chinesis et camelliae Fermentata 25 ~ 35 weight portion, real 20 ~ 30 weight portions of teacher, Bai Ye does not turn over 15 ~ 25 weight portions and Pericarpium Lagenariae sicerariae 25 ~ 35 weight portion.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation is: Caulis Euphorbiae Antiquori 5 ~ 8 weight portion, Folium desmoris 10 ~ 15 weight portion, ink-cap (Coprinus atramentartius) 20 ~ 25 weight portion, middle dominoes Herba pteridii latiusculi 20 ~ 25 weight portion, Radix Glycyrrhizae Preparata 20 ~ 30 weight portion, big legs Gaster caprae seu Ovis dish 15 ~ 20 weight portion, Fructus Akebiae 30 ~ 35 weight portion, Dasiphora fruticosa (L.) Rydb. 15 ~ 20 weight portion, flat bamboo surveys 30 ~ 40 weight portions, Radix Mimosae Pudicae 10 ~ 15 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20 ~ 25 weight portion, Habenaria aitchisonii 25 ~ 30 weight portion, Flos Musae 20 ~ 25 weight portion, shore Flos Calystegiae sepii 25 ~ 30 weight portion, Mass Galla chinesis et camelliae Fermentata 30 ~ 35 weight portion, real 25 ~ 30 weight portions of teacher, Bai Ye does not turn over 20 ~ 25 weight portions and Pericarpium Lagenariae sicerariae 30 ~ 35 weight portion.
4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation is: Caulis Euphorbiae Antiquori 6 weight portion, Folium desmoris 10 weight portion, ink-cap (Coprinus atramentartius) 25 weight portion, middle dominoes Herba pteridii latiusculi 22 weight portion, Radix Glycyrrhizae Preparata 30 weight portion, big legs Gaster caprae seu Ovis dish 20 weight portion, Fructus Akebiae 35 weight portion, Dasiphora fruticosa (L.) Rydb. 18 weight portion, flat bamboo surveys 35 weight portions, Radix Mimosae Pudicae 12 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 22 weight portion, Habenaria aitchisonii 28 weight portion, Flos Musae 20 weight portion, shore Flos Calystegiae sepii 28 weight portion, Mass Galla chinesis et camelliae Fermentata 33 weight portion, real 28 weight portions of teacher, Bai Ye does not turn over 22 weight portions and Pericarpium Lagenariae sicerariae 35 weight portion.
5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 85% ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 ~ 5 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 4 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.24 ~ 0.46:0.2 ~ 0.38, incapsulate in housing by described capsule 's content, obtain capsule finished product.
6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is oral liquid, and its preparation method comprises the following steps:
The first step, by Caulis Euphorbiae Antiquori, Folium desmoris, ink-cap (Coprinus atramentartius), middle dominoes Herba pteridii latiusculi, Radix Glycyrrhizae Preparata, big legs Gaster caprae seu Ovis dish, Fructus Akebiae and Dasiphora fruticosa (L.) Rydb. mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 ~ 6 times of water gagings, soaks 5 ~ 10 hours, then boil 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28 ~ 1.30;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 25 ~ 35 hours, and refrigerated storage temperature is 2 ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
7. a preparation method for the Chinese medicine preparation as described in claim 1 to 6, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 85% ~ 95%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 ~ 5 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 4 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.24 ~ 0.46:0.2 ~ 0.38, incapsulate in housing by described capsule 's content, obtain capsule finished product.
8. the preparation method of the Chinese medicine preparation as described in claim 1 to 6, is characterized in that, the dosage form of described Chinese medicine preparation is oral liquid, and its preparation method comprises the following steps:
The first step, by Caulis Euphorbiae Antiquori, Folium desmoris, ink-cap (Coprinus atramentartius), middle dominoes Herba pteridii latiusculi, Radix Glycyrrhizae Preparata, big legs Gaster caprae seu Ovis dish, Fructus Akebiae and Dasiphora fruticosa (L.) Rydb. mixing, add relative to mixture 5 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 ~ 6 times of water gagings, soaks 5 ~ 10 hours, then boil 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28 ~ 1.30;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 25 ~ 35 hours, and refrigerated storage temperature is 2 ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.
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| CN201510103717.3A Pending CN104666783A (en) | 2015-03-09 | 2015-03-09 | Traditional Chinese medicine preparation for treating simple obesity and preparation method |
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| CN (1) | CN104666783A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114574A (en) * | 1994-07-07 | 1996-01-10 | 张喜全 | Fat-reducing powder and preparing method thereof |
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2015
- 2015-03-09 CN CN201510103717.3A patent/CN104666783A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1114574A (en) * | 1994-07-07 | 1996-01-10 | 张喜全 | Fat-reducing powder and preparing method thereof |
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Application publication date: 20150603 |